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Novel ultrathin Cd-Ag-MOF@ZnO composite nanoribbons (Ut-Nr Cd-Ag-MOF@ZnO C) were prepared and characterized in this research to serve as organocatalyst in Hantzsch condensation for selective synthesis of asymmetric polyhydroquinolines through a one-pot multi-component condensation reaction of various substituted arylaldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ammonium acetate and ethyl acetoacetate under solvent-free conventional heating in relatively short reaction times. The developed catalysts were easily recycled and reutilized at least three times under optimized reaction conditions with no noticeable decline in their initial catalytic activities. Operational simplicity and environmental compatibility, combined with the application of a reusable and affordable heterogeneous catalyst, significant efficiency, relatively short reaction time, and good yield are among the main characteristics of the proposed synthetic approach. [ABSTRACT FROM AUTHOR]

6-Mercaptopurine (6-MP) widely used as an administrated chemotherapeutic agent for the treatment of various cancers and inflammatory bowel diseases. However, due to its numerous side effects, the widespread use of this drug has decreased. Therefore, from the point of view of human health control, the 6-MP determination in biological matrices is of great significance. The current attempt was made to produce magnetic core–shell Fe3O4@SiO2/MWCNT nanocomposite (MCFSMW) in order to construct a novel selective and sensitive electrochemical 6-MP sensor. The characteristics of synthesized nanocomposite was determined by X-ray Diffraction, Fourier Transform Infrared Spectrometry, Scanning Electron Microscopy, and Energy-Dispersive X-ray. The sensor fabrication was based on the surface modification of screen-printed electrode (SPE) with MCFSMW (MCFSMW/SPE). The MCFSMW/SPE possessed an appropriate response and an appreciable electrocatalytic behaviors towards the 6-MP detection. There was a significant enhancement in the 6-MP electro-oxidation signal on the MCFSMW/SPE surface than on the bare SPE. The proposed protocol was explored by chronoamperometry, cyclic voltammetry, and differential pulse voltammetry (DPV). The DPV findings clarified a broad linear relationship between 6-MP concentration and peak height ranged from 0.08 to 235.0 µM with a limit of detection as narrow as 0.02 µM. The practical applicability of MCFSMW/SPE was confirmed by sensing 6-MP in biological matrices. [ABSTRACT FROM AUTHOR]

6-thioguanine (6-TG) is an anticancer drug with narrow safe dose range and intense toxic reactions, so it is urgently necessary to evaluate its clinical usage. Therefore, from the point of view of human health control, the 6-TG determination in biological matrices is of great significance. The current attempt was made to produce magnetic core–shell Fe3O4@SiO2/MWCNT nanocomposite (MCFSMW) to construct a novel selective and sensitive electrochemical 6-TG sensor. The characteristics of synthesized nanocomposite were determined by X-ray Diffraction, Fourier Transform Infrared Spectrometry, Scanning Electron Microscopy and Energy-Dispersive X-ray. The sensor fabrication was based on the surface modification of screen-printed electrode (SPE) with MCFSMW (MCFSMW/SPE). The MCFSMW/SPE possessed an appropriate response and an appreciable electrooxidation behaviors toward the 6-TG detection. There was a significant enhancement in the 6-TG electro-oxidation signal on the MCFSMW/SPE surface compared to the bare SPE. The proposed protocol was explored by chronoamperometry, cyclic voltammetry, and differential pulse voltammetry (DPV). The DPV findings clarified a broad linear relationship between the 6-TG concentrations and the peak height ranged from 0.01 to 280.0 µM with a limit of detection as narrow as 1.0 nM. The practical potency of MCFSMW/SPE was confirmed by sensing of 6-TG in the biological matrices. [ABSTRACT FROM AUTHOR]