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3,298 results on '"Ghia P"'

1. Large-scale cosmic ray anisotropies with 19 years of data from the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Ambrosone, A., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Dourado, L. Andrade, Andringa, S., Apollonio, L., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Campuzano, F., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Čermáková, B., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Errico, B., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorosti, Q., Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farrar, G., Fauth, A. C., Fehler, T., Feldbusch, F., Fernandes, A., Fick, B., Figueira, J. M., Filip, P., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Freitas, M., Fujii, T., Fuster, A., Galea, C., García, B., Gaudu, C., Ghia, P. L., Giaccari, U., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Góra, D., Gorgi, A., Gottowik, M., Guarino, F., Guedes, G. P., Guido, E., Gülzow, L., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Jilek, V., Jurysek, J., Kampert, K. -H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Köhler, J., Krieger, F., Kubatova, M., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lundquist, J. P., Payeras, A. Machado, Mandat, D., Manning, B. C., Mantsch, P., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mathes, H. -J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pelgrims, V., Pereira, L. A. S., Martins, E. E. Pereira, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reuzki, A., Ridky, J., Riehn, F., Risse, M., Rizi, V., Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Sampathkumar, P., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Sedoski, A., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Simkova, K., Simon, F., Šmída, R., Sommers, P., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Strähnz, S., Straub, M., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Tueros, M., Unger, M., Uzeiroska, R., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vašíčková, V., Vásquez-Ramírez, A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Weitz, M., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Results are presented for the measurement of large-scale anisotropies in the arrival directions of ultra-high-energy cosmic rays detected at the Pierre Auger Observatory during 19 years of operation, prior to AugerPrime, the upgrade of the Observatory. The 3D dipole amplitude and direction are reconstructed above $4\,$EeV in four energy bins. Besides the established dipolar anisotropy in right ascension above $8\,$EeV, the Fourier amplitude of the $8$ to $16\,$EeV energy bin is now also above the $5\sigma$ discovery level. No time variation of the dipole moment above $8\,$EeV is found, setting an upper limit to the rate of change of such variations of $0.3\%$ per year at the $95\%$ confidence level. Additionally, the results for the angular power spectrum are shown, demonstrating no other statistically significant multipoles. The results for the equatorial dipole component down to $0.03\,$EeV are presented, using for the first time a data set obtained with a trigger that has been optimized for lower energies. Finally, model predictions are discussed and compared with observations, based on two source emission scenarios obtained in the combined fit of spectrum and composition above $0.6\,$EeV., Comment: Minor modifications, accepted for publication in Astrophysical Journal
Published: 2024

2. The flux of ultra-high-energy cosmic rays along the supergalactic plane measured at the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Dourado, L. Andrade, Andringa, S., Apollonio, L., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Campuzano, F., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Čermáková, B., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Errico, B., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorosti, Q., Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farrar, G., Fauth, A. C., Fehler, T., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filip, P., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., García, B., Gaudu, C., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Góra, D., Gorgi, A., Gottowik, M., Guarino, F., Guedes, G. P., Guido, E., Gülzow, L., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Jilek, V., Johnsen, J. A., Jurysek, J., Kampert, K. -H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Köhler, J., Krieger, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Mantsch, P., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mathes, H. -J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pelgrims, V., Pereira, L. A. S., Martins, E. E. Pereira, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reininghaus, M., Reuzki, A., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Sedoski, A., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Simkova, K., Simon, F., Smau, R., Šmída, R., Sommers, P., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Strähnz, S., Straub, M., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Tueros, M., Unger, M., Uzeiroska, R., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vašíčková, V., Vásquez-Ramírez, A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Ultra-high-energy cosmic rays are known to be mainly of extragalactic origin, and their propagation is limited by energy losses, so their arrival directions are expected to correlate with the large-scale structure of the local Universe. In this work, we investigate the possible presence of intermediate-scale excesses in the flux of the most energetic cosmic rays from the direction of the supergalactic plane region using events with energies above 20 EeV recorded with the surface detector array of the Pierre Auger Observatory up to 31 December 2022, with a total exposure of 135,000 km^2 sr yr. The strongest indication for an excess that we find, with a post-trial significance of 3.1{\sigma}, is in the Centaurus region, as in our previous reports, and it extends down to lower energies than previously studied. We do not find any strong hints of excesses from any other region of the supergalactic plane at the same angular scale. In particular, our results do not confirm the reports by the Telescope Array collaboration of excesses from two regions in the Northern Hemisphere at the edge of the field of view of the Pierre Auger Observatory. With a comparable exposure, our results in those regions are in good agreement with the expectations from an isotropic distribution., Comment: submitted to ApJ
Published: 2024

3. Search for photons above 10$^{18}$ eV by simultaneously measuring the atmospheric depth and the muon content of air showers at the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Dourado, L. Andrade, Andringa, S., Apollonio, L., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Campuzano, F., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Čermáková, B., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Errico, B., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., do, J. A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorosti, Q., Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farrar, G., Fauth, A. C., Fehler, T., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filip, P., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., García, B., Gaudu, C., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Góra, D., Gorgi, A., Gottowik, M., Guarino, F., Guedes, G. P., Guido, E., Gülzow, L., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Jilek, V., Johnsen, J. A., Jurysek, J., Kampert, K. -H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Köhler, J., Krieger, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Mantsch, P., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mathes, H. -J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pelgrims, V., Pereira, L. A. S., Martins, E. E. Pereira, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reininghaus, M., Reuzki, A., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Sedoski, A., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Simkova, K., Simon, F., Smau, R., Šmída, R., Sommers, P., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Strähnz, S., Straub, M., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Tueros, M., Unger, M., Uzeiroska, R., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vašíčková, V., Vásquez-Ramírez, A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The Pierre Auger Observatory is the most sensitive instrument to detect photons with energies above $10^{17}$ eV. It measures extensive air showers generated by ultra high energy cosmic rays using a hybrid technique that exploits the combination of a fluorescence detector with a ground array of particle detectors. The signatures of a photon-induced air shower are a larger atmospheric depth of the shower maximum ($X_{max}$) and a steeper lateral distribution function, along with a lower number of muons with respect to the bulk of hadron-induced cascades. In this work, a new analysis technique in the energy interval between 1 and 30 EeV (1 EeV = $10^{18}$ eV) has been developed by combining the fluorescence detector-based measurement of $X_{max}$ with the specific features of the surface detector signal through a parameter related to the air shower muon content, derived from the universality of the air shower development. No evidence of a statistically significant signal due to photon primaries was found using data collected in about 12 years of operation. Thus, upper bounds to the integral photon flux have been set using a detailed calculation of the detector exposure, in combination with a data-driven background estimation. The derived 95% confidence level upper limits are 0.0403, 0.01113, 0.0035, 0.0023, and 0.0021 km$^{-2}$ sr$^{-1}$ yr$^{-1}$ above 1, 2, 3, 5, and 10 EeV, respectively, leading to the most stringent upper limits on the photon flux in the EeV range. Compared with past results, the upper limits were improved by about 40% for the lowest energy threshold and by a factor 3 above 3 EeV, where no candidates were found and the expected background is negligible. The presented limits can be used to probe the assumptions on chemical composition of ultra-high energy cosmic rays and allow for the constraint of the mass and lifetime phase space of super-heavy dark matter particles., Comment: 19 pages, 22 figures
Published: 2024

4. Measurement of the Depth of Maximum of Air-Shower Profiles with energies between $\mathbf{10^{18.5}}$ and $\mathbf{10^{20}}$ eV using the Surface Detector of the Pierre Auger Observatory and Deep Learning

Author: The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Dourado, L. Andrade, Andringa, S., Apollonio, L., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Campuzano, F., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Čermáková, B., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Errico, B., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., do, J. A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorosti, Q., Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farrar, G., Fauth, A. C., Fehler, T., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filip, P., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., García, B., Gaudu, C., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Góra, D., Gorgi, A., Gottowik, M., Guarino, F., Guedes, G. P., Guido, E., Gülzow, L., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Jilek, V., Johnsen, J. A., Jurysek, J., Kampert, K. -H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Köhler, J., Krieger, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Mantsch, P., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mathes, H. -J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pelgrims, V., Pereira, L. A. S., Martins, E. E. Pereira, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reininghaus, M., Reuzki, A., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Sedoski, A., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Simkova, K., Simon, F., Smau, R., Šmída, R., Sommers, P., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Strähnz, S., Straub, M., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Tueros, M., Unger, M., Uzeiroska, R., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vašíčková, V., Vásquez-Ramírez, A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: We report an investigation of the mass composition of cosmic rays with energies from 3 to 100 EeV (1 EeV=$10^{18}$ eV) using the distributions of the depth of shower maximum $X_\mathrm{max}$. The analysis relies on ${\sim}50,000$ events recorded by the Surface Detector of the Pierre Auger Observatory and a deep-learning-based reconstruction algorithm. Above energies of 5 EeV, the data set offers a 10-fold increase in statistics with respect to fluorescence measurements at the Observatory. After cross-calibration using the Fluorescence Detector, this enables the first measurement of the evolution of the mean and the standard deviation of the $X_\mathrm{max}$ distributions up to 100 EeV. Our findings are threefold: (1.) The evolution of the mean logarithmic mass towards a heavier composition with increasing energy can be confirmed and is extended to 100 EeV. (2.) The evolution of the fluctuations of $X_\mathrm{max}$ towards a heavier and purer composition with increasing energy can be confirmed with high statistics. We report a rather heavy composition and small fluctuations in $X_\mathrm{max}$ at the highest energies. (3.) We find indications for a characteristic structure beyond a constant change in the mean logarithmic mass, featuring three breaks that are observed in proximity to the ankle, instep, and suppression features in the energy spectrum., Comment: submitted to Phys. Rev. D, 28 pages, 18 figures, 5 tables
Published: 2024

5. Inference of the Mass Composition of Cosmic Rays with energies from $\mathbf{10^{18.5}}$ to $\mathbf{10^{20}}$ eV using the Pierre Auger Observatory and Deep Learning

Author: The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Dourado, L. Andrade, Andringa, S., Apollonio, L., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Campuzano, F., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Čermáková, B., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Errico, B., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., do, J. A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorosti, Q., Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farrar, G., Fauth, A. C., Fehler, T., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filip, P., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., García, B., Gaudu, C., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Góra, D., Gorgi, A., Gottowik, M., Guarino, F., Guedes, G. P., Guido, E., Gülzow, L., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Jilek, V., Johnsen, J. A., Jurysek, J., Kampert, K. -H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Köhler, J., Krieger, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Mantsch, P., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mathes, H. -J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pelgrims, V., Pereira, L. A. S., Martins, E. E. Pereira, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reininghaus, M., Reuzki, A., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Sedoski, A., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Simkova, K., Simon, F., Smau, R., Šmída, R., Sommers, P., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Strähnz, S., Straub, M., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Tueros, M., Unger, M., Uzeiroska, R., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vašíčková, V., Vásquez-Ramírez, A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: We present measurements of the atmospheric depth of the shower maximum $X_\mathrm{max}$, inferred for the first time on an event-by-event level using the Surface Detector of the Pierre Auger Observatory. Using deep learning, we were able to extend measurements of the $X_\mathrm{max}$ distributions up to energies of 100 EeV ($10^{20}$ eV), not yet revealed by current measurements, providing new insights into the mass composition of cosmic rays at extreme energies. Gaining a 10-fold increase in statistics compared to the Fluorescence Detector data, we find evidence that the rate of change of the average $X_\mathrm{max}$ with the logarithm of energy features three breaks at $6.5\pm0.6~(\mathrm{stat})\pm1~(\mathrm{sys})$ EeV, $11\pm 2~(\mathrm{stat})\pm1~(\mathrm{sys})$ EeV, and $31\pm5~(\mathrm{stat})\pm3~(\mathrm{sys})$ EeV, in the vicinity to the three prominent features (ankle, instep, suppression) of the cosmic-ray flux. The energy evolution of the mean and standard deviation of the measured $X_\mathrm{max}$ distributions indicates that the mass composition becomes increasingly heavier and purer, thus being incompatible with a large fraction of light nuclei between 50 EeV and 100 EeV., Comment: submitted to Phys. Rev. Lett., 10 pages, 3 figures, 1 table
Published: 2024

6. Outcomes in high-risk subgroups after fixed-duration ibrutinib + venetoclax for chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL): Up to 5.5 years of follow-up in the phase 2 CAPTIVATE study.

Author: Wierda, William G, Jacobs, Ryan, Barr, Paul M, Allan, John N, Siddiqi, Tanya, Tedeschi, Alessandra, Kipps, Thomas J, O'Brien, Susan Mary, Badoux, Xavier C, Visentin, Andrea, Lasica, Masa, Carney, Dennis, Elinder Camburn, Anna, De La Serna Torroba, Javier, Szafer-Glusman, Edith, Zhou, Cathy, Szoke, Anita, Dean, James P, Ghia, Paolo, and Tam, Constantine S
Subjects: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Lymphoma, Biotechnology, Cancer Genomics, Hematology, Precision Medicine, Genetics, Cancer, Clinical Trials and Supportive Activities, Lymphatic Research, Minority Health, Rare Diseases, Human Genome, 6.1 Pharmaceuticals, Clinical Sciences, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract: 7009 Background: The phase 2 CAPTIVATE study evaluated first-line ibrutinib (Ibr) + venetoclax (Ven) for CLL/SLL in 2 cohorts: minimal residual disease (MRD)-guided randomized discontinuation (MRD cohort) and Fixed Duration (FD cohort). Ibr±Ven retreatment was allowed in patients (pts) who had progressive disease (PD). Here, we report outcomes for pts with high-risk genomic features from the FD cohort and retreatment outcomes in pts from the FD cohort and MRD cohort placebo arm. Methods: Pts aged ≤70 y with previously untreated CLL/SLL without restriction on genomic risk factors received 3 cycles of Ibr, then 12 cycles of Ibr+Ven (Ibr, 420 mg/d orally; Ven, 5-wk ramp up to 400 mg/d orally). On-study retreatment included single-agent Ibr (FD cohort or MRD cohort placebo arm); pts with PD >2 y after end of treatment (EOT) could be retreated with FD Ibr+Ven (FD cohort). Results: In the FD cohort (n=159) with a median follow-up of 61.2 mo (range, 0.8–66.3), 5-y PFS and OS rates (95% CI) were 67% (59–74) and 96% (91–98), respectively. 5-y PFS rates were higher in pts with undetectable MRD at 3 mo after EOT in peripheral blood (83%) or bone marrow (84%) vs those without (48% and 50%, respectively). 5-y PFS rates (95% CI) in pts with genomic risk factors were: del(17p)/mutated TP53 41% (21–59), complex karyotype 57% (37–72), del(11q) 64% (30–85), and unmutated IGHV 68% (50–80) (Table). In total, 18 second malignancies occurred in 13 pts (10 events in 8 pts during FD Ibr+Ven, 6 events in 4 pts after EOT and before retreatment, and 2 events in 2 pts during retreatment). Of 202 pts who completed Ibr+Ven (FD cohort, n=159; MRD cohort placebo arm, n=43), 63 have had PD to date; PD occurred >2 y after EOT in 43/63 pts (68%). 32/63 (51%) pts initiated retreatment with Ibr (n=25) or Ibr+Ven (n=7). With a median time on Ibr retreatment of 21.9 mo (range, 0.03–50.4), ORR was 86% in 22 evaluable pts (best response: 1 CR; 1 nodular PR; 17 PR; 2 SD; 1 PD [Richter transformation]). With a median time on Ibr+Ven retreatment of 13.8 mo (range, 3.7–15.1), ORR was 71% in 7 evaluable pts (best response: 1 CR; 4 PR; 1 PR with lymphocytosis; 1 SD). Conclusions: With up to 5.5 y of follow-up, FD Ibr+Ven continues to provide clinically meaningful PFS in pts with high-risk genomic features, as well as in the overall population. Ibr-based retreatment provides promising responses in pts needing subsequent therapy after the all-oral FD regimen of Ibr+Ven. Clinical trial information: NCT02910583 . [Table: see text]
Published: 2024

7. Aberrant spliceosome activity via elevated intron retention and upregulation and phosphorylation of SF3B1 in chronic lymphocytic leukemia

Author: Kashyap, Manoj Kumar, Karathia, Hiren, Kumar, Deepak, Alvarez, Roberto Vera, Forero-Forero, Jose Vicente, Moreno, Eider, Lujan, Juliana Velez, Amaya-Chanaga, Carlos Ivan, Vidal, Newton Medeiros, Yu, Zhe, Ghia, Emanuela M, Lengerke-Diaz, Paula A, Achinko, Daniel, Choi, Michael Y, Rassenti, Laura Z, Mariño-Ramírez, Leonardo, Mount, Stephen M, Hannenhalli, Sridhar, Kipps, Thomas J, and Castro, Januario E
Subjects: Biological Sciences, Bioinformatics and Computational Biology, Hematology, Lymphoma, Genetics, Rare Diseases, Cancer, Lymphatic Research, Aetiology, 2.1 Biological and endogenous factors, CLL, E7107, MT: RNA/DNA Editing, RNA splicing, RNA-seq, SF3B1, alternative RNA splicing, intron retention, intron usage, macrolide, pladienolide-B, spliceosome, Biochemistry and Cell Biology, Clinical Sciences, Biochemistry and cell biology
Abstract: Splicing factor 3b subunit 1 (SF3B1) is the largest subunit and core component of the spliceosome. Inhibition of SF3B1 was associated with an increase in broad intron retention (IR) on most transcripts, suggesting that IR can be used as a marker of spliceosome inhibition in chronic lymphocytic leukemia (CLL) cells. Furthermore, we separately analyzed exonic and intronic mapped reads on annotated RNA-sequencing transcripts obtained from B cells (n = 98 CLL patients) and healthy volunteers (n = 9). We measured intron/exon ratio to use that as a surrogate for alternative RNA splicing (ARS) and found that 66% of CLL-B cell transcripts had significant IR elevation compared with normal B cells (NBCs) and that correlated with mRNA downregulation and low expression levels. Transcripts with the highest IR levels belonged to biological pathways associated with gene expression and RNA splicing. A >2-fold increase of active pSF3B1 was observed in CLL-B cells compared with NBCs. Additionally, when the CLL-B cells were treated with macrolides (pladienolide-B), a significant decrease in pSF3B1, but not total SF3B1 protein, was observed. These findings suggest that IR/ARS is increased in CLL, which is associated with SF3B1 phosphorylation and susceptibility to SF3B1 inhibitors. These data provide additional support to the relevance of ARS in carcinogenesis and evidence of pSF3B1 participation in this process.
Published: 2024

8. The non-canonical BAF chromatin remodeling complex is a novel target of spliceosome dysregulation in SF3B1-mutated chronic lymphocytic leukemia

Author: Hägerstrand, Daniel, Oder, Blaž, Cortese, Diego, Qu, Ying, Binzer-Panchal, Amrei, Österholm, Cecilia, Del Peso Santos, Teresa, Rabbani, Leily, Asl, Hassan Foroughi, Skaftason, Aron, Ljungström, Viktor, Lundholm, August, Koutroumani, Maria, Haider, Zahra, Jylhä, Cecilia, Mollstedt, John, Mansouri, Larry, Plevova, Karla, Agathangelidis, Andreas, Scarfò, Lydia, Armand, Marine, Muggen, Alice F., Kay, Neil E., Shanafelt, Tait, Rossi, Davide, Orre, Lukas M., Pospisilova, Sarka, Barylyuk, Konstantin, Davi, Frederic, Vesterlund, Mattias, Langerak, Anton W., Lehtiö, Janne, Ghia, Paolo, Stamatopoulos, Kostas, Sutton, Lesley-Ann, and Rosenquist, Richard
Published: 2024
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9. Navigating the changing landscape of BTK-targeted therapies for B cell lymphomas and chronic lymphocytic leukaemia

Author: Stanchina, Michele D., Montoya, Skye, Danilov, Alexey V., Castillo, Jorge J., Alencar, Alvaro J., Chavez, Julio C., Cheah, Chan Y., Chiattone, Carlos, Wang, Yucai, Thompson, Meghan, Ghia, Paolo, Taylor, Justin, and Alderuccio, Juan Pablo
Published: 2024
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10. Spinal laser interstitial thermal therapy and radiotherapy for thoracic metastatic epidural spinal cord compression

Author: Tom, Martin C., Komatineni, Suraj, Wang, Chenyang, de Almeida, Romulo A. Andrade, Ghia, Amol J., Beckham, Thomas H., Perni, Subha, McAleer, Mary F., Swanson, Todd, Yeboa, Debra N., De, Brian S., Rooney, Michael K., Bishop, Andrew J., Reddy, Jay P., Yang, Yumeng, Ludmir, Ethan B., Zhang, Shizhen, Amini, Behrang, Alvarez-Breckenridge, Christopher, North, Robert Y., Rhines, Laurence D., Li, Jing, and Tatsui, Claudio E.
Published: 2024
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11. Cranial and spinal nerve enhancement in SURF1-associated Leigh syndrome

Author: Dupré, Mhairi, Warne, Richard, Shipman, Peter, Kava, Maina, Ghia, Twinkle, Loughman, Lily, and Lakshmanan, Rahul
Published: 2024
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12. Testing Hadronic-Model Predictions of Depth of Maximum of Air-Shower Profiles and Ground-Particle Signals using Hybrid Data of the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Apollonio, L., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Campuzano, F., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., de Errico, B. P. de Souza, De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorosti, Q., Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gaudu, C., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Gülzow, L., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Jilek, V., Johnsen, J. A., Jurysek, J., Kampert, K. -H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Köhler, J., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Mantsch, P., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mathes, H. -J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pereira, L. A. S., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Sedoski, A., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Simkova, K., Simon, F., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Strähnz, S., Straub, M., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We test the predictions of hadronic interaction models regarding the depth of maximum of air-shower profiles, $X_{max}$, and ground-particle signals in water-Cherenkov detectors at 1000 m from the shower core, $S(1000)$, using the data from the fluorescence and surface detectors of the Pierre Auger Observatory. The test consists in fitting the measured two-dimensional ($S(1000)$, $X_{max}$) distributions using templates for simulated air showers produced with hadronic interaction models EPOS-LHC, QGSJet II-04, Sibyll 2.3d and leaving the scales of predicted $X_{max}$ and the signals from hadronic component at ground as free fit parameters. The method relies on the assumption that the mass composition remains the same at all zenith angles, while the longitudinal shower development and attenuation of ground signal depend on the mass composition in a correlated way. The analysis was applied to 2239 events detected by both the fluorescence and surface detectors of the Pierre Auger Observatory with energies between $10^{18.5}$ to $10^{19.0}$ eV and zenith angles below $60^\circ$. We found, that within the assumptions of the method, the best description of the data is achieved if the predictions of the hadronic interaction models are shifted to deeper $X_{max}$ values and larger hadronic signals at all zenith angles. Given the magnitude of the shifts and the data sample size, the statistical significance of the improvement of data description using the modifications considered in the paper is larger than $5\sigma$ even for any linear combination of experimental systematic uncertainties., Comment: Published version
Published: 2024
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13. ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—2024 update

Author: Malcikova, Jitka, Pavlova, Sarka, Baliakas, Panagiotis, Chatzikonstantinou, Thomas, Tausch, Eugen, Catherwood, Mark, Rossi, Davide, Soussi, Thierry, Tichy, Boris, Kater, Arnon P., Niemann, Carsten U., Davi, Frederic, Gaidano, Gianluca, Stilgenbauer, Stephan, Rosenquist, Richard, Stamatopoulos, Kostas, Ghia, Paolo, and Pospisilova, Sarka
Published: 2024
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14. IκBε deficiency accelerates disease development in chronic lymphocytic leukemia

Author: Bordini, Jessica, Lenzi, Chiara, Frenquelli, Michela, Morabito, Alessia, Pseftogas, Athanasios, Belloni, Daniela, Mansouri, Larry, Tsiolas, George, Perotta, Eleonora, Ranghetti, Pamela, Gandini, Francesca, Genova, Francesca, Hägerstrand, Daniel, Gavriilidis, Georgios, Keisaris, Sofoklis, Pechlivanis, Nikolaos, Davi, Frederic, Kay, Neil E., Langerak, Anton W., Pospisilova, Sarka, Scarfò, Lydia, Makris, Antonios, Psomopoulos, Fotis E., Stamatopoulos, Kostas, Rosenquist, Richard, Campanella, Alessandro, and Ghia, Paolo
Published: 2024
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15. Constraints on metastable superheavy dark matter coupled to sterile neutrinos with the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Apollonio, L., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Campuzano, F., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., de Errico, B. P. de Souza, De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorosti, Q., Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gaudu, C., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Gülzow, L., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Jilek, V., Johnsen, J. A., Jurysek, J., Kampert, K. -H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Köhler, J., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Mantsch, P., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mathes, H. -J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pereira, L. A. S., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Sedoski, A., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Simkova, K., Simon, F., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Strähnz, S., Straub, M., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.
Subjects: High Energy Physics - Phenomenology, Astrophysics - High Energy Astrophysical Phenomena
Abstract: Dark matter particles could be superheavy, provided their lifetime is much longer than the age of the universe. Using the sensitivity of the Pierre Auger Observatory to ultra-high energy neutrinos and photons, we constrain a specific extension of the Standard Model of particle physics that meets the lifetime requirement for a superheavy particle by coupling it to a sector of ultra-light sterile neutrinos. Our results show that, for a typical dark coupling constant of 0.1, the mixing angle $\theta_m$ between active and sterile neutrinos must satisfy, roughly, $\theta_m \lesssim 1.5\times 10^{-6}(M_X/10^9~\mathrm{GeV})^{-2}$ for a mass $M_X$ of the dark-matter particle between $10^8$ and $10^{11}~$GeV., Comment: Version accepted for publication in PRD Letters, including Supplemental Material
Published: 2023
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16. Radio Measurements of the Depth of Air-Shower Maximum at the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Anukriti, Apollonio, L., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., de Errico, B. P. de Souza, De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorosti, Q., Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gaudu, C., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Gülzow, L., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Jilek, V., Johnsen, J. A., Jurysek, J., Kampert, K. -H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Köhler, J., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mathes, H. -J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pereira, L. A. S., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Simkova, K., Simon, F., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Strähnz, S., Straub, M., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Auger Engineering Radio Array (AERA), part of the Pierre Auger Observatory, is currently the largest array of radio antenna stations deployed for the detection of cosmic rays, spanning an area of $17$ km$^2$ with 153 radio stations. It detects the radio emission of extensive air showers produced by cosmic rays in the $30-80$ MHz band. Here, we report the AERA measurements of the depth of the shower maximum ($X_\text{max}$), a probe for mass composition, at cosmic-ray energies between $10^{17.5}$ to $10^{18.8}$ eV, which show agreement with earlier measurements with the fluorescence technique at the Pierre Auger Observatory. We show advancements in the method for radio $X_\text{max}$ reconstruction by comparison to dedicated sets of CORSIKA/CoREAS air-shower simulations, including steps of reconstruction-bias identification and correction, which is of particular importance for irregular or sparse radio arrays. Using the largest set of radio air-shower measurements to date, we show the radio $X_\text{max}$ resolution as a function of energy, reaching a resolution better than $15$ g cm$^{-2}$ at the highest energies, demonstrating that radio $X_\text{max}$ measurements are competitive with the established high-precision fluorescence technique. In addition, we developed a procedure for performing an extensive data-driven study of systematic uncertainties, including the effects of acceptance bias, reconstruction bias, and the investigation of possible residual biases. These results have been cross-checked with air showers measured independently with both the radio and fluorescence techniques, a setup unique to the Pierre Auger Observatory., Comment: Submitted to Phys. Rev. D
Published: 2023

17. Demonstrating Agreement between Radio and Fluorescence Measurements of the Depth of Maximum of Extensive Air Showers at the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Anukriti, Apollonio, L., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., de Errico, B. P. de Souza, De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorosti, Q., Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gaudu, C., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Gülzow, L., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Jilek, V., Johnsen, J. A., Jurysek, J., Kampert, K. -H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Köhler, J., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mathes, H. -J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pereira, L. A. S., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Simkova, K., Simon, F., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Strähnz, S., Straub, M., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: We show, for the first time, radio measurements of the depth of shower maximum ($X_\text{max}$) of air showers induced by cosmic rays that are compared to measurements of the established fluorescence method at the same location. Using measurements at the Pierre Auger Observatory we show full compatibility between our radio and the previously published fluorescence data set, and between a subset of air showers observed simultaneously with both radio and fluorescence techniques, a measurement setup unique to the Pierre Auger Observatory. Furthermore, we show radio $X_\text{max}$ resolution as a function of energy and demonstrate the ability to make competitive high-resolution $X_\text{max}$ measurements with even a sparse radio array. With this, we show that the radio technique is capable of cosmic-ray mass composition studies, both at Auger and at other experiments., Comment: Submitted to Phys. Rev. Lett
Published: 2023

18. Ground observations of a space laser for the assessment of its in-orbit performance

Author: The Pierre Auger Collaboration, Lux, O., Krisch, I., Reitebuch, O., Huber, D., Wernham, D., Parrinello, T., Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Anukriti, Apollonio, L., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Bwembya, A., Büsken, M., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., de Errico, B. P. de Souza, De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorosti, Q., Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gaudu, C., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Gongora, J. P., González, J. M., González, N., Goos, I., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Berisso, M. Gómez, Vitale, P. F. Gómez, Góra, D., Gülzow, L., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Horvath, P., Hrabovský, M., Huege, T., Hörandel, J. R., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Kunka, N., Köhler, J., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Martins, M. A., Bravo, O. Martínez, Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pelayo, R., Pereira, L. A. S., Martins, E. E. Pereira, Armand, J. Perez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Bertolli, C. Pérez, Pękala, J., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Schäfer, C. M., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Simkova, K., Simon, F., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Strähnz, S., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Sánchez, F., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vlastimil, J., Vorobiov, S., Vásquez-Ramírez, A., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Atmospheric and Oceanic Physics, Physics - Optics
Abstract: The wind mission Aeolus of the European Space Agency was a groundbreaking achievement for Earth observation. Between 2018 and 2023, the space-borne lidar instrument ALADIN onboard the Aeolus satellite measured atmospheric wind profiles with global coverage which contributed to improving the accuracy of numerical weather prediction. The precision of the wind observations, however, declined over the course of the mission due to a progressive loss of the atmospheric backscatter signal. The analysis of the root cause was supported by the Pierre Auger Observatory in Argentina whose fluorescence detector registered the ultraviolet laser pulses emitted from the instrument in space, thereby offering an estimation of the laser energy at the exit of the instrument for several days in 2019, 2020 and 2021. The reconstruction of the laser beam not only allowed for an independent assessment of the Aeolus performance, but also helped to improve the accuracy in the determination of the laser beam's ground track on single pulse level. The results presented in this paper set a precedent for the monitoring of space lasers by ground-based telescopes and open new possibilities for the calibration of cosmic-ray observatories., Comment: 10 pages, 10 figures
Published: 2023

19. The Pierre Auger Observatory Open Data

Author: The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Dourado, L. Andrade, Andringa, S., Apollonio, L., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Campuzano, F., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Čermáková, B., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Errico, B., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorosti, Q., Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farrar, G., Fauth, A. C., Fehler, T., Feldbusch, F., Fernandes, A., Fick, B., Figueira, J. M., Filip, P., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Freitas, M., Fujii, T., Fuster, A., Galea, C., García, B., Gaudu, C., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Góra, D., Gorgi, A., Gottowik, M., Guarino, F., Guedes, G. P., Guido, E., Gülzow, L., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Jilek, V., Jurysek, J., Kampert, K. -H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Köhler, J., Krieger, F., Kubatova, M., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lundquist, J. P., Payeras, A. Machado, Mandat, D., Manning, B. C., Mantsch, P., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mathes, H. -J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pelgrims, V., Pereira, L. A. S., Martins, E. E. Pereira, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reuzki, A., Ridky, J., Riehn, F., Risse, M., Rizi, V., Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Sampathkumar, P., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Sedoski, A., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Simkova, K., Simon, F., Smau, R., Šmída, R., Sommers, P., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Strähnz, S., Straub, M., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Tueros, M., Unger, M., Uzeiroska, R., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vašíčková, V., Vásquez-Ramírez, A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Weitz, M., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Pierre Auger Collaboration has embraced the concept of open access to their research data since its foundation, with the aim of giving access to the widest possible community. A gradual process of release began as early as 2007 when 1% of the cosmic-ray data was made public, along with 100% of the space-weather information. In February 2021, a portal was released containing 10% of cosmic-ray data collected from 2004 to 2018, during Phase I of the Observatory. The Portal included detailed documentation about the detection and reconstruction procedures, analysis codes that can be easily used and modified and, additionally, visualization tools. Since then the Portal has been updated and extended. In 2023, a catalog of the 100 highest-energy cosmic-ray events examined in depth has been included. A specific section dedicated to educational use has been developed with the expectation that these data will be explored by a wide and diverse community including professional and citizen-scientists, and used for educational and outreach initiatives. This paper describes the context, the spirit and the technical implementation of the release of data by the largest cosmic-ray detector ever built, and anticipates its future developments., Comment: 18 pages, 8 figures
Published: 2023

20. AugerPrime Surface Detector Electronics

Author: The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Anukriti, Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Barbato, F., Mocellin, A. Bartz, Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Bwembya, A., Büsken, M., Caballero-Mora, K. S., Cabana-Freire, S., Caccianiga, L., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Cermenati, A., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., de Errico, B. P. de Souza, De Vito, E., Del Popolo, A., Deligny, O., Denner, N., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gaudu, C., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Gongora, J. P., González, J. M., González, N., Goos, I., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Berisso, M. Gómez, Vitale, P. F. Gómez, Góra, D., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Horvath, P., Hrabovský, M., Huege, T., Hörandel, J. R., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y., Letessier-Selvon, A., Lhenry-Yvon, I., Lopes, L., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Martins, M. A., Bravo, O. Martínez, Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mulrey, K., Mussa, R., Namasaka, W. M., Negi, S., Nellen, L., Nguyen, K., Nicora, G., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Panja, S., Parente, G., Paulsen, T., Pawlowsky, J., Pech, M., Pelayo, R., Pereira, L. A. S., Martins, E. E. Pereira, Armand, J. Perez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Bertolli, C. Pérez, Pękala, J., Querchfeld, S., Rautenberg, J., Ravignani, D., Akim, J. V. Reginatto, Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Schäfer, C. M., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Simon, F., Smau, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Strähnz, S., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Sánchez, F., Tairli, F., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vlastimil, J., Vorobiov, S., Vásquez-Ramírez, A., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., and Šmída, R.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: Operating since 2004, the Pierre Auger Observatory has led to major advances in our understanding of the ultra-high-energy cosmic rays. The latest findings have revealed new insights that led to the upgrade of the Observatory, with the primary goal of obtaining information on the primary mass of the most energetic cosmic rays on a shower-by-shower basis. In the framework of the upgrade, called AugerPrime, the 1660 water-Cherenkov detectors of the surface array are equipped with plastic scintillators and radio antennas, allowing us to enhance the composition sensitivity. To accommodate new detectors and to increase experimental capabilities, the electronics is also upgraded. This includes better timing with up-to-date GPS receivers, higher sampling frequency, increased dynamic range, and more powerful local processing of the data. In this paper, the design characteristics of the new electronics and the enhanced dynamic range will be described. The manufacturing and test processes will be outlined and the test results will be discussed. The calibration of the SD detector and various performance parameters obtained from the analysis of the first commissioning data will also be presented.
Published: 2023

21. Correction: a phase 1b study of zilovertamab in combination with paclitaxel for locally advanced/unresectable or metastatic HER2-negative breast cancer

Author: Shatsky, Rebecca A, Batra-Sharma, Hemali, Helsten, Teresa, Schwab, Richard B, Pittman, Emily I, Pu, Minya, Weihe, Elizabeth, Ghia, Emanuela M, Rassenti, Laura Z, Molinolo, Alfredo, Cabrera, Betty, Breitmeyer, James B, Widhopf II, George F, Messer, Karen, Jamieson, Catriona, Kipps, Thomas J, and Parker, Barbara A
Subjects: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Oncology and carcinogenesis
Published: 2024

22. A phase 1b study of zilovertamab in combination with paclitaxel for locally advanced/unresectable or metastatic HER2-negative breast cancer

Author: Shatsky, Rebecca A, Batra-Sharma, Hemali, Helsten, Teresa, Schwab, Richard B, Pittman, Emily I, Pu, Minya, Weihe, Elizabeth, Ghia, Emanuela M, Rassenti, Laura Z, Molinolo, Alfredo, Cabrera, Betty, Breitmeyer, James B, Widhopf, George F, Messer, Karen, Jamieson, Catriona, Kipps, Thomas J, and Parker, Barbara A
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Immunology, Clinical Trials and Supportive Activities, Cancer, Breast Cancer, Clinical Research, Patient Safety, 6.2 Cellular and gene therapies, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Humans, Female, Breast Neoplasms, Paclitaxel, Receptor, ErbB-2, Antibodies, Monoclonal, Humanized, Antineoplastic Combined Chemotherapy Protocols, ROR1, Zilovertamab, Metastatic breast cancer, Receptor, erbB-2, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract: BackgroundZilovertamab is a humanized monoclonal antibody targeting ROR1, an onco-embryonic antigen expressed by malignant cells of a variety of solid tumors, including breast cancer. A prior phase 1 study showed that zilovertamab was well tolerated and effective in inhibiting ROR1-signaling, which leads to activation of ERK1/2, NF-κB, and NRF2 target genes. This phase 1b study evaluated the safety and tolerability of zilovertamab with paclitaxel in patients with advanced breast cancer.Patients and methodsEligible patients had locally advanced, unresectable, or metastatic HER2- breast cancer with Eastern Cooperative Group performance status of 0-2 and without prior taxane therapy in the advanced setting. Study treatment included 600 mg of zilovertamab administered intravenously (IV) on Days 1 and 15 of Cycle 1 and then Day 1 of each 28-day cycle along with paclitaxel weekly at 80 mg/m2 IV.ResultsStudy patients had received a median of 4 prior therapies (endocrine therapy + chemotherapy) for locally advanced, unresectable, or metastatic disease. No patient discontinued therapy due to toxicity ascribed to zilovertamab. Adverse events were consistent with the known safety profile of paclitaxel. Of 16 patients, 6 (38%) had a partial response, and 6/16 (38%) patients had stable disease as best tumor response.ConclusionThe combination of zilovertamab and paclitaxel was safe and well tolerated in heavily pre-treated advanced breast cancer patients. Further evaluation of ROR1 targeting in breast cancer patients with zilovertamab is warranted.Trial registrationNCT02776917. Registered on ClinicalTrials.gov on 05/17/2016.
Published: 2024

23. The DLEU2/miR-15a/miR-16-1 cluster shapes the immune microenvironment of chronic lymphocytic leukemia

Author: Ronghua Zhang, Priyanka Khare, Priyanka Banerjee, Cristina Ivan, Sarah Schneider, Federica Barbaglio, Karen Clise-Dwyer, Vanessa Behrana Jensen, Erika Thompson, Marisela Mendoza, Nicholas Chiorazzi, Shih-Shih Chen, Xiao-Jie Joy Yan, Nitin Jain, Paolo Ghia, Federico Caligaris-Cappio, Rima Mendonsa, Sashi Kasimsetty, Ryan Swoboda, Recep Bayraktar, William Wierda, Varsha Gandhi, George A. Calin, Michael J. Keating, and Maria Teresa Sabrina Bertilaccio
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract The development and progression of chronic lymphocytic leukemia (CLL) depend on genetic abnormalities and on the immunosuppressive microenvironment. We have explored the possibility that genetic drivers might be responsible for the immune cell dysregulation that shapes the protumor microenvironment. We performed a transcriptome analysis of coding and non-coding RNAs (ncRNAs) during leukemia progression in the Rag2−/−γc −/− MEC1-based xenotransplantation model. The DLEU2/miR-16 locus was found downmodulated in monocytes/macrophages of leukemic mice. To validate the role of this cluster in the tumor immune microenvironment, we generated a mouse model that simultaneously mimics the overexpression of hTCL1 and the germline deletion of the minimal deleted region (MDR) encoding the DLEU2/miR-15a/miR-16-1 cluster. This model provides an innovative and faster CLL system where monocyte differentiation and macrophage polarization are exacerbated, and T-cells are dysfunctional. MDR deletion inversely correlates with the levels of predicted target proteins including BCL2 and PD1/PD-L1 on murine CLL cells and immune cells. The inverse correlation of miR-15a/miR-16-1 with target proteins has been confirmed on patient-derived immune cells. Forced expression of miR-16-1 interferes with monocyte differentiation into tumor-associated macrophages, indicating that selected ncRNAs drive the protumor phenotype of non-malignant immune cells.
Published: 2024
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24. Understanding How Midwestern School District Administrators Decide How to Add, Eliminate, or Maintain School Resource Officers: A Qualitative Narrative Study

Author: Evangelia Ghia Burzynski
Abstract: National School Resource Officer Appreciation Day, established in 2022 and celebrated on February 15th, provides a focal point for exploring the role of School Resource Officers (SROs) in Midwestern school districts. Through qualitative research involving interviews with 10 administrators, this study examined how districts decide to add, eliminate, or maintain SROs. Triangulated data, including interviews and policy reviews, offered comprehensive insights into the decision-making processes and key factors involved. Findings revealed the significant influence of student safety, emotional triggers, and budget considerations on administrators' choices regarding SRO presence. Utilizing the constant comparative method, data analysis identified distinct categories, enhancing our understanding of influencing factors. This study contributes valuable insights into the changing aspects surrounding SROs in Midwestern school districts, emphasizing the importance of future research-informed decision-making. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
Published: 2024

25. Search for UHE Photons from Gravitational Wave Sources with the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Caccianiga, L., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Contreras, F., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, R. C. dos, Ebr, J., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Müller, A. L., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pereira, L. A. S., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shavar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Streich, A., Suárez-Durán, M., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, General Relativity and Quantum Cosmology
Abstract: A search for time-directional coincidences of ultra-high-energy (UHE) photons above 10 EeV with gravitational wave (GW) events from the LIGO/Virgo runs O1 to O3 is conducted with the Pierre Auger Observatory. Due to the distinctive properties of photon interactions and to the background expected from hadronic showers, a subset of the most interesting GW events is selected based on their localization quality and distance. Time periods of 1000 s around and 1 day after the GW events are analyzed. No coincidences are observed. Upper limits on the UHE photon fluence from a GW event are derived that are typically at $\sim$7 MeV cm$^{-2}$ (time period 1000~s) and $\sim$35 MeV cm$^{-2}$ (time period 1 day). Due to the proximity of the binary neutron star merger GW170817, the energy of the source transferred into UHE photons above 40 EeV is constrained to be less than 20% of its total gravitational wave energy. These are the first limits on UHE photons from GW sources., Comment: 15 pages
Published: 2023
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26. Multiband Photometry Evolution in the First Weeks of SN 2023ixf, a possible II-L Subtype Supernova

Author: G., Bianciardi, M., Ciccarelli A., G., Conzo, M., D'Angelo, S., Ghia, M., Moriconi, Z., Orbanić, N., Ruocco, I., Sharp, M., Uhlár, and F, Walter
Subjects: Astrophysics - Solar and Stellar Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract: Multiband photometric observations and their evaluation to instrumental magnitudes were performed using standard Johnson-Cousins filters (B, V, Rc) as well r and g Sloan filters, and not standard ones (R, G, B, and Clear filters). These were recorded from 9 observatories and from the MicroObservatory Robotic Telescope Network. The results describe the rapid ascent towards the maximum (2.5 magnitudes about in five days in the B filter) and the slow decrease after the maximum (0.0425 +/- 0.02 magnitudes/day in the B filter). The results highlight the strong variation of the B-V colour indices during the first 50 days (from -0.20 +/- 0.02 to +0.85 +/- 0.02) and V-R (from 0 +/- 0.01 to +0.50 +/- 0.01) after the explosion, presumably corresponding to the cooling of the stellar photosphere. At 50 days after the explosion the magnitude decrease from the maximum was observed to continue where it faded by 2.5 magnitudes (B filter), thus we propose SN 2023ixf is a Type II, subtype L, supernova (SNe).
Published: 2023

27. Relapse after First-Line Fixed Duration Ibrutinib + Venetoclax: High Response Rates to Ibrutinib Retreatment and Absence of BTK Mutations in Patients with Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) with up to 5 Years of Follow-up in the Phase 2 Captivate Study

Author: Ghia, Paolo, Wierda, William G, Barr, Paul M, Kipps, Thomas J, Siddiqi, Tanya, Allan, John N, Hunter, Zoë, Zhou, Cathy, Szoke, Anita, Dean, James P, and Tam, Constantine S
Subjects: Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Oncology and Carcinogenesis, Cancer, Clinical Research, Precision Medicine, Rare Diseases, Lymphatic Research, Hematology, Lymphoma, Orphan Drug, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Paediatrics and Reproductive Medicine, Immunology, Biochemistry and cell biology, Cardiovascular medicine and haematology, Paediatrics
Abstract: Background: CAPTIVATE (PCYC-1142) is a multicenter phase 2 study of ibrutinib + venetoclax as first-line treatment for CLL/SLL in 2 cohorts: minimal residual disease (MRD)-guided randomized-discontinuation (MRD cohort) and Fixed Duration (FD cohort). Results from the FD cohort with 4 years of follow-up (Barr, ASCO 2023) showed 4-year progression-free survival (PFS) and overall survival (OS) rates of 79% and 98%, respectively. After completing fixed-duration treatment, ibrutinib-based retreatment was allowed per protocol in patients with an indication for treatment after experiencing progressive disease (PD). Here, we report retreatment outcomes in patients from the FD cohort or the MRD cohort placebo arm, as well as updated results with an additional year of follow-up (up to 5 years) from the FD cohort. Methods: Patients aged ≤70 years with previously untreated CLL/SLL received 3 cycles of ibrutinib, then 12 cycles of combined ibrutinib + venetoclax (ibrutinib, 420 mg/day orally; venetoclax, standard 5-week ramp up to 400 mg/day orally). Response was assessed by investigators per International Workshop on CLL (iwCLL) 2008 criteria. Duration of response (DOR), PFS, and OS were estimated using Kaplan-Meier methodology. Per protocol, on-study retreatment included single-agent ibrutinib; patients with PD >2 years after treatment completion could be retreated with the FD regimen (3 cycles of ibrutinib + 12 cycles of ibrutinib + venetoclax). Results: Of 202 patients treated with fixed-duration ibrutinib + venetoclax in the FD cohort (n=159) or the MRD cohort placebo arm (n=43), 53 have had PD to date (Table 1), with PD occurring >2 years after completion of treatment in the majority of patients (33/53 [62%]). Of the 40 patients with available samples at PD, one had an acquired resistance-associated mutation in BCL2 (A113G); no other patient had clinically relevant mutations in BTK, BCL2, or PLCG2. A total of 22 patients have initiated retreatment on study with single-agent ibrutinib. With a median time on retreatment of 17 months (range, 0-45), overall response rate (ORR) in 21 evaluable patients was 86% (with best responses of complete response [CR], n=1 [5%]; partial response [PR], n=17 [81%]; PR with lymphocytosis, n=1 [5%]; stable disease, n=1 [5%]; PD [Richter transformation], n=1 [5%]). The most frequent adverse events (AEs; occurrence ≥10%) during single-agent ibrutinib retreatment were COVID-19 (n=6, all grade 1/2), diarrhea (n=5), hypertension (n=4), and pyrexia (n=3). No dose reductions or discontinuations due to AEs occurred among retreated patients. Eighteen patients have not received subsequent treatment, 7 patients have initiated other subsequent therapies, and 6 patients have started retreatment with ibrutinib + venetoclax (time on retreatment, 5-15 months). Best responses in patients retreated with ibrutinib + venetoclax are CR, n=2; PR, n=3; and SD, n=1. Response data for the patient with BCL2 (A113G) is pending. To date, with a median time on study of 56 months (range, 1-61) for patients in the FD cohort, the 54-month PFS and OS rates were 70% (95% CI, 62-77) and 97% (95% CI, 93-99), respectively. Best response rates remained unchanged from the 4-year follow-up analysis (CR, including CR with incomplete bone marrow recovery [CRi], 58%; ORR, 96%). In patients who achieved CR/CRi (n=92), median duration of CR/CRi was not reached; 90/92 patients (98%) achieved durable CR/CRi (lasting ≥12 cycles). PFS in patients with high-risk features was promising (Table 2), but it was numerically lower in the subset with del(17p)/mutated TP53 (54-month rate, 45% [95% CI, 25-64]). Serious AEs considered related to study treatment and second malignancies continued to be collected after completion of fixed-duration treatment. One AE of basal cell carcinoma occurred during this additional year of follow-up. In total, second malignancies have occurred in 8% of patients since completion of ibrutinib + venetoclax treatment. Conclusion: Ibrutinib-based retreatment results in the CAPTIVATE study show promising responses in patients needing subsequent therapy after receiving this all-oral, once-daily fixed-duration regimen for first-line treatment of CLL/SLL. With up to 5 years of follow-up, fixed-duration ibrutinib + venetoclax continues to provide deep remissions with clinically meaningful PFS, including in patients with high-risk genomic features.
Published: 2023

28. Defining Signaling Interactomes Involved in Non-Canonical Wnt Signaling By ROR1 or ROR2 in Hairy Cell Leukemia That Can Influence Cell Morphology and Migration

Author: Cring, Matthew, Widhopf, George, Ghia, Emanuela M, and Kipps, Thomas J
Subjects: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Hematology, Clinical Research, Biotechnology, Rare Diseases, Cancer, 2.1 Biological and endogenous factors, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Paediatrics and Reproductive Medicine, Immunology, Biochemistry and cell biology, Cardiovascular medicine and haematology, Paediatrics
Abstract: Receptor tyrosine kinase-like orphan receptor 1 (ROR1) and 2 (ROR2) are highly conserved oncoembryonic surface proteins expressed on neoplastic cells of patients with a variety of human cancers, but not on most normal postpartum tissues. ROR1 and ROR2 are each a receptor for non-canonical Wnt factors that direct migration and planar cell polarity, which is essential for organ development. We developed humanized monoclonal antibodies (mAbs) each specific for ROR1 (UC-961) or ROR2 (6E6-70) and found the leukemia cells of patients with classic hairy cell leukemia (cHCL) or variant HCL (vHCL) express both ROR1 and ROR2 and that these receptors function in HCL non-canonical Wnt signaling (Widhopf, G. et al). We hypothesized that ROR1 and ROR2 each may associate with overlapping and distinctive sets of proteins, which may contribute to ROR1/2, ROR1, or ROR2 signaling in HCL. To test this hypothesis, we optimized conditions for generating immune precipitates (i.p.) with either UC-961 or 6E6-70, and examined the proteins of each i.p. via data dependent acquisition mass spectrometry. Consistent with the assumed capacity of each of these mAb to disrupt ROR1/2 heteroligomerization, we identified ROR1, but not ROR2, in i.p. generated using UC-961 and ROR2, but not ROR1, in i.p. generated using 6E6-70 on cell lysates of leukemia cells isolated from a patient with cHCL. In the anti-ROR1 i.p. we identified 1,414 proteins, 849 (60%) of which also were found in the anti-ROR2 i.p.. In the anti-ROR2 i.p. we identified 2,523 proteins, a third of which also were found in the ROR1 i.p.. Among proteins common to both anti-ROR1 and anti-ROR2 i.p. we noted hematopoietic cell-specific protein-1 (HS1 or HCLS1), which we found associated a SH3-binding motif that was dependent on a proline residue at position 841 of activated ROR1 in chronic lymphocytic leukemia (CLL); we found this SH3-binding motif was critical for ROR1-dependent Wnt5a-induced chemokine-directed migration ( Leukemia 12:2615, 2017). Also found common to both ROR1 and ROR2 in HCL were proteins that drive actin polymerization and cytoskeletal dynamics that influence cell morphology and migration. To validate that ROR2 itself was involved in binding HS1 and in enhancing migration, we generated mutant forms of ROR2, each harboring a proline-to-alanine mutation in one of several proline residues found in the proline-rich domain of ROR2. We transduced MEC1 cells, which lack ROR1 or ROR2, with lentivirus vectors encoding wild-type ROR2 or each one of several P-A mutants of ROR2. Flow cytometry confirmed that each of the transduced cells had comparable expression of surface ROR2. We generated anti-ROR2 i.p. using lysates of each and found that all but one of the mutant forms of ROR2 could bind to HS1 by immunoblot analysis. In contrast to wild-type ROR2, or other mutant forms of ROR2, expression of this mutant form of ROR2 could not enhance chemokine-directed migration relative to that of wild-type MEC1 cells. Collectively, our studies define signaling interactomes involved in non-canonical Wnt signaling by ROR1 and/or ROR2 in hairy cell leukemia and define a residue within ROR2 that is necessary for binding HS1 and facilitating cellular migration.
Published: 2023

29. The DLEU2/miR-15a/miR-16-1 cluster shapes the immune microenvironment of chronic lymphocytic leukemia

Author: Zhang, Ronghua, Khare, Priyanka, Banerjee, Priyanka, Ivan, Cristina, Schneider, Sarah, Barbaglio, Federica, Clise-Dwyer, Karen, Jensen, Vanessa Behrana, Thompson, Erika, Mendoza, Marisela, Chiorazzi, Nicholas, Chen, Shih-Shih, Yan, Xiao-Jie Joy, Jain, Nitin, Ghia, Paolo, Caligaris-Cappio, Federico, Mendonsa, Rima, Kasimsetty, Sashi, Swoboda, Ryan, Bayraktar, Recep, Wierda, William, Gandhi, Varsha, Calin, George A., Keating, Michael J., and Bertilaccio, Maria Teresa Sabrina
Published: 2024
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30. Response of treatment-naive brain metastases to stereotactic radiosurgery

Author: Ene, Chibawanye I., Abi Faraj, Christina, Beckham, Thomas H., Weinberg, Jeffrey S., Andersen, Clark R., Haider, Ali S., Rao, Ganesh, Ferguson, Sherise D., Alvarez-Brenkenridge, Christopher A., Kim, Betty Y. S., Heimberger, Amy B., McCutcheon, Ian E., Prabhu, Sujit S., Wang, Chenyang Michael, Ghia, Amol J., McGovern, Susan L., Chung, Caroline, McAleer, Mary Frances, Tom, Martin C., Perni, Subha, Swanson, Todd A., Yeboa, Debra N., Briere, Tina M., Huse, Jason T., Fuller, Gregory N., Lang, Frederick F., Li, Jing, Suki, Dima, and Sawaya, Raymond E.
Published: 2024
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31. Constraining models for the origin of ultra-high-energy cosmic rays with a novel combined analysis of arrival directions, spectrum, and composition data measured at the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Aloisio, R., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Mocellin, A. Bartz, Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Bianciotto, M., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Orchera, P. G. Brichetto, Briechle, F. L., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Caccianiga, L., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Convenga, F., Santos, D. Correia dos, Costa, P. J., Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, J. C. dos, Anjos, R. C. dos, Ebr, J., Ellwanger, F., Emam, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Evoli, C., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fernandes, A., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gaudu, C., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lema-Capeans, Y, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Merx, C., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Müller, A. L., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Parente, G., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Pereira, L. A. S., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shahvar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rodriguez, E., Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Simon, F., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Streich, A., Suárez-Durán, M., Suomijärvi, T., Supanitsky, A. D., Svozilikova, Z., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vlastimil, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yue, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The combined fit of the measured energy spectrum and shower maximum depth distributions of ultra-high-energy cosmic rays is known to constrain the parameters of astrophysical models with homogeneous source distributions. Studies of the distribution of the cosmic-ray arrival directions show a better agreement with models in which a fraction of the flux is non-isotropic and associated with the nearby radio galaxy Centaurus A or with catalogs such as that of starburst galaxies. Here, we present a novel combination of both analyses by a simultaneous fit of arrival directions, energy spectrum, and composition data measured at the Pierre Auger Observatory. We find that a model containing a flux contribution from the starburst galaxy catalog of around 20% at 40 EeV with a magnetic field blurring of around $20^\circ$ for a rigidity of 10 EV provides a fair simultaneous description of all three observables. The starburst galaxy model is favored with a significance of $4.5\sigma$ (considering experimental systematic effects) compared to a reference model with only homogeneously distributed background sources. By investigating a scenario with Centaurus A as a single source in combination with the homogeneous background, we confirm that this region of the sky provides the dominant contribution to the observed anisotropy signal. Models containing a catalog of jetted active galactic nuclei whose flux scales with the $\gamma$-ray emission are, however, disfavored as they cannot adequately describe the measured arrival directions.
Published: 2023
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32. Search for a correlation between the UHECRs measured by the Pierre Auger Observatory and the Telescope Array and the neutrino candidate events from IceCube and ANTARES

Author: Aublin J., Coleiro A., Kouchner A., Al Samarai I., Barbano A., Montaruli T., Schumacher L., Wiebusch C., Caccianiga L., Ghia P.L., Giaccari U., Golup G., Sagawa H., and Tinyakov P.
Subjects: Physics, QC1-999
Abstract: High-energy neutrinos are expected to be produced by the interaction of accelerated particles near the acceleration sites. For this reason, it is intresting to search for correlation in the arrival directions of ultra–high energy cosmic rays (UHECRs) and HE neutrinos. We present here the results of a search for correlations between UHECR events measured by the Pierre Auger Observatory and Telescope Array and high-energy neutrino candidate events from IceCube and ANTARES. We perform a cross-correlation analysis, where the angular separation between the arrival directions of UHECRs and neutrinos is scanned. When comparing the results with the expectations from a null hypothesis contemplating an isotropic distribution of neutrinos or of UHECR we obtain post-trial p-values of the order of ~ 10 2.
Published: 2019
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33. B-cell Receptor Pathway Mutations Are Infrequent in Patients with Chronic Lymphocytic Leukemia on Continuous Ibrutinib Therapy.

Author: Jones, Daniel, Cheung, Leo, Chong, Elizabeth, Kwei, Kevin, Dean, James, James, Danelle, Wiestner, Adrian, Woyach, Jennifer, Ghia, Paolo, Byrd, John, Ahn, Inhye, Moreno, Carol, and OBrien, Susan
Subjects: Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Mutation, Agammaglobulinaemia Tyrosine Kinase, Receptors, Antigen, B-Cell
Abstract: PURPOSE: Acquired mutations in Brutons tyrosine kinase (BTK) or phospholipase C-γ2 (PLCG2) genes are associated with clinical progressive disease (PD) in patients with chronic lymphocytic leukemia (CLL) treated with BTK inhibitors. Data on mutation rates in patients without PD on ibrutinib treatment are limited. EXPERIMENTAL DESIGN: We evaluated frequency and time to detection of BTK and PLCG2 mutations in peripheral blood samples from 388 patients with previously untreated (n = 238) or relapsed/refractory (n = 150) CLL across five clinical trials. RESULTS: With median follow-up of 35 months (range, 0-72) without PD at last sampling, mutations in BTK (3%), PLCG2 (2%), or both genes (1%) were rare in previously untreated patients. With median follow-up of 35 months (range, 1-70) without PD at last sample, mutations in BTK (30%), PLCG2 (7%), or both genes (5%) were more common in patients with relapsed/refractory CLL. Median time to first detection of BTK C481S mutation was not reached in previously untreated patients and was >5 years in patients with relapsed/refractory CLL. Among patients evaluable at PD, previously untreated patients (n = 12) had lower rates than those with relapsed/refractory disease (n = 45) of BTK (25% vs. 49%) and PLCG2 mutations (8% vs. 13%). Time from first detection of BTK C481S mutation to PD was 11.3 months in 1 previously untreated patient and median 8.5 months (range, 0-35.7) among 23 patients with relapsed/refractory CLL. CONCLUSIONS: This systematic investigation describes development of mutations over time in patients without PD and informs the potential clinical opportunity to optimize ongoing benefits for such patients.
Published: 2023

34. Outcomes in Patients with High-Risk Features after Fixed-Duration Ibrutinib plus Venetoclax: Phase II CAPTIVATE Study in First-Line Chronic Lymphocytic Leukemia.

Author: Allan, John, Flinn, Ian, Siddiqi, Tanya, Ghia, Paolo, Tam, Constantine, Barr, Paul, Elinder Camburn, Anna, Tedeschi, Alessandra, Badoux, Xavier, Jacobs, Ryan, Kuss, Bryone, Trentin, Livio, Zhou, Cathy, Szoke, Anita, Abbazio, Christopher, Wierda, William, and Kipps, Thomas
Subjects: Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Piperidines, Bridged Bicyclo Compounds, Heterocyclic
Abstract: PURPOSE: The CAPTIVATE study investigated first-line ibrutinib plus venetoclax for chronic lymphocytic leukemia in 2 cohorts: minimal residual disease (MRD)-guided randomized discontinuation (MRD cohort) and Fixed Duration (FD cohort). We report outcomes of fixed-duration ibrutinib plus venetoclax in patients with high-risk genomic features [del(17p), TP53 mutation, and/or unmutated immunoglobulin heavy chain (IGHV)] in CAPTIVATE. PATIENTS AND METHODS: Patients received three cycles of ibrutinib 420 mg/day then 12 cycles of ibrutinib plus venetoclax (5-week ramp-up to 400 mg/day). FD cohort patients (n = 159) received no further treatment. Forty-three MRD cohort patients with confirmed undetectable MRD (uMRD) after 12 cycles of ibrutinib plus venetoclax received randomized placebo treatment. RESULTS: Of 195 patients with known status of genomic risk features at baseline, 129 (66%) had ≥1 high-risk feature. Overall response rates were >95% regardless of high-risk features. In patients with and without high-risk features, respectively, complete response (CR) rates were 61% and 53%; best uMRD rates: 88% and 70% (peripheral blood) and 72% and 61% (bone marrow); 36-month progression-free survival (PFS) rates: 88% and 92%. In subsets with del(17p)/TP53 mutation (n = 29) and unmutated IGHV without del(17p)/TP53 mutation (n = 100), respectively, CR rates were 52% and 64%; uMRD rates: 83% and 90% (peripheral blood) and 45% and 80% (bone marrow); 36-month PFS rates: 81% and 90%. Thirty-six-month overall survival (OS) rates were >95% regardless of high-risk features. CONCLUSIONS: Deep, durable responses and sustained PFS seen with fixed-duration ibrutinib plus venetoclax are maintained in patients with high-risk genomic features, with similar PFS and OS to those without high-risk features. See related commentary by Rogers, p. 2561.
Published: 2023

35. Association of baseline ROR1 and ROR2 gene expression with clinical outcomes in the I-SPY2 neoadjuvant breast cancer trial

Author: Parker, Barbara A, Shatsky, Rebecca A, Schwab, Richard B, Wallace, Anne M, Wolf, Denise M, Hirst, Gillian L, Brown-Swigart, Lamorna, Esserman, Laura J, van ’t Veer, Laura J, Ghia, Emanuela M, Yau, Christina, and Kipps, Thomas J
Subjects: Clinical Research, Cancer, Genetics, Clinical Trials and Supportive Activities, Breast Cancer, Aetiology, 2.1 Biological and endogenous factors, Humans, Female, Breast Neoplasms, Neoadjuvant Therapy, Receptor Tyrosine Kinase-like Orphan Receptors, Neoplasm Recurrence, Local, Gene Expression, ROR1, ROR2, Breast cancer, I-SPY2, Outcomes, I-SPY 2 Consortium, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract: PurposeROR1 and ROR2 are Type 1 tyrosine kinase-like orphan receptors for Wnt5a that are associated with breast cancer progression. Experimental agents targeting ROR1 and ROR2 are in clinical trials. This study evaluated whether expression levels of ROR1 or ROR2 correlated with one another or with clinical outcomes.MethodsWe interrogated the clinical significance of high-level gene expression of ROR1 and/or ROR2 in the annotated transcriptome dataset from 989 patients with high-risk early breast cancer enrolled in one of nine completed/graduated/experimental and control arms in the neoadjuvant I-SPY2 clinical trial (NCT01042379).ResultsHigh ROR1 or high ROR2 was associated with breast cancer subtypes. High ROR1 was more prevalent among hormone receptor-negative and human epidermal growth factor receptor 2-negative (HR-HER2-) tumors and high ROR2 was less prevalent in this subtype. Although not associated with pathologic complete response, high ROR1 or high ROR2 each was associated with event-free survival (EFS) in distinct subtypes. High ROR1 associated with a worse EFS in HR + HER2- patients with high post-treatment residual cancer burden (RCB-II/III) (HR 1.41, 95% CI = 1.11-1.80) but not in patients with minimal post-treatment disease (RCB-0/I) (HR 1.85, 95% CI = 0.74-4.61). High ROR2 associated with an increased risk of relapse in patients with HER2 + disease and RCB-0/I (HR 3.46, 95% CI = 1.33-9.020) but not RCB-II/III (HR 1.07, 95% CI = 0.69-1.64).ConclusionHigh ROR1 or high ROR2 distinctly identified subsets of breast cancer patients with adverse outcomes. Further studies are warranted to determine if high ROR1 or high ROR2 may identify high-risk populations for studies of targeted therapies.
Published: 2023

36. Outcomes and prognostic factors in 3306 patients with relapsed/refractory chronic lymphocytic leukemia treated with ibrutinib outside of clinical trials: A nationwide study

Author: Gian Matteo Rigolin, Pier Paolo Olimpieri, Valentina Summa, Simone Celant, Lydia Scarfò, Maria Pia Ballardini, Antonio Urso, Silvia Gambara, Francesco Cavazzini, Paolo Ghia, Antonio Cuneo, and Pierluigi Russo
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Abstract We performed a cohort study that included all patients with relapsed/refractory chronic lymphocytic leukemia (R/R CLL) who received ibrutinib in the Italian National Health Service. With a median follow‐up of 42.2 months (IQR 30.8–54.6 months), the study involved 3306 patients with a median age of 72.1 years, of whom 42.6% had received ≥2 previous lines of treatment. The estimated 24‐month probabilities of being on treatment and alive were 57.9% (95% confidence interval [CI]: 59.6–56.2) and 76.6% (95% CI: 75.2–78.1), respectively. The median time to treatment discontinuation (TTD) was 31.3 months (95% CI: 29.5–33.5). Out of 3306 patients, 2015 (60.9%) discontinued treatment, with 993 cases attributed to death or disease progression (30.0% of all cases). Among the 1022 patients who discontinued treatment for reasons other than progression or death, 564 (17.1%) patients did so due to toxicity or medical decision, while 458 patients (13.8%) were lost to follow‐up. Multivariable analysis revealed that age, Eastern Cooperative Oncology Group Performance Status, the number of previous lines of therapy, refractoriness to the last treatment, and reduced renal function were associated with shorter TTD and overall survival (OS). The coexistence of 17p− and TP53 mutations had an independent unfavorable impact on TTD and OS. Nonstandard doses were associated with shorter TTD and advanced stage with shorter OS. The median OS postprogression and postdiscontinuation for other reasons were estimated at 12.9 (95% CI: 11.3–16.2) and 22.7 months (95% CI: 20.2–28.3), respectively. This large real‐world study shows that ibrutinib is an effective treatment for R/R CLL. Baseline patient characteristics and double‐hit TP53 aberrations were associated with inferior prognosis, and discontinuation due to CLL progression portended a poor outcome.
Published: 2024
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37. Pirtobrutinib monotherapy in Bruton tyrosine kinase inhibitor-intolerant patients with B-cell malignancies: results of the phase I/II BRUIN trial

Author: Nirav N. Shah, Michael Wang, Lindsey E. Roeker, Krish Patel, Jennifer A. Woyach, William G. Wierda, Chaitra S. Ujjani, Toby A. Eyre, Pier Luigi Z inzani, Alvaro J. Alencar, Paolo Ghia, Nicole Lamanna, Marc S. Hoffmann, Manish R. Patel, Ian Flinn, James N. Gerson, Shuo Ma, Catherine C. Coombs, Chan Y. Cheah, Ewa Lech-Maranda, Bita Fakhri, Won Seog Kim, Minal A. Barve, Jonathon B. Cohen, Wojciech Jurczak, Talha Munir, Meghan C. Thompson, Donald E. Tsai, Katherine Bao, Nicholas A. Cangemi, Jennifer F. Kherani, Richard A. Walgren, Hongmei Han, Amy S. Ruppert, and Jennifer R. Brown
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Bruton tyrosine kinase inhibitors (BTKi) have transformed the treatment of B-cell malignancies, but intolerance has often led to their discontinuation. The phase 1/2 BRUIN study evaluated pirtobrutinib, a highly selective non-covalent (reversible) BTKi, in patients with R/R B-cell malignancies (NCT03740529). Pirtobrutinib was investigated in 127 patients with intolerance to at least one prior BTKi therapy in the absence of progressive disease. The most common adverse event (AE) leading to BTKi discontinuation was cardiac disorders (n=40, 31.5%), specifically atrial fibrillation (n=30, 23.6%). The median follow-up was 17.4 months and the median time on pirtobrutinib was 15.3 months. The most common reasons for pirtobrutinib discontinuation were progressive disease (26.8%), AE (10.2%), or death (5.5%). The most frequent treatment-emergent AEs were fatigue (39.4%) and neutropenia (37.0%). Among patients who discontinued a prior BTKi for a cardiac issue, 75% had no recurrence of their cardiac AE. No patient discontinued pirtobrutinib for the same AE that led to discontinuation of the prior BTKi. In 78 CLL/SLL and 21 MCL patients intolerant to prior BTKi, ORR to pirtobrutinib was 76.9% and 81.0%, respectively. Median PFS for CLL/SLL was 28.4 months and was not estimable for MCL. These results suggest that pirtobrutinib was safe, well-tolerated, and an efficacious option in patients with prior BTKi-intolerance.
Published: 2024
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38. Therapeutic strategies and treatment sequencing in patients with chronic lymphocytic leukemia: An international study of ERIC, the European Research Initiative on CLL

Author: Thomas Chatzikonstantinou, Lydia Scarfò, Eva Minga, Georgios Karakatsoulis, Dimitra Chamou, Jana Kotaskova, Gloria Iacoboni, Christos Demosthenous, Elisa Albi, Miguel Alcoceba, Salem Al‐Shemari, Thérèse Aurran‐Schleinitz, Francesca Bacchiarri, Sofia Chatzileontiadou, Rosa Collado, Zadie Davis, Marcos Daniel deDeus Santos, Maria Dimou, Elena Dmitrieva, David Donaldson, Gimena Dos Santos, Barbara Dreta, Maria Efstathopoulou, Shaimaa El‐Ashwah, Alicia Enrico, Andrzej Frygier, Sara Galimberti, Andrea Galitzia, Eva Gimeno, Valerio Guarente, Romain Guieze, Sean Harrop, Eleftheria Hatzimichael, Yair Herishanu, José‐Ángel Hernández‐Rivas, Ozren Jaksic, Elżbieta Kalicińska, Kamel Laribi, Volkan Karakus, Arnon P. Kater, Bonnie Kho, Maria Kislova, Εliana Konstantinou, Maya Koren‐Michowitz, Ioannis Kotsianidis, Zuzana Kubova, Jorge Labrador, Deepesh Lad, Luca Laurenti, Thomas Longval, Alberto Lopez‐Garcia, Juan Marquet, Stanislava Maslejova, Carlota Mayor‐Bastida, Biljana Mihaljevic, Ivana Milosevic, Fatima Miras, Riccardo Moia, Marta Morawska, Uttam K. Nath, Almudena Navarro‐Bailón, Jacopo Olivieri, Irina Panovska‐Stavridis, Maria Papaioannou, Cheyenne Pierie, Anna Puiggros, Gianluigi Reda, Gian M. Rigolin, Rosa Ruchlemer, Mattia Schipani, Annett Schiwitza, Yandong Shen, Tereza Shokralla, Martin Simkovic, Svetlana Smirnova, Dina S. A. Soliman, Stephan Stilgenbauer, Tamar Tadmor, Kristina Tomic, Eric Tse, Theodoros Vassilakopoulos, Andrea Visentin, Candida Vitale, George Vrachiolias, Vojin Vukovic, Renata Walewska, Zhenshu Xu, Munci Yagci, Lucrecia Yañez, Mohamed Yassin, Jana Zuchnicka, David Oscier, Alessandro Gozzetti, Panagiotis Panagiotidis, Francesc Bosch, Paolo Sportoletti, Blanca Espinet, Gerassimos A. Pangalis, Viola M. Popov, Stephen Mulligan, Maria Angelopoulou, Fatih Demirkan, Tomas Papajík, Bella Biderman, Roberta Murru, Marta Coscia, Constantine Tam, Antonio Cuneo, Gianluca Gaidano, Rainer Claus, Niki Stavroyianni, Livio Trentin, Darko Antic, Lukas Smolej, Olga B. Kalashnikova, Mark Catherwood, Martin Spacek, Sarka Pospisilova, Michael Doubek, Eugene Nikitin, Anastasia Chatzidimitriou, Paolo Ghia, and Kostas Stamatopoulos
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Published: 2024
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39. Escape rooms: behavioural response of two invasive crayfish species under water decline scenarios

Author: Daniela Ghia, Gianluca Fea, Fabio Ercoli, and Roberto Sacchi
Subjects: dispersal behaviour, overland movement, climate warming, non-native species, climbing, Geography. Anthropology. Recreation, Physical geography, GB3-5030, Environmental sciences, GE1-350
Abstract: Climate change and invasive alien species pose a significant threat to biodiversity and the survival of native species. This study considered the impact of drought conditions on the escape behaviour through terrestrial dispersal ability of two invasive freshwater crayfish species, the red swamp crayfish (Procambarus clarkii) and signal crayfish (Pacifastacus leniusculus). Using an experimental design simulating drought conditions and Mediterranean summer temperatures, we tested the hypothesis that P. clarkii exhibits a greater tendency to terrestrial migration and a higher land-walking speed than the P. leniusculus. The results indicated that both species demonstrated strong escape behaviour, with P. clarkii showing escape success higher than P. leniusculus, and increasing with decreasing mean night temperature and crayfish weight. Although drought conditions did not trigger escape, invasive species showed increased resistance and the ability to move to more favourable environments, suggesting that drought is not an effective geographic barrier against the spread of these species. These results underline the importance of considering invasive species' ability to escape and climb as part of management and control strategies.
Published: 2024
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40. A Catalog of the Highest-Energy Cosmic Rays Recorded During Phase I of Operation of the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Allison, P., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Ave, M., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Beatty, J., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Bhatta, G., Biermann, P. L., Billoir, P., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Caccianiga, L., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Cester, R., Chinellato, J. A., Chirinos, J., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Santos, D. Correia dos, Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Dorofeev, A., Anjos, R. C. dos, Ebr, J., Eman, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harton, J., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Knapp, J., Kunka, N., Lachaud, C., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Müller, A. L., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shavar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Streich, A., Suárez-Durán, M., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Cendejas, L. M. Villaseñor, Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Younk, P., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: A catalog containing details of the highest-energy cosmic rays recorded through the detection of extensive air-showers at the Pierre Auger Observatory is presented with the aim of opening the data to detailed examination. Descriptions of the 100 showers created by the highest-energy particles recorded between 1 January 2004 and 31 December 2020 are given for cosmic rays that have energies in the range 78 EeV to 166 EeV. Details are also given of a further nine very-energetic events that have been used in the calibration procedure adopted to determine the energy of each primary. A sky plot of the arrival directions of the most energetic particles is shown. No interpretations of the data are offered., Comment: Article accepted for publication in ApJS
Published: 2022

41. Constraining the sources of ultra-high-energy cosmic rays across and above the ankle with the spectrum and composition data measured at the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Halim, A. Abdul, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Caccianiga, L., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Conte, M., Contreras, F., Convenga, F., Santos, D. Correia dos, Covault, C. E., Cristinziani, M., Sanchez, C. S. Cruz, Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, R. C. dos, Ebr, J., Eman, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Flaggs, B., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Majercakova, M., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Meinert, J., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Müller, A. L., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shavar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Streich, A., Suárez-Durán, M., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., and Zavrtanik, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: In this work we present the interpretation of the energy spectrum and mass composition data as measured by the Pierre Auger Collaboration above $6 \times 10^{17}$ eV. We use an astrophysical model with two extragalactic source populations to model the hardening of the cosmic-ray flux at around $5\times 10^{18}$ eV (the so-called "ankle" feature) as a transition between these two components. We find our data to be well reproduced if sources above the ankle emit a mixed composition with a hard spectrum and a low rigidity cutoff. The component below the ankle is required to have a very soft spectrum and a mix of protons and intermediate-mass nuclei. The origin of this intermediate-mass component is not well constrained and it could originate from either Galactic or extragalactic sources. To the aim of evaluating our capability to constrain astrophysical models, we discuss the impact on the fit results of the main experimental systematic uncertainties and of the assumptions about quantities affecting the air shower development as well as the propagation and redshift distribution of injected ultra-high-energy cosmic rays (UHECRs)., Comment: Submitted to JCAP
Published: 2022
Full Text: View/download PDF

42. Searches for Ultra-High-Energy Photons at the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Caccianiga, L., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Santos, D. Correia dos, Covault, C. E., Cristinziani, M., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, R. C. dos, Ebr, J., Eman, M., Engel, R., Epicoco, I., Erdmann, M., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Müller, A. L., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shavar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Streich, A., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., and Zehrer, L.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The Pierre Auger Observatory, being the largest air-shower experiment in the world, offers an unprecedented exposure to neutral particles at the highest energies. Since the start of data taking more than 18 years ago, various searches for ultra-high-energy (UHE, $E\gtrsim10^{17}\,\text{eV}$) photons have been performed: either for a diffuse flux of UHE photons, for point sources of UHE photons or for UHE photons associated with transient events like gravitational wave events. In the present paper, we summarize these searches and review the current results obtained using the wealth of data collected by the Pierre Auger Observatory., Comment: Review article accepted for publication in Universe (special issue on ultra-high energy photons)
Published: 2022
Full Text: View/download PDF

43. Search for photons above 10$^{19}$ eV with the surface detector of the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Abreu, P., Aglietta, M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Caccianiga, L., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Santos, D. Correia dos, Covault, C. E., Cristinziani, M., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, R. C. dos, Ebr, J., Eman, M., Engel, R., Epicoco, I., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Krohm, N., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Martins, M. A., Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Müller, A. L., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Shavar, M. Pourmohammad, Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Streich, A., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., and Zehrer, L.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We use the surface detector of the Pierre Auger Observatory to search for air showers initiated by photons with an energy above $10^{19}$ eV. Photons in the zenith angle range from 30$^\circ$ to 60$^\circ$ can be identified in the overwhelming background of showers initiated by charged cosmic rays through the broader time structure of the signals induced in the water-Cherenkov detectors of the array and the steeper lateral distribution of shower particles reaching ground. Applying the search method to data collected between January 2004 and June 2020, upper limits at 95\% CL are set to an $E^{-2}$ diffuse flux of ultra-high energy photons above $10^{19}$ eV, $2{\times}10^{19}$ eV and $4{\times}10^{19}$ eV amounting to $2.11{\times}10^{-3}$, $3.12{\times}10^{-4}$ and $1.72{\times}10^{-4}$ km$^{-2}$ sr$^{-1}$ yr$^{-1}$, respectively. While the sensitivity of the present search around $2 \times 10^{19}$ eV approaches expectations of cosmogenic photon fluxes in the case of a pure-proton composition, it is one order of magnitude above those from more realistic mixed-composition models. The inferred limits have also implications for the search of super-heavy dark matter that are discussed and illustrated., Comment: 21 pages, 8 figures
Published: 2022

44. Response of treatment-naive brain metastases to stereotactic radiosurgery

Author: Chibawanye I. Ene, Christina Abi Faraj, Thomas H. Beckham, Jeffrey S. Weinberg, Clark R. Andersen, Ali S. Haider, Ganesh Rao, Sherise D. Ferguson, Christopher A. Alvarez-Brenkenridge, Betty Y. S. Kim, Amy B. Heimberger, Ian E. McCutcheon, Sujit S. Prabhu, Chenyang Michael Wang, Amol J. Ghia, Susan L. McGovern, Caroline Chung, Mary Frances McAleer, Martin C. Tom, Subha Perni, Todd A. Swanson, Debra N. Yeboa, Tina M. Briere, Jason T. Huse, Gregory N. Fuller, Frederick F. Lang, Jing Li, Dima Suki, and Raymond E. Sawaya
Subjects: Science
Abstract: Abstract With improvements in survival for patients with metastatic cancer, long-term local control of brain metastases has become an increasingly important clinical priority. While consensus guidelines recommend surgery followed by stereotactic radiosurgery (SRS) for lesions >3 cm, smaller lesions (≤3 cm) treated with SRS alone elicit variable responses. To determine factors influencing this variable response to SRS, we analyzed outcomes of brain metastases ≤3 cm diameter in patients with no prior systemic therapy treated with frame-based single-fraction SRS. Following SRS, 259 out of 1733 (15%) treated lesions demonstrated MRI findings concerning for local treatment failure (LTF), of which 202 /1733 (12%) demonstrated LTF and 54/1733 (3%) had an adverse radiation effect. Multivariate analysis demonstrated tumor size (>1.5 cm) and melanoma histology were associated with higher LTF rates. Our results demonstrate that brain metastases ≤3 cm are not uniformly responsive to SRS and suggest that prospective studies to evaluate the effect of SRS alone or in combination with surgery on brain metastases ≤3 cm matched by tumor size and histology are warranted. These studies will help establish multi-disciplinary treatment guidelines that improve local control while minimizing radiation necrosis during treatment of brain metastasis ≤3 cm.
Published: 2024
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45. Disrupting pro-survival and inflammatory pathways with dimethyl fumarate sensitizes chronic lymphocytic leukemia to cell death

Author: Maria Elena Mantione, Miriam Meloni, Ilenia Sana, Jessica Bordini, Martina Del Nero, Michela Riba, Pamela Ranghetti, Eleonora Perotta, Paolo Ghia, Lydia Scarfò, and Marta Muzio
Subjects: Cytology, QH573-671
Abstract: Abstract Microenvironmental signals strongly influence chronic lymphocytic leukemia (CLL) cells through the activation of distinct membrane receptors, such as B-cell receptors, and inflammatory receptors, such as Toll-like receptors (TLRs). Inflammatory pathways downstream of these receptors lead to NF-κB activation, thus protecting leukemic cells from apoptosis. Dimethyl fumarate (DMF) is an anti-inflammatory and immunoregulatory drug used to treat patients with multiple sclerosis and psoriasis in which it blocks aberrant NF-κB pathways and impacts the NRF2 antioxidant circuit. Our in vitro analysis demonstrated that increasing concentrations of DMF reduce ATP levels and lead to the apoptosis of CLL cells, including cell lines, splenocytes from Eµ-TCL1-transgenic mice, and primary leukemic cells isolated from the peripheral blood of patients. DMF showed a synergistic effect in association with BTK inhibitors in CLL cells. DMF reduced glutathione levels and activated the NRF2 pathway; gene expression analysis suggested that DMF downregulated pathways related to NFKB and inflammation. In primary leukemic cells, DMF disrupted the TLR signaling pathways induced by CpG by reducing the mRNA expression of NFKBIZ, IL6, IL10 and TNFα. Our data suggest that DMF targets a vulnerability of CLL cells linked to their inflammatory pathways, without impacting healthy donor peripheral blood mononuclear cells.
Published: 2024
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46. Cosmological implications of photon-flux upper limits at ultra-high energies in scenarios of Planckian-interacting massive particles for dark matter

Author: The Pierre Auger Collaboration, Abreu, P., Aglietta, M., Albury, J. M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Batista, R. Alves, Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Botti, A. M., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Caballero-Mora, K. S., Caccianiga, L., Canfora, F., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Santos, D. Correia dos, Covault, C. E., Dasso, S., Daumiller, K., Dawson, B. R., Day, J. A., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., del Río, M., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, R. C. dos, Dova, M. T., Ebr, J., Engel, R., Epicoco, I., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Vegas, A. L. Garcia, Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hill, G. C., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mostafá, M., Müller, A. L., Muller, M. A., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Pirronello, V., Platino, M., Pont, B., Pothast, M., Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento-Cano, C., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Streich, A., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Wahlberg, H., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., Zehrer, L., and Aloisio, R.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology
Abstract: Using the data of the Pierre Auger Observatory, we report on a search for signatures that would be suggestive of super-heavy particles decaying in the Galactic halo. From the lack of signal, we present upper limits for different energy thresholds above ${\gtrsim}10^8$\,GeV on the secondary by-product fluxes expected from the decay of the particles. Assuming that the energy density of these super-heavy particles matches that of dark matter observed today, we translate the upper bounds on the particle fluxes into tight constraints on the couplings governing the decay process as a function of the particle mass. Instantons, which are non-perturbative solutions to Yang-Mills equations, can give rise to decay channels otherwise forbidden and transform stable particles into meta-stable ones. Assuming such instanton-induced decay processes, we derive a bound on the reduced coupling constant of gauge interactions in the dark sector: $\alpha_X \lesssim 0.09$, for $10^{9} \lesssim M_X/\text{GeV} < 10^{19}$. Conversely, we obtain that, for instance, a reduced coupling constant $\alpha_X = 0.09$ excludes masses $M_X \gtrsim 3\times 10^{13}~$GeV. In the context of dark matter production from gravitational interactions alone during the reheating epoch, we derive constraints on the parameter space that involves, in addition to $M_X$ and $\alpha_X$, the Hubble rate at the end of inflation, the reheating efficiency, and the non-minimal coupling of the Higgs with curvature., Comment: 15 pages, 8 figures, Accompanying paper of arXiv:2203.08854, accepted for publication in Phys. Rev. D
Published: 2022

47. Arrival Directions of Cosmic Rays above 32 EeV from Phase One of the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Abreu, P., Aglietta, M., Albury, J. M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Batista, R. Alves, Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Botti, A. M., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Caballero-Mora, K. S., Caccianiga, L., Canfora, F., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Santos, D. Correia dos, Covault, C. E., Dasso, S., Daumiller, K., Dawson, B. R., Day, J. A., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., del Río, M., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, R. C. dos, Dova, M. T., Ebr, J., Engel, R., Epicoco, I., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hill, G. C., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mostafá, M., Müller, A. L., Muller, M. A., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Pirronello, V., Platino, M., Pont, B., Pothast, M., Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Streich, A., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Wahlberg, H., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., and Zehrer, L.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: A promising energy range to look for angular correlation between cosmic rays of extragalactic origin and their sources is at the highest energies, above few tens of EeV ($1\:{\rm EeV}\equiv 10^{18}\:$eV). Despite the flux of these particles being extremely low, the area of ${\sim}\:3{,}000 \: \text{km}^2$ covered at the Pierre Auger Observatory, and the 17-year data-taking period of the Phase 1 of its operations, have enabled us to measure the arrival directions of more than 2,600 ultra-high energy cosmic rays above $32\:\text{EeV}$. We publish this data set, the largest available at such energies from an integrated exposure of $122{,}000 \: \text{km}^2\:\text{sr}\:\text{yr}$, and search it for anisotropies over the $3.4\pi$ steradians covered with the Observatory. Evidence for a deviation in excess of isotropy at intermediate angular scale, with ${\sim}\:15^\circ$ Gaussian spread or ${\sim}\:25^\circ$ top-hat radius, is obtained at the $4\:\sigma$ significance level for cosmic-ray energies above ${\sim}\:40\:\text{EeV}$., Comment: Published version, 33 pages, 10 figures. Dataset and analysis software available at https://doi.org/10.5281/zenodo.6504276
Published: 2022
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48. Investigating Hadronic Interactions at Ultra-High Energies with the Pierre Auger Observatory

Author: Goos, Isabel, Abreu, P., Aglietta, M., Albury, J. M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Batista, R. Alves, Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Botti, A. M., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Caballero-Mora, K. S., Caccianiga, L., Canfora, F., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Santos, D. Correia dos, Covault, C. E., Dasso, S., Daumiller, K., Dawson, B. R., Day, J. A., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., del Río, M., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, R. C. dos, Dova, M. T., Ebr, J., Engel, R., Epicoco, I., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Vegas, A. L. Garcia, Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hill, G. C., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mostafá, M., Müller, A. L., Muller, M. A., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Pirronello, V., Platino, M., Pont, B., Pothast, M., Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento-Cano, C., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Streich, A., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Wahlberg, H., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., and Zehrer, L.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract: The development of an extensive air shower depends not only on the nature of the primary ultra-high-energy cosmic ray but also on the properties of the hadronic interactions. For energies above those achievable in human-made accelerators, hadronic interactions are only accessible through the studies of extensive air showers, which can be measured at the Pierre Auger Observatory. With its hybrid detector design, the Pierre Auger Observatory measures both the longitudinal development of showers in the atmosphere and the lateral distribution of particles that arrive at the ground. This way, observables that are sensitive to hadronic interactions at ultra-high energies can be obtained. While the hadronic interaction cross-section can be assessed from the longitudinal profiles, the number of muons and their fluctuations measured with the ground detectors are linked to other physical properties. In addition to these direct studies, we discuss here how measurements of the atmospheric depth of the maximum of air-shower profiles and the characteristics of the muon signal at the ground can be used to test the self-consistency of the post-LHC hadronic models., Comment: Proceedings of VHEPU 56th Rencontres de Moriond 2022
Published: 2022

49. Characteristics and Clinical Outcomes of Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Receiving Ibrutinib for ≥5 Years in the RESONATE-2 Study

Author: Woyach, Jennifer A, Barr, Paul M, Kipps, Thomas J, Barrientos, Jacqueline C, Ahn, Inhye E, Ghia, Paolo, Girardi, Vincent, Hsu, Emily, Jermain, Mandy, and Burger, Jan A
Subjects: Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Orphan Drug, Cancer, Rare Diseases, Hematology, Lymphoma, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, ibrutinib, chronic lymphocytic leukemia, long-term outcomes, Oncology and carcinogenesis
Abstract: Primary results from the phase 3 RESONATE-2 study demonstrated superior efficacy and tolerability with ibrutinib versus chlorambucil in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Here, we describe characteristics and outcomes of patients who received ibrutinib treatment for ≥5 years in RESONATE-2. Patients aged ≥65 years with previously untreated CLL/SLL, without del(17p), were randomly assigned 1:1 to once-daily ibrutinib 420 mg until disease progression/unacceptable toxicity (n = 136) or chlorambucil 0.5−0.8 mg/kg for ≤12 cycles (n = 133). Baseline characteristics in ibrutinib-randomized patients (n = 136) were generally similar between patients on ibrutinib treatment for ≥5 years (n = 79) versus those on treatment for
Published: 2023

50. Disrupting pro-survival and inflammatory pathways with dimethyl fumarate sensitizes chronic lymphocytic leukemia to cell death

Author: Mantione, Maria Elena, Meloni, Miriam, Sana, Ilenia, Bordini, Jessica, Del Nero, Martina, Riba, Michela, Ranghetti, Pamela, Perotta, Eleonora, Ghia, Paolo, Scarfò, Lydia, and Muzio, Marta
Published: 2024
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