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412 results on '"Giannetti, Nadia"'

3. Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction: a pre-specified analysis of EMPEROR-Preserved

Author

Anker, Stefan D., Butler, Javed, Usman, Muhammad Shariq, Filippatos, Gerasimos, Ferreira, João Pedro, Bocchi, Edimar, Böhm, Michael, Rocca, Hans Pieter Brunner-La, Choi, Dong-Ju, Chopra, Vijay, Chuquiure, Eduardo, Giannetti, Nadia, Gomez-Mesa, Juan Esteban, Janssens, Stefan, Januzzi, James L., González-Juanatey, José R., Merkely, Bela, Nicholls, Stephen J., Perrone, Sergio V., Piña, Ileana L., Ponikowski, Piotr, Senni, Michele, Sim, David, Spinar, Jindrich, Squire, Iain, Taddei, Stefano, Tsutsui, Hiroyuki, Verma, Subodh, Vinereanu, Dragos, Zhang, Jian, Iwata, Tomoko, Schnee, Janet M., Brueckmann, Martina, Pocock, Stuart J., and Zannad, Faiez

Published
2022
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4. A randomized controlled trial of renin-angiotensin-aldosterone system inhibitor management in patients admitted in hospital with COVID-19

Author

Sharma, Abhinav, Elharram, Malik, Afilalo, Jonathan, Flannery, Alexandria, Afilalo, Marc, Tselios, Chris, Ni, Jiayi, Ezekowitz, Justin A., Cheng, Matthew P., Ambrosy, Andrew P., Zannad, Faiez, Brophy, James M., Giannetti, Nadia, Bessissow, Amal, Kronfli, Nadine, Marelli, Ariane, Aziz, Haya, Alqahtani, Mohammad, Aflaki, Mona, Craig, Morgan, Lopes, Renato D., and Ferreira, João Pedro

Published
2022
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5. Evaluating the Reparative Potential of Secretome from Patient-Derived Induced Pluripotent Stem Cells during Ischemia–Reperfusion Injury in Human Cardiomyocytes.

Author

Rody, Elise, Zwaig, Jeremy, Derish, Ida, Khan, Kashif, Kachurina, Nadezda, Gendron, Natalie, Giannetti, Nadia, Schwertani, Adel, and Cecere, Renzo

Subjects
INDUCED pluripotent stem cells, PLURIPOTENT stem cells, SERUM-free culture media, INTRACELLULAR calcium, STEM cells
Abstract

During a heart attack, ischemia causes losses of billions of cells; this is especially concerning given the minimal regenerative capability of cardiomyocytes (CMs). Heart remuscularization utilizing stem cells has improved cardiac outcomes despite little cell engraftment, thereby shifting focus to cell-free therapies. Consequently, we chose induced pluripotent stem cells (iPSCs) given their pluripotent nature, efficacy in previous studies, and easy obtainability from minimally invasive techniques. Nonetheless, using iPSC secretome-based therapies for treating injured CMs in a clinical setting is ill-understood. We hypothesized that the iPSC secretome, regardless of donor health, would improve cardiovascular outcomes in the CM model of ischemia–reperfusion (IR) injury. Episomal-generated iPSCs from healthy and dilated cardiomyopathy (DCM) donors, passaged 6–10 times, underwent 24 h incubation in serum-free media. Protein content of the secretome was analyzed by mass spectroscopy and used to treat AC16 immortalized CMs during 5 h reperfusion following 24 h of hypoxia. IPSC-derived secretome content, independent of donor health status, had elevated expression of proteins involved in cell survival pathways. In IR conditions, iPSC-derived secretome increased cell survival as measured by metabolic activity (p < 0.05), cell viability (p < 0.001), and maladaptive cellular remodelling (p = 0.052). Healthy donor-derived secretome contained increased expression of proteins related to calcium contractility compared to DCM donors. Congruently, only healthy donor-derived secretomes improved CM intracellular calcium concentrations (p < 0.01). Heretofore, secretome studies mainly investigated differences relating to cell type rather than donor health. Our work suggests that healthy donors provide more efficacious iPSC-derived secretome compared to DCM donors in the context of IR injury in human CMs. These findings illustrate that the regenerative potential of the iPSC secretome varies due to donor-specific differences. [ABSTRACT FROM AUTHOR]

Published
2024
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7. CCS/CHFS Heart Failure Guidelines Update: Defining a New Pharmacologic Standard of Care for Heart Failure With Reduced Ejection Fraction

Author

McDonald, Michael, Virani, Sean, Chan, Michael, Ducharme, Anique, Ezekowitz, Justin A., Giannetti, Nadia, Heckman, George A., Howlett, Jonathan G., Koshman, Sheri L., Lepage, Serge, Mielniczuk, Lisa, Moe, Gordon W., O’Meara, Eileen, Swiggum, Elizabeth, Toma, Mustafa, Zieroth, Shelley, Anderson, Kim, Bray, Sharon A., Clarke, Brian, Cohen-Solal, Alain, D’Astous, Michel, Davis, Margot, De, Sabe, Grant, Andrew D.M., Grzeslo, Adam, Heshka, Jodi, Keen, Sabina, Kouz, Simon, Lee, Douglas, Masoudi, Frederick A., McKelvie, Robert, Parent, Marie-Claude, Poon, Stephanie, Rajda, Miroslaw, Sharma, Abhinav, Siatecki, Kyla, Storm, Kate, Sussex, Bruce, Van Spall, Harriette, and Yip, Amelia Ming Ching

Published
2021
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8. Progression of Tricuspid Regurgitation After Surgery for Ischemic Mitral Regurgitation

Author

Miller, Marissa A., Taddei-Peters, Wendy C., Buxton, Dennis, Caulder, Ron, Geller, Nancy L., Gordon, David, Jeffries, Neal O., Lee, Albert, Moy, Claudia S., Gombos, Ilana Kogan, Ralph, Jennifer, Weisel, Richard D., Gardner, Timothy J., O’Gara, Patrick T., Rose, Eric A., Gelijns, Annetine C., Parides, Michael K., Ascheim, Deborah D., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, Chang, Helena, Chase, Melissa, Foo, James, Chen, Yingchun, Goldfarb, Seth, Gupta, Lopa, Kirkwood, Katherine, Dobrev, Edlira, Levitan, Ron, O’Sullivan, Karen, Overbey, Jessica, Santos, Milerva, Williams, Deborah, Weglinski, Michael, Williams, Paula, Wood, Carrie, Ye, Xia, Nielsen, Sten Lyager, Wiggers, Henrik, Malgaard, Henning, Mack, Michael, Adame, Tracine, Settele, Natalie, Adams, Jenny, Ryan, William, Smith, Robert L., Grayburn, Paul, Chen, Frederick Y., Nohria, Anju, Cohn, Lawrence, Shekar, Prem, Aranki, Sary, Couper, Gregory, Davidson, Michael, Bolman, R. Morton, III, Burgess, Anne, Conboy, Debra, Lawrence, Rita, Noiseux, Nicolas, Stevens, Louis-Mathieu, Prieto, Ignacio, Basile, Fadi, Dionne, Joannie, Fecteau, Julie, Blackstone, Eugene H., Gillinov, A. Marc, Lackner, Pamela, Berroteran, Leoma, Dolney, Diana, Fleming, Suzanne, Palumbo, Roberta, Whitman, Christine, Sankovic, Kathy, Sweeney, Denise Kosty, Geither, Carrie, Doud, Kristen, Pattakos, Gregory, Clarke, Pamela A., Argenziano, Michael, Williams, Mathew, Goldsmith, Lyn, Smith, Craig R., Naka, Yoshifumi, Stewart, Allan, Schwartz, Allan, Bell, Daniel, Van Patten, Danielle, Sreekanth, Sowmya, Smith, Peter K., Alexander, John H., Milano, Carmelo A., Glower, Donald D., Mathew, Joseph P., Harrison, J. Kevin, Welsh, Stacey, Berry, Mark F., Parsa, Cyrus J., Tong, Betty C., Williams, Judson B., Ferguson, T. Bruce, Kypson, Alan P., Rodriguez, Evelio, Harris, Malissa, Akers, Brenda, O'Neal, Allison, Puskas, John D., Thourani, Vinod H., Guyton, Robert, Baer, Jefferson, Baio, Kim, Neill, Alexis A., Voisine, Pierre, Senechal, Mario, Dagenais, François, O’Connor, Kim, Dussault, Gladys, Ballivian, Tatiana, Keilani, Suzanne, Speir, Alan M., Magee, Patrick, Ad, Niv, Keyte, Sally, Dang, Minh, Slaughter, Mark, Headlee, Marsha, Moody, Heather, Solankhi, Naresh, Birks, Emma, Groh, Mark A., Shell, Leslie E., Shepard, Stephanie A., Trichon, Benjamin H., Nanney, Tracy, Hampton, Lynne C., Mangusan, Ralph, Michler, Robert E., D'Alessandro, David A., DeRose, Joseph J., Jr., Goldstein, Daniel J., Bello, Ricardo, Jakobleff, William, Garcia, Mario, Taub, Cynthia, Spevak, Daniel, Swayze, Roger, Sookraj, Nadia, Perrault, Louis P., Basmadjian, Arsène-Joseph, Bouchard, Denis, Carrier, Michel, Cartier, Raymond, Pellerin, Michel, Tanguay, Jean François, El-Hamamsy, Ismail, Denault, André, Demers, Philippe, Jonathan Lacharité, Sophie Robichaud, Horvath, Keith A., Corcoran, Philip C., Siegenthaler, Michael P., Murphy, Mandy, Iraola, Margaret, Greenberg, Ann, Sai-Sudhakar, Chittoor, Hasan, Ayseha, McDavid, Asia, Kinn, Bradley, Pagé, Pierre, Sirois, Carole, Latter, David, Leong-Poi, Howard, Bonneau, Daniel, Errett, Lee, Peterson, Mark D., Verma, Subodh, Feder-Elituv, Randi, Cohen, Gideon, Joyner, Campbell, Fremes, Stephen E., Moussa, Fuad, Christakis, George, Karkhanis, Reena, Yau, Terry, Farkouh, Michael, Woo, Anna, Cusimano, Robert James, David, Tirone, Feindel, Christopher, Garrard, Lisa, Fredericks, Suzanne, Mociornita, Amelia, Mullen, John C., Choy, Jonathan, Meyer, Steven, Kuurstra, Emily, Gammie, James S., Young, Cindi A., Beach, Dana, Villanueva, Robert, Acker, Michael A., Atluri, Pavan, Woo, Y. Joseph, Mayer, Mary Lou, Bowdish, Michael, Starnes, Vaughn A., Shavalle, David, Matthews, Ray, Javadifar, Shadi, Romar, Linda, Kron, Irving L., Ailawadi, Gorav, Johnston, Karen, Dent, John M., Kern, John, Keim, Jessica, Burks, Sandra, Gahring, Kim, Bull, David A., Desvigne-Nickens, Patrice, Dixon, Dennis O., Haigney, Mark, Holubkov, Richard, Jacobs, Alice, Miller, Frank, Murkin, John M., Spertus, John, Wechsler, Andrew S., Sellke, Frank, McDonald, Cheryl L., Byington, Robert, Dickert, Neal, Ikonomidis, John S., Williams, David O., Yancy, Clyde W., Fang, James C., Giannetti, Nadia, Richenbacher, Wayne, Rao, Vivek, Furie, Karen L., Miller, Rachel, Pinney, Sean, Roberts, William C., Walsh, Mary N., Hung, Judy, Zeng, Xin, Kilcullen, Niamh, Hung, David, Keteyian, Stephen J., Brawner, Clinton A., Aldred, Heather, Browndyke, Jeffrey, Toulgoat-Dubois, Yanne, Bertrand, Philippe B., Overbey, Jessica R., Levine, Robert A., Mack, Michael J., Giustino, Gennaro, and Bowdish, Michael E.

Published
2021
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12. Cost-effectiveness of coronary artery bypass grafting plus mitral valve repair versus coronary artery bypass grafting alone for moderate ischemic mitral regurgitation

Author

Miller, Marissa A., Taddei-Peters, Wendy C., Buxton, Dennis, Caulder, Ron, Geller, Nancy L., Gordon, David, Jeffries, Neal O., Lee, Albert, Moy, Claudia S., Gombos, Ilana Kogan, Ralph, Jennifer, Weisel, Richard, Gardner, Timothy J., O'Gara, Patrick T., Rose, Eric A., Gelijns, Annetine C., Parides, Michael K., Ascheim, Deborah D., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, Chang, Helena, Chase, Melissa, Chen, Yingchun, Goldfarb, Seth, Gupta, Lopa, Kirkwood, Katherine, Dobrev, Edlira, Levitan, Ron, O'Sullivan, Karen, Overbey, Jessica, Santos, Milerva, Weglinski, Michael, Williams, Paula, Wood, Carrie, Ye, Xia, Nielsen, Sten Lyager, Wiggers, Henrik, Malgaard, Henning, Mack, Michael, Adame, Tracine, Settele, Natalie, Adams, Jenny, Ryan, William, Smith, Robert L., Grayburn, Paul, Chen, Frederick Y., Nohria, Anju, Cohn, Lawrence, Shekar, Prem, Aranki, Sary, Couper, Gregory, Davidson, Michael, Bolman, R. Morton, III, Burgess, Anne, Conboy, Debra, Noiseux, Nicolas, Stevens, Louis-Mathieu, Prieto, Ignacio, Basile, Fadi, Dionne, Joannie, Fecteau, Julie, Blackstone, Eugene H., Gillinov, A. Marc, Lackner, Pamela, Berroteran, Leoma, Dolney, Diana, Fleming, Suzanne, Palumbo, Roberta, Whitman, Christine, Sankovic, Kathy, Sweeney, Denise Kosty, Pattakos, Gregory, Clarke, Pamela A., Argenziano, Michael, Williams, Mathew, Goldsmith, Lyn, Smith, Craig R., Naka, Yoshifumi, Stewart, Allan, Schwartz, Allan, Bell, Daniel, Van Patten, Danielle, Sreekanth, Sowmya, Smith, Peter K., Alexander, John H., Milano, Carmelo A., Glower, Donald D., Mathew, Joseph P., Harrison, J. Kevin, Welsh, Stacey, Berry, Mark F., Parsa, Cyrus J., Tong, Betty C., Williams, Judson B., Ferguson, T. Bruce, Kypson, Alan P., Rodriguez, Evelio, Harris, Malissa, Akers, Brenda, O'Neal, Allison, Puskas, John D., Thourani, Vinod H., Guyton, Robert, Baer, Jefferson, Baio, Kim, Neill, Alexis A., Voisine, Pierre, Senechal, Mario, Dagenais, François, O'Connor, Kim, Dussault, Gladys, Ballivian, Tatiana, Keilani, Suzanne, Speir, Alan M., Magee, Patrick, Ad, Niv, Keyte, Sally, Dang, Minh, Slaughter, Mark, Headlee, Marsha, Moody, Heather, Solankhi, Naresh, Birks, Emma, Groh, Mark A., Shell, Leslie E., Shepard, Stephanie A., Trichon, Benjamin H., Nanney, Tracy, Hampton, Lynne C., Michler, Robert E., D'Alessandro, David A., DeRose, Joseph J., Jr., Goldstein, Daniel J., Bello, Ricardo, Jakobleff, William, Garcia, Mario, Taub, Cynthia, Spevak, Daniel, Swayze, Roger, Perrault, Louis P., Basmadjian, Arsène-Joseph, Bouchard, Denis, Carrier, Michel, Cartier, Raymond, Pellerin, Michel, Tanguay, Jean François, El-Hamamsy, Ismail, Denault, André, Demers, Philippe, Robichaud, Sophie, Horvath, Keith A., Corcoran, Philip C., Siegenthaler, Michael P., Murphy, Mandy, Iraola, Margaret, Greenberg, Ann, Sai-Sudhakar, Chittoor, Hasan, Ayseha, McDavid, Asia, Kinn, Bradley, Pagé, Pierre, Sirois, Carole, Latter, David, Leong-Poi, Howard, Bonneau, Daniel, Errett, Lee, Peterson, Mark D., Verma, Subodh, Feder-Elituv, Randi, Cohen, Gideon, Joyner, Campbell, Fremes, Stephen E., Moussa, Fuad, Christakis, George, Karkhanis, Reena, Yau, Terry, Farkouh, Michael, Woo, Anna, Cusimano, Robert James, David, Tirone, Feindel, Christopher, Garrard, Lisa, Fredericks, Suzanne, Mociornita, Amelia, Mullen, John C., Choy, Jonathan, Meyer, Steven, Kuurstra, Emily, Gammie, James S., Young, Cindi A., Beach, Dana, Acker, Michael A., Atluri, Pavan, Woo, Y. Joseph, Mayer, Mary Lou, Bowdish, Michael, Starnes, Vaughn A., Shavalle, David, Matthews, Ray, Javadifar, Shadi, Romar, Linda, Kron, Irving L., Ailawadi, Gorav, Johnston, Karen, Dent, John M., Kern, John, Keim, Jessica, Burks, Sandra, Gahring, Kim, Bull, David A., Desvigne-Nickens, Patrice, Dixon, Dennis O., Haigney, Mark, Holubkov, Richard, Jacobs, Alice, Miller, Frank, Murkin, John M., Spertus, John, Wechsler, Andrew S., Sellke, Frank, McDonald, Cheryl L., Byington, Robert, Dickert, Neal, Ikonomidis, John S., Williams, David O., Yancy, Clyde W., Fang, James C., Giannetti, Nadia, Richenbacher, Wayne, Rao, Vivek, Furie, Karen L., Miller, Rachel, Pinney, Sean, Roberts, William C., Walsh, Mary N., Keteyian, Stephen J., Brawner, Clinton A., Aldred, Heather, Hung, Judy, Zeng, Xin, Browndyke, Jeffrey, Toulgoat-Dubois, Yanne, Ferket, Bart S., Hohmann, Samuel F., Chang, Helena L., Mick, Stephanie L., Hung, Judy W., Overbey, Jessica R., and Lala, Anuradha

Published
2020
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13. Canadian Cardiovascular Society/Canadian Cardiac Transplant Network Position Statement on Heart Transplantation: Patient Eligibility, Selection, and Post-Transplantation Care

Author

Chih, Sharon, McDonald, Michael, Dipchand, Anne, Kim, Daniel, Ducharme, Anique, Kaan, Annemarie, Abbey, Susan, Toma, Mustafa, Anderson, Kim, Davey, Ryan, Mielniczuk, Lisa, Campbell, Patricia, Zieroth, Shelley, Bourgault, Christine, Badiwala, Mitesh, Clarke, Brian, Belanger, Eric, Carrier, Michel, Conway, Jennifer, Doucette, Karen, Giannetti, Nadia, Isaac, Debra, MacArthur, Rod, and Senechal, Mario

Published
2020
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14. CCS/CHFS Heart Failure Guidelines: Clinical Trial Update on Functional Mitral Regurgitation, SGLT2 Inhibitors, ARNI in HFpEF, and Tafamidis in Amyloidosis

Author

O’Meara, Eileen, McDonald, Michael, Chan, Michael, Ducharme, Anique, Ezekowitz, Justin A., Giannetti, Nadia, Grzeslo, Adam, Heckman, George A., Howlett, Jonathan G., Koshman, Sheri L., Lepage, Serge, Mielniczuk, Lisa M., Moe, Gordon W., Swiggum, Elizabeth, Toma, Mustafa, Virani, Sean A., Zieroth, Shelley, De, Sabe, Matteau, Sylvain, Parent, Marie-Claude, Asgar, Anita W., Cohen, Gideon, Fine, Nowell, Davis, Margot, Verma, Subodh, Cherney, David, Abrams, Howard, Al-Hesayen, Abdul, Cohen-Solal, Alain, D’Astous, Michel, Delgado, Diego H., Desplantie, Olivier, Estrella-Holder, Estrellita, Green, Lee, Haddad, Haissam, Harkness, Karen, Hernandez, Adrian F., Kouz, Simon, LeBlanc, Marie-Hélène, Lee, Douglas, Masoudi, Frederick A., McKelvie, Robert S., Rajda, Miroslaw, Ross, Heather J., and Sussex, Bruce

Published
2020
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15. Management of Renin-Angiotensin-Aldosterone System blockade in patients admitted to hospital with confirmed coronavirus disease (COVID-19) infection (The McGill RAAS-COVID- 19): A structured summary of a study protocol for a randomized controlled trial

Author

Aflaki, Mona, Flannery, Alexandria, Ferreira, João Pedro, Cheng, Matthew Pellan, Kronfli, Nadine, Marelli, Ariane, Zannad, Faiez, Brophy, James, Afillalo, Jon, Huynh, Thao, Giannetti, Nadia, Bessissow, Amal, Ezekowitz, Justin A., Lopes, Renato D., Ambrosy, Andrew P., Craig, Morgan, and Sharma, Abhinav

Published
2021
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16. Pacemaker Implantation After Mitral Valve Surgery With Atrial Fibrillation Ablation

Author

Miller, Marissa A., Taddei-Peters, Wendy C., Buxton, Dennis, Connolly, Amy, Geller, Nancy L., Gordon, David, Jeffries, Neal O., Lee, Albert, Moy, Claudia S., Gombos, Ilana Kogan, Ralph, Jennifer, Weisel, Richard, Gardner, Timothy J., O’Gara, Patrick T., Rose, Eric A., Gelijns, Annetine C., Parides, Michael K., Ascheim, Deborah D., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, Chang, Helena, Chase, Melissa, Dobrev, Edlira, Goldfarb, Seth, Gupta, Lopa, Kirkwood, Katherine, Levitan, Ron, O’Sullivan, Karen, Overbey, Jessica, Santos, Milerva, Weglinski, Michael, Williams, Paula, Wood, Carrie, Ye, Xia, Mack, Michael, Adame, Tracine, Settele, Natalie, Adams, Jenny, Ryan, William, Smith, Robert L., Grayburn, Paul, Chen, Frederick Y., Nohria, Anju, Cohn, Lawrence, Shekar, Prem, Aranki, Sary, Couper, Gregory, Davidson, Michael, Bolman, R. Morton, III, Burgess, Anne, Conboy, Debra, Blackwell, Ray, Kerzner, Roger, Banbury, Michael, Squire, Andrea M., Gillinov, A. Marc, Blackstone, Eugene H., Lytle, Bruce, Mihaljevic, Tomislav, Lackner, Pamela, Berroteran, Leoma, Dolney, Diana, Fleming, Suzanne, Palumbo, Roberta, Whitman, Christine, Sankovic, Kathy, Sweeney, Denise Kosty, Pattakos, Gregory, Argenziano, Michael, Williams, Mathew, Goldsmith, Lyn, Smith, Craig R., Naka, Yoshifumi, Stewart, Allan, Schwartz, Allan, Bell, Daniel, Van Patten, Danielle, Sreekanth, Sowmya, Smith, Peter K., Alexander, John H., Milano, Carmelo A., Glower, Donald D., Mathew, Joseph P., Harrison, J. Kevin, Welsh, Stacey, Ferguson, T. Bruce, Kypson, Alan P., Rodriguez, Evelio, Harris, Malissa, Akers, Brenda, O'Neal, Allison, Puskas, John D., Thourani, Vinod H., Guyton, Robert, Baer, Jefferson, Baio, Kim, Neill, Alexis A., Voisine, Pierre, Senechal, Mario, Dagenais, François, O’Connor, Kim, Dussault, Gladys, Ballivian, Tatiana, Keilani, Suzanne, Michler, Robert E., D'Alessandro, David A., DeRose, Joseph J., Jr., Goldstein, Daniel J., Bello, Ricardo, Jakobleff, William, Garcia, Mario, Taub, Cynthia, Spevack, Daniel, Swayze, Roger, Sookraj, Nadia, Perrault, Louis P., Basmadjian, Arsène-Joseph, Bouchard, Denis, Carrier, Michel, Cartier, Raymond, Pellerin, Michel, Tanguay, Jean François, El-Hamamsy, Ismael, Denault, André, Lacharité, Jonathan, Robichaud, Sophie, Adams, David H., Varghese, Robin, Mandel-Portnoy, Yael, Horvath, Keith A., Corcoran, Philip C., Siegenthaler, Michael P., Murphy, Mandy, Iraola, Margaret, Greenberg, Ann, Sai-Sudhakar, Chittoor, Hasan, Ayseha, McDavid, Asia, Kinn, Bradley, Mullen, John C., Choy, Jonathan, Meyer, Steven, Kuurstra, Emily, Gammie, James S., DeFilippi, Christopher R., Gaetani, Dino T., Young, Cindi A., Beach, Dana, Collins, Julia, Bolling, Steven F., Pagani, Francis D., Bloem, Cathie, Acker, Michael A., Woo, Y. Joseph, Mayer, Mary Lou, Bavaria, Joseph E., Szeto, Wilson Y., Margulies, Kenneth, Keane, Martin, Glassberg, Helene, Jagasia, Dinesh, Kirkpatrick, James, Kron, Irving L., Ailawadi, Gorav, Johnston, Karen, Dent, John M., Kern, John, Keim, Jessica, Burks, Sandra, Gahring, Kim, Mangi, Abeel, Akar, Joseph, Yuh, David, Wilson, Lynn, Bull, David A., Desvigne-Nickens, Patrice, Dixon, Dennis O., Haigney, Mark, Holubkov, Richard, Jacobs, Alice, Miller, Frank, Murkin, John M., Spertus, John, Wechsler, Andrew S., Sellke, Frank, McDonald, Cheryl L., Byington, Robert, Dickert, Neal, Ikonomidis, John S., Williams, David O., Yancy, Clyde W., Canty, John M., Jr., Fang, James C., Giannetti, Nadia, Richenbacher, Wayne, Rao, Vivek, Furie, Karen L., Miller, Rachel, Pinney, Sean, Roberts, William C., Walsh, Mary N., Hung, Judy, Zeng, Xin, Couderc, Jean-Philippe, Balda, Dan, Bowen, Wayne, Wilson, Mauri, Schering, Anne, Mancini, Donna M., Chang, Helena L., Mack, Michael J., Yerokun, Babatunde A., Atluri, Pavan, Sledz, Nancy M., Tremblay, Hugo, Ferket, Bart S., and Iribarne, Alexander

Published
2019
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17. Spontaneous coronary artery dissection: a difficult journey from emergency coronary artery bypass grafting to left ventricular assist device.

Author

Ho, Daniel, Alfaris, Ibrahim, Joury, Abdulaziz, Cecere, Renzo, and Giannetti, Nadia

Subjects
EXTRACORPOREAL membrane oxygenation, MITRAL valve insufficiency, SPONTANEOUS coronary artery dissection, CARDIOGENIC shock, HEART assist devices, CORONARY artery bypass, ARTIFICIAL blood circulation, ACUTE coronary syndrome
Abstract

Background Excluding spontaneous coronary artery dissection (SCAD) as an aetiology of acute coronary syndrome in young adults is imperative. Case summary A previously healthy 39-year-old woman experienced sudden severe chest pain, ST-segment elevation on electrocardiogram, necessitating high-dose aspirin and urgent transfer to a revascularization centre. Suffering ventricular tachycardia (VT) and ventricular fibrillation (VF), she underwent two rounds of advanced life support and venoarterial extracorporeal membrane oxygenation. Diagnosed with left main coronary artery (LMCA) SCAD, she was initially started on conservative therapy for declining left ventricular ejection fraction. However, she continued to experience an escalating anginal symptoms, worsening biomarkers, and LMCA SCAD progression, which urged the need for surgical intervention with coronary artery bypass graft surgery (CABG). Following her CABG, she experienced a worsening of her functional mitral regurgitating, which she underwent transcatheter edge-to-edge repair of her severe mitral regurgitation. Despite being listed for orthotopic heart transplantation (OHTx), her low body mass index and elevated antibodies necessitated the HeartMate III left ventricular assist device (LVAD) for bridge to transplant. After treating frequent VT episodes with medications, she eventually received a LVAD as a bridge to cardiac transplantation. Within 1 year of her receiving LVAD, she underwent a successful OHTx. Discussion The pathogenesis of SCAD involves intramural haematoma formation through intimal tears or vasa vasorum haemorrhage. Adverse outcomes that could occur in SCAD patients include cardiac arrest, cardiogenic shock, reduced left ventricle systolic function, and occasionally serious cardiac arrhythmia—such as VF—which can lead to sudden cardiac death. Although most SCAD cases heal spontaneously, revascularization can be considered in case of worsening SCAD progression. Advanced therapeutic intervention including mechanical circulatory support and OHTx should be considered in refractory cases. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Predicting 1-Year Mortality in Outpatients With Heart Failure With Reduced Left Ventricular Ejection Fraction: Do Empiric Models Outperform Physician Intuitive Estimates? A Multicenter Cohort Study

Author

Alba, Ana C., primary, Buchan, Tayler A., additional, Saha, Sudipta, additional, Fan, Steve, additional, Demers, Catherine, additional, Poon, Stephanie, additional, Mak, Susanna, additional, Al-Hesayen, Abdul, additional, Toma, Mustafa, additional, Zieroth, Shelley, additional, Anderson, Kim, additional, Porepa, Liane, additional, Chih, Sharon, additional, Giannetti, Nadia, additional, Rac, Valeria, additional, Levy, Wayne C., additional, Ross, Heather J., additional, and Guyatt, Gordon H., additional

Published
2023
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21. 2017 Comprehensive Update of the Canadian Cardiovascular Society Guidelines for the Management of Heart Failure

Author

Ezekowitz, Justin A., O'Meara, Eileen, McDonald, Michael A., Abrams, Howard, Chan, Michael, Ducharme, Anique, Giannetti, Nadia, Grzeslo, Adam, Hamilton, Peter G., Heckman, George A., Howlett, Jonathan G., Koshman, Sheri L., Lepage, Serge, McKelvie, Robert S., Moe, Gordon W., Rajda, Miroslaw, Swiggum, Elizabeth, Virani, Sean A., Zieroth, Shelley, Al-Hesayen, Abdul, Cohen-Solal, Alain, D'Astous, Michel, De, Sabe, Estrella-Holder, Estrellita, Fremes, Stephen, Green, Lee, Haddad, Haissam, Harkness, Karen, Hernandez, Adrian F., Kouz, Simon, LeBlanc, Marie-Hélène, Masoudi, Frederick A., Ross, Heather J., Roussin, Andre, and Sussex, Bruce

Published
2017
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23. Comparison of Questionnaire and Performance‐Based Physical Frailty Scales to Predict Survival and Health‐Related Quality of Life in Patients With Heart Failure

Author

Somech, Joseph, primary, Joshi, Aayushi, additional, Mancini, Rita, additional, Chetrit, Jessica, additional, Michel, Caroline, additional, Sheppard, Richard, additional, Nguyen, Viviane, additional, Walker, Mathieu, additional, Giannetti, Nadia, additional, Sharma, Abhinav, additional, Maghakian, Delina, additional, Laforest, Esther, additional, and Afilalo, Jonathan, additional

Published
2023
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25. Measuring Single-Cell Calcium Dynamics Using a Myofilament-Localized Optical Biosensor in hiPSC-CMs Derived from DCM Patients.

Author

Hawey, Cara, Bourque, Kyla, Alim, Karima, Derish, Ida, Rody, Elise, Khan, Kashif, Gendron, Natalie, Cecere, Renzo, Giannetti, Nadia, and Hébert, Terence E.

Subjects
HEART, CALCIUM, MYOCARDIUM, DILATED cardiomyopathy, ELECTRIC stimulation, BIOSENSORS, TRANSIENT analysis
Abstract

Synchronized contractions of cardiomyocytes within the heart are tightly coupled to electrical stimulation known as excitation-contraction coupling. Calcium plays a key role in this process and dysregulated calcium handling can significantly impair cardiac function and lead to the development of cardiomyopathies and heart failure. Here, we describe a method and analytical technique to study myofilament-localized calcium signaling using the intensity-based fluorescent biosensor, RGECO-TnT. Dilated cardiomyopathy is a heart muscle disease that negatively impacts the heart's contractile function following dilatation of the left ventricle. We demonstrate how this biosensor can be used to characterize 2D hiPSC-CMs monolayers generated from a healthy control subject compared to two patients diagnosed with dilated cardiomyopathy. Lastly, we provide a step-by-step guide for single-cell data analysis and describe a custom Transient Analysis application, specifically designed to quantify features of calcium transients. All in all, we explain how this analytical approach can be applied to phenotype hiPSC-CM behaviours and stratify patient responses to identify perturbations in calcium signaling. [ABSTRACT FROM AUTHOR]

Published
2023
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26. The 2014 Canadian Cardiovascular Society Heart Failure Management Guidelines Focus Update: Anemia, Biomarkers, and Recent Therapeutic Trial Implications

Author

Moe, Gordon W., Ezekowitz, Justin A., O'Meara, Eileen, Lepage, Serge, Howlett, Jonathan G., Fremes, Steve, Al-Hesayen, Abdul, Heckman, George A., Abrams, Howard, Ducharme, Anique, Estrella-Holder, Estrellita, Grzeslo, Adam, Harkness, Karen, Koshman, Sheri L., McDonald, Michael, McKelvie, Robert, Rajda, Miroslaw, Rao, Vivek, Swiggum, Elizabeth, Virani, Sean, Zieroth, Shelley, Arnold, J.Malcolm O., Ashton, Tom, D'Astous, Michel, Chan, Michael, De, Sabe, Dorian, Paul, Giannetti, Nadia, Haddad, Haissam, Isaac, Debra L., Kouz, Simon, Leblanc, Marie-Hélène, Liu, Peter, Ross, Heather J., Sussex, Bruce, and White, Michel

Published
2015
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27. Effects of Empagliflozin in Women and Men With Heart Failure and Preserved Ejection Fraction

Author

Butler, Javed, primary, Filippatos, Gerasimos, additional, Siddiqi, Tariq Jamal, additional, Ferreira, João Pedro, additional, Brueckmann, Martina, additional, Bocchi, Edimar, additional, Böhm, Michael, additional, Chopra, Vijay K., additional, Giannetti, Nadia, additional, Iwata, Tomoko, additional, Januzzi, James L., additional, Kaul, Sanjay, additional, Piña, Ileana L., additional, Ponikowski, Piotr, additional, Rauch-Kröhnert, Ursula, additional, Shah, Sanjiv J., additional, Senni, Michele, additional, Sumin, Mikhail, additional, Verma, Subodh, additional, Zhang, Jian, additional, Pocock, Stuart J., additional, Zannad, Faiez, additional, Packer, Milton, additional, and Anker, Stefan D., additional

Published
2022
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28. Timing of Statistical Benefit of Mineralocorticoid Receptor Antagonists Among Patients With Heart Failure and Post-Myocardial Infarction

Author

Bedrouni, Wassim, primary, Sharma, Abhinav, additional, Pitt, Bertram, additional, Lam, Carolyn S.P., additional, Ni, Jiayi, additional, Ferreira, João Pedro, additional, McMurray, John, additional, Giannetti, Nadia, additional, Girerd, Nicolas, additional, Rossignol, Patrick, additional, Solomon, Scott D., additional, Claggett, Brian, additional, Pocock, Stuart, additional, Huynh, Thao, additional, and Zannad, Faiez, additional

Published
2022
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29. Effective use of genetically-encoded optical biosensors for profiling signalling signatures in iPSC-CMs derived from idiopathic dilated cardiomyopathy patients

Author

Bourque, Kyla, primary, Derish, Ida, additional, Hawey, Cara, additional, Jones-Tabah, Jace, additional, Khan, Kashif, additional, Alim, Karima, additional, Jiang, Alyson, additional, Sadighian, Hooman, additional, Zwaig, Jeremy, additional, Gendron, Natalie, additional, Cecere, Renzo, additional, Giannetti, Nadia, additional, and Hébert, Terence E., additional

Published
2022
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30. Mobile Health Fitness Applications: A Quantitative Analysis of Features and Barriers to Routine Use and Data Sharing Acceptability (Preprint)

Author

Razaghizad, Amir, primary, Malhame, Isabelle, additional, McKee, Turney, additional, Friedrich, Matthias, additional, Giannetti, Nadia, additional, Coristine, Andrew, additional, Johnson, Anders, additional, Ashley, Euan, additional, Hershman, Steven, additional, Struck, Brooke, additional, Krastev, Sekoul, additional, Pilat, Dan, additional, and Sharma, Abhinav, additional

Published
2022
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33. Clinical Prediction Models for Heart Failure Hospitalization in Type 2 Diabetes: A Systematic Review and Meta‐Analysis

Author

Razaghizad, Amir, primary, Oulousian, Emily, additional, Randhawa, Varinder Kaur, additional, Ferreira, João Pedro, additional, Brophy, James M., additional, Greene, Stephen J., additional, Guida, Julian, additional, Felker, G. Michael, additional, Fudim, Marat, additional, Tsoukas, Michael, additional, Peters, Tricia M., additional, Mavrakanas, Thomas A., additional, Giannetti, Nadia, additional, Ezekowitz, Justin, additional, and Sharma, Abhinav, additional

Published
2022
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36. The 2011 Canadian Cardiovascular Society Heart Failure Management Guidelines Update: Focus on Sleep Apnea, Renal Dysfunction, Mechanical Circulatory Support, and Palliative Care

Author

McKelvie, Robert S., Moe, Gordon W., Cheung, Anson, Costigan, Jeannine, Ducharme, Anique, Estrella-Holder, Estrellita, Ezekowitz, Justin A., Floras, John, Giannetti, Nadia, Grzeslo, Adam, Harkness, Karen, Heckman, George A., Howlett, Jonathan G., Kouz, Simon, Leblanc, Kori, Mann, Elizabeth, O'Meara, Eileen, Rajda, Miroslav, Rao, Vivek, Simon, Jessica, Swiggum, Elizabeth, Zieroth, Shelley, Arnold, J. Malcolm O., Ashton, Tom, D'Astous, Michel, Dorian, Paul, Haddad, Haissam, Isaac, Debra L., Leblanc, Marie-Hélène, Liu, Peter, Sussex, Bruce, and Ross, Heather J.

Published
2011
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38. Risk for non-home discharge following surgery for ischemic mitral valve disease

Author

Lala, Anuradha, primary, Chang, Helena L., additional, Liu, Xiaoyu, additional, Charles, Eric J., additional, Yerokun, Babatunde A., additional, Bowdish, Michael E., additional, Thourani, Vinod H., additional, Mack, Michael J., additional, Miller, Marissa A., additional, O'Gara, Patrick T., additional, Blackstone, Eugene H., additional, Moskowitz, Alan J., additional, Gelijns, Annetine C., additional, Mullen, John C., additional, Stevenson, Lynne W., additional, DeRose, Joseph J., additional, Wang, Alice, additional, Smith, Peter K., additional, Acker, Michael A., additional, Ailawadi, Gorav, additional, Taddei-Peters, Wendy C., additional, Buxton, Dennis, additional, Caulder, Ron, additional, Geller, Nancy L., additional, Gordon, David, additional, Jeffries, Neal O., additional, Lee, Albert, additional, Gombos, Ilana Kogan, additional, Ralph, Jennifer, additional, Weisel, Richard D., additional, Gardner, Timothy J., additional, Rose, Eric A., additional, Parides, Michael K., additional, Ascheim, Deborah D., additional, Bagiella, Emilia, additional, Moquete, Ellen, additional, Chang, Helena, additional, Chase, Melissa, additional, Foo, James, additional, Chen, Yingchun, additional, Goldfarb, Seth, additional, Gupta, Lopa, additional, Kirkwood, Katherine, additional, Dobrev, Edlira, additional, Levitan, Ron, additional, O'Sullivan, Karen, additional, Overbey, Jessica, additional, Santos, Milerva, additional, Williams, Deborah, additional, Weglinski, Michael, additional, Williams, Paula, additional, Wood, Carrie, additional, Ye, Xia, additional, Nielsen, Sten Lyager, additional, Wiggers, Henrik, additional, Malgaard, Henning, additional, Mack, Michael, additional, Adame, Tracine, additional, Settele, Natalie, additional, Adams, Jenny, additional, Ryan, William, additional, Smith, Robert L., additional, Grayburn, Paul, additional, Chen, Frederick Y., additional, Nohria, Anju, additional, Cohn, Lawrence, additional, Shekar, Prem, additional, Aranki, Sary, additional, Couper, Gregory, additional, Davidson, Michael, additional, Bolman, R. Morton, additional, Burgess, Anne, additional, Conboy, Debra, additional, Lawrence, Rita, additional, Noiseux, Nicolas, additional, Stevens, Louis-Mathieu, additional, Prieto, Ignacio, additional, Basile, Fadi, additional, Dionne, Joannie, additional, Fecteau, Julie, additional, Gillinov, A. Marc, additional, Lackner, Pamela, additional, Berroteran, Leoma, additional, Dolney, Diana, additional, Fleming, Suzanne, additional, Palumbo, Roberta, additional, Whitman, Christine, additional, Sankovic, Kathy, additional, Sweeney, Denise Kosty, additional, Geither, Carrie, additional, Doud, Kristen, additional, Pattakos, Gregory, additional, Clarke, Pamela A., additional, Argenziano, Michael, additional, Williams, Mathew, additional, Goldsmith, Lyn, additional, Smith, Craig R., additional, Naka, Yoshifumi, additional, Stewart, Allan, additional, Schwartz, Allan, additional, Bell, Daniel, additional, Van Patten, Danielle, additional, Sreekanth, Sowmya, additional, Alexander, John H., additional, Milano, Carmelo A., additional, Glower, Donald D., additional, Mathew, Joseph P., additional, Harrison, J. Kevin, additional, Welsh, Stacey, additional, Berry, Mark F., additional, Parsa, Cyrus J., additional, Tong, Betty C., additional, Williams, Judson B., additional, Ferguson, T. Bruce, additional, Kypson, Alan P., additional, Rodriguez, Evelio, additional, Harris, Malissa, additional, Akers, Brenda, additional, O'Neal, Allison, additional, Puskas, John D., additional, Guyton, Robert, additional, Baer, Jefferson, additional, Baio, Kim, additional, Neill, Alexis A., additional, Voisine, Pierre, additional, Senechal, Mario, additional, Dagenais, François, additional, O'Connor, Kim, additional, Dussault, Gladys, additional, Ballivian, Tatiana, additional, Keilani, Suzanne, additional, Speir, Alan M., additional, Magee, Patrick, additional, Ad, Niv, additional, Keyte, Sally, additional, Dang, Minh, additional, Slaughter, Mark, additional, Headlee, Marsha, additional, Moody, Heather, additional, Solankhi, Naresh, additional, Birks, Emma, additional, Groh, Mark A., additional, Shell, Leslie E., additional, Shepard, Stephanie A., additional, Trichon, Benjamin H., additional, Nanney, Tracy, additional, Hampton, Lynne C., additional, Mangusan, Ralph, additional, Michler, Robert E., additional, D'Alessandro, David A., additional, Goldstein, Daniel J., additional, Bello, Ricardo, additional, Jakobleff, William, additional, Garcia, Mario, additional, Taub, Cynthia, additional, Spevak, Daniel, additional, Swayze, Roger, additional, Sookraj, Nadia, additional, Perrault, Louis P., additional, Basmadjian, Arsène-Joseph, additional, Bouchard, Denis, additional, Carrier, Michel, additional, Cartier, Raymond, additional, Pellerin, Michel, additional, Tanguay, Jean François, additional, El-Hamamsy, Ismail, additional, Denault, André, additional, Demers, Philippe, additional, Jonathan Lacharité, Sophie Robichaud, additional, Horvath, Keith A., additional, Corcoran, Philip C., additional, Siegenthaler, Michael P., additional, Murphy, Mandy, additional, Iraola, Margaret, additional, Greenberg, Ann, additional, Sai-Sudhakar, Chittoor, additional, Hasan, Ayseha, additional, McDavid, Asia, additional, Kinn, Bradley, additional, Pagé, Pierre, additional, Sirois, Carole, additional, Latter, David, additional, Leong-Poi, Howard, additional, Bonneau, Daniel, additional, Errett, Lee, additional, Peterson, Mark D., additional, Verma, Subodh, additional, Feder-Elituv, Randi, additional, Cohen, Gideon, additional, Joyner, Campbell, additional, Fremes, Stephen E., additional, Moussa, Fuad, additional, Christakis, George, additional, Karkhanis, Reena, additional, Yau, Terry, additional, Farkouh, Michael, additional, Woo, Anna, additional, Cusimano, Robert James, additional, David, Tirone, additional, Feindel, Christopher, additional, Garrard, Lisa, additional, Fredericks, Suzanne, additional, Mociornita, Amelia, additional, Choy, Jonathan, additional, Meyer, Steven, additional, Kuurstra, Emily, additional, Gammie, James S., additional, Young, Cindi A., additional, Beach, Dana, additional, Villanueva, Robert, additional, Atluri, Pavan, additional, Woo, Y. Joseph, additional, Mayer, Mary Lou, additional, Bowdish, Michael, additional, Starnes, Vaughn A., additional, Shavalle, David, additional, Matthews, Ray, additional, Javadifar, Shadi, additional, Romar, Linda, additional, Kron, Irving L., additional, Johnston, Karen, additional, Dent, John M., additional, Kern, John, additional, Keim, Jessica, additional, Burks, Sandra, additional, Gahring, Kim, additional, Bull, David A., additional, Dixon, Dennis O., additional, Haigney, Mark, additional, Holubkov, Richard, additional, Jacobs, Alice, additional, Miller, Frank, additional, Murkin, John M., additional, Spertus, John, additional, Wechsler, Andrew S., additional, Sellke, Frank, additional, Byington, Robert, additional, Dickert, Neal, additional, Ikonomidis, John S., additional, Williams, David O., additional, Yancy, Clyde W., additional, Fang, James C., additional, Giannetti, Nadia, additional, Richenbacher, Wayne, additional, Rao, Vivek, additional, Furie, Karen L., additional, Miller, Rachel, additional, Pinney, Sean, additional, Roberts, William C., additional, Walsh, Mary N., additional, Hung, Judy, additional, Zeng, Xin, additional, Kilcullen, Niamh, additional, Hung, David, additional, Keteyian, Stephen J., additional, Brawner, Clinton A., additional, Aldred, Heather, additional, Browndyke, Jeffrey, additional, and Toulgoat-Dubois, Yanne, additional

Published
2021
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40. The 2010 Canadian Cardiovascular Society guidelines for the diagnosis and management of heart failure update: Heart failure in ethnic minority populations, heart failure and pregnancy, disease management, and quality improvement/assurance programs

Author

Howlett, Jonathan G., McKelvie, Robert S., Costigan, Jeannine, Ducharme, Anique, Estrella-Holder, Estrellita, Ezekowitz, Justin A., Giannetti, Nadia, Haddad, Haissam, Heckman, George A., Herd, Anthony M., Isaac, Debra, Kouz, Simon, Leblanc, Kori, Liu, Peter, Mann, Elizabeth, Moe, Gordon W., O’Meara, Eileen, Rajda, Miroslav, Siu, Samuel, Stolee, Paul, Swiggum, Elizabeth, and Zeiroth, Shelley

Published
2010
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41. Abstract 9009: Management of Renin-Angiotensin-Aldosterone System Blockade in Patients Admitted in Hospital With Confirmed Coronavirus Disease (COVID-19) Infection: The McGill RAAS-COVID-19 Randomized Controlled Trial

Author

Sharma, Abhinav, primary, Elharram, Malik, additional, Ni, Jiayi, additional, Afilalo, Jonathan, additional, Flannery, RN, Alexandria, additional, Ezekowitz, Justin, additional, Cheng, Matthew P, additional, Ambrosy, Andrew P, additional, ZANNAD, Faiez, additional, Brophy, Jay, additional, Giannetti, Nadia, additional, Bessissow, Amal, additional, Kronfli, Nadine, additional, Marelli, Ariane J, additional, Aziz, Haya, additional, AlQahtani, Mohammad, additional, Aflaki, Mona, additional, Craig, Morgan, additional, Lopes, Renato D, additional, and Ferreira, Joao P, additional

Published
2021
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42. Empagliflozin in Heart Failure with a Preserved Ejection Fraction

Author

Anker, Stefan D., primary, Butler, Javed, additional, Filippatos, Gerasimos, additional, Ferreira, João P., additional, Bocchi, Edimar, additional, Böhm, Michael, additional, Brunner–La Rocca, Hans-Peter, additional, Choi, Dong-Ju, additional, Chopra, Vijay, additional, Chuquiure-Valenzuela, Eduardo, additional, Giannetti, Nadia, additional, Gomez-Mesa, Juan Esteban, additional, Janssens, Stefan, additional, Januzzi, James L., additional, Gonzalez-Juanatey, Jose R., additional, Merkely, Bela, additional, Nicholls, Stephen J., additional, Perrone, Sergio V., additional, Piña, Ileana L., additional, Ponikowski, Piotr, additional, Senni, Michele, additional, Sim, David, additional, Spinar, Jindrich, additional, Squire, Iain, additional, Taddei, Stefano, additional, Tsutsui, Hiroyuki, additional, Verma, Subodh, additional, Vinereanu, Dragos, additional, Zhang, Jian, additional, Carson, Peter, additional, Lam, Carolyn Su Ping, additional, Marx, Nikolaus, additional, Zeller, Cordula, additional, Sattar, Naveed, additional, Jamal, Waheed, additional, Schnaidt, Sven, additional, Schnee, Janet M., additional, Brueckmann, Martina, additional, Pocock, Stuart J., additional, Zannad, Faiez, additional, and Packer, Milton, additional

Published
2021
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44. Canadian Cardiovascular Society Consensus Conference guidelines on heart failure, update 2009: Diagnosis and management of right-sided heart failure, myocarditis, device therapy and recent important clinical trials

Author

Howlett, Jonathan G., McKelvie, Robert S., Arnold, J Malcolm O., Costigan, Jeannine, Dorian, Paul, Ducharme, Anique, Estrella-Holder, Estrellita, Ezekowitz, Justin A., Giannetti, Nadia, Haddad, Haissam, Heckman, George A., Herd, Anthony M., Isaac, Debra, Jong, Philip, Kouz, Simon, Liu, Peter, Mann, Elizabeth, Moe, Gordon W., Tsuyuki, Ross T., Ross, Heather J., and White, Michel

Published
2009
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46. Empagliflozin and health-related quality of life outcomes in patients with heart failure with reduced ejection fraction: the EMPEROR-Reduced trial

Author

Butler, Javed, Anker, Stefan D, Filippatos, Gerasimos, Khan, Muhammad Shahzeb, Ferreira, João Pedro, Pocock, Stuart J, Giannetti, Nadia, Januzzi, James L, Piña, Ileana L, Lam, Carolyn SP, Ponikowski, Piotr, Sattar, Naveed, Verma, Subodh, Brueckmann, Martina, Jamal, Waheed, Vedin, Ola, Peil, Barbara, Zeller, Cordula, Zannad, Faiez, Packer, Milton, and EMPEROR-Reduced Trial Committees and Investigators

Abstract

AIMS: In this secondary analysis of the EMPEROR-Reduced trial, we sought to evaluate whether the benefits of empagliflozin varied by baseline health status and how empagliflozin impacted patient-reported outcomes in patients with heart failure with reduced ejection fraction. METHODS AND RESULTS: Health status was assessed by the Kansas City Cardiomyopathy Questionnaires-clinical summary score (KCCQ-CSS). The influence of baseline KCCQ-CSS (analyzed by tertiles) on the effect of empagliflozin on major outcomes was examined using Cox proportional hazards models. Responder analyses were performed to assess the odds of improvement and deterioration in KCCQ scores related to treatment with empagliflozin. Empagliflozin reduced the primary outcome of cardiovascular death or heart failure hospitalization regardless of baseline KCCQ-CSS tertiles [hazard ratio (HR) 0.83 (0.68-1.02), HR 0.74 (0.58-0.94), and HR 0.61 (0.46-0.82) for

Published
2021

47. Empagliflozin in Heart Failure with a Preserved Ejection Fraction

Author

Anker, Stefan D. Butler, Javed Filippatos, Gerasimos and Ferreira, Joao P. Bocchi, Edimar Boehm, Michael Brunner-La Rocca, Hans-Peter Choi, Dong-Ju Chopra, Vijay and Chuquiure-Valenzuela, Eduardo Giannetti, Nadia Gomez-Mesa, Juan Esteban Janssens, Stefan Januzzi, James L. and Gonzalez-Juanatey, Jose R. Merkely, Bela Nicholls, Stephen J. and Perrone, Sergio V. Pina, Ileana L. Ponikowski, Piotr and Senni, Michele Sim, David Spinar, Jindrich Squire, Iain and Taddei, Stefano Tsutsui, Hiroyuki Verma, Subodh Vinereanu, Dragos Zhang, Jian Carson, Peter Lam, Carolyn Su Ping and Marx, Nikolaus Zeller, Cordula Sattar, Naveed Jamal, Waheed and Schnaidt, Sven Schnee, Janet M. Brueckmann, Martina and Pocock, Stuart J. Zannad, Faiez Packer, Milton EMPEROR Preserved Trial

Abstract

BACKGROUND Sodium-glucose cotransporter 2 inhibitors reduce the risk of hospitalization for heart failure in patients with heart failure and a reduced ejection fraction, but their effects in patients with heart failure and a preserved ejection fraction are uncertain. METHODS In this double-blind trial, we randomly assigned 5988 patients with class II-IV heart failure and an ejection fraction of more than 40% to receive empagliflozin (10 mg once daily) or placebo, in addition to usual therapy. The primary outcome was a composite of cardiovascular death or hospitalization for heart failure. RESULTS Over a median of 26.2 months, a primary outcome event occurred in 415 of 2997 patients (13.8%) in the empagliflozin group and in 511 of 2991 patients (17.1%) in the placebo group (hazard ratio, 0.79; 95% confidence interval [CI], 0.69 to 0.90; P

Published
2021

49. Canadian Cardiovascular Society Consensus Conference guidelines on heart failure – 2008 update: Best practices for the transition of care of heart failure patients, and the recognition, investigation and treatment of cardiomyopathies

Author

Arnold, J. Malcolm O., Howlett, Jonathan G., Ducharme, Anique, Ezekowitz, Justin A., Gardner, Martin J., Giannetti, Nadia, Haddad, Haissam, Heckman, George A., Isaac, Debra, Jong, Philip, Liu, Peter, Mann, Elizabeth, McKelvie, Robert S., Moe, Gordon W., Svendsen, Anna M., Tsuyuki, Ross T., O’Halloran, Kelly, Ross, Heather J., Sequeira, Errol J., and White, Michel

Published
2008
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