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2,704 results on '"Germanà, A."'

1. Upper endoscopy in elderly patients: a multicentre, cross-sectional study

Author

Zullo, Angelo, De Francesco, Vincenzo, Amato, Arnaldo, Bergna, Irene, Bendia, Emanuele, Giorgini, Giorgia, Buscarini, Elisabetta, Manfredi, Guido, Cadoni, Sergio, Cannizzaro, Renato, Realdon, Stefano, Ciuffi, Mario, Ignomirelli, Orazio, Da Massa Carrara, Paola, Finucci, Giovanni, Di Somma, Antonietta, Frandina, Chiara, Loria, Mariafrancesca, Galeazzi, Francesca, Ferrara, Francesco, Gemme, Carlo, Bertetti, Noemi Sara, Gentili, Federica, Lotito, Antonio, Germanà, Bastianello, Russo, Nunzia, Grande, Giuseppe, Conigliaro, Rita, Cravero, Federico, Venezia, Giovanna, Marmo, Riccardo, Senneca, Piera, Milano, Angelo, Efthymakis, Konstantinos, Monica, Fabio, Montalto, Paolo, Lombardi, Mario, Morelli, Olivia, Castellani, Danilo, Nigro, Daniela, Festa, Roberto, Peralta, Sergio, Grasso, Maria, Privitera, Antonello, Di Stefano, Maria Emanuela, Scaccianoce, Giuseppe, Loiacono, Mariangela, Segato, Sergio, Balzarini, Marco, Satta, Paolo Usai, Lai, Mariantonia, Fortunato, Francesca, and Manta, Raffaele

Published
2024
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3. Uniform multi-penalty regularization for linear ill-posed inverse problems

Author

Bortolotti, Villiam, Landi, Germana, and Zama, Fabiana

Subjects
Mathematics - Numerical Analysis
Abstract

This study examines, in the framework of variational regularization methods, a multi-penalty regularization approach which builds upon the Uniform PENalty (UPEN) method, previously proposed by the authors for Nuclear Magnetic Resonance (NMR) data processing. The paper introduces two iterative methods, UpenMM and GUpenMM, formulated within the Majorization-Minimization (MM) framework. These methods are designed to identify appropriate regularization parameters and solutions for linear inverse problems utilizing multi-penalty regularization. The paper demonstrates the convergence of these methods and illustrates their potential through numerical examples in one and two-dimensional scenarios, showing the practical utility of point-wise regularization terms in solving various inverse problems.

Published
2023

5. Microclimatic Monitoring for Archeological Shelters Across Indoor Comfort and Conservation: The Case Study of the Villa del Casale in Piazza Armerina (Sicily, Italy)

Author

Nicolini, Elvira, Germanà, Maria Luisa, Alberghina, Maria Francesca, Schiavone, Salvatore, Prestileo, Fernanda, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, Gawad, Iman O., Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Germanà, Maria Luisa, editor, Akagawa, Natsuko, editor, Versaci, Antonella, editor, and Cavalagli, Nicola, editor

Published
2024
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6. Quality in the Conservation of Architectural Heritage: Methodological Issues for Developing Sustainable Practices

Author

Germanà, Maria Luisa, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, Gawad, Iman O., Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Germanà, Maria Luisa, editor, Akagawa, Natsuko, editor, Versaci, Antonella, editor, and Cavalagli, Nicola, editor

Published
2024
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7. 3D Modeling and Augmented Reality in Education: An Effective Application for the Museo dei Saperi e delle Mirabilia of the University of Catania

Author

Barone, Germana, Garozzo, Raissa, Russo, Gloria, Santagati, Cettina, Sinitò, Diego, Spironello, Marilisa Yolanda, Stanco, Filippo, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Foresti, Gian Luca, editor, Fusiello, Andrea, editor, and Hancock, Edwin, editor

Published
2024
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10. An automatic L1-based regularization method for the analysis of FFC dispersion profiles with quadrupolar peaks

Author

Landi, Germana, Spinelli, Giovanni V., Zama, Fabiana, Martino, Delia Chillura, Conte, Pellegrino, Meo, Paolo Lo, and Bortolotti, Villiam

Subjects
Mathematics - Numerical Analysis, 65F22, 65K10, G.1.0, G.1.6, G.4
Abstract

Fast Field-Cycling Nuclear Magnetic Resonance relaxometry is a non-destructive technique to investigate molecular dynamics and structure of systems having a wide range of applications such as environment, biology, and food. Besides a considerable amount of literature about modeling and application of such technique in specific areas, an algorithmic approach to the related parameter identification problem is still lacking. We believe that a robust algorithmic approach will allow a unified treatment of different samples in several application areas. In this paper, we model the parameters identification problem as a constrained $L_1$-regularized non-linear least squares problem. Following the approach proposed in [Analytical Chemistry 2021 93 (24)], the non-linear least squares term imposes data consistency by decomposing the acquired relaxation profiles into relaxation contributions associated with 1H-1H and 1H-14N dipole-dipole interactions. The data fitting and the L1-based regularization terms are balanced by the so-called regularization parameter. For the parameters identification, we propose an algorithm that computes, at each iteration, both the regularization parameter and the model parameters. In particular, the regularization parameter value is updated according to a Balancing Principle and the model parameters values are obtained by solving the corresponding $L_1$-regularized non-linear least squares problem by means of the non-linear Gauss-Seidel method. We analyse the convergence properties of the proposed algorithm and run extensive testing on synthetic and real data. A Matlab software, implementing the presented algorithm, is available upon request to the authors.

Published
2022

11. Prevalence of Endoscopic and Histological Lesions at Upper Endoscopy: A Cross-Sectional, Multicentre Study in Clinical Practice

Author

Vincenzo De Francesco, Angelo Zullo, Arnaldo Amato, Irene Bergna, Emanuele Bendia, Giorgia Giorgini, Elisabetta Buscarini, Guido Manfredi, Sergio Cadoni, Renato Cannizzaro, Stefano Realdon, Mario Ciuffi, Orazio Ignomirelli, Paola Da Massa Carrara, Giovanni Finucci, Antonietta Di Somma, Chiara Frandina, Mariafrancesca Loria, Francesca Galeazzi, Francesco Ferrara, Carlo Gemme, Noemi Sara Bertetti, Federica Gentili, Antonio Lotito, Bastianello Germanà, Nunzia Russo, Giuseppe Grande, Rita Conigliaro, Federico Cravero, Giovanna Venezia, Riccardo Marmo, Piera Senneca, Angelo Milano, Konstantinos Efthymakis, Fabio Monica, Paolo Montalto, Mario Lombardi, Olivia Morelli, Danilo Castellani, Daniela Nigro, Roberto Festa, Sergio Peralta, Maria Grasso, Antonino Carlo Privitera, Maria Emanuela Di Stefano, Giuseppe Scaccianoce, Mariangela Loiacono, Sergio Segato, Marco Balzarini, Paolo Usai Satta, Mariantonia Lai, and Raffaele Manta

Subjects
upper endoscopy, peptic ulcer, cancer, helicobacter pylori, precancerous lesions, esofagogastroduodenoscopia, ulcera peptica, câncer, h. pylori, lesões pré-cancerosas, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background/Aim: Prevalence of gastroduodenal endoscopic and histological lesions may modify over time due to different factors. We assessed both macroscopic and histological lesions currently detected at upper endoscopy performed in routine practice. Patients and Methods: Clinical, endoscopic, and histological data of consecutive adult patients referred for upper endoscopy in the 28 participating centres were analysed. Only patients who underwent the first endoscopic examination were considered. Prevalence of erosive/ulcerative lesions, cancers and extensive precancerous lesions in the stomach, and Helicobacter pylori infection was computed. Results: A total of 1,431 patients underwent endoscopy for gastro-oesophageal reflux symptoms (31.5%), dyspepsia (29.4%), or alarm symptoms (18.5%). Erosive oesophagitis or Barrett’s oesophagus was detected in 210 (14.7%) cases, peptic ulcer in 49 (3.4%), and a neoplastic lesion in 17 (1.2%). H. pylori was present in 201 (22.6%) cases, and extensive precancerous lesions on gastric mucosa in 46 (5.6%) patients. Gastric lesions were more prevalent in patients aged ≥50 years (26% vs. 18%; p = 0.001), and peptic ulcers were more frequently detected in patients with H. pylori (9.4% vs. 2.3%; p = 0.001) and in males (5.8% vs. 1.6%; p = 0.001), while neoplastic lesions in patients with alarm symptoms (3.8% vs. 0.6%; p = 0.001). Conclusions: The overall endoscopic lesions were more prevalent in patients aged ≥50 years, peptic ulcer and erosions were more frequent in H. pylori-infected patients, and extensive gastric precancerous lesions were present in less than 6% of cases.

Published
2024
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12. Corrigendum: Adherence to European society of gastrointestinal endoscopy quality performance measures for upper and lower gastrointestinal endoscopy: a nationwide survey from the Italian society of digestive endoscopy

Author

Rocco Maurizio Zagari, Leonardo Frazzoni, Lorenzo Fuccio, Helga Bertani, Stefano Francesco Crinò, Andrea Magarotto, Elton Dajti, Andrea Tringali, Paola Da Massa Carrara, Gianpaolo Cengia, Enrico Ciliberto, Rita Conigliaro, Bastianello Germanà, Antonietta Lamazza, Antonio Pisani, Giancarlo Spinzi, Maurizio Capelli, Franco Bazzoli, and Luigi Pasquale

Subjects
endoscopy, quality, performance measure, ESGE, guidelines, Medicine (General), R5-920
Published
2024
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14. MUPen2DTool: a Matlab Tool for 2D Nuclear Magnetic Resonance relaxation data inversion

Author

Bortolotti, Villiam, Brizi, Leonardo, Landi, Germana, Nagmutdinova, Anastasiia, and Zama, Fabiana

Subjects
Computer Science - Mathematical Software, 65Z05, 68V35, D.0, G.1, I.6
Abstract

Accurate and efficient analysis of materials properties from Nuclear Magnetic Resonance (NMR) relaxation data requires robust and efficient inversion procedures. Despite the great variety of applications requiring to process two-dimensional NMR data (2DNMR), a few software tools are freely available. The aim of this paper is to present MUPen2DTool, an open-source MATLAB based software tool for 2DNMR data inversion. The user can choose among several types of NMR experiments, and the software provides codes that can be used and extended easily. Furthermore, a MATLAB interface makes it easier to include users own data. The practical use is demonstrated in the reported examples of both synthetic and real NMR data.

Published
2022

15. Atezolizumab and chemotherapy for advanced or recurrent endometrial cancer (AtTEnd): a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Zola, Paolo, Casanova, Claudia, Arcangeli, Valentina, Antonuzzo, Lorenzo, Gadducci, Angiolo, Cosio, Stefania, Clamp, Andrew, Persic, Mojca, McNeish, Ian, Tookman, Laura, Redondo Sanchez, Andrés, Choi, Chel Hun, Baldini, Editta, Palaia, Innocenza, Benedetti Panici, Pierluigi, Takahashi, Nobutaka, Lombard, Janine, Ardizzoia, Antonio, Bologna, Alessandra, Herrero Ibáñez, Ana Maria, Musolino, Antonino, Márquez Vázquez, Raúl, Pietzner, Klaus, Braicu, Elena, Heinzelmann-Schwarz, Viola A., Powell, Melanie, Yokoyama, Yoshihito, Baron-Hay, Sally, Abeni, Chiara, Martin Lorente, Cristina, Cueva, Juan Fernando, Trillsch, Fabian, Heitz, Florian, Ataseven, Beyhan, Petru, Edgar, Heubner, MartinLeonhard, Sadozye, Azmat Hassanq, Dubey, Sidharth, Tazbirkova, Andrea, Tiley, Susan, Chrystal, Kathryn, Kim, Sang Wun, Fehr, Mathias, Scatchard, Kate, Anand, Anjana, Taylor, Alexandra, Watary, Hidemichi, Enomoto, Takayuki, Yoshihara, Kosuke, Selva-Nayagam, Sudarsha, Karki, Bhaskar, Harrison, Michelle, Wilkinson, Kate, Goh, Jeffrey, Glasgow, Amanda, Chantrill, Lorraine, Lee, Chulmin, Bertolini, Alessandro, Narducci, Filomena, Bellotti, Giovanna, Fusco, Vittorio, Aebi, Stefan, Del Grande, Maria, Colombo, Ilaria, Tokunaga, Hideki, Shigeta, Shogo, Goss, Geraldine, Siow, Zhen Rong, Steer, Christopher, Lin, Hao, Lee, Kwang-Beom, Di Meglio, Giovanni, Massa, Elena, De Marino, Elvira, Tortora, Vincenzo, Palacio Vazquez, Isabel, Tsuji, Kosuke, Tominaga, Eiichiro, Black, Allison, So, Kyeong A, Suh, Dong Hoon, Lee, Keun Ho, Kim, Yong Man, Fossati, Roldano, Carlucci, Luciano, Barberis, Massimo, Torri, Valter, Santoni, Anna, Colombo, Nicoletta, Biagioli, Elena, Harano, Kenichi, Galli, Francesca, Hudson, Emma, Antill, Yoland, Rabaglio, Manuela, Marmé, Frederic, Marth, Christian, Parma, Gabriella, Fariñas-Madrid, Lorena, Nishio, Shin, Allan, Karen, Lee, Yeh Chen, Piovano, Elisa, Pardo, Beatriz, Nakagawa, Satoshi, McQueen, John, Zamagni, Claudio, Manso, Luis, Takehara, Kazuhiro, Tasca, Giulia, Ferrero, Annamaria, Tognon, Germana, Lissoni, Andrea Alberto, Petrella, Mariacristina, Laudani, Maria Elena, Rulli, Eliana, Uggeri, Sara, and Barretina Ginesta, M Pilar

Published
2024
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18. Long-term Environmental Enrichment Normalizes Schizophrenia-like Abnormalities and Promotes Hippocampal Slc6a4 Promoter Demethylation in Mice Submitted to a Two-hit Model

Author

Arraes, Greicy Coelho, Barreto, Francisco Stefânio, Vasconcelos, Germana Silva, Lima, Camila Nayane de Carvalho, da Silva, Francisco Eliclécio Rodrigues, Ribeiro, Wesley Lyeverton Correia, de Sousa, Francisca Cléa Florenço, Furtado, Cristiana Libardi Miranda, and Macêdo, Danielle S.

Published
2024
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20. Low Colorectal Cancer Risk After Resection of High-Risk Pedunculated Polyps

Author

Zorzi, Manuel, Battagello, Jessica, Amidei, Claudio Barbiellini, Antonelli, Giulio, Germanà, Bastianello, Valiante, Flavio, Benvenuti, Stefano, Tringali, Alberto, Bortoluzzi, Francesco, Cervellin, Erica, Giacomin, Davide, Meggiato, Tamara, Rizzotto, Erik Rosa, Fregonese, Diego, Dinca, Manuela, Baldassarre, Gianluca, Scalon, Paola, Pantalena, Maurizio, Milan, Luisa, Bulighin, Gianmarco, Di Piramo, Daniele, Azzurro, Maurizio, Gabbrielli, Armando, Repici, Alessandro, Rugge, Massimo, and Hassan, Cesare

Published
2024
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21. Alle origini del simbolismo medievale

Author

Giancarlo Germanà Bozza

Subjects
medioevo, simbolismo, iconografia, History of the arts, NX440-632, Archaeology, CC1-960
Abstract

In the Middle Ages, the dimension of the imaginary often confu-sed the perception of reality with a process of abstraction. In this way, the representation of a cathedral could at the same time be the very idea of the cathedral. The imaginary was part of the field of representation not as sim-ple reproduction but as the transposition of an internal dimension. In art, as in literature, real representations are often used to evoke imaginary con-cepts. The dimension of the imaginary was accompanied by that of the symbolic, which consisted in the reference of the object considered to an implied, historical and ideal system of values.

Published
2023
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22. Potential Role of mRNA in Estimating Postmortem Interval: A Systematic Review

Author

Vincenzo Cianci, Cristina Mondello, Daniela Sapienza, Maria Cristina Guerrera, Alessio Cianci, Annalisa Cracò, Fausto Omero, Vittorio Gioffrè, Patrizia Gualniera, Alessio Asmundo, and Antonino Germanà

Subjects
PMI estimation, postmortem interval estimation, RNA degradation, mRNA degradation, forensic pathology, forensic sciences, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Although the postmortem interval estimation still represents one of the main goals of forensic medicine, there are still several limitations that weigh on the methods most used for its determination: for this reason, even today, precisely estimating the postmortem interval remains one of the most important challenges in the forensic pathology field. To try to overcome these limitations, in recent years, numerous studies have been conducted on the potential use of the mRNA degradation time for reaching a more precise post mortem interval (PMI) estimation. An evidence-based systematic review of the literature has been conducted to evaluate the state of the art of the knowledge focusing on the potential correlation between mRNA degradation and PMI estimation. The research has been performed using the electronic databases PubMed and Scopus. The analysis conducted made it possible to confirm the potential applicability of mRNA for reaching a more precise PMI estimation. The analysis of the results highlighted the usefulness of some mRNAs, such as β-actin and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA, especially in short time frames, within a few hours or days of death. The matrices on which these analyses were conducted were also analyzed, resulting in less exposure to the external environment, including the heart, brain, and dental pulp. The major limitations were also reported, including the short time intervals analyzed in most of the articles, the lack of mathematical models, and the failure to report the error rate between the mRNA degradation time and PMI. Given the still small number of published articles, the lack of globally recognized standardized methods, and the numerous techniques used to evaluate the mRNA degradation times, numerous and larger studies are still necessary to reach more solid and shared evidence.

Published
2024
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23. From Proliferation to Protection: Immunohistochemical Profiling of Cardiomyocytes and Immune Cells in Molly Fish Hearts

Author

Giacomo Zaccone, Doaa M. Mokhtar, Alessio Alesci, Gioele Capillo, Marco Albano, Manal T. Hussein, Marialuisa Aragona, Antonino Germanà, Eugenia R. Lauriano, and Ramy K. A. Sayed

Subjects
atrium, regeneration, rodlet cells, SOX9, TCs, Biology (General), QH301-705.5, Genetics, QH426-470
Abstract

Unlike adult mammalian cardiomyocytes, cardiomyocytes in teleosts display high proliferative capacity throughout adulthood. This study aimed to identify the immunohistochemical profiles of cardiomyocytes and immune cells in the hearts of Molly fish by assessing the immunolabelling expression of key proteins involved in cell proliferation, differentiation, and tissue protection. The cardiac anatomy of Molly fish includes the atrium, ventricle, and bulbus arteriosus. The expression of SOX9, NF-κB, myostatin, and S100 proteins in myocardial cells indicates the proliferative features of the heart in Molly fish. The bulbus arteriosus is characterized by collagenous chambers and smooth muscle cells that express Ach and iba1. The atrium of Molly fish serves as a storage unit for rodlet cells and immune cells. Rodlet cells displayed immunoreactivity to NF-κB, iba1, Olig2, Ach, and S100 proteins, suggesting their roles in the immune response within the heart. Furthermore, telocytes (TCs) have emerged as a significant component of the atrium of Molly fish, expressing Ach, CD68, S100 protein, and iba1. These expressions indicate the involvement of TCs in multiple signaling pathways that contribute to heart architecture. This study delineates the intricate relationship between cardiomyocytes and innate immune cells in Molly fish.

Published
2024
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24. Piezo 1 and Piezo 2 in the Chemosensory Organs of Zebrafish (Danio rerio)

Author

Marialuisa Aragona, Kamel Mhalhel, Marzio Cometa, Gianluca Antonio Franco, Giuseppe Montalbano, Maria Cristina Guerrera, Maria Levanti, Rosaria Laurà, Francesco Abbate, José A. Vega, and Antonino Germanà

Subjects
Piezo 1, Piezo 2, zebrafish, sensory organ, taste buds, isolated chemosensory cells, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

The ion channels Piezo 1 and Piezo 2 have been identified as membrane mechano-proteins. Studying mechanosensitive channels in chemosensory organs could help in understanding the mechanisms by which these channels operate, offering new therapeutic targets for various disorders. This study investigates the expression patterns of Piezo proteins in zebrafish chemosensory organs. For the first time, Piezo protein expression in adult zebrafish chemosensory organs is reported. In the olfactory epithelium, Piezo 1 immunolabels kappe neurons, microvillous cells, and crypt neurons, while Calretinin is expressed in ciliated sensory cells. The lack of overlap between Piezo 1 and Calretinin confirms Piezo 1’s specificity for kappe neurons, microvillous cells, and crypt neurons. Piezo 2 shows intense immunoreactivity in kappe neurons, one-ciliated sensory cells, and multi-ciliated sensory cells, with overlapping Calretinin expression, indicating its olfactory neuron nature. In taste buds, Piezo 1 immunolabels Merkel-like cells at the bases of cutaneous and pharyngeal taste buds and the light and dark cells of cutaneous and oral taste buds. It also marks the dark cells of pharyngeal taste buds and support cells in oral taste buds. Piezo 2 is found in the light and dark cells of cutaneous and oral taste buds and isolated chemosensory cells. These findings provide new insights into the distribution of Piezo channels in zebrafish chemosensory organs, enhancing our understanding of their sensory processing and potential therapeutic applications.

Published
2024
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29. The interaction of patients’ physical status and time to endoscopy on mortality risk in patients with upper gastrointestinal bleeding: A national prospective cohort study

Author

Amitrano, L, Anderloni, A, Andriulli, A, Annese, V, Baldassarre, G, Bargiggia, S, Balzano, A, Bazzoli, F, Bennato, R, Bianco, M A, Bizzotto, A, Boarino, V, Bonanomi, AG, Borgheresi, P, Bresci, G, Buffoli, F, Buscarini, E, Castrignanò, G, Cavallaro, LG, Cesaro, P, Chirico, A, Cipolletta, F, Cipolletta, L, Conigliaro, R, Conte, D, Costamagna, G, Covello, F, D'Amico, G, De Fanis, C, De Filippo, FR, de Franchis, R, Dell‘Era, A, De Nigris, F, De Matthaeis, M, Di Giorgio, P, Di Giulio, E, Esposito, P, Ferraris, L, Filippino, A, Franceschi, M, Furio, L, Germana’, B, Grassia, R, Imperiali, G, Lamanda, R, Lauri, A, Londoni, C, Mangiafico, S, Manno, M, Marmo, C, Merighi, A, Meroni, R, Metrangolo, S, Montalbano, L M, Napolitano, G, Nucci, A, Orsini, L, Parente, F, Parravicini, M, Paterlini, A, Pumpo, R, Purita, L, Repici, A, Riccioni, ME, Russo, A, Segato, S, Sorrentino, I, Spinzi, G, Spotti, D, Tortora, A, Tomba, C, Triossi, O, Zagari, RM, Zambelli, A, Bucci, Cristina, Marmo, Clelia, Soncini, Marco, Riccioni, Maria Elena, Laursen, Stig B., Gralnek, Ian M., and Marmo, Riccardo

Published
2024
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30. A mixed-frequency approach for exchange rates predictions

Author

Mattera, Raffaele, Misuraca, Michelangelo, Scepi, Germana, and Spano, Maria

Subjects
Statistics - Applications, 62J05
Abstract

Selecting an appropriate statistical model to forecast exchange rates is still today a relevant issue for policymakers and central bankers. The so-called Meese and Rogoff puzzle assesses that exchange rate fluctuations are unpredictable. In the literature, a lot of studies tried to solve the puzzle finding alternative predictors and statistical models based on temporal aggregation. In this paper, we propose an approach based on mixed frequency models to overcome the lack of information caused by temporal aggregation. We show the effectiveness of our approach in comparison with other proposed methods by performing CAD/USD exchange rate predictions.

Published
2021
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31. Directional TGV-based image restoration under Poisson noise

Author

di Serafino, Daniela, Landi, Germana, and Viola, Marco

Subjects
Mathematics - Numerical Analysis, Mathematics - Optimization and Control, 90C25, 65K05, 94A08
Abstract

We are interested in the restoration of noisy and blurry images where the texture mainly follows a single direction (i.e., directional images). Problems of this type arise, for example, in microscopy or computed tomography for carbon or glass fibres. In order to deal with these problems, the Directional Total Generalized Variation (DTGV) was developed by Kongskov et al. in 2017 and 2019, in the case of impulse and Gaussian noise. In this article we focus on images corrupted by Poisson noise, extending the DTGV regularization to image restoration models where the data fitting term is the generalized Kullback-Leibler divergence. We also propose a technique for the identification of the main texture direction, which improves upon the techniques used in the aforementioned work about DTGV. We solve the problem by an ADMM algorithm with proven convergence and subproblems that can be solved exactly at a low computational cost. Numerical results on both phantom and real images demonstrate the effectiveness of our approach., Comment: 20 pages, 1 table, 13 figures

Published
2021

32. TGV-based restoration of Poissonian images with automatic estimation of the regularization parameter

Author

di Serafino, Daniela, Landi, Germana, and Viola, Marco

Subjects
Mathematics - Numerical Analysis, Mathematics - Optimization and Control, 90C25, 65K05, 94A08
Abstract

The problem of restoring images corrupted by Poisson noise is common in many application fields and, because of its intrinsic ill posedness, it requires regularization techniques for its solution. The effectiveness of such techniques depends on the value of the regularization parameter balancing data fidelity and regularity of the solution. Here we consider the Total Generalized Variation regularization introduced in [SIAM J. Imag. Sci, 3(3), 492-526, 2010], which has demonstrated its ability of preserving sharp features as well as smooth transition variations, and introduce an automatic strategy for defining the value of the regularization parameter. We solve the corresponding optimization problem by using a 3-block version of ADMM. Preliminary numerical experiments support the proposed approach., Comment: 7 pages, 1 table, 3 figures

Published
2021

33. A Simulator for Minero-Petrographic and Chemical Research Instruments

Author

Sinitò, Diego, Verderame, Alessandro, Lombardo, Carmelo, Treffiletti, Alessandro, Fugazzotto, Maura, Allegra, Dario, Santarcangelo, Vito, Stanco, Filippo, Barone, Germana, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Rousseau, Jean-Jacques, editor, and Kapralos, Bill, editor

Published
2023
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35. Operational Improvement in Pediatric Neurosurgery

Author

Spacca, Barbara, Luglietto, Davide, Vatavu, Octavian, D’Incerti, Ludovico, Tuccinardi, Germana, Butti, Desy, Bussolin, Leonardo, Mussa, Federico, Genitori, Lorenzo, Lima, Mario, editor, and Mondardini, Maria Cristina, editor

Published
2023
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39. Immunogenicity and reactogenicity of modified vaccinia Ankara pre-exposure vaccination against mpox according to previous smallpox vaccine exposure and HIV infection: prospective cohort study

Author

Anzalone, Enza, Camici, Marta, Cannone, Fabio, Caputi, Priscilla, Cimaglia, Claudia, Corso, Rita, Cristofanelli, Flavia, Cruciani, Stefania, De Marco, Nicola, De Ponte, Chiara, Del Duca, Giulia, Faccendini, Paolo, Faraglia, Francesca, Faticoni, Augusto, Fusto, Marisa, Gebremeskel, Saba, Giancola, Maria Letizia, Giannico, Giuseppina, Gili, Simona, Iannella, Maria Rosaria, Junea, Angela, Lamonaca, Alessandra, Marani, Alessandra, Masone, Erminia, Mastrorosa, Ilaria, Mazzotta, Stefania, Nappo, Alessandra, Natalini, Giorgia, Parisi, Alfredo, Passacantilli, Sara, Paulicelli, Jessica, Plazzi, Maria Maddalena, Possi, Adriano, Preziosi, Gianni, Rosati, Silvia, Rubino, Marika, Scanzano, Pietro, Scorzolini, Laura, Tomassi, Virginia, Vescovo, Maurizio, Vita, Serena, Caterini, Luciano, Coppola, Luigi, Kontogiannis, Dimitra, D'Ettorre, Gabriella, Ridolfi, Marco, Di Giambenedetto, Simona, Farinacci, Damiano, Latini, Alessandra, Marchili, Mauro, Marocco, Raffaella, Mazzotta, Valentina, Lepri, Alessandro Cozzi, Matusali, Giulia, Cimini, Eleonora, Piselli, Pierluca, Aguglia, Camilla, Lanini, Simone, Colavita, Francesca, Notari, Stefania, Oliva, Alessandra, Meschi, Silvia, Casetti, Rita, Mondillo, Vanessa, Vergori, Alessandra, Bettini, Aurora, Grassi, Germana, Pinnetti, Carmela, Lapa, Daniele, Tartaglia, Eleonora, Gallì, Paola, Mondi, Annalisa, Montagnari, Giulia, Gagliardini, Roberta, Nicastri, Emanuele, Lichtner, Miriam, Sarmati, Loredana, Tamburrini, Enrica, Mastroianni, Claudio, Stingone, Christof, Siddu, Andrea, Barca, Alessandra, Fontana, Carla, Agrati, Chiara, Girardi, Enrico, Vaia, Francesco, Maggi, Fabrizio, and Antinori, Andrea

Published
2024
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43. Primaquine dose and the risk of haemolysis in patients with uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis

Author

Adhikari, Bipin, Alam, Mohammad Shafiul, Anstey, Nicholas M, Assefa, Ashenafi, Boyd, Sarah C, Chau, Nguyen Hoang, Day, Nicholas PJ, Degaga, Tamiru Shibiru, Dondorp, Arjen M, Ferreira, Marcelo Urbano, Ghimire, Prakash, Green, Justin A, Khan, Wasif Ali, Koh, Gavin CKW, Mekuria, Asrat Hailu, Naadim, Mohammad Nader, Nelwan, Erni J, Nosten, Francois, Pasaribu, Ayodhia Pitaloka, Price, David J, Stepniewska, Kasia, von Seidlein, Lorenz, William, Timothy, Woodrow, Charles J, Woyessa, Adugna, Rajasekhar, Megha, Simpson, Julie A, Ley, Benedikt, Edler, Peta, Chu, Cindy S, Abreha, Tesfay, Awab, Ghulam R, Baird, J Kevin, Bancone, Germana, Barber, Bridget E, Grigg, Matthew J, Hwang, Jimee, Karunajeewa, Harin, Lacerda, Marcus V G, Ladeia-Andrade, Simone, Llanos-Cuentas, Alejandro, Pukrittayakamee, Sasithon, Rijal, Komal R, Saravu, Kavitha, Sutanto, Inge, Taylor, Walter R J, Thriemer, Kamala, Watson, James A, Guerin, Philippe J, White, Nicholas J, Price, Ric N, and Commons, Robert J

Published
2024
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45. ProteoCure: A European network to fine-tune the proteome

Author

Abbas, Mohamad, Barrio, Rosa, Blattner, Christine, Brix, Klaudia, Chachami, Georgia, Chevet, Eric, Clague, Michael J., Dantuma, Nico, Rankov, Aleksandra Divac, Galdeano, Carles, Giglione, Carmela, Glickman, Michael H., Lalmanach, Gilles, Lindon, Catherine, Matthiesen, Rune, Meroni, Germana, Pick, Elah, Poidevin, Laetitia, Rivas, Carmen, Rodriguez, Manuel S., Sammler, Esther, Shiber, Ayala, Skoulakis, Efthimios M.C., Stein, Matthias, Vertegaal, Alfred C.O., Coux, Olivier, and Farràs, Rosa

Published
2024
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46. Endoscopic ultrasound-guided drainage of pancreatic collections with dedicated metal stents: A nationwide, multicenter, propensity score-matched comparison

Author

Binda, Cecilia, Petrone, Maria Chiara, Berretti, Debora, Macchiarelli, Raffaele, Lovera, Mauro, Attili, Fabia, D'Errico, Francesca, Brancaccio, Mario Luciano, Redaelli, Alessandro, Tasini, Enrico, Ballarè, Marco, Coppola, Franco, Leone, Nicola, Grassia, Roberto, Fusaroli, Pietro, DeAngelis, Claudio, Cipolletta, Fabio, Manno, Mauro, Badas, Roberta, Pollino, Valeria, Camellini, Lorenzo, Bernardoni, Laura, Conte, Elisabetta, Lisotti, Andrea, Mutignani, Massimiliano, Traina, Mario, Arcidiacono, Paolo Giorgio, Coluccio, Chiara, Facciorusso, Antonio, Forti, Edoardo, De Nucci, Germana, Mitri, Roberto Di, Togliani, Thomas, Cugia, Luigi, Ofosu, Andrew, Anderloni, Andrea, Tarantino, Ilaria, Fabbri, Carlo, and Crinò, Stefano Francesco

Published
2024
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47. Co-occurrence of Overweight, Stunting, and Anemia among Adolescents (10–19 Years) in Tanzania Mainland: A School-Based Cross-Sectional Study

Author

Mchau, Geofrey, Killel, Erick, Azizi, Kaunara, Henry, Stanslaus, Ainan, Samafilan, Jumbe, Theresia, Bundara, Nyamizi, Kystikila, Wiggins, Mwingira, Felista, Machafuko, Pendael, Wilson, Bwire, Paulo, Heavenlight A., Epimack, Sauli, Mshinda, Hoyce, Chacky, Frank, Noor, Ramadhani, Masumo, Ray, and Leyna, Germana

Published
2024
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48. Urn models with random multiple drawing and random addition

Author

Crimaldi, Irene, Louis, Pierre-Yves, and Minelli, Ida Germana

Subjects
Mathematics - Probability, Mathematics - Statistics Theory, 60B10, 60F05, 60F15, 60G42, 62P25, 91D30, 92C60
Abstract

We consider an urn model with multiple drawing and random time-dependent addition matrix. The model is very general with respect to previous literature: the number of sampled balls at each time-step is random, the addition matrix has general random entries. For the proportion of balls of a given color, we prove almost sure convergence results and fluctuation theorems (through CLTs in the sense of stable convergence and of almost sure conditional convergence, which are stronger than convergence in distribution). Asymptotic confidence intervals are given for the limit proportion, whose distribution is generally unknown.

Published
2021

49. Urtica dioica Extract Abrogates Chlorpyrifos-Induced Toxicity in Zebrafish Larvae

Author

Kamel Mhalhel, Yassine Kadmi, Ahlem Ben Chira, Maria Levanti, Lidia Pansera, Marzio Cometa, Mirea Sicari, Antonino Germanà, Marialuisa Aragona, and Giuseppe Montalbano

Subjects
Urtica dioica, nettle, chlorpyrifos, organophosphate pesticides, developmental toxicity, neuroprotection, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Chlorpyrifos (CPF) is a widely used organophosphate insecticide, though its excessive use causes environmental contamination, raising concerns about its adverse effects on human health. In this regard, Urtica dioica stands out as a promising candidate for counteracting chemical ‘contaminant’ toxicity thanks to its therapeutic properties. Therefore, our study aimed to investigate the potential of an Urtica dioica ethanolic extract (UDE) to mitigate chlorpyrifos-induced toxicity. Eight compounds in the Urtica dioica ethanolic extract have been identified, most of which present significant potential as antioxidant, anti-inflammatory, and neuroprotective agents. Chlorpyrifos exposure altered hatching rates, increased the incidence of teratogenic effects, and upregulated the expression of brain-derived neurotrophic factor (Bdnf) in zebrafish larvae telencephalon. On the other hand, UDE demonstrated a preventive effect against CPF-induced teratogenicity, which is expressed by a lower morphological deformity rate. Moreover, the UDE showed a rather protective effect, maintaining the physiological condition of the telencephalon. Additionally, CPF altered the locomotor behavior of larvae, which was characterized by irregular swimming and increased activity. This defective behavioral pattern was slightly attenuated by the UDE. Our findings suggest that the UDE possesses significant protective properties against CPF-induced toxicity, probably conferred by its natural antioxidant and anti-inflammatory contents. Still, further research is needed to elucidate the recruited mechanisms and implicated pathways on UDE’s protective effects.

Published
2024
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50. Programmed Cell Death Ligand 1 (PD-L1) Immunohistochemical Expression in Advanced Urothelial Bladder Carcinoma: An Updated Review with Clinical and Pathological Implications

Author

Emanuela Germanà, Ludovica Pepe, Cristina Pizzimenti, Mariagiovanna Ballato, Francesco Pierconti, Giovanni Tuccari, Antonio Ieni, Giuseppe Giuffrè, Guido Fadda, Vincenzo Fiorentino, and Maurizio Martini

Subjects
bladder carcinoma, immune system, PD-1/PD-L1 axis, immunotherapy, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

The management of advanced bladder carcinoma involves a multidisciplinary approach, but the prognosis remains poor for many patients. The immune system plays a crucial role in this disease, influencing both tumor development and response to treatment, and exploiting the immune system against the tumor can be a valuable strategy to destroy neoplastic cells. This is the biological principle underlying Bacillus Calmette–Guérin (BCG) use and, more recently, immune checkpoint inhibitors (ICIs), like PD-1 (programmed death-1)/PD-L1 (programmed death-ligand 1) inhibitors. In fact, one of the best studied immune checkpoints is represented by the PD-1/PD-L1 axis, which is a well-known immune escape system adopted by neoplastic bladder cells. PD-L1 expression has been associated with a higher pathologic stage and has shown prognostic value in bladder carcinoma. Interestingly, high-grade bladder cancers tend to express higher levels of PD-1 and PD-L1, suggesting a potential role of such an axis in mediating disease progression. Immunotherapy with PD-1 and PD-L1 inhibitors has therefore emerged as a valuable treatment option and has shown efficacy in advanced bladder cancer patients, with high PD-L1 expression levels associated with better treatment responses. Our review aims to provide a comprehensive overview of the role of PD-L1 in advanced bladder cancer, focusing on its implications for treatment decisions and the prediction of treatment response. Overall, our work aims to contribute to the understanding of PD-L1 as a predictive biomarker and highlight its role in shaping therapeutic approaches for advanced bladder cancer.

Published
2024
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