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23 results on '"Giacobino, Davide"'

2. Relative Tumour Volume in Canine Oral Melanoma Staging and Prognosis.

Author

Silva, Marta L., Martinho, Inês, Rocha, Margarida, Martano, Marina, Spindler, Kevin P., Buracco, Paolo, Giacobino, Davide, Florindo, Helena F., and Mestrinho, Lisa A.

Subjects
LYMPHATIC metastasis, PHENOTYPIC plasticity, SURGICAL margin, REFERENCE values, SURVIVAL analysis (Biometry)
Abstract

Melanoma is one of the most common canine oral malignant tumours and is highly aggressive and metastatic, even at the early stages of development. Surgery relies on wide excision of the primary tumour and regional lymphadenectomy, with or without adjuvant therapy. Tumour location and size are important when considering staging, which ultimately affects the curative intent of surgery. Nevertheless, absolute tumour volume (TV) is not related to the vast phenotypic variability within canine breeds. This study aimed to determine the cutoff values of two ratios—tumour‐to‐head volume (THR) and tumour‐to‐body volume (TBR)—and assess whether they could be associated with the odds of finding metastasis at presentation and/or the likelihood of achieving tumour‐free excision margins. A retrospective case series involving 51 dogs was used to evaluate the preoperative head/neck and chest computed tomography and histopathology of the primary mass and excised lymph nodes. Higher TV, THR% and TBR% values were associated with bone lysis and mitotic count (MC). The Ki67 index was significantly associated with local and distant metastases at presentation, whereas MC was associated with local metastasis alone. Tumour‐infiltrated surgical margins were associated with caudally located tumours, regardless of the tumour size. Dogs with lymph node metastasis at presentation were seven times more prone to have local relapse. TV, THR% and TBR% values were positively associated with local lymph node metastasis at presentation. Cutoff values for both TV and TBR% were proposed to predict lymph node metastasis at presentation (TV = 6.423 cm3 and TBR% = 0.043), being supported by post‐surgical survival analysis. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Hypoxia-associated markers in the prognosis of oral canine melanoma

Author

Gola, Cecilia, primary, Maniscalco, Lorella, additional, Iussich, Selina, additional, Morello, Emanuela, additional, Olimpo, Matteo, additional, Martignani, Eugenio, additional, Accornero, Paolo, additional, Giacobino, Davide, additional, Mazzone, Eugenio, additional, Modesto, Paola, additional, Varello, Katia, additional, Aresu, Luca, additional, and De Maria, Raffaella, additional

Published
2024
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6. Sentinel lymph node mapping with computed tomography lymphography for mast cell tumours and a comparison between regional and sentinel lymph node histological status: Sixty‐two cases

Author

Ferraris, Erica Ilaria, primary, Olimpo, Matteo, additional, Giacobino, Davide, additional, Manassero, Luca, additional, Iussich, Selina, additional, Lardone, Elena, additional, Camerino, Mariateresa, additional, Buracco, Paolo, additional, and Morello, Emanuela Maria, additional

Published
2023
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9. Investigating a Prognostic Factor for Canine Hepatocellular Carcinoma: Analysis of Different Histological Grading Systems and the Role of PIVKA-II

Author

Maniscalco, Lorella, primary, Varello, Katia, additional, Morello, Emanuela, additional, Montemurro, Vittoria, additional, Olimpo, Matteo, additional, Giacobino, Davide, additional, Abbamonte, Giuseppina, additional, Gola, Cecilia, additional, Iussich, Selina, additional, and Bozzetta, Elena, additional

Published
2022
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10. Antigen mimicry as an effective strategy to induce CSPG4-targeted immunity in dogs with oral melanoma: a veterinary trial

Author

Riccardo, Federica, primary, Tarone, Lidia, additional, Camerino, Mariateresa, additional, Giacobino, Davide, additional, Iussich, Selina, additional, Barutello, Giuseppina, additional, Arigoni, Maddalena, additional, Conti, Laura, additional, Bolli, Elisabetta, additional, Quaglino, Elena, additional, Merighi, Irene Fiore, additional, Morello, Emanuela, additional, Dentini, Alfredo, additional, Ferrone, Soldano, additional, Buracco, Paolo, additional, and Cavallo, Federica, additional

Published
2022
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12. Prognostic impact of bone invasion in canine oral malignant melanoma treated by surgery and anti‐CSPG4 vaccination: A retrospective study on 68 cases (2010–2020)

Author

Camerino, Mariateresa, primary, Giacobino, Davide, additional, Manassero, Luca, additional, Iussich, Selina, additional, Riccardo, Federica, additional, Cavallo, Federica, additional, Tarone, Lidia, additional, Olimpo, Matteo, additional, Lardone, Elena, additional, Martano, Marina, additional, Del Magno, Sara, additional, Buracco, Paolo, additional, and Morello, Emanuela, additional

Published
2021
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16. Difference in outcome between curative intent vs marginal excision as a first treatment in dogs with oral malignant melanoma and the impact of adjuvant CSPG4‐DNA electrovaccination: A retrospective study on 155 cases

Author

Giacobino, Davide, primary, Camerino, Mariateresa, additional, Riccardo, Federica, additional, Cavallo, Federica, additional, Tarone, Lidia, additional, Martano, Marina, additional, Dentini, Alfredo, additional, Iussich, Selina, additional, Lardone, Elena, additional, Franci, Paolo, additional, Valazza, Alberto, additional, Manassero, Luca, additional, Del Magno, Sara, additional, De Maria, Raffaella, additional, Morello, Emanuela, additional, and Buracco, Paolo, additional

Published
2021
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17. Evaluation of prognostic impact of pre‐treatment neutrophil to lymphocyte and lymphocyte to monocyte ratios in dogs with oral malignant melanoma treated with surgery and adjuvant CSPG4 ‐antigen electrovaccination: an explorative study

Author

Camerino, Mariateresa, primary, Giacobino, Davide, additional, Iussich, Selina, additional, Ala, Ugo, additional, Riccardo, Federica, additional, Cavallo, Federica, additional, Martano, Marina, additional, Morello, Emanuela, additional, and Buracco, Paolo, additional

Published
2021
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18. Evaluation of the neoplastic infiltration of the skin overlying canine subcutaneous soft tissue sarcomas: An explorative study

Author

Del Magno, Sara, primary, Morello, Emanuela, additional, Iussich, Selina, additional, Gola, Cecilia, additional, Dalpozzo, Boris, additional, Annoni, Maurizio, additional, Martano, Marina, additional, Massari, Federico, additional, Giacobino, Davide, additional, Piras, Lisa Adele, additional, Stefanello, Damiano, additional, and Buracco, Paolo, additional

Published
2021
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19. Prognostic impact of clinical, haematological, and histopathological variables in 102 canine cutaneous perivascular wall tumours

Author

Chiti, Lavinia E., primary, Ferrari, Roberta, additional, Boracchi, Patrizia, additional, Morello, Emanuela, additional, Marconato, Laura, additional, Roccabianca, Paola, additional, Avallone, Giancarlo, additional, Iussich, Selina, additional, Giordano, Alessia, additional, Ferraris, Erica I., additional, Agnoli, Chiara, additional, Dondi, Francesco, additional, Giacobino, Davide, additional, Godizzi, Francesco, additional, and Stefanello, Damiano, additional

Published
2021
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20. Prognostic impact of bone invasion in canine oral malignant melanoma treated by surgery and anti‐CSPG4 vaccination: A retrospective study on 68 cases (2010–2020).

Author

Camerino, Mariateresa, Giacobino, Davide, Manassero, Luca, Iussich, Selina, Riccardo, Federica, Cavallo, Federica, Tarone, Lidia, Olimpo, Matteo, Lardone, Elena, Martano, Marina, Del Magno, Sara, Buracco, Paolo, and Morello, Emanuela

Subjects
*MELANOMA, *SOFT palate, *SURVIVAL rate, *UVEA, *OVERALL survival, *ORAL mucosa, *SURVIVAL analysis (Biometry)
Abstract

Prognosis of canine oral malignant melanoma encompasses clinical, histological and immunohistochemical parameters. The aim of this study was to evaluate the prognostic impact of bone invasion in oral canine melanoma. Sixty‐eight dogs bearing oral melanoma staged II and III that underwent surgery and anti‐CSPG4 electrovaccination, with available histological data and a minimum follow up of minimum 1 year, were retrospectively selected. Bone invasion was detected on imaging and/or histology. Median survival time of dogs with evidence of bone invasion (group 1) was 397 days and significantly shorter compared with dogs with oral melanomas not invading the bone (group 2, 1063 days). Dogs with tumours localised at the level of the cheek, lip, tongue and soft palate (soft tissue ‐ group 3) lived significantly longer compared with dogs having tumours within the gingiva of the maxilla or mandible (hard tissue ‐ group 4) with a median survival time of 1063 and 470 days, respectively. Within group 4, the subgroup of dogs with tumours not invading the bone (group 5) showed a significant prolonged survival time (972 days) in comparison with dogs of group 1 (bone invasion group). Similar results were obtained for the disease‐free intervals amongst the different groups. Statistical analysis showed that Ki67 and mitotic count were correlated with shorter survival in patients of group 1 (with bone invasion). Bone invasion should always be assessed since it appears to be a negative prognostic factor. [ABSTRACT FROM AUTHOR]

Published
2022
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21. Supplemental_Figure – Supplemental material for Identification of CSPG4 as a promising target for translational combinatorial approaches in osteosarcoma

Author

Riccardo, Federica, Tarone, Lidia, Iussich, Selina, Giacobino, Davide, Arigoni, Maddalena, Sammartano, Federica, Morello, Emanuela, Martano, Marina, Gattino, Francesca, Maria, Raffaella De, Soldano Ferrone, Buracco, Paolo, and Cavallo, Federica

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Supplemental_Figure for Identification of CSPG4 as a promising target for translational combinatorial approaches in osteosarcoma by Federica Riccardo, Lidia Tarone, Selina Iussich, Davide Giacobino, Maddalena Arigoni, Federica Sammartano, Emanuela Morello, Marina Martano, Francesca Gattino, Raffaella De Maria, Soldano Ferrone, Paolo Buracco and Federica Cavallo in Therapeutic Advances in Medical Oncology

Published
2019
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22. Identification of CSPG4 as a promising target for translational combinatorial approaches in osteosarcoma

Author

Riccardo, Federica, primary, Tarone, Lidia, additional, Iussich, Selina, additional, Giacobino, Davide, additional, Arigoni, Maddalena, additional, Sammartano, Federica, additional, Morello, Emanuela, additional, Martano, Marina, additional, Gattino, Francesca, additional, Maria, Raffaella De, additional, Ferrone, Soldano, additional, Buracco, Paolo, additional, and Cavallo, Federica, additional

Published
2019
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23. A chimeric human/dog-DNA vaccine against CSPG4 induces immunity with therapeutic potential in comparative pre-clinical models of osteosarcoma

Author

Tarone, Lidia, Giacobino, Davide, Camerino, Mariateresa, Maniscalco, Lorella, Iussich, Selina, Parisi, Lorenza, Giovannini, Giuseppe, Dentini, Alfredo, Bolli, Elisabetta, Quaglino, Elena, Merighi, Irene Fiore, Morello, Emanuela, Buracco, Paolo, Riccardo, Federica, and Cavallo, Federica

Abstract

The high mortality rate of osteosarcoma (OSA) patients highlights the requirement of alternative strategies. The young age of patients, as well as the rarity and aggressiveness of the disease, limits opportunities for the robust testing of novel therapies, suggesting the need for valuable pre-clinical systems. Having previously shown the overexpression of the chondroitin sulfate proteoglycan (CSPG)4 in OSA, herein the functional consequences of its downmodulation in human OSA cells were evaluated in vitro, with a significant impairment of cell proliferation, migration, and osteosphere generation. The potential of a chimeric human/dog (HuDo)-CSPG4 DNA vaccine was explored in translational comparative OSA models, including human xenograft mouse models and canine patients affected by spontaneous OSA. The adoptive transfer of HuDo-CSPG4 vaccine-induced CD8+T cells and sera in immunodeficient human OSA-bearing mice delayed tumor growth and metastasis development. HuDo-CSPG4 vaccination resulted safe and effective in inducing anti-CSPG4 immunity in OSA-affected dogs, which displayed prolonged survival as compared with controls. Finally, HuDo-CSPG4 was also able to induce a cytotoxic response in a human surrogate setting in vitro. On the basis of these results and the high predictive value of spontaneous OSA in dogs, this study paves the way for a possible translation of this approach to humans.

Published
2023
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