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36 results on '"Giacomello, Roberta"'

2. Comparison of four D‐dimer assays in the context of venous thromboembolism in the emergency department.

Author

Del Ben, Fabio, Fontanini, Elisabetta, Azzarini, Gabriella, Arini, Marina, Marini, Christian, Poli, Giovanni, Pradella, Paola, Parusso, Serena, Santarossa, Liliana, Targa, Federica, Zardo, Lorena, Giacomello, Roberta, and Morelli, Benedetto

Subjects
PULMONARY embolism, PREDICTIVE tests, BLOOD testing, VEINS, SCIENTIFIC observation, CALF muscles, BLOOD vessels, COMPUTED tomography, PROBABILITY theory, FIBRIN fibrinogen degradation products, HOSPITAL emergency services, DESCRIPTIVE statistics, THROMBOEMBOLISM, RESEARCH, COMPARATIVE studies, DATA analysis software, SENSITIVITY & specificity (Statistics), NONPARAMETRIC statistics, EVALUATION
Abstract

Introduction: This observational study conducted across seven emergency care units compares the efficacy of four D‐dimer detection methods, namely HemosIL D‐dimer HS (HS), HemosIL D‐dimer HS‐500 (HS‐500), VIDAS D‐dimer (VIDAS), and HemosIL AcuStar D‐dimer (ACUSTAR). The primary focus is on patients with a clinical suspicion of deep venous thrombosis (DVT) or pulmonary embolism (PE). Methods: A total of 149 samples were collected from patients with suspected DVT or PE. The confirmation of DVT/PE was based on calf ultrasound or computed tomography‐Angiography. Direct comparisons were made between the different detection methods, considering both their analytical performance and clinical utility. Additionally, the impact of an age‐adjusted cut‐off on the diagnostic accuracy of each method was assessed. Results: The results revealed comparable negative predictive value, sensitivity, and specificity across the methods, with a notable exception of increased specificity for HS compared with HS‐500 (50.8% vs. 41.5%, p = 0.03). Further analysis incorporating an age‐adjusted cut‐off demonstrated a significant improvement in specificity for HS. When using the age‐adjusted cut‐off, HS exhibited a substantial increase in specificity compared with HS‐500 (63.1% vs. 49.2%, p = 0.004) and demonstrated significantly higher specificity compared with VIDAS (63.1% vs. 53.8%, p = 0.04). Conclusion: The study emphasizes the nonuniversal effect of an age‐adjusted cut‐off and discusses the potential necessity for different cut‐off values, particularly in the case of HS‐500. These findings contribute to the understanding of D‐dimer detection methods in the context of DVT and PE, providing insights into their relative performances and the potential optimization through age‐adjusted cut‐offs. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Failure of Therapeutic Anticoagulation in COVID-19 Patients With Acute Ischemic Stroke. A Retrospective Multicenter Study

Author

Janes, Francesco, primary, Gigli, Gian Luigi, additional, Kuris, Fedra, additional, Morassi, Mauro, additional, Costa, Paolo, additional, Nesi, Lorenzo, additional, Giacomello, Roberta, additional, Mazzacane, Federico, additional, Leuci, Eleonora, additional, Cavallini, Anna, additional, and Valente, Mariarosaria, additional

Published
2022
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15. Hyperglycemia-induced thrombin formation in diabetes: the possible role of oxidative stress

Author

Ceriello, Antonio, Giacomello, Roberta, Stel, Giuliana, Motz, Enrico, Taboga, Claudio, Tonutti, Laura, Pirisi, Mario, Falleti, Edmondo, and Bartoli, Ettore

Subjects
Physiological aspects, Complications and side effects, Thrombin -- Physiological aspects, Hyperglycemia -- Complications and side effects, Glutathione metabolism -- Physiological aspects
Abstract

Diabetes is characterized by the existence of a thrombosis-prone condition, possibly related to hyperglycemia. However, the mechanism linking hyperglycemia to the activation of the coagulation cascade is still unclear. It [...]

Published
1995

16. A collaborative study by the Working Group on Hemostasis and Thrombosis of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC) on the interference of haemolysis on five routine blood coagulation tests by evaluation of 269 paired haemolysed/non-haemolysed samples

Author

Novelli, Chiara, primary, Vidali, Matteo, additional, Brando, Bruno, additional, Morelli, Benedetto, additional, Andreani, Giovanna, additional, Arini, Marina, additional, Calzoni, Paola, additional, Giacomello, Roberta, additional, Montaruli, Barbara, additional, Muccini, Emanuela, additional, Papa, Angela, additional, Pradella, Paola, additional, Ruocco, Lucia, additional, Siviero, Fosca, additional, Viola, Filomena Gemma, additional, Zanchetta, Mario, additional, Zardo, Lorena, additional, and Lippi, Giuseppe, additional

Published
2018
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17. Fibrinogen plasma levels as a marker of thrombin activation in diabetes

Author

Ceriello, Antonio, Taboga, Claudio, Giacomello, Roberta, Falleti, Edmondo, De Stasio, Gianni, Motz, Enrico, Lizzio, Sebastiano, Gonano, Fabio, and Bartoli, Ettore

Subjects
Physiological aspects, Risk factors, Health aspects, Thrombin -- Health aspects -- Physiological aspects, Fibrinogen -- Physiological aspects -- Health aspects, Cardiovascular diseases -- Risk factors, Type 1 diabetes -- Physiological aspects -- Risk factors
Abstract

This study attempted to verify the existence of a correlation between fibrinogen, a major cardiovascular risk factor in diabetes, and indexes of thrombin generation and action, prothrombin fragment 1 + [...]

Published
1994

18. Lupus anticoagulant

Author

Poz, Alessandra, primary, Pradella, Paola, additional, Azzarini, Gabriella, additional, Santarossa, Liliana, additional, Bardin, Cristina, additional, Zardo, Lorena, additional, and Giacomello, Roberta, additional

Published
2016
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22. Modified activated Partial thromboplastin time during liver transplantation

Author

Colo', Francesca, DAL POS, Lucia, DE STASIO, Gianni, Giacomello, Roberta, Gonano, Cristina, Gonano, Fabio, MARTINEZ LOPEZ DE ARROYABE, Blanca, Mergoni, Paola, Pasetto, Alberto, Pasqualotto, Antonella, Pasqualucci, Alberto, Sabbadini, D. D., Stel, Giuliana, and Tomasello, Dario Carmelo

Published
2000

33. Abstract T MP20.

Author

Sazonova, Irina Y, Janes, Francesco, Waller, Jennifer L, Brittain, Julia E, Gigli, Gian Luigi, Giacomello, Roberta, Hess, David C, and Switzer, Jeffrey A

Published
2014

36. Thrombogenesis in Thrombophilic Pregnancy: Evaluation of Low-Molecular-Weight Heparin Prophylaxis

Author

Roberta Giacomello, Gabriella Zito, Sergio Parco, Germano Bruno, Roberto Simeone, Monica Martinelli, Stefania Luppi, Natalia Maximova, Giuseppe Ricci, Gina Cervi, Simeone, Roberto, Giacomello, Roberta, Bruno, Germano, Parco, Sergio, Maximova, Natalia, Martinelli, Monica, Zito, Gabriella, Luppi, Stefania, Cervi, Gina, and Ricci, Giuseppe

Subjects
Pilot Projects, 030204 cardiovascular system & hematology, 0302 clinical medicine, Peptide Fragment, Protein C deficiency, Pregnancy, Thrombophilia, Protein S deficiency, 030219 obstetrics & reproductive medicine, medicine.diagnostic_test, Thrombogenesis, Obstetrics, Low-Molecular-Weight, Nadroparin, General Medicine, Heparin, Hematology, Anesthesia, Thrombosi, Gestation, Female, Partial Thromboplastin Time, Prothrombin, Case-Control Studie, Human, medicine.drug, Partial thromboplastin time, Adult, medicine.medical_specialty, medicine.drug_class, Low molecular weight heparin, Thrombogenesi, 03 medical and health sciences, Hypercoagulability, Hematologic, medicine, Humans, Pilot Project, Thromboprophylaxis, Hemostasis, business.industry, Pregnancy Complications, Hematologic, Anticoagulant, Anticoagulants, Prothrombin fragment F1 + 2, Thrombosis, Case-Control Studies, Factor Xa Inhibitors, Heparin, Low-Molecular-Weight, Peptide Fragments, Hemostasi, medicine.disease, Pregnancy Complications, Thromboprophylaxi, business, Factor Xa Inhibitor
Abstract

The aim of this study is to investigate thrombogenesis and the hypercoagulable changes in pregnant women affected by thrombophilia who received low-molecular-weight heparin (LWMH) prophylaxis. We included 21 pregnant women affected by thrombophilia treated with LWMH and 20 nontreated normal pregnant women as the control group. The sample group of thrombophilic pregnant women included different conditions (factor V Leiden mutation, protein C deficiency, protein S deficiency, antiphospholipid antibodies syndrome, and combined defects). Three blood samples were collected during pregnancy (i.e., at 16, 20, and 24 weeks) and tested for activated partial thromboplastin time and prothrombin fragment F1 + 2 (F1 + 2); anti-FXa activity was tested only in treated thrombophilic pregnant women. F1 + 2 levels progressively increased during pregnancy in both study groups. However, the F1 + 2 increase in women exposed to heparin prophylaxis was significantly lower than that in normal pregnant women in all 3 measurements carried out during gestation (p < 0.05); a statistically significant inverse correlation between F1 + 2 levels and anti-Xa activity (R = -0.8575, p < 0.05) was observed in treated women during pregnancy. Our findings suggest that F1 + 2 in addition to anti-Xa measurement could be used to adjust LWMH prophylaxis, at least in high-risk pregnant women.

Published
2017

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