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3. The prognostic impact of different tumor marker levels in nonseminomatous germ cell tumor patients with intermediate prognosis: A registry of the International Global Germ Cell Tumor Collaborative Group (G3)

Author

Seidel, Christoph, Daugaard, Gedske, Tryakin, Alexey, Necchi, Andrea, Cohn-Cedermark, Gabriella, Ståhl, Olof, Hentrich, Marcus, Brito, Margarida, Albany, Costantine, Taza, Fadi, Gerl, Arthur, Oechsle, Karin, Oing, Christoph, and Bokemeyer, Carsten

Published
2019
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4. European Consensus Conference on Diagnosis and Treatment of Germ Cell Cancer: A Report of the Second Meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): Part II

Author

Krege, Susanne, Beyer, Jörg, Souchon, Rainer, Albers, Peter, Albrecht, Walter, Algaba, Ferran, Bamberg, Michael, Bodrogi, István, Bokemeyer, Carsten, Cavallin-Ståhl, Eva, Classen, Johannes, Clemm, Christoph, Cohn-Cedermark, Gabriella, Culine, Stéphane, Daugaard, Gedske, De Mulder, Pieter H.M., De Santis, Maria, de Wit, Maike, de Wit, Ronald, Derigs, Hans Günter, Dieckmann, Klaus-Peter, Dieing, Annette, Droz, Jean-Pierre, Fenner, Martin, Fizazi, Karim, Flechon, Aude, Fosså, Sophie D., Garcia del Muro, Xavier, Gauler, Thomas, Geczi, Lajos, Gerl, Arthur, Germa-Lluch, Jose Ramon, Gillessen, Silke, Hartmann, Jörg T., Hartmann, Michael, Heidenreich, Axel, Hoeltl, Wolfgang, Horwich, Alan, Huddart, Robert, Jewett, Michael, Joffe, Johnathan, Jones, William G., Kisbenedek, László, Klepp, Olbjørn, Kliesch, Sabine, Koehrmann, Kai Uwe, Kollmannsberger, Christian, Kuczyk, Markus, Laguna, Pilar, Leiva Galvis, Oscar, Loy, Volker, Mason, Malcolm D., Mead, Graham M., Mueller, Rolf, Nichols, Craig, Nicolai, Nicola, Oliver, Tim, Ondrus, Dalibor, Oosterhof, Gosse O.N., Paz-Ares, Luis, Pizzocaro, Giorgio, Pont, Jörg, Pottek, Tobias, Powles, Tom, Rick, Oliver, Rosti, Giovanni, Salvioni, Roberto, Scheiderbauer, Jutta, Schmelz, Hans-Ulrich, Schmidberger, Heinz, Schmoll, Hans-Joachim, Schrader, Mark, Sedlmayer, Felix, Skakkebaek, Niels E., Sohaib, Aslam, Tjulandin, Sergei, Warde, Padraig, Weinknecht, Stefan, Weissbach, Lothar, Wittekind, Christian, Winter, Eva, Wood, Lori, and von der Maase, Hans

Published
2008
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9. The prognostic impact of different tumor marker levels in nonseminomatous germ cell tumor patients with intermediate prognosis:A registry of the International Global Germ Cell Tumor Collaborative Group (G3)

Author

Seidel, Christoph, Daugaard, Gedske, Tryakin, Alexey, Necchi, Andrea, Cohn-Cedermark, Gabriella, Ståhl, Olof, Hentrich, Marcus, Brito, Margarida, Albany, Costantine, Taza, Fadi, Gerl, Arthur, Oechsle, Karin, Oing, Christoph, Bokemeyer, Carsten, Seidel, Christoph, Daugaard, Gedske, Tryakin, Alexey, Necchi, Andrea, Cohn-Cedermark, Gabriella, Ståhl, Olof, Hentrich, Marcus, Brito, Margarida, Albany, Costantine, Taza, Fadi, Gerl, Arthur, Oechsle, Karin, Oing, Christoph, and Bokemeyer, Carsten

Abstract

Background: Germ cell tumor patients with intermediate prognosis (IPGCT) according to the International Germ Cell Cancer Collaborative Group (IGCCCG) classification represent a heterogeneous group with different clinical features. This analysis was performed to investigate the prognostic impact of different tumor marker levels prior to first line chemotherapy within IPGCT. Methods: For this study an international registry for IPGCT was established. Eligibility criteria were intermediate prognosis according to IGCCCG criteria, nonseminomatous histology, male sex, and age ≥ 16 years. Uni- and multivariate analysis were conducted to identify characteristics associated with survival outcomes. Receiver-Operating-Characteristic curve analysis was applied to find cut-off parameters. Five-year overall survival (OS) rate was the primary and 5-year progression-free survival rate the secondary endpoint. Results: This database included 634 IPGCT with a median follow-up of 9.0 years (interquartile range: 14.35). Patients received first line treatment with platinum based chemotherapy, associated with a 5-year OS rate of 87%. The stratification of patients according to AFP levels revealed a correlation between AFP levels and outcome, associated with 5-year OS rates of 88% for AFP levels <1,000 IU/ml (n = 303), 89% for 1,000 to 2,000 IU/ml (n = 82), 87% for >2,000 to 6,000 IU/ml (n = 121), and 82% for >6,000 IU/ml (n = 57) prior first course of chemotherapy, respectively (P= 0.013). LDH levels prior fist course of chemotherapy also correlated with outcome associated with 5-year OS rates of 92% for <2 UNL (n = 271), 89% for ≥2 to 3 UNL (n = 85), 78% for >3 to 4 UNL (n = 34), and 77% for >4 UNL (n = 79), respectively (P= 0.03). Different HCG levels prior chemotherapy were not associated with outcome. In multivariable analysis AFP levels >6,000 IU/ml (P= 0.023; hazard ratio HR 2.263) or >1,982 IU/ml (P= 0.031; HR 1.722), and LDH levels >3 UNL (P< 0.001

Published
2019

14. Viable Malignant Cells After Primary Chemotherapy for Disseminated Nonseminomatous Germ Cell Tumors: Prognostic Factors and Role of Postsurgery Chemotherapy—Results From an International Study Group

Author

Fizazi, Karim, Tjulandin, Sergei, Salvioni, Roberto, Germà-Lluch, José R., Bouzy, Jeannine, Ragan, David, Bokemeyer, Carsten, Gerl, Arthur, Fléchon, Aude, de Bono, Johann S., Stenning, Sally, Horwich, Alan, Pont, Jörg, Albers, Peter, De Giorgi, Ugo, Bower, Mark, Bulanov, Anatoly, Pizzocaro, Giorgio, Aparicio, Jorge, Nichols, Craig R., Théodore, Christine, Hartmann, Jörg Thomas, Schmoll, Hans-Joachim, Kaye, Stanley B., Culine, Stéphane, Droz, Jean-Pierre, and Mahé, Cedric

Published
2001

23. Intermediate prognosis in metastatic germ cell tumors (IPGCT): Outcome and prognostic factors.

Author

Seidel, Christoph Alexander, primary, Daugaard, Gedske, additional, Tryakin, Alexey, additional, Necchi, Andrea, additional, Hentrich, Marcus, additional, Cohn-Cedermark, Gabriella Elisabeth, additional, Stahl, Olof, additional, Goncalves, Margarida Brito, additional, Gerl, Arthur, additional, Oechsle, Karin, additional, and Bokemeyer, Carsten, additional

Published
2017
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24. Testicular cancer and Hodgkin disease in the same patient

Author

Gerl, Arthur, Clemm, Christoph, Salat, Christoph, Mittermuller, Johann, Bomfleur, Wolfgang, and Wilmanns, Wolfgang

Subjects
Hodgkin's disease -- Complications, Testicular cancer -- Diagnosis, Germ cell tumors -- Physiological aspects, Chorionic gonadotropin -- Measurement, Alpha fetoproteins -- Measurement, Health
Abstract

Background. Although testicular cancer and Hodgkin disease are the neoplasms with the highest incidence in young men, only 13 cases of metachronous and 2 cases of synchronous occurrence in the same person were reported before 1991. Methods. A 30-year-old man is described, in whom, 2 years after radiation therapy for Stage IIIA Hodgkin disease, a testicular nonseminomatous germ cell tumor developed with metastatic spread to the retroperitoneal lymph nodes, lung, and left supraclavicular fossa. The second case report describes a 31-year-old man in whom a metastasizing nonseminomatous testicular cancer, with elevation of levels of the serum tumor markers alpha-fetoprotein and human chorionic gonadotropin, developed simultaneously with axillary lymphadenopathy that was histologically confirmed Hodgkin disease. Results. After five cycles of cisplatin-based chemotherapy and secondary retroperitoneal lymphadenectomy, the patient with metachronous disease has remained in complete remission for 8 years. The patient with synchronous occurrence has been disease-free for 14 months after five cycles of chemotherapy consisting of cisplatin, etoposide, and doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH). Conclusions. The metachronous and synchronous occurrence of testicular cancer and Hodgkin disease is a rare association of two curable neoplasms. The presence of both malignant neoplasms should be taken into consideration in young male patients, especially if disease distribution diverges from a regular pattern. Cancer 1993; 71:2838-40.

Published
1993

27. European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I

Author

Krege, Susanne, Beyer, Jörg, Souchon, Rainer, Albers, Peter, Albrecht, Walter, Algaba, Ferran, Bamberg, Michael, Bodrogi, István, Bokemeyer, Carsten, Cavallin-Ståhl, Eva, Classen, Johannes, Clemm, Christoph, Cohn-Cedermark, Gabriella, Culine, Stéphane, Daugaard, Gedske, De Mulder, Pieter H M, De Santis, Maria, de Wit, Maike, de Wit, Ronald, Derigs, Hans Günter, Dieckmann, Klaus-Peter, Dieing, Annette, Droz, Jean-Pierre, Fenner, Martin, Fizazi, Karim, Flechon, Aude, Fosså, Sophie D, del Muro, Xavier Garcia, Gauler, Thomas, Geczi, Lajos, Gerl, Arthur, Germa-Lluch, Jose Ramon, Gillessen, Silke, Hartmann, Jörg T, Hartmann, Michael, Heidenreich, Axel, Hoeltl, Wolfgang, Horwich, Alan, Huddart, Robert, Jewett, Michael, Joffe, Johnathan, Jones, William G, Kisbenedek, László, Klepp, Olbjørn, Kliesch, Sabine, Koehrmann, Kai Uwe, Kollmannsberger, Christian, Kuczyk, Markus, Laguna, Pilar, Galvis, Oscar Leiva, Loy, Volker, Mason, Malcolm D, Mead, Graham M, Mueller, Rolf, Nichols, Craig, Nicolai, Nicola, Oliver, Tim, Ondrus, Dalibor, Oosterhof, Gosse O N, Ares, Luis Paz, Pizzocaro, Giorgio, Pont, Jörg, Pottek, Tobias, Powles, Tom, Rick, Oliver, Rosti, Giovanni, Salvioni, Roberto, Scheiderbauer, Jutta, Schmelz, Hans-Ulrich, Schmidberger, Heinz, Schmoll, Hans-Joachim, Schrader, Mark, Sedlmayer, Felix, Skakkebaek, Niels E, Sohaib, Aslam, Tjulandin, Sergei, Warde, Padraig, Weinknecht, Stefan, Weissbach, Lothar, Wittekind, Christian, Winter, Eva, Wood, Lori, von der Maase, Hans, Krege, Susanne, Beyer, Jörg, Souchon, Rainer, Albers, Peter, Albrecht, Walter, Algaba, Ferran, Bamberg, Michael, Bodrogi, István, Bokemeyer, Carsten, Cavallin-Ståhl, Eva, Classen, Johannes, Clemm, Christoph, Cohn-Cedermark, Gabriella, Culine, Stéphane, Daugaard, Gedske, De Mulder, Pieter H M, De Santis, Maria, de Wit, Maike, de Wit, Ronald, Derigs, Hans Günter, Dieckmann, Klaus-Peter, Dieing, Annette, Droz, Jean-Pierre, Fenner, Martin, Fizazi, Karim, Flechon, Aude, Fosså, Sophie D, del Muro, Xavier Garcia, Gauler, Thomas, Geczi, Lajos, Gerl, Arthur, Germa-Lluch, Jose Ramon, Gillessen, Silke, Hartmann, Jörg T, Hartmann, Michael, Heidenreich, Axel, Hoeltl, Wolfgang, Horwich, Alan, Huddart, Robert, Jewett, Michael, Joffe, Johnathan, Jones, William G, Kisbenedek, László, Klepp, Olbjørn, Kliesch, Sabine, Koehrmann, Kai Uwe, Kollmannsberger, Christian, Kuczyk, Markus, Laguna, Pilar, Galvis, Oscar Leiva, Loy, Volker, Mason, Malcolm D, Mead, Graham M, Mueller, Rolf, Nichols, Craig, Nicolai, Nicola, Oliver, Tim, Ondrus, Dalibor, Oosterhof, Gosse O N, Ares, Luis Paz, Pizzocaro, Giorgio, Pont, Jörg, Pottek, Tobias, Powles, Tom, Rick, Oliver, Rosti, Giovanni, Salvioni, Roberto, Scheiderbauer, Jutta, Schmelz, Hans-Ulrich, Schmidberger, Heinz, Schmoll, Hans-Joachim, Schrader, Mark, Sedlmayer, Felix, Skakkebaek, Niels E, Sohaib, Aslam, Tjulandin, Sergei, Warde, Padraig, Weinknecht, Stefan, Weissbach, Lothar, Wittekind, Christian, Winter, Eva, Wood, Lori, and von der Maase, Hans

Abstract

OBJECTIVES: The first consensus report presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in the year 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, Amsterdam, The Netherlands. METHODS: Medical oncologists, urological surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference, and incorporated the new data into updated and revised guidelines. As for the first meeting, the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. RESULTS: The first part of the consensus paper describes the clinical presentation of the primary tumor, its treatment, the importance and treatment of testicular intraepithelial neoplasia (TIN), histological classification, staging and prognostic factors, and treatment of stage I seminoma and non-seminoma. CONCLUSIONS: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early- and advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged Udgivelsesdato: 2008/3

Published
2007

31. Corrigendum to: “European Consensus Conference on Diagnosis and Treatment of Germ Cell Cancer: A Report of the Second Meeting of the European Germ Cell Cancer Consensus group (EGCCCG): Part I” [Eur Urol 2008;53:478–96] and to: “European Consensus Conference on Diagnosis and Treatment of Germ Cell Cancer: A Report of the Second Meeting of the European Germ Cell Cancer Consensus group (EGCCCG): Part II” [Eur Urol 2008;53:497–513]

Author

Krege, Susanne, primary, Beyer, Jörg, additional, Souchon, Rainer, additional, Albers, Peter, additional, Albrecht, Walter, additional, Algaba, Ferran, additional, Bamberg, Michael, additional, Bodrogi, István, additional, Bokemeyer, Carsten, additional, Cavallin-Ståhl, Eva, additional, Classen, Johannes, additional, Clemm, Christoph, additional, Cohn-Cedermark, Gabriella, additional, Culine, Stéphane, additional, Daugaard, Gedske, additional, De Mulder, Pieter H.M., additional, De Santis, Maria, additional, de Wit, Maike, additional, de Wit, Ronald, additional, Derigs, Hans Günter, additional, Dieckmann, Klaus-Peter, additional, Dieing, Annette, additional, Droz, Jean-Pierre, additional, Fenner, Martin, additional, Fizazi, Karim, additional, Flechon, Aude, additional, Fosså, Sophie D., additional, Garcia del Muro, Xavier, additional, Gauler, Thomas, additional, Geczi, Lajos, additional, Gerl, Arthur, additional, Germa-Lluch, Jose Ramon, additional, Gillessen, Silke, additional, Hartmann, Jörg T., additional, Hartmann, Michael, additional, Heidenreich, Axel, additional, Hoeltl, Wolfgang, additional, Horwich, Alan, additional, Huddart, Robert, additional, Jewett, Michael, additional, Joffe, Johnathan, additional, Jones, William G., additional, Kisbenedek, László, additional, Klepp, Olbjørn, additional, Kliesch, Sabine, additional, Koehrmann, Kai Uwe, additional, Kollmannsberger, Christian, additional, Kuczyk, Markus, additional, Laguna, Pilar, additional, Galvis, Oscar Leiva, additional, Loy, Volker, additional, Mason, Malcolm D., additional, Mead, Graham M., additional, Mueller, Rolf, additional, Nichols, Craig, additional, Nicolai, Nicola, additional, Oliver, Tim, additional, Ondrus, Dalibor, additional, Oosterhof, Gosse O.N., additional, Ares, Luis Paz, additional, Pizzocaro, Giorgio, additional, Pont, Jörg, additional, Pottek, Tobias, additional, Powles, Tom, additional, Rick, Oliver, additional, Rosti, Giovanni, additional, Salvioni, Roberto, additional, Scheiderbauer, Jutta, additional, Schmelz, Hans-Ulrich, additional, Schmidberger, Heinz, additional, Schmoll, Hans-Joachim, additional, Schrader, Mark, additional, Sedlmayer, Felix, additional, Skakkebaek, Niels E., additional, Sohaib, Aslam, additional, Tjulandin, Sergei, additional, Warde, Padraig, additional, Weinknecht, Stefan, additional, Weissbach, Lothar, additional, Wittekind, Christian, additional, Winter, Eva, additional, Wood, Lori, additional, and von der Maase, Hans, additional

Published
2008
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32. Phase I/II Study of Sequential Dose-Intensified Ifosfamide, Cisplatin, and Etoposide Plus Paclitaxel As Induction Chemotherapy for Poor Prognosis Germ Cell Tumors by the German Testicular Cancer Study Group

Author

Hartmann, Jörg T., primary, Gauler, Thomas, additional, Metzner, Bernd, additional, Gerl, Arthur, additional, Casper, Jochen, additional, Rick, Oliver, additional, Horger, Marius, additional, Schleicher, Jan, additional, Derigs, Günter, additional, Mayer-Steinacker, Regine, additional, Beyer, Jörg, additional, Kuczyk, Markus A., additional, and Bokemeyer, Carsten, additional

Published
2007
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34. Extragonadal seminoma

Author

Bokemeyer, Carsten, primary, Droz, Jean-P., additional, Horwich, Alan, additional, Gerl, Arthur, additional, Fossa, Sophie D., additional, Beyer, J�rg, additional, Pont, J�rg, additional, Schmoll, Hans-J., additional, Kanz, Lothar, additional, Einhorn, Lawrence, additional, Nichols, Craig R., additional, and Hartmann, J�rg T., additional

Published
2001
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36. Retroperitoneal Metastases in Testicular Cancer: Role of CT Measurements of Residual Masses in Decision Making for Resection after Chemotherapy

Author

Steyerberg, Ewout W., primary, Keizer, H. Jan, additional, Sleijfer, Dirk T., additional, Fosså, Sophie D., additional, Bajorin, Dean F., additional, Gerl, Arthur, additional, de Wit, Ronald, additional, Kirkels, Wim J., additional, Koops, Heimen Schraffordt, additional, and Habbema, J. Dik F., additional

Published
2000
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45. Urinary Excretion of Platinum in Chemotherapy-treated Long-term Survivors of Testicular Cancer.

Author

Gerl, Arthur and Schierl, Rudolf

Subjects
*PLATINUM, *TESTICULAR cancer
Abstract

As the majority of patients with metastatic testicular cancer are cured by cisplatin-based chemotherapy and can expect an additional life span of around 50 years, late toxicity is of particular relevance. Urine and serum concentrations of platinum were determined by voltammetry in 37 patients at 5.3 to 16.8 years after cisplatin-based chemotherapy. Urinary excretion and serum levels of platinum were 100 to 1000 times higher in patients than in unexposed controls. There may be an association between platinum storage and endocrinologic and metabolic late sequelae, as well as a risk of second cancer. However, further research is necessary to clarify the biological relevance of long-term storage of platinum. [ABSTRACT FROM AUTHOR]

Published
2000
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