Background and Objectives: Metabolic syndrome (MetS) is a cluster of interrelated metabolic risk factors. The most widely-recognized set of these risk factors are: increase in waist circumference (abdominal obesity), elevated blood pressure, elevated triglycerides, growth in serum glucose and reduction in high density lipoproteins. There have been various definitions for the diagnosis of MetS, but those which introduced by the International Diabetes Federation (IDF) and the Adult Treatment Panel (ATP III) are more widely implemented because they do not require measurement of insulin resistant. Based on the definition offered by ATP III, if a person has three of the aforementioned factors, he/she has MetS. MetS directly increased cardiovascular disease and diabetes. The cardiovascular diseases, diabetes and obesity are the major health challenges in the 21st century. Therefore, attention to this disease must be much greater than in the past due to its prevalence in the current century. Studies show that various factors affect MetS, the most important ones are age and body weight. Studies have also shown that lack of physical activities, alcohol consumption, unhealthy food habits and smoking increase occurrence of MetS. Gender, race, Body Mass Index (BMI) and prolonged sitting at work are among other factors affecting MetS. Various studies have reported different prevalence rates of this syndrome. The global prevalence of MetS varies from 10 to 50 percent. According to IDF, one-fourth of adults in the world are suffering from MetS and among them, the risk of death and chances of a stroke and heart attack are two and three times higher, respectively. The estimated rate for Iran is 34.4 percent, whereas (according to the ACEP criteria) 20 percent of the general population in the United States suffer from MetS. MetS is considered as an important health challenge because of its costs on healthcare systems and furthermore due to its high socioeconomic costs. Studies show that the average annual costs per person in the US is estimated at $ 4,000 for treating this syndrome. Workers are an important component of any organization, and workplace directly affects worker’s physical, mental and social condition; there for workplace is a very critical environmental and social factor affecting worker’s health. Up to now few studies with small sample size have been carried out on the prevalence of MetS in industrial workplace in Iran. Since identification of the risk factors related to MetS can play an important Role in the worker’s health and consequently increase industrial productivity, it is necessary to carry out a thorough and comprehensive study on a large sample population of the Iranian workers in order identify and control this syndrome and its related risk factors. The purpose of this study was to investigate the prevalence of metabolic syndrome and its effective demographic factors among workers in one of the petrochemical industries. Materials and Methods: The following cross sectional study was conducted among 692 male workers of a petrochemical company in south-west Iran. All participants had at least one-year work experience without any history of congenital disease, heart failure, kidney problem or hypertension. Stratified random sampling method was used to select participants. The procedure and aims of the study were explained to the participants and they were assured that their personal information will be kept confidential. Also all participants signed an informed written consent form prior to their participation. A data was collected by a two-part questionnaire in this study. The first part was focused on demographic information (age, marital status, education, and smoking status) and included questions on inclusion and exclusion criteria, the second part collected anthropometric information (height, weight, and waist circumference), blood pressure, and the parameters obtained through performing blood tests and BMI values (BMI obtained through dividing body weight in kilograms by height in meters squared). Based on criteria defined by World Health Organization, the BMI values were classified into four groups: less than 18.5 (underweight), 18.5-24.9 (normal range), 25-29.9 (overweight), and higher than 30 (obese). Since few participants had BMI values lower than 18.5, the BMI values of underweight participants and the BMI values in the normal range were categorized into one group. The participant's blood pressure was measured by a standard mercury manometer. Each participant’s blood pressure was measured twice in a sitting position on the right arm, with a 5-minute rest between the two measurements, also each participant was asked to sit down for at least five minutes and then their blood pressure was measured. The first part of the questionnaire was answered by the participants, then their anthropomorphic information and their blood pressure were measured by a researcher. After that they were asked to visit the laboratory to have their blood samples taken (after fasting for 12-14 hours). Three markers from the blood sample tests were recorded: fasting blood sugar, triglycerides and HDL-C. After blood samples were taken, tests to measure fasting plasma glucose and triglycerides levels were carried out using the enzymatic colorimetric method, employing Pars Azmoon standard kits. HDL cholesterol tests were performed employing the antibody-enzyme method and using Pars Azmoon standard kits. Adult Treatment Panel III (ATP III) method was used to diagnose MetS in the study population. MetS was diagnosed based on abdominal obesity, increased blood pressure, increased triglycerides, low HDL cholesterol level, and increased fasting blood sugar. Based on the ATP III method the copresence of at least three of the following indicators is considered diagnostic for MetS: waist circumference ≥ 102 cm in men and ≥ 88 cm in women, triglycerides level ≥ 150 mg/dl, HDL level ≤40mg/dl in men and ≤50 mg/dl in women, systolic blood pressure ≥130.85 mm Hg, diastolic pressure ≥85 mm Hg and fasting blood sugar ≥ 100mg/dl. Using SPSS version 24, descriptive statistics were analyzed. Mean, percentage, range and standard deviation were calculated. In order to determine correlation between MetS and its factors with shift work odds ratio (ORs) for the MetS, 95% confidence level (95% CL), chi-square test, Spearman correlation test and logistic regression analysis were performed. To assess the effect of shift work on NCEP ATP III factors and demographic factors, independent samples t test and Cramer's V were implemented. The level of statistical significance for p-value was set at 0.05). A significant difference between mean values of body mass index, high-density lipoprotein, shift work, waist circumference, triglycerides, blood pressure and plasma glucose was identified among people diagnosed with metabolic syndrome and healthy individuals (p