11 results on '"Giannotti, Rocco"'
Search Results
2. We are What We Eat: Impact of Food from Short Supply Chain on Metabolic Syndrome
- Author
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Santulli, Gaetano, primary, Pascale, Valeria, additional, Finelli, Rosa, additional, Visco, Valeria, additional, Giannotti, Rocco, additional, Massari, Angelo, additional, Morisco, Carmine, additional, Ciccarelli, Michele, additional, Illario, Maddalena, additional, Iaccarino, Guido, additional, and Coscioni, Enrico, additional
- Published
- 2019
- Full Text
- View/download PDF
3. Larger blood pressure reduction by fixed-dose compared to free dose combination therapy of ace inhibitor and calcium antagonist in hypertensive patients
- Author
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Visco, Valeria, Finelli, Rosa, Pascale, Antonietta Valeria, Giannotti, Rocco, Fabbricatore, Davide, Ragosa, Nicola, Ciccarelli, Michele, and Iaccarino, Guido
- Subjects
ACE Inhibitors ,Blood pressure control ,Hypertension ,Combination therapy ,Calcium antagonist - Abstract
The introduction of fixed combination of ACEi+CCB (Fixed) has significantly increased patients compliance and adherence to therapy. At the moment, however, there are no data suggesting the better control of once-daily fixed (Fixed) over free doses in separate administrations combination therapy in hypertensives. In a population of 39 consecutive outpatient patients referred to the departmental Hypertension clinic of the University Hospital of Salerno Medical School with the first diagnosis of arterial hypertension, we tested the hypothesis that the Fixed achieve a better control of blood pressure than the Free combination. Patients were randomized to either strategy and after 3 months patients underwent a clinical assessment to evaluate the antihypertensive effect. The two groups, matched for anthropometric and clinical parameters, received Amlodipine (5-10 mg/daily) and Perindopril (5-10 mg/daily). Perindopril and Amlodipine doses did not significantly differ between the two groups. After 3 months BP control was improved in both groups and BP targets were similarly reached in both groups (SBP; Fixed: 61.54%; Free 69.23%; n.s. DPB; Fixed: 80.77%; Free 84.62%; n.s.). The reduction in systolic blood pressure was similar in both groups (Fixed:7.64±2.49%; Free: 7.81±4.00%, n.s.), while the reduction of diastolic blood pressure was greater in the Fixed group (Fixed: 14.22±2.03%; Free: 4.92±5.00%, p
- Published
- 2017
- Full Text
- View/download PDF
4. Cardiac eccentric remodeling in patients with rheumatoid arthritis
- Author
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Pascale, Valeria, primary, Finelli, Rosa, additional, Giannotti, Rocco, additional, Coscioni, Enrico, additional, Izzo, Raffaele, additional, Rozza, Francesco, additional, Caputo, Dario, additional, Moscato, Paolo, additional, Iaccarino, Guido, additional, and Ciccarelli, Michele, additional
- Published
- 2018
- Full Text
- View/download PDF
5. Abstract P197: Vitamin D, Paratohormone and Cardiovascular Risk: The Good, the Bad and the Ugly
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Giannotti, Rocco, primary, Pascale, Valeria, additional, Finelli, Rosa, additional, Visco, Valeria, additional, Matula, Ida, additional, Ragosa, Nicola, additional, massari, Angelo, additional, Di Sevo, Maria G, additional, Ciccarelli, Michele, additional, and Iaccarino, Guido, additional
- Published
- 2017
- Full Text
- View/download PDF
6. Abstract P124: “Beyond Silos” Model of Homecare Improves Blood Pressure Control in Multimorbid Hypertensive Patients
- Author
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Pascale, Antonietta Valeria, primary, Finelli, Rosa, additional, Giannotti, Rocco, additional, Visco, Valeria, additional, Matula, Ida, additional, Vairo, Giuseppe, additional, Ciccarelli, Michele, additional, Coscioni, Enrico, additional, and Iaccarino, Guido, additional
- Published
- 2016
- Full Text
- View/download PDF
7. Abstract 16382: Length of Food Chain is Crucial in Determining the Impact of Mediterranean Diet on Metabolic Syndrome and Cardiovascular Risk
- Author
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Santulli, Gaetano, Pascale, Valeria, Finelli, Rosa, Visco, Valeria, Coscioni, Enrico, Giannotti, Rocco, Massari, Angelo, Ciccarelli, Michele, and Iaccarino, Guido
- Abstract
Introduction:Substantial evidence has shown that Mediterranean diet can reduce the risk of metabolic syndrome (MS). However, the development of retail distribution has radically changed food supply worldwide. For instance, in the Mediterranean area, industrial retail favors shipments of groceries from regions that are intensive producers of mass food, generating the long supply chain (LSC) of food; on the other hand, short supply chains (SSCs) typically involve local self-producers promoting local markets. To our knowledge, the role of food retail and distribution in the determination of the risk of developing MS has not been studied hitherto.Hypothesis:We hypothesized that food chain length could affect the risk of developing metabolic alterations such as MS in a population accustomed to Mediterranean diet.Methods:We compared the SSC of food, in which aliments are mainly produced in loco, usually with traditional and low-technology methodologies, to the LSC of food. MS was defined using the latest ?Harmonized Criteria? to diagnose MS [CirculationVol.120 (16), Pg.1640]. The study was registered in the ClincalTrial.govdatabase (NCT03305276).Results:We recruited 407 subjects (average age: 56 years; 59% males), all adhering to Mediterranean diet, living in rural or urbanized areas of Southern Italy. The most important source of food in rural areas is represented by locally grown vegetables and meat of courtyard animals (SSC), whereas in metropolitan areas people mainly eat retail food (LSC). The actual dietary habits were confirmed through a validate questionnaire, designed to distinguish SSC and LSC viaa specific score. No significant differences were observed between SSC and LSC groups in terms of common demographic and metabolic parameters. Intriguingly, we found that being on Mediterranean diet with a SSC significantly (p=0.007) reduced the prevalence of MS compared with LSC, a result that was confirmed after correcting for confounding variables.Conclusions:Taken together, our findings show for the first time that the length of food supply chain is an independent predictor of the risk of MS in a population accustomed to Mediterranean diet, supporting the importance of local food environments in the determination of cardiovascular risk.
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- 2019
- Full Text
- View/download PDF
8. We are What We Eat: Impact of Food from Short Supply Chain on Metabolic Syndrome
- Author
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Rocco Giannotti, Gaetano Santulli, Michele Ciccarelli, Enrico Coscioni, Rosa Finelli, Carmine Morisco, Valeria Visco, Guido Iaccarino, Angelo Massari, Maddalena Illario, Valeria Pascale, Santulli, Gaetano, Pascale, Valeria, Finelli, Rosa, Visco, Valeria, Giannotti, Rocco, Massari, Angelo, Morisco, Carmine, Ciccarelli, Michele, Illario, Maddalena, Iaccarino, Guido, and Coscioni, Enrico
- Subjects
cardiovascular risk ,Mediterranean diet ,Supply chain ,Population ,Retail distribution ,Distribution (economics) ,mediterranean diet ,supply chain of food ,metabolic syndrome ,food retail ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,Food chain ,0302 clinical medicine ,Food supply ,Environmental health ,Medicine ,030212 general & internal medicine ,education ,2. Zero hunger ,education.field_of_study ,business.industry ,General Medicine ,medicine.disease ,Metabolic syndrome ,business - Abstract
Food supply in the Mediterranean area has been recently modified by big retail distribution; for instance, industrial retail has favored shipments of groceries from regions that are intensive producers of mass food, generating a long supply chain (LSC) of food that opposes short supply chains (SSCs) that promote local food markets. However, the actual functional role of food retail and distribution in the determination of the risk of developing metabolic syndrome (MetS) has not been studied hitherto. The main aim of this study was to test the effects of food chain length on the prevalence of MetS in a population accustomed to the Mediterranean diet. We conducted an observational study in Southern Italy on individuals adhering to the Mediterranean diet. We examined a total of 407 subjects (41% females) with an average age of 56 ± 14.5 years (as standard deviation) and found that being on the Mediterranean diet with a SSC significantly reduces the prevalence of MetS compared with the LSC (SSC: 19.65%, LSC: 31.46%; p: 0.007). Our data indicate for the first time that the length of food supply chain plays a key role in determining the risk of MetS in a population adhering to the Mediterranean diet.
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- 2019
9. Vitamin D, parathyroid hormone and cardiovascular risk: The good, the bad and the ugly
- Author
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Raffaele Izzo, Rosa Finelli, Guido Iaccarino, Enrico Coscioni, Ida Matula, Antonietta Valeria Pascale, Nicola Ragosa, Bruno Trimarco, Pietro Mazzeo, Michele Ciccarelli, Maddalena Illario, Angelo Massari, Valeria Visco, Davide Fabbricatore, Rocco Giannotti, Pascale, Antonietta V., Finelli, Rosa, Giannotti, Rocco, Visco, Valeria, Fabbricatore, Davide, Matula, Ida, Mazzeo, Pietro, Ragosa, Nicola, Massari, Angelo, Izzo, Raffaele, Coscioni, Enrico, Illario, Maddalena, Ciccarelli, Michele, Trimarco, Bruno, and Iaccarino, Guido
- Subjects
Male ,Percentile ,25-hydroxyvitamin D cholecalciferol ,aging ,blood pressure ,cardiovascular events ,cardiovascular risk ,Cardiology and Cardiovascular Medicine ,Parathyroid hormone ,030204 cardiovascular system & hematology ,0302 clinical medicine ,Risk Factors ,030212 general & internal medicine ,Young adult ,Vitamin D ,Research Articles ,Aged, 80 and over ,education.field_of_study ,Framingham Risk Score ,Age Factors ,General Medicine ,Middle Aged ,cardiovascular event ,Italy ,Cardiovascular Diseases ,Parathyroid Hormone ,Female ,Adult ,medicine.medical_specialty ,Adolescent ,Population ,Risk Assessment ,03 medical and health sciences ,Young Adult ,Sex Factors ,Internal medicine ,medicine ,Vitamin D and neurology ,Humans ,education ,Aged ,Population mean ,business.industry ,Vitamin D Deficiency ,Endocrinology ,Blood pressure ,Multivariate Analysis ,Linear Models ,business - Abstract
25-Hydroxyvitamin D insufficiency and increased cardiovascular risk (CVR) association is still debated. The vitamin D (VitD)-dependent parathyroid hormone (PTH) is considered as the possible actuator of VitD effects on CVR. To investigate the association of CVR, PTH and VitD, we carried out blood pressure measurements and blood samples and collected information on dietary habits, anamnestic, clinical and metabolic data of 451 participants in the Salerno area (Southern Italy) during the World Hypertension Day (17 May). CVR was calculated according to the Framingham CVR charts. The overall population mean age was 51.6 ± 0.7 years, and female sex was slightly prevalent (55%). VitD deficiency (
- Published
- 2018
10. Cardiac eccentric remodeling in patients with rheumatoid arthritis
- Author
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Guido Iaccarino, Paolo Moscato, Francesco Rozza, Michele Ciccarelli, Valeria Pascale, Raffaele Izzo, Rosa Finelli, Dario Caputo, Enrico Coscioni, Rocco Giannotti, Pascale, Valeria, Finelli, Rosa, Giannotti, Rocco, Coscioni, Enrico, Izzo, Raffaele, Rozza, Francesco, Caputo, Dario, Moscato, Paolo, Iaccarino, Guido, and Ciccarelli, Michele
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Heart Ventricles ,Population ,lcsh:Medicine ,Arthritis ,030204 cardiovascular system & hematology ,Article ,Anti-Citrullinated Protein Antibodies ,Sudden cardiac death ,Arthritis, Rheumatoid ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Humans ,Eccentric ,lcsh:Science ,Ventricular remodeling ,education ,Aged ,030203 arthritis & rheumatology ,education.field_of_study ,Multidisciplinary ,Ventricular Remodeling ,business.industry ,lcsh:R ,Heart ,Gamma globulin ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Ventricle ,Rheumatoid arthritis ,Cardiology ,Female ,lcsh:Q ,gamma-Globulins ,business - Abstract
It is known that patients with rheumatoid arthritis (RA) have a higher risk of coronary heart disease and sudden cardiac death. Abnormalities in cardiac geometry appear to be involved in the setting of the cardiovascular risk, but it has never been specifically investigated in RA. We enrolled 44 patients with RA compared to 131 subjects without RA (normal, N): The RA aged between 18 and 70 years (mean 48.3 ± 2.1), 25 females, BMI 27.6 ± 0.9; N, of equal age (48.6 ± 1.2, n.s.), included 80 females (BMI 26.7 ± 0.2, ns). Cardiac Ultrasounds showed an increase of the diameter of the left ventricle but not in the septum with reduction of relative wall thickness (RWT) in the RA population compared to N. Relative wall thickness inversely correlates with biochemical parameters of inflammatory response (gamma globulin, p
- Published
- 2018
11. Larger Blood Pressure Reduction by Fixed-Dose Compared to Free Dose Combination Therapy of ACE Inhibitor and Calcium Antagonist in Hypertensive Patients.
- Author
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Visco V, Finelli R, Pascale AV, Giannotti R, Fabbricatore D, Ragosa N, Ciccarelli M, and Iaccarino G
- Abstract
The introduction of fixed combination of ACEi+CCB (Fixed) has significantly increased patients compliance and adherence to therapy. At the moment, however, there are no data suggesting the better control of once-daily fixed (Fixed) over free doses in separate administrations combination therapy in hypertensives. In a population of 39 consecutive outpatient patients referred to the departmental Hypertension clinic of the University Hospital of Salerno Medical School with the first diagnosis of arterial hypertension, we tested the hypothesis that the Fixed achieve a better control of blood pressure than the Free combination. Patients were randomized to either strategy and after 3 months patients underwent a clinical assessment to evaluate the antihypertensive effect. The two groups, matched for anthropometric and clinical parameters, received Amlodipine (5-10 mg/daily) and Perindopril (5-10 mg/daily). Perindopril and Amlodipine doses did not significantly differ between the two groups. After 3 months BP control was improved in both groups and BP targets were similarly reached in both groups (SBP; Fixed: 61.54%; Free 69.23%; n.s. DPB; Fixed: 80.77%; Free 84.62%; n.s.). The reduction in systolic blood pressure was similar in both groups (Fixed:7.64±2.49%; Free: 7.81±4.00%, n.s.), while the reduction of diastolic blood pressure was greater in the Fixed group (Fixed: 14.22±2.03%; Free: 4.92±5.00%, p<0.05). Although both strategies are effective in reducing BP, the use of Fixed dose has an advantage in the reduction of BP. The present study does not allow to identify the mechanisms of this difference, which can be assumed to be due to the pharmacokinetics of the drugs administered in once-daily fixed combination.
- Published
- 2017
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