Search

Your search keyword '"Ghose, Ritobrata"' showing total 11 results
Start Over Author "Ghose, Ritobrata"
11 results on '"Ghose, Ritobrata"'

3. A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability

Author

Moretton, Amandine, Kourtis, Savvas, Gañez Zapater, Antoni, Calabrò, Chiara, Espinar Calvo, Maria Lorena, Fontaine, Frédéric, Darai, Evangelia, Abad Cortel, Etna, Block, Samuel, Pascual‐Reguant, Laura, Pardo‐Lorente, Natalia, Ghose, Ritobrata, Vander Heiden, Matthew G, Janic, Ana, Müller, André C, Loizou, Joanna I, and Sdelci, Sara

Published
2023
Full Text
View/download PDF

8. From research to rapid response: mass COVID-19 testing by volunteers at the Centre for Genomic Regulation

Author

Ghose, Ritobrata, primary, Aranguren-Ibáñez, Álvaro, additional, Arecco, Niccolò, additional, Balboa, Diego, additional, Bataller, Marc, additional, Beltran, Sergi, additional, Benisty, Hannah, additional, Bénard, Angèle, additional, Bernardo, Edgar, additional, Carbonell Sala, Sílvia, additional, Casals, Eloi, additional, Ciampi, Ludovica, additional, Condemi, Livia, additional, Corvó, Alberto, additional, Cosín-Tomás, Marta, additional, Cuenca-Ardura, Mirabai, additional, Duran Serrano, Juan Manuel, additional, Espejo Díaz, María Isabel, additional, Fernandez Callejo, Marcos, additional, Gañez-Zapater, Antoni, additional, Garcia-Castellanos, Raquel, additional, Garrido, Romina, additional, Henkin, Gil, additional, Hermoso Pulido, Toni, additional, Hernandez-Alias, Xavier, additional, Herrero Vicente, Jorge, additional, Ingham, Matthew, additional, Lim, Wei Ming, additional, Llonch, Sílvia, additional, Marmesat Bertoli, Elena, additional, Miguel-Escalada, Irene, additional, Montero-Blay, Ariadna, additional, Navarrete Hernández, Cristina, additional, Neguembor, Maria Victoria, additional, Ní Chárthaigh, Róisín-Ana, additional, Pardo-Lorente, Natalia, additional, Pascual-Reguant, Laura, additional, Pérez-Lluch, Sílvia, additional, Perza, Reyes, additional, Pesaresi, Martina, additional, Picó Amador, Daniel, additional, Pifarré, Paula, additional, Piscia, Davide, additional, Plana-Carmona, Marcos, additional, Ponomarenko, Julia, additional, Radusky, Leandro, additional, Rivero, Ezequiel, additional, Rogalska, Malgorzata, additional, Torcal Garcia, Guillem, additional, and Wojnacki, José, additional

Published
2020
Full Text
View/download PDF

10. Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number

Author

Katsanos, Dimitris, primary, Koneru, Sneha L., additional, Mestek Boukhibar, Lamia, additional, Gritti, Nicola, additional, Ghose, Ritobrata, additional, Appleford, Peter J., additional, Doitsidou, Maria, additional, Woollard, Alison, additional, van Zon, Jeroen S., additional, Poole, Richard J., additional, and Barkoulas, Michalis, additional

Published
2017
Full Text
View/download PDF

11. A role for the fusogen eff-1 in epidermal stem cell number robustness in Caenorhabditis elegans

Author

Koneru, Sneha L., Quah, Fu Xiang, Ghose, Ritobrata, Hintze, Mark, Gritti, Nicola, Sebastiaan van Zon, Jeroen, Barkoulas, Michalis, Koneru, Sneha L., Quah, Fu Xiang, Ghose, Ritobrata, Hintze, Mark, Gritti, Nicola, Sebastiaan van Zon, Jeroen, and Barkoulas, Michalis

Abstract

Developmental patterning in Caenorhabditis elegans is known to proceed in a highly stereotypical manner, which raises the question of how developmental robustness is achieved despite the inevitable stochastic noise. We focus here on a population of epidermal cells, the seam cells, which show stem cell-like behaviour and divide symmetrically and asymmetrically over post-embryonic development to generate epidermal and neuronal tissues. We have conducted a mutagenesis screen to identify mutants that introduce phenotypic variability in the normally invariant seam cell population. We report here that a null mutation in the fusogen eff-1 increases seam cell number variability. Using time-lapse microscopy and single molecule fluorescence hybridisation, we find that seam cell division and differentiation patterns are mostly unperturbed in eff-1 mutants, indicating that cell fusion is uncoupled from the cell differentiation programme. Nevertheless, seam cell losses due to the inappropriate differentiation of both daughter cells following division, as well as seam cell gains through symmetric divisions towards the seam cell fate were observed at low frequency. We show that these stochastic errors likely arise through accumulation of defects interrupting the continuity of the seam and changing seam cell shape, highlighting the role of tissue homeostasis in suppressing phenotypic variability during development.

Catalog

Books, media, physical & digital resources
See catalog results