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1. First Ex-Vivo Validation of a Radioguided Surgery Technique with beta- Radiation

Author

Camillocci, E. Solfaroli, Schiariti, M., Bocci, V., Carollo, A., Chiodi, G., Colandrea, M., Collamati, F., Cremonesi, M., Donnarumma, R., Ferrari, M. E., Ferroli, P., Ghielmetti, F., Grana, C. M., Marafini, M., Morganti, S., Terracciano, C. Mancini, Patanè, M., Pedroli, G., Pollo, B., Recchia, L., Russomando, A., Toppi, M., Traini, G., and Faccini, R.

Subjects
Physics - Instrumentation and Detectors, Physics - Medical Physics
Abstract

Purpose: A radio-guided surgery technique with beta- -emitting radio-tracers was suggested to overcome the effect of the large penetration of gamma radiation. The feasibility studies in the case of brain tumors and abdominal neuro-endocrine tumors were based on simulations starting from PET images with several underlying assumptions. This paper reports, as proof-of-principle of this technique, an ex-vivo test on a meningioma patient. This test allowed to validate the whole chain, from the evaluation of the SUV of the tumor, to the assumptions on the bio-distribution and the signal detection. Methods: A patient affected by meningioma was administered 300 MBq of 90Y-DOTATOC. Several samples extracted from the meningioma and the nearby Dura Mater were analyzed with a beta- probe designed specifically for this radio-guided surgery technique. The observed signals were compared both with the evaluation from the histology and with the Monte Carlo simulation. Results: we obtained a large signal on the bulk tumor (105 cps) and a significant signal on residuals of $\sim$0.2 ml (28 cps). We also show that simulations predict correctly the observed yields and this allows us to estimate that the healthy tissues would return negligible signals (~1 cps). This test also demonstrated that the exposure of the medical staff is negligible and that among the biological wastes only urine has a significant activity. Conclusions: This proof-of-principle test on a patient assessed that the technique is feasible with negligible background to medical personnel and confirmed that the expectations obtained with Monte Carlo simulations starting from diagnostic PET images are correct., Comment: 17 pages, 4 Figs, Accepted by Physica Medica

Published
2016
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2. Radio-Guided Surgery with β − Radiation: Tests on Ex-Vivo Specimens

Author

Mancini-Terracciano, C., Bocci, V., Colandrea, M., Collamati, F., Cremonesi, M., Faccini, R., Ferrari, M. E., Ferroli, P., Ghielmetti, F., Grana, C. M., Marafini, M., Morganti, S., Papi, S., Patané, M., Pedroli, G., Pollo, B., Russomando, A., Schiariti, M., Traini, G., Solfaroli Camillocci, E., Magjarevic, Ratko, Editor-in-Chief, Ładyżyński, Piotr, Series Editor, Ibrahim, Fatimah, Series Editor, Lacković, Igor, Series Editor, Rock, Emilio Sacristan, Series Editor, Lhotska, Lenka, editor, Sukupova, Lucie, editor, and Ibbott, Geoffrey S., editor

Published
2019
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8. The Spectral Line Shape of Exotic Nuclei

Author

Ghielmetti, F., Colò, G., Vigezzi, E., Bortignon, P. F., and Broglia, R. A.

Subjects
Nuclear Theory
Abstract

The quadrupole strength function of $^{28}O$ is calculated making use of the SIII interaction, within the framework of continuum-RPA and taking into account collisions among the nucleons (doorway coupling). The centroid of the giant resonance is predicted at $\approx 14$ MeV, that is much below the energy expected for both isoscalar and isovector quadrupole resonances in nuclei along the stability valley. About half of this width arises from the coupling of the resonance to the continuum and about half is due to doorway coupling. This result is similar to that obtained in the study of giant resonances in light, $\beta$-stable nuclei, and shows the lack of basis for the expectation, entertained until now in the literature, that continuum decay was the main damping mechanism of giant resonances in halo nuclei., Comment: LaTeX file, 7 pages, figures not included but available if requested at colo@mi.infn.it, accepted for publication in Phys. Rev. C

Published
1996
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12. Radio-Guided Surgery with β− Radiation: Tests on Ex-Vivo Specimens

Author

Mancini-Terracciano, C., primary, Bocci, V., additional, Colandrea, M., additional, Collamati, F., additional, Cremonesi, M., additional, Faccini, R., additional, Ferrari, M. E., additional, Ferroli, P., additional, Ghielmetti, F., additional, Grana, C. M., additional, Marafini, M., additional, Morganti, S., additional, Papi, S., additional, Patané, M., additional, Pedroli, G., additional, Pollo, B., additional, Russomando, A., additional, Schiariti, M., additional, Traini, G., additional, and Solfaroli Camillocci, E., additional

Published
2018
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14. Multisession radiosurgery for intracranial meningioma treatment: Study protocol of a single arm, monocenter, prospective trial

Author

Pinzi, V, Marchetti, M, De Martin, E, Cuccarini, V, Tramacere, I, Ghielmetti, F, Fumagalli, M, Iezzoni, C, Fariselli, L, Pinzi V., Marchetti M., De Martin E., Cuccarini V., Tramacere I., Ghielmetti F., Fumagalli M. L., Iezzoni C., Fariselli L., Pinzi, V, Marchetti, M, De Martin, E, Cuccarini, V, Tramacere, I, Ghielmetti, F, Fumagalli, M, Iezzoni, C, Fariselli, L, Pinzi V., Marchetti M., De Martin E., Cuccarini V., Tramacere I., Ghielmetti F., Fumagalli M. L., Iezzoni C., and Fariselli L.

Abstract

Background: Single session radiosurgery represents a widely accepted treatment for intracranial meningiomas. However, this approach could involve a high risk of treatment-related complications when applied to large volume lesions. In these cases and for those not suitable for surgical resection, radiosurgery in multisession setting could represents a viable option. The literature results are reassuring in terms of correlated adverse events as well as in terms of tumor control. However, no prospective long-term results are available. In this scenario, we design a prospective monocentric phase II study, in order to verify the safety of a multisession radiosurgery schedule delivering 25 Gy in 5 daily fractions. Methods: Patients diagnosed with large and/or near to critical structures, intracranial meningiomas have been treated by means of multisession radiosurgery in both exclusive and postoperative settings. The primary study aim is safety that has been being prospectively scored based on international scales, including NCI Common Toxicity criteria, version 4.03, Barrow Neurological Institute pain intensity score, Barrow Neurological Institute facial numbness score and House-Brackmann Facial Nerve Grading System for qualitative analysis. Secondary aim is treatment efficacy in terms of local control that has been being assessed on volumetric analysis. Discussion: This is the first prospective phase II trial on multisession radiosurgery for large and/or near to critical structures intracranial meningiomas. If positive results will be found, this study could represent the starting point for a phase III trial exploring the role of multisession radiosurgery in the exclusive and postoperative radiation therapy treatment of intracranial meningiomas.

Published
2020

17. Radiosurgery for trigeminal neuralgia: the state of art

Author

Marchetti, M, Pinzi, V, De Martin, E, Ghielmetti, F, Fariselli, L, Marchetti M., Pinzi V., De Martin E., Ghielmetti F., Fariselli L., Marchetti, M, Pinzi, V, De Martin, E, Ghielmetti, F, Fariselli, L, Marchetti M., Pinzi V., De Martin E., Ghielmetti F., and Fariselli L.

Abstract

The trigeminal neuralgia (TN) is a chronic, episodic, and disabling facial pain syndrome. It is a relatively rare disorder. Despite this, because of the intensity of the pain, TN may have a dramatic impact for many patients. Fortunately, most of the patients may obtain a good pain relief simply by taking drugs. Historically, the surgical approaches represent a true treatment paradigm for all the drug-resistant TN. In this context, radiosurgery (RS) is a relatively new treatment modality. The effectiveness and safety of radiosurgery are today widely accepted and the technique can be proposed to many patients which suffer from a drug-resistant TN. This is true especially when the patients are less than ideal candidates for an open surgery, or for elderly ones, when a clear neuro-vascular conflict is not evident. The present review provides a concise analysis of the actual indications for radiosurgery, as well as the most acknowledged prognostic factors. The pathogenesis of TN and the rationale for the RS efficacy are also investigated and described. Some technical aspects including the target selection and the prescription doses, which have widely changed in time, are depicted. In conclusion, the present review supports the idea that TN is a complex disease and radiosurgery represents an effective and relatively new treatment modality, which enriches the treatment armamentarium for these unfortunate patients. To optimize the RS results, a correct patient selection has to be performed.

Published
2019

19. Radiosurgery for Paragangliomas of the Head and Neck: Another Step for the Validation of a Treatment Paradigm

Author

Marchetti, M, Pinzi, V, Tramacere, I, Bianchi, L, Ghielmetti, F, Fariselli, L, Marchetti M., Pinzi V., Tramacere I., Bianchi L. C., Ghielmetti F., Fariselli L., Marchetti, M, Pinzi, V, Tramacere, I, Bianchi, L, Ghielmetti, F, Fariselli, L, Marchetti M., Pinzi V., Tramacere I., Bianchi L. C., Ghielmetti F., and Fariselli L.

Abstract

Background Paragangliomas are highly vascular and predominantly benign neoplasms that traditionally have been treated by surgery, embolization, and/or external beam radiotherapy. The aim of this study was to evaluate long-term local tumor control and the safety of radiosurgery for head and neck paragangliomas. Methods Data were obtained from prospectively maintained databases of patients affected by brain tumors treated with radiosurgery at our institution. The inclusion criteria were histologically proven or radiologic-suspected diagnosis of paragangliomas; a follow-up period of at least 12 months, an magnetic resonance imaging–based tumor growth control analysis and a signed written consent. Twenty patients (21 paragangliomas) met the eligibility criteria and were included in the present study. All patients were clinically and radiologically evaluated before and after treatment. Results The mean follow-up at the time of the present analysis was 46 months. Seven patients had a follow-up longer than 60 months. Seven lesions underwent a single-session radiosurgery with a mean dose of 12.2 Gy (range 11–13 Gy). Fourteen lesions underwent multisession radiosurgery with a mean dose of 25.7 Gy (range 20–30 Gy) delivered in 3–5 fractions. The mean tumor volume for single-session radiosurgery was 4 cc (range 1.4–9.2). The mean volume for multisession radiosurgery was 18.9 cc (range 1.3–50.9). None of the lesions showed progression on radiology during the follow-up period. Neurologic conditions generally are maintained or improved. Conclusions Both single and multisession radiosurgery were confirmed as a safe and effective treatment modality for paragangliomas. Multisession radiosurgery appears effective to treat large lesions.

Published
2017

22. The β - radio-guided surgery: Method to estimate the minimum injectable activity from ex-vivo test

Author

Russomando, A., Schiariti, M., Bocci, V., Colandrea, M., Collamati, F., Cremonesi, M., Ferrari, M. E., Ferroli, P., Ghielmetti, F., Ghisini, R., Grana, C. M., Mancini Terracciano, C., Marafini, M., Mirabelli, R., Morganti, S., Papi, S., Patanè, M., Pedroli, G., Pollo, B., Solfaroli Camillocci, E., Traini, G., and Faccini, R.

Subjects
Brain tumours, Biophysics, Radio-guided-surgery, Octreotide, Radiation Dosage, β - decays, Injections, Beta Particles, Physics and Astronomy (all), Computer-Assisted, Occupational Exposure, Positron-Emission Tomography, Nuclear Medicine and Imaging, Humans, Surgery, Yttrium Radioisotopes, Intraoperative imaging, Meningioma, Radiology, Surgery, Computer-Assisted, Radiology, Nuclear Medicine and Imaging
Published
2019

26. The β- radio-guided surgery: Method to estimate the minimum injectable activity from ex-vivo test

Author

Russomando, A., primary, Schiariti, M., additional, Bocci, V., additional, Colandrea, M., additional, Collamati, F., additional, Cremonesi, M., additional, Ferrari, M.E., additional, Ferroli, P., additional, Ghielmetti, F., additional, Ghisini, R., additional, Grana, C.M., additional, Mancini Terracciano, C., additional, Marafini, M., additional, Mirabelli, R., additional, Morganti, S., additional, Papi, S., additional, Patanè, M., additional, Pedroli, G., additional, Pollo, B., additional, Solfaroli Camillocci, E., additional, Traini, G., additional, and Faccini, R., additional

Published
2019
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30. First ex vivo validation of a radioguided surgery technique withβ-radiation.

Author

Solfaroli Camillocci, E., primary, Schiariti, M., additional, Bocci, V., additional, Carollo, A., additional, Chiodi, G., additional, Colandrea, M., additional, Collamati, F., additional, Cremonesi, M., additional, Donnarumma, R., additional, Ferrari, M.E., additional, Ferroli, P., additional, Ghielmetti, F., additional, Grana, C.M., additional, Mancini Terracciano, C., additional, Marafini, M., additional, Morganti, S., additional, Patanè, M., additional, Pedroli, G., additional, Pollo, B., additional, Recchia, L., additional, Russomando, A., additional, Toppi, M., additional, Traini, G., additional, and Faccini, R., additional

Published
2016
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36. Softening the long-wavelength electromagnetic response of finite quantal systems

Author

Broglia, R, Alasia, F, Arcagni, P, Colo, G, Ghielmetti, F, Milani, C, Roman, H, Broglia R. A., Alasia F., Arcagni P., Colo G., Ghielmetti F., Milani C., Roman H. E., Broglia, R, Alasia, F, Arcagni, P, Colo, G, Ghielmetti, F, Milani, C, Roman, H, Broglia R. A., Alasia F., Arcagni P., Colo G., Ghielmetti F., Milani C., and Roman H. E.

Abstract

The long wavelength electromagnetic response of finite quantal systems depend on the spill-out of fermions from the surface of the system as well as on its deformation, as testified by the analysis of results obtained for fullerenes C60, C70, C90, C110 and C28Hn, as well as for alkali metal clusters, in particular Na8. Similar results are also found in the study of the electromagnetic response of atomic nuclei. © Springer-Verlag 1997.

Published
1997

42. E25 Fmri Signal Changes In Frontal Cortex Correlates With Years-to-disease-onset In A Group Of Young Premanifest Huntington Disease Subjects

Author

Nanetti, L., primary, Ferraro, S., additional, Bertolino, N., additional, Piacentini, S., additional, Mandelli, M., additional, Ghielmetti, F., additional, Castaldo, A., additional, Gellera, C., additional, Nigri, A., additional, Taroni, F., additional, Bruzzone, M., additional, Di Donato, S., additional, Grisoli, M., additional, and Mariotti, C., additional

Published
2014
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43. Frontal cortex BOLD signal changes in premanifest Huntington disease: A possible fMRI biomarker

Author

Ferraro, S., primary, Nanetti, L., additional, Piacentini, S., additional, Mandelli, M. L., additional, Bertolino, N., additional, Ghielmetti, F., additional, Epifani, F., additional, Nigri, A., additional, Taroni, F., additional, Bruzzone, M. G., additional, Donato, S. D., additional, Savoiardo, M., additional, Mariotti, C., additional, and Grisoli, M., additional

Published
2014
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47. Preoperative language lateralization in temporal lobe epilepsy (TLE) predicts peri-ictal, pre- and post-operative language performance: An fMRI study

Author

Rosazza, C., primary, Ghielmetti, F., additional, Minati, L., additional, Vitali, P., additional, Giovagnoli, A.R., additional, Deleo, F., additional, Didato, G., additional, Parente, A., additional, Marras, C., additional, Bruzzone, M.G., additional, D'Incerti, L., additional, Spreafico, R., additional, and Villani, F., additional

Published
2013
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48. First ex vivo validation of a radioguided surgery technique with [formula omitted]-radiation.

Author

Solfaroli Camillocci, E., Schiariti, M., Bocci, V., Carollo, A., Chiodi, G., Colandrea, M., Collamati, F., Cremonesi, M., Donnarumma, R., Ferrari, M.E., Ferroli, P., Ghielmetti, F., Grana, C.M., Mancini Terracciano, C., Marafini, M., Morganti, S., Patanè, M., Pedroli, G., Pollo, B., and Recchia, L.

Abstract

Purpose A radio-guided surgery technique with β - -emitting radio-tracers was suggested to overcome the effect of the large penetration of γ radiation. The feasibility studies in the case of brain tumors and abdominal neuro-endocrine tumors were based on simulations starting from PET images with several underlying assumptions. This paper reports, as proof-of-principle of this technique, an ex vivo test on a meningioma patient. This test allowed to validate the whole chain, from the evaluation of the SUV of the tumor, to the assumptions on the bio-distribution and the signal detection. Methods A patient affected by meningioma was administered 300 MBq of 90 Y-DOTATOC. Several samples extracted from the meningioma and the nearby Dura Mater were analyzed with a β - probe designed specifically for this radio-guided surgery technique. The observed signals were compared both with the evaluation from the histology and with the Monte Carlo simulation. Results we obtained a large signal on the bulk tumor (105 cps) and a significant signal on residuals of ∼0.2 ml (28 cps). We also show that simulations predict correctly the observed yields and this allows us to estimate that the healthy tissues would return negligible signals (≈1 cps). This test also demonstrated that the exposure of the medical staff is negligible and that among the biological wastes only urine has a significant activity. Conclusions This proof-of-principle test on a patient assessed that the technique is feasible with negligible background to medical personnel and confirmed that the expectations obtained with Monte Carlo simulations starting from diagnostic PET images are correct. [ABSTRACT FROM AUTHOR]

Published
2016
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