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4. Long-term follow-up (up to 11 years) of an Italian pediatric MS cohort treated with Natalizumab: a multicenter, observational study

Author

Baroncini, Damiano, Ghezzi, Angelo, Guaschino, Clara, Moiola, Lucia, Filippi, Massimo, Ianniello, Antonio, Pozzilli, Carlo, Lanzillo, Roberta, Brescia-Morra, Vincenzo, Margoni, Monica, Gallo, Paolo, Callari, Graziella, Grimaldi, Luigi, Lus, Giacomo, Calabrese, Massimiliano, Simone, Marta, Marfia, Girolama Alessandra, Rasia, Sarah, Cargnelutti, Daniela, Comi, Giancarlo, and Zaffaroni, Mauro

Published
2022
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5. Long-term Cognitive Outcomes and Socioprofessional Attainment in People With Multiple Sclerosis With Childhood Onset

Author

Portaccio, Emilio, Bellinvia, Angelo, Razzolini, Lorenzo, Pastò, Luisa, Goretti, Benedetta, Niccolai, Claudia, Fonderico, Mattia, Zaffaroni, Mauro, Pippolo, Lorena, Moiola, Lucia, Falautano, Monica, Celico, Claudia, Viterbo, Rossella, Patti, Francesco, Chisari, Clara, Gallo, Paolo, Riccardi, Alice, Borghi, Martina, Bertolotto, Antonio, Simone, Marta, Pozzilli, Carlo, Bianchi, Valentina, Roscio, Marco, Martinelli, Vittorio, Comi, Giancarlo, Filippi, Massimo, Trojano, Maria, Ghezzi, Angelo, and Amato, Maria Pia

Published
2022
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8. Natalizumab treatment shows low cumulative probabilities of confirmed disability worsening to EDSS milestones in the long-term setting

Author

Correale, Jorge, Caride, Alejandro, Deri, Norma H., Ballario, Carlos, Broadley, Simon, Kneebone, Chris, Barnett, Michael, Pollard, John, Hodgkinson, Suzanne, Kermode, Allan, Macdonell, Richard, King, John, Butzkueven, Helmut, Lechner-Scott, Jeannette, Saines, Noel, Slee, Mark, Plummer, Chris, Willekens, Barbara, Vanopdenbosch, Ludo, Belachew, Shibeshih, Phan-Ba, Rémy, Delvaux, Valérie, Bissay, Veronique, Debruyne, Jan, Decoo, Danny, Crols, Roeland, Symons, Anoek, Nagels, Guy, Van Pesch, Vincent, Sindic, Christian, Dubois, Benedicte, Medaer, Robert, D'Hooghe, Marie, Guillaume, Daniel, De Smet, Eric, Seeldrayers, Pierrette, Lysandropoulos, Andreas, Vokaer, Mathieu, Geens, Karine, Willems, Christina, Denayer, Pierre, Bureau, Michel, Retif, Cecile, Dupuis, Michel, Bouquiaux, Olivier, Vanderdonckt, Patrick, van Landegem, William, Caekebeke, Jo, Van Ingelghem, Erwin, Peeters, Katelijne, Gerard, Pascale, de Noordhout, Alain Maertens, Desfontaines, Philippe, Urbain, Etienne, Declercq, Inge, Van Wijmeersch, Bart, Vanroose, Erwin, Wibail, Alain, Barthomolé, Emmanuel, Ursell, Melanie, Sweet, Margaret Elizabeth, Howse, David, Jichici, Draga, Shawush, Melad, Namaka, Mike, Traboulsee, Anthony, Hashimoto, Stan, Lo, Raymond, Marchetti, Paul, Lapierre, Yves, Jacques, Francois, MacLean, Gregg, Bhan, Virender, Duquette, Pierre, Stewart, Bradley, Paulseth, John, Kremenchutzky, Marcelo, Vorobeychik, Galina, O'Connor, Paul, Grand'Maison, François, Havrdova, Eva, Meluzinová, Eva, Valis, Martin, Talab, Radomír, Stourac, Pavel, Zapletalová, Olga, Dufek, Michal, Sládková, Vladimíra, Novotna, Alena, Vancurová, Romana, Lhotaková, Libuse, Fiedler, Jiri, Vachova, Marta, Dolezil, David, Stetkarova, Ivana, Rehankova, Adela, Psenica, Petr, Ulehlova, Veronika, Feketova, Sona, Skoda, Ondrej, Färkkilä, Markus, Taneli, Sarasoja, Koivisto, Keijo, Seppä, Juha Matti, Airas, Laura, Elovaara, Irina, Hartikainen, Päivi, Pirttila, Tuula, Louchart, Pierre, Ille, Olivier, Thenint, Jean philippe, Godet, Etienne, Vioud, Marcel Maillet, Colamarino, Renato, Gugenheim, Michel, Grimaud, Jerome, Kopf, Audrey, Billy, Christophe, Huttin, Bernard, Borsotti, Jean paul, Devos, Philippe, Kendjuo, Jean bertin N, Verier, Albert, Chapuis, Stephane, Daluzeau, Nathalie, Angibaud, Gilles, Uriot, Marie-Sylvie Artaud, Ziegler, François, Sellal, François, Moulignier, Antoine, Lavenu, Isabelle, Ismail, Samir, Devy, Richard, Suceveanu, Manuel, Wagner, Marc, Marcel, Sebastien, Derouiche, Faycal, Mostoufizadehghalamfarsa, Sohrab, Delalande, Sophie, Ruggieri, Irene, Van Nieuwenhuyse, Catherine Bossu, Nifle, Chantal, Ondze, Basile, Vasilescu, Carmen Gurau, Vongsouthi, Cyrille, Coustans, Marc, Anne, Olivier, Amevigbe, Josephine, Servan, Jerome, Merienne, Marc, Eck, Philippe, Berroir, Stephane, Busson, Philippe, Barroso, Bruno, Larrieu, Jean-Marc, Giendaj, Catherine Louvet, Malkoun, Imad, Hautecoeur, Patrick, Kwiatkowski, Arnaud, Pouliquen, Andre, Garrigues, Guillaume, Delerue, Olivier, Giraud, Pierric, Gere, Julien, Vaunaize, Jean, Dereeper, Olivier, Seiller, Nicolas, Alsassa, Roger, Vlaicu, Mihaela, Neuville, Veronique, Faucheux, Jean Marc, Bernady, Patricia, Fanjaud, Guy, Viallet, François, Schroeter, Michael, Schlemilch-Paschen, Sylke, Lange, Thomas, Bohr, Kin-Arno, Jendroska, Klaus, Rehkopf, Elisabeth, Bergmann, Arnfin, Kleinschnitz, Christoph, Postert, Thomas, Scholz, Peter, Mauz, Uwe, Stratmann, Hubert, Siefjediers, Veneta, Prantl, Martin, Gehring, Klaus, Zellner, Ruth, Junge, Kathrin, Zellner, Anton, Bacay, Valerina, Schlegel, Eugen, Polzer, Udo, Strauss, Erik, Link, Andreas, Stenzel, Christoph, Freidel, Matthias, Drews, Joachim, Neudert, Christian, Schmitz, Frank, Jaeger, Joachim, Masri, Said, Heuberger, Wolfgang, Trausch, Beate, Ruhnke, Oliver, Scarel, Serena, Bach, Kathlen, Ernst, Michael, Landefeld, Harald, Richter, Nils, Schmidt, Stephan, Krause, Michaela, Dressel, Alezander, Ruth, Roland, Anvari, Kerstin, Gossling, Jens, Schenk, Christoph, Tiedge, Oliver, Bode, Lutz, Eder, Hans-Thomas, Pfeffer, Oliver, Krug, Reinhard, Lassek, Christoph, Fleischer, Eberhard, Meuth, Sven, Klotz, Luisa Hildegard, Peglau, Ines, Kukowski, Borries, Herting, Birgit, Guthke, Kersten, Schierenbeck, Jurgen, Brockmeier, Bernd, Albrecht, Holger, Wuttke, Matthias, Augspach-Hofmann, Regine, Gunther, Stefan, Redbrake, Martin, Franke, Christian, Buchner, Klaus, Gratz, Thomas, Horn, Rolf, Doemges, Frank, Schreiber, Martin, Brosch, Thomas, Horn, Markus, Kittlitz, Matthias, Vulturius, Gabriele, Hinse, Paul, Malessa, Rolf, Wiehler, Stephan, Katsarava, Zaza, Kastrup, Oliver, Kausch, Ulrich, Gullekes, Martin, Fickinger, Markus, Wenzel, Wilhelm, Botefur, Ingolf C., Reifschneider, Gerd, Rauer, Sebastian, Lang, Michael, Harms, Lutz, Eckhardt, Ulrich, Cursiefen, Simone, Linker, Ralf, Angstwurm, Klemens, Haas, Judith, Schuetze, Ivo, Rohm, Eva, Stienker-Fisse, H., Sailer, Michael, Bohringer, Johannes, Maurer, Mathias, Bause, Eberhard, Wersching, Ronald, Dachsel, Reinhardt, Domke, Sylke, Hoffman, Frank, Tackenberg, Bjorn, Roch, Kerstin, Ziebold, Uwe, Kallmann, Boris, Buehler, Bernhard, Faiss, Judith, Faiss, Juergen, Schimrigk, Sebastian, Menges, Christian, Knop, Karl Christian, Koehler, Wolfgang, Siever, Arno, Bufler, Johannes, Gramsl, Georg, Kuhnler, Benedicta, Maschke, Matthias, Stogbauer, Florian, Staude, Lisa, Bethke, Florian, Bitsch, Andreas, Harmjanz, Arndt D., Windsheimer, Jorg, Kieseier, Bernd C., Berkenfeld, Ralf, Tumani, Hayrettin, Kirsch, Michael, Wildemann, Brigitte, Daniels, Regina, Gottwald, Klaus, Elias, Wolfgang-Gerhard, Hoffmann, Olaf, Schwab, Matthias, Pilz, Christopher, Klostermann, Fabian, Hellwig, Kerstin, Berthele, Achim, Bayas, Antonios, Molitor, Daniel, Grothe, Christoph, Wagner, Bert, Karageorgiou, Klimentini, Mitsikostas, Dimosthenis, Kodounis, Antonios, Plaitakis, Andreas, Papadimitriou, Alexandros, Grigoriadis, Nikolaos, Vlaikidis, Nikolaos, Koutlas, Evaggelos, Kyritsis, Athanassios, Papathanassopoulos, Panagiotis, Makris, Nikolaos, Tavernarakis, Antonios, Scarpini, Elio, Montanari, Enrico, Marrosu, Maria Giovanna, Trojano, Maria, Amato, Maria Pia, Rottoli, Mariarosa, Lugaresi, Alessandra, Florio, Ciro, Gasperini, Claudio, Grimaldi, Luigi, Millefiorini, Enrico, Koudriavtseva, Tatiana, Perla, Franco, Mantegazza, Renato, Bertolotto, Antonio, Ghezzi, Angelo, Aguilar, Sandra Quinones, Eisenberg, Eli Skromne, Lopez, Leondardo Llamas, Estudillo, Rocio Marquez, Schrijver, H.M., Wittebol, M.C., Baart, J.C., van Golde, A.E.L., Hengstman, G.J.D., Pop, P.H.M., Bos (Geldrop), M., Medaer, R., Schyns-Soeterboek, Angelique, van der Zwart, A., van Diepen, A.J.H., Verheul, G.A.M., Verhagen, W.I.M., Bos (Helmond), M., Witjes, R.J.G.M., Sinnige, L.G.F., van Munster, E.Th.L., Sanders, E.A.C.M., van Dijl, Ron, Hupperts, R.M.M., Frequin, S.T.F.M., Visser, L.H., Henselmans, J.M.L., Moll, J.W.B., Midgard, Rune, Myhr, Kjell Morten, Edland, Astrid, Telstad, Wenche, Hognestad, Tone, Lund, Christian, Hovdal, Harald, Kamaljit, Kaur, Schepel, Jan, Hogenesch, Roelfien Ida, Schüler, Stephan, Odeh, Francis, Alstadhaug, Karl B., Korsgaard, Olav, Farbu, Elisabeth, Ingvaldsen, Teis Barclay, Soares (SCO), Diana, Rente, José, Guerra, José Manuel Costa, Morganho, Armando, Leitão, António, de Sá, João, Sá, Maria José, Marques, Pinto, Veloso, Mário, Baptista, Miguel Viana, Szilasiová, Jarmila, Copikova-Cudrakova, Daniela, Prochazkova, Lubica, Klimová, Eleonóra, Donath, Vladimir, Brozman, Miroslav, Ramo, Cristina, Ruiz, Domingo Pérez, Hernández, Carmen Calles, Sola, María Eugenia Marzo, Moro, Roberto Suarez, Vidal, Jose Antonio, Rodríguez, Ana Belén Caminero, Ozaeta, Gisela Martin, Nadal, Jordi Batlle, Esquide, Amaya Alvarez de Arcaya, Urtaza, Javier Olascoaga, Martínez-Yélamos, Sergio, Arbizu, Txomin, Torrenta, Lluis Ramio i, Boggild, Mike, Wilson, Martin, Al-Araji, Adnan, Nicholas, Richard, Harrower, Timothy, Redmond, Ian, Wolf, Tilo, Osei-Bonsu, Michael, Mazibrada, Gordon, Rog, David, Cottrell, David, Constantinescu, Cris, Gray, Orla, Belhag, Mohamed, Shehu, Abdullah, Rashid, Waqar, Duddy, Martin, Kappos, Ludwig, Wiendl, Heinz, Spelman, Tim, Pellegrini, Fabio, Chen, Yi, Dong, Qunming, and Koendgen, Harold

Published
2018
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9. International Pediatric MS Study Group Clinical Trials Summit

Author

Chitnis, Tanuja, Tardieu, Marc, Amato, Maria Pia, Banwell, Brenda, Bar-Or, Amit, Ghezzi, Angelo, Kornberg, Andrew, Krupp, Lauren B, Pohl, Daniela, Rostasy, Kevin, Tenembaum, Silvia, Waubant, Emmanuelle, and Wassmer, Evangeline

Subjects
Clinical Trials and Supportive Activities, Brain Disorders, Rare Diseases, Pediatric Research Initiative, Neurosciences, Patient Safety, Clinical Research, Multiple Sclerosis, Pediatric, Orphan Drug, Neurodegenerative, Autoimmune Disease, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Clinical Trials as Topic, Consensus Development Conferences as Topic, District of Columbia, Humans, Immunologic Factors, Internationality, Pediatrics, Research Report, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

ObjectivePediatric studies for new biological agents are mandated by recent legislation, necessitating careful thought to evaluation of emerging multiple sclerosis (MS) therapies in children with MS. Challenges include a small patient population, the lack of prior randomized clinical trials, and ethical concerns. The goal of this meeting was to assess areas of consensus regarding clinical trial design and outcome measures among academic experts involved in pediatric MS care and research.MethodsThe Steering Committee of the International Pediatric MS Study Group identified key focus areas for discussion. A total of 69 meeting attendees were assembled, including 35 academic experts. Regulatory and pharmaceutical representatives also attended, and provided input, which informed academic expert consensus decisions.ResultsThe academic experts agreed that clinical trials were necessary in pediatric MS to obtain pharmacokinetic, safety and efficacy data, and regulatory approval allowing for greater medication access. The academic experts agreed that relapse was an appropriate primary outcome measure for phase III pediatric trials. An international standardized cognitive battery was identified. The pros and cons of various trial designs were discussed. Guidelines surrounding MRI studies, pharmacokinetics, pharmacodynamics, and registries were developed. The academic experts agreed that given the limited subject pool, a stepwise approach to the launch of clinical trials for the most promising medications is necessary in order to ensure study completion. Alternative approaches could result in unethical exposure of patients to trial conditions without gaining knowledge.ConclusionConsensus points for conduct of clinical trials in the rare disease pediatric MS were identified amongst a panel of academic experts, informed by regulatory and industry stakeholders.

Published
2013

11. The Italian multiple sclerosis register

Author

Trojano, Maria, Bergamaschi, Roberto, Amato, Maria Pia, Comi, Giancarlo, Ghezzi, Angelo, Lepore, Vito, Marrosu, Maria Giovanna, Mosconi, Paola, Patti, Francesco, Ponzio, Michela, Zaratin, Paola, Battaglia, Mario Alberto, and on behalf of the Italian Multiple Sclerosis Register Centers Group

Published
2019
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18. Neurofilament Light Chain in Adult and Pediatric Multiple Sclerosis:A Promising Biomarker to Better Characterize Disease Activity and Personalize MS Treatment

Author

Ghezzi, Angelo, Neuteboom, R. F., Ghezzi, Angelo, and Neuteboom, R. F.

Abstract

Many biological markers have been explored in multiple sclerosis (MS) to better quantify disease burden and better evaluate response to treatments, beyond clinical and MRI data. Among these, neurofilament light chain (Nf-L), although non-specific for this disease and found to be increased in other neurological conditions, has been shown to be the most promising biomarker for assessing axonal damage in MS, with a definite role in predicting the development of MS in patients at the first neurological episode suggestive of MS, and also in a preclinical phase. There is strong evidence that Nf-L levels are increased more in relapsing versus stable MS patients, and that they predict future disease evolution (relapses, progression, MRI measures of activity/progression) in MS patients, providing information on response to therapy, helping to anticipate clinical decisions in patients with an apparently stable evolution, and identifying patient non-responders to disease-modifying treatments. Moreover, Nf-L can contribute to the better understanding of the mechanisms of demyelination and axonal damage in adult and pediatric MS. A fundamental requirement for its clinical use is the accurate standardization of normal values, corrected for confounding factors, in particular age, sex, body mass index, and presence of comorbidities. In this review, a guide is provided to update clinicians on the use of Nf-L in clinical activity.

Published
2023

19. Efficacy of fingolimod and interferon beta-1b on cognitive, MRI, and clinical outcomes in relapsing–remitting multiple sclerosis: an 18-month, open-label, rater-blinded, randomised, multicentre study (the GOLDEN study)

Author

Comi, Giancarlo, Patti, Francesco, Rocca, Maria Assunta, Mattioli, Flavia Caterina, Amato, Maria Pia, Gallo, Paolo, Centonze, Diego, Pozzilli, Carlo, Saccà, Francesco, Bergh, Florian Then, Bartezaghi, Marta, Turrini, Renato, Filippi, Massimo, Patti, Francesco, Chisari, Clara Grazia, Marfia, Girolama Alessandra, Centonze, Diego, Morra, Vincenzo Brescia, Capra, Ruggero, Pozzilli, Carlo, Bianchi, Valentina, Ghezzi, Angelo, Roscio, Marco, Comi, Giancarlo, Sangalli, Francesca, Pietrolongo, Erika, Francia, Ada, Danni, Maura Chiara, Nocentini, Ugo, Bramanti, Placido, Tedeschi, Gioacchino, Maimone, Davide, Grimaldi, Luigi Maria Edoardo, Scarpini, Elio Angelo, Uccelli, Antonio, Amato, Maria Pia, Rottoli, Mariarosa, Ruggieri, Stefano, Trojano, Maria, Bergamaschi, Roberto, Bergh, Florian Then, Buttmann, Mathias, Rieckmann, Peter, Safavi, Ali, and For the Golden Study Group

Published
2017
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20. A Comprehensive Review on Copemyl®

Author

Annovazzi, Pietro, Bertolotto, Antonio, Brescia Morra, Vincenzo, Gasperini, Claudio, Montanari, Enrico, Navarra, Pierluigi, Patti, Francesco, Sormani, Maria Pia, and Ghezzi, Angelo

Published
2017
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24. Pregnancy decision-making in women with multiple sclerosis treated with natalizumab: I: Fetal risks

Author

Portaccio, Emilio, Annovazzi, Pietro, Ghezzi, Angelo, Zaffaroni, Mauro, Moiola, Lucia, Martinelli, Vittorio, Lanzillo, Roberta, Brescia Morra, Vincenzo, Rinaldi, Francesca, Gallo, Paolo, Tortorella, Carla, Paolicelli, Damiano, Pozzilli, Carlo, De Giglio, Laura, Cavalla, Paola, Cocco, Eleonora, Marrosu, Maria Giovanna, Patti, Francesco, Solaro, Claudio, Bellantonio, Paolo, Uccelli, Antonio, Laroni, Alice, Pastò, Luisa, Giannini, Marta, Trojano, Maria, Comi, Giancarlo, and Amato, Maria Pia

Published
2018
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25. Pregnancy decision-making in women with multiple sclerosis treated with natalizumab: II: Maternal risks

Author

Portaccio, Emilio, Moiola, Lucia, Martinelli, Vittorio, Annovazzi, Pietro, Ghezzi, Angelo, Zaffaroni, Mauro, Lanzillo, Roberta, Brescia Morra, Vincenzo, Rinaldi, Francesca, Gallo, Paolo, Tortorella, Carla, Paolicelli, Damiano, Pozzilli, Carlo, De Giglio, Laura, Cavalla, Paola, Cocco, Eleonora, Marrosu, Maria Giovanna, Solaro, Claudio, Uccelli, Antonio, Laroni, Alice, Pastò, Luisa, Giannini, Marta, Trojano, Maria, Comi, Giancarlo, and Amato, Maria Pia

Published
2018
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29. Correction to: The Italian multiple sclerosis register

Author

Trojano, Maria, Bergamaschi, Roberto, Amato, Maria Pia, Comi, Giancarlo, Ghezzi, Angelo, Lepore, Vito, Marrosu, Maria Giovanna, Mosconi, Paola, Patti, Francesco, Ponzio, Michela, Zaratin, Paola, Battaglia, Mario Alberto, and Italian Multiple Sclerosis Register Centers Group

Published
2019
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30. Natalizumab treatment and pregnancy in multiple sclerosis: A reappraisal of maternal and infant outcomes after 6 years

Author

Portaccio, Emilio, primary, Pastò, Luisa, additional, Razzolini, Lorenzo, additional, Moiola, Lucia, additional, Martinelli, Vittorio, additional, Annovazzi, Pietro, additional, Ghezzi, Angelo, additional, Zaffaroni, Mauro, additional, Lanzillo, Roberta, additional, Brescia Morra, Vincenzo, additional, Rinaldi, Francesca, additional, Gallo, Paolo, additional, Gasperini, Claudio, additional, Paolicelli, Damiano, additional, Simone, Marta, additional, Pozzilli, Carlo, additional, De Giglio, Laura, additional, Cavalla, Paola, additional, Cocco, Eleonora, additional, Marrosu, Maria Giovanna, additional, Patti, Francesco, additional, Solaro, Claudio, additional, Comi, Giancarlo, additional, Filippi, Massimo, additional, Trojano, Maria, additional, and Amato, Maria Pia, additional

Published
2022
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32. Effect of fingolimod on health-related quality of life in paediatric patients with multiple sclerosis: results from the phase 3 PARADIGMS Study

Author

Krupp, Lauren, primary, Banwell, Brenda, additional, Chitnis, Tanuja, additional, Deiva, Kumaran, additional, Gaertner, Jutta, additional, Ghezzi, Angelo, additional, Huppke, Peter, additional, Waubant, Emmanuelle, additional, DeLasHeras, Virginia, additional, Azmon, Amin, additional, and Karan, Rajesh, additional

Published
2022
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34. Etiological research in pediatric multiple sclerosis: A tool to assess environmental exposures (PEQ-IT)

Author

Pilotto, Silvy, Gencarelli, Jessica, Bova, Stefania Maria, Gerosa, Leonardo, Baroncini, Damiano, Olivotto, Sara, Alfei, Enrico, Zaffaroni, Mauro, Suppiej, Agnese, Cocco, Eleonora, Trojano, Maria, Amato, Maria Pia, D'Alfonso, Sandra, Boneschi, Filippo Martinelli, Waubant, Emmanuelle, Ghezzi, Angelo, Bergamaschi, Roberto, and Pugliatti, Maura

Published
2021
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35. Guidelines from The Italian Neurological and Neuroradiological Societies for the use of magnetic resonance imaging in daily life clinical practice of multiple sclerosis patients

Author

Filippi, Massimo, Rocca, Maria A., Bastianello, Stefano, Comi, Giancarlo, Gallo, Paolo, Gallucci, Massimo, Ghezzi, Angelo, Marrosu, Maria Giovanna, Minonzio, Giorgio, Pantano, Patrizia, Pozzilli, Carlo, Tedeschi, Gioacchino, Trojano, Maria, Falini, Andrea, and De Stefano, Nicola

Published
2013
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36. Etiological research in pediatric multiple sclerosis: A tool to assess environmental exposures (PEDiatric Italian Genetic and enviRonment ExposurE Questionnaire)

Author

Pilotto, Silvy, primary, Gencarelli, Jessica, additional, Bova, Stefania, additional, Gerosa, Leonardo, additional, Baroncini, Damiano, additional, Olivotto, Sara, additional, Alfei, Enrico, additional, Zaffaroni, Mauro, additional, Suppiej, Agnese, additional, Cocco, Eleonora, additional, Trojano, Maria, additional, Amato, Maria Pia, additional, D'Alfonso, Sandra, additional, Martinelli-Boneschi, Filippo, additional, Waubant, Emmanuelle, additional, Ghezzi, Angelo, additional, Bergamaschi, Roberto, additional, and Pugliatti, Maura, additional

Published
2021
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37. Fingolimod versus interferon beta/glatiramer acetate after natalizumab suspension in multiple sclerosis

Author

Iaffaldano, Pietro, Lucisano, Giuseppe, Pozzilli, Carlo, Brescia Morra, Vincenzo, Ghezzi, Angelo, Millefiorini, Enrico, Patti, Francesco, Lugaresi, Alessandra, Zimatore, Giovanni Bosco, Marrosu, Maria Giovanna, Amato, Maria Pia, Bertolotto, Antonio, Bergamaschi, Roberto, Granella, Franco, Coniglio, Gabriella, Tedeschi, Gioacchino, Sola, Patrizia, Lus, Giacomo, Ferrò, Maria Teresa, Iuliano, Gerardo, Corea, Francesco, Protti, Alessandra, Cavalla, Paola, Guareschi, Angelica, Rodegher, Mariaemma, Paolicelli, Damiano, Tortorella, Carla, Lepore, Vito, Prosperini, Luca, Saccà, Francesco, Baroncini, Damiano, Comi, Giancarlo, and Trojano, Maria

Published
2015
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39. Pregnancy in multiple sclerosis women with relapses in the year before conception increases the risk of long-term disability worsening

Author

Portaccio, Emilio, primary, Tudisco, Laura, additional, Pastò, Luisa, additional, Razzolini, Lorenzo, additional, Fonderico, Mattia, additional, Bellinvia, Angelo, additional, Ghezzi, Angelo, additional, Annovazzi, Pietro, additional, Zaffaroni, Mauro, additional, Moiola, Lucia, additional, Martinelli, Vittorio, additional, Chisari, Clara Grazia, additional, Patti, Francesco, additional, Mancardi, Gianluigi, additional, Pozzilli, Carlo, additional, De Giglio, Laura, additional, Totaro, Rocco, additional, Lugaresi, Alessandra, additional, Di Tommaso, Valeria, additional, Paolicelli, Damiano, additional, Cocco, Eleonora, additional, Marrosu, Maria Giovanna, additional, Comi, Giancarlo, additional, Filippi, Massimo, additional, Trojano, Maria, additional, Amato, Maria Pia, additional, Guaschino, Clara, additional, Protti, Alessandra, additional, Spreafico, Chiara, additional, Marazzi, Raffaella, additional, Cavalla, Paola, additional, Bergamaschi, Roberto, additional, Solaro, Claudio, additional, Caniatti, Luisa Maria, additional, Tola, Maria Rosaria, additional, Granella, Franco, additional, Immovilli, Paolo, additional, Annunziata, Pasquale, additional, Plewnia, Katrin, additional, Bartolozzi, Maria Letizia, additional, Guidi, Leonello, additional, Mazzoni, Monica, additional, De Luca, Giovanna, additional, Musu, Luigina, additional, and Fermo, Salvatore Lo, additional

Published
2021
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40. sj-docx-1-mso-10.1177_20552173211059048 - Supplemental material for Etiological research in pediatric multiple sclerosis: A tool to assess environmental exposures (PEDiatric Italian Genetic and enviRonment ExposurE Questionnaire)

Author

Pilotto, Silvy, Gencarelli, Jessica, Bova, Stefania, Gerosa, Leonardo, Baroncini, Damiano, Olivotto, Sara, Alfei, Enrico, Zaffaroni, Mauro, Suppiej, Agnese, Cocco, Eleonora, Trojano, Maria, Amato, Maria Pia, D'Alfonso, Sandra, Martinelli-Boneschi, Filippo, Waubant, Emmanuelle, Ghezzi, Angelo, Bergamaschi, Roberto, and Pugliatti, Maura

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-docx-1-mso-10.1177_20552173211059048 for Etiological research in pediatric multiple sclerosis: A tool to assess environmental exposures (PEDiatric Italian Genetic and enviRonment ExposurE Questionnaire) by Silvy Pilotto, Jessica Gencarelli, Stefania Bova, Leonardo Gerosa, Damiano Baroncini, Sara Olivotto, Enrico Alfei, Mauro Zaffaroni, Agnese Suppiej, Eleonora Cocco, Maria Trojano, Maria Pia Amato, Sandra D'Alfonso and Filippo Martinelli-Boneschi, Emmanuelle Waubant, Angelo Ghezzi, Roberto Bergamaschi, Maura Pugliatti in Multiple Sclerosis Journal ��� Experimental, Translational and Clinical

Published
2021
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41. sj-docx-2-mso-10.1177_20552173211059048 - Supplemental material for Etiological research in pediatric multiple sclerosis: A tool to assess environmental exposures (PEDiatric Italian Genetic and enviRonment ExposurE Questionnaire)

Author

Pilotto, Silvy, Gencarelli, Jessica, Bova, Stefania, Gerosa, Leonardo, Baroncini, Damiano, Olivotto, Sara, Alfei, Enrico, Zaffaroni, Mauro, Suppiej, Agnese, Cocco, Eleonora, Trojano, Maria, Amato, Maria Pia, D'Alfonso, Sandra, Martinelli-Boneschi, Filippo, Waubant, Emmanuelle, Ghezzi, Angelo, Bergamaschi, Roberto, and Pugliatti, Maura

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-docx-2-mso-10.1177_20552173211059048 for Etiological research in pediatric multiple sclerosis: A tool to assess environmental exposures (PEDiatric Italian Genetic and enviRonment ExposurE Questionnaire) by Silvy Pilotto, Jessica Gencarelli, Stefania Bova, Leonardo Gerosa, Damiano Baroncini, Sara Olivotto, Enrico Alfei, Mauro Zaffaroni, Agnese Suppiej, Eleonora Cocco, Maria Trojano, Maria Pia Amato, Sandra D'Alfonso and Filippo Martinelli-Boneschi, Emmanuelle Waubant, Angelo Ghezzi, Roberto Bergamaschi, Maura Pugliatti in Multiple Sclerosis Journal ��� Experimental, Translational and Clinical

Published
2021
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42. The introduction of new medications in pediatric multiple sclerosis:Open issues and challenges

Author

Ghezzi, Angelo, Amato, Maria Pia, Edan, Gilles, Hartung, Hans Peter, Havrdová, Eva Kubala, Kappos, Ludwig, Montalban, Xavier, Pozzilli, Carlo, Sørensen, Per Soelber, Trojano, Maria, Vermersch, Patrich, Comi, Giancarlo, Ghezzi, Angelo, Amato, Maria Pia, Edan, Gilles, Hartung, Hans Peter, Havrdová, Eva Kubala, Kappos, Ludwig, Montalban, Xavier, Pozzilli, Carlo, Sørensen, Per Soelber, Trojano, Maria, Vermersch, Patrich, and Comi, Giancarlo

Abstract

Disease-modifying drugs (DMDs) for multiple sclerosis (MS) have been evaluated in pediatric patients in observational studies demonstrating a similar, even better clinical effect compared to adults, with a similar safety. Only fingolimod has been tested in a randomized controlled trial (RCT) and is approved for pediatric multiple sclerosis (ped-MS). Numerous methodological, practical, and ethical issues underline that RCTs are difficult to conduct in ped-MS. This also creates a lack of safety information. To facilitate the availability of new agents in ped-MS, we encourage to develop a different approach based on pharmacokinetic/pharmacodynamic studies to yield information on optimal doses and implementation of obligatory registries to obtain information on safety as primary endpoint.

Published
2021

43. Risk of Persistent Disability in Patients With Pediatric-Onset Multiple Sclerosis

Author

Baroncini, Damiano, Simone, Marta, Iaffaldano, Pietro, Brescia Morra, Vincenzo, Lanzillo, Roberta, Filippi, Massimo, Romeo, Marzia, Patti, Francesco, Chisari, Clara Grazia, Cocco, Eleonora, Fenu, Giuseppe, Salemi, Giuseppe, Ragonese, Paolo, Inglese, Matilde, Cellerino, Maria, Margari, Lucia, Comi, Giancarlo, Zaffaroni, Mauro, Ghezzi, Angelo, Mirabella, Massimiliano, Mirabella, Massimiliano (ORCID:0000-0002-7783-114X), Baroncini, Damiano, Simone, Marta, Iaffaldano, Pietro, Brescia Morra, Vincenzo, Lanzillo, Roberta, Filippi, Massimo, Romeo, Marzia, Patti, Francesco, Chisari, Clara Grazia, Cocco, Eleonora, Fenu, Giuseppe, Salemi, Giuseppe, Ragonese, Paolo, Inglese, Matilde, Cellerino, Maria, Margari, Lucia, Comi, Giancarlo, Zaffaroni, Mauro, Ghezzi, Angelo, Mirabella, Massimiliano, and Mirabella, Massimiliano (ORCID:0000-0002-7783-114X)

Abstract

Importance: Availability of new disease-modifying therapies (DMTs) and changes of therapeutic paradigms have led to a general improvement of multiple sclerosis (MS) prognosis in adults. It is still unclear whether this improvement also involves patients with pediatric-onset MS (POMS), whose early management is more challenging. Objective: To evaluate changes in the prognosis of POMS over time in association with changes in therapeutic and managing standards. Design, setting, and participants: Retrospective, multicenter, observational study. Data were extracted and collected in May 2019 from the Italian MS Registry, a digital database including more than 59 000 patients. Inclusion criteria were MS onset before age 18 years, diagnosis before January 2014, and disease duration of at least 3 years. Exclusion criteria were primary progressive MS, Expanded Disability Status Scale (EDSS) score of at least 8 one year after onset, unavailability of diagnosis date, and less than 2 EDSS score evaluations. Eligible patients were 4704 patients with POMS. According to these criteria, we enrolled 3198 patients, excluding 1506. Exposures: We compared time to reach disability milestones by epoch of MS diagnosis (<1993, 1993-1999, 2000-2006, and 2007-2013), adjusting for possible confounders linked to EDSS evaluations and clinical disease activity. We then analyzed the difference among the 4 diagnosis epochs regarding demographic characteristics, clinical disease activity at onset, and DMTs management. Main outcomes and measures: Disability milestones were EDSS score 4.0 and 6.0, confirmed in the following clinical evaluation and in the last available visit. Results: We enrolled 3198 patients with POMS (mean age at onset, 15.2 years; 69% female; median time to diagnosis, 3.2 years; annualized relapse rate in first 1 and 3 years, 1.3 and 0.6, respectively), with a mean (SD) follow-up of 21.8 (11.7) years. Median survival times to reach EDSS score of 4.0 and 6.0 were 31.7 and 40.5 y

Published
2021

46. Brain macro- and microscopic damage in patients with paediatric MS

Author

Absinta, Martina, Rocca, Maria A., Moiola, Lucia, Ghezzi, Angelo, Milani, Nicoletta, Veggiotti, Pierangelo, Comi, Giancarlo, and Filippi, Massimo

Subjects
Multiple sclerosis -- Development and progression, Multiple sclerosis -- Demographic aspects, Multiple sclerosis -- Research, Brain damage -- Development and progression, Brain damage -- Demographic aspects, Brain damage -- Research, Magnetic resonance imaging -- Analysis, Health, Psychology and mental health
Published
2010

47. Postpartum relapses increase the risk of disability progression in multiple sclerosis: the role of disease modifying drugs

Author

Portaccio, Emilio, Ghezzi, Angelo, Hakiki, Bahia, Sturchio, Andrea, Martinelli, Vittorio, Moiola, Lucia, Patti, Francesco, Mancardi, Gian Luigi, Solaro, Claudio, Tola, Maria Rosaria, Pozzilli, Carlo, De Giglio, Laura, Totaro, Rocco, Lugaresi, Alessandra, De Luca, Giovanna, Paolicelli, Damiano, Marrosu, Maria Giovanna, Comi, Giancarlo, Trojano, Maria, Amato, Maria Pia, Amato, MP, Portaccio, E, Hakiki, B, Sturchio, A, Pastò, L, Giannini, M, Razzolini, L, Piscolla, E, Siracusa, G, Ghezzi, A, Rizzo, A, Zaffaroni, M, Martinelli, V, Radaelli, M, Moiola, L, Comi, G, Protti, A, Spreafico, C, Marazzi, R, Cavalla, P, Masera, S, Bergamaschi, R, Mancardi, G, Capello, E, Solaro, C, Tola, MR, Caniatti, L, Granella, F, Immovilli, P, Annunziata, P, De Santi, L, Plewnia, K, Guidi, L, Bartolozzi, ML, Mazzoni, M., Pozzilli, C, De Giglio, L, Totaro, R, Carolei, A, Rossi, M, Lugaresi, A, De Luca, G., Di Tommaso, V, Trojano, M, Paolicelli, D, Carrozzo, A, DʼOnghia, M, Marrosu, MG, Musu, L, Patti, F, Carmela, L, and Lo Fermo, S

Published
2014
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49. Treatment of Relapsing-Remitting Multiple Sclerosis After 24 Doses of Natalizumab: Evidence From an Italian Spontaneous, Prospective, and Observational Study (the TY-STOP Study)

Author

Clerico, Marinella, Schiavetti, Irene, De Mercanti, Stefania F., Piazza, Federico, Gned, Dario, Morra, Vincenzo Brescia, Lanzillo, Roberta, Ghezzi, Angelo, Bianchi, Anna, Salemi, Giuseppe, Realmuto, Sabrina, Sola, Patrizia, Vitetta, Francesca, Cavalla, Paola, Paolicelli, Damiano, Trojano, Maria, Sormani, Maria Pia, and Durelli, Luca

Published
2014
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50. Long-term results of immunomodulatory treatment in children and adolescents with multiple sclerosis: the Italian experience

Author

Ghezzi, Angelo, Amato, Maria Pia, Annovazzi, Pietro, Capobianco, Marco, Gallo, Paolo, La Mantia, Loredana, Marrosu, Maria Giovanna, Martinelli, Vittorio, Milani, Nicoletta, Moiola, Lucia, Patti, Francesco, Pozzilli, Carlo, Trojano, Maria, Zaffaroni, Mauro, Comi, Giancarlo, and The ITEMS (Immunomodulatory Treatment of Early-onset MS) Group

Published
2009
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