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3. [¹⁸F]MK-9470, a Positron Emission Tomography (PET) Tracer for in vivo Human PET Brain Imaging of the Cannabinoid-1 Receptor

Author

Burns, H. Donald, Van Laere, Koen, Sanabria-Bohórquez, Sandra, Hamill, Terence G., Bormans, Guy, Eng, Wai-si, Gibson, Ray, Ryan, Christine, Connolly, Brett, Patel, Shil, Krause, Stephen, Vanko, Amy, Van Hecken, Anne, Dupont, Patrick, De Lepeleire, Inge, Rothenberg, Paul, Stoch, S. Aubrey, Cote, Josee, Hagmann, William K., Jewell, James P., Lin, Linus S., Liu, Ping, Goulet, Mark T., Gottesdiener, Keith, Wagner, John A., de Hoon, Jan, Mortelmans, Luc, Fong, Tung M., and Hargreaves, Richard J.

Published
2007
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9. Case 3849 – Emplectonematidae Bürger, 1904 and Emplectonema Stimpson, 1857 (Nemertea, Monostilifera): proposed conservation of current usage by reversal of precedence of the family name with respect to Eunemertidae Joubin, 1894 and designation of a new type species for the genus

Author

Kajihara, Hiroshi, primary, Grygier, Mark J., additional, Andrade, Sónia C. S., additional, Bartolomaeus, Thomas, additional, Cherneva, Irina A., additional, Chernyshev, Alexei V., additional, von Döhren, Jörn, additional, Ellison, Christina I., additional, Gibson, Ray, additional, Giribet, Gonzalo, additional, Hiebert, Terra C., additional, Hookabe, Natsumi, additional, Junoy, Juan, additional, Kvist, Sebastian, additional, Maslakova, Svetlana A., additional, Mendes, Cecili B., additional, Norenburg, Jon L., additional, Polyakova, Neonila E., additional, Sagorny, Christina, additional, Schwartz, Megan L., additional, Strand, Malin, additional, Sun, Shichun, additional, Turbeville, James M., additional, and Zattara, Eduardo E., additional

Published
2021
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14. [[sup.18]F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor

Author

Burns, H. Donald, Van Laere, Koen, Sanabria-Bohorquez, Sandra, Hamill, Terence G., Bormans, Guy, Eng, Wai-si, Gibson, Ray, Ryan, Christine, Connolly, Brett, Patel, Shil, Krause, Stephen, Vanko, Amy, Van Hecken, Anne, Dupont, Patrick, De Lepeleire, Inge, Rothenberg, Paul, Stoch, S. Aubrey, Cote, Josee, Hagmann, William K., Jewell, James P., Lin, Linus S., Liu, Ping, Goulet, Mark T., Gottesdiener, Keith, Wagner, John A., de Hoon, Jan, Mortelmans, Luc, Fong, Tung M., and Hargreaves, Richard J.

Subjects
Cannabinoids -- Research, PET imaging -- Usage, Brain research, Science and technology
Abstract

[[sup.18]F]MK-9470 is a selective, high-affinity, inverse agonist (human I[C.sub.50], 0.7 nM) for the cannabinoid CB1 receptor (CB1R) that has been developed for use in human brain imaging. Autoradiographic studies in rhesus monkey brain showed that [[sup.18]F]MK-9470 binding is aligned with the reported distribution of CB1 receptors with high specific binding in the cerebral cortex, cerebellum, caudate/putamen, globus pallidus, substantia nigra, and hippocampus. Positron emission tomography (PET) imaging studies in rhesus monkeys showed high brain uptake and a distribution pattern generally consistent with that seen in the autoradiographic studies. Uptake was blocked by pretreatment with a potent CB1 inverse agonist, MK-0364. The ratio of total to nonspecific binding in putamen was 4-5:1, indicative of a strong specific signal that was confirmed to be reversible via displacement studies with MK-0364. Baseline PET imaging studies in human research subject demonstrated behavior of [[sup.18]F]MK-9470 very similar to that seen in monkeys, with very good test-retest variability (7%). Proof of concept studies in healthy young male human subjects showed that MK-0364, given orally, produced a dose-related reduction in [[sup.18]F]MK-9470 binding reflecting CBIR receptor occupancy by the drug. Thus, [[sup.18]F]MK-9470 has the potential to be a valuable, noninvasive research tool for the in vivo study of CB1R biology and pharmacology in a variety of neuropsychiatric disorders in humans. In addition, it allows demonstration of target engagement and noninvasive dose-occupancy studies to aid in dose selection for clinical trials of CB1R inverse agonists. inverse agonist occupancy

Published
2007

15. The European union’s 2010 target: Putting rare species in focus

Author

Fontaine, Benoît, Bouchet, Philippe, Van Achterberg, Kees, Alonso-Zarazaga, Miguel Angel, Araujo, Rafael, Asche, Manfred, Aspöck, Ulrike, Audisio, Paolo, Aukema, Berend, Bailly, Nicolas, Balsamo, Maria, Bank, Ruud A., Barnard, Peter, Belfiore, Carlo, Bogdanowicz, Wieslaw, Bongers, Tom, Boxshall, Geoffrey, Burckhardt, Daniel, Camicas, Jean-Louis, Chylarecki, Przemek, Crucitti, Pierangelo, Deharveng, Louis, Dubois, Alain, Enghoff, Henrik, Faubel, Anno, Fochetti, Romolo, Gargominy, Olivier, Gibson, David, Gibson, Ray, Gómez López, Maria Soledad, Goujet, Daniel, Harvey, Mark S., Heller, Klaus-Gerhard, Van Helsdingen, Peter, Hoch, Hannelore, De Jong, Herman, De Jong, Yde, Karsholt, Ole, Los, Wouter, Lundqvist, Lars, Magowski, Wojciech, Manconi, Renata, Martens, Jochen, Massard, Jos A., Massard-Geimer, Gaby, Mcinnes, Sandra J., Mendes, Luis F., Mey, Eberhard, Michelsen, Verner, Minelli, Alessandro, Nielsen, Claus, Nieto Nafría, Juan M., Van Nieukerken, Erik J., Noyes, John, Pape, Thomas, Pohl, Hans, De Prins, Willy, Ramos, Marian, Ricci, Claudia, Roselaar, Cees, Rota, Emilia, Schmidt-Rhaesa, Andreas, Segers, Hendrik, Strassen, Richard Zur, Szeptycki, Andrzej, Thibaud, Jean-Marc, Thomas, Alain, Timm, Tarmo, Van Tol, Jan, Vervoort, Wim, and Willmann, Rainer

Published
2007
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21. Energy saving ceramic metal halide lamps suitable for probe-start and pulse-start systems

Author

Steere, Tom, Gibson, Ray, and Tu, Junming

Subjects
Electric lamps -- Energy use -- Design and construction, Lamps -- Energy use -- Design and construction, Engineering design -- Methods, Energy efficiency -- Research, Engineering and manufacturing industries
Abstract

Reduction of energy consumption for lighting has received more and more attention as a global effort to preserve our natural resources. In past years, high efficiency pulse-start quartz metal halide (QMH) lamps have gained momentum and have been applied in many new installations. However, over 80 percent of systems installed in the North American (NA) market are probe-start ballasts. The technologically advanced ceramic discharge metal halide (CDM) lamp has emerged in the market having excellent color properties and improved lumen maintenance compared to QMH lamps while limited to operation on pulse-start metal halide ballasts. Furthermore, the existing QMH and CDM lamps are designed to operate at nominal power on these systems, therefore no energy savings can be realized in existing installations. In realizing the future, this paper describes new energy saving medium wattage CDM lamps that can directly retrofit on either probe-start or pulse-start ballasts. The lamps, which operate at 205 watts and 330 watts respectively on 250/400 watt ballasts, can save 18 percent in energy while providing the equivalent mean luminous flux, superior lumen maintenance, greater service life, and enhanced color properties compared to the existing QMH lamps. By utilizing the latest advancements in ceramic arc tube design, the energy saving CDM retrofit lamps can reliability start on probe-start ballasts. Furthermore, the lamps have universal orientation in openfixtures and long life. With significant energy savings and improved lamp features, the energy saving CDM lamps are ideal for existing and new lighting applications., 1 INTRODUCTION Energy conservation and preservation of natural resources are recognized as a top priority to protect the environment and global climate. Lighting consumes approximately 22 percent of the electrical [...]

Published
2010
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22. Evaluation of system energy savings of ceramic metal halide lamps suitable for probe-start and pulse-start systems

Author

Gibson, Ray and Steere, Tom

Subjects
Electric lamps -- Energy use, Lamps -- Energy use, Energy efficiency -- Analysis, Engineering and manufacturing industries
Abstract

Energy saving ceramic discharge metal halide lamps (CDM) have been developed to start and operate on magnetic probe and pulse start ballasts originally designed for quartz metal halide (QMH) lamps. The energy saving performance of these retrofit CDM lamps has been evaluated on several types of commercial magnetic ballast systems including constant wattage auto-transformers (CWA), reactors, and magnetic regulated lag (mag-reg) types. System evaluations result in linear models that depend on ballast type and lamp power. These models, which show excellent agreement with measurements, are used in Monte Carlo simulations to estimate the relative power savings that can be expected when replacing an installation of QMH lamps having a range of electrical characteristics, with the energy saving CDM retrofit lamps. The system evaluations show that the CDM lamps save 18 percent lamp power and an average system power savings of up to 17 percent., 1 INTRODUCTION High Intensity Discharge (HID) lamps have long been recognized as one of the most efficient light sources for a wide range of general lighting applications. While mercury vapor [...]

Published
2010
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29. A new genus and species of monostiliferous hoplonemertean colonizing an inchoate hydrothermal field on Juan de Fuca Ridge

Author

Rogers, Alex D., Gibson, Ray, and Tunnicliffe, Verena

Subjects
Worms -- Anatomy, Hydrothermal vents -- Natural history, Earth sciences
Abstract

A newly found genus and species of monostiliferous hoplonemertean, collected from a hydrothermal vent on the Juan de Fuca Ridge in the northeastern Pacific, is bright red in color and up to five centimeters long. Their type species is Thermanemertes valens. An important feature of the species is the presence of lipid-like globules related to a large numbers of mitochondria in the irregular groups of cells below the body wall musculature. These nemerteans are early colonizers of vents and vent endemic.

Published
1996

44. Nemertea

Author

Gibson, Ray, Bereiter-Hahn, Jürgen, editor, Matoltsy, A. Gedeon, editor, and Richards, K. Sylvia, editor

Published
1984
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45. Police powers to take body samples.

Author

Gibson, Ray

Subjects
Evidence (Law) -- Laws, regulations and rules, Criminal law -- Interpretation and construction, Body fluids -- Testimony, Victoria. Crimes (Amendment) Act 1997
Published
1998

46. The future of nemertean taxonomy (phylum Nemertea) — a proposal

Author

Sundberg, Per, Andrade, Sonia, Bartolomaeus, Thomas, Beckers, Patrick, von Döhren, Jörn, Krämer, Daria, Gibson, Ray, Giribet, Gonzalo, Herrera-Bachiller, Alfonso, Junoy, Juan, Kajihara, Hiroshi, Kvist, Sebastian, Kånneby, Tobias, Sun, Shi-Chun, Thiel, Martin, Turbeville, James, Strand, Malin, Sundberg, Per, Andrade, Sonia, Bartolomaeus, Thomas, Beckers, Patrick, von Döhren, Jörn, Krämer, Daria, Gibson, Ray, Giribet, Gonzalo, Herrera-Bachiller, Alfonso, Junoy, Juan, Kajihara, Hiroshi, Kvist, Sebastian, Kånneby, Tobias, Sun, Shi-Chun, Thiel, Martin, Turbeville, James, and Strand, Malin

Published
2016
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47. The future of nemertean taxonomy (phylum Nemertea) - a proposal

Author

Sundberg, Per, primary, Andrade, Sónia C. S., additional, Bartolomaeus, Thomas, additional, Beckers, Patrick, additional, von Döhren, Jörn, additional, Krämer, Daria, additional, Gibson, Ray, additional, Giribet, Gonzalo, additional, Herrera-Bachiller, Alfonso, additional, Junoy, Juan, additional, Kajihara, Hiroshi, additional, Kvist, Sebastian, additional, Kånneby, Tobias, additional, Sun, Shi-Chun, additional, Thiel, Martin, additional, Turbeville, James M., additional, and Strand, Malin, additional

Published
2016
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49. The European union’s 2010 target: Putting rare species in focus

Author

Fontaine, Benoît, Zoologia, Fontaine, Benoît, Bouchet, Philippe, Van Achterberg, Kees, Alonso Zarazaga, M. A., Araujo, Rafael, Asche, Manfred, Aspöck, Ulrike, Audisio, Paolo, Aukema, Berend, Bailly, Nicolas, Balsamo, María, Bank, Ruud, Barnard, Peter, Belfiore, Carlo, Bongers, Tom, Boxshall, Geoffrey, Burckhardt, Daniel, Camicas, Jean-Louis, Chylarecki, Przemek, Crucitti, Pierangelo, Deharveng, Lousi, Dubois, Alain, Enghoff, Henrik, Faubel, Anno, Fochetti, Romolo, Gargominy, Olivier, Gibson, David, Gibson, Ray, Gómez López, María Soledad, Goujet, Daniel, Harvey, Mark, Heller, Klaus Gerhard, Van Helsdingen, Peter, Hoch, Hannelore, De Jong, Herman, De Jong, Yde, Karsholt, Ole, Los, Wouter, Lundquist, Lars, Magowski, Wojciech, Manconi, Renata, Martens, Jochen, Massard, Jos A., Massard Geimer, Gaby, Mcinnes, Sandra J., Mendes, Luis F., Mey, Eberhard, Michelsen, Verner, Minelli, Alessandro, Nielsen, Claus, Nieto Nafría, Juan M., Van Nieukerken, Erik J., Noyes, John, Pape, Thomas, Pohl, Hans, De Prins, Willy, Ramos, Marian, Ricci, Claudia, Roselaar, Cees, Rota, Emilia, Schmidt Rhaesa, Andreas, Segers, Hendrik, Zur Strassen, Richard, Szeptycki, Andrzej, Thibaud, Jean Marc, Thomas, Alain, Timm, Tarmo, Van Tol, Jan, Vervoort, Wim, Willmann, Rainer, Bogdanowicz, Wieslaw, Fontaine, Benoît, Zoologia, Fontaine, Benoît, Bouchet, Philippe, Van Achterberg, Kees, Alonso Zarazaga, M. A., Araujo, Rafael, Asche, Manfred, Aspöck, Ulrike, Audisio, Paolo, Aukema, Berend, Bailly, Nicolas, Balsamo, María, Bank, Ruud, Barnard, Peter, Belfiore, Carlo, Bongers, Tom, Boxshall, Geoffrey, Burckhardt, Daniel, Camicas, Jean-Louis, Chylarecki, Przemek, Crucitti, Pierangelo, Deharveng, Lousi, Dubois, Alain, Enghoff, Henrik, Faubel, Anno, Fochetti, Romolo, Gargominy, Olivier, Gibson, David, Gibson, Ray, Gómez López, María Soledad, Goujet, Daniel, Harvey, Mark, Heller, Klaus Gerhard, Van Helsdingen, Peter, Hoch, Hannelore, De Jong, Herman, De Jong, Yde, Karsholt, Ole, Los, Wouter, Lundquist, Lars, Magowski, Wojciech, Manconi, Renata, Martens, Jochen, Massard, Jos A., Massard Geimer, Gaby, Mcinnes, Sandra J., Mendes, Luis F., Mey, Eberhard, Michelsen, Verner, Minelli, Alessandro, Nielsen, Claus, Nieto Nafría, Juan M., Van Nieukerken, Erik J., Noyes, John, Pape, Thomas, Pohl, Hans, De Prins, Willy, Ramos, Marian, Ricci, Claudia, Roselaar, Cees, Rota, Emilia, Schmidt Rhaesa, Andreas, Segers, Hendrik, Zur Strassen, Richard, Szeptycki, Andrzej, Thibaud, Jean Marc, Thomas, Alain, Timm, Tarmo, Van Tol, Jan, Vervoort, Wim, Willmann, Rainer, and Bogdanowicz, Wieslaw

Abstract

The European Union has adopted the ambitious target of halting the loss of biodiversity by 2010. Several indicators have been proposed to assess progress towards the 2010 target, two of them addressing directly the issue of species decline. In Europe, the Fauna Europaea database gives an insight into the patterns of distribution of a total dataset of 130,000 terrestrial and freshwater species without taxonomic bias, and provide a unique opportunity to assess the feasibility of the 2010 target. It shows that the vast majority of European species are rare, in the sense that they have a restricted range. Considering this, the paper discusses whether the 2010 target indicators really cover the species most at risk of extinction. The analysis of a list of 62 globally extinct European taxa shows that most contemporary extinctions have affected narrow-range taxa or taxa with strict ecological requirements. Indeed, most European species listed as threatened in the IUCN Red List are narrow-range species. Conversely, there are as many wide-range species as narrow-range endemics in the list of protected species in Europe (Bird and Habitat Directives). The subset of biodiversity captured by the 2010 target indicators should be representative of the whole biodiversity in terms of patterns of distribution and abundance. Indicators should not overlook a core characteristic of biodiversity, i.e. the large number of narrow-range species and their intrinsic vulnerability. With ill-selected indicator species, the extinction of narrowrange endemics would go unnoticed

Published
2015

50. The European union’s 2010 target: Putting rare species in focus

Author

Zoologia, Fontaine, Benoît, Bouchet, Philippe, Van Achterberg, Kees, Alonso Zarazaga, M. A., Araujo, Rafael, Asche, Manfred, Aspöck, Ulrike, Audisio, Paolo, Aukema, Berend, Bailly, Nicolas, Balsamo, María, Bank, Ruud, Barnard, Peter, Belfiore, Carlo, Bongers, Tom, Boxshall, Geoffrey, Burckhardt, Daniel, Camicas, Jean-Louis, Chylarecki, Przemek, Crucitti, Pierangelo, Deharveng, Lousi, Dubois, Alain, Enghoff, Henrik, Faubel, Anno, Fochetti, Romolo, Gargominy, Olivier, Gibson, David, Gibson, Ray, Gómez López, María Soledad, Goujet, Daniel, Harvey, Mark, Heller, Klaus Gerhard, Van Helsdingen, Peter, Hoch, Hannelore, De Jong, Herman, De Jong, Yde, Karsholt, Ole, Los, Wouter, Lundquist, Lars, Magowski, Wojciech, Manconi, Renata, Martens, Jochen, Massard, Jos A., Massard Geimer, Gaby, Mcinnes, Sandra J., Mendes, Luis F., Mey, Eberhard, Michelsen, Verner, Minelli, Alessandro, Nielsen, Claus, Nieto Nafría, Juan M., Van Nieukerken, Erik J., Noyes, John, Pape, Thomas, Pohl, Hans, De Prins, Willy, Ramos, Marian, Ricci, Claudia, Roselaar, Cees, Rota, Emilia, Schmidt Rhaesa, Andreas, Segers, Hendrik, Zur Strassen, Richard, Szeptycki, Andrzej, Thibaud, Jean Marc, Thomas, Alain, Timm, Tarmo, Van Tol, Jan, Vervoort, Wim, Willmann, Rainer, Bogdanowicz, Wieslaw, Zoologia, Fontaine, Benoît, Bouchet, Philippe, Van Achterberg, Kees, Alonso Zarazaga, M. A., Araujo, Rafael, Asche, Manfred, Aspöck, Ulrike, Audisio, Paolo, Aukema, Berend, Bailly, Nicolas, Balsamo, María, Bank, Ruud, Barnard, Peter, Belfiore, Carlo, Bongers, Tom, Boxshall, Geoffrey, Burckhardt, Daniel, Camicas, Jean-Louis, Chylarecki, Przemek, Crucitti, Pierangelo, Deharveng, Lousi, Dubois, Alain, Enghoff, Henrik, Faubel, Anno, Fochetti, Romolo, Gargominy, Olivier, Gibson, David, Gibson, Ray, Gómez López, María Soledad, Goujet, Daniel, Harvey, Mark, Heller, Klaus Gerhard, Van Helsdingen, Peter, Hoch, Hannelore, De Jong, Herman, De Jong, Yde, Karsholt, Ole, Los, Wouter, Lundquist, Lars, Magowski, Wojciech, Manconi, Renata, Martens, Jochen, Massard, Jos A., Massard Geimer, Gaby, Mcinnes, Sandra J., Mendes, Luis F., Mey, Eberhard, Michelsen, Verner, Minelli, Alessandro, Nielsen, Claus, Nieto Nafría, Juan M., Van Nieukerken, Erik J., Noyes, John, Pape, Thomas, Pohl, Hans, De Prins, Willy, Ramos, Marian, Ricci, Claudia, Roselaar, Cees, Rota, Emilia, Schmidt Rhaesa, Andreas, Segers, Hendrik, Zur Strassen, Richard, Szeptycki, Andrzej, Thibaud, Jean Marc, Thomas, Alain, Timm, Tarmo, Van Tol, Jan, Vervoort, Wim, Willmann, Rainer, and Bogdanowicz, Wieslaw

Abstract

The European Union has adopted the ambitious target of halting the loss of biodiversity by 2010. Several indicators have been proposed to assess progress towards the 2010 target, two of them addressing directly the issue of species decline. In Europe, the Fauna Europaea database gives an insight into the patterns of distribution of a total dataset of 130,000 terrestrial and freshwater species without taxonomic bias, and provide a unique opportunity to assess the feasibility of the 2010 target. It shows that the vast majority of European species are rare, in the sense that they have a restricted range. Considering this, the paper discusses whether the 2010 target indicators really cover the species most at risk of extinction. The analysis of a list of 62 globally extinct European taxa shows that most contemporary extinctions have affected narrow-range taxa or taxa with strict ecological requirements. Indeed, most European species listed as threatened in the IUCN Red List are narrow-range species. Conversely, there are as many wide-range species as narrow-range endemics in the list of protected species in Europe (Bird and Habitat Directives). The subset of biodiversity captured by the 2010 target indicators should be representative of the whole biodiversity in terms of patterns of distribution and abundance. Indicators should not overlook a core characteristic of biodiversity, i.e. the large number of narrow-range species and their intrinsic vulnerability. With ill-selected indicator species, the extinction of narrowrange endemics would go unnoticed

Published
2015

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