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Background: Autoimmune gastritis (AIG) is an infrequent disease predisposing to both neuroendocrine tumours and cancer. This study aimed to evaluate whether pH measurement of gastric juice allows accurate exclusion of the presence of AIG in real time so that gastric mucosa sampling on normal-appearing mucosa may be avoided. Methods: This study enrolled patients diagnosed with AIG and matched controls (ratio 1:5) who underwent upper endoscopy with standard gastric mucosa sampling and real-time, gastric juice pH assessment. A threshold of pH less than 4.5 was adopted as cut-off to rule out the presence of a feature of AIG. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), overall accuracy, positive likelihood ratio (LR+), and negative likelihood ratio (LR−) were calculated. Results: Data of 40 patients (M/F: 19/21; mean age: 58 years, range: 18–89) with AIG and 212 matched controls were evaluated. Among AIG patients, the feature of atrophy/metaplasia of the oxyntic mucosa was staged as mild in 9 cases, moderate in 9, and severe in the remaining 22 patients. Gastric juice analysis showed a pH value >4.5 in 29 (72.5%) patients and 12 (5.7%) controls. Sensitivity, specificity, accuracy, PPV, NPV, LR+, and LR− were 73% (95% CI = 0.57–0.84), 94% (95% CI = 0.90–0.97), 71% (95% CI = 0.64–0.74), 95% (95% CI = 0.93–0.97), 91% (95% CI = 0.87–0.95), 12.9 (95% CI = 7.19–23.03), and 0.29 (95% CI = 0.18–0.48), respectively. The histological assessment of false-negative cases showed the presence of only mild-moderate atrophy of oxyntic mucosa in 6 (54.5%) cases, and severe in the others. Conclusions: Our data found that real-time pH evaluation of gastric juice allows ruling out AIG with a very high NPV, but further studies are needed.

Abstract Background Unique interpersonal synchrony occurs during every social interaction, and is shaped by characteristics of participating individuals in these social contexts. Additionally, depending on context demands, interpersonal synchrony is also altered. The study therefore aims to investigate culture, sex, and social context effects simultaneously in a novel role-play paradigm. Additionally, the effect of personality traits on synchrony was investigated across cultures, and a further exploratory analysis on the effects of these variables on pre- and post-session empathy changes was conducted. Methods 83 dyads were recruited in two waves from Singapore and Italy and took part in a within-subjects session where they interacted with each other as themselves (Naturalistic Conversation) and as others (Role-Play and Role Reversal). Big Five Inventory (administered pre-session) and Interpersonal Reactivity Index (administered pre- and post-session) were used as measures of personality and empathy respectively, while synchrony was measured using hyperscanning functional near-infrared spectroscopy in the prefrontal cortex. After data-preprocessing and preliminary analyses, a mixture of multiple linear regression and exploratory forward stepwise regression models were used to address the above study aims. Results Results revealed significant main and interaction effects of culture, sex and social context on brain-to-brain synchrony, particularly in the medial left cluster of the prefrontal cortex, and a unique contribution of extraversion and openness to experience to synchrony in the Italian cohort only. Finally, culture-driven differences in empathy changes were identified, where significant increases in empathy across sessions were generally only observed within the Singaporean cohort. Conclusions Main findings indicate lowered brain-to-brain synchrony during role-playing activities that is moderated by the dyad’s sex make-up and culture, implying differential processing of social interactions that is also influenced by individuals’ background factors. Findings align with current literature that role-playing is a cognitively demanding activity requiring greater levels of self-regulation and suppression of self-related cognition as opposed to interpersonal co-regulation characterized by synchrony. However, the current pattern of results would be better supported by future studies investigating multimodal synchronies and corroboration.

Captagon is a synthetic stimulant combining amphetamine and theophylline. Initially introduced in 1961 as a treatment for hyperactivity, depression, and narcolepsy, Captagon was later classified as a Schedule 1 controlled substance due to its addictive and hallucinogenic properties. Despite its global prohibition in 1986, the trade of counterfeit products is widespread, especially in south-east Europe and far-east Asia, with its production being on the rise in Middle Eastern regions. This paper presents a quantitative data-driven bibliometric analysis of the existing literature on Captagon up to July 2024. It aims to delineate the structure and development of knowledge surrounding the substance, including key contributing countries, authors, prominent sources, and recurring thematic keywords. The quantitative and data-driven results were then used to guide the narrative discussion on Captagon. Findings indicate that current research predominantly focuses on Captagon’s use and impact in conflict zones, often exploring its interaction with other substances used by civilians and militias. Results also show a growing trend in Captagon research, with Saudi Arabia, Jordan, and Iraq emerging as main contributors to the literature. Despite the attention in specific regions, a considerable gap remains in understanding the mechanisms of action of Captagon (particularly regarding its metabolism, toxicology, mortality risk), and in developing protocols for its discontinuation. Additionally, the drug’s inconsistent composition requires further analyses to better predict risks and establish effective management strategies. Addressing these gaps will be crucial for the development of novel interventions and policies to mitigate the adverse effects of Captagon and improve public health systems worldwide.

Sleep is a complex state which involves interactions between neurophysiological, psychological and neurochemical processes which in turn have an important impact on brain functioning, immune responses, mental health, and quality of life. The incidence of Adverse Childhood Experiences (ACEs) varies across different countries and have been linked with lifespan sleep disturbances with further effects on people's physical and mental health functioning. This review aims to explore the significance of ACE and its impact on sleep by identifying key documents, thematic trends, and knowledge gaps in the literature. A document co-citation analysis of 882 documents from Scopus was conducted to achieve this goal. Research trends focused on the long-term consequences of childhood adverse events with respect to sleep, with emphasis on the role of type, timing and accumulation of these experiences. A recent study has also taken advantage of machine learning and network analysis for discovering essential factors could offer useful information about adults with history of childhood adversity and sleep problems. The studies show unanimously that ACEs are associated with multiple sleep disturbances/disorders which can persist into adulthood, with consequences for suboptimal cognitive and behavioral functioning. Such neurobiological scars can be associated with an increased risk of mental disorders. Future studies are needed that focus on longitudinal analysis of the relationship between early adversity, sleep, and resilience characteristics in adult populations exploring the use of objective assessment measures as well as neurobiological markers.

Interpersonal synchrony is a crucial construct in understanding social interactions, which has been used in clinical studies to measure the quality of the therapeutic alliance. However, there is a lack of studies investigating the correlation between synchrony expressed on different levels: behavioural and neurophysiological. Furthermore, there are no studies that examine how the implementation of psychodramatic role-playing techniques, when individuals adopt the persona of a different character, may influence intrinsic biobehavioural synchrony between two parties. The present study, therefore, aims to uncover the relationship between behavioural and brain-to-brain synchrony across different role-playing techniques and elucidate the impact of these synchronies on participants’ levels of anxiety and empathy. By using functional near-infrared imaging and behavioural coding in a dyadic role-playing paradigm (n = 41 dyads), the study found correlations between behavioural and brain-to-brain synchrony during naturalistic conversations, but not during role-play, implying a qualitative change in interpersonal synchrony when implementing role-playing techniques. Additionally, the study noted significant contributions of both behavioural and brain-to-brain synchrony as well as peripheral factors such as dyadic sex make-up and role immersion in predicting dyadic anxiety and empathy changes. Findings call for future studies to consider role-playing scenarios as a qualitatively different form of social interaction.

Anxiety disorders represent a prevalent mental health concern, with escalating rates, especially among emerging adults. University students, in particular, face a myriad of academic and life stressors that can amplify feelings of worry and anxiety. While early parental bonding seem to predict anxiety disorders later in life, the applicability to emerging adult students and its applicability to predict sub-clinical and transdiagnostic anxiety features remain unclear. This study aims to examine i) the relationship between demographic variables and key features of anxiety disorders (i.e., worry and anxiety symptoms); and ii) the predictive association between early parental bonding and anxiety-related features. A sample of 370 university students in Italy (n = 279 females; M age = 20.84 years, SD age = 1.81 years) completed the Parental Bonding Instrument, the Penn State Worry Questionnaire, and the Beck Anxiety Inventory. Females reported higher levels of worry and anxiety compared to males. Significantly higher worry and anxiety symptoms were reported by individuals who experienced affectionless control (low care and high overprotection) as compared to those exposed to optimal parenting (high care and low overprotection). Predictive models indicated that scores of parental care (i.e., the principal component between maternal and paternal care scores) and parental overprotection (i.e., the principal component between maternal and paternal overprotection scores) are robust predictors of worry and anxiety symptoms. However, this relationship showed a gender-specific pattern: lower parental care was more significant in predicting anxiety features in males, while high overprotection was more significant in females. The findings contribute to the comprehension of the risk factors influencing the susceptibility of emerging adult students to anxiety disorders.

BackgroundImage and Performance-Enhancing Drugs (IPEDs) can enhance mental and physical capabilities and impact one’s overall health. Initially confined in sport environments, IPEDs use has become increasingly widespread in a high-performing society. The present study was aimed at profiling IPEDs use during the COVID-19 lockdown among an international sample of young adults.MethodsA cross-sectional observational study was carried out in eight countries (United Kingdom, Italy, Lithuania, Hungary, Portugal, Spain, Brazil, and Japan) between April and May 2020. The survey questionnaire included validated measurements such as Exercise Addiction Inventory (EAI), Appearance Anxiety Inventory (AAI), and Self-Compassion Scale (SCS) as well as questions about the type of IPEDs, purchasing methods and socio-demographic information.ResultsA total of 736 IPEDs users were included in the survey. Their mean age was 33.05 years (±SD = 10.06), and 64.2% were female participants. Overall, 6.8% were found at risk of exercise addiction (EAI >24), 27.6% presented high levels of appearance anxiety, and 24.9% revealed low levels of emotional regulation’s self-compassion. Most participants (55.6%) purchased IPEDs through pharmacies/specialized shops, while 41.3% purchased IPEDs on the Internet. Online IPEDs buyers were mainly men who had higher scores on the Exercise Addiction Inventory. One or more IPEDs classifiable as “potentially risky” were used by 66.3% of the sample. Users of “potentially risky IPEDs” were younger and primarily men. They showed higher scores both on the Exercise Addiction Inventory and Appearance Anxiety Inventory.ConclusionThis study profiled users of IPEDs when the most restrictive COVID-19 lockdown policies were implemented in all the participating countries. More targeted post-COVID 19 prevention strategies should be implemented according to the emerged socio-demographic and psychopathological traits and cross-cultural differences emerged. Longitudinal studies will also be needed to determine the long-term effect of the COVID-19 lockdown on IPEDs consumption.

Abstract Children’s secure attachment with their primary caregivers is crucial for physical, cognitive, and emotional maturation. Yet, the causal links between specific parenting behaviors and infant attachment patterns are not fully understood. Here we report infant attachment in New World monkeys common marmosets, characterized by shared infant care among parents and older siblings and complex vocal communications. By integrating natural variations in parenting styles and subsecond-scale microanalyses of dyadic vocal and physical interactions, we demonstrate that marmoset infants signal their needs through context-dependent call use and selective approaches toward familiar caregivers. The infant attachment behaviors are tuned to each caregiver’s parenting style; infants use negative calls when carried by rejecting caregivers and selectively avoid neglectful and rejecting caregivers. Family-deprived infants fail to develop such adaptive uses of attachment behaviors. With these similarities with humans, marmosets offer a promising model for investigating the biological mechanisms of attachment security.

Introduction: Immune checkpoint inhibitors are new drugs approved for the treatment of many types of malignancies. Despite their wide use and unquestionable clinical benefits, these agents have also been associated with a unique spectrum of side effects known as immune-related adverse events. In this study, we report the first case of atezolizumab-induced pustular psoriasis and acrodermatitis. Case Presentation: A 61-year-old woman presented to our department with erythematous-desquamative and pustular lesions involving all hands and feet fingers, inguinal region, and trunk, associated to severe psoriatic onychodystrophy. She was affected by non-small-cell lung carcinoma from 12 years, and 7 months before admission, she started a treatment with atezolizumab. Conclusion: Immune checkpoint inhibitors such as atezolizumab are linked to a plethora of adverse events. Identifying and treating certain adverse skin events, particularly in cancer patients, can be a challenge, leading oncologists to discontinue immunotherapy. Our case shows how it is necessary to have a shared therapeutic algorithm in order to manage serious skin reactions in cancer patients and avoid disruption of the oncotherapy.

Functional near-infrared spectroscopy (fNIRS) is an increasingly popular tool for cross-cultural neuroimaging studies. However, the reproducibility and comparability of fNIRS studies is still an open issue in the scientific community. The paucity of experimental practices and the lack of clear guidelines regarding fNIRS use contribute to undermining the reproducibility of results. For this reason, much effort is now directed at assessing the impact of heterogeneous experimental practices in creating divergent fNIRS results. The current work aims to assess differences in fNIRS signal quality in data collected by two different labs in two different cohorts: Singapore (N=74) and Italy (N=84). Random segments of 20s were extracted from each channel in each participant’s NIRScap and 1280 deep features were obtained using a deep learning model trained to classify the quality of fNIRS data. Two datasets were generated: ALL dataset (segments with bad and good data quality) and GOOD dataset (segments with good quality). Each dataset was divided into train and test partitions, which were used to train and evaluate the performance of a Support Vector Machine (SVM) model in classifying the cohorts from signal quality features. Results showed that the SG cohort had significantly higher occurrences of bad signal quality in the majority of the fNIRS channels. Moreover, the SVM correctly classified the cohorts when using the ALL dataset. However, the performance dropped almost completely (except for five channels) when the SVM had to classify the cohorts using data from the GOOD dataset. These results suggest that fNIRS raw data obtained by different labs might possess different levels of quality as well as different latent characteristics beyond quality per se. The current study highlights the importance of defining clear guidelines in the conduction of fNIRS experiments in the reporting of data quality in fNIRS manuscripts.

Abstract Sexism is a widespread form of gender discrimination, which can take the form of criticism towards women based on gender stereotypes. However, little is known about how perceived criticism and sexism shape one’s construal of criticism from various interpersonal sources. The present study investigated whether perceived criticism, perceived sexism and the source of criticism (mother, father, workplace supervisor, romantic partner) interact to influence upset levels in response to criticism. 178 participants completed perceived criticism (PC) ratings for the four relationships and 95 female participants also completed the Schedule of Sexist Events scale. Participants read experimental vignettes describing scenarios of criticism from different sources and rated how upset they would feel in each scenario. Perceived sexism significantly moderated the effect of PC on upset levels only for sexist-related criticism from romantic partners and supervisors. Female participants with low perceived sexism show higher levels of upset as PC increased for sexist-related criticism from supervisors whereas female participants with high perceived sexism show lower levels of upset as PC increased for sexist-related criticism from romantic partners. These findings contribute towards understanding how perceived criticism and perceived sexism influence affective reactions to criticism across interpersonal sources.

Gastric cancer (GC) is a significant healthcare concern, and the identification of high-risk patients is crucial. Indeed, gastric precancerous conditions present significant diagnostic challenges, particularly early intestinal metaplasia (IM) detection. This study developed a deep learning system to assist in IM detection using image patches from gastric corpus examined using virtual chromoendoscopy in a Western country. Utilizing a retrospective dataset of endoscopic images from Sant’Andrea University Hospital of Rome, collected between January 2020 and December 2023, the system extracted 200 × 200 pixel patches, classifying them with a voting scheme. The specificity and sensitivity on the patch test set were 76% and 72%, respectively. The optimization of a learnable voting scheme on a validation set achieved a specificity of 70% and sensitivity of 100% for entire images. Despite data limitations and the absence of pre-trained models, the system shows promising results for preliminary screening in gastric precancerous condition diagnostics, providing an explainable and robust Artificial Intelligence approach.

Gastric neuroendocrine neoplasms (g-NENs) are rare tumors arising from the gastric enterochromaffin-like cells. Recent data suggests an increased detection rate, attributed to more frequent esophagogastroduodenoscopies. While type 3 g-NENs were historically deemed aggressive, emerging research indicates potential for conservative management, especially endoscopic resection, in well-differentiated, small tumors. European guidelines now advocate for endoscopic intervention in selected cases, but North American guidelines remain more conservative. Key factors influencing outcomes are tumor size, grading, and depth of gastric wall infiltration. Endoscopic resection has shown promise for tumors confined to submucosal layers without lymphovascular invasion. Given the complexities, a multidisciplinary team approach is essential for management decisions. Current insights are largely based on retrospective studies, underscoring the need for prospective research to optimize endoscopic approaches.

ABSTRACTThis paper presents a novel geodiversity map of the Abruzzo, Lazio, and Molise National Park (Central Italy). The Park exhibits a wide range of geological-geomorphological environments of great scientific and touristic interest, offering unique landscapes and wild nature frequented by visitors year-around. All these features reflect a marked geodiversity and a valuable geoheritage, requiring protection and valorization activities. The geodiversity map that we present was realized following an integrated methodological approach, which includes and combines geological-geomorphological features, geoheritage elements, data from Park archives, and new field-based observations. In this framework, the map serves as a key outreach tool for the dissemination of the geological information of the area and for the promotion of its geodiversity through a modern, sustainable, and environmentally aware tourism in an highly frequented protected area.

ABSTRACTThis paper presents the results of the 2021 and 2022 field activities carried out at San Nicola Island (Tremiti Islands, Southern Adriatic Sea) by two groups of students as part of the Environmental Geomorphology Field Mapping course held within the Master's Degree in Geological Sciences and Technologies of Earth and Planets at University ‘G. d'Annunzio’ of Chieti-Pescara. Field activities were carried out following an integrated approach that involved morphometric, geological, and geomorphological analyses, supported by the combination of traditional methods with modern survey instruments and techniques. The Main Map (1:2,500 scale) comprehensively depicts the landscape of San Nicola Island, which is affected by both long- and short-term evolutionary processes, as witnessed by widespread slope landforms. The cartographic products presented in this work can represent a useful tool in territorial planning and management, as well as a valuable base for further scientific studies.

Abstract The mother–infant relation is key to infant physical, cognitive and social development. Mutual regulation and cooperation are required to maintain the dyadic system, but the biological foundation of these responses remains to be clarified. In this study, we report the maternal calming responses to infant suckling during breastfeeding. Using behavioral measures and a Holter electrocardiogram as a readout of the maternal autonomic nervous system, the maternal activities during resting, sitting with her infant on her lap, and breastfeeding were assessed. We found that during breastfeeding, mothers talked less and maternal heart rate was lower than during sitting with the infant without breastfeeding. Congruently, maternal heart rate variability measurements indicated a higher parasympathetic activity during breastfeeding. Time-locked analyses suggested that this maternal calming response was initiated by the tactile stimulation at the breast by the infant face or mouth latch, which preceded the perceived milk ejection. These findings suggest that somatosensory stimuli of breastfeeding activate parasympathetic activity in mothers. Just as how the infant Transport Response facilitates the carrying of infants, the maternal calming responses during breastfeeding may promote efficient milk intake by inhibiting spontaneous maternal activities.

The essay analyses the characterisation of power in Christoph Ransmayr’s novel Cox oder Der Lauf der Zeit. Specifically, power is analysed on its political level, with the social implications that it necessarily entails on both the human and personal level, showing the individual in charge locked in the solitude of his distance from others; and on its gender level, which is expressed in the novel by the subjugation of the female to the male. In conclusion, nature and time in the novel are highlighted in their function as obstacles to limitless power.

Questionable research practises (QRPs) have been the focus of the scientific community amid greater scrutiny and evidence highlighting issues with replicability across many fields of science. To capture the most impactful publications and the main thematic domains in the literature on QRPs, this study uses a document co-citation analysis. The analysis was conducted on a sample of 341 documents that covered the past 50 years of research in QRPs. Nine major thematic clusters emerged. Statistical reporting and statistical power emerged as key areas of research, where systemic-level factors in how research is conducted are consistently raised as the precipitating factors for QRPs. There is also an encouraging shift in the focus of research into open science practises designed to address engagement in QRPs. Such a shift is indicative of the growing momentum of the open science movement, and more research can be conducted on how these practises are employed on the ground and how their uptake by researchers can be further promoted. However, the results suggest that, while pre-registration and registered reports receive the most research interest, less attention has been paid to other open science practises (e.g. data sharing).

IntroductionPeople represent the world in terms of two constructs: how something appears on the surface (appearance) and what it is underneath that surface (reality). Both constructs are central to various bodies of literature. What has not been done, however, is a systematic look at this collection of literature for overarching themes. Motivated by this research gap, the present scientometric review aimed to identify the common themes that penetrate through a century of scholarly work on appearance and reality. In doing so, this review also sketched a scientometric outline of the international network, pinpointing where the work was carried out.MethodsWith CiteSpace software, we computed an optimized document co-citation analysis with a sample of 4,771 documents (1929–2022), resulting in a network of 1,785 nodes.Results and discussionWe identified impactful publications, summarized major intellectual movements, and identified five thematic clusters (“Perception of Counseling Services”, “Appearance and Reality in Sociocultural Evolution,” “Cultural Heritage and Identity,” “Media and Culture,” and “Cultural Identity”), all with theoretical and pragmatic implications which we discuss. A deeper look at these clusters reveals new empirical questions and promising directions for future research.

Abstract Background Need for cognition (NFC) represents interindividual differences in tendencies to engage and enjoy cognitive endeavors. Exploratory information seeking (EIS) refers to individual tendencies to attain cognitive stimulation through acquiring information related to consumer products or services out of curiosity. Methods The current study aims to provide an in‐depth investigation of the relationship between NFC and EIS and extend this relation to determine neuroanatomical correlates of NFC and EIS. This study proposed two central hypotheses: (1) NFC and EIS scores are positively correlated and (2) the gray matter volume (GMV) of brain regions implicated in motivation, valuation, and reward systems are positively associated with both NFC and EIS. Self‐report and structural MRI data of 91 Singaporean Chinese participants were utilized for the study. Results No statistically significant correlation was revealed between NFC and EIS scores. Neuroanatomical associations of the GMV of brain regions implicated in visuospatial, attentional, and reward processing with individual constructs of interest were explored. When examining NFC and EIS scores, larger GMV in the right pallidum and left fusiform gyrus was found in participants that reported higher levels of NFC (vs. lower NFC levels), larger GMV in the left precuneus in those with greater tendencies to engage in EIS (vs. lower EIS levels), and larger GMV of the left fusiform gyrus associated with greater endorsement of both NFC and EIS. When investigating the exploratory factor analysis–generated factors of NFC and EIS, similar patterns of associations were found between self‐reported levels of agreement against factors and GMV of brain regions implicated. Conclusions Correlational analysis and exploratory factor analysis indicated the absence of a relationship between NFC and EIS. Additionally, voxel‐based morphometry whole‐brain analysis revealed neuroanatomical correlates of the GMV of brain regions implicated in visuospatial, attentional, and reward processing with NFC and EIS.

Measurement(s) Blood Oxygen Level-Dependent Response Technology Type(s) Functional Near-Infrared Spectroscopy Factor Type(s) Parenting Stress • Parental Bonding • Attachment Style Sample Characteristic - Organism Homo sapiens Sample Characteristic - Location Singapore

Abstract Specific facial features in infants automatically elicit attention, affection, and nurturing behaviour of adults, known as the baby schema effect. There is also an innate tendency to categorize people into in-group and out-group members based on salient features such as ethnicity. Societies are becoming increasingly multi-cultural and multi-ethnic, and there are limited investigations into the underlying neural mechanism of the baby schema effect in a multi-ethnic context. Functional magnetic resonance imaging (fMRI) was used to examine parents’ (N = 27) neural responses to (a) non-own ethnic in-group and out-group infants, (b) non-own in-group and own infants, and (c) non-own out-group and own infants. Parents showed similar brain activations, regardless of ethnicity and kinship, in regions associated with attention, reward processing, empathy, memory, goal-directed action planning, and social cognition. The same regions were activated to a higher degree when viewing the parents’ own infant. These findings contribute further understanding to the dynamics of baby schema effect in an increasingly interconnected social world.

System-justifying ideologies are a cluster of ideals that perpetuate a hierarchical social system despite being fraught with inequalities. Right-wing authoritarianism (RWA) and social dominance orientation (SDO) are two ideologies that have received much attention in the literature separately and together. Given that these ideologies are considered to be stable individual differences that are likely to have an evolutionary basis, there has yet to be any examination for volumetric brain structures associated with these variables. Here, we proposed an investigation of overlapping and non-overlapping brain regions associated with RWA and SDO in a sample recruited in Singapore. Indeed, it will be interesting to determine how RWA and SDO correlate in a country that proactively promotes institutionalized multi-culturalism such as Singapore. RWA and SDO scores were collected via self-report measures from healthy individuals (39 males and 43 females; age 25.89 ± 5.68 years). Consequently, voxel-based morphometry (VBM) whole brain and region of interest (ROI) analyses were employed to identify neuroanatomical correlates of these system-justifying ideologies. RWA and SDO scores were strongly correlated despite the low ideological contrast in Singapore's sociopolitical context. The whole brain analysis did not reveal any significant clusters associated with either RWA or SDO. The ROI analyses revealed clusters in the bilateral amygdala and ventromedial prefrontal cortex (vmPFC) that were associated with both RWA and SDO scores, whereas two clusters in the left anterior insula were negatively associated with only SDO scores. The study corroborates the claim of RWA and SDO as stable individual differences with identifiable neuroanatomical correlates, but our exploratory analysis suggests evidence that precludes any definitive conclusion based on the present evidence.

The unprecedented proliferation of novel psychoactive substances (NPS) in the illicit drug market has been a public health concern since their emergence in the 2000s. Their consumption can pose severe health risks as their mechanism of action is poorly understood and their level of toxicity is high mainly due to the diffusion of very potent synthetic cannabinoid receptor agonists and synthetic opioids. This study systemically analyses the evolution of the scientific literature on NPS to gain a better understanding of the areas of major research interests and how they interlink. Findings indicate that the published evidence covers clusters focused on classes of NPS that have received widespread media attention, such as mephedrone and fentanyl, and have largely been concerned with the pharmacological and the toxicological profiles of these substances. This scientometric perspective also provides greater insight into the knowledge gaps within this new and rapidly growing field of study and highlights the need for an interdisciplinary approach in tackling the NPS epidemic.

Corpus Atrophic Gastritis (CAG) is characterised by iron malabsorption leading to iron deficiency anaemia (IDA), which rarely responds to oral therapy. Ferric carboxymaltose (FCM), shown to be a safe and effective intravenous iron therapy in other diseases, has not been investigated yet in CAG. Thus, we aimed to assess the safety and efficacy of FCM in CAG-related IDA. A retrospective study on 91 patients identified CAG as the only cause of IDA treated with FCM. Twenty-three were excluded for incomplete follow-up. Sixty-eight were evaluated for safety and efficacy, while three were evaluated for safety only due to infusion interruption for side effects. Haemoglobin and iron storage were evaluated pre-infusion (T0), at 4 weeks (T4) and 12 weeks (T12) after infusion. An eventual IDA relapse was analysed. Two cases reported mild side effects. Haemoglobin significantly increased at T4, and T12, reaching +3.1 g/dL. Ferritin increased at T4, decreasing at T12, while transferrin saturation increased progressively until reaching a plateau. IDA relapsed in 55.4% of patients at a mean of 24.6 months. The only factor associated with relapse was female gender [OR (95% CI): 6.6 (1.5–28.6)]. FCM proved to be safe and effective in treating CAG-related IDA, ensuring quick and long-lasting recovery.

Symmetry has long been viewed as a feature of objects that facilitates ease of perception. Three experiments investigated 4- to 5-month-old infants’ detection and processing of vertical symmetry, oblique symmetry, and asymmetry in novel patterns and faces. In Experiment 1, infants showed the fewest shifts in visual fixations to vertical symmetry in patterns and faces, supporting the view that vertical symmetry is processed more efficiently than oblique symmetry or asymmetry. In Experiment 2, stimulus presentation disallowed more than a single visual fixation, and infants looked longer at a face that is vertically symmetrical compared to obliquely symmetrical or asymmetrical, and they looked equally to patterns regardless of symmetry. In Experiment 3, where pattern exposures were prolonged and inverted faces viewed, infants discriminated vertical symmetry in patterns but lost the advantage with vertical symmetry in faces. Thus, symmetry in patterns requires more processing time from infants, and inverting the face costs infants the normal perceptual advantage of symmetry, even though components of the face remain symmetrical. These findings suggest that infants are prepared to exploit symmetry in their everyday perceptual worlds.

Despite a rise in the use of functional Near Infra-Red Spectroscopy (fNIRS) to study neural systems, fNIRS signal processing is not standardized and is highly affected by empirical and manual procedures. At the beginning of any signal processing procedure, Signal Quality Control (SQC) is critical to prevent errors and unreliable results. In fNIRS analysis, SQC currently relies on applying empirical thresholds to handcrafted Signal Quality Indicators (SQIs). In this study, we use a dataset of fNIRS signals (N = 1,340) recorded from 67 subjects, and manually label the signal quality of a subset of segments (N = 548) to investigate the pitfalls of current practices while exploring the opportunities provided by Deep Learning approaches. We show that SQIs statistically discriminate signals with bad quality, but the identification by means of empirical thresholds lacks sensitivity. Alternatively to manual thresholding, conventional machine learning models based on the SQIs have been proven more accurate, with end-to-end approaches, based on Convolutional Neural Networks, capable of further improving the performance. The proposed approach, based on machine learning, represents a more objective SQC for fNIRS and moves towards the use of fully automated and standardized procedures.

Novel psychoactive substances (NPS) is an umbrella term used to describe a heterogeneous group of compounds that mimic the effects of existing drugs and whose demand and use rapidly emerge, change, or even vanish in the drug market. The novelty of this global phenomenon and its dynamic nature represent major challenges for the scientific community that constantly requires timely evidence-based inputs. Our aim is to review the literature on NPS and compare its temporal evolution according to the topics presented at the International Conference series on NPS over the past decade. Our analysis shows that some new clusters of research recently emerged in comparison to a previous review and that the material presented at the NPS Conferences anticipates the scientific literature by approximately 2.5 years. Such findings not only provide new original insights on the latest NPS trends but also address existing knowledge gaps in the NPS field, while emphasizing the importance of face-to-face thematic events supported by faster publication processes to inform prompt interventions and policy making.

Digital collaborative storytelling can be supported by an online learning-management system like Moodle, encouraging prosocial behaviors and shared representations. This study investigated children’s storytelling and collaborative behaviors during an online storytelling activity throughout the 2020 SARS-CoV-2 home confinement in Spain. From 1st to 5th grade of primary school, one-hundred-sixteen students conducted weekly activities of online storytelling as an extracurricular project of a school in Madrid. Facilitators registered participants’ platform use and collaboration. Stories were audio-recorded, transcribed verbatim, and analyzed using the Bears Family Story Analysis System. Three categories related to the SARS-CoV-2 pandemic were added to the story content analysis. The results indicate that primary students worked collaboratively in an online environment, with some methodology adaptations to 1st and 2nd grade. Story lengths tended to be reduced with age, while cohesion and story structure showed stable values in all grades. All stories were balanced in positive and negative contents, especially in characters’ behavior and relationships, while story problems remained at positive solution levels. In addition, the pandemic theme emerged directly or indirectly in only 15% of the stories. The findings indicate the potential of the online collaborative storytelling activities as a distance-education tool in promoting collaboration and social interactions.

Neural underpinnings of addiction have been widely investigated using traditional neuroimaging techniques and paradigms. However, certain mechanisms are still underexplored, and existing studies often do not adopt an ecological assessment. Functional near-infrared spectroscopy (fNIRS) emerges as a potential elective tool to assess real-time neural activity with high ecological validity, as well as a good spatial and temporal resolution. So far, fNIRS has been rarely used as an instrument to study the neural underpinnings of substance and behavioral dependence. Starting from the available scientific literature, we aim to present the various applications of fNIRS in the research field of addiction, leading to unprecedented advancements in research and clinical practice.

To curb the diffusion of the novel coronavirus (SARS-CoV-2), governments worldwide have introduced different policies, including lockdowns, social distancing, and mandatory mask wearing. Face mask wearing, especially, has an impact on the formation of first impressions, given that when meeting someone for the first time, individuals rely on the only available piece of information, the newly met person’s aesthetic appearance, in order to make initial estimations of other traits, such as competence, intelligence, or trustworthiness. However, face mask wearing affects the aesthetic appearance of an individual, creating uncertainty which, in turn, has been reported to reduce others’ perceived trustworthiness. In this paper, the influence of face mask wearing on strangers’ perceived trustworthiness and aesthetic appearance is assessed to verify the impact of this policy on impression formation. Participants (N = 71) have been instructed to assess the trustworthiness and the aesthetic appearance of a selection of 96 images depicting individuals of different ages (children, adults, and older adults), gender (men and women), and ethnicity (Asians or Caucasians). Participants were randomly divided into two groups: an experimental group and a control group. Participants in the experimental group (N = 38) rated faces of individuals wearing a face mask, while participants in the control group rated the same faces but in the absence of a face mask. Images were presented in random order. For each face, participants were asked to rate the aesthetic appearance and perceived trustworthiness of the stranger on two different 100-point Likert scales. Results demonstrate that (i) the correlation between perceived trustworthiness and aesthetic appearance is not affected by the presence of a face mask, and (ii) age, but not ethnicity and gender, influences the magnitude of differences in perceived trustworthiness levels during mask wearing.

Few habilitation strategies for children with autism spectrum disorder (ASD) consider their sleep-related problems. Together with the fact that caregivers of children with ASD also face issues with sleep, there may be yet-to-be uncovered relationships between caregiver-child sleep patterns and sleep quality, offering a key opportunity for clinicians to consider the needs of both child and caregiver in terms of sleep. 29 dyads of mothers and their children with ASD were recruited for this cohort study and both subjective (self-report questionnaires and sleep diaries) and objective (cortisol samples and actigraphy) measures of sleep were collected to investigate significant predictors of sleep quality. Comparative, correlational, and hierarchical analyses were conducted. Findings indicated that both mother and child experience sleep deprivation in terms of shorter sleep duration and poor sleep quality in terms of longer sleep onset latencies and a higher frequency of wake bouts. Exploratory hierarchical analyses also found that child-related sleep difficulties such as sleep disordered breathing and night waking significantly predict mothers’ sleep quality, which may point to the bi-directional influence of mother-child sleep. Based on these findings, it is recommended that clinicians adopt a family systems perspective and consider the sleep environment of the household, particularly that of the caregiver and child, when designing interventions for sleep-related problems in ASD. Finally, there is a need for additional support to promote good quality sleep among caregivers of children with ASD to bolster out-of-clinic care.

Social Media Disorder (SMD) is characterised by the intense and excessive use of social media. Although previous studies have shown that SMD was associated with poor mental health, research across types of usage and platforms remain limited. Here, we conducted an initial investigation of social media usage across platforms and its relation to anxiety, sleep and loneliness in female adolescents. Forty one 16- to 19-year-old British female adolescents were administered online questionnaires. Intensity of social media activity across Facebook, Instagram, Snapchat and Twitter was measured with the Social Media Disorder Scale. Anxiety was indicated by the Beck Anxiety Inventory Trait, loneliness was examined via a short three-point questionnaire and sleep quality was measured via both the Pittsburgh Sleep Quality Index and self-reported seven-day sleep diaries. Results showed that, compared to those without SMD, users with SMD experienced elevated levels of loneliness and had less sleep on average, and during the weekdays in particular. Only frequency of posting on Facebook, but not general usage, was associated with poorer sleep quality. These preliminary findings showed that social media disorder across platforms and usage could potentially have different associations to mental health and sleep.

The current study examines stability, continuity, and group and gender differences in the home environments of infants of mothers with early, remitted clinical depression and no postpartum depression, overcoming methodological variations in the extant literature. Fifty-five mothers diagnosed with clinical depression (major or minor depression, dysthymia, or depressive disorder not otherwise specified) at 5 months and fully remitted by 15 and 24 months, and 132 mothers with no postpartum depression (Mage = 32.47; 69.7% European American) completed the Home Observation for Measurement of the Environment (HOME) Inventory Infant/Toddler version when their infants were 15 and 24 months old. No differences in stability estimates of the HOME scales were found between the groups. In terms of continuity, controlling for maternal education and infant birth order, HOME responsivity, involvement, and total score decreased, while HOME acceptance increased between 15 and 24 months in the full sample. There were no effects of group or gender. Results may point to the home environment as a key protective factor for infants of mothers with early, remitted clinical depression, or findings may suggest improved maternal parenting cognitions and practices following remission.

In this article, we explore the concept of coregulation, which encompasses the mutual adaptation between partners in response to one another’s biology and behavior. Coregulation operates at both biological (hormonal and nervous system) and behavioral (affective and cognitive) levels and plays a crucial role in the development of self-regulation. Coregulation extends beyond the actions of individuals in a dyad and involves interactive contributions of both partners. We use as an example parent–child coregulation, which is pervasive and expected, as it emerges from shared genetic relatedness, cohabitation, continuous interaction, and the influence of common factors like culture, which facilitate interpersonal coregulation. We also highlight the emerging field of neural attunement, which investigates the coordination of brain-based neural activities between individuals, particularly in social interactions. Understanding the mechanisms and significance of neural attunement adds a new dimension to our understanding of coregulation and its implications for parent–child relationships and child development.

Gender differences and microbiota are gaining increasing attention. This study aimed to assess gender differences in gastric bacterial microbiota between subjects with healthy stomachs and those with autoimmune atrophic gastritis. This was a post hoc analysis of 52 subjects undergoing gastroscopy for dyspepsia (57.7% healthy stomach, 42.3% autoimmune atrophic gastritis). Gastric biopsies were obtained for histopathology and genomic DNA extraction. Gastric microbiota were assessed by sequencing the hypervariable regions of the 16SrRNA gene. The bacterial profile at the phylum level was reported as being in relative abundance expressed as 16SrRNA OTUs (>0.5%) and biodiversity calculated as Shannon-diversity index-H. All data were stratified for the female and male gender. Results showed that women with healthy stomachs had a higher gastric bacterial abundance and less microbial diversity compared to men. Likely due to hypochlorhydria and the non-acid intragastric environment, autoimmune atrophic gastritis seems to reset gender differences in gastric bacterial abundance and reduce biodiversity in males, showing a greater extent of dysbiosis in terms of reduced biodiversity in men. Differences between gender on taxa frequency at the phylum and genus level in healthy subjects and autoimmune atrophic gastritis were observed. The impact of these findings on the gender-specific natural history of autoimmune atrophic gastritis remains to be elucidated; in any case, gender differences should deserve attention in gastric microbiota studies.

Sleep and diet are essential for maintaining physical and mental health. These two factors are closely intertwined and affect each other in both timing and quality. Eating disorders, including anorexia nervosa and bulimia nervosa, are often accompanied by different sleep problems. In modern society, an increasing number of studies are being conducted on the relationship between eating disorders and sleep. To gain a more comprehensive understanding of this field and highlight influential papers as well as the main research domains in this area, a scientometric approach was used to review 727 publications from 1971 to 2023. All documents were retrieved from Scopus through the following string “TITLE-ABS ((“sleep” OR “insomnia”) AND (“anorexia nervosa” OR “bulimia nervosa” OR “binge eating” OR “eating disorder*”) AND NOT “obes*”) AND (LIMIT-TO (LANGUAGE, “English”))”. A document co-citation analysis was applied to map the relationship between relevant articles and their cited references as well as the gaps in the literature. Nine publications on sleep and eating disorders were frequently cited, with an article by Vetrugno and colleagues on nocturnal eating being the most impactful in the network. The results also indicated a total of seven major thematic research clusters. The qualitative inspection of clusters strongly highlights the reciprocal influence of disordered eating and sleeping patterns. Researchers have modelled this reciprocal influence by taking into account the role played by pharmacological (e.g., zolpidem, topiramate), hormonal (e.g., ghrelin), and psychological (e.g., anxiety, depression) factors, pharmacological triggers, and treatments for eating disorders and sleep problems. The use of scientometric perspectives provides valuable insights into the field related to sleep and eating disorders, which can guide future research directions and foster a more comprehensive understanding of this important area.

Infant cry is an adaptive signal of distress that elicits timely and mostly appropriate caring behaviors. Caregivers are typically able to decode the meaning of the cry and respond appropriately, but maladaptive caregiver responses are common and, in the worst cases, can lead to harmful events. To tackle the importance of studying cry patterns and caregivers’ responses, this review aims to identify key documents and thematic trends in the literature as well as existing research gaps. To do so, we conducted a scientometric review of 723 documents downloaded from Scopus and performed a document co-citation analysis. The most impactful publication was authored by Barr in 1990, which describes typical developmental patterns of infant cry. Six major research thematic clusters emerged from the analysis of the literature. Clusters were renamed “Neonatal Pain Analyzer” (average year of publication = 2002), “Abusive Head Trauma” (average year of publication = 2007), “Oxytocin” (average year of publication = 2009), “Antecedents of Maternal Sensitivity” (average year of publication = 2010), “Neurobiology of Parental Responses” (average year of publication = 2011), and “Hormonal Changes & Cry Responsiveness” (average year of publication = 2016). Research clusters are discussed on the basis of a qualitative inspection of the manuscripts. Current trends in research focus on the neurobiology of caregiver responses and the identification of factors promoting maternal sensitivity. Recent studies have also developed evidence-based strategies for calming crying babies and preventing caregivers’ maladaptive responses. From the clusters, two topics conspicuously call for future research: fathers’ responsiveness to infant cry and the impact of caregiver relationship quality on cry responsiveness.

IntroductionProton pump inhibitors (PPIs) have been widely prescribed as a primary treatment for acid-related disorders. A large body of literature reported several adverse outcomes due to PPI therapy, including an increased risk of gastric cancer (GC). Autoimmune atrophic gastritis (AAG) is a chronic inflammatory disorder affecting the oxyntic mucosa, leading to mucosal atrophy, intestinal metaplasia, and reduced gastric acid secretion, up to the possible development of dysplasia and intestinal-type GC. Whether PPI use may increase the GC risk in AAG patients has not yet been investigated. We conducted a case–control study in AAG patients to assess the association between the PPI use before AAG diagnosis and the development of GC at follow-up (FU).Materials and MethodsPatients were included from a prospective cohort of AAG patients (diagnosed 1992–2021) in a referral center for gastric autoimmunity; all patients adhered to an endoscopic–histological FU program according to Management of precancerous conditions and lesions in the stomach (MAPS) I/II (management of epithelial precancerous conditions) guidelines. At diagnosis, clinical/biochemical data and PPI use before AAG diagnosis (withdrawn at the time of diagnosis), for at least 12 months, were evaluated. Patients who developed gastric neoplastic lesions (GNLs) at FU were considered as cases; patients without a diagnosis of GNLs at FU were considered as controls. At a total FU of 2.3 years (1–13), 35 cases were identified, and controls were matched 2:1 by age ( ± 3 years), gender, and years of FU (n=70); therefore, a total of n=105 patients were included in the study.ResultsThe proportion of PPI users before AAG diagnosis was significantly higher in cases than in controls (54.3% vs. 18.6%, p

Human faces capture attention, provide information about group belonging, and elicit automatic prepared responses. Early experiences with other-race faces play a critical role in acquiring face expertise, but the exact mechanism through which early experience exerts its influence is still to be elucidated. Genetic factors and a multi-ethnic context are likely involved, but their specific influences have not been explored. This study investigated how oxytocin receptor gene (OXTR) genotypes and childcare experience interacted to regulate face categorization in adults. Information about single nucleotide polymorphisms of OXTR (rs53576) and experiences with own- and other-race child caregivers was collected from 89 Singaporean adults, who completed a visual categorization task with own- versus other-race faces. Participants were grouped into A/A homozygotes and G carriers and assigned a score to account for their type of child caregiver experience. A multivariate linear regression model was used to estimate the effect of genetic group, child caregiver experience, and their interaction on categorization reaction time. A significant interaction of genetic group and child caregiver experience (t = 2.48, p = 0.015), as well as main effects of both genetic group (t = −2.17, p = 0.033) and child caregiver experience (t = −4.29, p

Mastery motivation predicts achievement, but intricacies amongst preschoolers are unclear. In keeping with the Specificity Principle, school-age, and adolescent research demonstrates the importance of considering the "setting conditions" in which mastery motivation is observed. Here, Singaporean 4-year-olds' (N = 63) mastery-motivation-related behaviour (MMRB) (e.g. signs of persistence, focus, and pleasure) in mathematical and non-mathematical activities were observed. Relations between numeracy and MMRB during a mathematical game (outcome relevant setting) were determined, controlling for MMRB in other activities (outcome irrelevant settings). Association between MMRB during the mathematical game and receptive language (outcome irrelevant setting) was also examined. Consistent with the Specificity Principle, MMRB during the mathematical game was (i) associated with numeracy, after controlling for MMRB in other activities and (ii) did not predict language. Enhancing preschoolers' experiences, especially when implemented in contexts related to areas targeted for improvement, may benefit outcomes. These skills acquired in early life can become important predictors of future ability.

Introduction: Since screening programs for gastric cancer are not applicable in Western countries, identification and follow-up of gastric precancerous lesions, such as extensive intestinal metaplasia (IM), are worthwhile to increase the diagnosis of cancer at an early stage. We investigated whether an optimal age threshold to detect extensive IM in a European country exists. Methods: This was a post hoc analysis of prospectively collected data in a nationwide study involving consecutive patients aged between 50 and 65 years who underwent an upper endoscopy with the standard 5 gastric biopsies. The presence of extensive (antral and gastric body) IM on gastric mucosa was considered. Results: Data found that the prevalence of extensive IM was distinctly higher in patients aged 60–65 years, with a 2.28-fold increased probability compared to younger patients. None of the other considered factors (sex, BMI, smoking habit, first-degree family history, and symptoms) emerged as an independent predictor of extensive IM in the stomach. Conclusion: When deciding for an occasional gastric cancer screening in Western populations, the choice of an age range of 60–65 years might be appropriate, allowing detection of a distinctly high prevalence of extensive IM deserving scheduled follow-up.

Eating disorders (EDs), including anorexia nervosa (AN), are severe psychological disorders that affect individuals’ eating behaviours and body perception. Previous research has shown that people with EDs often report poorer sleep. Some literature has suggested that it is mood dysregulation that mediates the link between EDs and sleep. However, the majority of previous studies only focused on females, while male ED patients have been overlooked. Therefore, the present study aimed to investigate the relationships between EDs, mood, and sleep among male ED patients. Using a mixture of actigraphy recordings and self-reported questionnaires, the current study analysed a total 33 adult male participants diagnosed with AN. The participants first wore an actigraphy device for seven continuous days, following which their ED severity and mood were assessed by the Eating Disorder Examination Questionnaire (EDE-Q) and Depression Anxiety Stress Scale (DASS), respectively. The descriptive actigraphy results suggested that, similar to females, males with AN also showed disturbed sleep, including insomnia, sleep fragmentation, low sleep efficiency, and increased napping sessions. However, when ED severity was correlated against actigraphy data and mood, no significant relationships were found between them. Thus, it was suggested that future studies may investigate discrete ED symptoms instead of global ED severity interacting with sleep and mood. Overall, this study represents an initial step in the investigation of EDs and sleep and mood dysregulation among an under-represented sample.

Recent migration and globalization trends have led to the emergence of ethnically, religiously, and linguistically diverse countries. Understanding the unfolding of social dynamics in multicultural contexts becomes a matter of common interest to promote national harmony and social cohesion among groups. The current functional magnetic resonance imaging (fMRI) study aimed to (i) explore the neural signature of the in-group bias in the multicultural context; and (ii) assess the relationship between the brain activity and people’s system-justifying ideologies. A sample of 43 (22 females) Chinese Singaporeans (M = 23.36; SD = 1.41) was recruited. All participants completed the Right Wing Authoritarianism Scale and Social Dominance Orientation Scale to assess their system-justifying ideologies. Subsequently, four types of visual stimuli were presented in an fMRI task: Chinese (in-group), Indian (typical out-group), Arabic (non-typical out-group), and Caucasian (non-typical out-group) faces. The right middle occipital gyrus and the right postcentral gyrus showed enhanced activity when participants were exposed to in-group (Chinese) rather than out-group (Arabic, Indian, and Caucasian) faces. Regions having a role in mentalization, empathetic resonance, and social cognition showed enhanced activity to Chinese (in-group) rather than Indian (typical out-group) faces. Similarly, regions typically involved in socioemotional and reward-related processing showed increased activation when participants were shown Chinese (in-group) rather than Arabic (non-typical out-group) faces. The neural activations in the right postcentral gyrus for in-group rather than out-group faces and in the right caudate in response to Chinese rather than Arabic faces were in a significant positive correlation with participants’ Right Wing Authoritarianism scores (p < 0.05). Furthermore, the activity in the right middle occipital gyrus for Chinese rather than out-group faces was in a significant negative correlation with participants’ Social Dominance Orientation scores (p < 0.05). Results are discussed by considering the typical role played by the activated brain regions in socioemotional processes as well as the role of familiarity to out-group faces.

Sexism is a widespread form of gender discrimination which includes remarks based on gender stereotypes. However, little is known about the neural basis underlying the experience of sexist-related comments and how perceptions of sexism are related to these neural processes. The present study investigated whether perceptions of sexism influence neural processing of receiving sexist-related comments. Participants (N = 67) read experimental vignettes describing scenarios of comments involving gender stereotypes while near-infrared spectroscopy recordings were made to measure the hemodynamic changes in the prefrontal cortex. Results found a significant correlation between participants’ perceptions of sexism and brain activation in a brain cluster including the right dorsolateral prefrontal cortex and inferior frontal gyrus. There was a significant gender difference where female participants showed a stronger negative correlation compared to male participants. Future research can expand on these initial findings by looking at subcortical structures involved in emotional processing and gender stereotype application as well as examining cultural differences in perceptions of gender stereotypes and sexism.

With wearable sensors, the acquisition of physiological signals has become affordable and feasible in everyday life. Specifically, Photoplethysmography (PPG), being a low-cost and highly portable technology, has attracted notable interest for measuring and diagnosing cardiac activity, one of the most important physiological and autonomic indicators. In addition to the technological development, several specific signal-processing algorithms have been designed to enable reliable detection of heartbeats and cope with the lower quality of the signals. In this study, we compare three heartbeat detection algorithms: Derivative-Based Detection (DBD), Recursive Combinatorial Optimization (RCO), and Multi-Scale Peak and Trough Detection (MSPTD). In particular, we considered signals from two datasets, namely, the PPG-DALIA dataset (N = 15) and the FANTASIA dataset (N = 20) which differ in terms of signal characteristics (sampling frequency and length) and type of acquisition devices (wearable and medical-grade). The comparison is performed both in terms of heartbeat detection performance and computational workload required to execute the algorithms. Finally, we explore the applicability of these algorithms on the cardiac component obtained from functional Near InfraRed Spectroscopy signals (fNIRS).The results indicate that, while the MSPTD algorithm achieves a higher F1 score in cases that involve body movements, such as cycling (MSPTD: Mean = 74.7, SD = 14.4; DBD: Mean = 54.4, SD = 21.0; DBD + RCO: Mean = 49.5, SD = 22.9) and walking up and down the stairs (MSPTD: Mean = 62.9, SD = 12.2; DBD: Mean = 50.5, SD = 11.9; DBD + RCO: Mean = 45.0, SD = 14.0), for all other activities the three algorithms perform similarly. In terms of computational complexity, the computation time of the MSPTD algorithm appears to grow exponentially with the signal sampling frequency, thus requiring longer computation times in the case of high-sampling frequency signals, where the usage of the DBD and RCO algorithms might be preferable. All three algorithms appear to be appropriate candidates for exploring the applicability of heartbeat detection on fNIRS data.

Objective: The aim of the current study was to examine the potential relationship between sleep patterns, cortisol levels, and anxiety profiles in adolescents with Williams Syndrome (WS) compared to typically developing adolescents. Method: Thirteen adolescents with WS and thirteen TD adolescents (age range 12–18 years) were recruited. Participants were provided with a “testing kit”, containing instructions for collecting data through a sleep diary, MotionWare actigraphy, the Childhood Sleep Habits Questionnaire (CSHQ), and the Spence Children’s Anxiety Scale, and a salivary cortisol collection kit. Results: Adolescents in the WS group did not show diurnal variation in salivary cortisol. Significantly higher scores were reported for two CSHQ subsections, night wakings and parasomnias, in the WS group. Regarding the actigraphy, only significantly longer sleep latency was observed in the WS group. In comparison to the TD group, the WS group had significantly higher anxiety. As expected, the TD group showed typical diurnal variation in cortisol, whereas the WS group showed a flattened cortisol profile throughout the day. Conclusions: From the developmental perspective, this study provides new data supporting the conclusion that sleep problems are not transient but continue to persist into adolescence in WS. Future studies ought to consider examining the role of cortisol and its interplay with anxiety levels and sleep problems across the lifespan in individuals with WS.

Nowadays, there are several human attachment measures, most in the form of questionnaires that assess adult attachment styles. This study investigates the use of Feeney, Noller, Hanrahan, Sperling and Berman’s five-factors Attachment Style Questionnaire (ASQ, 1994), based on Bartholomew’s four-factors model (1991), and Hazan and Shaver’s three-factors model (1987). Nevertheless, no robust study has explored the ASQ questionnaire in Spanish compared to other cultures, such as Italian and Japanese. Therefore, the linguistic translation of the Spanish version of the ASQ was performed, based on the back-translation methodology. The results indicate that 5-factors ASQ Spanish version explains 43.67% of the variance, similar to the original English-Australian ASQ version. The Italian and Japanese versions explain 49.37% and 52.27% of the variance, respectively. No age correlation for any ASQ factors in the Japanese sample was found; meanwhile, the Spanish and Italian cultures showed a positive correlation with age and “Confidence” and negative correlation with age and “Relationships as Secondary” ASQ factors. Some transcultural differences and possible research approaches are addressed.