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3. Incidence and Clearance of Anal Human Papillomavirus Infection in 16 164 Individuals, According to Human Immunodeficiency Virus Status, Sex, and Male Sexuality: An International Pooled Analysis of 34 Longitudinal Studies.

Author

Wei, Feixue, Goodman, Marc T, Xia, Ningshao, Zhang, Jun, Giuliano, Anna R, D'Souza, Gypsyamber, Hessol, Nancy A, Schim van der Loeff, Maarten F, Dai, Jianghong, Neukam, Karin, de Pokomandy, Alexandra, Poynten, I Mary, Geskus, Ronald B, Burgos, Joaquin, Etienney, Isabelle, Moscicki, Anna-Barbara, Donà, Maria Gabriella, Gillison, Maura L, Nyitray, Alan G, Nowak, Rebecca G, Yunihastuti, Evy, Zou, Huachun, Hidalgo-Tenorio, Carmen, Phanuphak, Nittaya, Molina, Jean-Michel, Schofield, Alice M, Kerr, Stephen, Fan, Song, Lu, Yong, Ong, Jason J, Chikandiwa, Admire T, Teeraananchai, Sirinya, Squillace, Nicola, Wiley, Dorothy J, Palefsky, Joel M, Georges, Damien, Alberts, Catharina J, and Clifford, Gary M

Subjects
Cancer, Infectious Diseases, Behavioral and Social Science, Sexually Transmitted Infections, Clinical Research, Sexual and Gender Minorities (SGM/LGBT*), Prevention, HIV/AIDS, Aetiology, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Male, Humans, Female, Homosexuality, Male, Human Papillomavirus Viruses, Papillomavirus Infections, HIV Infections, Incidence, Sexual and Gender Minorities, Sexual Behavior, Anal Canal, Anus Diseases, Longitudinal Studies, Anus Neoplasms, Human papillomavirus 16, HIV, Papillomaviridae, HPV, anus, incidence, clearance, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

BackgroundUnderstanding the natural history of anal high-risk human papillomavirus (hrHPV) infection is key for designing anal cancer prevention programs but has not been systematically characterized.MethodsWe reanalyzed data from 34 studies including 16 164 individuals in 6 risk groups defined by human immunodeficiency virus (HIV) status, sex, and male sexuality: men who have sex with men (MSM) and people with HIV (MSMWH), HIV-negative MSM, women with HIV (WWH), HIV-negative women, men who have sex with women (MSW) with HIV (MSWWH), and HIV-negative MSW. We used Markov models to estimate incidence and clearance of 13 hrHPV types and their determinants.ResultsHuman papillomavirus (HPV) 16 had the highest incidence-clearance ratio of the hrHPV types. MSMWH had the highest hrHPV incidence (eg, 15.5% newly HPV-16 infected within 2 years), followed by HIV-negative MSM (7.5%), WWH (6.6%), HIV-negative women (2.9%), MSWWH (1.7%), and HIV-negative MSW (0.7%). Determinants of HPV-16 incidence included HIV status and number of sexual partners for MSM, women, and MSW, and anal sex behavior for MSM only. HPV-16 clearance was lower for people with HIV (PWH) and lower for prevalent than incident infection. Among MSM, increasing age was associated with lower clearance of prevalent, but not incident, HPV-16 infection.ConclusionsThis robust and unifying analysis of anal hrHPV natural history is essential to designing and predicting the impact of HPV vaccination and HPV-based screening programs on anal cancer prevention, particularly in MSM and PWH. Importantly, it demonstrates the higher carcinogenic potential of longstanding anal prevalent hrHPV infection than more recent incident infection.

Published
2023

4. Urinary catecholamine excretion, cardiovascular variability, and outcomes in tetanus

Author

Du, Duc Hong, Hao, Nguyen Quan Nhu, Van Hao, Nguyen, Thanh, Tran Tan, Loan, Huynh Thi, Yen, Lam Minh, Thuy, Tran Thi Diem, Thuy, Duong Bich, Nguyen, Nguyen Thanh, Dung, Nguyen Thi Phuong, Kestelyn, Evelyne, Duong, Ha Thi Hai, Phong, Nguyen Thanh, Tuyen, Pham Thi, Phu, Nguyen Hoan, Nghia, Ho Dang Trung, Hanh, Bui Thi Bich, Oanh, Pham Kieu Nguyet, Tho, Phan Vinh, Nhat, Phung Tran Huy, Khanh, Phan Nguyen Quoc, Wyncoll, Duncan, Day, Nicholas P. J., Van Vinh Chau, Nguyen, van Doorn, H. Rogier, Van Tan, Le, Geskus, Ronald B., and Thwaites, C. Louise

Published
2023
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5. Early diagnostic indicators of dengue versus other febrile illnesses in Asia and Latin America (IDAMS study): a multicentre, prospective, observational study

Author

Hasan, Zabir, Wanderley Lopes Gomes, Kilma, Soares Mesquita, Lyvia Patricia, Braga, Cynthia, Castanha, Priscila M.S., Cordeiro, Marli T., Damasceno, Luana, Chuop, Bophal, Ouk, Sonyrath, Sin, Reaksmey, Sun, Sopheary, Alvarez Vera, Mayling, Barahona, Guillermo, Cruz, Bladimir, Beck, Dorothea, Gaczkowski, Roger, Junghanss, Thomas, Morales, Ivonne, Wirths, Marius, Natkunam, Santha Kumari, Ho, Bee Kiau, AbuBakar, Sazaly, Abd-Jamil, Juraina, Syed Omar, Sharifah Faridah, Lizarazo, Erley F., Vincenti-González, María F., Tovar, Robert, Cao Thi, Tam, Dinh Thi Tri, Hong, Huynh Le Anh, Huy, Huynh Thi Le, Duyen, Lai Thi Cong, Thanh, Nguyen Thi Hong, Van, Nguyen Thi My, Linh, Tran Thi Nhu, Thuy, Truong Thi Thu, Thuy, Banh Thi, Nuoi, Huynh Lam Thuy, Trinh, Nguyen Thi Thu, Hiep, Tran Thi Kim, Van, Vo Thanh, Luan, Dang Thi, Bich, Dinh Thi Thu, Huong, Dinh Van, Huy, Nguyen Nguyen, Huyen, Vu Thi Thu, Huong, Rosenberger, Kerstin D, Phung Khanh, Lam, Tobian, Frank, Chanpheaktra, Ngoun, Kumar, Varun, Lum, Lucy Chai See, Sathar, Jameela, Pleités Sandoval, Ernesto, Marón, Gabriela M, Laksono, Ida Safitri, Mahendradhata, Yodi, Sarker, Malabika, Rahman, Ridwanur, Caprara, Andrea, Souza Benevides, Bruno, Marques, Ernesto T A, Magalhaes, Tereza, Brasil, Patrícia, Amaral Calvet, Guilherme, Tami, Adriana, Bethencourt, Sarah E, Dong Thi Hoai, Tam, Nguyen Tan Thanh, Kieu, Tran Van, Ngoc, Nguyen Tran, Nam, Do Chau, Viet, Yacoub, Sophie, Nguyen Van, Kinh, Guzmán, María G, Martinez, Pedro A, Nguyen Than Ha, Quyen, Simmons, Cameron P, Wills, Bridget A, Geskus, Ronald B, and Jaenisch, Thomas

Published
2023
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6. Dengue Viremia Kinetics and Effects on Platelet Count and Clinical Outcomes: An Analysis of 2340 Patients from Vietnam

Author

Vuong, Nguyen Lam, primary, Ha Quyen, Nguyen Than, additional, Hanh Tien, Nguyen Thi, additional, Hue Kien, Duong Thi, additional, Le Duyen, Huynh Thi, additional, Lam, Phung Khanh, additional, Hoai Tam, Dong Thi, additional, Ngoc, Tran Van, additional, Jaenisch, Thomas, additional, Simmons, Cameron P., additional, Yacoub, Sophie, additional, Wills, Bridget A., additional, and Geskus, Ronald B., additional

Published
2024
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7. Author response: Dengue Viremia Kinetics and Effects on Platelet Count and Clinical Outcomes: An Analysis of 2340 Patients from Vietnam

Author

Vuong, Nguyen Lam, primary, Ha Quyen, Nguyen Than, additional, Hanh Tien, Nguyen Thi, additional, Hue Kien, Duong Thi, additional, Le Duyen, Huynh Thi, additional, Lam, Phung Khanh, additional, Hoai Tam, Dong Thi, additional, Ngoc, Tran Van, additional, Jaenisch, Thomas, additional, Simmons, Cameron P., additional, Yacoub, Sophie, additional, Wills, Bridget A., additional, and Geskus, Ronald B., additional

Published
2024
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8. Metformin as adjunctive therapy in combination with multidrug treatment for multibacillary leprosy: A protocol for a randomized double-blind, controlled Phase 2 trial in Indonesia (MetLep Trial)

Author

Krismawati, Hana, primary, Muchtar, Sri V., additional, Rahardjani, Mutia, additional, Utami, Nindya N., additional, Oktaviani, Margareta, additional, Puspatriani, Khairunnisa, additional, ., Syamsiah, additional, Imbiri, Nelly, additional, Hasvitasari, Dian E., additional, Fajrianti, Dwi R., additional, Tarino, Nico, additional, Wulandari, Fitri, additional, Kestelyn, Evelyne, additional, Du, Duc H., additional, van Crevel, Reinout, additional, Walker, Stephen L., additional, Geskus, Ronald B., additional, Geluk, Annemieke, additional, Hamers, Raph L., additional, Soebono, Hardyanto, additional, and Grijsen, Marlous L., additional

Published
2024
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9. Risk of Parkinson's disease dementia related to level I MDS PD‐MCI

Author

Hoogland, Jeroen, Boel, Judith A, Bie, Rob MA, Schmand, Ben A, Geskus, Ronald B, Dalrymple‐Alford, John C, Marras, Connie, Adler, Charles H, Weintraub, Daniel, Junque, Carmen, Pedersen, Kenn F, Mollenhauer, Brit, Goldman, Jennifer G, Tröster, Alexander I, Burn, David J, Litvan, Irene, Geurtsen, Gert J, and Disease”, on behalf of the MDS Study Group Validation of Mild Cognitive Impairment in Parkinson

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Aging, Prevention, Acquired Cognitive Impairment, Dementia, Behavioral and Social Science, Clinical Research, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Parkinson's Disease, Alzheimer's Disease, Neurodegenerative, Neurological, Age Factors, Aged, Cognitive Dysfunction, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease, Risk Factors, Sex Factors, dementia, mild cognitive impairment, neuropsychological tests, Parkinson's disease, survival analysis, MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”, Human Movement and Sports Sciences, Neurology & Neurosurgery, Clinical sciences
Abstract

BackgroundThe International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria.MethodsWe analyzed data from 8 international studies (1045 patients) from our consortium that included baseline data on demographics, motor signs, depression, detailed neuropsychological testing, and longitudinal follow-up for conversion to Parkinson's disease dementia. Survival analysis evaluated their contribution to the hazard of Parkinson's disease dementia.ResultsLevel I mild cognitive impairment in PD, increasing age, male sex, and severity of PD motor signs independently increased the hazard of Parkinson's disease dementia. Level I and level II mild cognitive impairment in PD classification had similar discriminative ability with respect to the time to Parkinson's disease dementia.ConclusionsLevel I mild cognitive impairment in PD classification independently contributes to the hazard of Parkinson's disease dementia. This finding supports the prognostic validity of the abbreviated mild cognitive impairment in PD criteria. © 2019 International Parkinson and Movement Disorder Society.

Published
2019

11. Human versus equine intramuscular antitoxin, with or without human intrathecal antitoxin, for the treatment of adults with tetanus: a 2 × 2 factorial randomised controlled trial

Author

Van Hao, Nguyen, Loan, Huynh Thi, Yen, Lam Minh, Kestelyn, Evelyne, Hong, Duc Du, Thuy, Duong Bich, Nguyen, Nguyen Thanh, Duong, Ha Thi Hai, Thuy, Tran Thi Diem, Nhat, Phung Tran Huy, Khanh, Phan Nguyen Quoc, Dung, Nguyen Thi Phuong, Phu, Nguyen Hoan, Phong, Nguyen Thanh, Lieu, Pham Thi, Tuyen, Pham Thi, Hanh, Bui Thi Bich, Nghia, Ho Dang Trung, Oanh, Pham Kieu Nguyet, Tho, Phan Vinh, Tan Thanh, Tran, Turner, Hugo C, van Doorn, H Rogier, Van Tan, Le, Wyncoll, Duncan, Day, Nicholas PJ, Geskus, Ronald B, Thwaites, Guy E, Van Vinh Chau, Nguyen, and Thwaites, C Louise

Published
2022
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12. Mild cognitive impairment as a risk factor for Parkinson's disease dementia

Author

Hoogland, Jeroen, Boel, Judith A, Bie, Rob MA, Geskus, Ronald B, Schmand, Ben A, Dalrymple‐Alford, John C, Marras, Connie, Adler, Charles H, Goldman, Jennifer G, Tröster, Alexander I, Burn, David J, Litvan, Irene, Geurtsen, Gert J, and Disease”, on behalf of the MDS Study Group Validation of Mild Cognitive Impairment in Parkinson

Subjects
Aging, Behavioral and Social Science, Parkinson's Disease, Neurosciences, Rehabilitation, Neurodegenerative, Brain Disorders, Acquired Cognitive Impairment, Clinical Research, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease, Dementia, 2.1 Biological and endogenous factors, Aetiology, Neurological, Adult, Aged, Aged, 80 and over, Cognitive Dysfunction, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Parkinson Disease, Risk Factors, Severity of Illness Index, Parkinson's disease, mild cognitive impairment, dementia, neuropsychological tests, survival analyses, MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”, Clinical Sciences, Human Movement and Sports Sciences, Neurology & Neurosurgery
Abstract

BackgroundThe International Parkinson and Movement Disorder Society criteria for mild cognitive impairment in PD were recently formulated.ObjectivesThe aim of this international study was to evaluate the predictive validity of the comprehensive (level II) version of these criteria by assessment of their contribution to the hazard of PD dementia.MethodsIndividual patient data were selected from four separate studies on cognition in PD that provided information on demographics, motor examination, depression, neuropsychological examination suitable for application of level II criteria, and longitudinal follow-up for conversion to dementia. Survival analysis evaluated the predictive value of level II criteria for cognitive decline toward dementia as expressed by the relative hazard of dementia.ResultsA total of 467 patients were included. The analyses showed a clear contribution of impairment according to level II mild cognitive impairment criteria, age, and severity of PD motor symptoms to the hazard of dementia. There was a trend of increasing hazard of dementia with declining neuropsychological performance.ConclusionsThis is the first large international study evaluating the predictive validity of level II mild cognitive impairment criteria for PD. The results showed a clear and unique contribution of classification according to level II criteria to the hazard of PD dementia. This finding supports their predictive validity and shows that they contribute important new information on the hazard of dementia, beyond known demographic and PD-specific factors of influence. © 2017 International Parkinson and Movement Disorder Society.

Published
2017

13. Xpert MTB/RIF Ultra versus Xpert MTB/RIF for the diagnosis of tuberculous meningitis: a prospective, randomised, diagnostic accuracy study

Author

Donovan, Joseph, Thu, Do Dang Anh, Phu, Nguyen Hoan, Dung, Vu Thi Mong, Quang, Tran Phu, Nghia, Ho Dang Trung, Oanh, Pham Kieu Nguyet, Nhu, Tran Bao, Chau, Nguyen Van Vinh, Ha, Vu Thi Ngoc, Hang, Vu Thi Ty, Trinh, Dong Huu Khanh, Geskus, Ronald B, Tan, Le Van, Thuong, Nguyen Thuy Thuong, and Thwaites, Guy E

Published
2020
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14. The effect of M. tuberculosis lineage on clinical phenotype

Author

Du, Duc Hong, primary, Geskus, Ronald B., additional, Zhao, Yanlin, additional, Codecasa, Luigi Ruffo, additional, Cirillo, Daniela Maria, additional, van Crevel, Reinout, additional, Pascapurnama, Dyshelly Nurkartika, additional, Chaidir, Lidya, additional, Niemann, Stefan, additional, Diel, Roland, additional, Omar, Shaheed Vally, additional, Grandjean, Louis, additional, Rokadiya, Sakib, additional, Ortitz, Arturo Torres, additional, Lân, Nguyễn Hữu, additional, Hà, Đặng Thị Minh, additional, Smith, E. Grace, additional, Robinson, Esther, additional, Dedicoat, Martin, additional, Nhat, Le Thanh Hoang, additional, Thwaites, Guy E., additional, Van, Le Hong, additional, Thuong, Nguyen Thuy Thuong, additional, and Walker, Timothy M., additional

Published
2023
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16. Adjunctive Dexamethasone for Tuberculous Meningitis in HIV-Positive Adults

Author

Donovan, Joseph, primary, Bang, Nguyen D., additional, Imran, Darma, additional, Nghia, Ho D.T., additional, Burhan, Erlina, additional, Huong, Dau T.T., additional, Hiep, Nguyen T.T., additional, Ngoc, Lam H.B., additional, Thanh, Dang V., additional, Thanh, Nguyen T., additional, Wardhani, Anna L.S., additional, Maharani, Kartika, additional, Gasmara, Cakra P., additional, Hanh, Nguyen H.H., additional, Oanh, Pham K.N., additional, Estiasari, Riwanti, additional, Thu, Do D.A., additional, Kusumaningrum, Ardiana, additional, Dung, Le T., additional, Giang, Do C., additional, Ha, Dang T.M., additional, Lan, Nguyen H., additional, Chau, Nguyen V.V., additional, Nguyet, Nguyen T.M., additional, Geskus, Ronald B., additional, Thuong, Nguyen T.T., additional, Kestelyn, Evelyne, additional, Hamers, Raph L., additional, Phu, Nguyen H., additional, and Thwaites, Guy E., additional

Published
2023
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19. Interferon lambda 3 genotype predicts hepatitis C virus RNA levels in early acute infection among people who inject drugs: The InC3 Study

Author

Hajarizadeh, Behzad, Grady, Bart, Page, Kimberly, Kim, Arthur Y, McGovern, Barbara H, Cox, Andrea L, Rice, Thomas M, Sacks-Davis, Rachel, Bruneau, Julie, Morris, Meghan, Amin, Janaki, Schinkel, Janke, Applegate, Tanya, Maher, Lisa, Hellard, Margaret, Lloyd, Andrew R, Prins, Maria, Geskus, Ronald B, Dore, Gregory J, Grebely, Jason, and Group, InC3Study

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, HIV/AIDS, Digestive Diseases, Hepatitis - C, Liver Disease, Chronic Liver Disease and Cirrhosis, Emerging Infectious Diseases, Infectious Diseases, Hepatitis, Clinical Research, Genetics, Infection, Good Health and Well Being, Adult, Cohort Studies, Female, Genotype, Hepacivirus, Hepatitis C, Humans, Interferons, Interleukins, Male, RNA, Viral, Substance Abuse, Intravenous, Viral Load, Young Adult, Viral load, Acute HCV, IFNL3 genotype, IL28B genotype, Cohort study, InC(3)Study Group, Microbiology, Clinical Sciences, Virology, Clinical sciences, Medical microbiology
Abstract

Background and objectivesHepatitis C virus (HCV) RNA level in acute HCV infection is predictive of spontaneous clearance. This study assessed factors associated with HCV RNA levels during early acute infection among people who inject drugs with well-defined acute HCV infection.Study designData were from International Collaboration of Incident HIV and Hepatitis C in Injecting Cohorts (InC(3)) Study, an international collaboration of nine prospective cohorts studying acute HCV infection. Individuals with available HCV RNA levels during early acute infection (first two months following infection) were included. The distribution of HCV RNA levels during early acute infection were compared by selected host and virological factors.ResultsA total of 195 individuals were included. Median HCV RNA levels were significantly higher among individuals with interferon lambda 3 (IFNL3, formerly called IL28B) CC genotype compared to those with TT/CT genotype (6.28 vs. 5.39logIU/mL, respectively; P=0.01). IFNL3 CC genotype was also associated with top tertile HCV RNA levels (≥6.3log IU/mL; vs. TT/CT genotype; adjusted Odds Ratio: 4.28; 95%CI: 2.01, 9.10; P

Published
2014

22. Prognostic Models for 9-Month Mortality in Tuberculous Meningitis

Author

Le Thi Phuong Thao, Heemskerk, A. Dorothee, Geskus, Ronald B., Mai, Nguyen Thi Hoang, Ha, Dang Thi Minh, Chau, Tran Thi Hong, Phu, Nguyen Hoan, Van Vinh Chau, Nguyen, Caws, Maxine, Lan, Nguyen Huu, Thu, Do Dang Anh, Thuong, Nguyen Thuy Thuong, Day, Jeremy, Farrar, Jeremy J., Torok, M. Estee, Bang, Nguyen Duc, Thwaites, Guy E., and Wolbers, Marcel

Published
2018

31. The effect of M. tuberculosis lineage on clinical phenotype: a retrospective observational study

Author

Walker, Timothy, primary, Du, Duc Hong, additional, Geskus, Ronald B, additional, Zhao, Yanlin, additional, Codecasa, Luigi Ruffo, additional, Cirillo, Daniela Maria, additional, van Crevel, Reinout, additional, Pascapurnama, Dyshelly Nurkartika, additional, Chaidir, Lidya, additional, Niemann, Stefan, additional, Diel, Roland, additional, Omar, Shaheed Vally, additional, Grandjean, Louis, additional, Rokadiya, Sakib, additional, Ortitz, Arturo Torres, additional, Lân, Nguyễn Hữu, additional, Hà, Đặng Thị Minh, additional, Smith, E. Grace, additional, Robinson, Esther, additional, Dedicoat, Martin, additional, Nhat, Le Thanh Hoang, additional, Thwaites, Guy E, additional, Van, Le Hong, additional, and Thuong, Nguyen Thuy Thuong, additional

Published
2023
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32. Early diagnostic indicators of dengue versus other febrile illnesses in Asia and Latin America (IDAMS study): a multicentre, prospective, observational study

Author

Rosenberger, Kerstin D, primary, Phung Khanh, Lam, additional, Tobian, Frank, additional, Chanpheaktra, Ngoun, additional, Kumar, Varun, additional, Lum, Lucy Chai See, additional, Sathar, Jameela, additional, Pleités Sandoval, Ernesto, additional, Marón, Gabriela M, additional, Laksono, Ida Safitri, additional, Mahendradhata, Yodi, additional, Sarker, Malabika, additional, Rahman, Ridwanur, additional, Caprara, Andrea, additional, Souza Benevides, Bruno, additional, Marques, Ernesto T A, additional, Magalhaes, Tereza, additional, Brasil, Patrícia, additional, Amaral Calvet, Guilherme, additional, Tami, Adriana, additional, Bethencourt, Sarah E, additional, Dong Thi Hoai, Tam, additional, Nguyen Tan Thanh, Kieu, additional, Tran Van, Ngoc, additional, Nguyen Tran, Nam, additional, Do Chau, Viet, additional, Yacoub, Sophie, additional, Nguyen Van, Kinh, additional, Guzmán, María G, additional, Martinez, Pedro A, additional, Nguyen Than Ha, Quyen, additional, Simmons, Cameron P, additional, Wills, Bridget A, additional, Geskus, Ronald B, additional, Jaenisch, Thomas, additional, Hasan, Zabir, additional, Wanderley Lopes Gomes, Kilma, additional, Soares Mesquita, Lyvia Patricia, additional, Braga, Cynthia, additional, Castanha, Priscila M.S., additional, Cordeiro, Marli T., additional, Damasceno, Luana, additional, Chuop, Bophal, additional, Ouk, Sonyrath, additional, Sin, Reaksmey, additional, Sun, Sopheary, additional, Alvarez Vera, Mayling, additional, Barahona, Guillermo, additional, Cruz, Bladimir, additional, Beck, Dorothea, additional, Gaczkowski, Roger, additional, Junghanss, Thomas, additional, Morales, Ivonne, additional, Wirths, Marius, additional, Natkunam, Santha Kumari, additional, Ho, Bee Kiau, additional, AbuBakar, Sazaly, additional, Abd-Jamil, Juraina, additional, Syed Omar, Sharifah Faridah, additional, Lizarazo, Erley F., additional, Vincenti-González, María F., additional, Tovar, Robert, additional, Cao Thi, Tam, additional, Dinh Thi Tri, Hong, additional, Huynh Le Anh, Huy, additional, Huynh Thi Le, Duyen, additional, Lai Thi Cong, Thanh, additional, Nguyen Thi Hong, Van, additional, Nguyen Thi My, Linh, additional, Tran Thi Nhu, Thuy, additional, Truong Thi Thu, Thuy, additional, Banh Thi, Nuoi, additional, Huynh Lam Thuy, Trinh, additional, Nguyen Thi Thu, Hiep, additional, Tran Thi Kim, Van, additional, Vo Thanh, Luan, additional, Dang Thi, Bich, additional, Dinh Thi Thu, Huong, additional, Dinh Van, Huy, additional, Nguyen Nguyen, Huyen, additional, and Vu Thi Thu, Huong, additional

Published
2023
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37. Incidence and Clearance of Anal Human Papillomavirus Infection in 16 164 Individuals, According to Human Immunodeficiency Virus Status, Sex, and Male Sexuality: An International Pooled Analysis of 34 Longitudinal Studies

Author

Wei, Feixue, primary, Goodman, Marc T, additional, Xia, Ningshao, additional, Zhang, Jun, additional, Giuliano, Anna R, additional, D’Souza, Gypsyamber, additional, Hessol, Nancy A, additional, Schim van der Loeff, Maarten F, additional, Dai, Jianghong, additional, Neukam, Karin, additional, de Pokomandy, Alexandra, additional, Poynten, I Mary, additional, Geskus, Ronald B, additional, Burgos, Joaquin, additional, Etienney, Isabelle, additional, Moscicki, Anna-Barbara, additional, Donà, Maria Gabriella, additional, Gillison, Maura L, additional, Nyitray, Alan G, additional, Nowak, Rebecca G, additional, Yunihastuti, Evy, additional, Zou, Huachun, additional, Hidalgo-Tenorio, Carmen, additional, Phanuphak, Nittaya, additional, Molina, Jean-Michel, additional, Schofield, Alice M, additional, Kerr, Stephen, additional, Fan, Song, additional, Lu, Yong, additional, Ong, Jason J, additional, Chikandiwa, Admire T, additional, Teeraananchai, Sirinya, additional, Squillace, Nicola, additional, Wiley, Dorothy J, additional, Palefsky, Joel M, additional, Georges, Damien, additional, Alberts, Catharina J, additional, and Clifford, Gary M, additional

Published
2022
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39. Continuous versus intermittent endotracheal cuff pressure control for the prevention of ventilator-associated respiratory infections in Vietnam: study protocol for a randomised controlled trial

Author

Dat, Vu Quoc, Geskus, Ronald B., Wolbers, Marcel, Loan, Huynh Thi, Yen, Lam Minh, Binh, Nguyen Thien, Chien, Le Thanh, Mai, Nguyen Thi Hoang, Phu, Nguyen Hoan, Lan, Nguyen Phu Huong, Hao, Nguyen Van, Long, Hoang Bao, Thuy, Tran Phuong, Kinh, Nguyen Van, Trung, Nguyen Vu, Phu, Vu Dinh, Cap, Nguyen Trung, Trinh, Dao Tuyet, Campbell, James, Kestelyn, Evelyne, Wertheim, Heiman F. L., Wyncoll, Duncan, Thwaites, Guy Edward, van Doorn, H. Rogier, Thwaites, C. Louise, and Nadjm, Behzad

Published
2018
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40. Antimicrobial resistance in commensal Escherichia coli from humans and chickens in the Mekong Delta of Vietnam is driven by antimicrobial usage and potential cross-species transmission

Author

Nhung, Nguyen Thi, primary, Yen, Nguyen Thi Phuong, additional, Dung, Nguyen Thi Thuy, additional, Nhan, Nguyen Thi Minh, additional, Phu, Doan Hoang, additional, Kiet, Bach Tuan, additional, Thwaites, Guy, additional, Geskus, Ronald B., additional, Baker, Stephen, additional, Carrique-Mas, Juan, additional, and Choisy, Marc, additional

Published
2022
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46. The Natural History and Transmission Potential of Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Author

Van Vinh Chau, Nguyen, Lam, Vo Thanh, Dung, Nguyen Thanh, Yen, Lam Minh, Minh, Ngo Ngoc Quang, Hung, Le Manh, Ngoc, Nghiem My, Dung, Nguyen Tri, Man, Dinh Nguyen Huy, Nguyet, Lam Anh, Nhat, Le Thanh Hoang, Nhu, Le Nguyen Truc, Ny, Nguyen Thi Han, Hong, Nguyen Thi Thu, Kestelyn, Evelyne, Dung, Nguyen Thi Phuong, Xuan, Tran Chanh, Hien, Tran Tinh, Phong, Nguyen Thanh, Tu, Tran Nguyen Hoang, Geskus, Ronald B, Thanh, Tran Tan, Truong, Nguyen Thanh, Binh, Nguyen Tan, Thuong, Tang Chi, Thwaites, Guy, Van Tan, Le, Loan, Huynh Thi, Van Hao, Nguyen, Thuy, Duong Bich, Lan, Nguyen Phu Huong, Thoa, Pham Thi Ngoc, Thao, Tran Nguyen Phuong, Phuong, Tran Thi Lan, Uyen, Le Thi Tam, Tam, Tran Thi Thanh, That, Bui Thi Ton, Nhung, Huynh Kim, Tai, Ngo Tan, Vuong, Vo Trong, Ty, Dinh Thi Bich, Dung, Le Thi, Uyen, Thai Lam, Tien, Nguyen Thi My, Thao, Ho Thi Thu, Thao, Nguyen Ngoc, Vuong, Huynh Ngoc Thien, Thao, Pham Ngoc Phuong, Phuong, Phan Minh, Tam, Dong Thi Hoai, Joseph, Donovan, Geskus, Ronald, van Doorn, H Rogier, Van Hien, Ho, Huy, Huynh Le Anh, Ha, Huynh Ngan, Yen, Huynh Xuan, Van Nuil, Jennifer, Day, Jeremy, Donovan, Joseph, Lawson, Katrina, Odette, Sonia Lewycka, Thwaites, Louise, Rabaa, Maia, Choisy, Marc, Chambers, Mary, Rahman, Motiur, Hoa, Ngo Thi, Nhien, Nguyen Thanh Thuy, Tuyen, Nguyen Thi Kim, Truong, Nguyen Xuan, Khanh, Phan Nguyen Quoc, Yen, Phung Le Kim, Yacoub, Sophie, Kesteman, Thomas, Thuong, Nguyen Thuy Thuong, Hang, Vu Thi Ty, and Nga, Le Hong

Subjects
0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Saliva, coronaviruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Infections, Asymptomatic, Virus, 03 medical and health sciences, COVID-19 (Disease), 0302 clinical medicine, Internal medicine, Throat, Major Article, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, SARS-CoV-2, business.industry, pandemic, COVID-19, 3. Good health, Natural history, AcademicSubjects/MED00290, 030104 developmental biology, Infectious Diseases, medicine.anatomical_structure, Vietnam, RNA, Viral, medicine.symptom, business, Viral load
Abstract

BackgroundLittle is known about the natural history of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.MethodsWe conducted a prospective study at a quarantine center for coronavirus disease 2019 in Ho Chi Minh City, Vietnam. We enrolled quarantined people with reverse-transcription polymerase chain reaction (RT-PCR)–confirmed SARS-CoV-2 infection, collecting clinical data, travel and contact history, and saliva at enrollment and daily nasopharyngeal/throat swabs (NTSs) for RT-PCR testing. We compared the natural history and transmission potential of asymptomatic and symptomatic individuals.ResultsBetween 10 March and 4 April 2020, 14 000 quarantined people were tested for SARS-CoV-2; 49 were positive. Of these, 30 participated in the study: 13 (43%) never had symptoms and 17 (57%) were symptomatic. Seventeen (57%) participants imported cases. Compared with symptomatic individuals, asymptomatic people were less likely to have detectable SARS-CoV-2 in NTS collected at enrollment (8/13 [62%] vs 17/17 [100%]; P = .02). SARS-CoV-2 RNA was detected in 20 of 27 (74%) available saliva samples (7 of 11 [64%] in the asymptomatic group and 13 of 16 [81%] in the symptomatic group; P = .56). Analysis of RT-PCR positivity probability showed that asymptomatic participants had faster viral clearance than symptomatic participants (P ConclusionsAsymptomatic SARS-CoV-2 infection is common and can be detected by analysis of saliva or NTSs. The NTS viral loads fall faster in asymptomatic individuals, but these individuals appear able to transmit the virus to others.

Published
2020

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