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1. Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people

Author

Poisson, Johanne, El-Sissy, Carine, Serret-Larmande, Arnaud, Smith, Nikaïa, Lebraud, Morgane, Augy, Jean-Loup, Conti, Catherine, Gonnin, Cécile, Planquette, Benjamin, Arlet, Jean-Benoît, Hermann, Bertrand, Charbit, Bruno, Pastre, Jean, Devaux, Floriane, Ladavière, Cyrielle, Lim, Lydie, Ober, Pauline, Cannovas, Johanna, Biard, Lucie, Gulczynski, Marie-Christelle, Blumenthal, Noémie, Péré, Hélène, Knosp, Camille, Gey, Alain, Benhamouda, Nadine, Murris, Juliette, Veyer, David, Tartour, Eric, Diehl, Jean-Luc, Duffy, Darragh, Paillaud, Elena, and Granier, Clémence

Published
2024
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2. Enteral citrulline supplementation versus placebo on SOFA score on day 7 in mechanically ventilated critically ill patients: the IMMUNOCITRE randomized clinical trial

Author

Tadié, Jean-Marc, Locher, Clara, Maamar, Adel, Reignier, Jean, Asfar, Pierre, Commereuc, Morgane, Lesouhaitier, Mathieu, Gregoire, Murielle, Le Pabic, Estelle, Bendavid, Claude, Moreau, Caroline, Diehl, Jean-Luc, Gey, Alain, Tartour, Eric, Le Tulzo, Yves, Thibault, Ronan, Terzi, Nicolas, Gacouin, Arnaud, Roussel, Mikael, Delclaux, Christophe, Tarte, Karin, and Cynober, Luc

Published
2023
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4. Differential predictive value of resident memory CD8+T cell subpopulations in non-small-cell lung cancer patients treated by immunotherapy

Author

Paolini, Léa, primary, Tran, Thi, additional, Corgnac, Stéphanie, additional, Villemin, Jean-Philippe, additional, Wislez, Marie, additional, Arrondeau, Jennifer, additional, Johannes, Ludger, additional, Ulmer, Jonathan, additional, Vieillard, Louis-Victorien, additional, Pineau, Joséphine, additional, Gey, Alain, additional, Quiniou, Valentin, additional, Barennes, Pierre, additional, Pham, Hang Phuong, additional, Gruel, Nadège, additional, Hasan, Milena, additional, Libri, Valentina, additional, Mella, Sébastien, additional, De Percin, Sixtine, additional, Boudou-Rouquette, Pascaline, additional, Cremer, Isabelle, additional, Blons, Hélène, additional, Leroy, Karen, additional, Laurent-Puig, Pierre, additional, De Saint Basile, Hortense, additional, Gibault, Laure, additional, Ravel, Patrice, additional, Chouaib, Fathia Mami-, additional, Goldwasser, François, additional, Fabre, Elizabeth, additional, Damotte, Diane, additional, and Tartour, Eric, additional

Published
2024
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7. Supplementary Data from Plasma CD27, a Surrogate of the Intratumoral CD27–CD70 Interaction, Correlates with Immunotherapy Resistance in Renal Cell Carcinoma

Author

Benhamouda, Nadine, primary, Sam, Ikuan, primary, Epaillard, Nicolas, primary, Gey, Alain, primary, Phan, Letuan, primary, Pham, Hang Phuong, primary, Gruel, Nadège, primary, Saldmann, Antonin, primary, Pineau, Joséphine, primary, Hasan, Milena, primary, Quiniou, Valentin, primary, Nevoret, Camille, primary, Verkarre, Virginie, primary, Libri, Valentina, primary, Mella, Sebastien, primary, Granier, Clémence, primary, Broudin, Chloe, primary, Ravel, Patrice, primary, De Guillebon, Eléonore, primary, Mauge, Laetitia, primary, Helley, Dominique, primary, Jabla, Bernd, primary, Chaput, Nathalie, primary, Albiges, Laurence, primary, Katsahian, Sandrine, primary, Adam, Julien, primary, Mejean, Arnaud, primary, Adotevi, Olivier, primary, Vano, Yann A., primary, Oudard, Stéphane, primary, and Tartour, Eric, primary

Published
2023
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8. Supplementary Figure from Plasma CD27, a Surrogate of the Intratumoral CD27–CD70 Interaction, Correlates with Immunotherapy Resistance in Renal Cell Carcinoma

Author

Benhamouda, Nadine, primary, Sam, Ikuan, primary, Epaillard, Nicolas, primary, Gey, Alain, primary, Phan, Letuan, primary, Pham, Hang Phuong, primary, Gruel, Nadège, primary, Saldmann, Antonin, primary, Pineau, Joséphine, primary, Hasan, Milena, primary, Quiniou, Valentin, primary, Nevoret, Camille, primary, Verkarre, Virginie, primary, Libri, Valentina, primary, Mella, Sebastien, primary, Granier, Clémence, primary, Broudin, Chloe, primary, Ravel, Patrice, primary, De Guillebon, Eléonore, primary, Mauge, Laetitia, primary, Helley, Dominique, primary, Jabla, Bernd, primary, Chaput, Nathalie, primary, Albiges, Laurence, primary, Katsahian, Sandrine, primary, Adam, Julien, primary, Mejean, Arnaud, primary, Adotevi, Olivier, primary, Vano, Yann A., primary, Oudard, Stéphane, primary, and Tartour, Eric, primary

Published
2023
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9. Supplementary Fig S1-S8 from Tim-3 Expression on Tumor-Infiltrating PD-1+CD8+ T Cells Correlates with Poor Clinical Outcome in Renal Cell Carcinoma

Author

Granier, Clémence, primary, Dariane, Charles, primary, Combe, Pierre, primary, Verkarre, Virginie, primary, Urien, Saïk, primary, Badoual, Cécile, primary, Roussel, Hélène, primary, Mandavit, Marion, primary, Ravel, Patrice, primary, Sibony, Mathilde, primary, Biard, Lucie, primary, Radulescu, Camélia, primary, Vinatier, Emeline, primary, Benhamouda, Nadine, primary, Peyromaure, Michael, primary, Oudard, Stéphane, primary, Méjean, Arnaud, primary, Timsit, Marc-Olivier, primary, Gey, Alain, primary, and Tartour, Eric, primary

Published
2023
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10. Supplementary Data from TIM-3 Dictates Functional Orientation of the Immune Infiltrate in Ovarian Cancer

Author

Fucikova, Jitka, primary, Rakova, Jana, primary, Hensler, Michal, primary, Kasikova, Lenka, primary, Belicova, Lucie, primary, Hladikova, Kamila, primary, Truxova, Iva, primary, Skapa, Petr, primary, Laco, Jan, primary, Pecen, Ladislav, primary, Praznovec, Ivan, primary, Halaska, Michael J., primary, Brtnicky, Tomas, primary, Kodet, Roman, primary, Fialova, Anna, primary, Pineau, Josephine, primary, Gey, Alain, primary, Tartour, Eric, primary, Ryska, Ales, primary, Galluzzi, Lorenzo, primary, and Spisek, Radek, primary

Published
2023
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11. Supplementary Table S1-S6 from Tim-3 Expression on Tumor-Infiltrating PD-1+CD8+ T Cells Correlates with Poor Clinical Outcome in Renal Cell Carcinoma

Author

Granier, Clémence, primary, Dariane, Charles, primary, Combe, Pierre, primary, Verkarre, Virginie, primary, Urien, Saïk, primary, Badoual, Cécile, primary, Roussel, Hélène, primary, Mandavit, Marion, primary, Ravel, Patrice, primary, Sibony, Mathilde, primary, Biard, Lucie, primary, Radulescu, Camélia, primary, Vinatier, Emeline, primary, Benhamouda, Nadine, primary, Peyromaure, Michael, primary, Oudard, Stéphane, primary, Méjean, Arnaud, primary, Timsit, Marc-Olivier, primary, Gey, Alain, primary, and Tartour, Eric, primary

Published
2023
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12. Data from Tim-3 Expression on Tumor-Infiltrating PD-1+CD8+ T Cells Correlates with Poor Clinical Outcome in Renal Cell Carcinoma

Author

Granier, Clémence, primary, Dariane, Charles, primary, Combe, Pierre, primary, Verkarre, Virginie, primary, Urien, Saïk, primary, Badoual, Cécile, primary, Roussel, Hélène, primary, Mandavit, Marion, primary, Ravel, Patrice, primary, Sibony, Mathilde, primary, Biard, Lucie, primary, Radulescu, Camélia, primary, Vinatier, Emeline, primary, Benhamouda, Nadine, primary, Peyromaure, Michael, primary, Oudard, Stéphane, primary, Méjean, Arnaud, primary, Timsit, Marc-Olivier, primary, Gey, Alain, primary, and Tartour, Eric, primary

Published
2023
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13. Supplementary methods from A Therapeutic Her2/neu Vaccine Targeting Dendritic Cells Preferentially Inhibits the Growth of Low Her2/neu–Expressing Tumor in HLA-A2 Transgenic Mice

Author

Tran, Thi, primary, Diniz, Mariana O., primary, Dransart, Estelle, primary, Gey, Alain, primary, Merillon, Nathalie, primary, Lone, Yu Chun, primary, Godefroy, Sylvie, primary, Sibley, Craig, primary, Ferreira, Luis CS, primary, Medioni, Jacques, primary, Oudard, Stephane, primary, Johannes, Ludger, primary, and Tartour, Eric, primary

Published
2023
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14. Supplementary Methods from The Soluble α Chain of Interleukin-15 Receptor: A Proinflammatory Molecule Associated with Tumor Progression in Head and Neck Cancer

Author

Badoual, Cécile, primary, Bouchaud, Grégory, primary, Agueznay, Nour El Houda, primary, Mortier, Erwan, primary, Hans, Stéphane, primary, Gey, Alain, primary, Fernani, Fahima, primary, Peyrard, Séverine, primary, -Puig, Pierre Laurent, primary, Bruneval, Patrick, primary, Sastre, Xavier, primary, Plet, Ariane, primary, Garrigue-Antar, Laure, primary, Quintin-Colonna, Françoise, primary, Fridman, Wolf H., primary, Brasnu, Daniel, primary, Jacques, Yannick, primary, and Tartour, Eric, primary

Published
2023
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15. Supplementary Figure 5 from The Soluble α Chain of Interleukin-15 Receptor: A Proinflammatory Molecule Associated with Tumor Progression in Head and Neck Cancer

Author

Badoual, Cécile, primary, Bouchaud, Grégory, primary, Agueznay, Nour El Houda, primary, Mortier, Erwan, primary, Hans, Stéphane, primary, Gey, Alain, primary, Fernani, Fahima, primary, Peyrard, Séverine, primary, -Puig, Pierre Laurent, primary, Bruneval, Patrick, primary, Sastre, Xavier, primary, Plet, Ariane, primary, Garrigue-Antar, Laure, primary, Quintin-Colonna, Françoise, primary, Fridman, Wolf H., primary, Brasnu, Daniel, primary, Jacques, Yannick, primary, and Tartour, Eric, primary

Published
2023
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16. Supplementary Table 2 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Badoual, Cécile, primary, Hans, Stéphane, primary, Merillon, Nathalie, primary, Van Ryswick, Cordélia, primary, Ravel, Patrice, primary, Benhamouda, Nadine, primary, Levionnois, Emeline, primary, Nizard, Mevyn, primary, Si-Mohamed, Ali, primary, Besnier, Nicolas, primary, Gey, Alain, primary, Rotem-Yehudar, Rinat, primary, Pere, Hélène, primary, Tran, Thi, primary, Guerin, Coralie L., primary, Chauvat, Anne, primary, Dransart, Estelle, primary, Alanio, Cécile, primary, Albert, Sebastien, primary, Barry, Beatrix, primary, Sandoval, Federico, primary, Quintin-Colonna, Françoise, primary, Bruneval, Patrick, primary, Fridman, Wolf H., primary, Lemoine, Francois M., primary, Oudard, Stephane, primary, Johannes, Ludger, primary, Olive, Daniel, primary, Brasnu, Daniel, primary, and Tartour, Eric, primary

Published
2023
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17. Supplementary Figure 5 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Badoual, Cécile, primary, Hans, Stéphane, primary, Merillon, Nathalie, primary, Van Ryswick, Cordélia, primary, Ravel, Patrice, primary, Benhamouda, Nadine, primary, Levionnois, Emeline, primary, Nizard, Mevyn, primary, Si-Mohamed, Ali, primary, Besnier, Nicolas, primary, Gey, Alain, primary, Rotem-Yehudar, Rinat, primary, Pere, Hélène, primary, Tran, Thi, primary, Guerin, Coralie L., primary, Chauvat, Anne, primary, Dransart, Estelle, primary, Alanio, Cécile, primary, Albert, Sebastien, primary, Barry, Beatrix, primary, Sandoval, Federico, primary, Quintin-Colonna, Françoise, primary, Bruneval, Patrick, primary, Fridman, Wolf H., primary, Lemoine, Francois M., primary, Oudard, Stephane, primary, Johannes, Ludger, primary, Olive, Daniel, primary, Brasnu, Daniel, primary, and Tartour, Eric, primary

Published
2023
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18. Supplementary Methods and Materials from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Badoual, Cécile, primary, Hans, Stéphane, primary, Merillon, Nathalie, primary, Van Ryswick, Cordélia, primary, Ravel, Patrice, primary, Benhamouda, Nadine, primary, Levionnois, Emeline, primary, Nizard, Mevyn, primary, Si-Mohamed, Ali, primary, Besnier, Nicolas, primary, Gey, Alain, primary, Rotem-Yehudar, Rinat, primary, Pere, Hélène, primary, Tran, Thi, primary, Guerin, Coralie L., primary, Chauvat, Anne, primary, Dransart, Estelle, primary, Alanio, Cécile, primary, Albert, Sebastien, primary, Barry, Beatrix, primary, Sandoval, Federico, primary, Quintin-Colonna, Françoise, primary, Bruneval, Patrick, primary, Fridman, Wolf H., primary, Lemoine, Francois M., primary, Oudard, Stephane, primary, Johannes, Ludger, primary, Olive, Daniel, primary, Brasnu, Daniel, primary, and Tartour, Eric, primary

Published
2023
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19. Supplementary Figure 3 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Badoual, Cécile, primary, Hans, Stéphane, primary, Merillon, Nathalie, primary, Van Ryswick, Cordélia, primary, Ravel, Patrice, primary, Benhamouda, Nadine, primary, Levionnois, Emeline, primary, Nizard, Mevyn, primary, Si-Mohamed, Ali, primary, Besnier, Nicolas, primary, Gey, Alain, primary, Rotem-Yehudar, Rinat, primary, Pere, Hélène, primary, Tran, Thi, primary, Guerin, Coralie L., primary, Chauvat, Anne, primary, Dransart, Estelle, primary, Alanio, Cécile, primary, Albert, Sebastien, primary, Barry, Beatrix, primary, Sandoval, Federico, primary, Quintin-Colonna, Françoise, primary, Bruneval, Patrick, primary, Fridman, Wolf H., primary, Lemoine, Francois M., primary, Oudard, Stephane, primary, Johannes, Ludger, primary, Olive, Daniel, primary, Brasnu, Daniel, primary, and Tartour, Eric, primary

Published
2023
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20. Data from The Soluble α Chain of Interleukin-15 Receptor: A Proinflammatory Molecule Associated with Tumor Progression in Head and Neck Cancer

Author

Badoual, Cécile, primary, Bouchaud, Grégory, primary, Agueznay, Nour El Houda, primary, Mortier, Erwan, primary, Hans, Stéphane, primary, Gey, Alain, primary, Fernani, Fahima, primary, Peyrard, Séverine, primary, -Puig, Pierre Laurent, primary, Bruneval, Patrick, primary, Sastre, Xavier, primary, Plet, Ariane, primary, Garrigue-Antar, Laure, primary, Quintin-Colonna, Françoise, primary, Fridman, Wolf H., primary, Brasnu, Daniel, primary, Jacques, Yannick, primary, and Tartour, Eric, primary

Published
2023
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21. Supplementary Figure 3 from The Soluble α Chain of Interleukin-15 Receptor: A Proinflammatory Molecule Associated with Tumor Progression in Head and Neck Cancer

Author

Badoual, Cécile, primary, Bouchaud, Grégory, primary, Agueznay, Nour El Houda, primary, Mortier, Erwan, primary, Hans, Stéphane, primary, Gey, Alain, primary, Fernani, Fahima, primary, Peyrard, Séverine, primary, -Puig, Pierre Laurent, primary, Bruneval, Patrick, primary, Sastre, Xavier, primary, Plet, Ariane, primary, Garrigue-Antar, Laure, primary, Quintin-Colonna, Françoise, primary, Fridman, Wolf H., primary, Brasnu, Daniel, primary, Jacques, Yannick, primary, and Tartour, Eric, primary

Published
2023
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22. Supplementary Figure 2 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Badoual, Cécile, primary, Hans, Stéphane, primary, Merillon, Nathalie, primary, Van Ryswick, Cordélia, primary, Ravel, Patrice, primary, Benhamouda, Nadine, primary, Levionnois, Emeline, primary, Nizard, Mevyn, primary, Si-Mohamed, Ali, primary, Besnier, Nicolas, primary, Gey, Alain, primary, Rotem-Yehudar, Rinat, primary, Pere, Hélène, primary, Tran, Thi, primary, Guerin, Coralie L., primary, Chauvat, Anne, primary, Dransart, Estelle, primary, Alanio, Cécile, primary, Albert, Sebastien, primary, Barry, Beatrix, primary, Sandoval, Federico, primary, Quintin-Colonna, Françoise, primary, Bruneval, Patrick, primary, Fridman, Wolf H., primary, Lemoine, Francois M., primary, Oudard, Stephane, primary, Johannes, Ludger, primary, Olive, Daniel, primary, Brasnu, Daniel, primary, and Tartour, Eric, primary

Published
2023
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23. Supplementary Figure 4 from The Soluble α Chain of Interleukin-15 Receptor: A Proinflammatory Molecule Associated with Tumor Progression in Head and Neck Cancer

Author

Badoual, Cécile, primary, Bouchaud, Grégory, primary, Agueznay, Nour El Houda, primary, Mortier, Erwan, primary, Hans, Stéphane, primary, Gey, Alain, primary, Fernani, Fahima, primary, Peyrard, Séverine, primary, -Puig, Pierre Laurent, primary, Bruneval, Patrick, primary, Sastre, Xavier, primary, Plet, Ariane, primary, Garrigue-Antar, Laure, primary, Quintin-Colonna, Françoise, primary, Fridman, Wolf H., primary, Brasnu, Daniel, primary, Jacques, Yannick, primary, and Tartour, Eric, primary

Published
2023
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24. Supplementary Tables 1-4 from The Soluble α Chain of Interleukin-15 Receptor: A Proinflammatory Molecule Associated with Tumor Progression in Head and Neck Cancer

Author

Badoual, Cécile, primary, Bouchaud, Grégory, primary, Agueznay, Nour El Houda, primary, Mortier, Erwan, primary, Hans, Stéphane, primary, Gey, Alain, primary, Fernani, Fahima, primary, Peyrard, Séverine, primary, -Puig, Pierre Laurent, primary, Bruneval, Patrick, primary, Sastre, Xavier, primary, Plet, Ariane, primary, Garrigue-Antar, Laure, primary, Quintin-Colonna, Françoise, primary, Fridman, Wolf H., primary, Brasnu, Daniel, primary, Jacques, Yannick, primary, and Tartour, Eric, primary

Published
2023
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25. Supplementary Figure 4 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Badoual, Cécile, primary, Hans, Stéphane, primary, Merillon, Nathalie, primary, Van Ryswick, Cordélia, primary, Ravel, Patrice, primary, Benhamouda, Nadine, primary, Levionnois, Emeline, primary, Nizard, Mevyn, primary, Si-Mohamed, Ali, primary, Besnier, Nicolas, primary, Gey, Alain, primary, Rotem-Yehudar, Rinat, primary, Pere, Hélène, primary, Tran, Thi, primary, Guerin, Coralie L., primary, Chauvat, Anne, primary, Dransart, Estelle, primary, Alanio, Cécile, primary, Albert, Sebastien, primary, Barry, Beatrix, primary, Sandoval, Federico, primary, Quintin-Colonna, Françoise, primary, Bruneval, Patrick, primary, Fridman, Wolf H., primary, Lemoine, Francois M., primary, Oudard, Stephane, primary, Johannes, Ludger, primary, Olive, Daniel, primary, Brasnu, Daniel, primary, and Tartour, Eric, primary

Published
2023
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26. Supplementary Figure 1 from The Soluble α Chain of Interleukin-15 Receptor: A Proinflammatory Molecule Associated with Tumor Progression in Head and Neck Cancer

Author

Badoual, Cécile, primary, Bouchaud, Grégory, primary, Agueznay, Nour El Houda, primary, Mortier, Erwan, primary, Hans, Stéphane, primary, Gey, Alain, primary, Fernani, Fahima, primary, Peyrard, Séverine, primary, -Puig, Pierre Laurent, primary, Bruneval, Patrick, primary, Sastre, Xavier, primary, Plet, Ariane, primary, Garrigue-Antar, Laure, primary, Quintin-Colonna, Françoise, primary, Fridman, Wolf H., primary, Brasnu, Daniel, primary, Jacques, Yannick, primary, and Tartour, Eric, primary

Published
2023
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27. Supplementary Figure 6 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Badoual, Cécile, primary, Hans, Stéphane, primary, Merillon, Nathalie, primary, Van Ryswick, Cordélia, primary, Ravel, Patrice, primary, Benhamouda, Nadine, primary, Levionnois, Emeline, primary, Nizard, Mevyn, primary, Si-Mohamed, Ali, primary, Besnier, Nicolas, primary, Gey, Alain, primary, Rotem-Yehudar, Rinat, primary, Pere, Hélène, primary, Tran, Thi, primary, Guerin, Coralie L., primary, Chauvat, Anne, primary, Dransart, Estelle, primary, Alanio, Cécile, primary, Albert, Sebastien, primary, Barry, Beatrix, primary, Sandoval, Federico, primary, Quintin-Colonna, Françoise, primary, Bruneval, Patrick, primary, Fridman, Wolf H., primary, Lemoine, Francois M., primary, Oudard, Stephane, primary, Johannes, Ludger, primary, Olive, Daniel, primary, Brasnu, Daniel, primary, and Tartour, Eric, primary

Published
2023
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28. Supplementary Table 1 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Badoual, Cécile, primary, Hans, Stéphane, primary, Merillon, Nathalie, primary, Van Ryswick, Cordélia, primary, Ravel, Patrice, primary, Benhamouda, Nadine, primary, Levionnois, Emeline, primary, Nizard, Mevyn, primary, Si-Mohamed, Ali, primary, Besnier, Nicolas, primary, Gey, Alain, primary, Rotem-Yehudar, Rinat, primary, Pere, Hélène, primary, Tran, Thi, primary, Guerin, Coralie L., primary, Chauvat, Anne, primary, Dransart, Estelle, primary, Alanio, Cécile, primary, Albert, Sebastien, primary, Barry, Beatrix, primary, Sandoval, Federico, primary, Quintin-Colonna, Françoise, primary, Bruneval, Patrick, primary, Fridman, Wolf H., primary, Lemoine, Francois M., primary, Oudard, Stephane, primary, Johannes, Ludger, primary, Olive, Daniel, primary, Brasnu, Daniel, primary, and Tartour, Eric, primary

Published
2023
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29. Supplementary Figure 1 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Badoual, Cécile, primary, Hans, Stéphane, primary, Merillon, Nathalie, primary, Van Ryswick, Cordélia, primary, Ravel, Patrice, primary, Benhamouda, Nadine, primary, Levionnois, Emeline, primary, Nizard, Mevyn, primary, Si-Mohamed, Ali, primary, Besnier, Nicolas, primary, Gey, Alain, primary, Rotem-Yehudar, Rinat, primary, Pere, Hélène, primary, Tran, Thi, primary, Guerin, Coralie L., primary, Chauvat, Anne, primary, Dransart, Estelle, primary, Alanio, Cécile, primary, Albert, Sebastien, primary, Barry, Beatrix, primary, Sandoval, Federico, primary, Quintin-Colonna, Françoise, primary, Bruneval, Patrick, primary, Fridman, Wolf H., primary, Lemoine, Francois M., primary, Oudard, Stephane, primary, Johannes, Ludger, primary, Olive, Daniel, primary, Brasnu, Daniel, primary, and Tartour, Eric, primary

Published
2023
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30. Supplementary Figure 2 from The Soluble α Chain of Interleukin-15 Receptor: A Proinflammatory Molecule Associated with Tumor Progression in Head and Neck Cancer

Author

Badoual, Cécile, primary, Bouchaud, Grégory, primary, Agueznay, Nour El Houda, primary, Mortier, Erwan, primary, Hans, Stéphane, primary, Gey, Alain, primary, Fernani, Fahima, primary, Peyrard, Séverine, primary, -Puig, Pierre Laurent, primary, Bruneval, Patrick, primary, Sastre, Xavier, primary, Plet, Ariane, primary, Garrigue-Antar, Laure, primary, Quintin-Colonna, Françoise, primary, Fridman, Wolf H., primary, Brasnu, Daniel, primary, Jacques, Yannick, primary, and Tartour, Eric, primary

Published
2023
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31. Supplementary Figure Legends 1-5 from The Soluble α Chain of Interleukin-15 Receptor: A Proinflammatory Molecule Associated with Tumor Progression in Head and Neck Cancer

Author

Badoual, Cécile, primary, Bouchaud, Grégory, primary, Agueznay, Nour El Houda, primary, Mortier, Erwan, primary, Hans, Stéphane, primary, Gey, Alain, primary, Fernani, Fahima, primary, Peyrard, Séverine, primary, -Puig, Pierre Laurent, primary, Bruneval, Patrick, primary, Sastre, Xavier, primary, Plet, Ariane, primary, Garrigue-Antar, Laure, primary, Quintin-Colonna, Françoise, primary, Fridman, Wolf H., primary, Brasnu, Daniel, primary, Jacques, Yannick, primary, and Tartour, Eric, primary

Published
2023
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32. CXCR6 expressing T cells: Functions and role in the control of tumors

Author

Mabrouk, Nesrine, primary, Tran, Thi, additional, Sam, Ikuan, additional, Pourmir, Ivan, additional, Gruel, Nadège, additional, Granier, Clémence, additional, Pineau, Joséphine, additional, Gey, Alain, additional, Kobold, Sebastian, additional, Fabre, Elizabeth, additional, and Tartour, Eric, additional

Published
2022
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33. Plasma CD27, a Surrogate of the Intratumoral CD27–CD70 Interaction, Correlates with Immunotherapy Resistance in Renal Cell Carcinoma

Author

Benhamouda, Nadine, primary, Sam, Ikuan, additional, Epaillard, Nicolas, additional, Gey, Alain, additional, Phan, Letuan, additional, Pham, Hang Phuong, additional, Gruel, Nadège, additional, Saldmann, Antonin, additional, Pineau, Joséphine, additional, Hasan, Milena, additional, Quiniou, Valentin, additional, Nevoret, Camille, additional, Verkarre, Virginie, additional, Libri, Valentina, additional, Mella, Sebastien, additional, Granier, Clémence, additional, Broudin, Chloe, additional, Ravel, Patrice, additional, De Guillebon, Eléonore, additional, Mauge, Laetitia, additional, Helley, Dominique, additional, Jabla, Bernd, additional, Chaput, Nathalie, additional, Albiges, Laurence, additional, Katsahian, Sandrine, additional, Adam, Julien, additional, Mejean, Arnaud, additional, Adotevi, Olivier, additional, Vano, Yann A., additional, Oudard, Stéphane, additional, and Tartour, Eric, additional

Published
2022
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34. A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens

Author

Pere, Helene, Montier, Yves, Bayry, Jagadeesh, Quintin-Colonna, Francoise, Merillon, Nathalie, Dransart, Estelle, Badoual, Cecile, Gey, Alain, Ravel, Patrice, Marcheteau, Elie, Batteux, Frederic, Sandoval, Federico, Adotevi, Olivier, Chiu, Christopher, Garcia, Sylvie, Tanchot, Corinne, Lone, Yu-Chun, Ferreira, Luis Carlos, Nelson, Brad H., Hanahan, Douglas, Fridman, Wolf Herman, Johannes, Ludger, and Tartour, Eric

Published
2011
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35. Decrease of Pro-Angiogenic Monocytes Predicts Clinical Response to Anti-Angiogenic Treatment in Patients with Metastatic Renal Cell Carcinoma

Author

Oudard, Stephane, primary, Benhamouda, Nadine, additional, Escudier, Bernard, additional, Ravel, Patrice, additional, Tran, Thi, additional, Levionnois, Emeline, additional, Negrier, Sylvie, additional, Barthelemy, Philippe, additional, Berdah, Jean, additional, Gross-Goupil, Marine, additional, Sternberg, Cora, additional, Bono, Petri, additional, Porta, Camillo, additional, De Giorgi, Ugo, additional, Parikh, Omi, additional, Hawkins, Robert, additional, Highley, Martin, additional, Wilke, Jochen, additional, Decker, Thomas, additional, Tanchot, Corinne, additional, Gey, Alain, additional, Terme, Magali, additional, and Tartour, Eric, additional

Published
2021
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39. Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1(+) Tim-3(+) CD8(+) T Cells

Author

Granier, Clémence, Vinatier, Emeline, Colin, Elia, Mandavit, Marion, Dariane, Charles, Verkarre, Virginie, Biard, Lucie, El Zein, Rami, Lesaffre, Corinne, Galy-Fauroux, Isabelle, Roussel, Hélène, De Guillebon, Eléonore, Blanc, Charlotte, Saldmann, Antonin, Badoual, Cécile, Gey, Alain, and Tartour, Éric

Subjects
Male, Cancer Research, Programmed Cell Death 1 Receptor, Tumor Microenvironment, Fluorescent Antibody Technique, Humans, Female, CD8-Positive T-Lymphocytes, Carcinoma, Renal Cell, Retrospective Studies
Abstract

Immune cells are important components of the tumor microenvironment and influence tumor growth and evolution at all stages of carcinogenesis. Notably, it is now well established that the immune infiltrate in human tumors can correlate with prognosis and response to therapy. The analysis of the immune infiltrate in the tumor microenvironment has become a major challenge for the classification of patients and the response to treatment. The co-expression of inhibitory receptors such as Program Cell Death Protein 1 (PD1; also known as CD279), Cytotoxic T Lymphocyte Associated Protein 4 (CTLA-4), T-Cell Immunoglobulin and Mucin Containing Protein-3 (Tim-3; also known as CD366), and Lymphocyte Activation Gene 3 (Lag-3; also known as CD223), is a hallmark of T cell exhaustion. We developed a multiparametric in situ immunofluorescence staining to identify and quantify at the cellular level the co-expression of these inhibitory receptors. On a retrospective series of frozen tissue of renal cell carcinomas (RCC), using a fluorescence multispectral imaging technology coupled with an image analysis software, it was found that co-expression of PD-1 and Tim-3 on tumor infiltrating CD8(+) T cells is correlated with a poor prognosis in RCC. To our knowledge, this represents the first study demonstrating that this automated multiplex in situ technology may have some clinical relevance.

Published
2018

40. TIM-3 Dictates Functional Orientation of the Immune Infiltrate in Ovarian Cancer

Author

Fucikova, Jitka, primary, Rakova, Jana, additional, Hensler, Michal, additional, Kasikova, Lenka, additional, Belicova, Lucie, additional, Hladikova, Kamila, additional, Truxova, Iva, additional, Skapa, Petr, additional, Laco, Jan, additional, Pecen, Ladislav, additional, Praznovec, Ivan, additional, Halaska, Michael J., additional, Brtnicky, Tomas, additional, Kodet, Roman, additional, Fialova, Anna, additional, Pineau, Josephine, additional, Gey, Alain, additional, Tartour, Eric, additional, Ryska, Ales, additional, Galluzzi, Lorenzo, additional, and Spisek, Radek, additional

Published
2019
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41. High Therapeutic Efficacy of a New Survivin LSP-Cancer Vaccine Containing CD4+ and CD8+ T-Cell Epitopes

Author

Onodi, Fanny, primary, Maherzi-Mechalikh, Chahrazed, additional, Mougel, Alice, additional, Ben Hamouda, Nadine, additional, Taboas, Charlotte, additional, Gueugnon, Fabien, additional, Tran, Thi, additional, Nozach, Herve, additional, Marcon, Elodie, additional, Gey, Alain, additional, Terme, Magali, additional, Bouzidi, Ahmed, additional, Maillere, Bernard, additional, Kerzerho, Jérôme, additional, Tartour, Eric, additional, and Tanchot, Corinne, additional

Published
2018
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44. Prognostic value of intratumoral interferon gamma messenger RNA expression in invasive cervical carcinomas

Author

Tartour, Eric, Gey, Alain, Sastre-Garau, Xavier, Surin, Isabelle Lombard, Mosseri, Veronique, and Fridman, Wolf H.

Subjects
Cervical cancer -- Genetic aspects, Interferon gamma -- Research, Messenger RNA -- Measurement, Health
Abstract

Background: The production of the cytokine interferon gamma (IFN [Gamma]) by activated peripheral blood mononuclear cells may be reduced in patients with invasive cervical carcinoma. This study was designed to assess the prognostic value of intratumoral IFN [Gamma] messenger RNA (mRNA) levels in such patients. Methods: Biopsy specimens of primary cervical lesions were obtained from 27 patients with invasive squamous cell carcinoma before they received any therapy. Two prognostic groups were considered: 1) a group of 14 patients who had no apparent disease recurrence and who were alive 2 years after diagnosis (good-prognosis group) and 2) a group of 13 patients who had disease recurrence or died during the 2-year follow-up (poor-prognosis group). A competitive reverse transcription-polymerase chain reaction assay was used to measure levels of IFN [Gamma] and [Beta] actin mRNA. The expression of human leukocyte antigen (HLA) class II proteins (which is stimulated by IFN [Gamma]) in tumor cells was studied by immunostaining. Results: Tumor specimens from all 14 patients in the good-prognosis group contained more than [10.sup.3] IFN [Gamma] mRNA copies per 5 x [10.sup.5] [Beta] actin mRNA copies, whereas tumor specimens from only six of the 13 patients in the poor-prognosis group contained this level of IFN [Gamma] mRNA (two-sided P = .006). No clear relationship was observed between levels of IFN [Gamma] mRNA and T-cell or natural killer cell infiltration in tumors; however, a statistically significant association was observed between HLA class II expression on tumor cells and IFN [Gamma] mRNA levels (two-sided P = .01). Conclusions: A subgroup of poor-prognosis cervical carcinoma patients who have low levels of intratumoral IFN [Gamma] mRNA was identified. [J Natl Cancer Inst 1998; 90:287-94]

Published
1998

45. Tim-3

Author

Granier, Clémence, primary, Gey, Alain, additional, Dariane, Charles, additional, Mejean, Arnaud, additional, Timsit, Marc-Olivier, additional, Blanc, Charlotte, additional, Verkarre, Virginie, additional, Radulescu, Camélia, additional, Fabre, Elisabeth, additional, Vano, Yann, additional, Oudard, Stéphane, additional, Badoual, Cécile, additional, and Tartour, Éric, additional

Published
2018
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46. Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Author

Granier, Clémence, primary, Vinatier, Emeline, additional, Colin, Elia, additional, Mandavit, Marion, additional, Dariane, Charles, additional, Verkarre, Virginie, additional, Biard, Lucie, additional, El Zein, Rami, additional, Lesaffre, Corinne, additional, Galy-Fauroux, Isabelle, additional, Roussel, Hélène, additional, De Guillebon, Eléonore, additional, Blanc, Charlotte, additional, Saldmann, Antonin, additional, Badoual, Cécile, additional, Gey, Alain, additional, and Tartour, Éric, additional

Published
2018
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47. Tim-3 Expression on Tumor-Infiltrating PD-1+CD8+ T Cells Correlates with Poor Clinical Outcome in Renal Cell Carcinoma

Author

Granier, Clémence, primary, Dariane, Charles, additional, Combe, Pierre, additional, Verkarre, Virginie, additional, Urien, Saïk, additional, Badoual, Cécile, additional, Roussel, Hélène, additional, Mandavit, Marion, additional, Ravel, Patrice, additional, Sibony, Mathilde, additional, Biard, Lucie, additional, Radulescu, Camélia, additional, Vinatier, Emeline, additional, Benhamouda, Nadine, additional, Peyromaure, Michael, additional, Oudard, Stéphane, additional, Méjean, Arnaud, additional, Timsit, Marc-Olivier, additional, Gey, Alain, additional, and Tartour, Eric, additional

Published
2017
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48. Composite biomarkers defined by multiparametric immunofluorescence analysis identify ALK-positive adenocarcinoma as a potential target for immunotherapy

Author

Roussel, Hélène, primary, De Guillebon, Eléonore, additional, Biard, Lucie, additional, Mandavit, Marion, additional, Gibault, Laure, additional, Fabre, Elisabeth, additional, Antoine, Martine, additional, Hofman, Paul, additional, Beau-Faller, Michèle, additional, Blons, Hélène, additional, Danel, Claire, additional, Barthes, Françoise Le Pimpec, additional, Gey, Alain, additional, Granier, Clémence, additional, Wislez, Marie, additional, Laurent-Puig, Pierre, additional, Oudard, Stéphane, additional, Bruneval, Patrick, additional, Badoual, Cécile, additional, Cadranel, Jacques, additional, and Tartour, Eric, additional

Published
2017
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49. High Therapeutic Efficacy of a New Survivin LSP-Cancer Vaccine Containing CD4+ and CD8+ T-Cell Epitopes.

Author

Onodi, Fanny, Maherzi-Mechalikh, Chahrazed, Mougel, Alice, Ben Hamouda, Nadine, Taboas, Charlotte, Gueugnon, Fabien, Tran, Thi, Nozach, Herve, Marcon, Elodie, Gey, Alain, Terme, Magali, Bouzidi, Ahmed, Maillere, Bernard, Kerzerho, Jérôme, Tartour, Eric, and Tanchot, Corinne

Abstract

The efficacy of an antitumoral vaccine relies both on the choice of the antigen targeted and on its design. The tumor antigen survivin is an attractive target to develop therapeutic cancer vaccines because of its restricted over-expression and vital functions in most human tumors. Accordingly, several clinical trials targeting survivin in various cancer indications have been conducted. Most of them relied on short peptide-based vaccines and showed promising, but limited clinical results. In this study, we investigated the immunogenicity and therapeutic efficacy of a new long synthetic peptide (LSP)-based cancer vaccine targeting the tumor antigen survivin (SVX). This SVX vaccine is composed of three long synthetic peptides containing several CD4+ and CD8+ T-cell epitopes, which bind to various HLA class II and class I molecules. Studies in healthy individuals showed CD4+ and CD8+ T-cell immunogenicity of SVX peptides in human, irrespective of the individual's HLA types. Importantly, high frequencies of spontaneous T-cell precursors specific to SVX peptides were also detected in the blood of various cancer patients, demonstrating the absence of tolerance against these peptides. We then demonstrated SVX vaccine's high therapeutic efficacy against four different established murine tumor models, associated with its capacity to generate both specific cytotoxic CD8+ and multifunctional Th1 CD4+ T-cell responses. When tumors were eradicated, generated memory T-cell responses protected against rechallenge allowing long-term protection against relapses. Treatment with SVX vaccine was also found to reshape the tumor microenvironment by increasing the tumor infiltration of both CD4+ and CD8+ T cells but not Treg cells therefore tipping the balance toward a highly efficient immune response. These results highlight that this LSP-based SVX vaccine appears as a promising cancer vaccine and warrants its further clinical development. [ABSTRACT FROM AUTHOR]

Published
2018
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50. A Therapeutic Her2/neu Vaccine Targeting Dendritic Cells Preferentially Inhibits the Growth of Low Her2/neu–Expressing Tumor in HLA-A2 Transgenic Mice

Author

Tran, Thi, primary, Diniz, Mariana O., additional, Dransart, Estelle, additional, Gey, Alain, additional, Merillon, Nathalie, additional, Lone, Yu Chun, additional, Godefroy, Sylvie, additional, Sibley, Craig, additional, Ferreira, Luis CS, additional, Medioni, Jacques, additional, Oudard, Stephane, additional, Johannes, Ludger, additional, and Tartour, Eric, additional

Published
2016
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