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5. Identifying Original and Restoration Materials through Spectroscopic Analyses on Saturnino Gatti Mural Paintings: How Far a Noninvasive Approach Can Go

Author

Bonizzoni, L, Caglio, S, Galli, A, Germinario, C, Izzo, F, Magrini, D, Bonizzoni, Letizia, Caglio, Simone, Galli, Anna, Germinario, Chiara, Izzo, Francesco, Magrini, Donata, Bonizzoni, L, Caglio, S, Galli, A, Germinario, C, Izzo, F, Magrini, D, Bonizzoni, Letizia, Caglio, Simone, Galli, Anna, Germinario, Chiara, Izzo, Francesco, and Magrini, Donata

Abstract

This paper presents the results obtained for the mural paintings (XV century CE) in the church of San Panfilo in Villagrande di Tornimparte (AQ, Italy) by means of noninvasive spectroscopic techniques; this research is a part of the project on the Saturnino Gatti pictorial cycle, promoted and coordinated by the AIAr (the Italian Archaeometry Association). Digital optical microscopy (OM), X-ray fluorescence spectroscopy (XRF), fiber optics reflectance spectroscopy in the UV–Vis–NIR range (FORS), Fourier transform infrared spectroscopy in the external reflection mode (ER-FTIR), and Raman spectroscopy were performed on the points selected based on the image analysis results and the few available records on previous intervention, with the aim of characterizing both the original and restoration organic and inorganic materials. The synergic application of complementary techniques allowed us to obtain a complete picture of the palette and the main alteration products and organic substances (of rather ubiquitous lipid materials and less widespread resin and proteinaceous materials in specific points). The identification of modern compounds permitted the individuation of restoration areas; this was confirmed by the comparison with multiband imaging results, as in the case of specific green and blue pigments, strictly related to the presence of high signals of zinc. This analytical protocol left only very few ambiguities and allowed to minimizing the number of samples taken to clarifying, by sample laboratory analyses, the few doubts still open.

Published
2023

11. May a comprehensive mineralogical study of a jackstone calculus and some other human bladder stones unveil health and environmental implications?

Author

Mercurio, M., primary, Izzo, F., additional, Gatta, Giacomo Diego, additional, Salzano, L., additional, Lotrecchiano, G., additional, Saldutto, P., additional, Germinario, C., additional, Grifa, C., additional, Varricchio, E., additional, Carafa, A., additional, Di Meo, Maria Chiara, additional, and Langella, A., additional

Published
2021
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14. Mortar radiocarbon dating: Cryo2sonic sample preparation procedure. method and applications

Author

Ricci P., Germinario C., Lubritto C., Ricci, P., Germinario, C., and Lubritto, C.

Subjects
Mortar, Radiocarbon dating, Cryo2Sonic method, Characterization tecnique, Chronology
Abstract

The absolute chronology of archaeological contexts is mainly based on the radiocarbon dating of organic materials. This analytical approach often provides misleading results when the goal is to find a surprising relationship between organic matter and archaeological structures. Thus, discovering new radiocarbon dating methodologies on mortar samples, represents one of the main “open problems” involving the entire radiocarbon community. Mortars are heterogeneous building materials composed of a mixture of inorganic and/or organic binders, and inert with sandy dimensions. Indeed, the lime binder in mortar can be used to date archaeological structures, since the carbon dioxide absorbed during the setting of the mortar probably reflects the14C content existing in the atmosphere at that time. The main sources of carbon dioxide, that potentially contribute to a biasing in the final measure, are: the residues of primary carbonates (calcination relics) originating from the incomplete limestone combustion during the process of producing lime; aggregates containing carbonates used as inert materials during the production phases of the mortar; and newly formed carbonates precipitated after the interaction between running water or rain. Therefore, the preparation of the samples must eliminate the contamination (aggregate, calcination relics or crystallization of new calcite) which must be separated from the carbon belonging to the original binder. The methods, now more commonly used for the preparation of mortar samples, consist of a mechanical pre-treatment or a chemical treatment. This paper illustrates the so-called Cryo2Sonic procedure, and how it has been improved over time (previously it was “CryoSonic”), and developed with the use of other complementary techniques. Moreover, various case studies will be presented in which this radiocarbon dating protocol has been applied to mortars of different structures belonging to different phases and historical contexts. The results have not always been good, as there are many sources of contamination from the different origins of CO2. Our goal is to eliminate contamination as much as possible, or at least try to limit the effect of CO2 contamination.

Published
2019

15. Results of diagnostic campaign promoted by AIAr in the deposits of the Archaeological Museum of Paestum

Author

Oddo, M, Ricci, P, Angelici, D, Fantino, F, Sibilia, E, Alberghina, M, Schiavone, S, Grifa, C, Mercurio, M, Germinario, C, Izzo, F, Langella, A, Massa, E, Bracci, S, Magrini, D, Costa, R, Pelagotti, A, Zuchtriegel, G, Lubritto, C, Oddo, M. E, Ricci, P., Angelici, D., Fantino, F., Sibilia, E., Alberghina, M. F, Schiavone, S., Grifa, C., Mercurio, M., Germinario, C., Izzo, F., Langella, A., Massa, E., Bracci, S., Magrini, D., Costa, R., Pelagotti, A., Zuchtriegel, G., Lubritto, C., Oddo, M, Ricci, P, Angelici, D, Fantino, F, Sibilia, E, Alberghina, M, Schiavone, S, Grifa, C, Mercurio, M, Germinario, C, Izzo, F, Langella, A, Massa, E, Bracci, S, Magrini, D, Costa, R, Pelagotti, A, Zuchtriegel, G, Lubritto, C, Oddo, M. E, Ricci, P., Angelici, D., Fantino, F., Sibilia, E., Alberghina, M. F, Schiavone, S., Grifa, C., Mercurio, M., Germinario, C., Izzo, F., Langella, A., Massa, E., Bracci, S., Magrini, D., Costa, R., Pelagotti, A., Zuchtriegel, G., and Lubritto, C.

Abstract

Thirty artefacts from the Archaeological Park of Paestum were investigated by means of scientific techniques on the occasion of the 2016 exhibition 'Possessione. Trafugamenti e falsi di antichita a Paestum'. The multi-analytic diagnostic campaign was aimed at identifying forgeries. Results provided a deeper understanding of both ancient technology and contemporary forgery techniques.

Published
2018

17. Non-invasive characterization of the pigment’s palette used on the painted tomb slabs at Paestum archaeological site

Author

Alberghina, M. F., primary, Germinario, C., additional, Bartolozzi, G., additional, Bracci, S., additional, Grifa, C., additional, Izzo, F., additional, La Russa, M.F., additional, Magrini, D., additional, Massa, E., additional, Mercurio, M., additional, Mollica Nardo, V., additional, Oddo, M.E., additional, Pagnotta, S. M., additional, Pelagotti, A., additional, Ponterio, R. C., additional, Ricci, P., additional, Rovella, N., additional, Ruffolo, S. A., additional, Schiavone, S., additional, Spagnuolo, A., additional, Vetromile, C., additional, Zuchtriegel, G., additional, and Lubritto, C., additional

Published
2020
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19. Raw materials for ancient ceramic productions from Campania region: provenance studies by means of Sr-Nd isotopes

Author

Morra V., Arienzo I., D’Antonio M., De Bonis A., Germinario C., Grifa C., Guarino V., Langella A., Società Geologica Italiana, Morra, V., Arienzo, I., D’Antonio, M., De Bonis, A., Germinario, C., Grifa, C., Guarino, V., and Langella, A.

Subjects
Sr-Nd isotopes, archaeological pottery, provenance
Abstract

When archaeometric studies on archaeological ceramics are performed, one of the most important questions asked by archaeologists is the provenance of pottery. This is usually performed by comparing mineropetrographic and chemical composition of ceramics with that of local raw materials (clays, temper), production indicators and appropriate reference groups. Nevertheless, the commonly-used analytical techniques (e.g. OM, SEM-EDS, XRF, ICP-MS) may not always be helpful for the determination of provenance. Indeed, processing of raw materials, such as tempering or levigation, can significantly modify their original chemical composition, sometimes leading to an ineffective identification of raw material resources. For this reason, a pioneering analytical approach has been recently applied by measuring the Sr and Nd isotopic signature. Isotope analysis has largely used in archaeological sciences to date objects and identify their provenance, making it also a useful tool for the determination of provenance of ceramic vessels (De Bonis et al., 2018 and references therein). For this study, 87Sr/86Sr and 143Nd/144Nd isotope ratios were measured on archaeological pottery from Campania and raw materials (clays and volcanic temper) exploited in antiquity for producing ceramics. The analyses were focused on samples from both the Bay of Naples and Southern Campania. The isotope signatures allowed us to better discriminate among different productions and find a strong relationship between the archaeological pottery and the geological sources of raw materials. In order to validate the method, Sr-Nd isotope ratios were also measured for the first time on experimental ceramic materials that replicate archaeological pottery (De Bonis et al., 2018). It was interesting to note that synthetic mixtures used for the ceramic replicas plot exactly on the theoretical mixing curve between the clay and volcanic temper end-members. This suggests that the artificial manipulation of raw materials (firing, levigation, tempering) induces no significant variations to the Sr-Nd isotope fingerprint, which strictly depends on the geochemical affinity of the raw materials. Thus, isotopic analysis can be considered as an effective and robust method that could complement the common multi-analytical approach in order to more precisely constrain potential geological sources for ceramic materials and pottery provenance. De Bonis, A., Arienzo I., D’Antonio, M., Franciosi, L., Germinario, C., Grifa, C., Guarino, V., Langella, A. & Morra, V. (2018): Sr-Nd isotopic fingerprint as a tool for ceramic provenance: application on raw materials, ceramic replicas and ancient pottery. J. Archaeol. Sci., 94, 51-59.

Published
2018

20. Interim 2017/18 influenza seasonal vaccine effectiveness: combined results from five European studies

Author

Rondy, M, Kissling, E, Emborg, Hd, Gherasim, A, Pebody, R, Trebbien, R, Pozo, F, Larrauri, A, Mcmenamin, J, Valenciano, M, Kaic, B, Kurecic Filipovic, S, Visekruna-Vucina, V, Pem Novosel, I, Lovric, Z, Petrović, G, Krause, Tg, Fischer, Tk, Lina, B, Falchi, Antonella, Vilcu, Am, Souty, C, Blanchon, T, van der Werf, S, Enouf, V, Behillil, S, Valette, M, Bernard-Stoecklin, S, Lévy-Bruhl, D, Launay, O, Loulergue, P, Lenzi, N, Lesieur, Z, L'Honneur, As, Galtier, F, Agostini, C, Serrand, C, Merle, C, Foulongne, V, Vanhems, P, Lainé, F, Lagathu, G, Carrat, F, Buda, S, Preuss, U, Prahm, K, Schweiger, B, Wedde, M, Heider, A, Martin, M, Biere, B, Duerrwald, R, Domegan, L, Coughlan, L, O’Donnell, J, Joyce, M, Collins, C, Dunford, L, Martin Moran, Josè Manuel, Tuite, G, Duffy, M, Connell, J, de Gascun, C, Rizzo, C, Bella, A, Alfonsi, V, Castrucci, Mr, Puzelli, S, Pagani, E, Ghisetti, V, Pariani, E, Baldanti, F, Palù, G, D'Agaro, P, Ansaldi, F, Affanni, P, Rossolini, Gm, Camilloni, B, Bagnarelli, P, Sanguinetti, M, Atripaldi, L, Chironna, M, Serra, C, Vitale, F, Germinario, C, Orsi, A, Manini, I, Montomoli, E, Napoli, C, Orsi, Gb, Casado, I, Castilla, J, Fernandino, L, Martínez-Baz, I, Ezpeleta, G, Navascués, A, Pérez-García, A, Aguinaga, A, Ezpeleta, C, Meijer, A, van den Brink, S, van der Hoek, W, Goderski, G, Wijsman, L, Bagheri, M, Dijkstra, F, de Lange, M, Marzec, T, Overduin, P, Teirlinck, A, Wentink, E, Donker, G, Marbus, S, van Gageldonk- Lafeber, R, Schneeberger, P, van Oosterheert JJ, Schweitzer, V, Groeneveld, G, Nunes, B, RIBEIRO MACHADO, CARLOS AUGUSTO, Rodrigues, Ap, DIAZ GOMEZ, MARIA VANESSA, Kislaya, I, Guiomar, R, Pechirra, P, Cristóvão, P, Costa, I, Panarra, A, Côrte-Real, R, Poças, J, João Peres, M, García Comas, L, Marisquerena, Mei, Galán, Jc, Folgueira, D, Gonzalez Carril, F, Sancho Martínez, R, Cilla, G, García Cenoz, M, Quiñones Rubio, C, Martinez Ochoa, E, Blasco, M, Gimenez Duran, J, Vanrell, Jm, Reina, J, Castrillejo, D, Gherasim, Am, Delgado, C, Oliva, J, Casas, I, García, M, Latorre, M, Milagro Beamonte AM, Martinez Sapiñ, A, Oribe Amores, M, Aizpurúa, A, Montes, Marco, Zakikhany, K, Brytting, M, Wiman, Å, Carnahan, A, Warburton, F, Djennad, A, Ellis, J, Andrews, N, Marques, D, Cottrell, S, Reynolds, Alexander, Gunson, R, Galiano, M, Lackenby, A, Robertson, C, O’Doherty, M, Sinnathamby, M, Yonova, I, Moore, C, Sartaj, M, de Lusignan, S, Zambon, M, Moren, A, Penttinen, P., Unión Europea, EpiConcept [Paris], Statens Serum Institut [Copenhagen], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Rondy M., Kissling E., Emborg H.-D., Gherasim A., Pebody R., Trebbien R., Pozo F., Larrauri A., McMenamin J., Valenciano M., Kaic B., Filipovic S.K., Visekruna-Vucina V., Novosel I.P., Lovric Z., Petrovic G., Krause T.G., Fische T.K., Lina B., Falchi A., Vilcu A.-M., Souty C., Blanchon T., van der Werf S., Enouf V., Behillil S., Valette M., Bernard-Stoecklin S., Levy-Bruhl D., Launay O., Loulergue P., Lenzi N., Lesieur Z., L'Honneur A.-S., Galtier F., Agostini C., Serrand C., Merle C., Foulongne V., Vanhems P., Laine F., Lagathu G., Carrat F., Buda S., Preuss U., Prahm K., Schweiger B., Wedde M., Heider A., Martin M., Biere B., Duerrwald R., Domegan L., Coughlan L., O'Donnell J., Joyce M., Collins C., Dunford L., Moran J., Tuite G., Duffy M., Connell J., de Gascun C., Rizzo C., Bella A., Alfonsi V., Castrucci M.R., Puzelli S., Pagani E., Ghisetti V., Pariani E., Baldanti F., Palu G., D'Agaro P., Ansaldi F., Affanni P., Rossolini G.M., Camilloni B., Bagnarelli P., Sanguinetti M., Atripaldi L., Chironna M., Serra C., Vitale F., Germinario C., Orsi A., Manini I., Montomoli E., Napoli C., Orsi G.B., Casado I., Castilla J., Fernandino L., Martinez-Baz I., Ezpeleta G., Navascues A., Perez-Garcia A., Aguinaga A., Ezpeleta C., Meijer A., van den Brink S., van der Hoek W., Goderski G., Wijsman L., Bagheri M., Dijkstra F., de Lange M., Marzec T., Overduin P., Teirlinck A., Wentink E., Donker G., Marbus S., van Gageldonk-Lafeber R., Schneeberger P., van Oosterheert J.J., Schweitzer V., Groeneveld G., Nunes B., Machado A., Rodrigues A.P., Gomez V., Kislaya I., Guiomar R., Pechirra P., Cristovao P., Costa I., Panarra A., Corte-Real R., Pocas J., Peres M.J., Comas L.G., Marisquerena M.E.I., Galan J.C., Folgueira M.D., Carril F.G., Martinez R.S., Cilla G., Cenoz M.G., Rubio C.Q., Ochoa E.M., Blasco M., Duran J.G., Vanrell J.M., Reina J., Castrillejo D., Gherasim A.M., Delgado C., Oliva J., Casas I., Garcia M., Latorre M., Beamonte A.M.M., Sapina A.M., Amores M.O., Aizpurua A., Montes M., Zakikhany K., Brytting M., Wiman A., Carnahan A., Warburton F., Djennad A., Ellis J., Andrews N., Marques D., Cottrell S., Reynolds A., Gunson R., Galiano M., Lackenby A., Robertson C., O'Doherty M., Sinnathamby M., Yonova I., Moore C., Sartaj M., de Lusignan S., Zambon M., Moren A., Penttinen P., Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Marc, Rondy, Esther, Kissling, Hanne-Dorthe, Emborg, Alin, Gherasim, Richard, Pebody, Ramona, Trebbien, Francisco, Pozo, Amparo, Larrauri, Jim, Mcmenamin, Marta, Valenciano, D'Agaro, Pierlanfranco, De Lusignan, S, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier )-Université de Montpellier (UM)

Subjects
0301 basic medicine, Male, Pediatrics, Epidemiology, viruses, Influenza B viru, influenza, influenza vaccine effectiveness, influenza vaccination, case control study, multicentre study, Europe, Europe, case control study, influenza, influenza vaccination, influenza vaccine effectiveness, multicentre study, 0302 clinical medicine, Influenza A Virus, H1N1 Subtype, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Interim, Pandemic, Influenza A Virus, 030212 general & internal medicine, QA, Influenza vaccine effectiveness, Child, media_common, Vaccine Effectiveness, Vaccination, virus diseases, Middle Aged, 3. Good health, Treatment Outcome, Influenza Vaccines, Child, Preschool, H3N2 Subtype, Female, Seasons, Influenza Vaccine, Rapid Communication, Human, Adult, RM, medicine.medical_specialty, Adolescent, Influenza vaccine, 030106 microbiology, Case control study, Multicentre study, European studies, Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA, 03 medical and health sciences, Virology, Influenza, Human, medicine, media_common.cataloged_instance, Humans, H1N1 Subtype, Vacina Antigripal, European Union, European union, Preschool, Pandemics, Aged, Influenza A Virus, H3N2 Subtype, Cuidados de Saúde, Public Health, Environmental and Occupational Health, Infant, Newborn, Infant, Influenza a, influenza vaccine effectivene, Newborn, Influenza, respiratory tract diseases, Influenza vaccination, Influenza B virus, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Determinantes da Saúde e da Doença, [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology
Abstract

Between September 2017 and February 2018, influenza A(H1N1)pdm09, A(H3N2) and B viruses (mainly B/Yamagata, not included in 2017/18 trivalent vaccines) co-circulated in Europe. Interim results from five European studies indicate that, in all age groups, 2017/18 influenza vaccine effectiveness was 25 to 52% against any influenza, 55 to 68% against influenza A(H1N1)pdm09, -42 to 7% against influenza A(H3N2) and 36 to 54% against influenza B. 2017/18 influenza vaccine should be promoted where influenza still circulates. Funding: The five studies have received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 634446 to conduct the study in individuals aged 65 years or more. ECDC has contributed to fund some study sites of the EU-PC study under the Framework contract No ECDC/2014/026 for the individuals aged less than 65 years. All study teams are very grateful to all patients, general practitioners, paediatricians, hospital teams, laboratory teams, regional epidemiologists who have contributed to the studies. We acknowledge the authors, originating and submitting laboratories of the sequences from GISAID’s EpiFlu Database used for this study. All submitters of data may be contacted directly via the GISAID website www.gisaid.org Sí

Published
2018

21. [The health determinants in young children: testing a new surveillance system in Italy]

Author

Pizzi, E., Spinelli, A., Battilomo, S., Azzarito, C., Balducci, M. T., Bettinelli, M. E., Campostrini, S., Germinario, C., Mazzarella, Guido, Mignuoli, A. D., Morbidoni, M., Porchia, Stefania, Simeoni, Loris, Speri, Laura, Bucciarelli, M., Buoncristiano, M., Lauria, L., Nardone, P., Privitera, M. G., Brancati, G., Raffa, R., Napoli, T., Cimminelli, L., Vitelli, A., Panico, M., Ragone, G., D'Anna, A., Nardacci, A., Benedetti, E., Ambrogiani, E., Guidi, A., Cimini, D., Marcolini, P., Pasqualini, F., Rossini, Roberta, Zappi, W., Lacaita, G., Valentini, M., Pedote, P. D., Pesare, A., Caputi, G., Gottardello, L., and Campi, Davide

Subjects
Vaccination centres, Childhood, Health determinants, Surveillance system, Italy, Child, Preschool, Population Surveillance, Child Health, Humans, Infant, Settore SECS-S/05 - Statistica Sociale
Abstract

In recent years, the scientific community has stressed the need to invest in the first 1,000 days of life - the time spanning between conception and the 2nd birthday - because it is during this period that the foundations of health are laid and whose effects will be present throughout the life and may influence the next generation. Taking this into account, in 2013 the National Centre for Disease Prevention and Control (CCM) of the Italian Ministry of Health promoted and financed a project to test a surveillance system of the main determinants of health concerning the child between the conception period and the 2nd years of life which are included in the National Programme "GenitoriPiù": folic acid before and during pregnancy, abstention from tobacco and alcohol during pregnancy and lactation, breastfeeding, infant sleep position, vaccination attitude, and early reading. The Project, started in January 2014 and ended in August 2016, has piloted the design, testing, and evaluation of the surveillance system with the view to national extension and the repeatability over time. The surveillance system has been designed to collect data through a questionnaire compiled by mothers in vaccination centres, in order to produce indicators which will enable territorial and intertemporal comparisons to be made. The project has shown the feasibility of this system, identifying favourable conditions and possible difficulties, and its ability to collect important information on children's health.

Published
2019

22. Moderate influenza vaccine effectiveness against A(H1N1)pdm09 virus, and low effectiveness against A(H3N2) subtype, 2018/19 season in Italy

Author

Bellino, S., Bella, A., Puzelli, S., Di Martino, A., Facchini, M., Punzo, O., Pezzotti, P., Castrucci, M.R., Di Mario, G., Calzoletti, L., Fabiani, C., Chironna, M., Germinario, C., Tramuto, F., Di Carlo, V., Affanni, P., Grazia Pascucci, M., D'Agaro, P., Gallo, T., Pagani, E., Natter, B., Camilloni, B., Tosti, A., Pariani, E., Senatore, S., Serra, C., Rita Tanchis, P., Ghisetti, V., Tiberti, D., Romano, L., Volpe, E., Giannecchini, S., and Bellino S, Bella A, Puzelli S, Di Martino A, Facchini M, Punzo O, Pezzotti P, Castrucci MR, Tramuto F, The InfluNet Study Group.

Subjects
Male, test-negative case-control study, 0301 basic medicine, Prevalence, Influenza vaccine effectiveness, test-negative case-control study, national influenza surveillance network, Italy, Settore MED/42 - Igiene Generale E Applicata, Influenza A Virus, H1N1 Subtype, 0302 clinical medicine, Drug Discovery, Epidemiology, 030212 general & internal medicine, Child, Influenza vaccine effectiveness, Aged, 80 and over, national influenza surveillance network, Age Factors, virus diseases, Middle Aged, 3. Good health, Vaccination, Treatment Outcome, Italy, Influenza Vaccines, Child, Preschool, Molecular Medicine, Female, Adult, medicine.medical_specialty, Adolescent, Influenza vaccine, Immunology, Context (language use), Virus, Young Adult, 03 medical and health sciences, Internal medicine, Influenza, Human, medicine, Animals, Humans, Aged, Pharmacology, business.industry, Influenza A Virus, H3N2 Subtype, Case-control study, Infant, 030104 developmental biology, Immunization, Case-Control Studies, business
Abstract

Background: Influenza vaccines are updated every year to match the vaccine strains with currently circulating viruses; consequently influenza vaccine effectiveness (IVE) has to be assessed annually.Research design and methods: A test-negative case-control study was conducted within the context of the Italian sentinel influenza surveillance network to estimate IVE by age group, virus subtype, and vaccine brand in medically attended laboratory-confirmed influenza.Results: In Italy, the 2018/19 influenza season was characterized by the co-circulation of influenza A(H1N1)pdm09 and A(H3N2) viruses. The adjusted IVE estimate in preventing influenza was moderate (44.8%, 95% CI: 18.8 to 62.5) against A(H1N1)pdm09, whereas there was no evidence of effectiveness (1.8%, 95% CI: -37.8 to 30.1) in persons affected by A(H3N2). IVE against A(H1N1)pdm09 decreased with age ranging from 65.7% to 13.1% among children/adolescents and elderly, respectively; moreover results suggest that Vaxigrip Tetra® was more effective against A(H1N1)pdm09 compared to Fluarix Tetra® [62.5% (95% CI: 34.3 to 78.6) vs 24.5% (95% CI: -40.6 to 59.6)]. Low effectiveness (35.2%, 95% CI: -50.8 to 72.1) against A(H3N2) was detected only in the elderly immunized with Fluad®.Conclusions: Findings suggest that influenza vaccines were low to moderately effective, probably due to a mismatch between circulating and vaccine strains.

Published
2019
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26. Raw materials for archaeological pottery: a multianalytical approach

Author

De Bonis, A., Arienzo, I., Germinario, C., Aiello, G., D'ANTONIO, MASSIMO, GRIFA, Celestino, GUARINO, VINCENZA, LANGELLA, ALESSIO, MERCURIO, MARIANO, AMORE, FILOMENA ORNELLA, BARRA, DIANA, MORRA, VINCENZO, De Bonis, A., Arienzo, I., D'Antonio, Massimo, Germinario, C., Grifa, Celestino, Guarino, Vincenza, Langella, Alessio, Mercurio, Mariano, Amore, FILOMENA ORNELLA, Barra, Diana, Aiello, G., and Morra, Vincenzo

Published
2016

27. Multi-analytical characterization and provenance identification of protohistoric metallic artefacts from Picentia-Pontecagnano and the Sarno valley sites, Campania, Italy

Author

Balassone, G, Mercurio, M, Germinario, C, Grifa, C, Villa, I, Di Maio, G, Scala, S, de’ Gennaro, R, Petti, C, Del Re, M, Langella, A, Balassone, Giuseppina, Mercurio, Mariano, Germinario, Chiara, Grifa, Celestino, Villa, Igor Maria, Di Maio, Giovanni, Scala, Serenella, de’ Gennaro, Roberto, Petti, Carmela, Del Re, Maria Carmela, Langella, Alessio, Balassone, G, Mercurio, M, Germinario, C, Grifa, C, Villa, I, Di Maio, G, Scala, S, de’ Gennaro, R, Petti, C, Del Re, M, Langella, A, Balassone, Giuseppina, Mercurio, Mariano, Germinario, Chiara, Grifa, Celestino, Villa, Igor Maria, Di Maio, Giovanni, Scala, Serenella, de’ Gennaro, Roberto, Petti, Carmela, Del Re, Maria Carmela, and Langella, Alessio

Abstract

Protohistoric metal objects coming from the archaeological sites of Pontecagnano (Salerno, Italy) and Striano (Naples, Italy), preserved in the Pontecagnano National Archaeological Museum and the Paleontological Museum of Naples University “Federico II” have been studied by means of an archaeometric approach. A multi-analytical procedure including X-ray powder diffraction (XRPD), scanning electron microscopy and energy dispersive X-ray spectroscopy (SEM-EDS), micro X-ray fluorescence (µ-XRF) and lead isotope ratio mass spectrometry (LIRMS), was used to characterize these objects thus providing hypotheses on the possible provenance of metallic raw materials. The investigated samples are represented by lead, silver, copper and tin bronze-based objects. Corrosion processes affecting the bronze objects were recognized as well as crusts and patinae at different stages of evolution. LIRMS analyses suggested that most of Pontecagnano artifacts were manufactured with metals from southern Tuscany, where important metal reserves were located. On the other hand, due to the limited number of samples, the provenance of the Striano objects cannot be unambiguously identified although data so far available suggest a Sardinian source.

Published
2018

28. Interim 2017/18 influenza seasonal vaccine effectiveness: Combined results from five European studies

Author

Rondy, M., Kissling, E., Emborg, H. -D., Gherasim, A., Pebody, R., Trebbien, R., Pozo, F., Larrauri, A., Mcmenamin, J., Valenciano, M., Kaic, B., Filipovic, S. K., Visekruna-Vucina, V., Novosel, I. P., Lovric, Z., Petrovic, G., Krause, T. G., Fische, T. K., Lina, B., Falchi, A., Vilcu, A. -M., Souty, C., Blanchon, T., van der Werf, S., Enouf, V., Behillil, S., Valette, M., Bernard-Stoecklin, S., Levy-Bruhl, D., Launay, O., Loulergue, P., Lenzi, N., Lesieur, Z., L'Honneur, A. -S., Galtier, F., Agostini, C., Serrand, C., Merle, C., Foulongne, V., Vanhems, P., Laine, F., Lagathu, G., Carrat, F., Buda, S., Preuss, U., Prahm, K., Schweiger, B., Wedde, M., Heider, A., Martin, M., Biere, B., Duerrwald, R., Domegan, L., Coughlan, L., O'Donnell, J., Joyce, M., Collins, C., Dunford, L., Moran, J., Tuite, G., Duffy, M., Connell, J., de Gascun, C., Rizzo, C., Bella, A., Alfonsi, V., Castrucci, M. R., Puzelli, S., Pagani, E., Ghisetti, V., Pariani, E., Baldanti, F., Palu, G., D'Agaro, P., Ansaldi, F., Affanni, P., Rossolini, G. M., Camilloni, B., Bagnarelli, P., Sanguinetti, Maurizio, Atripaldi, L., Chironna, M., Serra, C., Vitale, F., Germinario, C., Orsi, A., Manini, I., Montomoli, E., Napoli, C., Orsi, G. B., Casado, I., Castilla, J., Fernandino, L., Martinez-Baz, I., Ezpeleta, G., Navascues, A., Perez-Garcia, A., Aguinaga, A., Ezpeleta, C., Meijer, A., van den Brink, S., van der Hoek, W., Goderski, G., Wijsman, L., Bagheri, M., Dijkstra, F., de Lange, M., Marzec, T., Overduin, P., Teirlinck, A., Wentink, E., Donker, G., Marbus, S., van Gageldonk-Lafeber, R., Schneeberger, P., van Oosterheert, J. J., Schweitzer, V., Groeneveld, G., Nunes, B., Machado, A., Rodrigues, A. P., Gomez, V., Kislaya, I., Guiomar, R., Pechirra, P., Cristovao, P., Costa, I., Panarra, A., Corte-Real, R., Pocas, J., Peres, M. J., Comas, L. G., Marisquerena, M. E. I., Galan, J. C., Folgueira, M. D., Carril, F. G., Martinez, R. S., Cilla, G., Cenoz, M. G., Rubio, C. Q., Ochoa, E. M., Blasco, M., Duran, J. G., Vanrell, J. M., Reina, J., Castrillejo, D., Gherasim, A. M., Delgado, C., Oliva, J., Casas, I., Garcia, M., Latorre, M., Beamonte, A. M. M., Sapina, A. M., Amores, M. O., Aizpurua, A., Montes, M., Zakikhany, K., Brytting, M., Wiman, A., Carnahan, A., Warburton, F., Djennad, A., Ellis, J., Andrews, N., Marques, D., Cottrell, S., Reynolds, A., Gunson, R., Galiano, M., Lackenby, A., Robertson, C., O'Doherty, M., Sinnathamby, M., Yonova, I., Moore, C., Sartaj, M., de Lusignan, S., Zambon, M., Moren, A., Penttinen, P., Sanguinetti M. (ORCID:0000-0002-9780-7059), Rondy, M., Kissling, E., Emborg, H. -D., Gherasim, A., Pebody, R., Trebbien, R., Pozo, F., Larrauri, A., Mcmenamin, J., Valenciano, M., Kaic, B., Filipovic, S. K., Visekruna-Vucina, V., Novosel, I. P., Lovric, Z., Petrovic, G., Krause, T. G., Fische, T. K., Lina, B., Falchi, A., Vilcu, A. -M., Souty, C., Blanchon, T., van der Werf, S., Enouf, V., Behillil, S., Valette, M., Bernard-Stoecklin, S., Levy-Bruhl, D., Launay, O., Loulergue, P., Lenzi, N., Lesieur, Z., L'Honneur, A. -S., Galtier, F., Agostini, C., Serrand, C., Merle, C., Foulongne, V., Vanhems, P., Laine, F., Lagathu, G., Carrat, F., Buda, S., Preuss, U., Prahm, K., Schweiger, B., Wedde, M., Heider, A., Martin, M., Biere, B., Duerrwald, R., Domegan, L., Coughlan, L., O'Donnell, J., Joyce, M., Collins, C., Dunford, L., Moran, J., Tuite, G., Duffy, M., Connell, J., de Gascun, C., Rizzo, C., Bella, A., Alfonsi, V., Castrucci, M. R., Puzelli, S., Pagani, E., Ghisetti, V., Pariani, E., Baldanti, F., Palu, G., D'Agaro, P., Ansaldi, F., Affanni, P., Rossolini, G. M., Camilloni, B., Bagnarelli, P., Sanguinetti, Maurizio, Atripaldi, L., Chironna, M., Serra, C., Vitale, F., Germinario, C., Orsi, A., Manini, I., Montomoli, E., Napoli, C., Orsi, G. B., Casado, I., Castilla, J., Fernandino, L., Martinez-Baz, I., Ezpeleta, G., Navascues, A., Perez-Garcia, A., Aguinaga, A., Ezpeleta, C., Meijer, A., van den Brink, S., van der Hoek, W., Goderski, G., Wijsman, L., Bagheri, M., Dijkstra, F., de Lange, M., Marzec, T., Overduin, P., Teirlinck, A., Wentink, E., Donker, G., Marbus, S., van Gageldonk-Lafeber, R., Schneeberger, P., van Oosterheert, J. J., Schweitzer, V., Groeneveld, G., Nunes, B., Machado, A., Rodrigues, A. P., Gomez, V., Kislaya, I., Guiomar, R., Pechirra, P., Cristovao, P., Costa, I., Panarra, A., Corte-Real, R., Pocas, J., Peres, M. J., Comas, L. G., Marisquerena, M. E. I., Galan, J. C., Folgueira, M. D., Carril, F. G., Martinez, R. S., Cilla, G., Cenoz, M. G., Rubio, C. Q., Ochoa, E. M., Blasco, M., Duran, J. G., Vanrell, J. M., Reina, J., Castrillejo, D., Gherasim, A. M., Delgado, C., Oliva, J., Casas, I., Garcia, M., Latorre, M., Beamonte, A. M. M., Sapina, A. M., Amores, M. O., Aizpurua, A., Montes, M., Zakikhany, K., Brytting, M., Wiman, A., Carnahan, A., Warburton, F., Djennad, A., Ellis, J., Andrews, N., Marques, D., Cottrell, S., Reynolds, A., Gunson, R., Galiano, M., Lackenby, A., Robertson, C., O'Doherty, M., Sinnathamby, M., Yonova, I., Moore, C., Sartaj, M., de Lusignan, S., Zambon, M., Moren, A., Penttinen, P., and Sanguinetti M. (ORCID:0000-0002-9780-7059)

Abstract

Between September 2017 and February 2018, influenza A(H1N1)pdm09, A(H3N2) and B viruses (mainly B/Yamagata, not included in 2017/18 trivalent vaccines) co-circulated in Europe. Interim results from five European studies indicate that, in all age groups, 2017/18 influenza vaccine effectiveness was 25 to 52% against any influenza, 55 to 68% against influenza A(H1N1)pdm09, -42 to 7% against influenza A(H3N2) and 36 to 54% against influenza B. 2017/18 influenza vaccine should be promoted where influenza still circulates.

Published
2018

29. Low 2016/17 season vaccine effectiveness against hospitalised influenza A(H3N2) among elderly: awareness warranted for 2017/18 season

Author

Rondy, M., Gherasim, A., Casado, I., Launay, O., Rizzo, C., Pitigoi, D., Mickiene, A., Marbus, S. D., Machado, A., Syrjanen, R. K., Pem-Novose, I., Horvath, J. K., Larrauri, A., Castilla, J., Vanhems, P., Alfonsi, V., Ivanciuc, A. E., Kuliese, M., Van Gageldonk-Lafeber, R., Gomez, V., Ikonen, N., Lovric, Z., Ferenczi, A., Moren, A., Pozo, F., Garcia, M., Latorre, M., Omenaca, M., Oribe Amores, M., Munoz, N., Cilla, G., Fernandino, L., Martinez-Baz, I., Navascues, A., Perez-Garcia, A., Aguinaga, A., Ezpeleta, C., Bella, A., Appelgren, E. C., Castrucci, M. R., Puzelli, S., Chironna, M., Germinario, C., Ansaldi, F., Manini, I., Montomoli, E., Lupulescu, E., Lazar, M., Mihai, M. E., Cherciu, C. M., Dinu, S., Tecu, C., Nitescu, M., Bacruban, R., Azamfire, D., Dumitrescu, A., Ianosik, E., Ceausu, E., Popescu, C. P., Florescu, S. A., Tardei, G., Bejan, C., Teodor, A., Juganariu, G., Plesca, C., Duca, E., Lenzi, N., Lesieur, Z., Loulergue, P., Galtier, F., Agostini, C., Ray, M., Merle, C., Foulongne, V., Lina, B., Laine, F., De Guibert, S., Lagathu, G., Tattevin, P., Jouneau, S., Esvant, A., Le Gallou, T., Carrat, F., Mawuvi, G., Chau, F., Nohynek, H., Haveri, A., Gefenaite, G., Velyvyte, D., Jancoriene, L., Zablockiene, B., Ambrozaitis, A., Grimalauskaite, R., Damuleviciene, G., Lesauskaite, V., Bagdonas, A., Nunes, B., Kislaya, I., Rodrigues, A. P., Gomes, V., Corte-Real, R., Pocas, J., Peres, M. J., Bernard, K., Kurecic-Filipovic, S., Visekruna Vucina, V., Topic, A., Papic, N., Budimir, J., Oroszi, B., Meijer, A., Van Der Hoek, W., Schneeberger, P. M., EpiConcept [Paris], Institute of Health 'Carlos III', CIBER de Epidemiología y Salud Pública (CIBERESP), IDISNA, Pamplona, CIC Cochin Pasteur (CIC 1417), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu-Université Paris Descartes - Paris 5 (UPD5)-Groupe hospitalier Broca-Institut National de la Santé et de la Recherche Médicale (INSERM), F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC), Istituto Superiore di Sanità (ISS), University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Lithuanian University of health Sciences, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal] (INSA), National Institute for Health and Welfare [Helsinki], Croatian Institute of Public Health [Zagreb] (CIPH), Office of the Chief Medical Officer, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory (LPE-Fondation Mérieux), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institute of Biology Bucharest of Romanian Academy, Epidemiology Department, Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe hospitalier Broca-Université Paris Descartes - Paris 5 (UPD5)-Hôtel-Dieu-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Istituto Superiore di Sanità Rome, Rome, Italy, Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), EpiConcept, Unión Europea, CIC Cochin Pasteur ( CIC 1417 ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP]-Hôtel-Dieu-Groupe hospitalier Broca-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Descartes - Paris 5 ( UPD5 ), F-CRIN, I-REIVAC, Institut National de la Santé et de la Recherche Médicale ( INSERM ), National Center for Epidemiology Surveillance and Health Promotion, Istituto Superiore di Sanita [Rome], 'Carol Davila' University of Medicine and Pharmacy, National Institute for Public Health and the Environment [Bilthoven] ( RIVM ), Instituto Nacional de Saúde Doutor Ricardo Jorge, Croatian Institute of Public Health, Zagreb, Hospices Civils de Lyon ( HCL ), Centre International de Recherche en Infectiologie ( CIRI ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-École normale supérieure - Lyon ( ENS Lyon ), Istituto Superiore de Sanita, HAL-UPMC, Gestionnaire, École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, 0301 basic medicine, Pediatrics, Epidemiology, Efetividade da Vacina Antigripal, A(H3N2), Influenza, cases control, elderly, hospitalisation, vaccine effectiveness, Elderly, 0302 clinical medicine, vaccine, Outcome Assessment, Health Care, Influenza A Virus, Hospitalisation, awareness, 030212 general & internal medicine, media_common, Vaccine effectiveness, virus diseases, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Middle Aged, Hospitals, 3. Good health, Hospitalization, Influenza Vaccines, H3N2 Subtype, Female, Seasons, influenza, Rapid Communication, Human, Adult, medicine.medical_specialty, Adolescent, Influenza vaccine, 030106 microbiology, Outcome Assessment (Health Care), 03 medical and health sciences, [SDV.IMM.VAC] Life Sciences [q-bio]/Immunology/Vaccinology, Virology, Influenza, Human, medicine, Aged, European Union, Humans, Influenza A Virus, H3N2 Subtype, media_common.cataloged_instance, Vacina Antigripal, European union, Cases control, Cases Control, business.industry, Public health, Cuidados de Saúde, Public Health, Environmental and Occupational Health, Case-control study, Influenza a, Confidence interval, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Emergency medicine, [ SDV.IMM.VAC ] Life Sciences [q-bio]/Immunology/Vaccinology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology, Prevention control, business
Abstract

Members of the I-Move+hospital working group - Portugal: B. Nunes, I. Kislaya, A.P. Rodrigues (National Health Institute Doutor Ricardo Jorge, Lisbon), V. Gomes, R. Côrte-Real (Centro Hospitalar de Lisboa Central, Lisbon), J. Poças, M.J. Peres (Centro Hospitalar de Setúbal, Setúbal). In a multicentre European hospital study we measured influenza vaccine effectiveness (IVE) against A(H3N2) in 2016/17. Adjusted IVE was 17% (95% confidence interval (CI): 1 to 31) overall; 25% (95% CI: 2 to 43) among 65-79-year-olds and 13% (95% CI: -15 to 30) among those ≥ 80 years. As the A(H3N2) vaccine component has not changed for 2017/18, physicians and public health experts should be aware that IVE could be low where A(H3N2) viruses predominate. Funding: The I-MOVE+ project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 634446. The Lithuanian I-MOVE+ study sites were supported by a grant from the Research Council of Lithuania (SEN-03/2015). info:eu-repo/semantics/publishedVersion

Published
2017

30. Repeated seasonal influenza vaccination among elderly in Europe: Effects on laboratory confirmed hospitalised influenza

Author

Rondy, M., Launay, O., Castilla, J., Costanzo, S., Puig-Barbera, J., Gefenaite, G., Larrauri, A., Rizzo, C., Pitigoi, D., Syrjanen, R. K., Machado, A., Filipovic, S. K., Horvath, J. K., Paradowska-Stankiewicz, I., Marbus, S., Moren, A., Valenciano, M., Lenzi, N., Lesieur, Z., Loulergue, P., Galtier, F., Ray, M., Foulongne, V., Letois, F., Merle, C., Vanhems, P., Lina, B., Casado, I., Diaz-Gonzalez, J., Guevara, M., Martinez-Baz, I., Fernandino, L., Navascues, A., Ezpeleta, C., Chamorro, J., Barrado, L., Ortega, M. T., De Gaetano Donati, K., Cauda, R., Donato, C., Taccari, F., Campana, L., Santangelo, R., Perlasca, F., Fichera, G., Dara, M., Iacoviello, L., Olivieri, M., Alfonsi, V., Bella, A., Puzelli, S., Castrucci, M. R., Orsi, A., Ansaldi, F., Manini, I., Montomoli, E., Chironna, M., Germinario, C., Diez-Domingo, J., Sanudo, B., Carratala Munuera, C., Correcher Medina, P., Gil Guillen, V., Larrea Gonzalez, R., Limon Ramirez, R., Mico Esparza, J. L., Mollar Maseres, J., Otero Reigada, M. C., Tortajada Girbes, M., Schwarz Chavarri, G., Ambrozaitis, A., Jancoriene, L., Zablockiene, B., Zagminas, K., Aukse, M., Damuleviciene, G., Grimalauskaite, R., Kuliese, M., Lesauskaite, V., Velyvyte, D., Niesters, H., Stolk, R. P., Zagmines, K., Rahamat-Langendoen, J., Gherasim, A., Pozo, F., Altzibar, J., Arraras, J. G., Cilla, G., Marco, E., Vidal Garcia, M., Omenaca, M., Ivanciuc, A. E., Lupulescu, E., Lazar, M., Cherciu, C. M., Tecu, C., Mihai, M. E., Nitescu, M., Leca, D., Ceausu, E., Nohynek, H., Ikonen, N., Haveri, A., Gomez, V., Nunes, B., Rodrigues, A. P., Gomes, V., Corte-Real, R., Pocas, J., Peres, M. J., Visekruna Vucina, V., Kaic, B., Novosel, I. P., Petrovic, G., Ferenczi, A., Oroszi, B., Korczynska, M. R., Brydak, L. B., Cieslik-Tarkota, R., Rozwadowska, B., Skolimowska, G., Hulboj, D., Jakubik, A., Meijer, A., Van Gageldonk-Lafeber, A. B., Research Council of Lithuania, and European Union

Subjects
0301 basic medicine, Male, Veterinary medicine, Immunology and Microbiology (all), medicine.disease_cause, Polymerase Chain Reaction, Aged, Aged, 80 and over, Case-Control Studies, Clinical Laboratory Techniques, Europe, Female, Hospitalization, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza B virus, Influenza Vaccines, Influenza, Human, Respiratory Tract Infections, Seasons, Sentinel Surveillance, Vaccination, Molecular Medicine, Veterinary (all), Public Health, Environmental and Occupational Health, Infectious Diseases, Seasonal influenza, IMOVE+, 0302 clinical medicine, 80 and over, Influenza A Virus, Influenza A virus, 030212 general & internal medicine, Respiratory tract infections, virus diseases, 3. Good health, H3N2 Subtype, Public Health, Human, medicine.medical_specialty, Influenza vaccine, 030106 microbiology, Virus, Hospital, 03 medical and health sciences, Repeated Vaccination, Internal medicine, medicine, H1N1 Subtype, Influenza Vaccine Effectiveness, General Veterinary, General Immunology and Microbiology, business.industry, Environmental and Occupational Health, Cuidados de Saúde, Case-control study, Influenza, Negative case, influenza vaccination, test negative case control, vaccine effectiveness, business
Abstract

In Europe, annual influenza vaccination is recommended to elderly. From 2011 to 2014 and in 2015-16, we conducted a multicentre test negative case control study in hospitals of 11 European countries to measure influenza vaccine effectiveness (IVE) against laboratory confirmed hospitalised influenza among people aged ≥65years. We pooled four seasons data to measure IVE by past exposures to influenza vaccination. We swabbed patients admitted for clinical conditions related to influenza with onset of severe acute respiratory infection ≤7days before admission. Cases were patients RT-PCR positive for influenza virus and controls those negative for any influenza virus. We documented seasonal vaccination status for the current season and the two previous seasons. We recruited 5295 patients over the four seasons, including 465A(H1N1)pdm09, 642A(H3N2), 278 B case-patients and 3910 controls. Among patients unvaccinated in both previous two seasons, current seasonal IVE (pooled across seasons) was 30% (95%CI: -35 to 64), 8% (95%CI: -94 to 56) and 33% (95%CI: -43 to 68) against influenza A(H1N1)pdm09, A(H3N2) and B respectively. Among patients vaccinated in both previous seasons, current seasonal IVE (pooled across seasons) was -1% (95%CI: -80 to 43), 37% (95%CI: 7-57) and 43% (95%CI: 1-68) against influenza A(H1N1)pdm09, A(H3N2) and B respectively. Our results suggest that, regardless of patients' recent vaccination history, current seasonal vaccine conferred some protection to vaccinated patients against hospitalisation with influenza A(H3N2) and B. Vaccination of patients already vaccinated in both the past two seasons did not seem to be effective against A(H1N1)pdm09. To better understand the effect of repeated vaccination, engaging in large cohort studies documenting exposures to vaccine and natural infection is needed. The Lithuanian I-MOVE+ study sites were supported by a grant from the Research Council of Lithuania (SEN-03/2015). The IMOVE+ project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 634446. GlaxoSmithKline, Sanofi Pasteur and Sanofi Pasteur MSD financially supported the InNHOVE network. They had no role in study design, data collection, pooled analysis, and publication. We are grateful to all patients, medical staff, study nurses and epidemiologists from the twelve study sites who actively participated in the study. info:eu-repo/semantics/publishedVersion

Published
2017

31. 2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project

Author

Rondy, Marc, Larrauri, A., Casado, I., Alfonsi, V., Pitigoi, D., Launay, O., Syrjänen, R. K., Gefenaite, G., Machado, A., Vučina, V. V., Horváth, J. K., Paradowska-Stankiewicz, I., Marbus, S. D., Gherasim, A., Díaz-González, J. A., Rizzo, C., Ivanciuc, A. E., Galtier, F., Ikonen, N., Mickiene, A., Gomez, V., Kurečić Filipović, S., Ferenczi, A., Korcinska, M. R., Van Gageldonk-Lafeber, R., Valenciano, M., Altzibar, Jone M., Arraras, Ion Garcia, Cilla, Gustavo, Marco, Elisa, Vidal, Matxalen, Omenaca, Manuel, Castilla, J., Navascues, A., Ezpeleta, C., Barrado, L., Ortega, M. T., Bella, A., Castrucci, M. R., Puzelli, S., Chironna, M., Germinario, C., Ansaldi, F., Orsi, A., Manini, I., Montomoli, E., Lupulescu, E., Lazar, M., Cherciu, C. M., Tecu, C., Mihai, M. E., Nitescu, M., Leca, D., Ceausu, E., Lenzi, N., Lesieur, Z., Loulergue, P., Foulongne, V., Letois, F., Merle, C., Vanhems, P., Lina, B., Nohynek, H., Haveri, A., Kuliese, M., Velyvyte, D., Grimalauskaite, R., Damuleviciene, G., Lesauskaite, V., Jancoriene, L., Zablockiene, B., Ambrozaitis, A., Nunes, B., Rodrigues, A. P., Gomes, V., Corte-Real, R., Pocas, J., Peres, M. J., Kaić, B., Oroszi, B., Brydak, L. B., Cieślak, K., Kowalczyk, D., Szymański, K., Jakubik, A., Skolimowska, G., Hulboj, D., Meijer, A., Van Der Hoek, W., Schneeberger, P. M., Palmieri, Annapina, Giannitelli, Stefania, Ranghiasci, Alessia, Bacruban, Rodica, Azamfire, Delia, Dumitrescu, Aura, Ianosik, Elena, Duca, Elena, Bejan, Codrina, Teodor, Andra, Florescu, Simin-Aysel, Popescu, Corneliu, Tardei, Gratiela, Charpentier, Julien, Marin, Nathalie, Doumenc, Benoit, Le Jeunne, Claire, Krivine, Anne, Momcilovic, Sonia, Benet, Thomas, Amour, Selilah, Henaff, Laetitia, Jokinen, Jukka, Lyytikainen, Outi, Palmu, Arto, Siren, Paivi, Ruokokoski, Esa, Nunes, Baltazar, Rodrigues, Ana Paula, Guiomar, Raquel, Gomes, Victor, Quaresma, Filipa, Vale, Luis, Garcia, Teresa, Bernardo, Teresa, Dias, Liliana, Fonseca, Paula, Amorim, Helena, Rolo, Joao, Pacheco, Helena, Branquinho, Paula, Corte-Real, Rita, Pocas, Jose, Lopes, Paula, Peres, Maria Joao, Ribeiro, Rosa, Duarte, Paula, Pedroso, Ermelinda, Rodrigues, Sara, Silverio, Ana Rita, Pedreira, Diana Gomes, Fonseca, Marta Ferreira, Vince, Adriana, Topić, Antea, Papić, Neven, Mihalić, Jelena Budimir, Novosel, Iva Pem, Petrović, Goranka, Zajec, Martina, Draženović, Vladimir, Hercegh, Eva, Szalai, Balint, Antmann, Katalin, Nagy, Kamilla, Unión Europea, EpiConcept, Institute of Health Carlos III, CIBER de Epidemiología y Salud Pública (CIBERESP), Istituto Superiore de Sanita, University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal] (INSA), CIC Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-CHU Saint-Eloi-Institut National de la Santé et de la Recherche Médicale (INSERM), F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC), Institut National de la Santé et de la Recherche Médicale (INSERM), National Institute for Health and Welfare [Helsinki], and National Institute for Public Health and the Environment [Bilthoven] (RIVM)

Subjects
Infecções Respiratórias, 0301 basic medicine, Male, Heart disease, Epidemiology, Efetividade da Vacina Antigripal, 0302 clinical medicine, Influenza A Virus, H1N1 Subtype, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Outcome Assessment, Health Care, 80 and over, Influenza A Virus, Medicine, 030212 general & internal medicine, Aged, 80 and over, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, Vaccination, virus diseases, 3. Good health, Europe, Hospitalization, Influenza Vaccines, case control, elderly, hospitalisation, influenza, severe acute respiratory infection, vaccine effectiveness, vaccine-preventable diseases, Vaccine-preventable diseases, Female, Public Health, Seasons, Research Article, Human, medicine.medical_specialty, Influenza vaccine, 030106 microbiology, Aged, Humans, Influenza B virus, Influenza, Human, Logistic Models, Outcome Assessment (Health Care), Sentinel Surveillance, Vaccine Potency, Public Health, Environmental and Occupational Health, Virology, Hospital, 03 medical and health sciences, Diabetes mellitus, Internal medicine, H1N1 Subtype, Vacina Antigripal, Intensive care medicine, business.industry, Environmental and Occupational Health, Cuidados de Saúde, Case-control study, medicine.disease, Influenza, Confidence interval, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology, business
Abstract

Members of the I-MOVE+ project - Portugal: Baltazar Nunes, Ana Paula Rodrigues, Raquel Guiomar (Infectious Diseases Department, National Health Institute Doutor Ricardo Jorge, Lisbon, Portugal), Victor Gomes, Filipa Quaresma, Luis Vale, Teresa Garcia, Teresa Bernardo, Liliana Dias, Paula Fonseca, Helena Amorim, João Rolo, Helena Pacheco, Paula Branquinho, Rita Côrte-Real (Centro Hospitalar de Lisboa Central, Lisbon, Portugal),José Poças, Paula Lopes, Maria João Peres, Rosa Ribeiro, Paula Duarte, Ermelinda Pedroso, Sara Rodrigues, Ana Rita Silvério, Diana Gomes Pedreira, Marta Ferreira Fonseca, (Centro Hospitalar de Setúbal, Setúbal, Portugal). We conducted a multicentre test-negative case-control study in 27 hospitals of 11 European countries to measure 2015/16 influenza vaccine effectiveness (IVE) against hospitalised influenza A(H1N1)pdm09 and B among people aged ≥ 65 years. Patients swabbed within 7 days after onset of symptoms compatible with severe acute respiratory infection were included. Information on demographics, vaccination and underlying conditions was collected. Using logistic regression, we measured IVE adjusted for potential confounders. We included 355 influenza A(H1N1)pdm09 cases, 110 influenza B cases, and 1,274 controls. Adjusted IVE against influenza A(H1N1)pdm09 was 42% (95% confidence interval (CI): 22 to 57). It was 59% (95% CI: 23 to 78), 48% (95% CI: 5 to 71), 43% (95% CI: 8 to 65) and 39% (95% CI: 7 to 60) in patients with diabetes mellitus, cancer, lung and heart disease, respectively. Adjusted IVE against influenza B was 52% (95% CI: 24 to 70). It was 62% (95% CI: 5 to 85), 60% (95% CI: 18 to 80) and 36% (95% CI: -23 to 67) in patients with diabetes mellitus, lung and heart disease, respectively. 2015/16 IVE estimates against hospitalised influenza in elderly people was moderate against influenza A(H1N1)pdm09 and B, including among those with diabetes mellitus, cancer, lung or heart diseases. The I-MOVE+ project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 634446. info:eu-repo/semantics/publishedVersion

Published
2017

32. Thin walled pottery from Alife (Northern Campania, Italy)

Author

Grifa, C, De Bonis, A, Guarino, V, Petrone, CM, Germinario, C, Mercurio, M, Soricelli, G, Langella, A, Morra, V, Grifa, C., DE BONIS, Alberto, Guarino, Vincenza, Petrone, C. M., Germinario, C., Mercurio, M., Soricelli, G., Langella, A., and Morra, Vincenzo

Subjects
Thin walled pottery, Alife, Volturno river clays, Grain Size Analyses, levigation, Thin walled pottery, Alife, Volturno river clays, Grain Size Analyses, levigation, Volturno river clay, Grain Size analyse
Abstract

The ancient town of Allifae (modern Alife) represents one of the most interesting settlements of the Northern Campania area that, together with the ancient city of Cales, was a thriving production centre of pottery. Excavations carried out inside the city wall, near the south gate, the so-called Porta Fiume, unearthed a huge dump of thin walled ware where the most abundant forms were cups and beakers, decorated with grooves or rouletting. The dump has been dated Augustan/ early Tiberian age (20 b.C.- 20 AD) and the thin walled vessels found can be identified with similar wares from Allifae, Cubulteria, Caiatia and perhaps Neapolis. Horace in his Sermones (II, 8,39) cited the Allifana beakers (described as fictiles ac subtiles by a Horace scholiast) and they could possibly be identified with the thin walled wares produced in Allifae. If this the case, then the thin walled vessels produced in Allifae were known in Rome as early as the end of I century B.C. In order to investigate and characterise the Allifae thin-walled pottery, twenty-one samples were selected and mineralogical-petrographic analyses (OM, XRPD, XRF and SEM/EDS) were carried out. The clayey raw material used was a low-CaO alluvial clayey deposit from the Middle Valley of the Volturno River. The potters probably handled the sediment by a levigation process in order to remove the coarser grains, and making the clay suitable to produce such thin walls. Comparison with other regional production of thin-walled pottery allowed us to strictly distinguish the Allifana beakers.

Published
2015

33. Results of diagnostic campaign promoted by AIAr in the deposits of the Archaeological Museum of Paestum

Author

Oddo, M. E, primary, Ricci, P., additional, Angelici, D., additional, Fantino, F., additional, Sibilia, E., additional, Alberghina, M. F, additional, Schiavone, S., additional, Grifa, C., additional, Mercurio, M., additional, Germinario, C., additional, Izzo, F., additional, Langella, A., additional, Massa, E., additional, Bracci, S., additional, Magrini, D., additional, Costa, R., additional, Pelagotti, A., additional, Zuchtriegel, G., additional, and Lubritto, C., additional

Published
2018
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34. Thin walled pottery from Alife (Northern Campania, Italy)

Author

Grifa, C, De Bonis, A, Guarino, V, Petrone, CM, Germinario, C, Mercurio, M, Soricelli, G, Langella, A, Morra, V, Grifa, C, De Bonis, A, Guarino, V, Petrone, CM, Germinario, C, Mercurio, M, Soricelli, G, Langella, A, and Morra, V

Abstract

The file attached is the published version of the article., NHM Repository

Published
2017

37. Molecular characterization of rotavirus strains from children with diarrhea in Italy, 2007-2009

Author

Ruggeri, Fm, Delogu, R, Petouchoff, T, Tcheremenskaia, O, De Petris, S, Fiore, L, RotaNet Italy Study Group: Pompa MG, Francesca, R, Zanella, F, Cesco, D, Sartore, P, Micera, M, Zotti, Carla Maria, Cacello, E, Balbi, L, Barbi, M, Binda, S, Primache, V, Iorio, Am, Camilloni, B, Basileo, M, Medici, Mc, Chezzi, C, Abelli, L, Rizzo, C, Giammanco, Gm, De Grazia, S, Angela, M, Chironna, M, Sallustio, A, Germinario, C, Tanzi, Ml, Pietrosemoli, P, D'Errico, M, Marigliano, A, Comodo, N, Lorini, C, Martella, V, Storelli, S, Cocchi, P, Festini, F, De Rosa, M, Chisari, M, Raglio, A, Zanchi, A, Onori, M, Danzi, G, Lazzarotto, T, Pedroni, M, Mignacca, A, Ansaldi, F, Mammì, P, Calabria, R., Ruggeri F.M., Delogu R., Petouchoff T., Tcheremenskaia O., De Petris S., Fiore L., Pompa M.G., Russo F., Zanella F., Cesco D., Sartore P., Micera M., Zotti C., Cacello E., Balbi L., Barbi M., Binda S., Primache V., Iorio A.M., Camilloni B., Basileo M., Medici M.C., Chezzi C., Abelli L., Rizzo C., Giammanco G.M., De Grazia S., Platia M.A., Chironna M., Sallustio A., Germinario C., Tanzi M.L., Pietrosemoli P., D'Errico M., Marigliano A., Comodo N., Lorini C., Martella V., Storelli S., Cocchi P., Festini F., De Rosa M., Chisari M., Raglio A., Zanchi A., Onori M., Danzi G., Lazzarotto T., Pedroni M., Mignacca A., Ansaldi F., Mammi P., Tcheremenskia O., De Pretis S., and RotaNet-Italy Study group.

Subjects
Diarrhea, Rotavirus, Genotyping, Settore MED/07 - Microbiologia E Microbiologia Clinica, viruses, genotype, Reassortment, Biology, medicine.disease_cause, Polymerase Chain Reaction, Rotavirus Infections, law.invention, strain, law, Virology, Genotype, Genetic variation, medicine, Humans, Polymerase chain reaction, Base Sequence, Molecular epidemiology, Infant, Newborn, Rotavirus Vaccines, Genetic Variation, Infant, Sequence Analysis, DNA, Rotaviru, Infectious Diseases, Italy, Child, Preschool, surveillance, RNA, Viral, medicine.symptom, Reassortant Viruses
Abstract

The surveillance network RotaNet-Italia was established in 2007 in order to investigate the diversity of co-circulating rotavirus strains in Italy, and to provide a baseline for future assessment of possible effects of vaccine implementation in selecting novel versus common rotavirus strains. A total of 2,645 rotavirus strains from pediatric patients with acute diarrhea were collected over three consecutive seasons from September 2006 through August 2009, and partially characterized by standardized multiplex RT-PCR. Most of strains (89.1%) belonged to genotypes G1–G4, and G9, associated with either P[8] or P[4], commonly found in humans worldwide. However, in at least 2.0% of cases, viruses exhibited either a G or P type typical of animal viral strains, suggesting gene reassortment events between rotaviruses of different origin. Mixed infections with two or more rotavirus strains were observed frequently (7.6% of patients), and depended on the frequencies of co-circulating rotaviruses of one particular genotype. The numbers and genotypes of likely natural reassortants of common genotype rotaviruses were found to be correlated with the observed numbers and genotypes of mixed infections. Large variation in the relative frequency of different rotavirus genotypes was observed between different seasons and/or areas of Italy, suggesting independent evolution or differential introduction of viral strains with respect to both time and space. J. Med. Virol. 83:1657–1668

Published
2011

38. Sorveglianza dell'influenza nella stagione 2005/2006 in Puglia

Author

QUATTROCCHI, MANUELA, CAMPA, ANNAMARIA, GUIDO, Marcello, DE DONNO, Maria Antonella, PASANISI G, ROLLO M. C, LOBREGLIO G, GERMINARIO C, ANSALDI F, GRUPPO COLLABORATIVO PER LA SORVEGLIANZA DELL'INFLUENZA, Quattrocchi, Manuela, Pasanisi, G, ROLLO M., C, Lobreglio, G, Campa, Annamaria, Germinario, C, Ansaldi, F, Guido, Marcello, DE DONNO, Maria Antonella, and GRUPPO COLLABORATIVO PER LA SORVEGLIANZA, Dell'Influenza

Subjects
Influenza
Published
2006

40. Sorveglianza dell'influenza in Puglia nella stagione 2004-2005

Author

QUATTROCCHI, MANUELA, GUIDO, Marcello, DE DONNO, Maria Antonella, GERMINARIO C, PRATO R, ANSALDI F, STICCHI L, GABUTTI G, GRUPPO COLLABORATIVO DI SORVEGLIANZA DELL'INFLUENZA, Società Italiana di Igiene, Medicina Preventiva e Sanità Pubblica, Quattrocchi, Manuela, Guido, Marcello, DE DONNO, Maria Antonella, Germinario, C, Prato, R, Ansaldi, F, Sticchi, L, Gabutti, G, and GRUPPO COLLABORATIVO DI SORVEGLIANZA, Dell'Influenza

Subjects
Puglia, sorveglianza virologica, influenza, Sorveglianza epidemiologica
Published
2005

42. Surveillance of influenza in Apulia, Italy, 1999-2000, 2000-2001, 2001-2002 et 2002-2003 seasons

Author

GABUTTI G, ZIZZA A, GASPARINI R, DONATELLI I, PRATO R, GERMINARIO C, CROVARI P., GUIDO, Marcello, QUATTROCCHI, MANUELA, DE DONNO, Maria Antonella, Gabutti, G, Guido, Marcello, Quattrocchi, Manuela, Zizza, A, DE DONNO, Maria Antonella, Gasparini, R, Donatelli, I, Prato, R, Germinario, C, and Crovari, P.

Subjects
Epidemiological surveillance, Vaccination, Influenza, respiratory tract diseases, Virological surveillance
Abstract

BACKGROUND: The objective of this study was to evaluate, within the Italian National Influenza Epidemiological and Virological Surveillance, the rate of vaccination coverage, the incidence of Influenza Like-Illness (ILI), the incidence of Acute Respiratory Illness (ARI), and to identify the virus strains circulating in Apulia from 1999 to 2003. METHODS: Vaccination coverage rates were calculated based on the number of doses administered to individuals > 65 years of age. Every week, sentinel physicians reported ILI and ARI cases having occurred among their patients. Voluntary general practitioners (GPs) and paediatricians (Ps) collected oropharyngeal swab samples from patients suspected with ILI. Influenza viruses were isolated and identified by cell culture (MDCK cells) and RT-PCR. Virological surveillance was carried out by the ISS, in collaboration with a network of peripheral laboratories. RESULTS: In Apulia, vaccination coverage progressively increased to 68.6% during the 2002-2003 season. The analysis of ILI cases showed higher incidence rates during the 1999-2000 and 2002-2003 seasons. ARI rates appeared to have a more constant trend. ILI and ARI incidence rates were higher in the 0-14 year age group. CONCLUSION: The increase in vaccination coverage rates and implementation of the network of clinical, and epidemiological and virological surveillance are fundamental for the control and prevention of influenza

Published
2004

44. SURVEILLANCE OF INFLUENZA IN APULIA, ITALY, IN THE 1999-2000, 2000-2001 AND 2001-2002 INFLUENZA SEASONS

Author

ZIZZA A, QUATTROCCHI M, LAI P, MORELLI P, PRATO R, GERMINARIO C, GABUTTI G, AND THE COLLABORATIVE GROUP FOR THE STUDY OF INFECTIOUS DISEASES AND THE COLLABORATIVE GROUP FOR INFLUEZA SURVEILLANCE, GUIDO, Marcello, DE DONNO, Maria Antonella, Zizza, A, Guido, Marcello, Quattrocchi, M, DE DONNO, Maria Antonella, Lai, P, Morelli, P, Prato, R, Germinario, C, Gabutti, G, and AND THE COLLABORATIVE GROUP FOR THE STUDY OF INFECTIOUS DISEASES AND THE COLLABORATIVE GROUP FOR INFLUEZA, Surveillance

Published
2003

45. SIEROPREVALENZA ANTI-HEV IN PROVINCIA DI LECCE

Author

DE DONNO, Maria Antonella, GUIDO, Marcello, CHIRONNA M, CRACA R, PAIANO A, ZIZZA A, CARROZZINI F, GERMINARIO C, GABUTTI G., DE DONNO, Maria Antonella, Chironna, M, Craca, R, Paiano, A, Zizza, A, Guido, Marcello, Carrozzini, F, Germinario, C, and Gabutti, G.

Published
2003

46. Prevalenza di anticorpi anti-HEV nella Provincia di Lecce

Author

GUIDO, Marcello, DE DONNO, Maria Antonella, CHIRONNA M, CRACA R, PAIANO A, ZIZZA A, CARROZZINI F, GERMINARIO C, GABUTTI G., Guido, Marcello, Chironna, M, Craca, R, Paiano, A, Zizza, A, DE DONNO, Maria Antonella, Carrozzini, F, Germinario, C, and Gabutti, G.

Published
2002

48. Prevalenza di anticorpi ANTI-HEV in provincia di Lecce

Author

Guido, M., Chironna, M., Craca, R., Paiano, A., Zizza, A., De Donno, A., Carrozzini, F., Germinario, C., Gabutti, Giovanni, Guido, Marcello, Chironna, M, Craca, R, Paiano, A, Zizza, A, DE DONNO, Maria Antonella, Carrozzini, F, Germinario, C, and Gabutti, G.

Published
2002

49. Sorveglianza epidemiologica e virologica dell’infezione da virus influenzali nella Provincia di Lecce: stagione 2000/2001

Author

DE DONNO, Maria Antonella, CIANNAMEA B., LEO G., FEDELE A., ROLLO R., DURANDO P., GERMINARIO C., LOPALCO P.L., GABUTTI G., Gruppo Collaborativo per la Sorveglianza dell'influenza, GUIDO, Marcello, DE DONNO, Maria Antonella, Ciannamea, B., Leo, G., Fedele, A., Rollo, R., Durando, P., Germinario, C., Lopalco, P. L., Gabutti, G., Gruppo Collaborativo per la Sorveglianza, Dell'Influenza, and Guido, Marcello

Subjects
PCR, Virological/epidemiological surveillance, Vaccination, virus diseases, Influenza
Abstract

Influenza is an important public problem in relation to the considerable epidemiological impact in terms of morbidity and mortality. Surveillance is therefore central to monitor the spread of this infection in the population of a specific area. For these reasons, virological, clinical and epidemiological surveillance were conducted during the 2000/2001 influenza season in the area of Lecce. The surveillance activities were part of a national influenza surveillance programme. A team of sentinel physicians, voluntary general practitioners and pediatricians, monitored a sample of 1% of the total population. These doctors reported weekly the number of patients with influenza-like illness (ILI) or acute respiratory illness (ARI), indicating if these patients had or had not received influenza vaccine. In parallel with the clinical and epidemiological surveillance, virological surveillance was also carried out in a group of patients meeting the ILI criteria. Samples of nasal and pharyngeal secretions were collected from these patients in order to isolate and identify any influenza viruses. The epidemiological surveillance showed that most of the patients affected by influenza were young subjects aged up to 14 years and adults aged 15-64 years. They were mostly non-vaccinated subjects. The average rate of incidence for the 2000/2001 season was 3.03/1,000 inhabitants. Virological surveillance evidenced that during the 2000/2001 influenza season all cases were associated to the A/H1N1 virus.

Published
2002

50. SORVEGLIANZA EPIDEMIOLOGICA E VIROLOGICA DELL'INFEZIONE DA VIRUS INFLUENZALI NELLA PROVINCIA DI LECCE : STAGIONE 2000-2001

Author

DE DONNO, Maria Antonella, CIANNAMEA B, LEO G, FEDELE A, ROLLO R, DURANDO P, GERMINARIO C, LOPALCO PL, GABUTTI G. E. GRUPPO COLLABORATIVO PER LA SORVEGLIANZA DELL' INFLUENZA, DE DONNO, Maria Antonella, Ciannamea, B, Leo, G, Fedele, A, Rollo, R, Durando, P, Germinario, C, Lopalco, Pl, and GABUTTI G. E., GRUPPO COLLABORATIVO PER LA SORVEGLIANZA DELL' INFLUENZA

Abstract

Influenza is an important public health problem in relation to the considerable epidemiological impact in terms of morbidity and mortality. Surveillance is therefore central to monitor the spread of this infection in the population of a specific area. For these reasons, virological, clinical and epidemiological surveillance were conducted during the 2000/2001 influenza season in the area of Lecce. The surveillance activities were part of a national influenza surveillance programme. A team of sentinel physicians, voluntary general practitioners and paediatricians, monitored a sample of 1% of the total population. These doctors reported weekly the number of patients with influenza-like illness (ILI) or acute respiratory illness (ARI), indicating if these patients had or had not received influenza vaccine. In parallel with the clinical and epidemiological surveillance, virological surveillance was also carried out in a group of patients meeting the ILI criteria. Samples of nasal and pharyngeal secretions were collected from these patients in order to isolate and identify any influenza viruses. The epidemiological surveillance showed that most of the patients affected by influenza were young subjects aged up to 14 years and adults aged 15-64 years. They were mostly non-vaccinated subjects. The average rate of incidence for the 2000/2001 season was 3.03/1000 inhabitants. Virological surveillance evidenced that during the 2000/2001 influenza season all cases were associated to the A/H I N 1 virus.

Published
2002

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