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2. AB0713 PAIN CATASTROPHIZING AND ITS DOMAINS HELPLESSNESS AND RUMINATION IMPACT SIGNIFICANTLY ON DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS: DATA FROM A MULTICENTER ITALIAN STUDY

Author

Kun, L., primary, Currado, D., additional, Berardicurti, O., additional, Vomero, M., additional, Marino, A., additional, Biaggi, A., additional, Pilato, A., additional, Corberi, E., additional, Trunfio, F., additional, Orlando, A., additional, Quadrini, M., additional, Saracino, F., additional, Lamberti, L., additional, Navarini, L., additional, and Giacomelli, R., additional

Published
2024
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3. POS1247 CHARACTERIZATION OF 284 PATIENTS PRESENTING WITH CENTRAL NERVOUS SYSTEM INVOLVEMENT AT DIAGNOSIS OF SJÖGREN DISEASE: RESULTS FROM THE SJÖGREN BIG DATA REGISTRY

Author

Alunno, A., primary, Brito-Zerón, P., additional, Carubbi, F., additional, Ng, W. F., additional, Flores-Chávez, A., additional, Szántó, A., additional, Li, X., additional, Rasmussen, A., additional, Dong, X., additional, Priori, R., additional, Olsson, P., additional, Baldini, C., additional, Seror, R., additional, Bootsma, H., additional, Armagan, B., additional, Kaya, B., additional, Gottenberg, J. E., additional, Praprotnik, S., additional, Suzuki, Y., additional, Quartuccio, L., additional, Leavis, H., additional, Hernandez-Molina, G., additional, Inanc, N., additional, Danda, D., additional, Bartoloni, E., additional, Rischmueller, M., additional, Sebastian, A., additional, Silvério-António, M., additional, Reis de Oliveira, F., additional, Kwok, S. K., additional, Kvarnstrom, M., additional, Solans-Laqué, R., additional, Fernandes Moça Trevisani, V., additional, Galisteo, C., additional, Sene, D., additional, Jurcut, C., additional, Fugmann, C., additional, Hofauer, B., additional, Isenberg, D., additional, Atzeni, F., additional, Shimuzu, T., additional, Valim, V., additional, Pasoto, S., additional, González García, A., additional, Retamozo, S., additional, Cipriani, P., additional, Devauchelle-Pensec, V., additional, Melchor Díaz, S., additional, Gheita, T. A., additional, Morcillo, C., additional, Fonseca-Aizpuru, E., additional, Lopez-Dupla, J. M., additional, Giacomelli, R., additional, Nakamura, H., additional, Vázquez, M., additional, Morel, J., additional, Consani-Fernández, S., additional, Akasbi Montalvo, M., additional, Diaz Cuiza, P. E., additional, De Miguel-Campo, B., additional, Lee, A. Y. S., additional, and Ramos-Casals, M., additional

Published
2024
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5. POS1148 MECHANISMS OF PAIN MODULATION BY JAK INHIBITION: UPADACITINIB REGULATES PAIN-RELATED PATHWAYS AND BDNF EXPRESSION IN MICROGLIAL CELLS

Author

Navarini, L., primary, Vomero, M., additional, Corberi, E., additional, Berardicurti, O., additional, Imperatori, G., additional, Currado, D., additional, Kun, L., additional, Trunfio, F., additional, Saracino, F., additional, Lamberti, L., additional, Marino, A., additional, La Barbera, L., additional, Krashia, P., additional, D’amelio, M., additional, and Giacomelli, R., additional

Published
2024
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6. POS0854 HOPELESSNESS LEVELS ARE SIGNIFICANTLY INCREASED IN SYSTEMIC SCLEROSIS PATIENTS AND CORRELATE WITH THE RAYNAUD CONDITION SCORE AND DIGITAL ULCER SEVERITY

Author

Bearzi, P., primary, Minerba, M., additional, Salvolini, C., additional, Quarta, L., additional, Lanaia, G., additional, Currado, D., additional, Marino, A., additional, Corberi, E., additional, Cocchiaro, T., additional, Vizzini, M., additional, Vomero, M., additional, Berardicurti, O., additional, Marcoccia, A., additional, Navarini, L., additional, and Giacomelli, R., additional

Published
2024
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7. The NESSiE Concept for Sterile Neutrinos

Author

Stanco, L., Anokhina, A., Bagulya, A., Benettoni, M., Bernardini, P., Bertolin, A., Brugnera, R., Calabrese, M., Cecchetti, A., Cecchini, S., Chernyavskiy, M., Collazuol, G., Creti, P., Corso, F. Dal, Dalkarov, O., Del Prete, A., De Mitri, I., De Robertis, G., De Serio, M., Esposti, L. Degli, Di Ferdinando, D., Dore, U., Dusini, S., Dzhatdoev, T., Fanin, C., Fini, R. A., Fiore, G., Galati, G., Garfagnini, A., Giacomelli, G., Giacomelli, R., Golovanov, S., Guandalin, C., Guerzoni, M., Klicek, B., Kose, U., Jakovcic, K., Laurenti, G., Laveder, M., Lippi, I., Loddo, F., Longhin, A., Loverre, P., Malenica, M., Mancarella, G., Mandrioli, G., Margiotta, A., Marsella, G., Mauri, N., Medinaceli, E., Mengucci, A., Mezzetto, M., Michinelli, R., Mingazheva, R., Morgunova, O., Muciaccia, M. T., Orecchini, D., Paoloni, A., Papadia, G., Paparella, L., Pastore, A., Patrizii, L., Polukhina, N., Pozzato, M., Roda, M., Roganova, T., Rosa, G., Sahnoun, Z., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spurio, M., Starkov, N., Stipcevic, M., Surdo, A., Tenti, M., Togo, V., Ventura, M., Vladymyrov, M., and Zago, M.

Subjects
High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract

Neutrino physics is nowadays receiving more and more attention as a possible source of information for the long-standing problem of new physics beyond the Standard Model. The recent measurement of the third mixing angle theta13 in the standard mixing oscillation scenario encourages us to pursue the still missing results on leptonic CP violation and absolute neutrino masses. However, several puzzling measurements exist, which deserve an exhaustive evaluation. The NESSiE Collaboration has been setup to undertake a definitive experiment to clarify the muon disappearance measurements at small L/E, which will be able to put severe constraints to any model with more than the three-standard neutrinos, or even to robustly measure the presence of a new kind of neutrino oscillation for the first time. Within the context of the current CERN project, aimed to revitalize the neutrino field in Europe, we will illustrate the achievements that can be obtained by a double muon-spectrometer system, with emphasis on the search for sterile neutrinos., Comment: 13 pages, Proceedings of XV Workshop on Neutrino Telescopes, 11-15 March 2013, Venice, Italy

Published
2013

8. Search for anomalies in the neutrino sector with muon spectrometers and large LArTPC imaging detectors at CERN

Author

Antonello, M., Bagliani, D., Baibussinov, B., Bilokon, H., Boffelli, F., Bonesini, M., Calligarich, E., Canci, N., Centro, S., Cesana, A., Cieslik, K., Cline, D. B., Cocco, A. G., Dequal, D., Dermenev, A., Dolfini, R., De Gerone, M., Dussoni, S., Farnese, C., Fava, A., Ferrari, A., Fiorillo, G., Garvey, G. T., Gatti, F., Gibin, D., Gninenko, S., Guber, F., Guglielmi, A., Haranczyk, M., Holeczek, J., Ivashkin, A., Kirsanov, M., Kisiel, J., Kochanek, I., Kurepin, A., Lagoda, J., Lucchini, G., Louis, W. C., Mania, S., Mannocchi, G., Marchini, S., Matveev, V., Menegolli, A., Meng, G., Mills, G. B., Montanari, C., Nicoletto, M., Otwinowski, S., Palczewki, T. J., Passardi, G., Perfetto, F., Picchi, P., Pietropaolo, F., Plonski, P., Rappoldi, A., Raselli, G. L., Rossella, M., Rubbia, C., Sala, P., Scaramelli, A., Segreto, E., Stefan, D., Stepaniak, J., Sulej, R., Suvorova, O., Terrani, M., Tlisov, D., Van de Water, R. G., Trinchero, G., Turcato, M., Varanini, F., Ventura, S., Vignoli, C., Wang, H. G., Yang, X., Zani, A., Zaremba, K, Benettoni, M., Bernardini, P., Bertolin, A., Brugnera, R., Calabrese, M., Cecchetti, A., Cecchini, S., Collazuol, G., Creti, P., Corso, F. Dal, Del Prete, A., De Mitri, I., De Robertis, G., De Serio, M., Esposti, L. Degli, Di Ferdinando, D., Dore, U., Dusini, S., Fabbricatore, P., Fanin, C., Fini, R. A., Fiore, G., Garfagnini, A., Giacomelli, G., Giacomelli, R., Guandalini, C., Guerzoni, M., Kose, U., Laurenti, G., Laveder, M., Lippi, I., Loddo, F., Longhin, A., Loverre, P., Mancarella, G., Mandrioli, G., Margiotta, A., Marsella, G., Mauri, N., Medinaceli, E., Mengucci, A., Mezzetto, M., Michinelli, R., Muciaccia, M. T., Orecchini, D., Paoloni, A., Papadia, G., Pastore, A., Patrizii, L., Pozzato, M., Rosa, G., Sahnounm, Z., Simone, S., Sioli, M., Sirri, G., Spurio, M., Stanco, L., Surdo, A., Tenti, M., Togo, V., Ventura, M., and Zago, M.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

A new experiment with an intense ~2 GeV neutrino beam at CERN SPS is proposed in order to definitely clarify the possible existence of additional neutrino states, as pointed out by neutrino calibration source experiments, reactor and accelerator experiments and measure the corresponding oscillation parameters. The experiment is based on two identical LAr-TPCs complemented by magnetized spectrometers detecting electron and muon neutrino events at Far and Near positions, 1600 m and 300 m from the proton target, respectively. The ICARUS T600 detector, the largest LAr-TPC ever built with a size of about 600 ton of imaging mass, now running in the LNGS underground laboratory, will be moved at the CERN Far position. An additional 1/4 of the T600 detector (T150) will be constructed and located in the Near position. Two large area spectrometers will be placed downstream of the two LAr-TPC detectors to perform charge identification and muon momentum measurements from sub-GeV to several GeV energy range, greatly complementing the physics capabilities. This experiment will offer remarkable discovery potentialities, collecting a very large number of unbiased events both in the neutrino and antineutrino channels, largely adequate to definitely settle the origin of the observed neutrino-related anomalies., Comment: Contribution to the European Strategy for Particle Physics - Open Symposium Preparatory Group, Kracow 10-12 September 2012

Published
2012

9. Search for 'anomalies' from neutrino and anti-neutrino oscillations at Delta_m^2 ~ 1eV^2 with muon spectrometers and large LAr-TPC imaging detectors

Author

Antonello, M., Bagliani, D., Baibussinov, B., Bilokon, H., Boffelli, F., Bonesini, M., Calligarich, E., Canci, N., Centro, S., Cesana, A., Cieslik, K., Cline, D. B., Cocco, A. G., Dequal, D., Dermenev, A., Dolfini, R., De Gerone, M., Dussoni, S., Farnese, C., Fava, A., Ferrari, A., Fiorillo, G., Garvey, G. T., Gatti, F., Gibin, D., Gninenko, S., Guber, F., Guglielmi, A., Haranczyk, M., Holeczek, J., Ivashkin, A., Kirsanov, M., Kisiel, J., Kochanek, I., Kurepin, A., Łagoda, J., Lucchini, G., Louis, W. C., Mania, S., Mannocchi, G., Marchini, S., Matveev, V., Menegolli, A., Meng, G., Mills, G. B., Montanari, C., Nicoletto, M., Otwinowski, S., Palczewski, T. J., Passardi, G., Perfetto, F., Picchi, P., Pietropaolo, F., Płoński, P., Rappoldi, A., Raselli, G. L., Rossella, M., Rubbia, C., Sala, P., Scaramelli, A., Segreto, E., Stefan, D., Stepaniak, J., Sulej, R., Suvorova, O., Terrani, M., Tlisov, D., Van de Water, R. G., Trinchero, G., Turcato, M., Varanini, F., Ventura, S., Vignoli, C., Wang, H. G., Yang, X., Zani, A., Zaremba, K., Benettoni, M., Bernardini, P., Bertolin, A., Bozza, C., Brugnera, R., Cecchetti, A., Cecchini, S., Collazuol, G., Creti, P., Corso, F. Dal, De Mitri, I., De Robertis, G., De Serio, M., Esposti, L. Degli, Di Ferdinando, D., Dore, U., Dusini, S., Fabbricatore, P., Fanin, C., Fini, R. A., Fiore, G., Garfagnini, A., Giacomelli, G., Giacomelli, R., Grelli, G., Guandalini, C., Guerzoni, M., Kose, U., Laurenti, G., Laveder, M., Lippi, I., Loddo, F., Longhin, A., Loverre, P., Mancarella, G., Mandrioli, G., Margiotta, A., Marsella, G., Mauri, N., Medinaceli, E., Mengucci, A., Mezzetto, M., Michinelli, R., Muciaccia, M. T., Orecchini, D., Paoloni, A., Pastore, A., Patrizii, L., Pozzato, M., Rescigno, R., Rosa, G., Simone, S., Sioli, M., Sirri, G., Spurio, M., Stanco, L., Stellacci, S., Surdo, A., Tenti, M., Togo, V., Ventura, M., and Zago, M.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

This proposal describes an experimental search for sterile neutrinos beyond the Standard Model with a new CERN-SPS neutrino beam. The experiment is based on two identical LAr-TPC's followed by magnetized spectrometers, observing the electron and muon neutrino events at 1600 and 300 m from the proton target. This project will exploit the ICARUS T600, moved from LNGS to the CERN "Far" position. An additional 1/4 of the T600 detector will be constructed and located in the "Near" position. Two spectrometers will be placed downstream of the two LAr-TPC detectors to greatly complement the physics capabilities. Spectrometers will exploit a classical dipole magnetic field with iron slabs, and a new concept air-magnet, to perform charge identification and muon momentum measurements in a wide energy range over a large transverse area. In the two positions, the radial and energy spectra of the nu_e beam are practically identical. Comparing the two detectors, in absence of oscillations, all cross sections and experimental biases cancel out, and the two experimentally observed event distributions must be identical. Any difference of the event distributions at the locations of the two detectors might be attributed to the possible existence of {\nu}-oscillations, presumably due to additional neutrinos with a mixing angle sin^2(2theta_new) and a larger mass difference Delta_m^2_new. The superior quality of the LAr imaging TPC, in particular its unique electron-pi_zero discrimination allows full rejection of backgrounds and offers a lossless nu_e detection capability. The determination of the muon charge with the spectrometers allows the full separation of nu_mu from anti-nu_mu and therefore controlling systematics from muon mis-identification largely at high momenta., Comment: Experiment proposal

Published
2012

10. New Lower Limits on the Lifetime of Heavy Neutrino Radiative Decay

Author

Cecchini, S., Centomo, D., Giacomelli, G., Giacomelli, R., Giorgini, M., Patrizii, L., Popa, V., and Serbanuut, C. G.

Subjects
High Energy Physics - Experiment
Abstract

The data collected during the 2006 total solar eclipse are analyzed in the search for signals produced by a hypothetical radiative decay of massive neutrinos. In the absence of the expected light pattern, we set lower limits for the massive neutrino components proper lifetime. The reached sensitivity indicates thet these are the best limits obtainable with this method., Comment: 15 pages, 9 figures

Published
2009
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11. Results of the Search for Strange Quark Matter and Q-balls with the SLIM Experiment

Author

Cecchini, S., Cozzi, M., Di Ferdinando, D., Errico, M., Fabbri, F., Giacomelli, G., Giacomelli, R., Giorgini, M., Kumar, A., McDonald, J., Mandrioli, G., Manzoor, S., Margiotta, A., Medinaceli, E., Patrizii, L., Pinfold, J., Popa, V., Qureshi, I. E., Saavedra, O., Sahnoun, Z., Sirri, G., Spurio, M., Togo, V., Valieri, C., Velarde, A., and Zanini, A.

Subjects
High Energy Physics - Experiment
Abstract

The SLIM experiment at the Chacaltaya high altitude laboratory was sensitive to nuclearites and Q-balls, which could be present in the cosmic radiation as possible Dark Matter components. It was sensitive also to strangelets, i.e. small lumps of Strange Quark Matter predicted at such altitudes by various phenomenological models. The analysis of 427 m^2 of Nuclear Track Detectors exposed for 4.22 years showed no candidate event. New upper limits on the flux of downgoing nuclearites and Q-balls at the 90% C.L. were established. The null result also restricts models for strangelets propagation through the Earth atmosphere., Comment: 14 pages, 11 EPS figures

Published
2008
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12. Magnetic Monopole Search at high altitude with the SLIM experiment

Author

Balestra, S., Cecchini, S., Cozzi, M., Errico, M., Fabbri, F., Giacomelli, G., Giacomelli, R., Giorgini, M., Kumar, A., Manzoor, S., McDonald, J., Mandrioli, G., Marcellini, S., Margiotta, A., Medinaceli, E., Patrizii, L., Pinfold, J., Popa, V., Qureshi, I. E., Saavedra, O., Sahnoun, Z., Sirri, G., Spurio, M., Togo, V., Velarde, A., and Zanini, A.

Subjects
High Energy Physics - Experiment
Abstract

The SLIM experiment was a large array of nuclear track detectors located at the Chacaltaya high altitude Laboratory (5230 m a.s.l.). The detector was in particular sensitive to Intermediate Mass Magnetic Monopoles, with masses 10^5 < M <10^{12} GeV. From the analysis of the full detector exposed for more than 4 years a flux upper limit of 1.3 x 10^{-15} cm^{-2} s^{-1} sr^{-1} for downgoing fast Intermediate Mass Monopoles was established at the 90% C.L., Comment: 11 pages. 11 EPS figures. Added Fig. 5 and ref. [15]. Added more details in Sect. 2 and 3

Published
2008
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13. Patients’, physicians’, nurses’, and pharmacists’ preferences on the characteristics of biologic agents used in the treatment of rheumatic diseases

Author

Scalone L, Sarzi-Puttini P, Sinigaglia L, Montecucco C, Giacomelli R, Lapadula G, Olivieri I, Giardino AM, Cortesi PA, Mantovani LG, and Mecchia M

Subjects
preferences, biologic drugs, rheumatic disease, decision-making, Medicine (General), R5-920
Abstract

Luciana Scalone,1 Piercarlo Sarzi-Puttini,2 Luigi Sinigaglia,3 Carlomaurizio Montecucco,4 Roberto Giacomelli,5 Giovanni Lapadula,6 Ignazio Olivieri,7,8,† Angela Maria Giardino,9 Paolo Angelo Cortesi,1 Lorenzo Giovanni Mantovani,1 Monica Mecchia9On behalf of the CARA Study Group1Centre of Research on Public Health, University of Milano-Bicocca, and CHARTA Foundation, Milan, Italy; 2Rheumatology Unit, L. Sacco University Hospital, 3Rheumatology Unit, G. Pini Hospital, Milan, Italy; 4University of Pavia School of Medicine, IRCCS Policlinico San Matteo Foundation, Pavia, Italy; 5Rheumatology Unit School of Medicine, University of L’Aquila, L’Aquila, Italy; 6Rheumatology Unit, University of Bari, Bari, Italy; 7Rheumatology Department of Lucania, San Carlo Hospital of Potenza, Potenza, Italy; 8Madonna delle Grazie Hospital of Matera, Matera, Italy; 9MSD Italy, Rome, Italy†Dr Ignazio Olivieri passed away on July 28, 2017Objective: To estimate preferences in relevant treatment characteristics evaluated by different groups involved in the management of patients with rheumatic diseases.Subjects and methods: We surveyed patients with rheumatic diseases, and rheumatologists, nurses, and pharmacists with experience in treatment with/provision of biologic drugs for these patients. Through a discrete choice experiment, participants evaluated 16 possible scenarios in which pairs of similarly efficacious treatments were described with six characteristics: 1) frequency of administration; 2) mode and place of administration; 3) manner, helpfulness, efficiency, and courtesy of health personnel; 4) frequency of reactions at the site of drug administration; 5) severity of generalized undesired/allergic reactions; and 6) additional cost. The direction and strength of preferences toward each characteristic level and the relative importance of each characteristic were estimated through a random-effects conditional logistic regression model.Results: In total, 513 patients, 110 rheumatologists, 51 nurses, and 46 pharmacists from 30 centers in Italy participated. Characteristics 3, 4, and 6 were the most important for every subgroup; 1 was least important for patients and rheumatologists, 2 was least important for pharmacists, and 2 and 5 were least important for nurses. For characteristic 2, pharmacists preferred subcutaneous self-injection with a syringe; nurses preferred assisted infusion at an infusion center close to the patient’s home; patients and rheumatologists preferred subcutaneous self-injection with a pen.Conclusion: The different preferences for some characteristics shown by the different groups can play an important role, together with purely clinical aspects, in the choice and consequent benefit of treatments, contributing also to a more satisfactory use of resources.Keywords: preferences, biologic drugs, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, decision making

Published
2018

14. Bulk Etch Rate Measurements and Calibrations of Plastic Nuclear Track Detectors

Author

Balestra, S., Cozzi, M., Giacomelli, G., Giacomelli, R., Giorgini, M., Kumar, A., Mandrioli, G., Manzoor, S., Margiotta, A. R., Medinaceli, E., Patrizii, L., Popa, V., Qureshi, I. E., Rana, M. A., Sirri, G., Spurio, M., Togo, V., and Valieri, C.

Subjects
Physics - Instrumentation and Detectors
Abstract

New calibrations of CR39 and Makrofol nuclear track detectors have been obtained using 158 A GeV Pb (82+) and In (49+) ions; a new method for the bulk etch rate determination, using both cone height and base diameter measurements was developed. The CR39 charge resolution based on the etch-pit base area measurement is adequate to identify nuclear fragments in the interval 7 <= Z/beta <= 49. For CR39 the detection threshold is at REL~50 MeV cm^2/g, corresponding to a nuclear fragment with Z/beta~7. Base cone area distributions for Makrofol foils exposed to Pb (82+) ions have shown for the first time all peaks due to nuclear fragments with Z > 50; the distribution of the etched cone heights shows well separated individual peaks for Z/beta = 78 - 83 (charge pickup). The Makrofol detection threshold is at REL 2700 MeV cm^2/g, corresponding to a nuclear fragment with Z/beta~50., Comment: 11 pages, 5 EPS figures. Submitted to Nucl. Instr. Meth. B

Published
2006
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15. Search for possible solar neutrino radiative decays during total solar eclipses

Author

Cecchini, S., Centomo, D., Giacomelli, G., Giacomelli, R., and Popa, V.

Subjects
High Energy Physics - Experiment
Abstract

Total solar eclipses (TSEs) offer a good opportunity to look for photons produced in possible radiative decays of solar neutrinos. In this paper we briefly review the physics bases of such searches as well as the existing limits on the neutrino proper lifetimes obtained by such experiments. We the report on the observations performed in occasion of the 29 March 2006 TSE, from Waw an Namos, Libya., Comment: Presented at the SPSE2006, Waw an Namos, Libya, 27-29 March 2006

Published
2006

16. Rare Particle Searches with the high altitude SLIM experiment

Author

Balestra, S., Cecchini, S., Fabbri, F., Giacomelli, G., Giacomelli, R., Giorgini, M., Kumar, A., Manzoor, S., McDonald, J., Margiotta, A., Medinaceli, E., Nogales, J., Patrizii, L., Popa, V., Quereshi, I., Saavedra, O., Sher, G., Shahzad, M., Spurio, M., Ticona, R., Togo, V., Velarde, A., and Zanini, A.

Subjects
High Energy Physics - Experiment
Abstract

The search for rare particles in the cosmic radiation remains one of the main aims of non-accelerator particle astrophysics. Experiments at high altitude allow lower mass thresholds with respect to detectors at sea level or underground. The SLIM experiment is a large array of nuclear track detectors located at the Chacaltaya High Altitude Laboratory (5290 m a.s.l.). The preliminary results from the analysis of a part of the first 236 sq.m exposed for more than 3.6 y are here reported. The detector is sensitive to Intermediate Mass Magnetic Monopoles and to SQM nuggets and Q-balls, which are possible Dark Matter candidates., Comment: Paper presented by G. Giacomelli at the European Conference on High Energy Physics, July 21-27 2005, Lisboa, Portugal

Published
2006

17. Search for nuclearites with the SLIM detector

Author

Balestra, S., Cecchini, S., Giacomelli, G., Giacomelli, R., Giorgini, M., Manzoor, S., Patrizii, L., Popa, V., and Saavedra, O.

Subjects
High Energy Physics - Experiment
Abstract

The strange quark matter (SQM) may be the ground state of QCD; nuggets of SQM could be present in cosmic rays (CR). SLIM is a large area experiment, using CR39 and Makrofol track etch detectors, presently deployed at the high altitude CR Laboratory of Chacaltaya, Bolivia. We discuss the expected properties of SQM, from the point of view of its search with SLIM. We present also some preliminary results from SLIM., Comment: Presented at the C2CR Conference, Prague, 2005

Published
2006

18. Science,technology and society

Author

Giacomelli, G. and Giacomelli, R.

Subjects
Physics - Physics and Society
Abstract

We shall discuss some aspects of science and technology, their increasing role in the society, the fast advances in modern science, the apparent decrease of interest of the young generation in basic sciences, the importance of proper science popularization for better public education and awareness in scientific fields., Comment: Lecture at the 7th School on Non-Accelerator Astroparticle Physics, Trieste,Italy,2004

Published
2005
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19. Search for possible neutrino radiative decays during the 2001 total solar eclipse

Author

Cecchini, S., Centomo, D., Giacomelli, G., Giacomelli, R., Popa, V., Serbanut, C. G., and Serra, R.

Subjects
High Energy Physics - Experiment
Abstract

We present the results of the observations performed in the occasion of the June 21, 2001 total solar eclipse, looking for visible photons emitted trough a possible radiative decay of solar neutrinos. We establish lower limits for the neutrino proper lifetimes larger than 1000 s/eV, for neutrino masses larger than 0.01 eV., Comment: 18 pages, 11 figures, accepted by Astopart. Phys, updated references

Published
2004
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21. Limits on radiative decays of solar neutrinos from a measurement during a solar eclipse

Author

Cecchini, S., Giacomelli, G., Giacomelli, R., Hasegan, D., Maris, O., Popa, V., Serra, R., Serrazanetti, M., Stefanov, L., Tasca, L., and Valeanu, V.

Subjects
High Energy Physics - Experiment
Abstract

A search for possible radiative decays of solar neutrinos with emission of photons in the visible range was performed during the total solar eclipse of August 11, 1999. Due to very bad weather conditions our two telescopes were unable to collect useful data; fortunately we obtained several video camera images from a local TV station. An analysis of the digitised images is presented and limits on the lifetime for radiative decay are discussed., Comment: 10 pages, 1 tablee, 4 PS figures included with epsfig

Published
2000
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22. Hadron-hadron and hadron-nuclei collisions at high energies

Author

Giacomelli, G. and Giacomelli, R.

Subjects
High Energy Physics - Experiment
Abstract

A brief review is made of the present situation of hadron-hadron and hadron-nuclei total elastic and inelastic cross sections at high energies, Comment: 7 pages

Published
2000

23. POS0237 ADULT-ONSET STILL’S DISEASE AND COVID 19 SHARE GENETIC EXPRESSION RELATED TO HYPERINFLAMMATION: DEFINING THE POSSIBLE ROLE OF THE SPECIALIZED PRO-RESOLVING LIPID MEDIATOR PROTECTIN D1 IN MODULATING MACROPHAGES POLARIZATION AND FUNCTION

Author

Navarini, L., primary, Vomero, M., additional, Currado, D., additional, Berardicurti, O., additional, Biaggi, A., additional, Marino, A., additional, Bearzi, P., additional, Corberi, E., additional, Rigon, A., additional, Arcarese, L., additional, Leuti, A., additional, Fava, M., additional, Fogolari, M., additional, Mattei, A., additional, Ruscitti, P., additional, DI Cola, I., additional, Sambuco, F., additional, Travaglino, F., additional, Angeletti, S., additional, Ursini, F., additional, Mariani, E., additional, Agrò, F. E., additional, Cipriani, P., additional, Iagnocco, A., additional, Antonelli Incalzi, R., additional, Maccarrone, M., additional, and Giacomelli, R., additional

Published
2023
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25. POS0541 INFLAMMATORY RHEUMATIC DISEASES (IRD) WITH ONSET AFTER SARS-COV-2 INFECTION OR COVID-19 VACCINATION: A COHORT STUDY FROM THE COVID-19 & ASD COLLABORATIVE STUDY GROUP

Author

Ursini, F., primary, Ruscitti, P., additional, Addimanda, O., additional, Foti, R., additional, Raimondo, V., additional, Murdaca, G., additional, Caira, V., additional, Pigatto, E., additional, Cuomo, G., additional, Lo Gullo, A., additional, Cavazzana, I., additional, Campochiaro, C., additional, Naclerio, C., additional, De Angelis, R., additional, Ciaffi, J., additional, Mancarella, L., additional, Brusi, V., additional, Marchetti, E., additional, Motta, F., additional, Visentini, M., additional, Lorusso, S., additional, De Santis, M., additional, De Luca, G., additional, Massaro, L., additional, Olivo, D., additional, Pellegrini, R., additional, Luppino, J. M. E., additional, DI Cola, I., additional, Varcasia, G., additional, Caso, F., additional, Reta, M., additional, Dagna, L., additional, Selmi, C., additional, Iagnocco, A., additional, Giacomelli, R., additional, Iannone, F., additional, and Ferri, C., additional

Published
2023
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26. AB0431 CANAKINUMAB AS FIRST-LINE BIOLOGICAL THERAPY IN STILL’S DISEASE AND DIFFERENCES BETWEEN THE SYSTEMIC AND THE CHRONIC-ARTICULAR COURSES: REAL-LIFE EXPERIENCE FROM THE INTERNATIONAL AIDA REGISTRY

Author

Vitale, A., primary, Caggiano, V., additional, Maggio, M. C., additional, Lopalco, G., additional, Emmi, G., additional, Sota, J., additional, La Torre, F., additional, Ruscitti, P., additional, Bartoloni, E., additional, Conti, G., additional, Fabiani, C., additional, Mattioli, I., additional, Gaggiano, C., additional, Cardinale, F., additional, Dagna, L., additional, Campochiaro, C., additional, Giacomelli, R., additional, Balistreri, A., additional, Laskari, K., additional, Tufan, A., additional, Ragab, G., additional, Almaghlouth, I., additional, Więsik-Szewczyk, E., additional, Pereira, R. M., additional, Frediani, B., additional, Iannone, F., additional, Sfikakis, P., additional, and Cantarini, L., additional

Published
2023
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31. Childhood-onset of primary Sjögren’s syndrome: phenotypic characterization at diagnosis of 158 children

Author

Ramos-Casals, M., Acar-Denizli, N., Vissink, A., Brito-Zeron, P., Li, X., Carubbi, F., Priori, R., Toplak, N., Baldini, C., Faugier-Fuentes, E., Kruize, A. A., Mandl, T., Tomiita, M., Gandolfo, S., Hashimoto, K., Hernandez-Molina, G., Hofauer, B., Mendieta-Zeron, S., Rasmussen, A., Sandhya, P., Sene, D., Trevisani, V. F. M., Isenberg, D., Sundberg, E., Pasoto, S. G., Sebastian, A., Suzuki, Y., Retamozo, S., Xu, B., Giacomelli, R., Gattamelata, A., Bizjak, M., Bombardieri, S., Loor-Chavez, R. -E., Hinrichs, A., Olsson, P., Bootsma, H., Lieberman, S. M., Kostov, B., Horvath, I. -F., Szanto, A., Seror, R., Mariette, X., Kvarnstrom, M., Wahren-Herlenius, M., Praprotnik, S., Solans, R., Nordmark, G., Hammenfors, D., Brun, J. G., Gheita, T. A., Atzeni, F., Armagan, B., Kilic, L., Kalyoncu, U., Nakamura, T., Takagi, Y., Consani, S., Solorzano, F. O., Translational Immunology Groningen (TRIGR), Personalized Healthcare Technology (PHT), Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, and Universitat Politècnica de Catalunya. ADBD - Anàlisi de Dades Complexes per a les Decisions Empresarials

Subjects
Male, Systemic disease, Anti-nuclear antibody, Epidemiology, Autoimmune diseases, Matemàtiques i estadística::Matemàtica aplicada a les ciències [Àrees temàtiques de la UPC], Disease, Severity of Illness Index, Parotid Gland, Medicine, CLASSIFICATION CRITERIA, Pharmacology (medical), Registries, Age of Onset, biology, 92 Biology and other natural sciences::92B Mathematical biology in general [Classificació AMS], Dry eyes, Phenotype, Sjogren's syndrome, Female, epidemiology, Antibody, medicine.symptom, PAROTITIS, medicine.medical_specialty, Biomatemàtica, Adolescent, 62 Statistics::62D05 Sampling theory, sample surveys [Classificació AMS], Childhood, Paediatrics, Humans, Sjogren's Syndrome, paediatrics, AGE, Rheumatology, Peripheral nerve, Rheumatoid factor, autoimmune diseases, Sampling (Statistics), Primary Sjögren Syndrome, childhood, Biomathematics, Matemàtiques i estadística::Estadística aplicada::Estadística biosanitària [Àrees temàtiques de la UPC], business.industry, CLINICAL-FEATURES, medicine.disease, Dry mouth, Dermatology, stomatognathic diseases, biology.protein, Sjogren’s syndrome, CONSENSUS, business, Mostreig (Estadística), Parotitis
Abstract

Objectives To characterize the phenotypic presentation at diagnosis of childhood-onset primary SS. Methods The Big Data Sjögren Project Consortium is an international, multicentre registry using worldwide data-sharing cooperative merging of pre-existing clinical SS databases from the five continents. For this study, we selected those patients in whom the disease was diagnosed below the age of 19 years according to the fulfilment of the 2002/2016 classification criteria. Results Among the 12 083 patients included in the Sjögren Big Data Registry, 158 (1.3%) patients had a childhood-onset diagnosis (136 girls, mean age of 14.2 years): 126 (80%) reported dry mouth, 111 (70%) dry eyes, 52 (33%) parotid enlargement, 118/122 (97%) positive minor salivary gland biopsy and 60/64 (94%) abnormal salivary US study, 140/155 (90%) positive ANA, 138/156 (89%) anti-Ro/La antibodies and 86/142 (68%) positive RF. The systemic EULAR Sjögren’s syndrome disease activity index (ESSDAI) domains containing the highest frequencies of active patients included the glandular (47%), articular (26%) and lymphadenopathy (25%) domains. Patients with childhood-onset primary SS showed the highest mean ESSDAI score and the highest frequencies of systemic disease in 5 (constitutional, lymphadenopathy, glandular, cutaneous and haematological) of the 12 ESSDAI domains, and the lowest frequencies in 4 (articular, pulmonary, peripheral nerve and CNS) in comparison with patients with adult-onset disease. Conclusions Childhood-onset primary SS involves around 1% of patients with primary SS, with a clinical phenotype dominated by sicca features, parotid enlargement and systemic disease. Age at diagnosis plays a key role in modulating the phenotypic expression of the disease.

Published
2021

32. OP0044 CYTOKINE PROFILE, HYPERFERRITINEMIA, AND MULTI-VISCERAL INVOLVEMENT CHARACTERISE MACROPHAGE ACTIVATION SYNDROME COMPLICATING ADULT ONSET STILL’S DISEASE. RESULTS FROM A MULTIDIMENSIONAL EVALUATION

Author

Ruscitti, P., primary, Ursini, F., additional, Berardicurti, O., additional, Masedu, F., additional, Bozzalla Cassione, E., additional, Naldi, S., additional, DI Cola, I., additional, DI Muzio, C., additional, De Stefano, L., additional, DI Nino, E., additional, Sensini, F., additional, Navarini, L., additional, Vomero, M., additional, Bugatti, S., additional, Valenti, M., additional, Mariani, E., additional, Iagnocco, A., additional, Montecucco, C., additional, Giacomelli, R., additional, and Cipriani, P., additional

Published
2022
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34. AB0261 CARDIOMETABOLIC COMORBIDITIES MAY IDENTIFY A MORE SEVERE SUBSET OF RHEUMATOID ARTHRITIS, RESULTS FROM A “REAL-LIFE” STUDY

Author

Ruscitti, P., primary, Conforti, A., additional, DI Muzio, C., additional, Currado, D., additional, Navarini, L., additional, Pavlych, V., additional, DI Cola, I., additional, Sensini, F., additional, Biaggi, A., additional, DI Donato, S., additional, Marino, A., additional, Lorusso, S., additional, Ursini, F., additional, Giacomelli, R., additional, and Cipriani, P., additional

Published
2022
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35. POS1337 ADULT-ONSET STILL’S DISEASE WITH ELDERLY ONSET, RESULTS FROM A MULTICENTRE STUDY AND ASSESSMENT OF AGE INFLUENCE ON CLINICAL FEATURES AND DISEASE OUTCOMES.

Author

DI Cola, I., primary, DI Muzio, C., additional, Conforti, A., additional, Iacono, D., additional, Pantano, I., additional, Rozza, G., additional, Rossi, S., additional, De Stefano, L., additional, Vitale, A., additional, Caso, F., additional, Costa, L., additional, Prete, M., additional, Navarini, L., additional, Sensini, F., additional, Iagnocco, A., additional, Atzeni, F., additional, Guggino, G., additional, Perosa, F., additional, Cantarini, L., additional, Frediani, B., additional, Bugatti, S., additional, Montecucco, C., additional, Ciccia, F., additional, Giacomelli, R., additional, Cipriani, P., additional, and Ruscitti, P., additional

Published
2022
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36. AB1182 SPECIALIZED PRO-RESOLVING MEDIATORS (SPMS) AND INFLAMMATORY NETWORKS IN PATIENTS AFFECTED BY ADULT ONSET STILL’S DISEASE (AOSD) AND COVID-19

Author

Navarini, L., primary, Vomero, M., additional, Berardiucrti, O., additional, Currado, D., additional, Marino, A., additional, Biaggi, A., additional, DI Donato, S., additional, Ursini, F., additional, Ruscitti, P., additional, Meliconi, R., additional, Cipriani, P., additional, Iagnocco, A., additional, Afeltra, A., additional, and Giacomelli, R., additional

Published
2022
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37. POS1267 LONG-TERM SURVEY STUDY OF THE IMPACT OF COVID-19 ON SYSTEMIC AUTOIMMUNE DISEASES. LOW DEATH RATE DESPITE THE INCREASED PREVALENCE OF SYMPTOMATIC INFECTION. ROLE OF PRE-EXISTING INTERSTITIAL LUNG DISEASE AND ONGOING TREATMENTS.

Author

Ferri, C., primary, Raimondo, V., additional, Gragnani, L., additional, Giuggioli, D., additional, Dagna, L., additional, Tavoni, A., additional, Ursini, F., additional, L’andolina, M., additional, Caso, F., additional, Ruscitti, P., additional, Caminiti, M., additional, Foti, R., additional, Riccieri, V., additional, Guiducci, S., additional, Pellegrini, R., additional, Zanatta, E., additional, Varcasia, G., additional, Olivo, D., additional, Gigliotti, P., additional, Cuomo, G., additional, Murdaca, G., additional, Cecchetti, R., additional, De Angelis, R., additional, Romeo, N., additional, Ingegnoli, F., additional, Cozzi, F., additional, Codullo, V., additional, Cavazzana, I., additional, Colaci, M., additional, Abignano, G., additional, De Santis, M., additional, Lubrano, E., additional, Fusaro, E., additional, Spinella, A., additional, Lumetti, F., additional, De Luca, G., additional, Bellando Randone, S., additional, Visalli, E., additional, Dal Bosco, Y., additional, Amato, G., additional, Giannini, D., additional, Bilia, S., additional, Masini, F., additional, Pellegrino, G., additional, Pigatto, E., additional, Generali, E., additional, Pagano Mariano, G., additional, Pettiti, G., additional, Zanframundo, G., additional, Brittelli, R., additional, Aiello, V., additional, Caminiti, R., additional, Scorpiniti, D., additional, Ferrari, T., additional, Campochiaro, C., additional, Brusi, V., additional, Fredi, M., additional, Moschetti, L., additional, Cacciapaglia, F., additional, Ferrari, S. M., additional, DI Cola, I., additional, Vadacca, M., additional, Lorusso, S., additional, Monti, M., additional, Lorini, S., additional, Paparo, S. R., additional, Ragusa, F., additional, Elia, G., additional, Mazzi, V., additional, Aprile, M. L., additional, Tasso, M., additional, Miccoli, M., additional, Bosello, S. L., additional, D’angelo, S., additional, Doria, A., additional, Franceschini, F., additional, Meliconi, R., additional, Matucci-Cerinic, M., additional, Iannone, F., additional, Giacomelli, R., additional, Salvarani, C., additional, Zignego, A. L., additional, Fallahi, P., additional, and Antonelli, A., additional

Published
2022
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38. PO-1145 IORT for Brain Metastases: Final First-Stage Results of a Single-Arm, Open-Label, Phase 2 Trial

Author

Castro, D., primary, Sanematsu, P., additional, Pellizzon, A.C., additional, Suzuki, S., additional, Fogaroli, R., additional, Dias, J.E., additional, Gondim, G., additional, Estrada, D., additional, Silva, M.L., additional, Rassi, M., additional, Chen, M., additional, Giacomelli, R., additional, Ramos, H., additional, Neto, E., additional, Abrahão, C., additional, Coelho, T., additional, Yu, L., additional, Tannous, C., additional, Calsavara, V., additional, Giordano, F., additional, and Oliveira, J., additional

Published
2022
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41. Development and implementation of the AIDA International Registry for patients with Behçet's disease

Author

Vitale, A, Della Casa, F, Ragab, G, Almaghlouth, Ia, Lopalco, G, Pereira, Rm, Guerriero, S, Govoni, M, Sfikakis, Pp, Giacomelli, R, Ciccia, F, Monti, S, Ruscitti, P, Piga, M, Lomater, C, Tufan, A, Opris-Belinski, D, Emmi, G, Hernández-Rodríguez, J, Şahin, A, Sebastiani, Gd, Bartoloni, E, Akkoç, N, Gündüz, Ös, Cattalini, M, Conti, Giorgio, Hatemi, G, Maier, A, Parronchi, P, Del Giudice, E, Erten, S, Insalaco, A, Li Gobbi, F, Maggio, Mc, Shahram, F, Caggiano, V, Hegazy, Mt, Asfina, Kn, Morrone, M, Prado, Ll, Dammacco, R, Ruffilli, F, Arida, A, Navarini, L, Pantano, I, Cavagna, L, Conforti, A, Cauli, A, Marucco, Em, Kucuk, H, Ionescu, R, Mattioli, I, Espinosa, G, Araújo, O, Karkaş, B, Canofari, C, Sota, J, Laymouna, Ah, Bedaiwi, Aa, Colella, S, Giardini, Ham, Albano, V, Lo Monaco, A, Fragoulis, Ge, Kardas, Rc, Berlengiero, V, Hussein, Ma, Ricci, F, La Torre, F, Rigante, Donato, Więsik-Szewczyk, E, Frassi, M, Gentileschi, S, Tosi, Gm, Dagostin, Ma, Mahmoud, Aaa, Tarsia, M, Alessio, G, Cimaz, R, Giani, T, Gaggiano, C, Iannone, F, Cipriani, P, Mourabi, M, Spedicato, V, Barneschi, S, Aragona, E, Balistreri, A, Frediani, B, Fabiani, C, Cantarini, L, Autoinflammatory Diseases Alliance (AIDA) Network, Vitale, Antonio, Della Casa, Francesca, Ragab, Gaafar, Almaghlouth, Ibrahim A, Lopalco, Giuseppe, Pereira, Rosa Maria, Guerriero, Silvana, Govoni, Marcello, Sfikakis, Petros P, Giacomelli, Roberto, Ciccia, Francesco, Monti, Sara, Ruscitti, Piero, Piga, Matteo, Lomater, Claudia, Tufan, Abdurrahman, Opris-Belinski, Daniela, Emmi, Giacomo, Hernández-Rodríguez, José, Şahin, Ali, Sebastiani, Gian Domenico, Bartoloni, Elena, Akkoç, Nurullah, Gündüz, Özgül Soysal, Cattalini, Marco, Conti, Giovanni, Hatemi, Gulen, Maier, Armin, Parronchi, Paola, Del Giudice, Emanuela, Erten, Sukran, Insalaco, Antonella, Li Gobbi, Francesca, Maggio, Maria Cristina, Shahram, Farhad, Caggiano, Valeria, Hegazy, Mohamed Tharwat, Asfina, Kazi Nur, Morrone, Maria, Prado, Leandro L, Dammacco, Rosanna, Ruffilli, Francesca, Arida, Aikaterini, Navarini, Luca, Pantano, Ilenia, Cavagna, Lorenzo, Conforti, Alessandro, Cauli, Alberto, Marucco, Elena Maria, Kucuk, Hamit, Ionescu, Ruxandra, Mattioli, Irene, Espinosa, Gerard, Araújo, Olga, Karkaş, Burak, Canofari, Claudia, Sota, Jurgen, Laymouna, Ahmed Hatem, Bedaiwi, Asma A, Colella, Sergio, Giardini, Henrique Ayres M, Albano, Valeria, Lo Monaco, Andrea, Fragoulis, George E, Kardas, Riza Can, Berlengiero, Virginia, Hussein, Mohamed A, Ricci, Francesca, La Torre, Francesco, Rigante, Donato, Więsik-Szewczyk, Ewa, Frassi, Micol, Gentileschi, Stefano, Tosi, Gian Marco, Dagostin, Marilia Ambiel, Mahmoud, Ayman Abdel-Monem Ahmed, Tarsia, Maria, Alessio, Giovanni, Cimaz, Rolando, Giani, Teresa, Gaggiano, Carla, Iannone, Florenzo, Cipriani, Paola, Mourabi, Mariam, Spedicato, Veronica, Barneschi, Sara, Aragona, Emma, Balistreri, Alberto, Frediani, Bruno, Fabiani, Claudia, and Cantarini, Luca

Subjects
Adult, Registrie, Autoinflammatory disease, Registry, Settore MED/16 - REUMATOLOGIA, precision medicine, behçet’s disease, Settore MED/38 - Pediatria Generale E Specialistica, Retrospective Studie, Internal Medicine, Humans, Prospective Studies, Registries, Child, international registry, Retrospective Studies, Behçet's disease, autoinflammatory diseases, rare diseases, uveitis, Behcet Syndrome, Prospective Studie, Uveiti, Emergency Medicine, Rare disease, Human
Abstract

Purpose of the present paper is to point out the design, development and deployment of the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to pediatric and adult patients with Behçet’s disease (BD). The Registry is a clinical physician-driven non-population- and electronic-based instrument implemented for the retrospective and prospective collection of real-life data about demographics, clinical, therapeutic, laboratory, instrumental and socioeconomic information from BD patients; the Registry is based on the Research Electronic Data Capture (REDCap) tool, which is thought to collect standardised information for clinical real-life research, and has been realised to change over time according to future scientific acquisitions and potentially communicate with other existing and future Registries dedicated to BD. Starting from January 31st, 2021, to February 7th, 2022, 110 centres from 23 countries in 4 continents have been involved. Fifty-four of these have already obtained the approval from their local Ethics Committees. Currently, the platform counts 290 users (111 Principal Investigators, 175 Site Investigators, 2 Lead Investigators, and 2 data managers). The Registry collects baseline and follow-up data using 5993 fields organised into 16 instruments, including patient’s demographics, history, clinical manifestations and symptoms, trigger/risk factors, therapies and healthcare access. The development of the AIDA International Registry for BD patients will facilitate the collection of standardised data leading to real-world evidence, enabling international multicentre collaborative research through data sharing, international consultation, dissemination of knowledge, inclusion of patients and families, and ultimately optimisation of scientific efforts and implementation of standardised care.Trial registration NCT05200715 in 21/01/2022.

Published
2022

42. Correction to: Impact of smoking habit on adult-onset Still’s disease prognosis, findings from a multicentre observational study (Clinical Rheumatology, (2022), 41, 3, (641-647), 10.1007/s10067-021-05929-8)

Author

Ruscitti, P., Di Cola, I., Berardicurti, O., Conforti, A., Iacono, D., Pantano, I., Rozza, G., Rossi, S., De Stefano, L., Balduzzi, S., Vitale, A., Caso, F., Costa, L., Prete, M., Navarini, L., Atzeni, F., Guggino, G., Perosa, F., Cantarini, L., Frediani, B., Montecucco, C., Ciccia, F., Giacomelli, R., and Cipriani, P.

Published
2022

43. Development and Implementation of the AIDA International Registry for Patients With Still's Disease

Author

Vitale, A. Della Casa, F. Lopalco, G. Pereira, R.M. Ruscitti, P. Giacomelli, R. Ragab, G. La Torre, F. Bartoloni, E. Del Giudice, E. Lomater, C. Emmi, G. Govoni, M. Maggio, M.C. Maier, A. Makowska, J. Ogunjimi, B. Sfikakis, P.P. Sfriso, P. Gaggiano, C. Iannone, F. Dagostin, M.A. Di Cola, I. Navarini, L. Ahmed Mahmoud, A.A. Cardinale, F. Riccucci, I. Paroli, M.P. Marucco, E.M. Mattioli, I. Sota, J. Abbruzzese, A. Antonelli, I.P.B. Cipriani, P. Tufan, A. Fabiani, C. Ramadan, M.M. Cattalini, M. Kardas, R.C. Sebastiani, G.D. Giardini, H.A.M. Hernández-Rodríguez, J. Mastrorilli, V. Więsik-Szewczyk, E. Frassi, M. Caggiano, V. Telesca, S. Giordano, H.F. Guadalupi, E. Giani, T. Renieri, A. Colella, S. Cataldi, G. Gentile, M. Fabbiani, A. Al-Maghlouth, I.A. Frediani, B. Balistreri, A. Rigante, D. Cantarini, L. The Autoinflammatory Diseases Alliance (AIDA) Network

Abstract

Objective: Aim of this paper is to present the design, construction, and modalities of dissemination of the AutoInflammatory Disease Alliance (AIDA) International Registry for patients with systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD), which are the pediatric and adult forms of the same autoinflammatory disorder. Methods: This Registry is a clinical, physician-driven, population- and electronic-based instrument implemented for the retrospective and prospective collection of real-world data. The collection of data is based on the Research Electronic Data Capture (REDCap) tool and is intended to obtain evidence drawn from routine patients' management. The collection of standardized data is thought to bring knowledge about real-life clinical research and potentially communicate with other existing and future Registries dedicated to Still's disease. Moreover, it has been conceived to be flexible enough to easily change according to future scientific acquisitions. Results: Starting from June 30th to February 7th, 2022, 110 Centers from 23 Countries in 4 continents have been involved. Fifty-four of these have already obtained the approval from their local Ethics Committees. Currently, the platform counts 290 users (111 Principal Investigators, 175 Site Investigators, 2 Lead Investigators, and 2 data managers). The Registry collects baseline and follow-up data using 4449 fields organized into 14 instruments, including patient's demographics, history, clinical manifestations and symptoms, trigger/risk factors, therapies and healthcare access. Conclusions: This international Registry for patients with Still's disease will allow a robust clinical research through collection of standardized data, international consultation, dissemination of knowledge, and implementation of observational studies based on wide cohorts of patients followed-up for very long periods. Solid evidence drawn from “real-life” data represents the ultimate goal of this Registry, which has been implemented to significantly improve the overall management of patients with Still's disease. NCT 05200715 available at https://clinicaltrials.gov/. Copyright © 2022 Vitale, Della Casa, Lopalco, Pereira, Ruscitti, Giacomelli, Ragab, La Torre, Bartoloni, Del Giudice, Lomater, Emmi, Govoni, Maggio, Maier, Makowska, Ogunjimi, Sfikakis, Sfriso, Gaggiano, Iannone, Dagostin, Di Cola, Navarini, Ahmed Mahmoud, Cardinale, Riccucci, Paroli, Marucco, Mattioli, Sota, Abbruzzese, Antonelli, Cipriani, Tufan, Fabiani, Ramadan, Cattalini, Kardas, Sebastiani, Giardini, Hernández-Rodríguez, Mastrorilli, Więsik-Szewczyk, Frassi, Caggiano, Telesca, Giordano, Guadalupi, Giani, Renieri, Colella, Cataldi, Gentile, Fabbiani, Al-Maghlouth, Frediani, Balistreri, Rigante and Cantarini.

Published
2022

44. Addressing the clinical unmet needs in primary Sjögren's Syndrome through the sharing, harmonization and federated analysis of 21 European cohorts

Author

Pezoulas, V.C. Goules, A. Kalatzis, F. Chatzis, L. Kourou, K.D. Venetsanopoulou, A. Exarchos, T.P. Gandolfo, S. Votis, K. Zampeli, E. Burmeister, J. May, T. Marcelino Pérez, M. Lishchuk, I. Chondrogiannis, T. Andronikou, V. Varvarigou, T. Filipovic, N. Tsiknakis, M. Baldini, C. Bombardieri, M. Bootsma, H. Bowman, S.J. Shahnawaz Soyfoo, M. Parisis, D. Delporte, C. Devauchelle-Pensec, V. Pers, J.-O. Dörner, T. Bartoloni, E. Gerli, R. Giacomelli, R. Jonsson, R. Ng, W.-F. Priori, R. Ramos-Casals, M. Sivils, K. Skopouli, F. Torsten, W. A. G. van Roon, J. Xavier, M. De Vita, S. Tzioufas, A.G. Fotiadis, D.I.

Abstract

For many decades, the clinical unmet needs of primary Sjögren's Syndrome (pSS) have been left unresolved due to the rareness of the disease and the complexity of the underlying pathogenic mechanisms, including the pSS-associated lymphomagenesis process. Here, we present the HarmonicSS cloud-computing exemplar which offers beyond the state-of-the-art data analytics services to address the pSS clinical unmet needs, including the development of lymphoma classification models and the identification of biomarkers for lymphomagenesis. The users of the platform have been able to successfully interlink, curate, and harmonize 21 regional, national, and international European cohorts of 7,551 pSS patients with respect to the ethical and legal issues for data sharing. Federated AI algorithms were trained across the harmonized databases, with reduced execution time complexity, yielding robust lymphoma classification models with 85% accuracy, 81.25% sensitivity, 85.4% specificity along with 5 biomarkers for lymphoma development. To our knowledge, this is the first GDPR compliant platform that provides federated AI services to address the pSS clinical unmet needs. © 2022 The Author(s)

Published
2022

46. List of Contributors

Author

Alunno, A., primary, Appel, S., additional, Astorri, E., additional, Baldini, C., additional, Barone, F., additional, Bartoloni, E., additional, Bombardieri, M., additional, Bombardieri, S., additional, Bowman, S.J., additional, Campos, J., additional, Carubbi, F., additional, Cipriani, P., additional, Colafrancesco, S., additional, De Vita, S., additional, Del Papa, N., additional, Devauchelle-Pensec, V., additional, Felten, R., additional, Fisher, B.A., additional, Fox, C.M., additional, Fox, R.I., additional, Gandolfo, S., additional, Gerli, R., additional, Giacomelli, R., additional, Gottenberg, J.-E., additional, Jonsson, R., additional, Kapsogeorgou, E.K., additional, Kyttaris, V.C., additional, Lucchesi, D., additional, Lunardi, C., additional, Manoussakis, M.N., additional, Mavragani, C.P., additional, Patuzzo, G., additional, Perricone, C., additional, Pers, J.-O., additional, Pitzalis, C., additional, Priori, R., additional, Quartuccio, L., additional, Shoenfeld, Y., additional, Sibilia, J., additional, Tinazzi, E., additional, Tsokos, G.C., additional, Tzioufas, A.G., additional, Valesini, G., additional, Vitali, C., additional, and Youinou, P., additional

Published
2016
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47. Advanced diagnostic imaging and intervention in tendon diseases

Author

Bruno, F., Palumbo, P., Arrigoni, F., Mariani, S., Aringhieri, G., Carotti, M., Natella, R., Zappia, M., Cipriani, P., Giacomelli, R., Di Cesare, E., Splendiani, A., Masciocchi, C., and Barile, A.

Subjects
Tendons, tendinosis, T2 mapping, tendon, ultrasound elastography, Humans, Review, Musculoskeletal Diseases, MRI, Tendinosis, Tendon, Ultrasound elastography, musculoskeletal system, Magnetic Resonance Imaging
Abstract

Degenerative tendon pathology represents one of the most frequent and disabling musculoskeletal disorders. Diagnostic radiology plays a fundamental role in the clinical evaluation of tendon pathologies. Moreover, several minimally invasive treatments can be performed under imaging guidance to treat tendon disorders, maximizing the efficacy and reducing procedural complications. In this review article we describe the most relevant diagnostic features of conventional and advanced US and MRI imaging in tendon disorders, along with the main options for image-guided intervention. (www.actabiomedica.it)

Published
2020

48. GENDER AND FIBROMYALGIA SEVERITY: REAL LIFE DATA FROM THE ITALIAN REGISTRY

Author

Batticciotto, A, Campanaro, F, Atzeni, F, Alciati, A, Di Carlo, M, Bazzichi, L, Govoni, M, Biasi, G, Di Franco, M, Mozzani, F, Gremese, E, Dagna, L, Fischetti, F, Giacomelli, R, Guiducci, S, Guggino, G, Bentivegna, M, Gerli, R, Salvarani, C, Bajocchi, G, Ghini, M, Iannone, F, Giorgi, V, Farah, S, Bonazza, S, Barbagli, S, Gioia, C, Capacci, A, Cavalli, G, Carubbi, F, Nacci, F, Ilenia, R, Sinigaglia, L, Cutolo, M, Cappelli, A, Sarzi-Puttini, P, Salaffi, F, Batticciotto, A, Campanaro, F, Atzeni, F, Alciati, A, Di Carlo, M, Bazzichi, L, Govoni, M, Biasi, G, Di Franco, M, Mozzani, F, Gremese, E, Dagna, L, Fischetti, F, Giacomelli, R, Guiducci, S, Guggino, G, Bentivegna, M, Gerli, R, Salvarani, C, Bajocchi, G, Ghini, M, Iannone, F, Giorgi, V, Farah, S, Bonazza, S, Barbagli, S, Gioia, C, Capacci, A, Cavalli, G, Carubbi, F, Nacci, F, Ilenia, R, Sinigaglia, L, Cutolo, M, Cappelli, A, Sarzi-Puttini, P, and Salaffi, F

Subjects
Fibromyalgia, Rheumatology
Abstract

Background: Fibromyalgia (FM) patients report chronic widespread pain, fatigue, cognitive difficulties and sleep disturbances, often associated with anxiety and/or depression (1). FM syndrome more frequently affects women and many papers describe gender-related differences in the perception, description and expression of pain (2), but up to now, the impact of gender on the clinical severity of FM is still a controversial topic. Objectives: The aim of this study was to analyse the data from a web-based registry of FM patients in order to detect a relationship between gender and disease severity. Methods: Adult patients with FM, diagnosed on the basis of the 2010/2011 American College of Rheumatology (ACR) diagnostic criteria (3), were recruited at 19 Italian rheumatology centres between November 2018 and April 2019. Those affected by other conditions that could interfere with the assessment of FM, e.g. psychiatric disorders, were excluded from the study. The severity of the disease was evaluated by validated FM-specific questionnaires: the revised Fibromyalgia Impact Questionnaire (FIQR) (4), the modified Fibromyalgia Assessment Status (ModFAS) questionnaire (5), and the Polysymptomatic Distress Scale (PDS) (6). The data obtained were collected in the Italian Fibromyalgia Registry, an online registry created with the support of the Italian Society of Rheumatology (SIR). Results: We analyse data from 2.381 patients affected by FM, 2.184 females (91.7%) and 197 males. No significant differences in mean age, disease duration, or BMI between the two genders were reported. The women expressed greater disease burden as indicated by higher scores for each completed test: higher mean ModFAS score (25.23 ± 8.83 Vs 23.37 ± 9.22; p = 0.005), mean FIQR score (58.62 ± 23.22 Vs 51.68 ± 23.06; p

Published
2021

49. Influence of the age at diagnosis in the disease expression of primary Sjögren's syndrome: Analysis of 12,753 patients from the Sjögren Big Data Consortium

Author

Retamozo, S., Acar-Denizli, N., Horváth, I. F., Ng, W. -F, Rasmussen, A., Dong, X., Li, X., Baldini, C., Olsson, P., Priori, R., Seror, R., Gottenberg, J. -E, Kruize, A. A., Hernandez-Molina, G., Vissink, A., Sandhya, P., Armagan, B., Quartuccio, L., Sebastian, A., Praprotnik, S., Bartoloni, E., Kwok, S. -K, Kvarnstrom, M., Rischmueller, M., Soláns-Laqué, R., Sene, D., Pasoto, S. G., Suzuki, Y., Isenberg, D. A., Valim, V., Nordmark, G., Nakamura, H., Virginia Trevisani, Hofauer, B., Sisó-Almirall, A., Giacomelli, R., Devauchelle-Pensec, V., Bombardieri, M., Atzeni, F., Hammenfors, D., Maure, B., Carsons, S. E., Gheita, T., Sánchez-Berná, I., López-Dupla, M., Morel, J., Inanç, N., Fonseca-Aizpuru, E., Morcillo, C., Vollenweider, C., Melchor, S., Vázquez, M., Díaz-Cuiza, E., Consani-Fernández, S., De-Miguel-Campo, B., Szántó, A., Bombardieri, S., Gattamelata, A., Hinrichs, A., Sánchez-Guerrero, J., Danda, D., Kilic, L., Vita, S., Wiland, P., Gerli, R., Park, S. -H, Wahren-Herlenius, M., Bootsma, H., Mariette, X., Ramos-Casals, M., Brito-Zerón, P., Translational Immunology Groningen (TRIGR), and Personalized Healthcare Technology (PHT)

Subjects
immunological markers, MANIFESTATIONS, age, Sjogren's syndrome, ONSET, YOUNG, MANAGEMENT, LYMPHOMA, disease phenotype, CLASSIFICATION CRITERIA, CONSENSUS, PROJECT, SALIVARY FLOW
Abstract

Objective. To analyse how the main components of the disease phenotype (sicca symptoms, diagnostic tests, immunological markers and systemic disease) can be driven by the age at diagnosis of primary Sjogren's syndrome (pSS). Methods. By January 2021, the participant centres had included 12,753 patients from 25 countries that fulfilled the 2002/2016 classification criteria for pSS. The age at diagnosis was defined as the time when the attending physician confirmed fulfilment of the criteria. Patients were clustered according to age at diagnosis. 50 clusters with more than 100 observations (from 27 to 76 years) were used to study the influence of the age at diagnosis in the disease expression. Results. There was a consistent increase in the frequency of oral dryness according to the age at diagnosis, with a frequency of 95% in those diagnosed at the oldest ages. The smooth curves that best fitted a linear model were the frequency of dry mouth (adjusted R-2 0.87) and the frequency of abnormal oral tests (adjusted R-2 0.72). Therefore, for each 1-year increase in the age at diagnosis, the frequency of dry mouth increased by 0.13%, and the frequency of abnormal oral diagnostic tests by 0.11%. There was a consistent year-by-year decrease in the frequency of all autoantibodies and immunological markers except for cryoglobulins. According to the linear models, for each 1-year increase in the age at diagnosis, the frequency of a positive result decreased by 0.57% (for anti-Ro antibodies), 0.47% (for RF) and 0.42% (for anti-La antibodies). The ESSDAI domains which showed a more consistent decrease were glandular and lymph node involvement (for each 1-year increase in the age at diagnosis, the frequency of activity decreased by 0.18%), and constitutional, cutaneous, and haematological involvements (the frequency decreased by 0.09% for each 1-year increase). In contrast, other domains showed an ascending pattern, especially pulmonary involvement (for each 1-year increase in the age at diagnosis, the frequency of activity increased by 0.22%), and peripheral nerve involvement (the frequency increased by 0.09% for each 1-year increase). Conclusion. The influence of the age at diagnosis on the key phenotypic features of pSS is strong, and should be considered critical not only for designing a personalised diagnostic approach, but also to be carefully considered when analysing the results of diagnostic tests and immunological parameters, and when internal organ involvement is suspected at diagnosis.

Published
2021

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