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1. High-sensitivity analysis of clonal hematopoiesis reveals increased clonal complexity of potential-driver mutations in severe COVID-19 patients.

Author

Chiara Ronchini, Chiara Caprioli, Gianleo Tunzi, Francesco Furio D'Amico, Emanuela Colombo, Marco Giani, Giuseppe Foti, Donatella Conconi, Marialuisa Lavitrano, Rita Passerini, Luca Pase, Silvio Capizzi, Fabrizio Mastrilli, Myriam Alcalay, Roberto Orecchia, Gioacchino Natoli, and Pier Giuseppe Pelicci

Subjects
Medicine, Science
Abstract

Whether Clonal Hematopoiesis (CH) represents a risk factor for severity of the COVID-19 disease remains a controversial issue. We report the first high- sensitivity analysis of CH in COVID-19 patients (threshold of detection at 0.5% vs 1 or 2% in previous studies). We analyzed 24 patients admitted to ICU for COVID-19 (COV-ICU) and 19 controls, including healthy subjects and asymptomatic SARS-CoV2-positive individuals. Despite the significantly higher numbers of CH mutations identified (80% mutations with

Published
2024
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