Search

Your search keyword '"Gianfranco Ferraciolli"' showing total 3 results
Start Over Author "Gianfranco Ferraciolli"
3 results on '"Gianfranco Ferraciolli"'

1. Is treat-to-target really working in rheumatoid arthritis? a longitudinal analysis of a cohort of patients treated in daily practice (RA BIODAM)

Author

Joel Paschke, Sofia Ramiro, E. Hutchings, Cheryl Barnabe, Dirkjan van Schaardenburg, Thierry Schaeverbeke, Alexandre Sepriano, Désirée van der Heijde, Bernard Combe, Robert Landewé, Marina Backhaus, Maurizio Rossini, Margaret Larche, Joanne Homik, Marcello Govoni, Walter P. Maksymowych, Cornelia F Allaart, Ori Elkayam, Clifton O. Bingham, Alain Saraux, J. Carter Thorne, Oliver FitzGerald, Luigi Sinigaglia, Gilles Boire, Hilde Berner Hammer, R. Dadashova, Gianfranco Ferraciolli, Paul P. Tak, Maxime Dougados, Alain Cantagrel, Mikkel Østergaard, Clinical Immunology and Rheumatology, AII - Inflammatory diseases, Ramiro, Sofia [0000-0002-8899-9087], van der Heijde, Désirée [0000-0002-5781-158X], Sepriano, Alexandre [0000-0003-1954-0229], Boire, Gilles [0000-0003-2481-5821], Saraux, Alain [0000-0002-8454-7067], Rossini, Maurizio [0000-0001-9692-2293], Bingham, Clifton O [0000-0002-4752-5029], Tak, Paul P [0000-0002-3532-5409], Maksymowych, Walter P [0000-0002-1291-1755], Apollo - University of Cambridge Repository, Leiden University Medical Center (LUMC), Zuyderland Hospital [Heerlen, The Netherlands], Amsterdam Rheumatology & Immunology Center - ARC [Amsterdam, the Netherlands] (Amsterdam UMC), NOVA Medical School - Faculdade de Ciências Médicas (NMS), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), St Vincent's University Hospital, Copenhagen Center for Arthritis Research,Copenhagen (Center for Rheumatology and Spine Diseases), Rigshospitalet [Copenhagen], Copenhagen University Hospital, University of Alberta, Tel Aviv Sourasky Medical Center [Te Aviv], University of Toronto, McMaster University [Hamilton, Ontario], Università cattolica del Sacro Cuore [Roma] (Unicatt), Park-Klinik Weissensee, CIUSSS de l'Estrie - CHUS, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Aquitaine’s Care and Research organisation for inflammatory and Immune-Mediated diseases [CHU Bordeaux] (FHU ACRONIM), CHU Bordeaux [Bordeaux], CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Equipe 4 : ECaMO - Épidémiologie clinique appliquée aux maladies rhumatismales et musculo-squelettiques (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Verona (UNIVR), Azienda Ospedaliero-Universitaria Sant'Anna Hospital of Ferrara, Clinica Ortopedica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, parent, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, University of Calgary, Johns Hopkins University School of Medicine [Baltimore], Ghent University Hospital, Cambridge University Hospitals - NHS (CUH), University of Cambridge [UK] (CAM), Diakonhjemmet Hospital, and CaRE Arthritis Ltd

Subjects
Male, rheumatoid arthritis, MESH: Remission Induction, MESH: Antirheumatic Agents, treat-to-target, Patient Care Planning, Arthritis, Rheumatoid, Cohort Studies, remission, 0302 clinical medicine, Daily practice, Rheumatoid, Immunology and Allergy, Medicine, 030212 general & internal medicine, Longitudinal Studies, MESH: Longitudinal Studies, MESH: Cohort Studies, MESH: Aged, MESH: Arthritis, Rheumatoid, MESH: Middle Aged, MESH: Clinical Decision-Making, Remission Induction, Middle Aged, 3. Good health, Clinical Practice, C-Reactive Protein, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Rheumatoid arthritis, Antirheumatic Agents, Cohort, Joint damage, MESH: Tumor Necrosis Factor Inhibitors, Female, Adult, medicine.medical_specialty, MESH: Rheumatoid Factor, Immunology, Clinical Decision-Making, Blood Sedimentation, General Biochemistry, Genetics and Molecular Biology, NO, Disease activity, 03 medical and health sciences, Rheumatology, Rheumatoid Factor, Internal medicine, MESH: Patient Care Planning, MESH: C-Reactive Protein, Humans, In patient, MESH: Blood Sedimentation, Aged, 030203 arthritis & rheumatology, MESH: Humans, business.industry, Tumor Necrosis Factor Inhibitors, Arthritis, MESH: Adult, Treat to target, medicine.disease, MESH: Male, business, MESH: Female
Abstract

ObjectivesTo investigate whether following a treat-to-target (T2T)-strategy in daily clinical practice leads to more patients with rheumatoid arthritis (RA) meeting the remission target.MethodsRA patients from 10 countries starting/changing conventional synthetic or biological disease-modifying anti-rheumatic drugs were assessed for disease activity every 3 months for 2 years (RA BIODAM (BIOmarkers of joint DAMage) cohort). Per visit was decided whether a patient was treated according to a T2T-strategy with 44-joint disease activity score (DAS44) remission (DAS44 ResultsIn total 4356 visits of 571 patients (mean (SD) age: 56 (13) years, 78% female) were included. Appropriate application of T2T was found in 59% of the visits. T2T (vs no T2T) did not yield a higher likelihood of DAS44 remission 3 months later (OR (95% CI): 1.03 (0.92 to 1.16)), but sustained T2T resulted in an increased likelihood of achieving DAS44 remission (OR: 1.19 (1.03 to 1.39)). Similar results were seen with DAS28-ESR remission. For more stringent definitions (CDAI, SDAI and ACR/EULAR Boolean remission), T2T was consistently positively associated with remission (OR range: 1.16 to 1.29), and sustained T2T had a more pronounced effect on remission (OR range: 1.49 to 1.52).ConclusionIn daily clinical practice, the correct application of a T2T-strategy (especially sustained T2T) in patients with RA leads to higher rates of remission.

Published
2020

2. Serum IL-33, a new marker predicting response to rituximab in rheumatoid arthritis

Author

Martin Soubrier, Houria Hendel Chavez, Elodie Rivière, Barbara Tolusso, Bineta Ly, Maxime Dougados, Alice Courties, Paul-Olivier Rouzaire, Edward M Vital, Gianfranco Ferraciolli, Yassine Taoufik, Xavier Mariette, Jérémie Sellam, Paul Emery, Centre de Recherche Saint-Antoine (UMRS893), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de rhumatologie [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Immunologie des Maladies Virales et Autoimmunes (IMVA - U1184), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Clermont-Ferrand, Rheumatology Department, Catholic University of the Sacred Heart, University of Leeds, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Rhumatologie [CHU Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, This work was supported by Roche France, who sponsored the study but were not involved in the interpretation of the data or in the preparation of the manuscript., Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche Saint-Antoine (CR Saint-Antoine), Service de rhumatologie, inflammation-immunopathologie- biothérapie [CHU Saint-Antoine] (DHU i2B ), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Saint-Antoine [APHP], Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Bicêtre, Centre de Recherche Saint-Antoine ( CR Saint-Antoine ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de rhumatologie, inflammation-immunopathologie- biothérapie [CHU Saint-Antoine] ( DHU i2B ), CHU Saint-Antoine [APHP]-Assistance publique - Hôpitaux de Paris (AP-HP), Immunologie des Maladies Virales et Autoimmunes ( IMVA - U1184 ), Université Paris-Sud - Paris 11 ( UP11 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité ( CRESS (U1153 / UMR_A 1125) ), Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Bicêtre, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), CHU Saint-Antoine [APHP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
0301 basic medicine, medicine.medical_specialty, Population, [ SDV.IMM.IMM ] Life Sciences [q-bio]/Immunology/Immunotherapy, Gastroenterology, [ SDV.MHEP.RSOA ] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Rheumatoid factor, education, 030203 arthritis & rheumatology, education.field_of_study, business.industry, Odds ratio, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, medicine.disease, Rheumatology, 3. Good health, 030104 developmental biology, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Rheumatoid arthritis, Immunology, Cohort, Rituximab, business, Rheumatism, medicine.drug
Abstract

International audience; Background: Recent works have suggested a possible link between interleukin (IL)-33 and B-cell biology. We aimed to study the possible association between serum IL-33 detection and response to rituximab (RTX) in rheumatoid arthritis (RA) patients in different cohorts with an accurate enzyme-linked immunosorbent assay (ELISA).Methods: Serum IL-33, rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP), and high serum immunoglobulin (Ig)G levels were assessed in 111 RA patients receiving a first course of 2 g RTX (cohort 1) in an observational study and in 74 RA patients treated with the same schedule in routine care (cohort 2). Univariate and multivariate analyses identified factors associated with a European League Against Rheumatism (EULAR) response at 24 weeks.Results: At week 24, 84/111 (76%) and 54/74 (73%) patients reached EULAR response in cohorts 1 and 2, respectively. Serum IL-33 was detectable in only 33.5% of the patients. In the combined cohorts, the presence of RF or anti-CCP (odds ratio (OR) 3.27, 95% confidence interval (CI) 1.13–9.46; p = 0.03), high serum IgG (OR 2.32, 95% CI 1.01–5.33; p = 0.048), and detectable serum IL-33 (OR 2.40, 95% CI 1.01–5.72; p = 0.047) were all associated with RTX response in multivariate analysis. The combination of these three factors increased the likelihood of response to RTX. When serum IL-33 detection was added to seropositivity and serum IgG level, 100% of the patients with the three risk factors (corresponding to 9% of the population) responded to RTX (OR versus patients with none of the three risk factors 29.61, 95% CI 1.30–674.79; p = 0.034).Conclusion: Detectable serum IL-33 may predict clinical response to RTX independently of, and synergistically with, auto-antibodies and serum IgG level.

Published
2016

3. SAT0171 Serum IL-33 Independently Predicts Response To Rituximab in Rheumatoid Arthritis: Data from The Smart and Replication Cohorts

Author

Alice Courties, Jérémie Sellam, Martin Soubrier, Etienne Rivière, Maxime Dougados, P.-O. Rouzaire, Gianfranco Ferraciolli, Paul Emery, Barbara Tolusso, E.M. Vital, and Xavier Mariette

Subjects
medicine.medical_specialty, Multivariate analysis, biology, business.industry, Immunology, medicine.disease, Gastroenterology, General Biochemistry, Genetics and Molecular Biology, Interleukin 33, Rheumatology, Rheumatoid arthritis, Internal medicine, Cohort, medicine, biology.protein, Immunology and Allergy, Rheumatoid factor, Rituximab, Antibody, business, medicine.drug, Whole blood
Abstract

Background In a transcriptomic study, we found that whole blood interleukin-33 (IL-33) mRNA expression is increased in patients with rheumatoid arthritis (RA) responding to rituximab (RTX) (1). Using one ELISA IL-33 kit (DuoSet, R&D) for protein assessment, we previously reported an association between serum IL-33 level and RTX response in a single cohort, but additional experiments have recently raised caution about accuracy of this kit for sera measurements (2). Recommendations from the manufacturer advice to use for human sera another assay (Quantikine, R&D). Objectives To replicate in different cohorts and with a more accurate ELISA assay the possible association between detectable serum level of IL-33 and response to RTX in RA patients. Methods Serum IL-33 level and B-cell biomarkers known to be associated with RTX response (rheumatoid factor [RF], anti-citrullinated cyclic peptide [anti-CCP] antibodies, high serum IgG level above upper limit normal >12.7 g/L) were assessed in 111 RA patients receiving a first course of 2 grams RTX in the SMART cohort (85% of patients with RF or anti-CCP) as well as, for replication, in 74 RA patients (including 32 patients from Leeds, UK and 42 from Clermont-Ferrand, France) treated with the same schedule in routine care (97% of patients with RF or anti-CCP). We performed uni- and multivariate analyzes to identify factors associated with a EULAR response at 24 weeks. Results At week 24, 84 (76%) and 54 (73%) patients reached EULAR response in SMART and in replication cohort, respectively. Serum IL-33 was detectable in 27/111 (24%) and 35/74 (47%) patients from SMART and replication cohort, respectively. In SMART, multivariate analysis indicated that auto-antibodies status (positive RF or anti-CCP) were associated with RTX response (OR 3.47 95%CI 1.04–11.60; p=0.04). The same trend was observed for high serum IgG (OR 2.82 95%CI 0.97–8.14; p=0.056) but not for serum IL-33. In the replication cohort, detectable serum IL-33 was independently associated with RTX response (OR 3.73, 95%CI [1.12–12.38]; p=0.03) with the same trend for auto-antibodies status (OR 32, 95%CI [0.69–999]; p=0.08), but without significant result for high serum IgG. When we combined both cohorts (n=185), the 3 parameters were associated with RTX response in multivariate analysis: presence of RF or anti-CCP (OR 3.27 95%CI 1.13–9.46; p=0.03), high serum IgG (OR 2.32, 95%CI 1.01–5.33; p=0.048) and detectable IL-33 (OR 2.40 95%CI 1.01–5.72; p=0.047). There was synergy between the 3 predictive factors since detection of IL-33 in patients having positive auto-antibodies and high IgG level improved likelihood of response (100% EULAR responders) compared with patients having only positive auto-antibodies and high IgG level (77% responders) or compared with those without any of these factors (55% responders) (Figure 1). Conclusions Using an accurate ELISA kit, serum IL-33 may predict clinical response to RTX, independently of and synergistically with auto-antibodies and serum IgG level References Sellam J A Rheum 2014 Riviere E Ann Rheum Dis 2015 Disclosure of Interest None declared

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results