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Background: Although an optimal screening model is still under investigation, pre-eclampsia is a leading cause of perinatal morbidity. The association between cancer-antigen-125 (CA-125) and pre-eclampsia has been discussed in several studies recently., Objective: We aimed to determine the association between CA-125 and preeclampsia and estimated fetal weight., Materials and Methods: This case-control study was performed on 30 pregnant women with pre-eclampsia who were homogenized in terms of age, body mass index, and gestational age with 30 normal pregnant women. Participants were recruited via convenience sampling. The level of CA-125 in blood at the time of termination of pregnancy was measured by Enzyme Linked Immunosorbent Assay. The urine sample was used to check proteinuria. Blood pressure and pregnancy outcomes were assessed and recorded., Results: The mean serum CA-125 level in study group was considerably higher than control group (p < 0.001). Elevating the level of CA-125 has increased the likelihood of pre-eclampsia by 1.5 times. A significant direct correlation was obtained between CA-125 level and the amount of urinary protein (r = 0.605, p < 0.001). Also, a significant but negative correlation was obtained between the CA-125 level and the estimated weight of the fetus (r = -0.593, p < 0.001)., Conclusion: Increasing the serum level of CA-125 with high sensitivity and specificity is significantly associated with the occurrence of pre-eclampsia and estimated fetal weight., Competing Interests: The authors declare no conflict of interest., (Copyright © 2024 Gholami et al.)

Nephrotic syndrome is characterized by the leakage of protein from the blood into the urine along with the triad of proteinuria, albuminuria, and peripheral edema. Loss of protein leads to the loss of immunoglobulin and complements. X-linked agammaglobulinemia (XLA), or Bruton disease, is a primary immunodeficiency disease caused by a defect in the development of B cells in the bone marrow and a low serum level of immunoglobulins. The present case involves a 12-year-old boy with nephrotic syndrome, osteomyelitis, and recurrent infections. We discovered that he had XLA. This report underscores the importance of considering inborn errors of immunity in cases of protein loss, such as nephrotic syndrome.

Introduction: Alzheimer's disease (AD) is one of the most common neurological disorders and, researchers believe that the impairment of oxidant-antioxidant system plays an important role in its progression. The PI3K/NRF2 pathway has particular importance in increasing the expression of antioxidants. Thus present study aimed to investigate the effect of eight weeks of aerobic training (AT) with vitamin C (VC) on the expression pathway of antioxidants in the hippocampus tissue of trimethyltin chloride (TMT) induced Alzheimer's Disease Rats., Methods: In this experimental study, 28 male Sprague-Dawley rats (age 14-16 months, weight 270-320 g) were injected 10 mg/kg TMT and were divided into (1) TMT (n = 7), (2) TMT + VC (n = 7), (3) TMT + AT (n = 7) and (4) TMT + VC + AT (n = 7) groups. Also, 7 healthy rats without any intervention selected as healthy control (HC) group to investigate the effects of TMT on research variables. Groups 3 and 4 ran on the treadmill for eight weeks, for 15-48 min at a speed of 10-24 m/min. Also, groups 2 and 4 received 4 mg/kg VC orally. To measure PI3K, Nrf2, SOD and catalase in the hippocampus tissue of rats, ELISA method were used. To analyze the data, one-way analysis of variance with Tukey's post- hoc tests were used (P ≤ 0.05)., Results: The hippocampal values of Nrf2 and SOD in TMT + VC, TMT + AT and TMT + VC + AT groups were higher than TMT group (P = 0.001). Catalase in TMT + AT and TMT + VC + AT groups was higher than TMT group (P = 0.001). Also, catalase and PI3K were higher in the TMT + VC + AT group than the TMT + VC group (P = 0.05). PI3K levels of TMT + VC + AT group were higher than TMT + AT group (P = 0.02)., Conclusion: It seems that AT and VC, both alone and in combination, play a role in improving the transcription pathway of antioxidants in the hippocampus tissue of TMT induced Alzheimer's disease Rats. Therefore, the combination of these two interventions is suggested to improve the antioxidant system., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier B.V.)

Background: Congenital agammaglobulinemia is the first primary immunodeficiency disorder characterized by a defect in B lymphocyte development and subsequently decreased immunoglobulin levels. These patients are prone to suffer from recurrent infections mostly involving the respiratory tract. In this study, we aimed to describe in detail respiratory tract complications as the most prominent clinical feature among agammaglobulinemic patients., Methods: A total number of 115 patients were included. Demographic, clinical, and genetic data were collected from the patients' medical records. Among the available patients, pulmonary function tests (PFTs) and/or high-resolution computed tomography (HRCT) were performed., Results: Respiratory tract complications (85.2%) especially pneumonia (62.6%) were the most prominent clinical features in our cohort. Among patients with abnormal PFT results (N = 19), a mixed respiratory pattern was observed in 36.8%. HRCT was carried out in 29 patients; Bhalla scoring-based evaluation of these patients indicated excellent (44.8%), followed by good (34.5%) and mild (20.7%) results. Bronchiectasis was found in 13 patients undergoing HRCT (44.8%). We found significant inverse correlations between the Bhalla score and incidence rate of pneumonia, as well as the presence of bronchiectasis. Patients with abnormal PFT results had statistically significant higher bronchiectasis frequency and lower Bhalla scores compared to those with normal results. Forty-one patients were deceased, and here, respiratory failure was the most common cause of death (45.5%)., Conclusion: High prevalence of respiratory tract infections among agammaglobulinemic patients and subsequent progression to permanent lung damage highlights the importance of implementing respiratory evaluation as part of routine follow-up program of agammaglobulinemic patients. Physicians should be aware of this and regularly monitor the respiratory function of these patients to allow for timely diagnosis and treatment initiation aiming to improve patients' prognosis and quality of life., (© 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.)

Objectives: The aetiology and molecular mechanisms of schizophrenia (SCZ) and paranoid personality disorder (PPD) are not yet clarified. The present study aimed to assess the role of mitochondrial complex I and cell bioenergetic pathways in the aetiology and characteristics of SCZ and PPD., Methods: mRNA levels of all genomic and mitochondrial genes which encode mitochondrial complex I subunits (44 genes) were assessed in blood in 634 SCZ, 340 PPD patients and 528 non-psychiatric subjects using quantitative real-time PCR, and associated comprehensive psychiatric, neurological and biochemical assessments., Results: Significant expression changes of 18 genes in SCZ patients and 11 genes in PPD patients were detected in mitochondrial complex I. Most of these genes were novel candidate genes for SCZ and PPD. Several correlations between mRNA levels and severity of symptoms, drug response, deficits in attention, working memory, executive functions and brain activities were found., Conclusions: Deregulations of both core and supernumerary subunits of complex I are involved in the aetiology of SCZ and PPD. These deregulations have effects on brain activity as well as disorder characteristics.