AbstractVarious methods have been used to treat Alzheimer’s disease, but recently, the use of medicinal plants and the combination of their extracts and active substances with nanoparticles have been considered. Determination of anti-Alzheimer properties of silver nanoparticles synthesized by the Pimpinella anisum seed extract may be the novelty of this research. Nanoparticles were confirmed by UV–Vis, FTIR, SEM, EDAX, TEM, DLS, and XRD analysis. The antioxidant effects were determined by DPPH and ABTS and the inhibitory effects on the production of amyloid nanofibrils were determined by Congored assay. Nanoparticles were spherical with a diameter ranging from 40 to 60 nm. The highest antioxidant effect was observed at 500 and the highest inhibition of amyloid production was observed at 100 μg/mL of nanoparticles. Anise-AgNPs with antioxidant and inhibitory properties for amyloid production could be introduced as a suitable candidate for reducing the side effects of Alzheimer’s disease. [ABSTRACT FROM AUTHOR]