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172 results on '"Giallongo, C"'

1. MacroH2A1.1 as a crossroad between epigenetics, inflammation and metabolism of mesenchymal stromal cells in myelodysplastic syndromes

Author

Giallongo, C., Dulcamare, I., Giallongo, S., Duminuco, A., Pieragostino, D., Cufaro, M. C., Amorini, A. M., Lazzarino, G., Romano, A., Parrinello, N., Di Rosa, M., Broggi, G., Caltabiano, R., Caraglia, M., Scrima, M., Pasquale, L. S., Tathode, M. S., Li Volti, G., Motterlini, R., Di Raimondo, F., Tibullo, D., and Palumbo, G. A.

Published
2023
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3. P01 LACTATE TRAFFICKING INHIBITION RESTORES SENSITIVITY TO PROTEASOME INHIBITHORS AND ORCHESTRATES IMMUNOMICROENVIRONMENT IN MULTIPLE MYELOMA

Author

Giallongo, C., primary, Zuppelli, T., additional, Scandura, G., additional, La Spina, E., additional, Dulcamare, I., additional, Cambria, D., additional, Giallongo, S., additional, Romano, A., additional, Parrinello, N., additional, Del Fabro, V., additional, Aguennoz, M., additional, Li Volti, G., additional, Palumbo, G.A., additional, Di Raimondo, F., additional, and Tibullo, D., additional

Published
2023
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4. MACROH2A1.1 SITS AT THE INTERPLAY BETWEEN EPIGENETICS AND INFLAMMATION OF MESENCHYMAL STROMAL CELLS IN MYELODYSPLASTIC SYNDROMES

Author

Giallongo, C., primary, Dulcamare, I., additional, Giallongo, S., additional, Duminuco, A., additional, Pieragostino, D., additional, Cufaro, M.C., additional, Amorini, A.M., additional, Lazzarino, G., additional, Romano, A., additional, Parrinello, N., additional, Marino, S., additional, Di Rosa, M., additional, Broggi, G., additional, Caltabiano, R., additional, Li Volti, G., additional, Motterlini, R., additional, Di Raimondo, F., additional, Tibullo, D., additional, and Palumbo, G., additional

Published
2023
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5. P02 ARGININE DEPRIVATION INDUCES ACQUISITION OF A SENESCENT PHENOTYPE AND FAVORS GENOMIC INSTABILITY IN MULTIPLE MYELOMA PLASMACELLS

Author

Romano, A., primary, Scandura, G., additional, Giallongo, C., additional, La Spina, E., additional, Giallongo, S., additional, Longhitano, L., additional, Zuppelli, T., additional, Dulcamare, I., additional, Parrinello, N. L., additional, Polito, F., additional, Oteri, R., additional, Aguennouz, M., additional, Vicario, N., additional, Amorini, A. M., additional, Del Fabro, V., additional, Conticello, C., additional, Li Volti, G., additional, Palumbo, G. A., additional, Tibullo, D., additional, and Di Raimondo, F., additional

Published
2023
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6. P59 ACTIVE TREATMENT AND LOW IGM ARE ASSOCIATED WITH INFERIOR SARS-COV-2 SPIKE ANTIBODY RESPONSE TO THREE DOSES OF COVID-19 RNA VACCINATION IN PATIENTS WITH MULTIPLE MYELOMA

Author

Duminuco, A., primary, Romano, A., additional, Leotta, D., additional, La Spina, E., additional, Cambria, D., additional, Bulla, A., additional, Del Fabro, V., additional, Tibullo, D., additional, Giallongo, C., additional, Palumbo, G.A., additional, Conticello, C., additional, and Di Raimondo, F., additional

Published
2023
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9. P731: INTERPLAY BETWEEN INFLAMMATION AND EPIGENETICS IN TUMOR REPROGRAMMING OF MESENCHYMAL STROMAL CELLS (MSCS) IN MYELODYSPLASTIC SYNDROMES (MDS)

Author

Giallongo, C., primary, Dulcamare, I., additional, Tibullo, D., additional, Pieragostino, D., additional, Cufaro, M. C., additional, Amorini, M. A., additional, Lazzarino, G., additional, Romano, A., additional, Scandura, G., additional, Zuppelli, T., additional, Di Rosa, M., additional, Duminuco, A., additional, Broggi, G., additional, Caltabiano, R., additional, Floresti, R., additional, Motterlini, R., additional, Di Raimondo, F., additional, and Palumbo, G. A., additional

Published
2022
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11. P988: LACTATE RESHAPES TUMOR MICROENVIRONMENT AND METABOLIC PROFILE IN MYELOFIBROSIS

Author

Giallongo, S., primary, Tibullo, D., additional, Spampinato, M., additional, Giallongo, C., additional, La Spina, E., additional, Longhitano, L., additional, Romano, A., additional, Dulcamare, I., additional, Barbato, A., additional, Scandura, G., additional, Amorini, A. M., additional, Lazzarino, G., additional, Zuppelli, T., additional, Caltabiano, R., additional, Li Volti, G., additional, Di Raimondo, F., additional, and Palumbo, G. A. M., additional

Published
2022
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12. Hedgehog signaling pathways in multiple myeloma

Author

Dulcamare, I., primary, Giallongo, S., additional, Vicario, N., additional, Scandura, G., additional, Barbato, A., additional, La Spina, E., additional, Longhitano, L., additional, Cambria, D., additional, Tibullo, D., additional, Zuppelli, T., additional, Lo Furno, D., additional, Parenti, R., additional, Li Volti, G., additional, Palumbo, G.A., additional, Di Raimondo, F., additional, Romano, A., additional, and Giallongo, C., additional

Published
2022
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14. Electronic nicotine delivery systems exhibit reduced bronchial epithelial cells toxicity compared to cigarette: the Replica Project

Author

Caruso, M., Emma, R., Distefano, A., Rust, S., Poulas, K., Zadjali, F., Giordano, A., Volarevic, V., Mesiakaris, K., Al Tobi, M., Boffo, S., Arsenijevic, A., Zuccarello, P., Giallongo, C., Ferrante, M., Polosa, R., Li Volti, G., Pulvirenti, R., Carota, G., Spampinato, M. R., Caruso, T., Karanasios, G., Albalushi, N., Canciello, A., and Ilic, A.

Subjects
Aerosols, Cell biology, Nicotine, Volatile Organic Compounds, Multidisciplinary, Bronchi, Cell Survival, Cytokines, Electronic Nicotine Delivery Systems, Epithelial Cells, Humans, Inhibitory Concentration 50, Smoke, Tobacco, Tobacco Products, Science, Biological techniques, Biochemistry, Article, Risk factors, Medicine
Abstract

Electronic nicotine delivery systems (ENDS) may reduce health risks associated with chronic exposure to smoke and their potential benefits have been the matter of intense scientific debate. We aimed to replicate three published studies on cytotoxic and inflammatory effects of cigarette smoke and ENDS aerosol in an independent multi-center ring study. We aimed to establish the reliability of results and the robustness of conclusions by replicating the authors’ experimental protocols and further validating them with different techniques. Human bronchial epithelial cells (NCI-H292) were exposed to cigarette whole smoke and vapor phase and to aerosol from ENDS. We also assessed the inflammatory cytokines interleukin-6 and interleukin-8 and the remodeling mediator matrix metalloproteinase-1. We replicated cell viability results and confirmed that almost 80% of cytotoxic effects are due to volatile compounds in the vapor phase of smoke. Our findings substantiated the reduced cytotoxic effects of ENDS aerosol. However, our data on inflammatory and remodeling activity triggered by smoke differed significantly from those in the original reports. Taken together, independent data from multiple laboratories clearly demonstrated the reduced toxicity of ENDS products compared to cigarettes.

Published
2021

15. Mitochondrial functions, energy metabolism and protein glycosylation are interconnected processes mediating resistance to bortezomib in multiple myeloma cells

Author

Tibullo, D., Giallongo, C., Romano, A., Vicario, N., Barbato, A., Puglisi, F., Parenti, R., Amorini, A. M., Saab, M. W., Tavazzi, Barbara, Mangione, Renata, Brundo, M. V., Lazzarino, Giacomo, Palumbo, G. A., Volti, G. L., Di Raimondo, F., Lazzarino, G., Tavazzi B. (ORCID:0000-0001-8743-0895), Mangione R., Lazzarino G., Tibullo, D., Giallongo, C., Romano, A., Vicario, N., Barbato, A., Puglisi, F., Parenti, R., Amorini, A. M., Saab, M. W., Tavazzi, Barbara, Mangione, Renata, Brundo, M. V., Lazzarino, Giacomo, Palumbo, G. A., Volti, G. L., Di Raimondo, F., Lazzarino, G., Tavazzi B. (ORCID:0000-0001-8743-0895), Mangione R., and Lazzarino G.

Abstract

The proteasome inhibitor bortezomib (BTZ) has emerged as an effective drug for the treatment of multiple myeloma even though many patients relapse from BTZ therapy. The present study investigated the metabolic pathways underlying the acquisition of bortezomib resistance in multiple myeloma. We used two different clones of multiple myeloma cell lines exhibiting different sensitivities to BTZ (U266 and U266-R) and compared them in terms of metabolic profile, mitochondrial fitness and redox balance homeostasis capacity. Our results showed that the BTZ-resistant clone (U266-R) presented increased glycosylated UDP-derivatives when compared to BTZ-sensitive cells (U266), thus also suggesting higher activities of the hexosamine biosynthetic pathway (HBP), regulating not only protein O-and N-glycosylation but also mitochondrial functions. Notably, U266-R displayed increased mitochondrial biogenesis and mitochondrial dynamics associated with stronger antioxidant defenses. Furthermore, U266-R maintained a significantly higher concentration of substrates for protein glycosylation when compared to U266, particularly for UDP-GlcNac, thus further suggesting the importance of glycosylation in the BTZ pharmacological response. Moreover, BTZ-treated U266-R showed significantly higher ATP/ADP ratios and levels of ECP and also exhibited increased mitochondrial fitness and antioxidant response. In conclusions, our findings suggest that the HBP may play a major role in mitochondrial fitness, driving BTZ resistance in multiple myeloma and thus representing a possible target for new drug development for BTZ-resistant patients.

Published
2020

18. Biological properties of itraconazole-SLNs

Author

Fuochi, V., Carbone, C., Pignatello, R., Petronio Petronio, G., Avola, R., Puglisi, Giovanni, Tibullo, D., Giallongo, C., Puglisi, F., and Furneri, P. M.

Published
2018

19. PS1362 TRYPTOPHAN DEPRIVATION DUE TO INCREASED IDO-1 TRIGGERS A METABOLIC ADAPTIVE RESPONSE AND DOWN-REGULATES CD38 IN MULTIPLE MYELOMA

Author

Romano, A., primary, Puglisi, F., additional, Parrinello, N.L., additional, Giallongo, C., additional, La Cava, P., additional, Todoerti, K., additional, Tibullo, D., additional, Camiolo, G., additional, Del Fabro, V., additional, Cambria, D., additional, Conticello, C., additional, Palumbo, G.A., additional, Cenci, S., additional, Neri, A., additional, and Di Raimondo, F., additional

Published
2019
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20. PF658 THE NEUTROPHIL TO LYMPHOCYTE RATIO (NLR) IS A CHEAP SURROGATE OF EXPANSION OF MYELOID-DERIVED SUPPRESSOR CELLS IN MYELOFIBROSIS BEFORE AND AFTER TREATMENT WITH RUXOLITINIB: A SINGLE-CENTER EXPERIENCE

Author

Romano, A., primary, Parrinello, N.L., additional, Giallongo, C., additional, Puglisi, F., additional, Cambria, D., additional, Camiolo, G., additional, Tibullo, D., additional, Lambusta, E., additional, Raimondo, F. Di, additional, and Palumbo, G.A., additional

Published
2019
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21. PF585 GENE-EXPRESSION PROFILE OF HIGH-DENSITY NEUTROPHILS REVEALS PROGRESSIVE DIFFERENCES IN MGUS AND MULTIPLE MYELOMA, ASSOCIATED WITH REDUCED PHAGOCYTOSIS AND INCREASED INFECTION SUSCEPTIBILITY

Author

Romano, A., primary, Parrinello, N.L., additional, Simeon, V., additional, Bellofiore, C., additional, Giallongo, C., additional, Puglisi, F., additional, Cava, P. La, additional, Camiolo, G., additional, Brundo, M.V., additional, Silvia, S., additional, Tibullo, D., additional, Palumbo, G.A., additional, Conticello, C., additional, Musto, P., additional, and Raimondo, F. Di, additional

Published
2019
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33. Biological properties of Cakile maritima Scop. (Brassicaceae) extracts.

Author

FUOCHI, V., BARBAGALLO, I., DISTEFANO, A., PUGLISI, F., PALMERI, R., DI ROSA, M., GIALLONGO, C., LONGHITANO, L., FONTANA, P., SFERRAZZO, G., TIRALONGO, F., RACCUIA, S. A., RONSISVALLE, S., LI VOLTI, G., FURNERI, P. M., and TIBULLO, D.

Abstract

OBJECTIVE: Cakile maritima scop. (CKM) is a herbaceous plant (Brassicaceae) growing also in high salinity environment. It is an annual plant growing in clumps or mounds in the sand on beaches and bluffs. MATERIALS AND METHODS: Stems, seeds, leaves and flowers of CKM were used to obtain 70% of ethanol extracts. The phenolic content of the different extracts was evaluated by the Folin-Ciocalteu method. The separation of phytochemical compounds was based on ultra- performance liquid chromatography coupled to mass spectrometry. Radical scavenging activity was determined by 1,1-diphenyl-2-picrylhydrazyl assay. The qualitative assay for the inhibition of α-glucosidase was quantified spectrophotometrically and the anti-inflammatory activity was determined in the U937 cell line by using gene expression of pro-inflammatory cytokines. Cell viability assay was done in U937, MM1S, and U266 cells by using the 3-(4,5-Dimethyl- 2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay. The antimicrobial activity was investigated by MIC determination, "double- triple combinations assay", and growth inhibition curves analysis, using the extracts individually or in various combination. Statistical analysis was performed by the Student's t-test and ANOVA. RESULTS: All parts of the plant exhibited a high antioxidant capacity as measured by DPPH assay. Furthermore, all extracts reduced (about 10 folds) the expression of inflammatory cytokines in macrophage following LPS treatment. As regards the antibacterial activity, only the seeds extract was able to inhibit both Gram-negative and Gram-positive bacteria when tested alone, whereas dual combinations of different extracts (leaves, flowers, stems and seeds) caused bacterial inhibition exhibiting a synergic action. Finally, we showed that the extracts did not exhibit cytotoxic effects in normal cells and that, surprisingly, it exhibited an anti-proliferative effect (inhibition ≈80%) in multiple myeloma U266 cells. CONCLUSIONS: Our study suggests that CKM possesses antioxidant, anti-inflammatory, antibacterial, anti-proliferative activities and such pleiotropic effects may be exploited under various pathological conditions. [ABSTRACT FROM AUTHOR]

Published
2019

42. THE ROLE OF SPARC IN CHRONIC MYELOID LEUKEMIA

Author

Giallongo, C., La Cava, P., Tibullo, P., Ignazio Barbagallo, ALESSANDRA ROMANO, Del Fabro, V., Stagno, F., Chiarenza, A., Spina, P., Branca, A., Stefania Stella, Paolo VIGNERI, Palumbo, Giuseppe Alberto Maria, and Francesco Di Raimondo

Published
2010

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