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150 results on '"Gess B"'

1. Lyapunov exponents and synchronisation by noise for systems of SPDEs

Author

Gess, B. and Tsatsoulis, P.

Subjects
Mathematics - Probability, Mathematics - Analysis of PDEs, Mathematics - Dynamical Systems, 60H15, 37H15, 37L30, 35K57
Abstract

Quantitative estimates for the top Lyapunov exponents for systems of stochastic reaction-diffusion equations are proven. The treatment includes reaction potentials with degenerate minima. The proof relies on an asymptotic expansion of the invariant measure, with careful control on the resulting error terms. As a consequence of these estimates, synchronisation by noise is deduced for systems of stochastic reaction-diffusion equations for the first time.

Published
2022

2. Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin

Author

Hucke, A, Schröter, R, Ceresa, C, Chiorazzi, A, Canta, A, Semperboni, S, Marmiroli, P, Cavaletti, G, Gess, B, Ciarimboli, G, Hucke A., Schröter R., Ceresa C., Chiorazzi A., Canta A., Semperboni S., Marmiroli P., Cavaletti G., Gess B., Ciarimboli G., Hucke, A, Schröter, R, Ceresa, C, Chiorazzi, A, Canta, A, Semperboni, S, Marmiroli, P, Cavaletti, G, Gess, B, Ciarimboli, G, Hucke A., Schröter R., Ceresa C., Chiorazzi A., Canta A., Semperboni S., Marmiroli P., Cavaletti G., Gess B., and Ciarimboli G.

Abstract

Cisplatin (CDDP) is an efficient chemotherapeutic agent broadly used to treat solid cancers. Chemotherapy with CDDP can cause significant unwanted side effects such as renal toxicity and peripheral neurotoxicity. CDDP is a substrate of organic cation transporters (OCT), transporters that are highly expressed in renal tissue. Therefore, CDDP uptake by OCT may play a role in causing unwanted toxicities of CDDP anticancer treatment. In this study, the contribution of the mouse OCT2 (mOCT2) to CDDP nephro- and peripheral neurotoxicity was investigated by comparing the effects of cyclic treatment with low doses of CDDP on renal and neurological functions in wild-type (WT) mice and mice with genetic deletion of OCT2 (OCT2−/− mice). This CDDP treatment protocol caused significant impairment of kidneys and peripherical neurological functions in WT mice. These effects were significantly reduced in OCT2−/− mice, however, less profoundly than what was previously measured in mice with genetic deletion of both OCT1 and 2 (OCT1-2−/− mice). Comparing the apparent affinities (IC50) of mOCT1 and mOCT2 for CDDP, the mOCT1 displayed a higher affinity for CDDP than the mOCT2 (IC50: 9 and 558 µM, respectively). Also, cellular toxicity induced by incubation with 100 µM CDDP was more pronounced in cells stably expressing mOCT1 than in cells expressing mOCT2. Therefore, in mice, CDDP uptake by both OCT1 and 2 contributes to the development of CDDP undesired side effects. OCT seem to be suitable targets for establishing treatment protocols aimed at decreasing unwanted CDDP toxicity and improving anticancer treatment with CDDP.

Published
2023

4. The global random attractor for a class of stochastic porous media equations

Author

Beyn, W., Gess, B., Lescot, P., and Röckner, M.

Subjects
Mathematics - Probability, Primary: 76S05, 60H15, Secondary: 37L55, 35B41
Abstract

We prove new $L^2$-estimates and regularity results for generalized porous media equations "shifted by" a function-valued Wiener path. To include Wiener paths with merely first spatial (weak) derivates we introduce the notion of "$\zeta$-monotonicity" for the non-linear function in the equation. As a consequence we prove that stochastic porous media equations have global random attractors. In addition, we show that (in particular for the classical stochastic porous media equation) this attractor consists of a random point.

Published
2010

6. Sex Differences in Wild-Type Transthyretin Amyloidosis: An Analysis from the Transthyretin Amyloidosis Outcomes Survey (THAOS)

Author

Campbell, C. M., Lorusso, S., Dispenzieri, A., Kristen, A. V., Maurer, M. S., Rapezzi, C., Lairez, O., Drachman, B., Garcia-Pavia, P., Grogan, M., Chapman, D., Amass, L., Emdin, M., Hanna, M., Azevedo, O., Cirami, C. L., Jacoby, D., Costello, J. G., Slosky, D., Moelgaard, H., Hummel, S., Nativi-Nicolau, J., Murali, S., Fine, N., Jeon, E. -S., Shah, S., Witteles, R., Lenihan, D., Waddington-Cruz, M., Sekijima, Y., Tallaj, J., Mueller, C., Van Cleemput, J., Plante-Bordeneuve, V., Nienhuis, H., Quan, D., Steidley, D., Schmidt, H., Wixner, J., Polydefkis, M., Ralph, J., Ventura, H., Zivkovic, S., Gess, B., Torron, R. F., Gottlieb, S., Cotts, W., Tauras, J., Sarswat, N., Moreno, J. G., Parman, Y., and Luo, J.

Subjects
Registry, Sex, Transthyretin Amyloidosis Outcomes Survey, ATTRwt amyloidosis, Cardiology and Cardiovascular Medicine
Abstract

Wild-type transthyretin amyloidosis (ATTRwt amyloidosis) is a progressive disease resulting from the accumulation of wild-type transthyretin (TTR) amyloid fibrils, and is diagnosed primarily in males. This analysis examined sex differences in patients with ATTRwt amyloidosis from the Transthyretin Amyloidosis Outcomes Survey (THAOS).THAOS is an ongoing, global, longitudinal, observational survey of patients with transthyretin amyloidosis, including both inherited and wild-type disease, and asymptomatic carriers of TTR mutations. THAOS data were analyzed to identify potential differences in demographic and clinical characteristics between males and females with ATTRwt amyloidosis (data cutoff: August 1, 2021).Of 1386 patients with ATTRwt amyloidosis, 84 (6%) were female and 1302 (94%) were male. Females had a higher median age at enrollment (80 vs. 78 years; p = 0.002) and symptom onset (75 vs. 73 years; p = 0.045) than males. Mean left ventricular (LV) ejection fraction was higher (53% vs. 48%; p = 0.001) and mean LV diastolic diameter lower (42 vs. 46 mm; p 0.001) in females versus males, but sex was not identified as a predictor of LV mean wall thickness adjusted for height (beta coefficient - 0.22; p = 0.460) or a predominantly cardiac phenotype (odds ratio 1.60; p = 0.191). Modified polyneuropathy disability scores differed between groups (p 0.001), with a larger proportion of scores ≥ IIIa among females (23% vs. 7%).Females with ATTRwt amyloidosis in THAOS tended to present at a later age and showed signs of less severe cardiac impairment and more severe walking impairment.ClinicalTrials.gov: NCT00628745.

Published
2022

24. Wertigkeit des ONLS (Overall Neuropathy Limitations Scale) als klinischer Parameter bei der Charcot-Marie-Tooth (CMT) Erkrankung

Author

Akova-Öztürk, E, additional, Dräger, B, additional, Schlotter-Weigel, B, additional, Thiele, S, additional, Garcia-Angarita, N, additional, Greckl, E, additional, Reinecke, L, additional, Prukop, T, additional, Fritzsch, S, additional, Dohrn, MF, additional, Gess, B, additional, Sereda, MW, additional, Walter, MC, additional, and Young, P, additional

Published
2019
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