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18 results on '"Germic, Nina"'

1. A MULTICENTER LONG-TERM COHORT STUDY OF EOSINOPHILIC ESOPHAGITIS VARIANTS AND THEIR PROGRESSION TO EOE OVER TIME

Author

Greuter, Thomas, Straumann, Alex, Fernandez-Marrero, Yuniel, Germic, Nina, Hosseini, Aref, Chanwangpong, Apinya, Yousefi, Shida, Simon, Dagmar, Collins, Margaret H., Bussmann, Christian, Chehade, Mirna, Dellon, Evan S., Furuta, Glenn T., Gonsalves, Nirmala, Hirano, Ikuo, Moawad, Fouad J., Biedermann, Luc, Safroneeva, Ekaterina, Schoepfer, Alain M., and Simon, Hans-Uwe

Published
2024
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2. A Multicenter Long-Term Cohort Study of Eosinophilic Esophagitis Variants and Their Progression to Eosinophilic Esophagitis Over Time

Author

Greuter, Thomas, Straumann, Alex, Fernandez-Marrero, Yuniel, Germic, Nina, Hosseini, Aref, Chanwangpong, Apinya, Yousefi, Shida, Simon, Dagmar, Collins, Margaret H., Bussmann, Christian, Chehade, Mirna, Dellon, Evan S., Furuta, Glenn T., Gonsalves, Nirmala, Hirano, Ikuo, Moawad, Fouad J., Biedermann, Luc, Safroneeva, Ekaterina, Schoepfer, Alain M., and Simon, Hans-Uwe

Published
2024
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3. The Cellular Functions of Eosinophils: Collegium Internationale Allergologicum (CIA) Update 2020

Author

Simon, Hans-Uwe, Yousefi, Shida, Germic, Nina, Arnold, Isabelle C, Haczku, Angela, Karaulov, Alexander V, Simon, Dagmar, and Rosenberg, Helene F

Subjects
Good Health and Well Being, Animals, Antibody Formation, Eosinophils, Humans, Hypereosinophilic Syndrome, Immunity, Cellular, Immunomodulation, Inflammation, Interleukin-5, Wound Healing, Asthma, Eosinophil cytolysis, Eosinophil degranulation, Eosinophil extracellular traps, Hypereosinophilic syndromes, Major basic protein, M2 macrophages, Mast cells, Targeted therapy, Immunology, Allergy
Abstract

Eosinophils and their secretory mediators play an important role in the pathogenesis of infectious and inflammatory disorders. Although eosinophils are largely evolutionally conserved, their physiologic functions are not well understood. Given the availability of new eosinophil-targeted depletion therapies, there has been a renewed interest in understanding eosinophil biology as these strategies may result in secondary disorders when applied over long periods of time. Recent data suggest that eosinophils are not only involved in immunological effector functions but also carry out tissue protective and immunoregulatory functions that actively contribute to the maintenance of homeostasis. Prolonged eosinophil depletion may therefore result in the development of secondary disorders. Here, we review recent literature pointing to important roles for eosinophils in promoting immune defense, antibody production, activation of adipose tissue, and tissue remodeling and fibrosis. We also reflect on patient data from clinical trials that feature anti-eosinophil therapeutics.

Published
2020

4. Oxidative damage of SP-D abolishes control of eosinophil extracellular DNA trap formation.

Author

Yousefi, Shida, Sharma, Satish K, Stojkov, Darko, Germic, Nina, Aeschlimann, Salome, Ge, Moyar Q, Flayer, Cameron H, Larson, Erik D, Redai, Imre G, Zhang, Suhong, Koziol-White, Cynthia J, Karikó, Katalin, Simon, Hans-Uwe, and Haczku, Angela

Subjects
Eosinophils, Cells, Cultured, Animals, Humans, Mice, Asthma, Hypersensitivity, Ozone, Pulmonary Surfactant-Associated Protein D, Oxidants, Photochemical, Oxidative Stress, Extracellular Traps, eosinophil extracellular traps, eosinophils, surfactant pulmonary-associated protein D, Cells, Cultured, Oxidants, Photochemical, Immunology, Biochemistry and Cell Biology
Abstract

The asthmatic airways are highly susceptible to inflammatory injury by air pollutants such as ozone (O3 ), characterized by enhanced activation of eosinophilic granulocytes and a failure of immune protective mechanisms. Eosinophil activation during asthma exacerbation contributes to the proinflammatory oxidative stress by high levels of nitric oxide (NO) production and extracellular DNA release. Surfactant protein-D (SP-D), an epithelial cell product of the airways, is a critical immune regulatory molecule with a multimeric structure susceptible to oxidative modifications. Using recombinant proteins and confocal imaging, we demonstrate here that SP-D directly bound to the membrane and inhibited extracellular DNA trap formation by human and murine eosinophils in a concentration and carbohydrate-dependent manner. Combined allergic airway sensitization and O3 exposure heightened eosinophilia and nos2 mRNA (iNOS) activation in the lung tissue and S-nitrosylation related de-oligomerisation of SP-D in the airways. In vitro reproduction of the iNOS action led to similar effects on SP-D. Importantly, S-nitrosylation abolished the ability of SP-D to block extracellular DNA trap formation. Thus, the homeostatic negative regulatory feedback between SP-D and eosinophils is destroyed by the NO-rich oxidative lung tissue environment in asthma exacerbations.

Published
2018

11. Sa1182: LONGITUDINAL FOLLOW-UP OF PATIENTS WITH EOSINOPHILIC ESOPHAGITIS VARIANTS AND THEIR POTENTIAL TO PROGRESS TO EOE: A CLINICAL, HISTOLOGICAL AND MOLECULAR MULTI-CENTER ANALYSIS

Author

Greuter, Thomas, primary, Straumann, Alex, additional, Fernandez-Marrero, Yuniel, additional, Germic, Nina, additional, Hosseini, Aref, additional, Yousefi, Shida, additional, Simon, Dagmar, additional, Collins, Margaret H., additional, Bussmann, Christian, additional, Chehade, Mirna, additional, Dellon, Evan S., additional, Furuta, Glenn, additional, Gonsalves, Nirmala, additional, Hirano, Ikuo, additional, Moawad, Fouad J., additional, Biedermann, Luc, additional, Safroneeva, Ekaterina, additional, Schoepfer, Alain M., additional, and Simon, Hans-Uwe, additional

Published
2022
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12. Characterization of eosinophilic esophagitis variants by clinical, histological, and molecular analyses: A cross‐sectional multi‐center study

Author

Greuter, Thomas, primary, Straumann, Alex, additional, Fernandez‐Marrero, Yuniel, additional, Germic, Nina, additional, Hosseini, Aref, additional, Yousefi, Shida, additional, Simon, Dagmar, additional, Collins, Margaret H., additional, Bussmann, Christian, additional, Chehade, Mirna, additional, Dellon, Evan S., additional, Furuta, Glenn T., additional, Gonsalves, Nirmala, additional, Hirano, Ikuo, additional, Moawad, Fouad J., additional, Biedermann, Luc, additional, Safroneeva, Ekaterina, additional, Schoepfer, Alain M., additional, and Simon, Hans‐Uwe, additional

Published
2022
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13. ATG5 promotes eosinopoiesis, but inhibits eosinophil effector functions

Author

Germic, Nina, primary, Hosseini, Aref, additional, Stojkov, Darko, additional, Oberson, Kevin, additional, Claus, Meike, additional, Benarafa, Charaf, additional, Calzavarini, Sara, additional, Angelillo-Scherrer, Anne, additional, Arnold, Isabelle C., additional, Müller, Anne, additional, Riether, Carsten, additional, Yousefi, Shida, additional, and Simon, Hans-Uwe, additional

Published
2021
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17. Untangling “NETosis” from NETs

Author

Yousefi, Shida, primary, Stojkov, Darko, additional, Germic, Nina, additional, Simon, Dagmar, additional, Wang, Xiaoliang, additional, Benarafa, Charaf, additional, and Simon, Hans‐Uwe, additional

Published
2019
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18. Oxidative damage of SP-D abolishes control of eosinophil extracellular DNA trap formation

Author

Yousefi, Shida, Sharma, Satish K, Stojkov, Darko, Germic, Nina, Aeschlimann, Salome, Ge, Moyar Q, Flayer, Cameron H, Larson, Erik D, Redai, Imre G, Zhang, Suhong, Koziol-White, Cynthia J, Karikó, Katalin, Simon, Hans-Uwe, and Haczku, Angela

Subjects
respiratory system, 610 Medicine & health, respiratory tract diseases, 3. Good health
Abstract

The asthmatic airways are highly susceptible to inflammatory injury by air pollutants such as ozone (O ), characterized by enhanced activation of eosinophilic granulocytes and a failure of immune protective mechanisms. Eosinophil activation during asthma exacerbation contributes to the proinflammatory oxidative stress by high levels of nitric oxide (NO) production and extracellular DNA release. Surfactant protein-D (SP-D), an epithelial cell product of the airways, is a critical immune regulatory molecule with a multimeric structure susceptible to oxidative modifications. Using recombinant proteins and confocal imaging, we demonstrate here that SP-D directly bound to the membrane and inhibited extracellular DNA trap formation by human and murine eosinophils in a concentration and carbohydrate-dependent manner. Combined allergic airway sensitization and O exposure heightened eosinophilia and nos2 mRNA (iNOS) activation in the lung tissue and S-nitrosylation related de-oligomerisation of SP-D in the airways. In vitro reproduction of the iNOS action led to similar effects on SP-D. Importantly, S-nitrosylation abolished the ability of SP-D to block extracellular DNA trap formation. Thus, the homeostatic negative regulatory feedback between SP-D and eosinophils is destroyed by the NO-rich oxidative lung tissue environment in asthma exacerbations.

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