Author: "Giacalone, JC" - Searchworks@Jio Institute Digital Library Search Results

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1. Overview of JET results for optimising ITER operation

Author: Mailloux, J, Abid, N, Abraham, K, Abreu, P, Adabonyan, O, Adrich, P, Afanasev, V, Afzal, M, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Akhtar, M, Albanese, R, Alderson-Martin, M, Alegre, D, Aleiferis, S, Aleksa, A, Alekseev, A, Alessi, E, Aleynikov, P, Algualcil, J, Ali, M, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amosov, V, Sunden, E, Andrew, P, Angelini, B, Angioni, C, Antoniou, I, Appel, L, Appelbee, C, Aria, S, Ariola, M, Artaserse, G, Arter, W, Artigues, V, Asakura, N, Ash, A, Ashikawa, N, Aslanyan, V, Astrain, M, Asztalos, O, Auld, D, Auriemma, F, Austin, Y, Avotina, L, Aymerich, E, Baciero, A, Bairaktaris, F, Balbin, J, Balbinot, L, Balboa, I, Balden, M, Balshaw, C, Balshaw, N, Bandaru, V, Banks, J, Baranov, Y, Barcellona, C, Barnard, A, Barnard, M, Barnsley, R, Barth, A, Baruzzo, M, Barwell, S, Bassan, M, Batista, A, Batistoni, P, Baumane, L, Bauvir, B, Baylor, L, Beaumont, P, Beckett, D, Begolli, A, Beidler, M, Bekris, N, Beldishevski, M, Belli, E, Belli, F, Belonohy, E, Ben Yaala, M, Benayas, J, Bentley, J, Bergsaker, H, Bernardo, J, Bernert, M, Berry, M, Bertalot, L, Betar, H, Beurskens, M, Bickerton, S, Bieg, B, Bielecki, J, Bierwage, A, Biewer, T, Bilato, R, Bilkova, P, Birkenmeier, G, Bishop, H, Bizarro, J, Blackburn, J, Blanchard, P, Blatchford, P, Bobkov, V, Boboc, A, Bohm, P, Bohm, T, Bolshakova, I, Bolzonella, T, Bonanomi, N, Bonfiglio, D, Bonnin, X, Bonofiglo, P, Boocock, S, Booth, A, Booth, J, Borba, D, Borodin, D, Borodkina, I, Boulbe, C, Bourdelle, C, Bowden, M, Boyd, K, Mihalic, I, Bradnam, S, Braic, V, Brandt, L, Bravanec, R, Breizman, B, Brett, A, Brezinsek, S, Brix, M, Bromley, K, Brown, B, Brunetti, D, Buckingham, R, Buckley, M, Budny, R, Buermans, J, Bufferand, H, Buratti, P, Burgess, A, Buscarino, A, Busse, A, Butcher, D, de la Cal, E, Calabro, G, Calacci, L, Calado, R, Camenen, Y, Canal, G, Cannas, B, Cappelli, M, Carcangiu, S, Card, P, Cardinali, A, Carman, P, Carnevale, D, Carr, M, Carralero, D, Carraro, L, Carvalho, I, Carvalho, P, Casiraghi, I, Casson, F, Castaldo, C, Catalan, J, Catarino, N, Causa, F, Cavedon, M, Cecconello, M, Challis, C, Chamberlain, B, Chang, C, Chankin, A, Chapman, B, Chernyshova, M, Chiariello, A, Chmielewski, P, Chomiczewska, A, Chone, L, Ciraolo, G, Ciric, D, Clark, M, Clarkson, R, Clements, C, Cleverly, M, Coad, J, Coates, P, Cobalt, A, Coccorese, V, Coelho, R, Coenen, J, Coffey, I, Colangeli, A, Colas, L, Collins, C, Collins, J, Collins, S, Conka, D, Conroy, S, Conway, B, Conway, N, Coombs, D, Cooper, P, Cooper, S, Corradino, C, Corrigan, G, Coster, D, Cox, P, Craciunescu, T, Cramp, S, Crapper, C, Craven, D, Craven, R, Esposito, M, Croci, G, Croft, D, Croitoru, A, Crombe, K, Cronin, T, Cruz, N, Crystal, C, Cseh, G, Cufar, A, Cullen, A, Curuia, M, Czarski, T, Dabirikhah, H, Dal Molin, A, Dale, E, Dalgliesh, P, Dalley, S, Dankowski, J, David, P, Davies, A, Davies, S, Davis, G, Dawson, K, Dawson, S, Day, I, De Bock, M, De Temmerman, G, De Tommasi, G, Deakin, K, Deane, J, Dejarnac, R, Del Sarto, D, Delabie, E, Del-Castillo-Negrete, D, Dempsey, A, Dendy, R, Devynck, P, Di Siena, A, Di Troia, C, Dickson, T, Dinca, P, Dittmar, T, Dobrashian, J, Doerner, R, Donne, A, Dorling, S, Dormido-Canto, S, Douai, D, Dowson, S, Doyle, R, Dreval, M, Drewelow, P, Drews, P, Drummond, G, Duckworth, P, Dudding, H, Dumont, R, Dumortier, P, Dunai, D, Dunatov, T, Dunne, M, Durodie, F, Dux, R, Dvornova, A, Eastham, R, Edwards, J, Eich, T, Eichorn, A, Eidietis, N, Eksaeva, A, El Haroun, H, Ellwood, G, Elsmore, C, Embreus, O, Emery, S, Ericsson, G, Eriksson, B, Eriksson, F, Eriksson, J, Eriksson, L, Ertmer, S, Esquembri, S, Esquisabel, A, Estrada, T, Evans, G, Evans, S, Fable, E, Fagan, D, Faitsch, M, Falessi, M, Fanni, A, Farahani, A, Farquhar, I, Fasoli, A, Faugeras, B, Fazinic, S, Felici, F, Felton, R, Fernandes, A, Fernandes, H, Ferrand, J, Ferreira, D, Ferreira, J, Ferro, G, Fessey, J, Ficker, O, Field, A, Figueiredo, A, Figueiredo, J, Fil, A, Fil, N, Finburg, P, Fiorucci, D, Fischer, U, Fishpool, G, Fittill, L, Fitzgerald, M, Flammini, D, Flanagan, J, Flinders, K, Foley, S, Fonnesu, N, Fontana, M, Fontdecaba, J, Forbes, S, Formisano, A, Fornal, T, Fortuna, L, Fortuna-Zalesna, E, Fortune, M, Fowler, C, Fransson, E, Frassinetti, L, Freisinger, M, Fresa, R, Fridstrom, R, Frigione, D, Fulop, T, Furseman, M, Fusco, V, Futatani, S, Gadariya, D, Gal, K, Galassi, D, Galazka, K, Galeani, S, Gallart, D, Galvao, R, Gao, Y, Garcia, J, Garcia-Munoz, M, Gardener, M, Garzotti, L, Gaspar, J, Gatto, R, Gaudio, P, Gear, D, Gebhart, T, Gee, S, Gelfusa, M, George, R, Gerasimov, S, Gervasini, G, Gethins, M, Ghani, Z, Gherendi, M, Ghezzi, F, Giacalone, J, Giacomelli, L, Giacometti, G, Gibson, C, Gibson, K, Gil, L, Gillgren, A, Gin, D, Giovannozzi, E, Giroud, C, Glen, R, Gloggler, S, Goff, J, Gohil, P, Goloborodko, V, Gomes, R, Goncalves, B, Goniche, M, Goodyear, A, Gore, S, Gorini, G, Gorler, T, Gotts, N, Goulding, R, Gow, E, Graham, B, Graves, J, Greuner, H, Grierson, B, Griffiths, J, Griph, S, Grist, D, Gromelski, W, Groth, M, Grove, R, Gruca, M, Guard, D, Gupta, N, Gurl, C, Gusarov, A, Hackett, L, Hacquin, S, Hager, R, Hagg, L, Hakola, A, Halitovs, M, Hall, S, Hallworth-Cook, S, Ham, C, Hamaguchi, D, Hamed, M, Hamlyn-Harris, C, Hammond, K, Harford, E, Harrison, J, Harting, D, Hatano, Y, Hatch, D, Haupt, T, Hawes, J, Hawkes, N, Hawkins, J, Hayashi, T, Hazael, S, Hazel, S, Heesterman, P, Heidbrink, B, Helou, W, Hemming, O, Henderson, S, Henriques, R, Hepple, D, Herfindal, J, Hermon, G, Hill, J, Hillesheim, J, Hizanidis, K, Hjalmarsson, A, Ho, A, Hobirk, J, Hoenen, O, Hogben, C, Hollingsworth, A, Hollis, S, Hollmann, E, Holzl, M, Homan, B, Hook, M, Hopley, D, Horsley, D, Horsten, N, Horton, A, Horton, L, Horvath, L, Hotchin, S, Howell, R, Hu, Z, Huber, A, Huber, V, Huddleston, T, Huijsmans, G, Huynh, P, Hynes, A, Iliasova, M, Imrie, D, Imrisek, M, Ingleby, J, Innocente, P, Bjork, K, Isernia, N, Ivanova-Stanik, I, Ivings, E, Jablonski, S, Jachmich, S, Jackson, T, Jacquet, P, Jarleblad, H, Jaulmes, F, Rodriguez, J, Jepu, I, Joffrin, E, Johnson, R, Johnson, T, Johnston, J, Jones, C, Jones, G, Jones, L, Jones, N, Jones, T, Joyce, A, Juarez, R, Juvonen, M, Kaltiaisenaho, T, Kaniewski, J, Kantor, A, Kappatou, A, Karhunen, J, Karkinsky, D, Kashchuk, Y, Kaufman, M, Kaveney, G, Kazakov, Y, Kazantzidis, V, Keeling, D, Kelly, R, Kempenaars, M, Kennedy, C, Kennedy, D, Kent, J, Khan, K, Khilkevich, E, Kiefer, C, Kilpelainen, J, Kim, C, Kim, H, Kim, S, King, D, King, R, Kinna, D, Kiptily, V, Kirjasuo, A, Kirov, K, Kirschner, A, Kiviniemi, T, Kizane, G, Klas, M, Klepper, C, Klix, A, Kneale, G, Knight, M, Knight, P, Knights, R, Knipe, S, Knolker, M, Knott, S, Kocan, M, Kochl, F, Kodeli, I, Kolesnichenko, Y, Kominis, Y, Kong, M, Korovin, V, Kos, B, Kos, D, Koslowski, H, Kotschenreuther, M, Koubiti, M, Koziol, K, Krasilnikov, A, Krasilnikov, V, Kresina, M, Krieger, K, Krishnan, N, Krivska, A, Kruezi, U, Kukushkin, A, Kumpulainen, H, Kurki-Suonio, T, Kurotaki, H, Kwak, S, Kwon, O, Laguardia, L, Lagzdina, E, Lahtinen, A, Laing, A, Lam, N, Lambertz, H, Lane, B, Lane, C, Neto, E, Lawson, K, Lazaros, A, Lazzaro, E, Learoyd, G, Lee, C, Lee, S, Leerink, S, Leeson, T, Lefebvre, X, Leggate, H, Lehmann, J, Lehnen, M, Leichtle, D, Leipold, F, Lengar, I, Lennholm, M, Gutierrez, E, Lepiavko, B, Leppanen, J, Lerche, E, Lescinskis, A, Lewis, J, Leysen, W, Li, L, Li, Y, Likonen, J, Linsmeier, C, Lipschultz, B, Litaudon, X, Litherland-Smith, E, Liu, F, Loarer, T, Loarte, A, Lobel, R, Lomanowski, B, Lomas, P, Lopez, J, Lorenzini, R, Loreti, S, Losada, U, Loschiavo, V, Loughlin, M, Louka, Z, Lovell, J, Lowe, T, Lowry, C, Lubbad, S, Luce, T, Lucock, R, Lukin, A, Luna, C, de la Luna, E, Lungaroni, M, Lungu, C, Lunt, T, Lutsenko, V, Lyons, B, Lyssoivan, A, Machielsen, M, Macusova, E, Maenpaa, R, Maggi, C, Maggiora, R, Magness, M, Mahesan, S, Maier, H, Maingi, R, Malinowski, K, Manas, P, Mantica, P, Mantsinen, M, Manyer, J, Manzanares, A, Maquet, P, Marceca, G, Marcenko, N, Marchetto, C, Marchuk, O, Mariani, A, Mariano, G, Marin, M, Marinelli, M, Markovic, T, Marocco, D, Marot, L, Marsden, S, Marsh, J, Marshall, R, Martellucci, L, Martin, A, Martone, R, Maruyama, S, Maslov, M, Masuzaki, S, Matejcik, S, Mattei, M, Matthews, G, Matveev, D, Matveeva, E, Mauriya, A, Maviglia, F, Mayer, M, Mayoral, M, Mazzi, S, Mazzotta, C, Mcadams, R, Mccarthy, P, Mcclements, K, Mcclenaghan, J, Mccullen, P, Mcdonald, D, Mcguckin, D, Mchugh, D, Mcintyre, G, Mckean, R, Mckehon, J, Mcmillan, B, Mcnamee, L, Mcshee, A, Meakins, A, Medley, S, Meekes, C, Meghani, K, Meigs, A, Meisl, G, Meitner, S, Menmuir, S, Mergia, K, Merriman, S, Mertens, P, Meshchaninov, S, Messiaen, A, Michling, R, Middleton, P, Middleton-Gear, D, Mietelski, J, Milanesio, D, Milani, E, Militello, F, Asp, A, Milnes, J, Milocco, A, Miloshevsky, G, Minghao, C, Minucci, S, Miron, I, Miyamoto, M, Mlynar, J, Moiseenko, V, Monaghan, P, Monakhov, I, Moody, T, Moon, S, Mooney, R, Moradi, S, Morales, J, Morales, R, Mordijck, S, Moreira, L, Morgan, L, Moro, F, Morris, J, Morrison, K, Msero, L, Moulton, D, Mrowetz, T, Mundy, T, Muraglia, M, Murari, A, Muraro, A, Muthusonai, N, Na, Y, Nabais, F, Naden, M, Naish, J, Naish, R, Napoli, F, Nardon, E, Naulin, V, Nave, M, Nedzelskiy, I, Nemtsev, G, Nesenevich, V, Nestoras, I, Neu, R, Neverov, V, Ng, S, Nicassio, M, Nielsen, A, Nina, D, Nishijima, D, Noble, C, Nobs, C, Nocente, M, Nodwell, D, Nordlund, K, Nordman, H, Normanton, R, Noterdaeme, J, Nowak, S, Nunn, E, Nystrom, H, Oberparleiter, M, Obryk, B, O'Callaghan, J, Odupitan, T, Oliver, H, Olney, R, O'Mullane, M, Ongena, J, Organ, E, Orsitto, F, Orszagh, J, Osborne, T, Otin, R, Otsuka, T, Owen, A, Oya, Y, Oyaizu, M, Paccagnella, R, Pace, N, Packer, L, Paige, S, Pajuste, E, Palade, D, Pamela, S, Panadero, N, Panontin, E, Papadopoulos, A, Papp, G, Papp, P, Parail, V, Pardanaud, C, Parisi, J, Diaz, F, Parsloe, A, Parsons, M, Parsons, N, Passeri, M, Patel, A, Pau, A, Pautasso, G, Pavlichenko, R, Pavone, A, Pawelec, E, Soldan, C, Peacock, A, Pearce, M, Peluso, E, Penot, C, Pepperell, K, Pereira, R, Pereira, T, Cippo, E, Pereslavtsev, P, von Thun, C, Pericoli, V, Perry, D, Peterka, M, Petersson, P, Petravich, G, Petrella, N, Peyman, M, Pillon, M, Pinches, S, Pintsuk, G, de Sa, W, dos Reis, A, Piron, C, Pionr, L, Pironti, A, Pitts, R, van de Plassche, K, Platt, N, Plyusnin, V, Podesta, M, Pokol, G, Poli, F, Pompilian, O, Popovichev, S, Poradzinski, M, Porfiri, M, Porkolab, M, Porosnicu, C, Porton, M, Poulipoulis, G, Predebon, I, Prestopino, G, Price, C, Price, D, Price, M, Primetzhofer, D, Prior, P, Provatas, G, Pucella, G, Puglia, P, Purahoo, K, Pusztai, I, Putignano, O, Putterich, T, Quercia, A, Rachlew, E, Radulescu, G, Radulovic, V, Rainford, M, Raj, P, Ralph, G, Ramogida, G, Rasmussen, D, Rasmussen, J, Ratta, G, Ratynskaia, S, Rebai, M, Refy, D, Reichle, R, Reinke, M, Reiser, D, Reux, C, Reynolds, S, Richiusa, M, Richyal, S, Rigamonti, D, Rimini, F, Risner, J, Riva, M, Rivero-Rodriguez, J, Roach, C, Robins, R, Robinson, S, Robson, D, Rodionov, R, Rodrigues, P, Ramos, M, Rodriguez-Fernandez, P, Romanelli, F, Romanelli, M, Romanelli, S, Romazanov, J, Rossi, R, Rowe, S, Rowlands, D, Rubel, M, Rubinacci, G, Rubino, G, Ruchko, L, Ruiz, M, Ruiz, J, Ruset, C, Rzadkiewicz, J, Saarelma, S, Safi, E, Sahlberg, A, Salewski, M, Salmi, A, Salmon, R, Salzedas, F, Sanders, I, Sandiford, D, Santos, B, Santucci, A, Sarkimaki, K, Sarwar, R, Sarychev, I, Sauter, O, Sauwan, P, Scapin, N, Schluck, F, Schmid, K, Schmuck, S, Schneider, M, Schneider, P, Schworer, D, Scott, G, Scott, M, Scraggs, D, Scully, S, Segato, M, Seo, J, Sergienko, G, Sertoli, M, Sharapov, S, Shaw, A, Sheikh, H, Sheikh, U, Shepherd, A, Shevelev, A, Shigin, P, Shinohara, K, Shiraiwa, S, Shiraki, D, Short, M, Sias, G, Silburn, S, Silva, A, Silva, C, Silva, J, Silvagni, D, Simfukwe, D, Simpson, J, Sinclair, D, Sipila, S, Sips, A, Siren, P, Sirinelli, A, Sjostrand, H, Skinner, N, Slater, J, Smith, N, Smith, P, Snell, J, Snoep, G, Snoj, L, Snyder, P, Soare, S, Solano, E, Solokha, V, Somers, A, Sommariva, C, Soni, K, Sorokovoy, E, Sos, M, Sousa, J, Sozzi, C, Spagnolo, S, Spelzini, T, Spineanu, F, Spong, D, Sprada, D, Sridhar, S, Srinivasan, C, Stables, G, Staebler, G, Stamatelatos, I, Stancar, Z, Staniec, P, Stankunas, G, Stead, M, Stefanikova, E, Stephen, A, Stephens, J, Stevenson, P, Stojanov, M, Strand, P, Strauss, H, Strikwerda, S, Strom, P, Stuart, C, Studholme, W, Subramani, M, Suchkov, E, Sumida, S, Sun, H, Susts, T, Svensson, J, Svoboda, J, Sweeney, R, Sytnykov, D, Szabolics, T, Szepesi, G, Tabia, B, Tadic, T, Tal, B, Tala, T, Tallargio, A, Tamain, P, Tan, H, Tanaka, K, Tang, W, Tardocchi, M, Taylor, D, Teimane, A, Telesca, G, Teplova, N, Teplukhina, A, Terentyev, D, Terra, A, Terranova, D, Terranova, N, Testa, D, Tholerus, E, Thomas, J, Thoren, E, Thorman, A, Tierens, W, Tinguely, R, Tipton, A, Todd, H, Tokitani, M, Tolias, P, Tomes, M, Tookey, A, Torikai, Y, von Toussaint, U, Tsavalas, P, Tskhakaya, D, Turner, I, Turner, M, Turnyanskiy, M, Tvalashvili, G, Tyrrell, S, Tyshchenko, M, Uccello, A, Udintsev, V, Urbanczyk, G, Vadgama, A, Valcarcel, D, Valisa, M, Olivares, P, Vallhagen, O, Van Eester, D, Varje, J, Vartanian, S, Vasilopoulou, T, Vayakis, G, Vecsei, M, Vega, J, Ventre, S, Verdoolaege, G, Verona, C, Rinati, G, Veshchev, E, Vianello, N, Viezzer, E, Vignitchouk, L, Vila, R, Villari, R, Villone, F, Vincenzi, P, Vinyar, I, Viola, B, Virtanen, A, Vitins, A, Vizvary, Z, Vlad, G, Vlad, M, Vondracek, P, de Vries, P, Wakeling, B, Walkden, N, Walker, M, Walker, R, Walsh, M, Wang, E, Wang, N, Warder, S, Warren, R, Waterhouse, J, Watts, C, Wauters, T, Weckmann, A, Maxwell, H, Weiland, M, Weisen, H, Weiszflog, M, Welch, P, Wendler, N, West, A, Wheatley, M, Wheeler, S, Whitehead, A, Whittaker, D, Widdowson, A, Wiesen, S, Wilkinson, J, Williams, J, Willoughby, D, Wilson, I, Wilson, J, Wilson, T, Wischmeier, M, Wise, P, Withenshaw, G, Withycombe, A, Witts, D, Wojcik-Gargula, A, Wolfrum, E, Wood, R, Woodley, C, Woodley, R, Woods, B, Wright, J, Xu, T, Yadikin, D, Yajima, M, Yakovenko, Y, Yang, Y, Yanling, W, Yanovskiy, V, Young, I, Young, R, Zabolockis, R, Zacks, J, Zagorski, R, Zaitsev, F, Zakharov, L, Zarins, A, Fernandez, D, Zastrow, K, Zayachuk, Y, Zerbini, M, Zhang, W, Zhou, Y, Zlobinski, M, Zocco, A, Zohar, A, Zoita, V, Zoletnik, S, Zotta, V, Zoulias, I, Zwingmann, W, Zychor, I, Alekseev, AG, Sunden, EA, Angelini, BM, Appel, LC, Bandaru, VK, Baranov, YF, Beaumont, PS, Bizarro, JPS, Mihalic, IB, Bradnam, SC, Carvalho, IS, Casson, FJ, Catalan, JP, Challis, CD, Chang, CS, Coad, JP, Coenen, JW, Coffey, IH, Conway, NJ, Esposito, MC, Day, IE, Dendy, RO, Doerner, RP, Donne, AJH, Eriksson, LG, Esquisabel, AL, Ferreira, DR, Field, AR, Fontdecaba, JM, Gerasimov, SN, Giacalone, JC, Gibson, KJ, Graves, JP, Hall, SA, Ham, CJ, Harrison, JR, Hatch, DR, Hawkes, NC, Henderson, SS, Henriques, RB, Hillesheim, JC, Horton, LD, Huijsmans, GTA, Bjork, KI, Rodriguez, JJ, Kazakov, YO, Keeling, DL, Kim, HT, Kim, SH, King, DB, Kiptily, VG, Kirov, KK, Koslowski, HR, Kukushkin, AB, Kwon, OJ, Lambertz, HT, Neto, EL, Lawson, KD, Lee, SE, Leggate, HJ, Gutierrez, EL, Lomas, PJ, Lopez, JM, Loschiavo, VP, Lungu, CP, Maggi, CF, Mantsinen, MJ, Martin, AJ, Matthews, GF, Mayoral, ML, McAdams, R, McCarthy, PJ, McClements, KG, McClenaghan, J, McCullen, P, McDonald, DC, McGuckin, D, McHugh, D, McIntyre, G, McKean, R, McKehon, J, McMillan, B, McNamee, L, McShee, A, Meekes, CJ, Meigs, AG, Asp, AM, Morales, RB, Morrison, KM, Na, YS, Nave, MFF, Neverov, VS, Nielsen, AH, Nobs, CR, Noterdaeme, JM, Oliver, HJC, Packer, LW, Pamela, SJP, Parail, VV, Diaz, FP, Soldan, CP, Cippo, EP, von Thun, CP, de Sa, WP, dos Reis, AP, van de Plassche, KL, Poli, FM, Pompilian, OG, Porfiri, MT, Rasmussen, JJ, Richiusa, ML, Rimini, FG, Roach, CM, Ramos, MR, Ruiz, JR, Schneider, PA, Sharapov, SE, Silburn, SA, Sipila, SK, Sips, ACC, Solano, ER, Strauss, HR, Stuart, CI, Sun, HJ, Susts, TE, Teimane, AS, Tinguely, RA, Turner, MM, Olivares, PV, Rinati, GV, Virtanen, AJ, Walkden, NR, Maxwell, HW, Williams, JC, Wright, JC, Zabolockis, RJ, Zaitsev, FS, Fernandez, DZ, Zastrow, KD, Zotta, VK, Mailloux, J, Abid, N, Abraham, K, Abreu, P, Adabonyan, O, Adrich, P, Afanasev, V, Afzal, M, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Akhtar, M, Albanese, R, Alderson-Martin, M, Alegre, D, Aleiferis, S, Aleksa, A, Alekseev, A, Alessi, E, Aleynikov, P, Algualcil, J, Ali, M, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amosov, V, Sunden, E, Andrew, P, Angelini, B, Angioni, C, Antoniou, I, Appel, L, Appelbee, C, Aria, S, Ariola, M, Artaserse, G, Arter, W, Artigues, V, Asakura, N, Ash, A, Ashikawa, N, Aslanyan, V, Astrain, M, Asztalos, O, Auld, D, Auriemma, F, Austin, Y, Avotina, L, Aymerich, E, Baciero, A, Bairaktaris, F, Balbin, J, Balbinot, L, Balboa, I, Balden, M, Balshaw, C, Balshaw, N, Bandaru, V, Banks, J, Baranov, Y, 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Donne, AJH, Eriksson, LG, Esquisabel, AL, Ferreira, DR, Field, AR, Fontdecaba, JM, Gerasimov, SN, Giacalone, JC, Gibson, KJ, Graves, JP, Hall, SA, Ham, CJ, Harrison, JR, Hatch, DR, Hawkes, NC, Henderson, SS, Henriques, RB, Hillesheim, JC, Horton, LD, Huijsmans, GTA, Bjork, KI, Rodriguez, JJ, Kazakov, YO, Keeling, DL, Kim, HT, Kim, SH, King, DB, Kiptily, VG, Kirov, KK, Koslowski, HR, Kukushkin, AB, Kwon, OJ, Lambertz, HT, Neto, EL, Lawson, KD, Lee, SE, Leggate, HJ, Gutierrez, EL, Lomas, PJ, Lopez, JM, Loschiavo, VP, Lungu, CP, Maggi, CF, Mantsinen, MJ, Martin, AJ, Matthews, GF, Mayoral, ML, McAdams, R, McCarthy, PJ, McClements, KG, McClenaghan, J, McCullen, P, McDonald, DC, McGuckin, D, McHugh, D, McIntyre, G, McKean, R, McKehon, J, McMillan, B, McNamee, L, McShee, A, Meekes, CJ, Meigs, AG, Asp, AM, Morales, RB, Morrison, KM, Na, YS, Nave, MFF, Neverov, VS, Nielsen, AH, Nobs, CR, Noterdaeme, JM, Oliver, HJC, Packer, LW, Pamela, SJP, Parail, VV, Diaz, FP, Soldan, CP, Cippo, EP, von Thun, CP, de Sa, WP, dos Reis, AP, van de Plassche, KL, Poli, FM, Pompilian, OG, Porfiri, MT, Rasmussen, JJ, Richiusa, ML, Rimini, FG, Roach, CM, Ramos, MR, Ruiz, JR, Schneider, PA, Sharapov, SE, Silburn, SA, Sipila, SK, Sips, ACC, Solano, ER, Strauss, HR, Stuart, CI, Sun, HJ, Susts, TE, Teimane, AS, Tinguely, RA, Turner, MM, Olivares, PV, Rinati, GV, Virtanen, AJ, Walkden, NR, Maxwell, HW, Williams, JC, Wright, JC, Zabolockis, RJ, Zaitsev, FS, Fernandez, DZ, Zastrow, KD, and Zotta, VK
Abstract: The JET 2019-2020 scientific and technological programme exploited the results of years of concerted scientific and engineering work, including the ITER-like wall (ILW: Be wall and W divertor) installed in 2010, improved diagnostic capabilities now fully available, a major neutral beam injection upgrade providing record power in 2019-2020, and tested the technical and procedural preparation for safe operation with tritium. Research along three complementary axes yielded a wealth of new results. Firstly, the JET plasma programme delivered scenarios suitable for high fusion power and alpha particle (alpha) physics in the coming D-T campaign (DTE2), with record sustained neutron rates, as well as plasmas for clarifying the impact of isotope mass on plasma core, edge and plasma-wall interactions, and for ITER pre-fusion power operation. The efficacy of the newly installed shattered pellet injector for mitigating disruption forces and runaway electrons was demonstrated. Secondly, research on the consequences of long-term exposure to JET-ILW plasma was completed, with emphasis on wall damage and fuel retention, and with analyses of wall materials and dust particles that will help validate assumptions and codes for design and operation of ITER and DEMO. Thirdly, the nuclear technology programme aiming to deliver maximum technological return from operations in D, T and D-T benefited from the highest D-D neutron yield in years, securing results for validating radiation transport and activation codes, and nuclear data for ITER.
Published: 2022

2. First principles and integrated modelling achievements towards trustful fusion power predictions for JET and ITER

Author: Garcia, J., Dumont, R. J., Joly, J., Morales, J., Garzotti, L., Bache, T. W., Baranov, Y., Casson, F. J., Challis, C., Kirov, K., Mailloux, J., Saarelma, S., Nocente, M., Banon-Navarro, A., Goerler, T., Citrin, J., Ho, A., Gallart, D., Mantsinen, M., Abduallev, (Abduallev, S, ( 8, S., 42, ), Abhangi, (Abhangi, M, ( 8, M., 54, ), Abreu, (Abreu, P, ( 8, P., 60, ), Afanasev, (Afanasev, V, V)(, 8, 61, ), Afzal, (Afzal, M, 14, ), Aggarwal, (Aggarwal, Km, ( 8, K. M., 85, ), Ahlgren, (Ahlgren, T, ( 8, T., 106, ), Aho-Mantila, (Aho-Mantila, L, ( 8, L., 113, ), Aiba, (Aiba, N, ( 8, N., 73, ), Airila, (Airila, M, Alarcon, (Alarcon, T, 15, ), Albanese, (Albanese, R, ( 8, R., 18, ), Alegre, (Alegre, D, ( 8, D., 64, ), Aleiferis, (Aleiferis, S, 75, ), Alessi, (Alessi, E, ( 8, E., 50, ), Aleynikov, (Aleynikov, P, 62, ), Alkseev, (Alkseev, A, ( 8, A., 76, ), Allinson, (Allinson, M, Alper, (Alper, B, ( 8, B., Alves, (Alves, E, Ambrosino, (Ambrosino, G, ( 8, G., (Ambrosino, R, Amosov, (Amosov, V, 95, ), Sunden, (Sunden, Ea, Andersson)( 8, E., 26, ), Andrews, (Andrews, R, Angelone, (Angelone, M, 96, ), Anghel, (Anghel, M, 92, ), Angioni, (Angioni, C, ( 8, C., 68, ), Appel, (Appel, L, Appelbee, (Appelbee, C, Arena, Paolo Pietro, (Arena, P, 34, ), Ariola, (Ariola, M, Arshad, (Arshad, S, 45, ), Artaud, (Artaud, J, ( 8, J., Arter, (Arter, W, ( 8, W., Ash, (Ash, A, Ashikawa, (Ashikawa, N, ( 8 ), N., Aslanyan, (Aslanyan, V, 70, ), Asunta, (Asunta, O, ( 8, O., Asztalos, 9, (Asztalos, O, 114, ), Auriemma, (Auriemma, F, ( 8, F., 19, ), Austin, (Austin, Y, ( 8, Y., Avotina, (Avotina, L, 109, ), Axton, (Axton, M, Ayres, (Ayres, C, Baciero, (Baciero, A, Baiao, (Baiao, D, Balboa, (Balboa, I, I)(, 8, Balden, (Balden, M, Balshaw, (Balshaw, N, Bandaru, (Bandaru, Vk, ( 8, V. 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J., Varje, (Varje, J, Vartanian, 9, (Vartanian, S, Vasava, (Vasava, K, Vasilopoulou, (Vasilopoulou, T, Vecsei, (Vecsei, M, Vega, (Vega, J, Ventre, (Ventre, S, Verdoolaege, (Verdoolaege, G, Verona, (Verona, C, Rinati, (Rinati, Gv, Verona)( 8, G., Veshchev, (Veshchev, E, Vianello, (Vianello, N, Vicente, (Vicente, J, Viezzer, (Viezzer, E, Villari, (Villari, S, Villone, (Villone, F, Vincent, (Vincent, M, Vincenzi, (Vincenzi, P, Vinyar, (Vinyar, I, Viola, (Viola, B, Vitins, (Vitins, A, Vizvary, (Vizvary, Z, Vlad, (Vlad, M, Voitsekhovitch, (Voitsekhovitch, I, Voltolina, (Voltolina, D, Von, Toussaint, U (von Toussaint, Vondracek, (Vondracek, P, Vuksic, (Vuksic, M, Wakeling, (Wakeling, B, Waldon, (Waldon, C, Walkden, (Walkden, N, Walker, (Walker, R, (Walker, M, Walsh, (Walsh, M, Wang, (Wang, N, (Wang, E, Warder, (Warder, S, Warren, (Warren, R, Waterhouse, (Waterhouse, J, Watts, (Watts, C, Wauters, (Wauters, T, Webb, (Webb, M, Weckmann, (Weckmann, A, Weiland, (Weiland, J, (Weiland, M, Weisen, (Weisen, H, Weiszflog, (Weiszflog, M, Welch, (Welch, P, West, (West, A, Wheatley, (Wheatley, M, Wheeler, (Wheeler, S, Whitehead, (Whitehead, Am, Whittaker, (Whittaker, D, Widdowson, (Widdowson, Am, Wiesen, (Wiesen, S, Wilkie, (Wilkie, G, Williams, (Williams, J, Willoughby, (Willoughby, D, Wilson, (Wilson, J, (Wilson, I, (Wilson, Hr, Wischmeier, (Wischmeier, M, Withycombe, (Withycombe, A, Witts, (Witts, D, Wolfrum, (Wolfrum, E, Wood, (Wood, R, Woodley, (Woodley, R, (Woodley, C, Wray, (Wray, S, Wright, (Wright, Jc, (Wright, P, Wukitch, (Wukitch, S, Wynn, (Wynn, A, Xiang, (Xiang, L, (Xu, T, Xue, (Xue, Y, Yadikin, (Yadikin, D, Yakovenko, (Yakovenko, Y, Yanling, (Yanling, W, Yavorskij, (Yavorskij, V, Young, (Young, I, (Young, R, (Young, D, Zacks, (Zacks, J, Zagorski, (Zagorski, R, Zaitsev, (Zaitsev, Fs, ( 8, F. S., Zakharov, (Zakharov, L, Zanino, (Zanino, R, Zarins, (Zarins, A, (Zarins, R, Fernandez, (Fernandez, Dz, Zarzoso)( 8, D., Zastrow, (Zastrow, Kd, Zerbini, (Zerbini, M, Zhang, (Zhang, W, Zhou, (Zhou, Y, Zilli, (Zilli, E, Zocco, (Zocco, A, Zoita, (Zoita, V, Zoletnik, (Zoletnik, S, Zwingmann, (Zwingmann, W, Zychor, (Zychor, I, 71), Science and Technology of Nuclear Fusion, Garcia, J, Dumont, R, Joly, J, Morales, J, Garzotti, L, Bache, T, Baranov, Y, Casson, F, Challis, C, Kirov, K, Mailloux, J, Saarelma, S, Nocente, M, Banon-Navarro, A, Goerler, T, Citrin, J, Ho, A, Gallart, D, Mantsinen, M, Mariani, A, Garcia, J., Dumont, R. J., Joly, J., Morales, J., Garzotti, L., Bache, T. W., Baranov, Y., Casson, F. J., Challis, C., Kirov, K., Mailloux, J., Saarelma, S., Nocente, M., Banon-Navarro, A., Goerler, T., Citrin, J., Ho, A., Gallart, D., Formisano, A., Mantsinen, M., Dumont, Rj, Bache, Tw, Casson, Fj, Abduallev, S, Abhangi, M, Abreu, P, Afanasev, V, Afzal, M, Aggarwal, Km, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Alarcon, T, Albanese, R, Alegre, D, Aleiferis, S, Alessi, E, Aleynikov, P, Alkseev, A, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amosov, V, Sunden, Ea, Andrews, R, Angelone, M, Anghel, M, Angioni, C, Appel, L, Appelbee, C, Arena, P, Ariola, M, Arshad, S, Artaud, J, Arter, W, Ash, A, Ashikawa, N, Aslanyan, V, Asunta, O, Asztalos, O, Auriemma, F, Austin, Y, Avotina, L, Axton, M, Ayres, C, Baciero, A, Baiao, D, Balboa, I, Balden, M, Balshaw, N, Bandaru, Vk, Banks, J, Baranov, Yf, Barcellona, C, Barnard, T, Barnes, M, Barnsley, R, Wiechec, Ab, Orte, Lb, Baruzzo, M, Basiuk, V, Bassan, M, Bastow, R, Batista, A, Batistoni, P, Baumane, L, Bauvir, B, Baylor, L, Beaumont, P, Beckers, M, Beckett, B, Bekris, N, Beldishevski, M, Bell, K, Belli, F, Belonohy, E, Benayas, J, Bergsaker, H, Bernardo, J, Bernert, M, Berry, M, Bertalot, L, Besiliu, C, Betar, H, Beurskens, M, Bielecki, J, Biewer, T, Bilato, R, Biletskyi, O, Bilkova, P, Binda, F, Birkenmeier, G, Bizarro, Jp, Bjorkas, C, Blackburn, J, Blackman, Tr, Blanchard, P, Blatchford, P, Bobkov, V, Boboc, A, Bogar, O, Bohm, P, Bohm, T, Bolshakova, I, Bolzonella, T, Bonanomi, N, Boncagni, L, Bonfiglio, D, Bonnin, X, Boom, J, Borba, D, Borodin, D, Borodkina, I, Boulbe, C, Bourdelle, C, Bowden, M, Bowman, C, Boyce, T, Boyer, H, Bradnam, Sc, Braic, V, Bravanec, R, Breizman, B, Brennan, D, Breton, S, Brett, A, Brezinsek, S, Bright, M, Brix, M, Broeckx, W, Brombin, M, Broslawski, A, Brown, B, Brunetti, D, Bruno, E, Buch, J, Buchanan, J, Buckingham, R, Buckley, M, Bucolo, M, Budny, R, Bufferand, H, Buller, S, Bunting, P, Buratti, P, Burckhart, A, Burroughes, G, Buscarino, A, Busse, A, Butcher, D, Butler, B, Bykov, I, Cahyna, P, Calabro, G, Calacci, L, Callaghan, D, Callaghan, J, Calvo, I, Camenen, Y, Camp, P, Campling, Dc, Cannas, B, Capat, A, Carcangiu, S, Card, P, Cardinali, A, Carman, P, Carnevale, D, Carr, M, Carralero, D, Carraro, L, Carvalho, Bb, Carvalho, I, Carvalho, P, Carvalho, Dd, Castaldo, C, Catarino, N, Causa, F, Cavazzana, R, Cave-Ayland, K, Cavedon, M, Cecconello, M, Ceccuzzi, S, Cecil, E, Challis, Cd, Chandra, D, Chang, C, Chankin, A, Chapman, It, Chapman, B, Chapman, Sc, Chernyshova, M, Chiariello, A, Chitarin, G, Chmielewski, P, Chone, L, Ciraolo, G, Ciric, D, Clairet, F, Clark, M, Clark, E, Clarkson, R, Clay, R, Clements, C, Coad, Jp, Coates, P, Cobalt, A, Coccorese, V, Cocilovo, V, Coelho, R, Coenen, Jw, Coffey, I, Colas, L, Colling, B, Collins, S, Conka, D, Conroy, S, Conway, N, Coombs, D, Cooper, Sr, Corradino, C, Corre, Y, Corrigan, G, Coster, D, Craciunescu, T, Cramp, S, Crapper, C, Crisanti, F, Croci, G, Croft, D, Crombe, K, Cruz, N, Cseh, G, Cufar, A, Cullen, A, Curson, P, Curuia, M, Czarnecka, A, Czarski, T, Cziegler, I, Dabirikhah, H, Dal Molin, A, Dalgliesh, P, Dalley, S, Dankowski, J, Darrow, D, David, P, Davies, A, Davis, W, Dawson, K, Day, I, Day, C, De Bock, M, de Castro, A, De Dominici, G, de la Cal, E, de la Luna, E, De Masi, G, De Temmerman, G, De Tommasi, G, de Vries, P, Deane, J, Dejarnac, R, Del Sarto, D, Delabie, E, Demerdzhiev, V, Dempsey, A, den Harder, N, Dendy, Ro, Denis, J, Denner, P, Devaux, S, Devynck, P, Di Maio, F, Di Siena, A, Di Troia, C, Dickinson, D, Dinca, P, Dittmar, T, Dobrashian, J, Doerk, H, Doerner, Rp, Domptail, F, Donne, T, Dorling, Se, Douai, D, Dowson, S, Drenik, A, Dreval, M, Drewelow, P, Drews, P, Duckworth, P, Dumortier, P, Dunai, D, Dunne, M, Duran, I, Durodie, F, Dutta, P, Duval, Bp, Dux, R, Dylst, K, Edappala, Pv, Edwards, Am, Edwards, J, Eich, T, Eidietis, N, Eksaeva, A, Ellis, R, Ellwood, G, Elsmore, C, Emery, S, Enachescu, M, Ericsson, G, Eriksson, J, Eriksson, F, Eriksson, Lg, Ertmer, S, Esquembri, S, Esquisabel, Al, Esser, Hg, Ewart, G, Fable, E, Fagan, D, Faitsch, M, Falie, D, Fanni, A, Farahani, A, Fasoli, A, Faugeras, B, Fazinic, S, Felici, F, Felton, Rc, Feng, S, Fernades, A, Fernandes, H, Ferreira, J, Ferreira, Dr, Ferro, G, Fessey, Ja, Ficker, O, Field, A, Fietz, S, Figini, L, Figueiredo, J, Figueiredo, A, Fil, N, Finburg, P, Fischer, U, Fittill, L, Fitzgerald, M, Flammini, D, Flanagan, J, Flinders, K, Foley, S, Fonnesu, N, Fontdecaba, Jm, Formisano, A, Forsythe, L, Fortuna, L, Fransson, E, Frasca, M, Frassinetti, L, Freisinger, M, Fresa, R, Fridstrom, R, Frigione, D, Fuchs, V, Fusco, V, Futatani, S, Gal, K, Galassi, D, Galazka, K, Galeani, S, Galvao, R, Gao, Y, Garcia-Carrasco, A, Garcia-Munoz, M, Gardener, M, Gaspar, J, Gaudio, P, Gear, D, Gebhart, T, Gee, S, Geiger, B, Gelfusa, M, George, R, Gerasimov, S, Gervasini, G, Gethins, M, Ghani, Z, Ghate, M, Gherendi, M, Ghezzi, F, Giacalone, Jc, Giacomelli, L, Giacometti, G, Gibson, K, Giegerich, T, Gil, L, Gilbert, Mr, Gin, D, Giovannozzi, E, Giroud, C, Gloggler, S, Goff, J, Gohil, P, Goloborod'Ko, V, Gomes, R, Goncalves, B, Goniche, M, Goodyear, A, Gorini, G, Gorler, T, Goulding, R, Goussarov, A, Graham, B, Graves, Jp, Greuner, H, Grierson, B, Griffiths, J, Griph, S, Grist, D, Groth, M, Grove, R, Gruca, M, Guard, D, Guerard, C, Guillemaut, C, Guirlet, R, Gulati, S, Gurl, C, Gutierrez-Milla, A, Utoh, Hh, Hackett, L, Hacquin, S, Hager, R, Hakola, A, Halitovs, M, Hall, S, Hallworth-Cook, S, Ham, C, Hamed, M, Hamilton, N, Hamlyn-Harris, C, Hammond, K, Hancu, G, Harrison, J, Harting, D, Hasenbeck, F, Hatano, Y, Hatch, Dr, Haupt, T, Hawes, J, Hawkes, Nc, Hawkins, J, Hawkins, P, Hazel, S, Heesterman, P, Heinola, K, Hellesen, C, Hellsten, T, Helou, W, Hemming, O, Hender, Tc, Henderson, S, Henderson, M, Henriques, R, Hepple, D, Herfindal, J, Hermon, G, Hidalgo, C, Higginson, W, Highcock, Eg, Hillesheim, J, Hillis, D, Hizanidis, K, Hjalmarsson, A, Hobirk, J, Hogben, Cha, Hogeweij, Gmd, Hollingsworth, A, Hollis, S, Holzl, M, Honore, Jj, Hook, M, Hopley, D, Horacek, J, Hornung, G, Horton, A, Horton, Ld, Horvath, L, Hotchin, Sp, Howell, R, Hubbard, A, Huber, A, Huber, V, Huddleston, Tm, Hughes, M, Hughes, J, Huijsmans, Gta, Huynh, P, Hynes, A, Igaune, I, Iglesias, D, Imazawa, N, Imrisek, M, Incelli, M, Innocente, P, Ivanova-Stanik, I, Ivings, E, Jachmich, S, Jackson, A, Jackson, T, Jacquet, P, Jansons, J, Jaulmes, F, Jednorog, S, Jenkins, I, Jepu, I, Johnson, T, Johnson, R, Johnston, J, Joita, L, Jonasson, E, Jones, T, Jones, C, Jones, L, Jones, G, Jones, N, Juvonen, M, Hoshino, Kk, Kallenbach, A, Kalsey, M, Kaltiaisenaho, T, Kamiya, K, Kaniewski, J, Kantor, A, Kappatou, A, Karhunen, J, Karkinsky, D, Kaufman, M, Kaveney, G, Kazakov, Y, Kazantzidis, V, Keeling, Dl, Keenan, Fp, Kempenaars, M, Kent, O, Kent, J, Keogh, K, Khilkevich, E, Kim, Ht, King, R, King, D, Kinna, Dj, Kiptily, V, Kirk, A, Kirschner, A, Kizane, G, Klas, M, Klepper, C, Klix, A, Knight, M, Knight, P, Knipe, S, Knott, S, Kobuchi, T, Kochl, F, Kocsis, G, Kodeli, I, Koechl, F, Kogut, D, Koivuranta, S, Kolesnichenko, Y, Kollo, Z, Kominis, Y, Koppen, M, Korolczuk, S, Kos, B, Koslowski, Hr, Kotschenreuther, M, Koubiti, M, Kovaldins, R, Kovanda, O, Kowalska-Strzeciwilk, E, Krasilnikov, A, Krasilnikov, V, Krawczyk, N, Kresina, M, Krieger, K, Krivska, A, Kruezi, U, Ksiazek, I, Kukushkin, A, Kundu, A, Kurki-Suonio, T, Kwak, S, Kwon, Oj, Laguardia, L, Lahtinen, A, Laing, A, Lalousis, P, Lam, N, Lamb, C, Lambertz, Ht, Lang, Pt, Lanthaler, S, Neto, El, Laszynska, E, Lawless, R, Lawson, Kd, Lazaros, A, Lazzaro, E, Leach, R, Learoyd, G, Leerink, S, Lefebvre, X, Leggate, Hj, Lehmann, J, Lehnen, M, Leichauer, P, Leichtle, D, Leipold, F, Lengar, I, Lennholm, M, Lepiavko, B, Leppanen, J, Lerche, E, Lescinskis, A, Lescinskis, B, Lesnoj, S, Leyland, M, Leysen, W, Li, Y, Li, L, Liang, Y, Likonen, J, Linke, J, Linsmeier, C, Lipschultz, B, Litaudon, X, Liu, G, Lloyd, B, Lo Schiavo, Vp, Loarer, T, Loarte, A, Lomanowski, B, Lomas, Pj, Lonnroth, J, Lopez, Jm, Lorenzini, R, Losada, U, Loughlin, M, Lowry, C, Luce, T, Lucock, R, Lukin, A, Luna, C, Lungaroni, M, Lungu, Cp, Lungu, M, Lunniss, A, Lunt, T, Lupelli, I, Lutsenko, V, Lyssoivan, A, Macheta, P, Macusova, E, Magesh, B, Maggi, C, Maggiora, R, Mahesan, S, Maier, H, Maingi, R, Makwana, R, Malaquias, A, Malinowski, K, Malizia, A, Manas, P, Manduchi, G, Manso, Me, Mantica, P, Manzanares, A, Maquet, P, Marandet, Y, Marcenko, N, Marchetto, C, Marchuk, O, Marconato, N, Marin, M, Marinelli, M, Marinucci, M, Markovic, T, Marocco, D, Marot, L, Marsh, J, Martin, A, de Aguilera, Am, Martin-Solis, Jr, Martone, R, Martynova, Y, Maruyama, S, Maslov, M, Matejcik, S, Mattei, M, Matthews, Gf, Matveev, D, Matveeva, E, Mauriya, A, Maviglia, F, May-Smith, T, Mayer, M, Mayoral, Ml, Mazon, D, Mazzotta, C, Mcadams, R, Mccarthy, Pj, Mcclements, Kg, Mccormack, O, Mccullen, Pa, Mcdonald, D, Mchardy, M, Mckean, R, Mckehon, J, Mcnamee, L, Meadowcroft, C, Meakins, A, Medley, S, Meigh, S, Meigs, Ag, Meisl, G, Meiter, S, Meitner, S, Meneses, L, Menmuir, S, Mergia, K, Merle, A, Merriman, P, Mertens, P, Meshchaninov, S, Messiaen, A, Meyer, H, Michling, R, Milanesio, D, Militello, F, Militello-Asp, E, Milocco, A, Miloshevsky, G, Mink, F, Minucci, S, Miron, I, Mistry, S, Miyoshi, Y, Mlynar, J, Moiseenko, V, Monaghan, P, Monakhov, I, Moon, S, Mooney, R, Moradi, S, Moran, J, Mordijck, S, Moreira, L, Moro, F, Morris, J, Moser, L, Mosher, S, Moulton, D, Mrowetz, T, Muir, A, Muraglia, M, Murari, A, Muraro, A, Murphy, S, Muscat, P, Muthusonai, N, Myers, C, Asakura, Nn, N'Konga, B, Nabais, F, Naish, R, Naish, J, Nakano, T, Napoli, F, Nardon, E, Naulin, V, Nave, Mff, Nedzelskiy, I, Nemtsev, G, Nesenevich, V, Nespoli, F, Neto, A, Neu, R, Neverov, V, Newman, M, Ng, S, Nicassio, M, Nielsen, Ah, Nina, D, Nishijima, D, Noble, C, Nobs, Cr, Nodwell, D, Nordlund, K, Nordman, H, Normanton, R, Noterdaeme, Jm, Nowak, S, Nunes, I, O'Gorman, T, O'Mullane, M, Oberkofler, M, Oberparleiter, M, Odupitan, T, Ogawa, Mt, Okabayashi, M, Oliver, H, Olney, R, Omoregie, L, Ongena, J, Orsitto, F, Orszagh, J, Osborne, T, Otin, R, Owen, A, Owen, T, Paccagnella, R, Packer, Lw, Pajuste, E, Pamela, S, Panja, S, Papp, P, Papp, G, Parail, V, Pardanaud, C, Diaz, Fp, Parsloe, A, Parsons, N, Parsons, M, Pasqualotto, R, Passeri, M, Patel, A, Pathak, S, Patten, H, Pau, A, Pautasso, G, Pavlichenko, R, Pavone, A, Pawelec, E, Soldan, Cp, Peackoc, A, Pehkonen, Sp, Peluso, E, Penot, C, Penzo, J, Pepperell, K, Pereira, R, Cippo, Ep, von Thun, Cp, Pericoli, V, Peruzzo, S, Peterka, M, Petersson, P, Petravich, G, Petre, A, Petrzilka, V, Philipps, V, Pigatto, L, Pillon, M, Pinches, S, Pintsuk, G, Piovesan, P, de Sa, Wp, dos Reis, Ap, Piron, L, Piron, C, Pironti, A, Pisano, F, Pitts, R, Plyusnin, V, Poli, Fm, Pomaro, N, Pompilian, Og, Pool, P, Popovichev, S, Poradzinski, M, Porfiri, Mt, Porosnicu, C, Porton, M, Possnert, G, Potzel, S, Poulipoulis, G, Powell, T, Prajapati, V, Prakash, R, Predebon, I, Prestopino, G, Price, D, Price, M, Price, R, Primetzhofer, D, Prior, P, Pucella, G, Puglia, P, Puiatti, Me, Purahoo, K, Pusztai, I, Putterich, T, Rachlew, E, Rack, M, Ragona, R, Rainford, M, Raj, P, Rakha, A, Ramogida, G, Ranjan, S, Rapson, Cj, Rasmussen, D, Rasmussen, Jj, Rathod, K, Ratta, G, Ratynskaia, S, Ravera, G, Rebai, M, Reed, A, Refy, D, Regana, J, Reich, M, Reid, N, Reimold, F, Reinhart, M, Reinke, M, Reiser, D, Rendell, D, Reux, C, Cortes, Sdar, Reynolds, S, Ricci, D, Richiusa, M, Rigamonti, D, Rimini, Fg, Risner, J, Riva, M, Rivero-Rodriguez, J, Roach, C, Robins, R, Robinson, S, Robson, D, Rodionov, R, Rodrigues, P, Rodriguez, J, Rohde, V, Romanelli, M, Romanelli, F, Romanelli, S, Romazanov, J, Rowe, S, Rubel, M, Rubinacci, G, Rubino, G, Ruchko, L, Ruset, C, Rzadkiewicz, J, Sabot, R, Saez, X, Safi, E, Sahlberg, A, Saibene, G, Saleem, M, Salewski, M, Salmi, A, Salmon, R, Salzedas, F, Samm, U, Sandiford, D, Santa, P, Santala, Mik, Santos, B, Santucci, A, Sartori, F, Sartori, R, Sauter, O, Scannell, R, Schluck, F, Schlummer, T, Schmid, K, Schmuck, S, Schopf, K, Schweinzer, J, Schworer, D, Scott, Sd, Sergienko, G, Sertoli, M, Shabbir, A, Sharapov, Se, Shaw, A, Sheikh, H, Shepherd, A, Shevelev, A, Shiraki, D, Shumack, A, Sias, G, Sibbald, M, Sieglin, B, Silburn, S, Silva, J, Silva, A, Silva, C, Silvagni, D, Simmons, P, Simpson, J, Sinha, A, Sipila, Sk, Sips, Acc, Siren, P, Sirinelli, A, Sjostrand, H, Skiba, M, Skilton, R, Skvara, V, Slade, B, Smith, R, Smith, P, Smith, Sf, Snoj, L, Soare, S, Solano, Er, Somers, A, Sommariva, C, Sonato, P, Sos, M, Sousa, J, Sozzi, C, Spagnolo, S, Sparapani, P, Spelzini, T, Spineanu, F, Sprada, D, Sridhar, S, Stables, G, Stallard, J, Stamatelatos, I, Stamp, Mf, Stan-Sion, C, Stancar, Z, Staniec, P, Stankunas, G, Stano, M, Stavrou, C, Stefanikova, E, Stepanov, I, Stephen, Av, Stephen, M, Stephens, J, Stevens, B, Stober, J, Stokes, C, Strachan, J, Strand, P, Strauss, Hr, Strom, P, Studholme, W, Subba, F, Suchkov, E, Summers, Hp, Sun, H, Sutton, N, Svensson, J, Sytnykov, D, Szabolics, T, Szepesi, G, Suzuki, Tt, Tabares, F, Tadic, T, Tal, B, Tala, T, Taliercio, C, Tallargio, A, Tanaka, K, Tang, W, Tardocchi, M, Tatali, R, Taylor, D, Tegnered, D, Telesca, G, Teplova, N, Teplukhina, A, Terranova, D, Terry, C, Testa, D, Tholerus, E, Thomas, J, Thompson, Vk, Thornton, A, Tierens, W, Tiseanu, I, Tojo, H, Tokitani, M, Tolias, P, Tomes, M, Trimble, P, Tripsky, M, Tsalas, M, Tsavalas, P, Tskhakaya, D, Jun, Dt, Turner, I, Turner, Mm, Turnyanskiy, M, Tvalashvili, G, Tyshchenko, M, Uccello, A, Uljanovs, J, Urano, H, Urban, A, Urbanczyk, G, Uytdenhouwen, I, Vadgama, A, Valcarcel, D, Vale, R, Valentinuzzi, M, Valerii, K, Valisa, M, Olivares, Pv, Valovic, M, Van Eester, D, Van Renterghem, W, van Rooij, Gj, Varje, J, Vartanian, S, Vasava, K, Vasilopoulou, T, Vecsei, M, Vega, J, Ventre, S, Verdoolaege, G, Verona, C, Rinati, Gv, Veshchev, E, Vianello, N, Vicente, J, Viezzer, E, Villari, S, Villone, F, Vincent, M, Vincenzi, P, Vinyar, I, Viola, B, Vitins, A, Vizvary, Z, Vlad, M, Voitsekhovitch, I, Voltolina, D, von Toussaint, U, Vondracek, P, Vuksic, M, Wakeling, B, Waldon, C, Walkden, N, Walker, R, Walker, M, Walsh, M, Wang, N, Wang, E, Warder, S, Warren, R, Waterhouse, J, Watts, C, Wauters, T, Webb, M, Weckmann, A, Weiland, J, Weiland, M, Weisen, H, Weiszflog, M, Welch, P, West, A, Wheatley, M, Wheeler, S, Whitehead, Am, Whittaker, D, Widdowson, Am, Wiesen, S, Wilkie, G, Williams, J, Willoughby, D, Wilson, J, Wilson, I, Wilson, Hr, Wischmeier, M, Withycombe, A, Witts, D, Wolfrum, E, Wood, R, Woodley, R, Woodley, C, Wray, S, Wright, Jc, Wright, P, Wukitch, S, Wynn, A, Xiang, L, Xu, T, Xue, Y, Yadikin, D, Yakovenko, Y, Yanling, W, Yavorskij, V, Young, I, Young, R, Young, D, Zacks, J, Zagorski, R, Zaitsev, F, Zakharov, L, Zanino, R, Zarins, A, Zarins, R, Fernandez, Dz, Zastrow, Kd, Zerbini, M, Zhang, W, Zhou, Y, Zilli, E, Zocco, A, Zoita, V, Zoletnik, S, Zwingmann, W, Zychor, I, and JET Contributors
Subjects: Physics, Nuclear and High Energy Physics, Fusion, Jet (fluid), Maximum power principle, Nuclear engineering, Context (language use), Plasma, Fusion power, Condensed Matter Physics, 01 natural sciences, 7. Clean energy, ICRH, Charged particle, 010305 fluids & plasmas, JET, transport, TRANSPORT, Physics::Plasma Physics, Beta (plasma physics), 0103 physical sciences, 010306 general physics
Abstract: Predictability of burning plasmas is a key issue for designing and building credible future fusion devices. In this context, an important effort of physics understanding and guidance is being carried out in parallel to the on-going JET experimental campaigns in H, D and T by performing analyses and modelling towards an improvement of the understanding of DT physics for the optimization of the JET-DT neutron yield and fusion born alpha particle physics. Extrapolations to JET-DT from recent experiments using the maximum power available have been performed including some of the most sophisticated codes and a broad selection of models. There is a general agreement that 11-15MW of fusion power can be expected in DT for the hybrid and baseline scenarios. On the other hand, in high beta, torque and fast ion fraction conditions, isotope effects could be favourable leading to higher fusion yield. It is shown that alpha particles related physics, such as TAE destabilization or fusion power electron heating, could be studied in ITER relevant JET-DT plasmas.
Published: 2019
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3. Adaptive learning for disruption prediction in non-stationary conditions

Author: Murari, A., Lungaroni, M., Gelfusa, M., Peluso, E., Vega, J., Abduallev, S., Abhangi, M., Abreu, P., Afanasev, V, Afzal, M., Aggarwal, K. M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Alarcon, T., Albanese, R., Alegre, D., Aleiferis, S., Alessi, E., Aleynikov, P., Alkseev, A., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V, Sunden, E. Andersson, Andrews, R., Angelone, M., Anghel, M., Angioni, C., Appel, L., Appelbee, C., Arena, P., Ariola, M., Arshad, S., Artaud, J., Arter, W., Ash, A., Ashikawa, N., Aslanyan, V, Asunta, O., Asztalos, O., Auriemma, F., Austin, Y., Avotina, L., Axton, M., Ayres, C., Baciero, A., Baiao, D., Balboa, I, Balden, M., Balshaw, N., Bandaru, V. K., Banks, J., Baranov, Y. F., Barcellona, C., Barnard, T., Barnes, M., Barnsley, R., Wiechec, A. Baron, Orte, L. Barrera, Baruzzo, M., Basiuk, V, Bassan, M., Bastow, R., Batista, A., Batistoni, P., Baumane, L., Bauvir, B., Baylor, L., Beaumont, P. S., Beckers, M., Beckett, B., Bekris, N., Beldishevski, M., Bell, K., Belli, F., Belonohy, E., Benayas, J., Bergsaker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Besiliu, C., Betar, H., Beurskens, M., Bielecki, J., Biewer, T., Bilato, R., Biletskyi, O., Bilkova, P., Binda, F., Birkenmeier, G., Bizarro, J. P. S., Bjorkas, C., Blackburn, J., Blackman, T. R., Blanchard, P., Blatchford, P., Bobkov, V, Boboc, A., Bogar, O., Bohm, P., Bohm, T., Bolshakova, I, Bolzonella, T., Bonanomi, N., Boncagni, L., Bonfiglio, D., Bonnin, X., Boom, J., Borba, D., Borodin, D., Borodkina, I, Boulbe, C., Bourdelle, C., Bowden, M., Bowman, C., Boyce, T., Boyer, H., Bradnam, S. C., Braic, V, Bravanec, R., Breizman, B., Brennan, D., Breton, S., Brett, A., Brezinsek, S., Bright, M., Brix, M., Broeckx, W., Brombin, M., Broslawski, A., Brown, B., Brunetti, D., Bruno, E., Buch, J., Buchanan, J., Buckingham, R., Buckley, M., Bucolo, M., Budny, R., Bufferand, H., Buller, S., Bunting, P., Buratti, P., Burckhart, A., Burroughes, G., Buscarino, A., Busse, A., Butcher, D., Butler, B., Bykov, I, Cahyna, P., Calabro, G., Calacci, L., Callaghan, D., Callaghan, J., Calvo, I, Camenen, Y., Camp, P., Campling, D. C., Cannas, B., Capat, A., Carcangiu, S., Card, P., Cardinali, A., Carman, P., Carnevale, D., Carr, M., Carralero, D., Carraro, L., Carvalho, B. B., Carvalho, I, Carvalho, P., Carvalho, D. D., Casson, F. J., Castaldo, C., Catarino, N., Causa, F., Cavazzana, R., Cave-Ayland, K., Cavedon, M., Cecconello, M., Ceccuzzi, S., Cecil, E., Challis, C. D., Chandra, D., Chang, C. S., Chankin, A., Chapman, I. T., Chapman, B., Chapman, S. C., Chernyshova, M., Chiariello, A., Chitarin, G., Chmielewski, P., Chone, L., Ciraolo, G., Ciric, D., Citrin, J., Clairet, F., Clark, M., Clark, E., Clarkson, R., Clay, R., Clements, C., Coad, J. P., Coates, P., Cobalt, A., Coccorese, V, Cocilovo, V, Coelho, R., Coenen, J. W., Coffey, I, Colas, L., Colling, B., Collins, S., Conka, D., Conroy, S., Conway, N., Coombs, D., Cooper, S. R., Corradino, C., Corre, Y., Corrigan, G., Coster, D., Craciunescu, T., Cramp, S., Crapper, C., Crisanti, F., Croci, G., Croft, D., Crombe, K., Cruz, N., Cseh, G., Cufar, A., Cullen, A., Curson, P., Curuia, M., Czarnecka, A., Czarski, T., Cziegler, I, Dabirikhah, H., Dal Molin, A., Dalgliesh, P., Dalley, S., Dankowski, J., Darrow, D., David, P., Davies, A., Davis, W., Dawson, K., Day, I, Day, C., De Bock, M., de Castro, A., De Dominici, G., de la Cal, E., de la Luna, E., De Masi, G., De Temmerman, G., De Tommasi, G., de Vries, P., Deane, J., Dejarnac, R., Del Sarto, D., Delabie, E., Demerdzhiev, V, Dempsey, A., den Harder, N., Dendy, R. O., Denis, J., Denner, P., Devaux, S., Devynck, P., Di Maio, F., Di Siena, A., Di Troia, C., Dickinson, D., Dinca, P., Dittmar, T., Dobrashian, J., Doerk, H., Doerner, R. P., Domptail, F., Donne, T., Dorling, S. E., Douai, D., Dowson, S., Drenik, A., Dreval, M., Drewelow, P., Drews, P., Duckworth, Ph, Dumont, R., Dumortier, P., Dunai, D., Dunne, M., Duran, I, Durodie, F., Dutta, P., Duval, B. P., Dux, R., Dylst, K., Edappala, P., V, Edwards, A. M., Edwards, J. S., Eich, Th, Eidietis, N., Eksaeva, A., Ellis, R., Ellwood, G., Elsmore, C., Emery, S., Enachescu, M., Ericsson, G., Eriksson, J., Eriksson, F., Eriksson, L. G., Ertmer, S., Esquembri, S., Esquisabel, A. L., Esser, H. G., Ewart, G., Fable, E., Fagan, D., Faitsch, M., Falie, D., Fanni, A., Farahani, A., Fasoli, A., Faugeras, B., Fazinic, S., Felici, F., Felton, R. C., Feng, S., Fernades, A., Fernandes, H., Ferreira, J., Ferreira, D. R., Ferro, G., Fessey, J. A., Ficker, O., Field, A., Fietz, S., Figini, L., Figueiredo, J., Figueiredo, A., Fil, N., Finburg, P., Fischer, U., Fittill, L., Fitzgerald, M., Flammini, D., Flanagan, J., Flinders, K., Foley, S., Fonnesu, N., Fontdecaba, J. M., Formisano, A., Forsythe, L., Fortuna, L., Fransson, E., Frasca, M., Frassinetti, L., Freisinger, M., Fresa, R., Fridstrom, R., Frigione, D., Fuchs, V, Fusco, V, Futatani, S., Gal, K., Galassi, D., Galazka, K., Galeani, S., Gallart, D., Galvao, R., Gao, Y., Garcia, J., Garcia-Carrasco, A., Garcia-Munoz, M., Gardener, M., Garzotti, L., Gaspar, J., Gaudio, P., Gear, D., Gebhart, T., Gee, S., Geiger, B., George, R., Gerasimov, S., Gervasini, G., Gethins, M., Ghani, Z., Ghate, M., Gherendi, M., Ghezzi, F., Giacalone, J. C., Giacomelli, L., Giacometti, G., Gibson, K., Giegerich, T., Gil, L., Gilbert, M. R., Gin, D., Giovannozzi, E., Giroud, C., Gloeggler, S., Goff, J., Gohil, P., Goloborod'Ko, V, Gomes, R., Goncalves, B., Goniche, M., Goodyear, A., Gorini, G., Goerler, T., Goulding, R., Goussarov, A., Graham, B., Graves, J. P., Greuner, H., Grierson, B., Griffiths, J., Griph, S., Grist, D., Groth, M., Grove, R., Gruca, M., Guard, D., Guerard, C., Guillemaut, C., Guirlet, R., Gulati, S., Gurl, C., Gutierrez-Milla, A., Utoh, H. H., Hackett, L., Hacquin, S., Hager, R., Hakola, A., Halitovs, M., Hall, S., Hallworth-Cook, S., Ham, C., Hamed, M., Hamilton, N., Hamlyn-Harris, C., Hammond, K., Hancu, G., Harrison, J., Harting, D., Hasenbeck, F., Hatano, Y., Hatch, D. R., Haupt, T., Hawes, J., Hawkes, N. C., Hawkins, J., Hawkins, P., Hazel, S., Heesterman, P., Heinola, K., Hellesen, C., Hellsten, T., Helou, W., Hemming, O., Hender, T. C., Henderson, S. S., Henderson, M., Henriques, R., Hepple, D., Herfindal, J., Hermon, G., Hidalgo, C., Higginson, W., Highcock, E. G., Hillesheim, J., Hillis, D., Hizanidis, K., Hjalmarsson, A., Ho, A., Hobirk, J., Hogben, C. H. A., Hogeweij, G. M. D., Hollingsworth, A., Hollis, S., Hoelzl, M., Honore, J-J, Hook, M., Hopley, D., Horacek, J., Hornung, G., Horton, A., Horton, L. D., Horvath, L., Hotchin, S. P., Howell, R., Hubbard, A., Huber, A., Huber, V, Huddleston, T. M., Hughes, M., Hughes, J., Huijsmans, G. T. A., Huynh, P., Hynes, A., Igaune, I., Iglesias, D., Imazawa, N., Imrisek, M., Incelli, M., Innocente, P., Ivanova-Stanik, I., Ivings, E., Jachmich, S., Jackson, A., Jackson, T., Jacquet, P., Jansons, J., Jaulmes, F., Jednorog, S., Jenkins, I, Jepu, I, Johnson, T., Johnson, R., Johnston, J., Joita, L., Joly, J., Jonasson, E., Jones, T., Jones, C., Jones, L., Jones, G., Jones, N., Juvonen, M., Hoshino, K. K., Kallenbach, A., Kalsey, M., Kaltiaisenaho, T., Kamiya, K., Kaniewski, J., Kantor, A., Kappatou, A., Karhunen, J., Karkinsky, D., Kaufman, M., Kaveney, G., Kazakov, Y., Kazantzidis, V, Keeling, D. L., Keenan, F. P., Kempenaars, M., Kent, O., Kent, J., Keogh, K., Khilkevich, E., Kim, H-T, Kim, H. T., King, R., King, D., Kinna, D. J., Kiptily, V, Kirk, A., Kirov, K., Kirschner, A., Kizane, G., Klas, M., Klepper, C., Klix, A., Knight, M., Knight, P., Knipe, S., Knott, S., Kobuchi, T., Kochl, F., Kocsis, G., Kodeli, I, Koechl, F., Kogut, D., Koivuranta, S., Kolesnichenko, Y., Kollo, Z., Kominis, Y., Koeppen, M., Korolczuk, S., Kos, B., Koslowski, H. R., Kotschenreuther, M., Koubiti, M., Kovaldins, R., Kovanda, O., Kowalska-Strzeciwilk, E., Krasilnikov, A., Krasilnikov, V, Krawczyk, N., Kresina, M., Krieger, K., Krivska, A., Kruezi, U., Ksiazek, I, Kukushkin, A., Kundu, A., Kurki-Suonio, T., Kwak, S., Kwon, O. J., Laguardia, L., Lahtinen, A., Laing, A., Lalousis, P., Lam, N., Lamb, C., Lambertz, H. T., Lang, P. T., Lanthaler, S., Neto, E. Lascas, Laszynska, E., Lawless, R., Lawson, K. D., Lazaros, A., Lazzaro, E., Leach, R., Learoyd, G., Leerink, S., Lefebvre, X., Leggate, H. J., Lehmann, J., Lehnen, M., Leichauer, P., Leichtle, D., Leipold, F., Lengar, I, Lennholm, M., Lepiavko, B., Leppanen, J., Lerche, E., Lescinskis, A., Lescinskis, B., Lesnoj, S., Leyland, M., Leysen, W., Li, Y., Li, L., Liang, Y., Likonen, J., Linke, J., Linsmeier, Ch, Lipschultz, B., Litaudon, X., Liu, G., Lloyd, B., Lo Schiavo, V. P., Loarer, T., Loarte, A., Lomanowski, B., Lomas, P. J., Lonnroth, J., Lopez, J. M., Lorenzini, R., Losada, U., Loughlin, M., Lowry, C., Luce, T., Lucock, R., Lukin, A., Luna, C., Lungu, C. P., Lungu, M., Lunniss, A., Lunt, T., Lupelli, I, Lutsenko, V, Lyssoivan, A., Macheta, P., Macusova, E., Magesh, B., Maggi, C., Maggiora, R., Mahesan, S., Maier, H., Mailloux, J., Maingi, R., Makwana, R., Malaquias, A., Malinowski, K., Malizia, A., Manas, P., Manduchi, G., Manso, M. E., Mantica, P., Mantsinen, M., Manzanares, A., Maquet, Ph, Marandet, Y., Marcenko, N., Marchetto, C., Marchuk, O., Marconato, N., Mariani, A., Marin, M., Marinelli, M., Marinucci, M., Markovic, T., Marocco, D., Marot, L., Marsh, J., Martin, A., Martin de Aguilera, A., Martin-Solis, J. R., Martone, R., Martynova, Y., Maruyama, S., Maslov, M., Matejcik, S., Mattei, M., Matthews, G. F., Matveev, D., Matveeva, E., Mauriya, A., Maviglia, F., May-Smith, T., Mayer, M., Mayoral, M. L., Mazon, D., Mazzotta, C., Mcadams, R., Mccarthy, P. J., Mcclements, K. G., Mccormack, O., Mccullen, P. A., Mcdonald, D., Mchardy, M., Mckean, R., Mckehon, J., Mcnamee, L., Meadowcroft, C., Meakins, A., Medley, S., Meigh, S., Meigs, A. 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Pires, Piron, L., Piron, C., Pironti, A., Pisano, F., Pitts, R., Plyusnin, V, Poli, F. M., Pomaro, N., Pompilian, O. G., Pool, P., Popovichev, S., Poradzinski, M., Porfiri, M. T., Porosnicu, C., Porton, M., Possnert, G., Potzel, S., Poulipoulis, G., Powell, T., Prajapati, V, Prakash, R., Predebon, I, Prestopino, G., Price, D., Price, M., Price, R., Primetzhofer, D., Prior, P., Pucella, G., Puglia, P., Puiatti, M. E., Purahoo, K., Pusztai, I, Puetterich, Th, Rachlew, E., Rack, M., Ragona, R., Rainford, M., Raj, P., Rakha, A., Ramogida, G., Ranjan, S., Rapson, C. J., Rasmussen, D., Rasmussen, J. J., Rathod, K., Ratta, G., Ratynskaia, S., Ravera, G., Rebai, M., Reed, A., Refy, D., Regana, J., Reich, M., Reid, N., Reimold, F., Reinhart, M., Reinke, M., Reiser, D., Rendell, D., Reux, C., Cortes, S. D. A. Reyes, Reynolds, S., Ricci, D., Richiusa, M., Rigamonti, D., Rimini, F. G., Risner, J., Riva, M., Rivero-Rodriguez, J., Roach, C., Robins, R., Robinson, S., Robson, D., Rodionov, R., Rodrigues, P., Rodriguez, J., Rohde, V, Romanelli, M., Romanelli, F., Romanelli, S., Romazanov, J., Rowe, S., Rubel, M., Rubinacci, G., Rubino, G., Ruchko, L., Ruset, C., Rzadkiewicz, J., Saarelma, S., Sabot, R., Saez, X., Safi, E., Sahlberg, A., Saibene, G., Saleem, M., Salewski, M., Salmi, A., Salmon, R., Salzedas, F., Samm, U., Sandiford, D., Santa, P., Santala, M. I. K., Santos, B., Santucci, A., Sartori, F., Sartori, R., Sauter, O., Scannell, R., Schluck, F., Schlummer, T., Schmid, K., Schmuck, S., Schoepf, K., Schweinzer, J., Schworer, D., Scott, S. D., Sergienko, G., Sertoli, M., Shabbir, A., Sharapov, S. E., Shaw, A., Sheikh, H., Shepherd, A., Shevelev, A., Shiraki, D., Shumack, A., Sias, G., Sibbald, M., Sieglin, B., Silburn, S., Silva, J., Silva, A., Silva, C., Silvagni, D., Simmons, P., Simpson, J., Sinha, A., Sipila, S. K., Sips, A. C. C., Siren, P., Sirinelli, A., Sjostrand, H., Skiba, M., Skilton, R., Skvara, V, Slade, B., Smith, R., Smith, P., Smith, S. F., Snoj, L., Soare, S., Solano, E. R., Somers, A., Sommariva, C., Sonato, P., Sos, M., Sousa, J., Sozzi, C., Spagnolo, S., Sparapani, P., Spelzini, T., Spineanu, F., Sprada, D., Sridhar, S., Stables, G., Stallard, J., Stamatelatos, I, Stamp, M. F., Stan-Sion, C., Stancar, Z., Staniec, P., Stankunas, G., Stano, M., Stavrou, C., Stefanikova, E., Stepanov, I, Stephen, A., Stephen, M., Stephens, J., Stevens, B., Stober, J., Stokes, C., Strachan, J., Strand, P., Strauss, H. R., Strom, P., Studholme, W., Subba, F., Suchkov, E., Summers, H. P., Sun, H., Sutton, N., Svensson, J., Sytnykov, D., Szabolics, T., Szepesi, G., Suzuki, T. T., Tabares, F., Tadic, T., Tal, B., Tala, T., Taliercio, C., Tallargio, A., Tanaka, K., Tang, W., Tardocchi, M., Tatali, R., Taylor, D., Tegnered, D., Telesca, G., Teplova, N., Teplukhina, A., Terranova, D., Terry, C., Testa, D., Tholerus, E., Thomas, J., Thompson, V. K., Thornton, A., Tierens, W., Tiseanu, I, Tojo, H., Tokitani, M., Tolias, P., Tomes, M., Trimble, P., Tripsky, M., Tsalas, M., Tsavalas, P., Tskhakaya, D., Jun, D. Tskhakaya, Turner, I, Turner, M. M., Turnyanskiy, M., Tvalashvili, G., Tyshchenko, M., Uccello, A., Uljanovs, J., Urano, H., Urban, A., Urbanczyk, G., Uytdenhouwen, I, Vadgama, A., Valcarcel, D., Vale, R., Valentinuzzi, M., Valerii, K., Valisa, M., Olivares, P. Vallejos, Valovic, M., Van Eester, D., Van Renterghem, W., van Rooij, G. J., Varje, J., Vartanian, S., Vasava, K., Vasilopoulou, T., Vecsei, M., Ventre, S., Verdoolaege, G., Verona, C., Rinati, G. 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Zilli, E, Zocco, A, Zoita, V, Zoletnik, S, Zwingmann, W, and Zychor, I
Subjects: Nuclear and High Energy Physics, Computer science, ensembles of classifiers, Machine learning, computer.software_genre, disruptions, 01 natural sciences, 010305 fluids & plasmas, obsolescence, Ensembles of classifiers, Stationary conditions, 0103 physical sciences, 010306 general physics, de-learning, Jet (fluid), business.industry, machine learning predictors, adaptive training, JET, Settore ING-IND/18 - Fisica dei Reattori Nucleari, machine learning predictor, Condensed Matter Physics, disruption, Obsolescence, Artificial intelligence, Adaptive learning, business, computer
Abstract: For many years, machine learning tools have proved to be very powerful disruption predictors in tokamaks. On the other hand, the vast majority of the techniques deployed assume that the input data is independent and is sampled from exactly the same probability distribution for the training set, the test set and the final real time deployment. This hypothesis is certainly not verified in practice, since the experimental programmes evolve quite rapidly, resulting typically in ageing of the predictors and consequent suboptimal performance. This paper describes various adaptive training strategies that have been tested to maintain the performance of disruption predictors in non- stationary conditions. The proposed approaches have been implemented using new ensembles of classifiers, explicitly developed for the present application. The improvements in performance are unquestionable and, given the difficulties encountered so far in translating predictors from one device to another, the proposed adaptive methods from scratch can therefore be considered a useful option in the arsenal of alternatives envisaged for the next generation of devices, particularly at the very beginning of their operation.
Published: 2019
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4. Role of fast ion pressure in the isotope effect in JET L-mode plasmas

Author: Bonanomi, N., Casiraghi, I, Mantica, P., Challis, C., Delabie, E., Fable, E., Gallart, D., Giroud, C., Lerche, E., Lomas, P., Menmuir, S., Staebler, G. M., Taylor, D., Van Eester, D., Abduallev, S., Abhangi, M., Abreu, P., Afanasev, V, Afzal, M., Aggarwal, K. M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Alarcon, T., Albanese, R., Alegre, D., Aleiferis, S., Alessi, E., Aleynikov, P., Alkseev, A., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V, Sunden, E. Andersson, Andrews, R., Angelone, M., Anghel, M., Angioni, C., Appel, L., Appelbee, C., Arena, P., Ariola, M., Arshad, S., Artaud, J., Arter, W., Ash, A., Ashikawa, N., Aslanyan, V, Asunta, O., Asztalos, O., Auriemma, F., Austin, Y., Avotina, L., Axton, M., Ayres, C., Baciero, A., Baiao, D., Balboa, I, Balden, M., Balshaw, N., Bandaru, V. K., Banks, J., Baranov, Y. F., Barcellona, C., Barnard, T., Barnes, M., Barnsley, R., Wiechec, A. Baron, Orte, L. Barrera, Baruzzo, M., Basiuk, V, Bassan, M., Bastow, R., Batista, A., Batistoni, P., Baumane, L., Bauvir, B., Baylor, L., Beaumont, P. S., Beckers, M., Beckett, B., Bekris, N., Beldishevski, M., Bell, K., Belli, F., Belonohy, E., Benayas, J., Bergsaker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Besiliu, C., Betar, H., Beurskens, M., Bielecki, J., Biewer, T., Bilato, R., Biletskyi, O., Bilkova, P., Binda, F., Birkenmeier, G., Bizarro, J. P. S., Bjorkas, C., Blackburn, J., Blackman, T. R., Blanchard, P., Blatchford, P., Bobkov, V, Boboc, A., Bogar, O., Bohm, P., Bohm, T., Bolshakova, I, Bolzonella, T., Boncagni, L., Bonfiglio, D., Bonnin, X., Boom, J., Borba, D., Borodin, D., Borodkina, I, Boulbe, C., Bourdelle, C., Bowden, M., Bowman, C., Boyce, T., Boyer, H., Bradnam, S. C., Braic, V, Bravanec, R., Breizman, B., Brennan, D., Breton, S., Brett, A., Brezinsek, S., Bright, M., Brix, M., Broeckx, W., Brombin, M., Broslawski, A., Brown, B., Brunetti, D., Bruno, E., Buch, J., Buchanan, J., Buckingham, R., Buckley, M., Bucolo, M., Budny, R., Bufferand, H., Buller, S., Bunting, P., Buratti, P., Burckhart, A., Burroughes, G., Buscarino, A., Busse, A., Butcher, D., Butler, B., Bykov, I, Cahyna, P., Calabro, G., Calacci, L., Callaghan, D., Callaghan, J., Calvo, I, Camenen, Y., Camp, P., Campling, D. C., Cannas, B., Capat, A., Carcangiu, S., Card, P., Cardinali, A., Carman, P., Carnevale, D., Carr, M., Carralero, D., Carraro, L., Carvalho, B. B., Carvalho, I, Carvalho, P., Carvalho, D. D., Casson, F. J., Castaldo, C., Catarino, N., Causa, F., Cavazzana, R., Cave-Ayland, K., Cavedon, M., Cecconello, M., Ceccuzzi, S., Cecil, E., Challis, C. D., Chandra, D., Chang, C. S., Chankin, A., Chapman, I. T., Chapman, B., Chapman, S. C., Chernyshova, M., Chiariello, A., Chitarin, G., Chmielewski, P., Chone, L., Ciraolo, G., Ciric, D., Citrin, J., Clairet, F., Clark, M., Clark, E., Clarkson, R., Clay, R., Clements, C., Coad, J. P., Coates, P., Cobalt, A., Coccorese, V, Cocilovo, V, Coelho, R., Coenen, J. W., Coffey, I, Colas, L., Colling, B., Collins, S., Conka, D., Conroy, S., Conway, N., Coombs, D., Cooper, S. R., Corradino, C., Corre, Y., Corrigan, G., Coster, D., Craciunescu, T., Cramp, S., Crapper, C., Crisanti, F., Croci, G., Croft, D., Crombe, K., Cruz, N., Cseh, G., Cufar, A., Cullen, A., Curson, P., Curuia, M., Czarnecka, A., Czarski, T., Cziegler, I, Dabirikhah, H., Dal Molin, A., Dalgliesh, P., Dalley, S., Dankowski, J., Darrow, D., David, P., Davies, A., Davis, W., Dawson, K., Day, I, Day, C., De Bock, M., de Castro, A., De Dominici, G., de la Cal, E., de la Luna, E., De Masi, G., De Temmerman, G., De Tommasi, G., de Vries, P., Deane, J., Dejarnac, R., Del Sarto, D., Demerdzhiev, V, Dempsey, A., den Harder, N., Dendy, R. O., Denis, J., Denner, P., Devaux, S., Devynck, P., Di Maio, F., Di Siena, A., Di Troia, C., Dickinson, D., Dinca, P., Dittmar, T., Dobrashian, J., Doerk, H., Doerner, R. P., Domptail, F., Donne, T., Dorling, S. E., Douai, D., Dowson, S., Drenik, A., Dreval, M., Drewelow, P., Drews, P., Duckworth, Ph, Dumont, R., Dumortier, P., Dunai, D., Dunne, M., Duran, I, Durodie, F., Dutta, P., Duval, B. P., Dux, R., Dylst, K., Edappala, P., V, Edwards, A. M., Edwards, J. S., Eich, Th, Eidietis, N., Eksaeva, A., Ellis, R., Ellwood, G., Elsmore, C., Emery, S., Enachescu, M., Ericsson, G., Eriksson, J., Eriksson, F., Eriksson, L. G., Ertmer, S., Esquembri, S., Esquisabel, A. L., Esser, H. G., Ewart, G., Fagan, D., Faitsch, M., Falie, D., Fanni, A., Farahani, A., Fasoli, A., Faugeras, B., Fazinic, S., Felici, F., Felton, R. C., Feng, S., Fernades, A., Fernandes, H., Ferreira, J., Ferreira, D. R., Ferro, G., Fessey, J. A., Ficker, O., Field, A., Fietz, S., Figini, L., Figueiredo, J., Figueiredo, A., Fil, N., Finburg, P., Fischer, U., Fittill, L., Fitzgerald, M., Flammini, D., Flanagan, J., Flinders, K., Foley, S., Fonnesu, N., Fontdecaba, J. M., Formisano, A., Forsythe, L., Fortuna, L., Fransson, E., Frasca, M., Frassinetti, L., Freisinger, M., Fresa, R., Fridstrom, R., Frigione, D., Fuchs, V, Fusco, V, Futatani, S., Gal, K., Galassi, D., Galazka, K., Galeani, S., Galvao, R., Gao, Y., Garcia, J., Garcia-Carrasco, A., Garcia-Munoz, M., Gardener, M., Garzotti, L., Gaspar, J., Gaudio, P., Gear, D., Gebhart, T., Gee, S., Geiger, B., Gelfusa, M., George, R., Gerasimov, S., Gervasini, G., Gethins, M., Ghani, Z., Ghate, M., Gherendi, M., Ghezzi, F., Giacalone, J. C., Giacomelli, L., Giacometti, G., Gibson, K., Giegerich, T., Gil, L., Gilbert, M. R., Gin, D., Giovannozzi, E., Gloeggler, S., Goff, J., Gohil, P., Goloborod'Ko, V, Gomes, R., Goncalves, B., Goniche, M., Goodyear, A., Gorini, G., Goerler, T., Goulding, R., Goussarov, A., Graham, B., Graves, J. P., Greuner, H., Grierson, B., Griffiths, J., Griph, S., Grist, D., Groth, M., Grove, R., Gruca, M., Guard, D., Guerard, C., Guillemaut, C., Guirlet, R., Gulati, S., Gurl, C., Gutierrez-Milla, A., Utoh, H. H., Hackett, L., Hacquin, S., Hager, R., Hakola, A., Halitovs, M., Hall, S., Hallworth-Cook, S., Ham, C., Hamed, M., Hamilton, N., Hamlyn-Harris, C., Hammond, K., Hancu, G., Harrison, J., Harting, D., Hasenbeck, F., Hatano, Y., Hatch, D. R., Haupt, T., Hawes, J., Hawkes, N. C., Hawkins, J., Hawkins, P., Hazel, S., Heesterman, P., Heinola, K., Hellesen, C., Hellsten, T., Helou, W., Hemming, O., Hender, T. C., Henderson, S. S., Henderson, M., Henriques, R., Hepple, D., Herfindal, J., Hermon, G., Hidalgo, C., Higginson, W., Highcock, E. G., Hillesheim, J., Hillis, D., Hizanidis, K., Hjalmarsson, A., Ho, A., Hobirk, J., Hogben, C. H. A., Hogeweij, G. M. D., Hollingsworth, A., Hollis, S., Hoelzl, M., Honore, J-J, Hook, M., Hopley, D., Horacek, J., Hornung, G., Horton, A., Horton, L. D., Horvath, L., Hotchin, S. P., Howell, R., Hubbard, A., Huber, A., Huber, V, Huddleston, T. M., Hughes, M., Hughes, J., Huijsmans, G. T. A., Huynh, P., Hynes, A., Igaune, I., Iglesias, D., Imazawa, N., Imrisek, M., Incelli, M., Innocente, P., Ivanova-Stanik, I., Ivings, E., Jachmich, S., Jackson, A., Jackson, T., Jacquet, P., Jansons, J., Jaulmes, F., Jednorog, S., Jenkins, I, Jepu, I, Johnson, T., Johnson, R., Johnston, J., Joita, L., Joly, J., Jonasson, E., Jones, T., Jones, C., Jones, L., Jones, G., Jones, N., Juvonen, M., Hoshino, K. K., Kallenbach, A., Kalsey, M., Kaltiaisenaho, T., Kamiya, K., Kaniewski, J., Kantor, A., Kappatou, A., Karhunen, J., Karkinsky, D., Kaufman, M., Kaveney, G., Kazakov, Y., Kazantzidis, V, Keeling, D. L., Keenan, F. P., Kempenaars, M., Kent, O., Kent, J., Keogh, K., Khilkevich, E., Kim, H-T, Kim, H. T., King, R., King, D., Kinna, D. J., Kiptily, V, Kirk, A., Kirov, K., Kirschner, A., Kizane, G., Klas, M., Klepper, C., Klix, A., Knight, M., Knight, P., Knipe, S., Knott, S., Kobuchi, T., Kochl, F., Kocsis, G., Kodeli, I, Koechl, F., Kogut, D., Koivuranta, S., Kolesnichenko, Y., Kollo, Z., Kominis, Y., Koeppen, M., Korolczuk, S., Kos, B., Koslowski, H. R., Kotschenreuther, M., Koubiti, M., Kovaldins, R., Kovanda, O., Kowalska-Strzeciwilk, E., Krasilnikov, A., Krasilnikov, V, Krawczyk, N., Kresina, M., Krieger, K., Krivska, A., Kruezi, U., Ksiazek, I, Kukushkin, A., Kundu, A., Kurki-Suonio, T., Kwak, S., Kwon, O. J., Laguardia, L., Lahtinen, A., Laing, A., Lalousis, P., Lam, N., Lamb, C., Lambertz, H. T., Lang, P. T., Lanthaler, S., Neto, E. Lascas, Laszynska, E., Lawless, R., Lawson, K. D., Lazaros, A., Lazzaro, E., Leach, R., Learoyd, G., Leerink, S., Lefebvre, X., Leggate, H. J., Lehmann, J., Lehnen, M., Leichauer, P., Leichtle, D., Leipold, F., Lengar, I, Lennholm, M., Lepiavko, B., Leppanen, J., Lescinskis, A., Lescinskis, B., Lesnoj, S., Leyland, M., Leysen, W., Li, Y., Li, L., Liang, Y., Likonen, J., Linke, J., Linsmeier, Ch, Lipschultz, B., Litaudon, X., Liu, G., Lloyd, B., Lo Schiavo, V. P., Loarer, T., Loarte, A., Lomanowski, B., Lomas, P. J., Lonnroth, J., Lopez, J. M., Lorenzini, R., Losada, U., Loughlin, M., Lowry, C., Luce, T., Lucock, R., Lukin, A., Luna, C., Lungaroni, M., Lungu, C. P., Lungu, M., Lunniss, A., Lunt, T., Lupelli, I, Lutsenko, V, Lyssoivan, A., Macheta, P., Macusova, E., Magesh, B., Maggi, C., Maggiora, R., Mahesan, S., Maier, H., Mailloux, J., Maingi, R., Makwana, R., Malaquias, A., Malinowski, K., Malizia, A., Manas, P., Manduchi, G., Manso, M. E., Mantsinen, M., Manzanares, A., Maquet, Ph, Marandet, Y., Marcenko, N., Marchetto, C., Marchuk, O., Marconato, N., Mariani, A., Marin, M., Marinelli, M., Marinucci, M., Markovic, T., Marocco, D., Marot, L., Marsh, J., Martin, A., Martin de Aguilera, A., Martin-Solis, J. R., Martone, R., Martynova, Y., Maruyama, S., Maslov, M., Matejcik, S., Mattei, M., Matthews, G. F., Matveev, D., Matveeva, E., Mauriya, A., Maviglia, F., May-Smith, T., Mayer, M., Mayoral, M. L., Mazon, D., Mazzotta, C., Mcadams, R., Mccarthy, P. J., Mcclements, K. G., Mccormack, O., Mccullen, P. A., Mcdonald, D., Mchardy, M., Mckean, R., Mckehon, J., Mcnamee, L., Meadowcroft, C., Meakins, A., Medley, S., Meigh, S., Meigs, A. 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Pires, Piron, L., Piron, C., Pironti, A., Pisano, F., Pitts, R., Plyusnin, V, Poli, F. M., Pomaro, N., Pompilian, O. G., Pool, P., Popovichev, S., Poradzinski, M., Porfiri, M. T., Porosnicu, C., Porton, M., Possnert, G., Potzel, S., Poulipoulis, G., Powell, T., Prajapati, V, Prakash, R., Predebon, I, Prestopino, G., Price, D., Price, M., Price, R., Primetzhofer, D., Prior, P., Pucella, G., Puglia, P., Puiatti, M. E., Purahoo, K., Pusztai, I, Puetterich, Th, Rachlew, E., Rack, M., Ragona, R., Rainford, M., Raj, P., Rakha, A., Ramogida, G., Ranjan, S., Rapson, C. J., Rasmussen, D., Rasmussen, J. J., Rathod, K., Ratta, G., Ratynskaia, S., Ravera, G., Rebai, M., Reed, A., Refy, D., Regana, J., Reich, M., Reid, N., Reimold, F., Reinhart, M., Reinke, M., Reiser, D., Rendell, D., Reux, C., Cortes, S. D. A. Reyes, Reynolds, S., Ricci, D., Richiusa, M., Rigamonti, D., Rimini, F. G., Risner, J., Riva, M., Rivero-Rodriguez, J., Roach, C., Robins, R., Robinson, S., Robson, D., Rodionov, R., Rodrigues, P., Rodriguez, J., Rohde, V, Romanelli, M., Romanelli, F., Romanelli, S., Romazanov, J., Rowe, S., Rubel, M., Rubinacci, G., Rubino, G., Ruchko, L., Ruset, C., Rzadkiewicz, J., Saarelma, S., Sabot, R., Saez, X., Safi, E., Sahlberg, A., Saibene, G., Saleem, M., Salewski, M., Salmi, A., Salmon, R., Salzedas, F., Samm, U., Sandiford, D., Santa, P., Santala, M. I. K., Santos, B., Santucci, A., Sartori, F., Sartori, R., Sauter, O., Scannell, R., Schluck, F., Schlummer, T., Schmid, K., Schmuck, S., Schoepf, K., Schweinzer, J., Schworer, D., Scott, S. D., Sergienko, G., Sertoli, M., Shabbir, A., Sharapov, S. E., Shaw, A., Sheikh, H., Shepherd, A., Shevelev, A., Shiraki, D., Shumack, A., Sias, G., Sibbald, M., Sieglin, B., Silburn, S., Silva, J., Silva, A., Silva, C., Silvagni, D., Simmons, P., Simpson, J., Sinha, A., Sipila, S. K., Sips, A. C. C., Siren, P., Sirinelli, A., Sjostrand, H., Skiba, M., Skilton, R., Skvara, V, Slade, B., Smith, R., Smith, P., Smith, S. F., Snoj, L., Soare, S., Solano, E. R., Somers, A., Sommariva, C., Sonato, P., Sos, M., Sousa, J., Sozzi, C., Spagnolo, S., Sparapani, P., Spelzini, T., Spineanu, F., Sprada, D., Sridhar, S., Stables, G., Stallard, J., Stamatelatos, I, Stamp, M. F., Stan-Sion, C., Stancar, Z., Staniec, P., Stankunas, G., Stano, M., Stavrou, C., Stefanikova, E., Stepanov, I, Stephen, A., Stephen, M., Stephens, J., Stevens, B., Stober, J., Stokes, C., Strachan, J., Strand, P., Strauss, H. R., Strom, P., Studholme, W., Subba, F., Suchkov, E., Summers, H. P., Sun, H., Sutton, N., Svensson, J., Sytnykov, D., Szabolics, T., Szepesi, G., Suzuki, T. T., Tabares, F., Tadic, T., Tal, B., Tala, T., Taliercio, C., Tallargio, A., Tanaka, K., Tang, W., Tardocchi, M., Tatali, R., Tegnered, D., Telesca, G., Teplova, N., Teplukhina, A., Terranova, D., Terry, C., Testa, D., Tholerus, E., Thomas, J., Thompson, V. K., Thornton, A., Tierens, W., Tiseanu, I, Tojo, H., Tokitani, M., Tolias, P., Tomes, M., Trimble, P., Tripsky, M., Tsalas, M., Tsavalas, P., Tskhakaya, D., Jun, D. Tskhakaya, Turner, I, Turner, M. M., Turnyanskiy, M., Tvalashvili, G., Tyshchenko, M., Uccello, A., Uljanovs, J., Urano, H., Urban, A., Urbanczyk, G., Uytdenhouwen, I, Vadgama, A., Valcarcel, D., Vale, R., Valentinuzzi, M., Valerii, K., Valisa, M., Olivares, P. Vallejos, Valovic, M., Van Renterghem, W., van Rooij, G. J., Varje, J., Vartanian, S., Vasava, K., Vasilopoulou, T., Vecsei, M., Vega, J., Ventre, S., Verdoolaege, G., Verona, C., Rinati, G. 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Zanino, R, Zarins, A, Zarins, R, Fernandez, Dz, Zastrow, Kd, Zerbini, M, Zhang, W, Zhou, Y, Zilli, E, Zocco, A, Zoita, V, Zoletnik, S, Zwingmann, W, Zychor, I, Department of Physics, and Materials Physics
Subjects: Nuclear and High Energy Physics, Materials science, Hydrogen, chemistry.chemical_element, 114 Physical sciences, 7. Clean energy, 01 natural sciences, 010305 fluids & plasmas, Ion, gyrokinetic, JET tokamak, Physics::Plasma Physics, equations, turbulent transport, fast ions, isotope effect, gyrokinetic simulations, 0103 physical sciences, Kinetic isotope effect, drift orbit width, fast ion, Physics::Atomic Physics, Nuclear Experiment, 010306 general physics, Jet (fluid), Stable isotope ratio, turbulence, Plasma, gyrokinetic simulation, Condensed Matter Physics, chemistry, Deuterium, confinement, transport, Physics::Space Physics, simulations, Atomic physics, DRIFT ORBIT WIDTH, CONFINEMENT, SIMULATIONS, TURBULENCE, TRANSPORT, EQUATIONS, Ion cyclotron resonance
Abstract: This paper presents results of JET ITER-like wall L-mode experiments in hydrogen and deuterium (D) plasmas, dedicated to the study of the isotope dependence of ion heat transport by determination of the ion critical gradient and stiffness by varying the ion cyclotron resonance heating power deposition. When no strong role of fast ions in the plasma core is expected, the main difference between the two isotope plasmas is determined by the plasma edge and the core behavior is consistent with a gyro-Bohm scaling. When the heating power (and the fast ion pressure) is increased, in addition to the difference in the edge region, also the plasma core shows substantial changes. The stabilization of ion heat transport by fast ions, clearly visible in D plasmas, appears to be weaker in H plasmas, resulting in a higher ion heat flux in H with apparent anti-gyro-Bohm mass scaling. The difference is found to be caused by the different fast ion pressure between H and D plasmas, related to the heating power settings and to the different fast ion slowing down time, and is completely accounted for in non-linear gyrokinetic simulations. The application of the TGLF quasi-linear model to this set of data is also discussed.
Published: 2019
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5. Ion cyclotron resonance heating scenarios for DEMO

Author: Van Eester, D., Lerche, E., Ragona, R., Messiaen, A., Wauters, T., Abduallev, S., Abhangi, M., Abreu, P., Afanasev, V, Afzal, M., Aggarwal, K. M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Alarcon, T., Albanese, R., Alegre, D., Aleiferis, S., Alessi, E., Aleynikov, P., Alkseev, A., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V, Sunden, E. Andersson, Andrews, R., Angelone, M., Anghel, M., Angioni, C., Appel, L., Appelbee, C., Arena, P., Ariola, M., Arshad, S., Artaud, J., Arter, W., Ash, A., Ashikawa, N., Aslanyan, V, Asunta, O., Asztalos, O., Auriemma, F., Austin, Y., Avotina, L., Axton, M., Ayres, C., Baciero, A., Baiao, D., Balboa, I, Balden, M., Balshaw, N., Bandaru, V. K., Banks, J., Baranov, Y. F., Barcellona, C., Barnard, T., Barnes, M., Barnsley, R., Wiechec, A. Baron, Orte, L. Barrera, Baruzzo, M., Basiuk, V, Bassan, M., Bastow, R., Batista, A., Batistoni, P., Baumane, L., Bauvir, B., Baylor, L., Beaumont, P. S., Beckers, M., Beckett, B., Bekris, N., Beldishevski, M., Bell, K., Belli, F., Belonohy, E., Benayas, J., Bergsaker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Besiliu, C., Betar, H., Beurskens, M., Bielecki, J., Biewer, T., Bilato, R., Biletskyi, O., Bilkova, P., Binda, F., Birkenmeier, G., Bizarro, J. P. S., Bjorkas, C., Blackburn, J., Blackman, T. R., Blanchard, P., Blatchford, P., Bobkov, V, Boboc, A., Bogar, O., Bohm, P., Bohm, T., Bolshakova, I, Bolzonella, T., Bonanomi, N., Boncagni, L., Bonfiglio, D., Bonnin, X., Boom, J., Borba, D., Borodin, D., Borodkina, I, Boulbe, C., Bourdelle, C., Bowden, M., Bowman, C., Boyce, T., Boyer, H., Bradnam, S. C., Braic, V, Bravanec, R., Breizman, B., Brennan, D., Breton, S., Brett, A., Brezinsek, S., Bright, M., Brix, M., Broeckx, W., Brombin, M., Broslawski, A., Brown, B., Brunetti, D., Bruno, E., Buch, J., Buchanan, J., Buckingham, R., Buckley, M., Bucolo, M., Budny, R., Bufferand, H., Buller, S., Bunting, P., Buratti, P., Burckhart, A., Burroughes, G., Buscarino, A., Busse, A., Butcher, D., Butler, B., Bykov, I, Cahyna, P., Calabro, G., Calacci, L., Callaghan, D., Callaghan, J., Calvo, I, Camenen, Y., Camp, P., Campling, D. C., Cannas, B., Capat, A., Carcangiu, S., Card, P., Cardinali, A., Carman, P., Carnevale, D., Carr, M., Carralero, D., Carraro, L., Carvalho, B. B., Carvalho, I, Carvalho, P., Carvalho, D. D., Casson, F. J., Castaldo, C., Catarino, N., Causa, F., Cavazzana, R., Cave-Ayland, K., Cavedon, M., Cecconello, M., Ceccuzzi, S., Cecil, E., Challis, C. D., Chandra, D., Chang, C. S., Chankin, A., Chapman, I. T., Chapman, B., Chapman, S. C., Chernyshova, M., Chiariello, A., Chitarin, G., Chmielewski, P., Chone, L., Ciraolo, G., Ciric, D., Citrin, J., Clairet, F., Clark, M., Clark, E., Clarkson, R., Clay, R., Clements, C., Coad, J. P., Coates, P., Cobalt, A., Coccorese, V, Cocilovo, V, Coelho, R., Coenen, J. W., Coffey, I, Colas, L., Colling, B., Collins, S., Conka, D., Conroy, S., Conway, N., Coombs, D., Cooper, S. R., Corradino, C., Corre, Y., Corrigan, G., Coster, D., Craciunescu, T., Cramp, S., Crapper, C., Crisanti, F., Croci, G., Croft, D., Crombe, K., Cruz, N., Cseh, G., Cufar, A., Cullen, A., Curson, P., Curuia, M., Czarnecka, A., Czarski, T., Cziegler, I, Dabirikhah, H., Dal Molin, A., Dalgliesh, P., Dalley, S., Dankowski, J., Darrow, D., David, P., Davies, A., Davis, W., Dawson, K., Day, I, Day, C., De Bock, M., de Castro, A., De Dominici, G., de la Cal, E., de la Luna, E., De Masi, G., De Temmerman, G., De Tommasi, G., de Vries, P., Deane, J., Dejarnac, R., Del Sarto, D., Delabie, E., Demerdzhiev, V, Dempsey, A., den Harder, N., Dendy, R. O., Denis, J., Denner, P., Devaux, S., Devynck, P., Di Maio, F., Di Siena, A., Di Troia, C., Dickinson, D., Dinca, P., Dittmar, T., Dobrashian, J., Doerk, H., Doerner, R. P., Domptail, F., Donne, T., Dorling, S. E., Douai, D., Dowson, S., Drenik, A., Dreval, M., Drewelow, P., Drews, P., Duckworth, Ph, Dumont, R., Dumortier, P., Dunai, D., Dunne, M., Duran, I, Durodie, F., Dutta, P., Duval, B. P., Dux, R., Dylst, K., Edappala, P. V., Edwards, A. M., Edwards, J. S., Eich, Th, Eidietis, N., Eksaeva, A., Ellis, R., Ellwood, G., Elsmore, C., Emery, S., Enachescu, M., Ericsson, G., Eriksson, J., Eriksson, F., Eriksson, L. G., Ertmer, S., Esquembri, S., Esquisabel, A. L., Esser, H. G., Ewart, G., Fable, E., Fagan, D., Faitsch, M., Falie, D., Fanni, A., Farahani, A., Fasoli, A., Faugeras, B., Fazinic, S., Felici, F., Felton, R. C., Feng, S., Fernades, A., Fernandes, H., Ferreira, J., Ferreira, D. R., Ferro, G., Fessey, J. A., Ficker, O., Field, A., Fietz, S., Figini, L., Figueiredo, J., Figueiredo, A., Fil, N., Finburg, P., Fischer, U., Fittill, L., Fitzgerald, M., Flammini, D., Flanagan, J., Flinders, K., Foley, S., Fonnesu, N., Fontdecaba, J. M., Formisano, A., Forsythe, L., Fortuna, L., Fransson, E., Frasca, M., Frassinetti, L., Freisinger, M., Fresa, R., Fridstrom, R., Frigione, D., Fuchs, V, Fusco, V, Futatani, S., Gal, K., Galassi, D., Galazka, K., Galeani, S., Gallart, D., Galvao, R., Gao, Y., Garcia, J., Garcia-Carrasco, A., Garcia-Munoz, M., Gardener, M., Garzotti, L., Gaspar, J., Gaudio, P., Gear, D., Gebhart, T., Gee, S., Geiger, B., Gelfusa, M., George, R., Gerasimov, S., Gervasini, G., Gethins, M., Ghani, Z., Ghate, M., Gherendi, M., Ghezzi, F., Giacalone, J. C., Giacomelli, L., Giacometti, G., Gibson, K., Giegerich, T., Gil, L., Gilbert, M. R., Gin, D., Giovannozzi, E., Giroud, C., Gloeggler, S., Goff, J., Gohil, P., Goloborod'ko, V, Gomes, R., Goncalves, B., Goniche, M., Goodyear, A., Gorini, G., Goerler, T., Goulding, R., Goussarov, A., Graham, B., Graves, J. P., Greuner, H., Grierson, B., Griffiths, J., Griph, S., Grist, D., Groth, M., Grove, R., Gruca, M., Guard, D., Guerard, C., Guillemaut, C., Guirlet, R., Gulati, S., Gurl, C., Gutierrez-Milla, A., Utoh, H. H., Hackett, L., Hacquin, S., Hager, R., Hakola, A., Halitovs, M., Hall, S., Hallworth-Cook, S., Ham, C., Hamed, M., Hamilton, N., Hamlyn-Harris, C., Hammond, K., Hancu, G., Harrison, J., Harting, D., Hasenbeck, F., Hatano, Y., Hatch, D. R., Haupt, T., Hawes, J., Hawkes, N. C., Hawkins, J., Hawkins, P., Hazel, S., Heesterman, P., Heinola, K., Hellesen, C., Hellsten, T., Helou, W., Hemming, O., Hender, T. C., Henderson, S. S., Henderson, M., Henriques, R., Hepple, D., Herfindal, J., Hermon, G., Hidalgo, C., Higginson, W., Highcock, E. G., Hillesheim, J., Hillis, D., Hizanidis, K., Hjalmarsson, A., Ho, A., Hobirk, J., Hogben, C. H. A., Hogeweij, G. M. D., Hollingsworth, A., Hollis, S., Hoelzl, M., Honore, J-J, Hook, M., Hopley, D., Horacek, J., Hornung, G., Horton, A., Horton, L. D., Horvath, L., Hotchin, S. P., Howell, R., Hubbard, A., Huber, A., Huber, V, Huddleston, T. M., Hughes, M., Hughes, J., Huijsmans, G. T. A., Huynh, P., Hynes, A., Igaune, I., Iglesias, D., Imazawa, N., Imrisek, M., Incelli, M., Innocente, P., Ivanova-Stanik, I., Ivings, E., Jachmich, S., Jackson, A., Jackson, T., Jacquet, P., Jansons, J., Jaulmes, F., Jednorog, S., Jenkins, I, Jepu, I, Johnson, T., Johnson, R., Johnston, J., Joita, L., Joly, J., Jonasson, E., Jones, T., Jones, C., Jones, L., Jones, G., Jones, N., Juvonen, M., Hoshino, K. K., Kallenbach, A., Kalsey, M., Kaltiaisenaho, T., Kamiya, K., Kaniewski, J., Kantor, A., Kappatou, A., Karhunen, J., Karkinsky, D., Kaufman, M., Kaveney, G., Kazakov, Y., Kazantzidis, V, Keeling, D. L., Keenan, F. P., Kempenaars, M., Kent, O., Kent, J., Keogh, K., Khilkevich, E., Kim, H-T, Kim, H. T., King, R., King, D., Kinna, D. J., Kiptily, V, Kirk, A., Kirov, K., Kirschner, A., Kizane, G., Klas, M., Klepper, C., Klix, A., Knight, M., Knight, P., Knipe, S., Knott, S., Kobuchi, T., Kochl, F., Kocsis, G., Kodeli, I, Koechl, F., Kogut, D., Koivuranta, S., Kolesnichenko, Y., Kollo, Z., Kominis, Y., Koeppen, M., Korolczuk, S., Kos, B., Koslowski, H. R., Kotschenreuther, M., Koubiti, M., Kovaldins, R., Kovanda, O., Kowalska-Strzeciwilk, E., Krasilnikov, A., Krasilnikov, V, Krawczyk, N., Kresina, M., Krieger, K., Krivska, A., Kruezi, U., Ksiazek, I, Kukushkin, A., Kundu, A., Kurki-Suonio, T., Kwak, S., Kwon, O. J., Laguardia, L., Lahtinen, A., Laing, A., Lalousis, P., Lam, N., Lamb, C., Lambertz, H. T., Lang, P. T., Lanthaler, S., Neto, E. Lascas, Laszynska, E., Lawless, R., Lawson, K. D., Lazaros, A., Lazzaro, E., Leach, R., Learoyd, G., Leerink, S., Lefebvre, X., Leggate, H. J., Lehmann, J., Lehnen, M., Leichauer, P., Leichtle, D., Leipold, F., Lengar, I, Lennholm, M., Lepiavko, B., Leppanen, J., Lescinskis, A., Lescinskis, B., Lesnoj, S., Leyland, M., Leysen, W., Li, Y., Li, L., Liang, Y., Likonen, J., Linke, J., Linsmeier, Ch, Lipschultz, B., Litaudon, X., Liu, G., Lloyd, B., Lo Schiavo, V. P., Loarer, T., Loarte, A., Lomanowski, B., Lomas, P. J., Lonnroth, J., Lopez, J. M., Lorenzini, R., Losada, U., Loughlin, M., Lowry, C., Luce, T., Lucock, R., Lukin, A., Luna, C., Lungaroni, M., Lungu, C. P., Lungu, M., Lunniss, A., Lunt, T., Lupelli, I, Lutsenko, V, Lyssoivan, A., Macheta, P., Macusova, E., Magesh, B., Maggi, C., Maggiora, R., Mahesan, S., Maier, H., Mailloux, J., Maingi, R., Makwana, R., Malaquias, A., Malinowski, K., Malizia, A., Manas, P., Manduchi, G., Manso, M. E., Mantica, P., Mantsinen, M., Manzanares, A., Maquet, Ph, Marandet, Y., Marcenko, N., Marchetto, C., Marchuk, O., Marconato, N., Mariani, A., Marin, M., Marinelli, M., Marinucci, M., Markovic, T., Marocco, D., Marot, L., Marsh, J., Martin, A., Martin de Aguilera, A., Martin-Solis, J. R., Martone, R., Martynova, Y., Maruyama, S., Maslov, M., Matejcik, S., Mattei, M., Matthews, G. F., Matveev, D., Matveeva, E., Mauriya, A., Maviglia, F., May-Smith, T., Mayer, M., Mayoral, M. L., Mazon, D., Mazzotta, C., McAdams, R., McCarthy, P. J., McClements, K. G., McCormack, O., McCullen, P. A., McDonald, D., McHardy, M., McKean, R., McKehon, J., McNamee, L., Meadowcroft, C., Meakins, A., Medley, S., Meigh, S., Meigs, A. G., Meisl, G., Meiter, S., Meitner, S., Meneses, L., Menmuir, S., Mergia, K., Merle, A., Merriman, P., Mertens, Ph, Meshchaninov, S., Meyer, H., Michling, R., Milanesio, D., Militello, F., Militello-Asp, E., Milocco, A., Miloshevsky, G., Mink, F., Minucci, S., Miron, I, Mistry, S., Miyoshi, Y., Mlynar, J., Moiseenko, V, Monaghan, P., Monakhov, I, Moon, S., Mooney, R., Moradi, S., Morales, J., Moran, J., Mordijck, S., Moreira, L., Moro, F., Morris, J., Moser, L., Mosher, S., Moulton, D., Mrowetz, T., Muir, A., Muraglia, M., Murari, A., Muraro, A., Murphy, S., Muscat, P., Muthusonai, N., Myers, C., Asakura, N. N., N'Konga, B., Nabais, F., Naish, R., Naish, J., Nakano, T., Napoli, F., Nardon, E., Naulin, V, Nave, M. F. F., Nedzelskiy, I, Nemtsev, G., Nesenevich, V, Nespoli, F., Neto, A., Neu, R., Neverov, V. S., Newman, M., Ng, S., Nicassio, M., Nielsen, A. H., Nina, D., Nishijima, D., Noble, C., Nobs, C. R., Nocente, M., Nodwell, D., Nordlund, K., Nordman, H., Normanton, R., Noterdaeme, J. M., Nowak, S., Nunes, I, O'Gorman, T., O'Mullane, M., Oberkofler, M., Oberparleiter, M., Odupitan, T., Ogawa, M. T., Okabayashi, M., Oliver, H., Olney, R., Omoregie, L., Ongena, J., Orsitto, F., Orszagh, J., Osborne, T., Otin, R., Owen, A., Owen, T., Paccagnella, R., Packer, L. W., Pajuste, E., Pamela, S., Panja, S., Papp, P., Papp, G., Parail, V, Pardanaud, C., Diaz, F. Parra, Parsloe, A., Parsons, N., Parsons, M., Pasqualotto, R., Passeri, M., Patel, A., Pathak, S., Patten, H., Pau, A., Pautasso, G., Pavlichenko, R., Pavone, A., Pawelec, E., Soldan, C. Paz, Peackoc, A., Pehkonen, S-P, Peluso, E., Penot, C., Penzo, J., Pepperell, K., Pereira, R., Cippo, E. Perelli, von Thun, C. Perez, Pericoli, V, Peruzzo, S., Peterka, M., Petersson, P., Petravich, G., Petre, A., Petrzilka, V, Philipps, V, Pigatto, L., Pillon, M., Pinches, S., Pintsuk, G., Piovesan, P., de Sa, W. Pires, dos Reis, A. Pires, Piron, L., Piron, C., Pironti, A., Pisano, F., Pitts, R., Plyusnin, V, Poli, F. M., Pomaro, N., Pompilian, O. G., Pool, P., Popovichev, S., Poradzinski, M., Porfiri, M. T., Porosnicu, C., Porton, M., Possnert, G., Potzel, S., Poulipoulis, G., Powell, T., Prajapati, V, Prakash, R., Predebon, I, Prestopino, G., Price, D., Price, M., Price, R., Primetzhofer, D., Prior, P., Pucella, G., Puglia, P., Puiatti, M. E., Purahoo, K., Pusztai, I, Puetterich, Th, Rachlew, E., Rack, M., Rainford, M., Raj, P., Rakha, A., Ramogida, G., Ranjan, S., Rapson, C. J., Rasmussen, D., Rasmussen, J. J., Rathod, K., Ratta, G., Ratynskaia, S., Ravera, G., Rebai, M., Reed, A., Refy, D., Regana, J., Reich, M., Reid, N., Reimold, F., Reinhart, M., Reinke, M., Reiser, D., Rendell, D., Reux, C., Cortes, S. D. A. Reyes, Reynolds, S., Ricci, D., Richiusa, M., Rigamonti, D., Rimini, F. G., Risner, J., Riva, M., Rivero-Rodriguez, J., Roach, C., Robins, R., Robinson, S., Robson, D., Rodionov, R., Rodrigues, P., Rodriguez, J., Rohde, V, Romanelli, M., Romanelli, F., Romanelli, S., Romazanov, J., Rowe, S., Rubel, M., Rubinacci, G., Rubino, G., Ruchko, L., Ruset, C., Rzadkiewicz, J., Saarelma, S., Sabot, R., Saez, X., Safi, E., Sahlberg, A., Saibene, G., Saleem, M., Salewski, M., Salmi, A., Salmon, R., Salzedas, F., Samm, U., Sandiford, D., Santa, P., Santala, M. I. K., Santos, B., Santucci, A., Sartori, F., Sartori, R., Sauter, O., Scannell, R., Schluck, F., Schlummer, T., Schmid, K., Schmuck, S., Schoepf, K., Schweinzer, J., Schworer, D., Scott, S. D., Sergienko, G., Sertoli, M., Shabbir, A., Sharapov, S. E., Shaw, A., Sheikh, H., Shepherd, A., Shevelev, A., Shiraki, D., Shumack, A., Sias, G., Sibbald, M., Sieglin, B., Silburn, S., Silva, J., Silva, A., Silva, C., Silvagni, D., Simmons, P., Simpson, J., Sinha, A., Sipila, S. K., Sips, A. C. C., Siren, P., Sirinelli, A., Sjostrand, H., Skiba, M., Skilton, R., Skvara, V, Slade, B., Smith, R., Smith, P., Smith, S. F., Snoj, L., Soare, S., Solano, E. R., Somers, A., Sommariva, C., Sonato, P., Sos, M., Sousa, J., Sozzi, C., Spagnolo, S., Sparapani, P., Spelzini, T., Spineanu, F., Sprada, D., Sridhar, S., Stables, G., Stallard, J., Stamatelatos, I, Stamp, M. F., Stan-Sion, C., Stancar, Z., Staniec, P., Stankunas, G., Stano, M., Stavrou, C., Stefanikova, E., Stepanov, I, Stephen, A. V., Stephen, M., Stephens, J., Stevens, B., Stober, J., Stokes, C., Strachan, J., Strand, P., Strauss, H. R., Strom, P., Studholme, W., Subba, F., Suchkov, E., Summers, H. P., Sun, H., Sutton, N., Svensson, J., Sytnykov, D., Szabolics, T., Szepesi, G., Suzuki, T. T., Tabares, F., Tadic, T., Tal, B., Tala, T., Taliercio, C., Tallargio, A., Tanaka, K., Tang, W., Tardocchi, M., Tatali, R., Taylor, D., Tegnered, D., Telesca, G., Teplova, N., Teplukhina, A., Terranova, D., Terry, C., Testa, D., Tholerus, E., Thomas, J., Thompson, V. K., Thornton, A., Tierens, W., Tiseanu, I, Tojo, H., Tokitani, M., Tolias, P., Tomes, M., Trimble, P., Tripsky, M., Tsalas, M., Tsavalas, P., Tskhakaya, D., Jun, D. Tskhakaya, Turner, I, Turner, M. M., Turnyanskiy, M., Tvalashvili, G., Tyshchenko, M., Uccello, A., Uljanovs, J., Urano, H., Urban, A., Urbanczyk, G., Uytdenhouwen, I, Vadgama, A., Valcarcel, D., Vale, R., Valentinuzzi, M., Valerii, K., Valisa, M., Olivares, P. Vallejos, Valovic, M., Van Renterghem, W., van Rooij, G. J., Varje, J., Vartanian, S., Vasava, K., Vasilopoulou, T., Vecsei, M., Vega, J., Ventre, S., Verdoolaege, G., Verona, C., Rinati, G. Verona, Veshchev, E., Vianello, N., Vicente, J., Viezzer, E., Villari, S., Villone, F., Vincent, M., Vincenzi, P., Vinyar, I, Viola, B., Vitins, A., Vizvary, Z., Vlad, M., Voitsekhovitch, I, Voltolina, D., von Toussaint, U., Vondracek, P., Vuksic, M., Wakeling, B., Waldon, C., Walkden, N., Walker, R., Walker, M., Walsh, M., Wang, N., Wang, E., Warder, S., Warren, R., Waterhouse, J., Watts, C., Webb, M., Weckmann, A., Weiland, J., Weiland, M., Weisen, H., Weiszflog, M., Welch, P., West, A., Wheatley, M., Wheeler, S., Whitehead, A. M., Whittaker, D., Widdowson, A. M., Wiesen, S., Wilkie, G., Williams, J., Willoughby, D., Wilson, J., Wilson, I, Wilson, H. R., Wischmeier, M., Withycombe, A., Witts, D., Wolfrum, E., Wood, R., Woodley, R., Woodley, C., Wray, S., Wright, J. C., Wright, P., Wukitch, S., Wynn, A., Xiang, L., Xu, T., Xue, Y., Yadikin, D., Yakovenko, Y., Yanling, W., Yavorskij, V, Young, I, Young, R., Young, D., Zacks, J., Zagorski, R., Zaitsev, F. S., Zakharov, L., Zanino, R., Zarins, A., Zarins, R., Fernandez, D. Zarzoso, Zastrow, K. D., Zerbini, M., Zhang, W., Zhou, Y., Zilli, E., Zocco, A., Zoita, V, Zoletnik, S., Zwingmann, W., Zychor, I, Department of Physics, Materials Physics, Van Eester, D, Lerche, E, Ragona, R, Messiaen, A, Wauters, T, Abduallev, S, Abhangi, M, Abreu, P, Afanasev, V, Afzal, M, Aggarwal, Km, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Alarcon, T, Albanese, R, Alegre, D, Aleiferis, S, Alessi, E, Aleynikov, P, Alkseev, A, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amosov, V, Sunden, Ea, Andrews, R, Angelone, M, Anghel, M, Angioni, C, Appel, L, Appelbee, C, Arena, P, Ariola, M, Arshad, S, Artaud, J, Arter, W, Ash, A, Ashikawa, N, Aslanyan, V, Asunta, O, Asztalos, O, Auriemma, F, Austin, Y, Avotina, L, Axton, M, Ayres, C, Baciero, A, Baiao, D, Balboa, I, Balden, M, Balshaw, N, Bandaru, Vk, Banks, J, Baranov, Yf, Barcellona, C, Barnard, T, Barnes, M, Barnsley, R, Wiechec, Ab, Orte, Lb, Baruzzo, M, Basiuk, V, Bassan, M, Bastow, R, Batista, A, Batistoni, P, Baumane, L, Bauvir, 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Zastrow, Kd, Zerbini, M, Zhang, W, Zhou, Y, Zilli, E, Zocco, A, Zoita, V, Zoletnik, S, Zwingmann, W, and Zychor, I
Subjects: Nuclear and High Energy Physics, Tokamak, Materials science, heating, Sawtooth wave, wave, discharges, 114 Physical sciences, 7. Clean energy, 01 natural sciences, 010305 fluids & plasmas, law.invention, law, Physics::Plasma Physics, 0103 physical sciences, Dielectric heating, icrh, 010306 general physics, tokamak, mode conversion, iter, minority, Plasma, Condensed Matter Physics, plasmas, Computational physics, ICRH, ITER, current drive, Ion cyclotron resonance heating, sawtooth, oscillations, systems code
Abstract: The present paper offers an overview of the potential of ion cyclotron resonance heating (ICRH) or radio frequency heating for the DEMO machine. It is found that various suitable heating schemes are available. Similar to ITER and in view of the limited bandwidth of about 10 MHz that can be achieved to ensure optimal functioning of the launcher, it is proposed to make core second harmonic tritium heating the key ion heating scheme, assisted by fundamental cyclotron heating He-3 in the early phase of the discharge; for the present design of DEMO-with a static magnetic field strength of B-o = 5.855 T-that places the T and 3He layers in the core for f = 60 MHz and suggests centering the bandwidth around that main operating frequency. In line with earlier studies for hot, dense plasmas in large-size magnetic confinement machines, it is shown that good single pass absorption is achieved but that the size as well as the operating density and temperature of the machine cause the electrons to absorb a non-negligible fraction of the power away from the core when core ion heating is aimed at. Current drive and alternative heating options are briefly discussed and a dedicated computation is done for the traveling wave antenna, proposed for DEMO in view of its compatibility with substantial antenna-plasma distances. The various tasks that ICRH can fulfill are briefly listed. Finally, the impact of transport and the sensitivity of the obtained results to changes in the machine parameters is commented on.
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6. A new mechanism for increasing density peaking in tokamaks: improvement of the inward particle pinch with edge E x B shearing

Author: Garcia, J., Doerk, H., Goerler, T., Abduallev, S., Abhangi, M., Abreu, P., Afanasev, V, Afzal, M., Aggarwal, K. M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Alarcon, T., Albanese, R., Alegre, D., Aleiferis, S., Alessi, E., Aleynikov, P., Alkseev, A., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V, Sunden, E. Andersson, Andrews, R., Angelone, M., Anghel, M., Angioni, C., Appel, L., Appelbee, C., Arena, P., Ariola, M., Arshad, S., Artaud, J., Arter, W., Ash, A., Ashikawa, N., Aslanyan, V, Asunta, O., Asztalos, O., Auriemma, F., Austin, Y., Avotina, L., Axton, M., Ayres, C., Baciero, A., Baiao, D., Balboa, I, Balden, M., Balshaw, N., Bandaru, V. K., Banks, J., Baranov, Y. F., Barcellona, C., Barnard, T., Barnes, M., Barnsley, R., Wiechec, A. Baron, Orte, L. Barrera, Baruzzo, M., Basiuk, V, Bassan, M., Bastow, R., Batista, A., Batistoni, P., Baumane, L., Bauvir, B., Baylor, L., Beaumont, P. S., Beckers, M., Beckett, B., Bekris, N., Beldishevski, M., Bell, K., Belli, F., Belonohy, E., Benayas, J., Bergsaker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Besiliu, C., Betar, H., Beurskens, M., Bielecki, J., Biewer, T., Bilato, R., Biletskyi, O., Bilkova, P., Binda, F., Birkenmeier, G., Bizarro, J. P. S., Bjorkas, C., Blackburn, J., Blackman, T. R., Blanchard, P., Blatchford, P., Bobkov, V, Boboc, A., Bogar, O., Bohm, P., Bohm, T., Bolshakova, I, Bolzonella, T., Bonanomi, N., Boncagni, L., Bonfiglio, D., Bonnin, X., Boom, J., Borba, D., Borodin, D., Borodkina, I, Boulbe, C., Bourdelle, C., Bowden, M., Bowman, C., Boyce, T., Boyer, H., Bradnam, S. C., Braic, V, Bravanec, R., Breizman, B., Brennan, D., Breton, S., Brett, A., Brezinsek, S., Bright, M., Brix, M., Broeckx, W., Brombin, M., Broslawski, A., Brown, B., Brunetti, D., Bruno, E., Buch, J., Buchanan, J., Buckingham, R., Buckley, M., Bucolo, M., Budny, R., Bufferand, H., Buller, S., Bunting, P., Buratti, P., Burckhart, A., Burroughes, G., Buscarino, A., Busse, A., Butcher, D., Butler, B., Bykov, I, Cahyna, P., Calabro, G., Calacci, L., Callaghan, D., Callaghan, J., Calvo, I, Camenen, Y., Camp, P., Campling, D. C., Cannas, B., Capat, A., Carcangiu, S., Card, P., Cardinali, A., Carman, P., Carnevale, D., Carr, M., Carralero, D., Carraro, L., Carvalho, B. B., Carvalho, I, Carvalho, P., Carvalho, D. D., Casson, F. J., Castaldo, C., Catarino, N., Causa, F., Cavazzana, R., Cave-Ayland, K., Cavedon, M., Cecconello, M., Ceccuzzi, S., Cecil, E., Challis, C. D., Chandra, D., Chang, C. S., Chankin, A., Chapman, I. T., Chapman, B., Chapman, S. C., Chernyshova, M., Chiariello, A., Chitarin, G., Chmielewski, P., Chone, L., Ciraolo, G., Ciric, D., Citrin, J., Clairet, F., Clark, M., Clark, E., Clarkson, R., Clay, R., Clements, C., Coad, J. P., Coates, P., Cobalt, A., Coccorese, V, Cocilovo, V, Coelho, R., Coenen, J. W., Coffey, I, Colas, L., Colling, B., Collins, S., Conka, D., Conroy, S., Conway, N., Coombs, D., Cooper, S. R., Corradino, C., Corre, Y., Corrigan, G., Coster, D., Craciunescu, T., Cramp, S., Crapper, C., Crisanti, F., Croci, G., Croft, D., Crombe, K., Cruz, N., Cseh, G., Cufar, A., Cullen, A., Curson, P., Curuia, M., Czarnecka, A., Czarski, T., Cziegler, I, Dabirikhah, H., Dal Molin, A., Dalgliesh, P., Dalley, S., Dankowski, J., Darrow, D., David, P., Davies, A., Davis, W., Dawson, K., Day, I, Day, C., De Bock, M., de Castro, A., De Dominici, G., de la Cal, E., de la Luna, E., De Masi, G., De Temmerman, G., De Tommasi, G., de Vries, P., Deane, J., Dejarnac, R., Del Sarto, D., Delabie, E., Demerdzhiev, V, Dempsey, A., den Harder, N., Dendy, R. O., Denis, J., Denner, P., Devaux, S., Devynck, P., Di Maio, F., Di Siena, A., Di Troia, C., Dickinson, D., Dinca, P., Dittmar, T., Dobrashian, J., Doerner, R. P., Domptail, F., Donne, T., Dorling, S. E., Douai, D., Dowson, S., Drenik, A., Dreval, M., Drewelow, P., Drews, P., Duckworth, Ph, Dumont, R., Dumortier, P., Dunai, D., Dunne, M., Duran, I, Durodie, F., Dutta, P., Duval, B. P., Dux, R., Dylst, K., Edappala, P., V, Edwards, A. M., Edwards, J. S., Eich, Th, Eidietis, N., Eksaeva, A., Ellis, R., Ellwood, G., Elsmore, C., Emery, S., Enachescu, M., Ericsson, G., Eriksson, J., Eriksson, F., Eriksson, L. G., Ertmer, S., Esquembri, S., Esquisabel, A. L., Esser, H. G., Ewart, G., Fable, E., Fagan, D., Faitsch, M., Falie, D., Fanni, A., Farahani, A., Fasoli, A., Faugeras, B., Fazinic, S., Felici, F., Felton, R. C., Feng, S., Fernades, A., Fernandes, H., Ferreira, J., Ferreira, D. R., Ferro, G., Fessey, J. A., Ficker, O., Field, A., Fietz, S., Figini, L., Figueiredo, J., Figueiredo, A., Fil, N., Finburg, P., Fischer, U., Fittill, L., Fitzgerald, M., Flammini, D., Flanagan, J., Flinders, K., Foley, S., Fonnesu, N., Fontdecaba, J. M., Formisano, A., Forsythe, L., Fortuna, L., Fransson, E., Frasca, M., Frassinetti, L., Freisinger, M., Fresa, R., Fridstrom, R., Frigione, D., Fuchs, V, Fusco, V, Futatani, S., Gal, K., Galassi, D., Galazka, K., Galeani, S., Gallart, D., Galvao, R., Gao, Y., Garcia-Carrasco, A., Garcia-Munoz, M., Gardener, M., Garzotti, L., Gaspar, J., Gaudio, P., Gear, D., Gebhart, T., Gee, S., Geiger, B., Gelfusa, M., George, R., Gerasimov, S., Gervasini, G., Gethins, M., Ghani, Z., Ghate, M., Gherendi, M., Ghezzi, F., Giacalone, J. C., Giacomelli, L., Giacometti, G., Gibson, K., Giegerich, T., Gil, L., Gilbert, M. R., Gin, D., Giovannozzi, E., Giroud, C., Gloeggler, S., Goff, J., Gohil, P., Goloborod'Ko, V, Gomes, R., Goncalves, B., Goniche, M., Goodyear, A., Gorini, G., Goulding, R., Goussarov, A., Graham, B., Graves, J. P., Greuner, H., Grierson, B., Griffiths, J., Griph, S., Grist, D., Groth, M., Grove, R., Gruca, M., Guard, D., Guerard, C., Guillemaut, C., Guirlet, R., Gulati, S., Gurl, C., Gutierrez-Milla, A., Utoh, H. H., Hackett, L., Hacquin, S., Hager, R., Hakola, A., Halitovs, M., Hall, S., Hallworth-Cook, S., Ham, C., Hamed, M., Hamilton, N., Hamlyn-Harris, C., Hammond, K., Hancu, G., Harrison, J., Harting, D., Hasenbeck, F., Hatano, Y., Hatch, D. R., Haupt, T., Hawes, J., Hawkes, N. C., Hawkins, J., Hawkins, P., Hazel, S., Heesterman, P., Heinola, K., Hellesen, C., Hellsten, T., Helou, W., Hemming, O., Hender, T. C., Henderson, S. S., Henderson, M., Henriques, R., Hepple, D., Herfindal, J., Hermon, G., Hidalgo, C., Higginson, W., Highcock, E. G., Hillesheim, J., Hillis, D., Hizanidis, K., Hjalmarsson, A., Ho, A., Hobirk, J., Hogben, C. H. A., Hogeweij, G. M. D., Hollingsworth, A., Hollis, S., Hoelzl, M., Honore, J-J, Hook, M., Hopley, D., Horacek, J., Hornung, G., Horton, A., Horton, L. D., Horvath, L., Hotchin, S. P., Howell, R., Hubbard, A., Huber, A., Huber, V, Huddleston, T. M., Hughes, M., Hughes, J., Huijsmans, G. T. A., Huynh, P., Hynes, A., Igaune, I., Iglesias, D., Imazawa, N., Imrisek, M., Incelli, M., Innocente, P., Ivanova-Stanik, I., Ivings, E., Jachmich, S., Jackson, A., Jackson, T., Jacquet, P., Jansons, J., Jaulmes, F., Jednorog, S., Jenkins, I, Jepu, I, Johnson, T., Johnson, R., Johnston, J., Joita, L., Joly, J., Jonasson, E., Jones, T., Jones, C., Jones, L., Jones, G., Jones, N., Juvonen, M., Hoshino, K. K., Kallenbach, A., Kalsey, M., Kaltiaisenaho, T., Kamiya, K., Kaniewski, J., Kantor, A., Kappatou, A., Karhunen, J., Karkinsky, D., Kaufman, M., Kaveney, G., Kazakov, Y., Kazantzidis, V, Keeling, D. L., Keenan, F. P., Kempenaars, M., Kent, O., Kent, J., Keogh, K., Khilkevich, E., Kim, H-T, Kim, H. T., King, R., King, D., Kinna, D. J., Kiptily, V, Kirk, A., Kirov, K., Kirschner, A., Kizane, G., Klas, M., Klepper, C., Klix, A., Knight, M., Knight, P., Knipe, S., Knott, S., Kobuchi, T., Kochl, F., Kocsis, G., Kodeli, I, Koechl, F., Kogut, D., Koivuranta, S., Kolesnichenko, Y., Kollo, Z., Kominis, Y., Koeppen, M., Korolczuk, S., Kos, B., Koslowski, H. R., Kotschenreuther, M., Koubiti, M., Kovaldins, R., Kovanda, O., Kowalska-Strzeciwilk, E., Krasilnikov, A., Krasilnikov, V, Krawczyk, N., Kresina, M., Krieger, K., Krivska, A., Kruezi, U., Ksiazek, I, Kukushkin, A., Kundu, A., Kurki-Suonio, T., Kwak, S., Kwon, O. J., Laguardia, L., Lahtinen, A., Laing, A., Lalousis, P., Lam, N., Lamb, C., Lambertz, H. T., Lang, P. T., Lanthaler, S., Neto, E. Lascas, Laszynska, E., Lawless, R., Lawson, K. D., Lazaros, A., Lazzaro, E., Leach, R., Learoyd, G., Leerink, S., Lefebvre, X., Leggate, H. J., Lehmann, J., Lehnen, M., Leichauer, P., Leichtle, D., Leipold, F., Lengar, I, Lennholm, M., Lepiavko, B., Leppanen, J., Lerche, E., Lescinskis, A., Lescinskis, B., Lesnoj, S., Leyland, M., Leysen, W., Li, Y., Li, L., Liang, Y., Likonen, J., Linke, J., Linsmeier, Ch, Lipschultz, B., Litaudon, X., Liu, G., Lloyd, B., Lo Schiavo, V. P., Loarer, T., Loarte, A., Lomanowski, B., Lomas, P. J., Lonnroth, J., Lopez, J. M., Lorenzini, R., Losada, U., Loughlin, M., Lowry, C., Luce, T., Lucock, R., Lukin, A., Luna, C., Lungaroni, M., Lungu, C. P., Lungu, M., Lunniss, A., Lunt, T., Lupelli, I, Lutsenko, V, Lyssoivan, A., Macheta, P., Macusova, E., Magesh, B., Maggi, C., Maggiora, R., Mahesan, S., Maier, H., Mailloux, J., Maingi, R., Makwana, R., Malaquias, A., Malinowski, K., Malizia, A., Manas, P., Manduchi, G., Manso, M. E., Mantica, P., Mantsinen, M., Manzanares, A., Maquet, Ph, Marandet, Y., Marcenko, N., Marchetto, C., Marchuk, O., Marconato, N., Mariani, A., Marin, M., Marinelli, M., Marinucci, M., Markovic, T., Marocco, D., Marot, L., Marsh, J., Martin, A., Martin de Aguilera, A., Martin-Solis, J. R., Martone, R., Martynova, Y., Maruyama, S., Maslov, M., Matejcik, S., Mattei, M., Matthews, G. F., Matveev, D., Matveeva, E., Mauriya, A., Maviglia, F., May-Smith, T., Mayer, M., Mayoral, M. L., Mazon, D., Mazzotta, C., Mcadams, R., Mccarthy, P. J., Mcclements, K. G., Mccormack, O., Mccullen, P. A., Mcdonald, D., Mchardy, M., Mckean, R., Mckehon, J., Mcnamee, L., Meadowcroft, C., Meakins, A., Medley, S., Meigh, S., Meigs, A. 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C., Siren, P., Sirinelli, A., Sjostrand, H., Skiba, M., Skilton, R., Skvara, V, Slade, B., Smith, R., Smith, P., Smith, S. F., Snoj, L., Soare, S., Solano, E. R., Somers, A., Sommariva, C., Sonato, P., Sos, M., Sousa, J., Sozzi, C., Spagnolo, S., Sparapani, P., Spelzini, T., Spineanu, F., Sprada, D., Sridhar, S., Stables, G., Stallard, J., Stamatelatos, I, Stamp, M. F., Stan-Sion, C., Stancar, Z., Staniec, P., Stankunas, G., Stano, M., Stavrou, C., Stefanikova, E., Stepanov, I, Stephen, A., Stephen, M., Stephens, J., Stevens, B., Stober, J., Stokes, C., Strachan, J., Strand, P., Strauss, H. R., Strom, P., Studholme, W., Subba, F., Suchkov, E., Summers, H. P., Sun, H., Sutton, N., Svensson, J., Sytnykov, D., Szabolics, T., Szepesi, G., Suzuki, T. 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D., Zerbini, M., Zhang, W., Zhou, Y., Zilli, E., Zocco, A., Zoita, V, Zoletnik, S., Zwingmann, W., Zychor, I, Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Max-Planck-Institut für Plasmaphysik [Garching] (IPP), Jet Contributors, European Project: 633053,H2020,EURATOM-Adhoc-2014-20,EUROfusion(2014), Garcia, J, Doerk, H, Gorler, T, Abduallev, S, Abhangi, M, Abreu, P, Afanasev, V, Afzal, M, Aggarwal, Km, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Alarcon, T, Albanese, R, Alegre, D, Aleiferis, S, Alessi, E, Aleynikov, P, Alkseev, A, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amosov, V, Sunden, Ea, Andrews, R, Angelone, M, Anghel, M, Angioni, C, Appel, L, Appelbee, C, Arena, P, Ariola, M, Arshad, S, Artaud, J, Arter, W, Ash, A, Ashikawa, N, Aslanyan, V, Asunta, O, Asztalos, O, Auriemma, F, Austin, Y, Avotina, L, Axton, M, Ayres, C, Baciero, A, Baiao, D, Balboa, I, Balden, M, 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Maslov, M, Matejcik, S, Mattei, M, Matthews, Gf, Matveev, D, Matveeva, E, Mauriya, A, Maviglia, F, May-Smith, T, Mayer, M, Mayoral, Ml, Mazon, D, Mazzotta, C, Mcadams, R, Mccarthy, Pj, Mcclements, Kg, Mccormack, O, Mccullen, Pa, Mcdonald, D, Mchardy, M, Mckean, R, Mckehon, J, Mcnamee, L, Meadowcroft, C, Meakins, A, Medley, S, Meigh, S, Meigs, Ag, Meisl, G, Meiter, S, Meitner, S, Meneses, L, Menmuir, S, Mergia, K, Merle, A, Merriman, P, Mertens, P, Meshchaninov, S, Messiaen, A, Meyer, H, Michling, R, Milanesio, D, Militello, F, Militello-Asp, E, Milocco, A, Miloshevsky, G, Mink, F, Minucci, S, Miron, I, Mistry, S, Miyoshi, Y, Mlynar, J, Moiseenko, V, Monaghan, P, Monakhov, I, Moon, S, Mooney, R, Moradi, S, Morales, J, Moran, J, Mordijck, S, Moreira, L, Moro, F, Morris, J, Moser, L, Mosher, S, Moulton, D, Mrowetz, T, Muir, A, Muraglia, M, Murari, A, Muraro, A, Murphy, S, Muscat, P, Muthusonai, N, Myers, C, Asakura, Nn, N'Konga, B, Nabais, F, Naish, R, Naish, J, Nakano, T, Napoli, F, Nardon, E, Naulin, V, Nave, Mff, Nedzelskiy, I, Nemtsev, G, Nesenevich, V, Nespoli, F, Neto, A, Neu, R, Neverov, V, Newman, M, Ng, S, Nicassio, M, Nielsen, Ah, Nina, D, Nishijima, D, Noble, C, Nobs, Cr, Nocente, M, Nodwell, D, Nordlund, K, Nordman, H, Normanton, R, Noterdaeme, Jm, Nowak, S, Nunes, I, O'Gorman, T, O'Mullane, M, Oberkofler, M, Oberparleiter, M, Odupitan, T, Ogawa, Mt, Okabayashi, M, Oliver, H, Olney, R, Omoregie, L, Ongena, J, Orsitto, F, Orszagh, J, Osborne, T, Otin, R, Owen, A, Owen, T, Paccagnella, R, Packer, Lw, Pajuste, E, Pamela, S, Panja, S, Papp, P, Papp, G, Parail, V, Pardanaud, C, Diaz, Fp, Parsloe, A, Parsons, N, Parsons, M, Pasqualotto, R, Passeri, M, Patel, A, Pathak, S, Patten, H, Pau, A, Pautasso, G, Pavlichenko, R, Pavone, A, Pawelec, E, Soldan, Cp, Peackoc, A, Pehkonen, Sp, Peluso, E, Penot, C, Penzo, J, Pepperell, K, Pereira, R, Cippo, Ep, von Thun, Cp, Pericoli, V, Peruzzo, S, Peterka, M, Petersson, P, Petravich, G, Petre, A, Petrzilka, V, Philipps, V, Pigatto, L, Pillon, M, Pinches, S, Pintsuk, G, Piovesan, P, de Sa, Wp, dos Reis, Ap, Piron, L, Piron, C, Pironti, A, Pisano, F, Pitts, R, Plyusnin, V, Poli, Fm, Pomaro, N, Pompilian, Og, Pool, P, Popovichev, S, Poradzinski, M, Porfiri, Mt, Porosnicu, C, Porton, M, Possnert, G, Potzel, S, Poulipoulis, G, Powell, T, Prajapati, V, Prakash, R, Predebon, I, Prestopino, G, Price, D, Price, M, Price, R, Primetzhofer, D, Prior, P, Pucella, G, Puglia, P, Puiatti, Me, Purahoo, K, Pusztai, I, Putterich, T, Rachlew, E, Rack, M, Ragona, R, Rainford, M, Raj, P, Rakha, A, Ramogida, G, Ranjan, S, Rapson, Cj, Rasmussen, D, Rasmussen, Jj, Rathod, K, Ratta, G, Ratynskaia, S, Ravera, G, Rebai, M, Reed, A, Refy, D, Regana, J, Reich, M, Reid, N, Reimold, F, Reinhart, M, Reinke, M, Reiser, D, Rendell, D, Reux, C, Cortes, Sdar, Reynolds, S, Ricci, D, Richiusa, M, Rigamonti, D, Rimini, Fg, Risner, J, Riva, M, Rivero-Rodriguez, J, Roach, C, Robins, R, Robinson, S, Robson, D, Rodionov, R, Rodrigues, P, 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I, Vadgama, A, Valcarcel, D, Vale, R, Valentinuzzi, M, Valerii, K, Valisa, M, Olivares, Pv, Valovic, M, Van Eester, D, Van Renterghem, W, van Rooij, Gj, Varje, J, Vartanian, S, Vasava, K, Vasilopoulou, T, Vecsei, M, Vega, J, Ventre, S, Verdoolaege, G, Verona, C, Rinati, Gv, Veshchev, E, Vianello, N, Vicente, J, Viezzer, E, Villari, S, Villone, F, Vincent, M, Vincenzi, P, Vinyar, I, Viola, B, Vitins, A, Vizvary, Z, Vlad, M, Voitsekhovitch, I, Voltolina, D, von Toussaint, U, Vondracek, P, Vuksic, M, Wakeling, B, Waldon, C, Walkden, N, Walker, R, Walker, M, Walsh, M, Wang, N, Wang, E, Warder, S, Warren, R, Waterhouse, J, Watts, C, Wauters, T, Webb, M, Weckmann, A, Weiland, J, Weiland, M, Weisen, H, Weiszflog, M, Welch, P, West, A, Wheatley, M, Wheeler, S, Whitehead, Am, Whittaker, D, Widdowson, Am, Wiesen, S, Wilkie, G, Williams, J, Willoughby, D, Wilson, J, Wilson, I, Wilson, Hr, Wischmeier, M, Withycombe, A, Witts, D, Wolfrum, E, Wood, R, Woodley, R, Woodley, C, Wray, S, Wright, Jc, Wright, P, Wukitch, S, Wynn, A, Xiang, L, Xu, T, Xue, Y, Yadikin, D, Yakovenko, Y, Yanling, W, Yavorskij, V, Young, I, Young, R, Young, D, Zacks, J, Zagorski, R, Zaitsev, F, Zakharov, L, Zanino, R, Zarins, A, Zarins, R, Fernandez, Dz, Zastrow, Kd, Zerbini, M, Zhang, W, Zhou, Y, Zilli, E, Zocco, A, Zoita, V, Zoletnik, S, Zwingmann, W, Zychor, I, and JET Contributors
Subjects: Tokamak, Plasma turbulence, Extrapolation, turbulence, transport, plasma, JET, 7. Clean energy, 01 natural sciences, 010305 fluids & plasmas, law.invention, law, Physics::Plasma Physics, jet, 0103 physical sciences, 010306 general physics, plasma, Physics, Shearing (physics), [PHYS]Physics [physics], Turbulence, Plasma, Mechanics, JET, Condensed Matter Physics, Nuclear Energy and Engineering, Pinch
Abstract: See also: Plasma Physics and Controlled Fusion, 61, 104002 (2019)Special Issue on the 2018 Joint Varenna-Lausanne International Workshop on the Theory of Fusion Plasmas; International audience; Developing successful tokamak operation scenarios, as well as confident extrapolation of present-day knowledge requires a rigorous understanding of plasma turbulence, which largely determines the quality of the confinement. In particular, accurate particle transport predictions are essential due to the strong dependence of fusion power or bootstrap current on the particle density details. Here, gyrokinetic turbulence simulations are performed with physics inputs taken from a JET power scan, for which a relatively weak degradation of energy confinement and a significant density peaking is obtained with increasing input power. This way physics parameters that lead to such increase in the density peaking shall be elucidated. While well-known candidates, such as the collisionality, previously found in other studies are also recovered in this study, it is furthermore found that edge $E×B$ shearing may adopt a crucial role by enhancing the inward pinch. These results may indicate that a plasma with rotational shear could develop a stronger density peaking as compared to a non-rotating one, because its inward convection is increased compared to the outward diffusive particle flux as long as this rotation has a significant on $E$X$B$ flow shear stabilisation. The possibly significant implications for future devices, which will exhibit much less torque compared to present day experiments, are discussed.
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7. AMD and Stem Cell-Based Therapies.

Author: Giacalone JC, Parkinson DH, Balikov DA, and Rao RC
Subjects: Humans, Stem Cell Transplantation, Retinal Pigment Epithelium
Abstract: Competing Interests: The authors declare that they have no conflicts of interest to disclose.
Published: 2024
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8. Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration.

Author: Mulfaul K, Mullin NK, Giacalone JC, Voigt AP, R DeVore M, Stone EM, Tucker BA, and Mullins RF
Subjects: Choroid metabolism, Complement Membrane Attack Complex metabolism, Complement Membrane Attack Complex pharmacology, Endothelial Cells metabolism, Humans, Retinal Pigment Epithelium metabolism, Complement Factor H genetics, Macular Degeneration genetics, Macular Degeneration pathology
Abstract: Activation of the alternative complement pathway is an initiating event in the pathology of age-related macular degeneration (AMD). Unchecked complement activation leads to the formation of a pro-lytic pore, the membrane attack complex (MAC). MAC deposition is observed on the choriocapillaris of AMD patients and likely causes lysis of choroidal endothelial cells (CECs). Complement factor H (FH, encoded by the gene CFH) is an inhibitor of complement. Both loss of function of FH and reduced choroidal levels of FH have been reported in AMD. It is plausible that reduced local FH availability promotes MAC deposition on CECs. FH is produced primarily in the liver; however, cells including the retinal pigment epithelium can produce FH locally. We hypothesized that CECs produce FH locally to protect against MAC deposition. We aimed to investigate the effect of reduced FH levels in the choroid to determine whether increasing local FH could protect CECs from MAC deposition. We demonstrated that siRNA knockdown of FH (CFH) in human immortalized CECs results in increased MAC deposition. We generated AMD iPSC-derived CECs and found that overexpression of FH protects against MAC deposition. These results suggest that local CEC-produced FH protects against MAC deposition, and that increasing local FH protein may be beneficial in limiting MAC deposition in AMD. © 2022 The Pathological Society of Great Britain and Ireland., (© 2022 The Pathological Society of Great Britain and Ireland.)
Published: 2022
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9. Label-free microfluidic enrichment of photoreceptor cells.

Author: Stone NE, Voigt AP, Cooke JA, Giacalone JC, Hanasoge S, Mullins RF, Tucker BA, and Sulchek T
Subjects: Animals, Cell Differentiation, Cell Line, Humans, Microscopy, Atomic Force, Photoreceptor Cells metabolism, Retinal Degeneration metabolism, Retinal Pigment Epithelium metabolism, Microfluidics methods, Photoreceptor Cells pathology, Retinal Degeneration diagnosis, Retinal Pigment Epithelium pathology
Abstract: Inherited retinal degenerative disorders such as retinitis pigmentosa and Usher syndrome are characterized by progressive death of photoreceptor cells. To restore vision to patients blinded by these diseases, a stem cell-based photoreceptor cell replacement strategy will likely be required. Although retinal stem cell differentiation protocols suitable for generating photoreceptor cells exist, they often yield a rather heterogenous mixture of cell types. To enrich the donor cell population for one or a few cell types, scientists have traditionally relied upon the use of antibody-based selection approaches. However, these strategies are quite labor intensive and require animal derived reagents and equipment that are not well suited to current good manufacturing practices (cGMP). The purpose of this study was to develop and evaluate a microfluidic cell sorting device capable of exploiting the physical and mechanical differences between retinal cell types to enrich specific donor cell populations such as Retinal Pigment Epithelial (RPE) cells and photoreceptor cells. Using this device, we were able to separate a mixture of RPE and iPSC-derived photoreceptor precursor cell lines into two substantially enriched fractions. The enrichment factor of the RPE fraction was 2 and that of the photoreceptor precursor cell fraction was 2.7. Similarly, when human retina, obtained from 3 independent donors, was dissociated and passed through the sorting device, the heterogeneous mixture could be reliably sorted into RPE and photoreceptor cell rich fractions. In summary, microfluidic cell sorting is a promising approach for antibody free enrichment of retinal cell populations., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
Published: 2020
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10. Stepwise differentiation and functional characterization of human induced pluripotent stem cell-derived choroidal endothelial cells.

Author: Mulfaul K, Giacalone JC, Voigt AP, Riker MJ, Ochoa D, Han IC, Stone EM, Mullins RF, and Tucker BA
Subjects: Cell Differentiation, Cells, Cultured, Choroid, Endothelial Cells, Endothelium, Humans, Induced Pluripotent Stem Cells
Abstract: Background: Endothelial cells (ECs) are essential regulators of the vasculature, lining arteries, veins, and capillary beds. While all ECs share a number of structural and molecular features, heterogeneity exists depending on their resident tissue. ECs lining the choriocapillaris in the human eye are lost early in the pathogenesis of age-related macular degeneration (AMD), a common and devastating form of vision loss. In order to study the mechanisms leading to choroidal endothelial cell (CEC) loss and to develop reagents for repairing the choroid, a reproducible in vitro model, which closely mimic CECs, is needed. While a number of protocols have been published to direct induced pluripotent stem cells (iPSCs) into ECs, the goal of this study was to develop methods to differentiate iPSCs into ECs resembling those found in the human choriocapillaris specifically., Methods: We transduced human iPSCs with a CDH5p-GFP-ZEO lentiviral vector and selected for transduced iPSCs using blasticidin. We generated embryoid bodies (EBs) from expanded iPSC colonies and transitioned from mTESR™1 to EC media. One day post-EB formation, we induced mesoderm fate commitment via addition of BMP-4, activin A, and FGF-2. On day 5, EBs were adhered to Matrigel-coated plates in EC media containing vascular endothelial cell growth factor (VEGF) and connective tissue growth factor (CTGF) to promote CEC differentiation. On day 14, we selected for CECs using either zeocin resistance or anti-CD31 MACS beads. We expanded CECs post-selection and performed immunocytochemical analysis of CD31, carbonic anhydrase IV (CA4), and RGCC; tube formation assays; and transmission electron microscopy to access vascular function., Results: We report a detailed protocol whereby we direct iPSC differentiation toward mesoderm and utilize CTGF to specify CECs. The CDH5p-GFP-ZEO lentiviral vector facilitated the selection of iPSC-derived ECs that label with antibodies directed against CD31, CA4, and RGCC; form vascular tubes in vitro; and migrate into empty choroidal vessels. CECs selected using either antibiotic selection or CD31 MACS beads showed similar characteristics, thereby making this protocol easily reproducible with or without lentiviral vectors., Conclusion: ECs generated following this protocol exhibit functional and biochemical characteristics of CECs. This protocol will be useful for developing in vitro models toward understanding the mechanisms of CEC loss early in AMD.
Published: 2020
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11. Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype.

Author: Voigt AP, Whitmore SS, Mulfaul K, Chirco KR, Giacalone JC, Flamme-Wiese MJ, Stockman A, Stone EM, Tucker BA, Scheetz TE, and Mullins RF
Subjects: Age Factors, Aged, Aged, 80 and over, Aging metabolism, Female, Gene Expression Regulation, Humans, Infant, Infant, Newborn, Inflammation metabolism, Macular Degeneration metabolism, Male, Middle Aged, Phenotype, Aging genetics, Choroid blood supply, Endothelial Cells metabolism, Inflammation genetics, Inflammation Mediators metabolism, Macular Degeneration genetics, Sequence Analysis, RNA, Single-Cell Analysis
Abstract: The human choroidal vasculature is subject to age-related structural and gene expression changes implicated in age-related macular degeneration (AMD). In this study, we performed both bulk and single-cell RNA sequencing on infant (n = 4 for bulk experiments, n = 2 for single-cell experiments) and adult (n = 13 for bulk experiments, n = 6 for single-cell experiments) human donors to characterize how choroidal gene expression changes with age. Differential expression analysis revealed that aged choroidal samples were enriched in genes encoding pro-inflammatory transcription factors and leukocyte transendothelial cell migration adhesion proteins. Such genes were observed to be differentially expressed specifically within choroidal endothelial cells at the single-cell level. Immunohistochemistry experiments support transcriptional findings that CD34 is elevated in infant choriocapillaris endothelial cells while ICAM-1 is enriched in adults. These results suggest several potential drivers of the pro-inflammatory vascular phenotype observed with advancing age., (Copyright © 2020 Elsevier Inc. All rights reserved.)
Published: 2020
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12. Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration.

Author: Voigt AP, Mulfaul K, Mullin NK, Flamme-Wiese MJ, Giacalone JC, Stone EM, Tucker BA, Scheetz TE, and Mullins RF
Subjects: Choroid cytology, Choroid pathology, Epithelial Cells metabolism, Epithelium metabolism, Humans, Retina cytology, Retina pathology, Single-Cell Analysis, Choroid metabolism, Macular Degeneration metabolism, Retina metabolism, Transcriptome
Abstract: The human retinal pigment epithelium (RPE) and choroid are complex tissues that provide crucial support to the retina. Disease affecting either of these supportive tissues can lead to irreversible blindness in the setting of age-related macular degeneration. In this study, single-cell RNA sequencing was performed on macular and peripheral regions of RPE-choroid from 7 human donor eyes in 2 independent experiments. In the first experiment, total RPE/choroid preparations were evaluated and expression profiles specific to RPE and major choroidal cell populations were identified. As choroidal endothelial cells represent a minority of the total RPE/choroidal cell population but are strongly implicated in age-related macular degeneration (AMD) pathogenesis, a second single-cell RNA-sequencing experiment was performed using endothelial cells enriched by magnetic separation. In this second study, we identified gene expression signatures along the choroidal vascular tree, classifying the transcriptome of human choriocapillaris, arterial, and venous endothelial cells. We found that the choriocapillaris highly and specifically expresses the regulator of cell cycle gene ( RGCC ), a gene that responds to complement activation and induces apoptosis in endothelial cells. In addition, RGCC was the most up-regulated choriocapillaris gene in a donor diagnosed with AMD. These results provide a characterization of the human RPE and choriocapillaris transcriptome, offering potential insight into the mechanisms of choriocapillaris response to complement injury and choroidal vascular disease in age-related macular degeneration., Competing Interests: The authors declare no competing interest., (Copyright © 2019 the Author(s). Published by PNAS.)
Published: 2019
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13. Development of a Molecularly Stable Gene Therapy Vector for the Treatment of RPGR -Associated X-Linked Retinitis Pigmentosa.

Author: Giacalone JC, Andorf JL, Zhang Q, Burnight ER, Ochoa D, Reutzel AJ, Collins MM, Sheffield VC, Mullins RF, Han IC, Stone EM, and Tucker BA
Subjects: Alleles, Amino Acid Substitution, Base Sequence, Dependovirus genetics, Exons, Gene Expression, Gene Order, Genetic Variation, Genetic Vectors administration & dosage, Humans, Male, Open Reading Frames, Plasmids genetics, Retinitis Pigmentosa metabolism, Retinitis Pigmentosa therapy, Sequence Analysis, DNA, Transgenes, Eye Proteins genetics, Genes, X-Linked, Genetic Therapy methods, Genetic Vectors genetics, Mutation, Retinitis Pigmentosa genetics
Abstract: In a screen of 1,000 consecutively ascertained families, we recently found that mutations in the gene RPGR are the third most common cause of all inherited retinal disease. As the two most frequent disease-causing genes, ABCA4 and USH2A , are far too large to fit into clinically relevant adeno-associated virus (AAV) vectors, RPGR is an obvious early target for AAV-based ocular gene therapy. In generating plasmids for this application, we discovered that those containing wild-type RPGR sequence, which includes the highly repetitive low complexity region ORF15, were extremely unstable ( i.e. , they showed consistent accumulation of genomic changes during plasmid propagation). To develop a stable RPGR gene transfer vector, we used a bioinformatics approach to identify predicted regions of genomic instability within ORF15 ( i.e. , potential non-B DNA conformations). Synonymous substitutions were made in these regions to reduce the repetitiveness and increase the molecular stability while leaving the encoded amino acid sequence unchanged. The resulting construct was subsequently packaged into AAV serotype 5, and the ability to drive transcript expression and functional protein production was demonstrated via subretinal injection in rat and pull-down assays, respectively. By making synonymous substitutions within the repetitive region of RPGR , we were able to stabilize the plasmid and subsequently generate a clinical-grade gene transfer vector (IA-RPGR). Following subretinal injection in rat, we demonstrated that the augmented transcript was expressed at levels similar to wild-type constructs. By performing in vitro pull-down experiments, we were able to show that IA-RPGR protein product retained normal protein binding properties ( i.e. , analysis revealed normal binding to PDE6D, INPP5E, and RPGRIP1L). In summary, we have generated a stable RPGR gene transfer vector capable of producing functional RPGR protein, which will facilitate safety and toxicity studies required for progression to an Investigational New Drug application.
Published: 2019
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14. Generation of an immortalized human choroid endothelial cell line (iChEC-1) using an endothelial cell specific promoter.

Author: Giacalone JC, Miller MJ, Workalemahu G, Reutzel AJ, Ochoa D, Whitmore SS, Stone EM, Tucker BA, and Mullins RF
Subjects: Antigens, Viral, Tumor genetics, Antigens, Viral, Tumor metabolism, Biomarkers metabolism, Cell Line, Endothelial Cells immunology, Endothelial Cells metabolism, Female, Gene Expression Regulation, Genotype, Humans, Immunomagnetic Separation, Infant, Newborn, Macular Degeneration metabolism, Macular Degeneration pathology, Macular Degeneration physiopathology, Neovascularization, Physiologic, Phenotype, Platelet Endothelial Cell Adhesion Molecule-1 immunology, Platelet Endothelial Cell Adhesion Molecule-1 metabolism, Telomerase genetics, Telomerase metabolism, Transfection, Antigens, CD genetics, Cadherins genetics, Choroid blood supply, Endothelial Cells physiology, Promoter Regions, Genetic
Abstract: Age-related macular degeneration (AMD) is a common cause of blindness worldwide. While recent studies have revealed that the loss of choroidal endothelial cells (ChECs) is critical to the disease pathogenesis of dry AMD, in vitro studies are needed to fully elucidate the disease mechanism. However, these studies remain hindered due to the lack of publically available human ChEC lines. To address this need, ChECs were harvested form donor tissue and enriched for by using magnetic cell separation using anti-CD31 conjugated microbeads. Next, lenti-viral vectors with endothelial-specific promoters driving genes necessary for immortalization, CDH5p-hTERT and CDH5p TAg, were generated. Stable integration of both gene cassettes allowed cells to maintain their proliferative state and yielded an immortalized cell line (iChEC-1). Immunocytochemical analysis of iChEC-1 confirmed the expression of important ChEC markers such as CA4, a marker of choriocapillaris endothelial cells, CDH5, and CD34, pan-endothelial cell markers. qRT-PCR analysis of expanded clones from iChEC-1 further showed that the line maintained expression of other important endothelial markers, vWF, PECAM1, and PLVAP, similar to primary cells. Functional responses were characterized by tube-forming assays and repopulation of decellularized choroid with the immortalized cell line. In conclusion, the iChEC-1 line presents a suitable immortalized human ChEC line for future in vitro studies of AMD., (Copyright © 2018. Published by Elsevier Inc.)
Published: 2019
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15. Correction of NR2E3 Associated Enhanced S-cone Syndrome Patient-specific iPSCs using CRISPR-Cas9.

Author: Bohrer LR, Wiley LA, Burnight ER, Cooke JA, Giacalone JC, Anfinson KR, Andorf JL, Mullins RF, Stone EM, and Tucker BA
Subjects: CRISPR-Cas Systems genetics, Cell Differentiation genetics, Codon, Nonsense genetics, Eye Diseases, Hereditary pathology, Gene Expression Regulation, Developmental genetics, Genetic Predisposition to Disease, Humans, Induced Pluripotent Stem Cells metabolism, Induced Pluripotent Stem Cells transplantation, Mutation, Orphan Nuclear Receptors therapeutic use, Retinal Degeneration pathology, Retinal Rod Photoreceptor Cells metabolism, Retinal Rod Photoreceptor Cells pathology, Vision Disorders pathology, Eye Diseases, Hereditary genetics, Eye Diseases, Hereditary therapy, Genetic Therapy, Orphan Nuclear Receptors genetics, Retinal Degeneration genetics, Retinal Degeneration therapy, Vision Disorders genetics, Vision Disorders therapy
Abstract: Enhanced S-cone syndrome (ESCS) is caused by recessive mutations in the photoreceptor cell transcription factor NR2E3 . Loss of NR2E3 is characterized by repression of rod photoreceptor cell gene expression, over-expansion of the S-cone photoreceptor cell population, and varying degrees of M- and L-cone photoreceptor cell development. In this study, we developed a CRISPR-based homology-directed repair strategy and corrected two different disease-causing NR2E3 mutations in patient-derived induced pluripotent stem cells (iPSCs) generated from two affected individuals. In addition, one patient's iPSCs were differentiated into retinal cells and NR2E3 transcription was evaluated in CRISPR corrected and uncorrected clones. The patient's c.119-2A>C mutation caused the inclusion of a portion of intron 1, the creation of a frame shift, and generation of a premature stop codon. In summary, we used a single set of CRISPR reagents to correct different mutations in iPSCs generated from two individuals with ESCS. In doing so we demonstrate the advantage of using retinal cells derived from affected patients over artificial in vitro model systems when attempting to demonstrate pathophysiologic mechanisms of specific mutations.
Published: 2019
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16. Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP.

Author: Zhang Q, Giacalone JC, Searby C, Stone EM, Tucker BA, and Sheffield VC
Subjects: Animals, Binding Sites genetics, Cell Line, Cilia genetics, HEK293 Cells, Humans, Mice, Protein Isoforms genetics, Eye Proteins genetics, Mutation, Missense genetics, Nuclear Proteins genetics, Protein Interaction Domains and Motifs genetics, Retinitis Pigmentosa genetics
Abstract: Retinitis pigmentosa (RP) is an inherited retinal degenerative disease with severe vision impairment leading to blindness. About 10-15% of RP cases are caused by mutations in the RPGR gene, with RPGR mutations accounting for 70% of X-linked RP cases. The mechanism by which RPGR mutations cause photoreceptor cell dysfunction is not well understood. In this study, we show that the two isoforms of RPGR (RPGR 1-19 and RPGR ORF15 ) interact with endogenous PDE6D, INPP5E, and RPGRIP1L. The RPGR 1-19 isoform contains two PDE6D binding sites with the C-terminal prenylation site being the predominant PDE6D binding site. The C terminus of RPGR 1-19 that contains the prenylation site regulates its interaction with PDE6D, INPP5E, and RPGRIP1L. Only the RPGR 1-19 isoform localizes to cilia in cultured RPE1 cells. Missense variations found in RPGR patients disrupt the interaction between RPGR isoforms and their endogenous interactors INPP5E, PDE6D, and RPGRIP1L. We evaluated a RPGR missense variation (M58K) found in a family with X-linked retinitis pigmentosa (XLRP) and show that this missense variation disrupts the interaction of RPGR isoforms with their endogenous interactors. The M58K variation also disrupts the ciliary localization of the RPGR 1-19 isoform. Using this assay, we also show that some of the RPGR missense variants reported in the literature might not actually be disease causing. Our data establishes an in vitro assay that can be used to validate the potential pathogenicity of RPGR missense variants., Competing Interests: The authors declare no conflict of interest.
Published: 2019
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17. Visible spectroscopy diagnostics for tungsten source assessment in the WEST tokamak: First measurements.

Author: Meyer O, Giacalone JC, Gouin A, Pascal JY, Klepper CC, Fedorczak N, Lotte P, Unterberg EA, Fehling DT, and Harris JH
Abstract: The present work concerns the measurements obtained with the Tungsten (W) Environment in Steady-state Tokamak (WEST) visible spectroscopy system during the first experimental campaign. This system has been developed in the framework of the WEST project that equipped the existing Tore Supra device with a tungsten divertor in order to test actively cooled tungsten Plasma Facing Components (PFC) in view of preparing for ITER operation. The goal of this diagnostic is to measure the PFC sources and the deuterium recycling with spectral, spatial, and temporal resolution adapted to the predicted power deposition profiles on the objects observed. Three kinds of PFCs are monitored: the Ion Cyclotron Resonance Heating (ICRH) antenna and Low Hybrid Current Drive (LHCD) launcher W limiters; one of the 6 W inner bumpers; and the upper and lower W divertors. Large-aperture in-vessel actively cooled optical systems (f-number ∼ 3) were installed for each view and connected to optical fibres. A total of 240 optical fibers can be distributed on various detection systems including a fast response-time, multi-channel, filtered photodetector-based "Filterscope" system, developed by Oak Ridge National Laboratory (USA) as well as grating spectrometers optimized for multi-sightline analysis. The first WEST experimental campaign conducted in 2017 has been dedicated to plasma start-up development during which the visible spectroscopy system has provided crucial information related to the impurity content first and then impurity sources. The diagnostic setup for that first experimental campaign was limited to the inner bumper and outer limiters but was sufficient to demonstrate that the optical setup was in accordance with the specifications. The radiance calibration procedure allowed us to estimate fluxes from the main limiter of about 8 × 10 18 atoms/(s m 2 ) and to show a first W source radial profile along the outboard limiter.
Published: 2018
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18. CRISPR-Cas9 genome engineering: Treating inherited retinal degeneration.

Author: Burnight ER, Giacalone JC, Cooke JA, Thompson JR, Bohrer LR, Chirco KR, Drack AV, Fingert JH, Worthington KS, Wiley LA, Mullins RF, Stone EM, and Tucker BA
Subjects: Animals, Humans, Induced Pluripotent Stem Cells, Retinal Degeneration genetics, CRISPR-Cas Systems genetics, Gene Editing methods, Genetic Therapy methods, Retinal Degeneration therapy, Stem Cell Transplantation
Abstract: Gene correction is a valuable strategy for treating inherited retinal degenerative diseases, a major cause of irreversible blindness worldwide. Single gene defects cause the majority of these retinal dystrophies. Gene augmentation holds great promise if delivered early in the course of the disease, however, many patients carry mutations in genes too large to be packaged into adeno-associated viral vectors and some, when overexpressed via heterologous promoters, induce retinal toxicity. In addition to the aforementioned challenges, some patients have sustained significant photoreceptor cell loss at the time of diagnosis, rendering gene replacement therapy insufficient to treat the disease. These patients will require cell replacement to restore useful vision. Fortunately, the advent of induced pluripotent stem cell and CRISPR-Cas9 gene editing technologies affords researchers and clinicians a powerful means by which to develop strategies to treat patients with inherited retinal dystrophies. In this review we will discuss the current developments in CRISPR-Cas9 gene editing in vivo in animal models and in vitro in patient-derived cells to study and treat inherited retinal degenerative diseases., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
Published: 2018
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19. CRISPR-Cas9-Based Genome Editing of Human Induced Pluripotent Stem Cells.

Author: Giacalone JC, Sharma TP, Burnight ER, Fingert JF, Mullins RF, Stone EM, and Tucker BA
Subjects: Electroporation, Humans, Recombination, Genetic genetics, CRISPR-Associated Protein 9 metabolism, CRISPR-Cas Systems genetics, Gene Editing methods, Genome, Human, Induced Pluripotent Stem Cells metabolism
Abstract: Human induced pluripotent stem cells (hiPSCs) are the ideal cell source for autologous cell replacement. However, for patients with Mendelian diseases, genetic correction of the original disease-causing mutation is likely required prior to cellular differentiation and transplantation. The emergence of the CRISPR-Cas9 system has revolutionized the field of genome editing. By introducing inexpensive reagents that are relatively straightforward to design and validate, it is now possible to correct genetic variants or insert desired sequences at any location within the genome. CRISPR-based genome editing of patient-specific iPSCs shows great promise for future autologous cell replacement therapies. One caveat, however, is that hiPSCs are notoriously difficult to transfect, and optimized experimental design considerations are often necessary. This unit describes design strategies and methods for efficient CRISPR-based genome editing of patient- specific iPSCs. Additionally, it details a flexible approach that utilizes positive selection to generate clones with a desired genomic modification, Cre-lox recombination to remove the integrated selection cassette, and negative selection to eliminate residual hiPSCs with intact selection cassettes. © 2018 by John Wiley & Sons, Inc., (Copyright © 2018 John Wiley & Sons, Inc.)
Published: 2018
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20. CRISPR-Cas9-Mediated Correction of the 1.02 kb Common Deletion in CLN3 in Induced Pluripotent Stem Cells from Patients with Batten Disease.

Author: Burnight ER, Bohrer LR, Giacalone JC, Klaahsen DL, Daggett HT, East JS, Madumba RA, Worthington KS, Mullins RF, Stone EM, Tucker BA, and Wiley LA
Abstract: Juvenile neuronal ceroid lipofuscinosis (Batten disease) is a rare progressive neurodegenerative disorder caused by mutations in CLN3 . Patients present with early-onset retinal degeneration, followed by epilepsy, progressive motor deficits, cognitive decline, and premature death. Approximately 85% of individuals with Batten disease harbor at least one allele containing a 1.02 kb genomic deletion spanning exons 7 and 8. This study demonstrates CRISPR-Cas9-based homology-dependent repair of this mutation in induced pluripotent stem cells generated from two independent patients: one homozygous and one compound heterozygous for the 1.02 kb deletion. Our strategy included delivery of a construct that carried >3 kb of DNA: wild-type CLN3 sequence and a LoxP-flanked, puromycin resistance cassette for positive selection. This strategy resulted in correction at the genomic DNA and mRNA levels in the two independent patient lines. These CRISPR-corrected isogenic cell lines will be a valuable tool for disease modeling and autologous retinal cell replacement.
Published: 2018
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21. Clinically Focused Molecular Investigation of 1000 Consecutive Families with Inherited Retinal Disease.

Author: Stone EM, Andorf JL, Whitmore SS, DeLuca AP, Giacalone JC, Streb LM, Braun TA, Mullins RF, Scheetz TE, Sheffield VC, and Tucker BA
Subjects: Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, DNA Mutational Analysis, Exome genetics, Family Health, Female, Genetic Testing, Genotype, High-Throughput Nucleotide Sequencing, Humans, Infant, Male, Middle Aged, Pedigree, Retrospective Studies, Sensitivity and Specificity, Sequence Analysis, DNA, United States, Eye Diseases, Hereditary genetics, Eye Proteins genetics, Mutation, Retinal Diseases genetics
Abstract: Purpose: To devise a comprehensive multiplatform genetic testing strategy for inherited retinal disease and to describe its performance in 1000 consecutive families seen by a single clinician., Design: Retrospective series., Participants: One thousand consecutive families seen by a single clinician., Methods: The clinical records of all patients seen by a single retina specialist between January 2010 and June 2016 were reviewed, and all patients who met the clinical criteria for a diagnosis of inherited retinal disease were included in the study. Each patient was assigned to 1 of 62 diagnostic categories, and this clinical diagnosis was used to define the scope and order of the molecular investigations that were performed. The number of nucleotides evaluated in a given subject ranged from 2 to nearly 900 000., Main Outcome Measures: Sensitivity and false genotype rate., Results: Disease-causing genotypes were identified in 760 families (76%). These genotypes were distributed across 104 different genes. More than 75% of these 104 genes have coding sequences small enough to be packaged efficiently into an adeno-associated virus. Mutations in ABCA4 were the most common cause of disease in this cohort (173 families), whereas mutations in 80 genes caused disease in 5 or fewer families (i.e., 0.5% or less). Disease-causing genotypes were identified in 576 of the families without next-generation sequencing (NGS). This included 23 families with mutations in the repetitive region of RPGR exon 15 that would have been missed by NGS. Whole-exome sequencing of the remaining 424 families revealed mutations in an additional 182 families, and whole-genome sequencing of 4 of the remaining 242 families revealed 2 additional genotypes that were invisible by the other methods. Performing the testing in a clinically focused tiered fashion would be 6.1% more sensitive and 17.7% less expensive and would have a significantly lower average false genotype rate than using whole-exome sequencing to assess more than 300 genes in all patients (7.1% vs. 128%; P < 0.001)., Conclusions: Genetic testing for inherited retinal disease is now more than 75% sensitive. A clinically directed tiered testing strategy can increase sensitivity and improve statistical significance without increasing cost., (Copyright © 2017 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)
Published: 2017
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22. Choosing surgery as a career: Early results of a longitudinal study of medical students.

Author: Berger AP, Giacalone JC, Barlow P, Kapadia MR, and Keith JN
Subjects: Career Mobility, Clinical Clerkship, Education, Medical, Undergraduate methods, Female, Humans, Logistic Models, Longitudinal Studies, Male, Multivariate Analysis, Socioeconomic Factors, Students, Medical statistics & numerical data, Young Adult, Career Choice, Specialties, Surgical education
Abstract: Background: Few studies have explored the factors associated with the preference of medical students to pursue a specific specialty, and even fewer have observed how these preferences and factors change over time., Methods: A longitudinal survey of medical students was administered at the beginning of first year, second year, and clerkships from 2013-2016. Surveys included demographics and factors associated with their choice of specialty., Results: Response rates were 78-94%. Students with mentors and research experience in any specialty were 3.4 times (P < .001) more likely to choose surgery by their third year of medical school. Surgical research experience on the first- and second-year surveys was associated with 39 (P < .001) and 10 times (P < .001) greater odds of preferring surgical specialties on their third-year survey. Medical students who had a surgery mentor during the first and second years were associated with 4 (P = .024) and 13 times (P < .001) greater odds of preferring surgical specialties on their third-year survey., Conclusion: Students who begin surgical research during their first year and develop relationships with surgeon mentors during their second year are significantly more likely to maintain an interest in surgical specialties., (Copyright © 2016 Elsevier Inc. All rights reserved.)
Published: 2017
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23. Connective Tissue Growth Factor Promotes Efficient Generation of Human Induced Pluripotent Stem Cell-Derived Choroidal Endothelium.

Author: Songstad AE, Worthington KS, Chirco KR, Giacalone JC, Whitmore SS, Anfinson KR, Ochoa D, Cranston CM, Riker MJ, Neiman M, Stone EM, Mullins RF, and Tucker BA
Subjects: Animals, Cell Differentiation, Cells, Cultured, Cellular Reprogramming Techniques methods, Choroid physiology, Connective Tissue Growth Factor pharmacology, Endothelial Cells drug effects, Endothelium cytology, Endothelium physiology, Haplorhini, Humans, Induced Pluripotent Stem Cells drug effects, Regeneration, Stem Cell Transplantation methods, Choroid cytology, Endothelial Cells cytology, Induced Pluripotent Stem Cells cytology, Macular Degeneration therapy
Abstract: Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the Western world. Although, the majority of stem cell research to date has focused on production of retinal pigment epithelial (RPE) and photoreceptor cells for the purpose of evaluating disease pathophysiology and cell replacement, there is strong evidence that the choroidal endothelial cells (CECs) that form the choriocapillaris vessels are the first to be lost in this disease. As such, to accurately evaluate disease pathophysiology and develop an effective treatment, production of patient-specific, stem cell-derived CECs will be required. In this study, we report for the first time a stepwise differentiation protocol suitable for generating human iPSC-derived CEC-like cells. RNA-seq analysis of the monkey CEC line, RF/6A, combined with two statistical screens allowed us to develop media comprised of various protein combinations. In both screens, connective tissue growth factor (CTGF) was identified as the key component required for driving CEC development. A second factor tumor necrosis factor (TNF)-related weak inducer of apoptosis receptor was also found to promote iPSC to CEC differentiation by inducing endogenous CTGF secretion. CTGF-driven iPSC-derived CEC-like cells formed capillary tube-like vascular networks, and expressed the EC-specific markers CD31, ICAM1, PLVAP, vWF, and the CEC-restricted marker CA4. In combination with RPE and photoreceptor cells, patient-specific iPSC derived CEC-like cells will enable scientists to accurately evaluate AMD pathophysiology and develop effective cell replacement therapies. Stem Cells Translational Medicine 2017;6:1533-1546., (© 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.)
Published: 2017
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24. Development of visible spectroscopy diagnostics for W sources assessment in WEST.

Author: Meyer O, Jones OM, Giacalone JC, Pascal JY, Raulin D, Xu H, Aumeunier MH, Baude R, Escarguel A, Gil C, Harris JH, Hatchressian JC, Klepper CC, Larroque S, Lotte P, Moreau P, Pégourié B, and Vartanian S
Abstract: The present work concerns the development of a W sources assessment system in the framework of the tungsten-W environment in steady state tokamak project that aims at equipping the existing Tore Supra device with a tungsten divertor in order to test actively cooled tungsten Plasma Facing Components (PFCs) in view of preparing ITER operation. The goal is to assess W sources and D recycling with spectral, spatial, and temporal resolution adapted to the PFCs observed. The originality of the system is that all optical elements are installed in the vacuum vessel and compatible with steady state operation. Our system is optimized to measure radiance as low as 10 16 Ph/(m 2 s sr). A total of 240 optical fibers will be deployed to the detection systems such as the "Filterscope," developed by Oak Ridge National Laboratory (USA) and consisting of photomultiplier tubes and filters, or imaging spectrometers dedicated to Multiview analysis.
Published: 2016
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25. Concise Review: Patient-Specific Stem Cells to Interrogate Inherited Eye Disease.

Author: Giacalone JC, Wiley LA, Burnight ER, Songstad AE, Mullins RF, Stone EM, and Tucker BA
Subjects: Animals, Blindness metabolism, Blindness pathology, Cell Differentiation, Disease Models, Animal, Glaucoma metabolism, Glaucoma pathology, Humans, Induced Pluripotent Stem Cells cytology, Induced Pluripotent Stem Cells physiology, Leber Congenital Amaurosis metabolism, Leber Congenital Amaurosis pathology, Macular Degeneration metabolism, Macular Degeneration pathology, Precision Medicine, Retina metabolism, Retina pathology, Retinitis Pigmentosa metabolism, Retinitis Pigmentosa pathology, Stem Cell Transplantation, Transplantation, Autologous, Blindness prevention & control, Glaucoma therapy, Induced Pluripotent Stem Cells transplantation, Leber Congenital Amaurosis therapy, Macular Degeneration therapy, Retinitis Pigmentosa therapy
Abstract: Whether we are driving to work or spending time with loved ones, we depend on our sense of vision to interact with the world around us. Therefore, it is understandable why blindness for many is feared above death itself. Heritable diseases of the retina, such as glaucoma, age-related macular degeneration, and retinitis pigmentosa, are major causes of blindness worldwide. The recent success of gene augmentation trials for the treatment of RPE65-associated Leber congenital amaurosis has underscored the need for model systems that accurately recapitulate disease. With the advent of patient-specific induced pluripotent stem cells (iPSCs), researchers are now able to obtain disease-specific cell types that would otherwise be unavailable for molecular analysis. In the present review, we discuss how the iPSC technology is being used to confirm the pathogenesis of novel genetic variants, interrogate the pathophysiology of disease, and accelerate the development of patient-centered treatments. Significance: Stem cell technology has created the opportunity to advance treatments for multiple forms of blindness. Researchers are now able to use a person's cells to generate tissues found in the eye. This technology can be used to elucidate the genetic causes of disease and develop treatment strategies. In the present review, how stem cell technology is being used to interrogate the pathophysiology of eye disease and accelerate the development of patient-centered treatments is discussed., (©AlphaMed Press.)
Published: 2016
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26. Prospective, multicenter study of ventricular assist device infections.

Author: Gordon RJ, Weinberg AD, Pagani FD, Slaughter MS, Pappas PS, Naka Y, Goldstein DJ, Dembitsky WP, Giacalone JC, Ferrante J, Ascheim DD, Moskowitz AJ, Rose EA, Gelijns AC, and Lowy FD
Subjects: Adult, Aged, Cardiovascular Infections epidemiology, Cardiovascular Infections microbiology, Creatinine blood, Depression epidemiology, Female, Gram-Negative Bacterial Infections microbiology, Heart Failure therapy, Humans, Incidence, Male, Middle Aged, Risk Factors, Severity of Illness Index, Treatment Outcome, Gram-Negative Bacterial Infections epidemiology, Heart-Assist Devices microbiology, Prosthesis-Related Infections epidemiology, Prosthesis-Related Infections microbiology, Pseudomonas Infections epidemiology, Staphylococcal Infections epidemiology
Abstract: Background: Ventricular assist devices (VADs) improve survival and quality of life in patients with advanced heart failure, but their use is frequently complicated by infection. There are limited data on the microbiology and epidemiology of these infections., Methods and Results: One hundred fifty patients scheduled for VAD implantation were enrolled (2006-2008) at 11 US cardiac centers and followed prospectively until transplantation, explantation for recovery, death, or for 1 year. Eighty-six patients (57%) received HeartMate II devices. Data were collected on potential preoperative, intraoperative, and postoperative risk factors for infection. Clinical, laboratory, and microbiological data were collected for suspected infections and evaluated by an infectious diseases specialist. Thirty-three patients (22%) developed 34 VAD-related infections with an incidence rate of 0.10 per 100 person-days (95% confidence interval, 0.073-0.142). The median time to infection was 68 days. The driveline was the most commonly infected site (n=28); 18 (64%) were associated with invasive disease. Staphylococci were the most common pathogen (47%), but pseudomonas or other Gram-negative bacteria caused 32% of infections. A history of depression and elevated baseline serum creatinine were independent predictors of VAD infection (adjusted hazard ratio=2.8 [P=0.007] and 1.7 [P=0.023], respectively). The HeartMate II was not associated with a decreased risk of infection. VAD infection increased 1-year mortality (adjusted hazard ratio=5.6; P<0.0001)., Conclusions: This prospective, multicenter study demonstrates that infection frequently complicates VAD placement and is a continuing problem despite the use of newer, smaller devices. Depression and renal dysfunction may increase the risk of VAD infection. VAD infection is a serious consequence because it adversely affects patient survival., Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01471795.
Published: 2013
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27. Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia.

Author: Horani A, Druley TE, Zariwala MA, Patel AC, Levinson BT, Van Arendonk LG, Thornton KC, Giacalone JC, Albee AJ, Wilson KS, Turner EH, Nickerson DA, Shendure J, Bayly PV, Leigh MW, Knowles MR, Brody SL, Dutcher SK, and Ferkol TW
Subjects: Adult, Axonemal Dyneins, Child, Chlamydomonas reinhardtii genetics, Chromosome Disorders genetics, Chromosome Disorders metabolism, Epithelial Cells metabolism, Female, Genes, Recessive, Genetic Predisposition to Disease, Humans, Infant, Kartagener Syndrome metabolism, Male, Respiratory System metabolism, Sequence Analysis, DNA methods, Young Adult, Exome, Kartagener Syndrome genetics, Mutation, Missense, Proteins genetics
Abstract: Motile cilia are essential components of the mucociliary escalator and are central to respiratory-tract host defenses. Abnormalities in these evolutionarily conserved organelles cause primary ciliary dyskinesia (PCD). Despite recent strides characterizing the ciliome and sensory ciliopathies through exploration of the phenotype-genotype associations in model organisms, the genetic bases of most cases of PCD remain elusive. We identified nine related subjects with PCD from geographically dispersed Amish communities and performed exome sequencing of two affected individuals and their unaffected parents. A single autosomal-recessive nonsynonymous missense mutation was identified in HEATR2, an uncharacterized gene that belongs to a family not previously associated with ciliary assembly or function. Airway epithelial cells isolated from PCD-affected individuals had markedly reduced HEATR2 levels, absent dynein arms, and loss of ciliary beating. MicroRNA-mediated silencing of the orthologous gene in Chlamydomonas reinhardtii resulted in absent outer dynein arms, reduced flagellar beat frequency, and decreased cell velocity. These findings were recapitulated by small hairpin RNA-mediated knockdown of HEATR2 in airway epithelial cells from unaffected donors. Moreover, immunohistochemistry studies in human airway epithelial cells showed that HEATR2 was localized to the cytoplasm and not in cilia, which suggests a role in either dynein arm transport or assembly. The identification of HEATR2 contributes to the growing number of genes associated with PCD identified in both individuals and model organisms and shows that exome sequencing in family studies facilitates the discovery of novel disease-causing gene mutations., (Copyright © 2012 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.)
Published: 2012
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28. Staphylococcus epidermidis colonization is highly clonal across US cardiac centers.

Author: Gordon RJ, Miragaia M, Weinberg AD, Lee CJ, Rolo J, Giacalone JC, Slaughter MS, Pappas P, Naka Y, Tector AJ, de Lencastre H, and Lowy FD
Subjects: Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents pharmacology, Bacterial Typing Techniques, Electrophoresis, Gel, Pulsed-Field, Female, Humans, Male, Microbial Sensitivity Tests, Middle Aged, Multilocus Sequence Typing methods, Prospective Studies, Specimen Handling, Staphylococcal Infections epidemiology, Staphylococcus epidermidis drug effects, United States epidemiology, Young Adult, Heart-Assist Devices microbiology, Methicillin Resistance drug effects, Staphylococcal Infections microbiology, Staphylococcus epidermidis classification
Abstract: Background: Little is known about the clonality of Staphylococcus epidermidis in the United States, although it is the predominant pathogen in infections involving prosthetic materials, including ventricular assist devices (VADs)., Methods: Seventy-five VAD recipients at 4 geographically diverse US cardiac centers were prospectively followed up to 1 year of VAD support. The anterior nares, sternum, and (future) driveline exit site were cultured for S. epidermidis before VAD insertion and at 7 times after surgery. Infection isolates were also collected. Isolates were typed by pulsed-field gel electrophoresis. A subset underwent susceptibility testing and staphylococcal chromosomal cassette mec and multilocus sequence typing., Results: A total of 1559 cultures yielded 565 S. epidermidis isolates; 254 of 548 typed isolates (46%) belonged to 1 of 7 clonal types as defined by pulsed-field gel electrophoresis. These clones were identified in up to 27 people distributed across all 4 cardiac centers. They caused 3 of 6 VAD-related infections. Disseminated clones were more antibiotic resistant than were less prevalent isolates (eg, 79% vs 54% methicillin resistant; P = .0021)., Conclusions: This study revealed that healthcare-associated S. epidermidis infection is remarkably clonal. We describe S. epidermidis clones that are highly resistant to antibiotics distributed across US cardiac centers. These clones may have determinants that enhance transmissibility, persistence, or invasiveness. Clinical Trials Registration. NCT01471795.
Published: 2012
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28 results on '"Giacalone, JC"'

1. Overview of JET results for optimising ITER operation

2. First principles and integrated modelling achievements towards trustful fusion power predictions for JET and ITER

3. Adaptive learning for disruption prediction in non-stationary conditions

4. Role of fast ion pressure in the isotope effect in JET L-mode plasmas

5. Ion cyclotron resonance heating scenarios for DEMO

6. A new mechanism for increasing density peaking in tokamaks: improvement of the inward particle pinch with edge E x B shearing

7. AMD and Stem Cell-Based Therapies.

8. Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration.

9. Label-free microfluidic enrichment of photoreceptor cells.

10. Stepwise differentiation and functional characterization of human induced pluripotent stem cell-derived choroidal endothelial cells.

11. Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype.

12. Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration.

13. Development of a Molecularly Stable Gene Therapy Vector for the Treatment of RPGR -Associated X-Linked Retinitis Pigmentosa.

14. Generation of an immortalized human choroid endothelial cell line (iChEC-1) using an endothelial cell specific promoter.

15. Correction of NR2E3 Associated Enhanced S-cone Syndrome Patient-specific iPSCs using CRISPR-Cas9.

16. Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP.

17. Visible spectroscopy diagnostics for tungsten source assessment in the WEST tokamak: First measurements.

18. CRISPR-Cas9 genome engineering: Treating inherited retinal degeneration.

19. CRISPR-Cas9-Based Genome Editing of Human Induced Pluripotent Stem Cells.

20. CRISPR-Cas9-Mediated Correction of the 1.02 kb Common Deletion in CLN3 in Induced Pluripotent Stem Cells from Patients with Batten Disease.

21. Clinically Focused Molecular Investigation of 1000 Consecutive Families with Inherited Retinal Disease.

22. Choosing surgery as a career: Early results of a longitudinal study of medical students.

23. Connective Tissue Growth Factor Promotes Efficient Generation of Human Induced Pluripotent Stem Cell-Derived Choroidal Endothelium.

24. Development of visible spectroscopy diagnostics for W sources assessment in WEST.

25. Concise Review: Patient-Specific Stem Cells to Interrogate Inherited Eye Disease.

26. Prospective, multicenter study of ventricular assist device infections.

27. Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia.

28. Staphylococcus epidermidis colonization is highly clonal across US cardiac centers.

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