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12 results on '"Gerlach, Tilman J"'

6. Hepatitis C virus eradication associated with hepatitis B virus superinfection and development of a hepatitis B virus specific T cell response

Author

Gruener, Norbert H, primary, Jung, Maria-Christina, additional, Ulsenheimer, Axel, additional, Gerlach, Tilman J, additional, Diepolder, Helmut M, additional, Schirren, Carl A, additional, Hoffmann, Robert, additional, Wächtler, Martin, additional, Backmund, Markus, additional, and Pape, Gerd R, additional

Published
2002
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7. Association of Hepatitis C Virus–Specific CD8+T Cells with Viral Clearance in Acute Hepatitis C

Author

Grüner, Norbert H., primary, Gerlach, Tilman J., additional, Jung, Maria‐Christina, additional, Diepolder, Helmut M., additional, Schirren, Carl Albrecht, additional, Schraut, Winfried W., additional, Hoffmann, Robert, additional, Zachoval, Reinhart, additional, Santantonio, Teresa, additional, Cucchiarini, M., additional, Cerny, Andreas, additional, and Pape, Gerd R., additional

Published
2000
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8. A Genetic Validation Study Reveals a Role of Vitamin D Metabolism in the Response to Interferon-Alfa-Based Therapy of Chronic Hepatitis C.

Author

Lange, Christian M., Bibert, Stephanie, Kutalik, Zoltan, Burgisser, Philippe, Cerny, Andreas, Dufour, Jean- Francois, Geier, Andreas, Gerlach, Tilman J., Heim, Markus H., Malinverni, Raffaele, Negro, Francesco, Regenass, Stephan, Badenhoop, Klaus, Bojunga, Jörg, Sarrazin, Christoph, Zeuzem, Stefan, Müller, Tobias, Berg, Thomas, Bochud, Pierre-Yves, and Moradpour, Darius

Subjects
HEPATITIS C, VITAMIN D, GENETIC polymorphisms, METABOLISM, INTERFERONS, CHRONIC diseases
Abstract

Background: To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-a-based therapy of chronic hepatitis C. Methodology/Principal Findings: Associations between a functionally relevant polymorphism in the gene encoding the vitamin D 1α-hydroxylase (CYP27B1-1260 rs10877012) and the response to treatment with pegylated interferon-α (PEG-IFN-α) and ribavirin were determined in 701 patients with chronic hepatitis C. In addition, associations between serum concentrations of 25-hydroxyvitamin D3 (25[OH]D3) and treatment outcome were analysed. CYP27B1-1260 rs10877012 was found to be an independent predictor of sustained virologic response (SVR) in patients with poor-response IL28B genotypes (15% difference in SVR for rs10877012 genotype AA vs. CC, p = 0.02, OR = 1.52, 95% CI = 1.061-2.188), but not in patients with favourable IL28B genotype. Patients with chronic hepatitis C showed a high prevalence of vitamin D insufficiency (25[OH]D3<20 ng/mL) during all seasons, but 25(OH)D3 serum levels were not associated with treatment outcome. Conclusions/Significance: Our study suggests a role of bioactive vitamin D (1,25[OH]2D3, calcitriol) in the response to treatment of chronic hepatitis C. However, serum concentration of the calcitriol precursor 25(OH)D3 is not a suitable predictor of treatment outcome. [ABSTRACT FROM AUTHOR]

Published
2012
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9. A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C

Author

Bibert, Stephanie, Kutalik, Zoltan, Gerlach, Tilman J, Lange, Christian M, Dufour, Jean-François, Burgisser, Philippe, Badenhoop, Klaus, Bochud, Pierre-Yves, Bojunga, Jörg, Cerny, Andreas, Negro, Francesco, Moradpour, Darius, Malinverni, Raffaele, Heim, Markus H, Swiss Hepatitis C Cohort Study Group, Berg, Thomas, Geier, Andreas, Müller, Tobias, Sarrazin, Christoph, Regenass, Stephan, and Zeuzem, Stefan

Subjects
3. Good health
Abstract

Background To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C. Methodology/Principal Findings Associations between a functionally relevant polymorphism in the gene encoding the vitamin D 1α-hydroxylase (CYP27B1-1260 rs10877012) and the response to treatment with pegylated interferon-α (PEG-IFN-α) and ribavirin were determined in 701 patients with chronic hepatitis C. In addition, associations between serum concentrations of 25-hydroxyvitamin D3 (25[OH]D3) and treatment outcome were analysed. CYP27B1-1260 rs10877012 was found to be an independent predictor of sustained virologic response (SVR) in patients with poor-response IL28B genotypes (15% difference in SVR for rs10877012 genotype AA vs. CC, p = 0.02, OR = 1.52, 95% CI = 1.061–2.188), but not in patients with favourable IL28B genotype. Patients with chronic hepatitis C showed a high prevalence of vitamin D insufficiency (25[OH]D3

10. Association of Hepatitis C Virus—Specific CD8+ T Cells with Viral Clearance in Acute Hepatitis C

Author

Grüner, Norbert H., Gerlach, Tilman J., Jung, Maria-Christina, Diepolder, Helmut M., Schirren, Carl Albrecht, Schraut, Winfried W., Hoffmann, Robert, Zachoval, Reinhart, Santantonio, Teresa, Cucchiarini, M., Cerny, Andreas, Pape, Gerd R., Grüner, Norbert H., Gerlach, Tilman J., Jung, Maria-Christina, Diepolder, Helmut M., Schirren, Carl Albrecht, Schraut, Winfried W., Hoffmann, Robert, Zachoval, Reinhart, Santantonio, Teresa, Cucchiarini, M., Cerny, Andreas, and Pape, Gerd R.

Abstract

CD8+ T lymphocytes play a major role in antiviral immune defense. Their significance for acute hepatitis C is unclear. Our aim was to correlate the CD8+ T cell response with the outcome of infection. Eighteen patients with acute hepatitis C and 19 normal donors were studied. Hepatitis C virus (HCV)—specific CD8+ T cells were identified in the enzyme-linked immunospot assay by their interferon-γ (IFN-γ) production after specific stimulation. The highest numbers of IFN-γ—producing HCV-specific CD8+ T cells were found in patients with acute hepatitis C and a self-limited course of disease during the first 6 months after onset of disease, but these numbers dropped thereafter to undetectable levels. The differences in responsiveness between patients with self-limited disease versus patients with a chronic course were statistically significant (P < .001). Our data show that the number of IFN—γ-producing HCV-specific CD8+ T cells during the first 6 months after onset of disease is associated with eradication of the HCV infection

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