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1. Feasibility and Initial Outcomes of a Group-Based Teletherapy Psychiatric Day Program for Adults With Serious Mental Illness: Open, Nonrandomized Trial in the Context of COVID-19

Author

Puspitasari, Ajeng J, Heredia, Dagoberto, Coombes, Brandon J, Geske, Jennifer R, Gentry, Melanie T, Moore, Wendy R, Sawchuk, Craig N, and Schak, Kathryn M

Subjects
Psychology, BF1-990
Abstract

BackgroundIn the context of the COVID-19 pandemic, many behavioral health services have transitioned to teletherapy to continue delivering care for patients with mental illness. Studies that evaluate the outcome of this rapid teletherapy adoption and implementation are pertinent. ObjectiveThis single-arm, nonrandomized pilot study aimed to assess the feasibility and initial patient-level outcomes of a psychiatric transitional day program that switched from an in-person group to a video teletherapy group during the COVID-19 pandemic. MethodsPatients with transdiagnostic conditions who were at risk of psychiatric hospitalization were referred to the Adult Transitions Program (ATP) at a large academic medical center in the United States. ATP was a 3-week intensive outpatient program that implemented group teletherapy guided by cognitive and behavioral principles delivered daily for 3 hours per day. Feasibility was assessed via retention, attendance rate, and rate of securing aftercare appointments prior to ATP discharge. Patients completed standardized patient-reported outcome measures at admission and discharge to assess the effectiveness of the program for improving quality of mental health, depression, anxiety, and suicide risk. ResultsPatients (N=76) started the program between March and August of 2020. Feasibility was established, with 70 of the 76 patients (92%) completing the program and a mean attendance of 14.43 days (SD 1.22); also, 71 patients (95%) scheduled at least one behavioral health aftercare service prior to ATP discharge. All patient-level reported outcomes demonstrated significant improvements in depression (95% CI –3.6 to –6.2; Cohen d=0.77; P

Published
2021
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6. Can adolescents with eating disorders be treated in primary care? A retrospective clinical cohort study

Author

Lebow, Jocelyn, Mattke, Angela, Narr, Cassandra, Partain, Paige, Breland, Renee, Gewirtz O’Brien, Janna R, Geske, Jennifer, Billings, Marcie, Clark, Matthew M, Jacobson, Robert M, Phelan, Sean, Harbeck-Weber, Cynthia, Le Grange, Daniel, and Sim, Leslie

Subjects
Health Sciences, Psychology, Brain Disorders, Eating Disorders, Anorexia, Pediatric, Clinical Research, Health Services, Mental Health, Nutrition, Serious Mental Illness, Mental health, Good Health and Well Being, Feeding and eating disorders, Anorexia nervosa, Primary health care, Adolescent, Pediatrics, Nutrition and Dietetics, Health sciences
Abstract

BackgroundFamily-Based Treatment (FBT) is considered the first-line intervention for adolescent anorexia nervosa. However, access to this treatment is limited. Treatment programs for other pediatric mental health conditions have successfully overcome barriers to accessing evidence-based intervention by integrating mental health services into primary care. This study evaluated the proof-of-concept of a novel modification of FBT, Family-Based Treatment for Primary Care (FBT-PC) for adolescent restrictive eating disorders designed for delivery by primary care providers in their practices.MethodsThis retrospective clinical cohort study evaluated 15 adolescents with restrictive eating disorders receiving FBT-PC and 15 adolescents receiving standard FBT. We examined improvement in BMI percentile, reduction in weight suppression, and clinical benchmarks of eating disorder recovery including weight restoration to > 95% of expected body weight (EBW) and resolution of DSM-5 criteria for eating disorders.ResultsIn both groups, effect sizes for increased BMI percentile exceeded Cohen's convention for a large effect (FBT-PC: d = .94; standard FBT: d = 1.15) as did effect sizes for reduction in weight suppression (FBT-PC: d = 1.83; standard FBT: d = 1.21). At the end of treatment, 80% of the FBT-PC cohort and 87% in the standard FBT group achieved > 95%EBW and 67% in the FBT-PC group and 60% in the standard FBT group no longer met DSM-5 criteria for an eating disorder. There were no cohort differences in the number of treatment drop-outs or referrals to a more intensive level of eating disorder treatment.ConclusionsFindings suggest that primary care providers have potential to improve weight and clinical status in adolescents with restrictive eating disorders. Based on these results, more rigorous testing of the FBT-PC model is warranted.

Published
2021

8. A primary care modification of family-based treatment for adolescent restrictive eating disorders

Author

Lebow, Jocelyn, O’Brien, Janna R Gewirtz, Mattke, Angela, Narr, Cassandra, Geske, Jennifer, Billings, Marcie, Clark, Matthew M, Jacobson, Robert M, Phelan, Sean, Le Grange, Daniel, and Sim, Leslie

Subjects
Health Services and Systems, Health Sciences, Health Services, Mental Health, Nutrition, Eating Disorders, Clinical Research, Pediatric, 6.6 Psychological and behavioural, Management of diseases and conditions, Evaluation of treatments and therapeutic interventions, 7.1 Individual care needs, Good Health and Well Being, Adolescent, Body Mass Index, Child, Feeding and Eating Disorders, Health Personnel, Humans, Pilot Projects, Primary Health Care, Medical and Health Sciences, Studies in Human Society, Psychology and Cognitive Sciences, Clinical Psychology, Health sciences, Human society, Psychology
Abstract

Although eating disorders pose a significant threat to the health and well-being of children and adolescents, due to a profound scarcity of specialty providers, only a small percentage of patients receives evidence-based treatment. To improve access to care for restrictive eating disorders, we developed a modified version of Family-Based Treatment to be delivered by primary care providers (PCPs) and conducted a pilot study to evaluate the feasibility and preliminary outcomes of this intervention. Fifteen adolescents (mean age = 15.5 years) with restrictive eating disorders and their caregiver(s) were enrolled in Family-Based Treatment for Primary Care (FBT-PC), delivered by three trained PCPs. Retention for the intervention was high (n = 13, 86.7%). Over the course of 3 months, participants attended an average of 9.2 (SD = 2.8) sessions and experienced a significant increase in BMI percentile from 39.1 to 54.8 (t (13) = -6.71, p < .001; d = .61). FBT-PC appears to be feasible for implementation in the primary care setting and has the potential to improve access to treatment and yield positive outcomes for young patients with restrictive eating disorders.

Published
2021

10. Genetic predisposition to major depressive disorder differentially impacts alcohol consumption and high-risk drinking situations in men and women with alcohol use disorder

Author

Karpyak, Victor M., Coombes, Brandon J., Geske, Jennifer R., Pazdernik, Vanessa M., Schneekloth, Terry, Kolla, Bhanu Prakash, Oesterle, Tyler, Loukianova, Larissa L., Skime, Michelle K., Ho, Ada Man-Choi, Ngo, Quyen, Skillon, Cedric, Ho, Ming-Fen, Weinshilboum, Richard, and Biernacka, Joanna M.

Published
2023
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14. Genetic contributions to alcohol use disorder treatment outcomes: a genome-wide pharmacogenomics study

Author

Biernacka, Joanna M., Coombes, Brandon J., Batzler, Anthony, Ho, Ada Man-Choi, Geske, Jennifer R., Frank, Josef, Hodgkinson, Colin, Skime, Michelle, Colby, Colin, Zillich, Lea, Pozsonyiova, Sofia, Ho, Ming-Fen, Kiefer, Falk, Rietschel, Marcella, Weinshilboum, Richard, O’Malley, Stephanie S., Mann, Karl, Anton, Ray, Goldman, David, and Karpyak, Victor M.

Published
2021
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17. Efficacy and safety of transcranial magnetic stimulation on cognition in mild cognitive impairment, Alzheimer’s disease, Alzheimer’s disease-related dementias, and other cognitive disorders: a systematic review and meta-analysis

Author

Pagali, Sandeep R., primary, Kumar, Rakesh, additional, LeMahieu, Allison M., additional, Basso, Michael R., additional, Boeve, Bradley F., additional, Croarkin, Paul E., additional, Geske, Jennifer R., additional, Hassett, Leslie C., additional, Huston, John, additional, Kung, Simon, additional, Lundstrom, Brian N., additional, Petersen, Ronald C., additional, St. Louis, Erik K., additional, Welker, Kirk M., additional, Worrell, Gregory A., additional, Pascual-Leone, Alvaro, additional, and Lapid, Maria I., additional

Published
2024
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19. Deiodinase variation and liothyronine treatment interaction to accelerate ECT response in major depression: Pilot data and implications for thyroid pharmacogenomic testing in mood disorders

Author

Nuñez, Nicolas A, Sola, Christopher, Kung, Simon, Singh, Balwinder, Ozerdem, Aysegul, Veldic, Marin, Croarkin, Paul E., Moore, Katherine M., Betcher, Hannah K., Vande Voort, Jennifer L., Geske, Jennifer R., Biernacka, Joanna M., Rummans, Teresa A., Bahn, Rebecca S, and Frye, Mark A.

Published
2021
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20. Real-World Clinical Practice Among Patients With Bipolar Disorder and Chronic Kidney Disease on Long-term Lithium Therapy

Author

Kumar, Rakesh, Joseph, Boney, Pazdernik, Vanessa M., Geske, Jennifer, Nuñez, Nicolas A., Pahwa, Mehak, Kashani, Kianoush B., Veldic, Marin, Betcher, Hannah K., Moore, Katherine M., Croarkin, Paul E., Ozerdem, Aysegul, Cuellar-Barboza, Alfredo B., McElroy, Susan L., Biernacka, Joanna M., Frye, Mark A., and Singh, Balwinder

Published
2023
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22. The occurrence of mental health symptoms in isotretinoin‐treated adolescents.

Author

Miller, Keith, McKean, Alastair, Hand, Jennifer, Rackley, Sandra, Leung, Jonathan G., LeMahieu, Allison, Geske, Jennifer, and Bostwick, J. Michael

Subjects
MENTAL illness, PSYCHIATRIC diagnosis, TEENAGERS, PEOPLE with mental illness
Abstract

Background: Isotretinoin treatment for acne can reduce adverse psychiatric outcomes in adults, but there has been little investigation of the incidence of psychiatric outcomes in treated adolescents. Methods: This retrospective cohort study using the Rochester Epidemiology Project identified 606 patients aged 12–18 prescribed isotretinoin over a 10‐year period between January 1, 2008 and December 31, 2017. Medical records were reviewed to identify psychiatric diagnoses before and during isotretinoin therapy, as well as psychiatric symptoms not captured by formal diagnoses and changes to isotretinoin dosing because of psychiatric diagnoses or symptoms. Results: One hundred seventy‐seven (29.2%) had a psychiatric diagnosis prior to isotretinoin initiation, but 98 (16.2%) had a new psychiatric diagnosis or psychiatric symptom while taking isotretinoin. Patients with a psychiatric history were no more likely than those without to receive a new psychiatric diagnosis during treatment (4.5% vs. 3.7%; p =.650), but did experience more psychiatric symptoms, primarily low mood and mood swings (23.7% vs. 7.7%; p <.001). Only 25.5% of the 98 with a new psychiatric diagnosis or psychiatric symptom had a subsequent dose change. A dose change was more likely if patients received a new psychiatric diagnosis (41.7% vs. 20.3%; p =.037) or patients did not have a psychosocial explanation for psychiatric symptoms (34.4% vs. 10.8%; p =.009). Conclusions: A substantial proportion of adolescent patients prescribed isotretinoin had a prior psychiatric diagnosis. This predicts more psychiatric symptoms during isotretinoin treatment. Adolescents with a psychiatric history who have worsening symptoms and those with new‐onset psychiatric symptoms would benefit from close monitoring while taking isotretinoin. [ABSTRACT FROM AUTHOR]

Published
2024
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26. The impact of binge eating behavior on lithium- and quetiapine-associated changes in body weight, body mass index, and waist circumference during 6 months of treatment: Findings from the bipolar CHOICE study

Author

Yaramala, Satyanarayana R., McElroy, Susan L., Geske, Jennifer, Winham, Stacey, Gao, Keming, Reilly-Harrington, Noreen A., Ketter, Terence A., Deckersbach, Thilo, Kinrys, Gustavo, Kamali, Masoud, Sylvia, Louisa G., McInnis, Melvin G., Friedman, Edward S., Thase, Machael E., Kocsis, James H., Tohen, Mauricio, Calabrese, Joseph R., Bowden, Charles L., Shelton, Richard C., Nierenberg, Andrew A., and Bobo, William V.

Published
2020
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35. The Contribution of Psychological Symptoms to Cognitive Difficulties in Youth With Postural Orthostatic Tachycardia Syndrome and Chronic Pain.

Author

Tsai Owens, Michele, Fischer, Philip R., Sim, Leslie, Kirsch, Alexandra, Homan, Kendra, Zaccariello, Michael, Sawchuk, Nicholas, LeMahieu, Allison, Geske, Jennifer, and Harbeck-Weber, Cynthia

Subjects
POSTURAL orthostatic tachycardia syndrome, ORTHOSTATIC intolerance, PAIN catastrophizing, CHRONIC pain, SYMPTOMS, YOUNG adults
Abstract

Introduction: Subjectively experienced cognitive difficulties are common in youth with postural orthostatic tachycardia syndrome. The pathophysiological and psychological contributions of these cognitive impairments remain unclear. Method: Participants were 96 adolescents and young adults diagnosed with postural orthostatic tachycardia syndrome and admitted to an intensive pain treatment program. Participants completed cognitive assessment and measures of postural orthostatic tachycardia syndrome symptoms, pain intensity, pain catastrophizing, anxiety, depression, and functional disability. Results: Self-reported autonomic symptom intensity, but not severity of heart rate change, was associated with cognitive performance. Symptoms of depression were associated with decreases in most measures of cognitive functioning. Pain intensity, pain catastrophizing, and depression but not cognitive scores and physiological measures, were significant predictors of disability. Conclusion: Depression appears to be a significant contributor to the cognitive difficulties in youth with postural orthostatic tachycardia syndrome. These findings highlight the importance of assessing and treating affective symptoms in this population along with medical and lifestyle approaches to treating postural orthostatic tachycardia syndrome symptoms. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Long-term effects of premenopausal bilateral oophorectomy with or without hysterectomy on physical aging and chronic medical conditions

Author

Mielke, Michelle M., primary, Kapoor, Ekta, additional, Geske, Jennifer R., additional, Fields, Julie A., additional, LeBrasseur, Nathan K., additional, Morrow, Melissa M., additional, Winham, Stacey J., additional, Faubion, Laura L., additional, Castillo, Anna M., additional, Hofrenning, Ekaterina I., additional, Bailey, Kent R., additional, Rocca, Walter A., additional, and Kantarci, Kejal, additional

Published
2023
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37. Corrigendum to “Genetic predisposition to major depressive disorder differentially impacts alcohol consumption and high-risk drinking situations in men and women with alcohol use disorder” [Drug Alcohol Depend. 243 (2023) 109753]

Author

Karpyak, Victor M., primary, Coombes, Brandon J., additional, Geske, Jennifer R., additional, Pazdernik, Vanessa M., additional, Schneekloth, Terry, additional, Kolla, Bhanu Prakash, additional, Oesterle, Tyler, additional, Loukianova, Larissa L., additional, Skime, Michelle K., additional, Ho, Ada Man-Choi, additional, Ngo, Quyen, additional, Skillon, Cedric, additional, Ho, Ming-Fen, additional, Weinshilboum, Richard, additional, and Biernacka, Joanna M., additional

Published
2023
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42. Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Author

Weivoda, Megan M., Chew, Chee Kian, Monroe, David G., Farr, Joshua N., Atkinson, Elizabeth J., Geske, Jennifer R., Eckhardt, Brittany, Thicke, Brianne, Ruan, Ming, Tweed, Amanda J., McCready, Louise K., Rizza, Robert A., Matveyenko, Aleksey, Kassem, Moustapha, Andersen, Thomas Levin, Vella, Adrian, Drake, Matthew T., Clarke, Bart L., Oursler, Merry Jo, and Khosla, Sundeep

Published
2020
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45. Longitudinal factors associated with increased alcohol consumption in adults during the COVID-19 pandemic

Author

Holland, Ashley L, primary, Sharma, Pravesh, additional, Kurani, Shaheen, additional, Pazdernik, Vanessa, additional, Patten, Christi, additional, Kremers, Hilal Maradit, additional, Croarkin, Paul, additional, Kamath, Celia, additional, Glasgow, Amy, additional, Sangaralingham, Lindsey, additional, Geske, Jennifer, additional, Prasad, Kavita, additional, and St. Sauver, Jennifer, additional

Published
2023
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