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1,173 results on '"Gerke, Oke"'

1. Identifying the primary tumour in patients with cancer of unknown primary (CUP) using [18F]FDG PET/CT: a systematic review and individual patient data meta-analysis

Author

Willemse, Jeroen R. J., Lambregts, Doenja M. J., Balduzzi, Sara, Schats, Winnie, Snaebjornsson, Petur, Marchetti, Serena, Vollebergh, Marieke A., van Golen, Larissa W., Cheung, Zing, Vogel, Wouter V., Bodalal, Zuhir, Rostami, Sajjad, Gerke, Oke, Sivakumaran, Tharani, Beets-Tan, Regina G.H., and Lahaye, Max J.

Published
2024
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34. Organ-specific accuracy of [18F]FDG-PET/CT in identifying immune-related adverse events in patients with high-risk melanoma treated with adjuvant immune checkpoint inhibitor.

Author

Gideonse, Birte Molvik, Birkeland, Magnus, Vilstrup, Mie Holm, Grupe, Peter, Naghavi-Behzad, Mohammad, Ruhlmann, Christina H., Gerke, Oke, and Hildebrandt, Malene Grubbe

Abstract

Purpose: This study aimed to determine the organ-specific accuracy of [18F]FDG-PET/CT in identifying immune-related adverse events (irAEs) in patients with high-risk (stage III/IV) surgically resected melanoma treated with an adjuvant immune checkpoint inhibitor (ICI) and determine the incidence of irAEs within the first year after starting treatment. Materials and methods: This registry-based study included individuals who had undergone surgical removal of melanoma and were undergoing adjuvant ICI treatment (either nivolumab or pembrolizumab). The study specifically enrolled patients who had undergone both a baseline and at least one subsequent follow-up [18F]FDG-PET/CT scan. Follow-up scans were performed every third month in the first year after surgery to screen for disease recurrence. We retrospectively compared the follow-up scans with baseline scans to identify irAEs. Clinical information on irAEs was obtained from medical records and served as a reference standard for determining the accuracy of [18F]FDG-PET/CT. Results: A total of 123 patients with 363 [18F]FDG-PET/CT scans were included, and 65 patients (52.8%) developed irAEs. In decreasing order, the organ-specific incidences of irAEs were: skin 26/65 (40%), muscle and joints 21/65 (32.3%), intestines 13/65 (20%), thyroid gland 12/65 (18.5%), lungs 4/65 (6.2%), and heart 2/65 (3.1%). The sensitivities and specificities of [18F]FDG-PET/CT for diagnosing irAEs were: skin 19% (95% CI: 7–39%) and 95% (88–98%), muscles and joints 71% (48–89%) and 83% (75–90%), intestines 100% (75–100%) and 85% (77–91%); thyroid gland 92% (62–99%) and 95% (89–98%), lungs 75% (19–99%) and 90% (83–95%), and heart 50% (13–99%) and 97% (92–99%), respectively. Conclusion: [18F]FDG-PET/CT generally had moderate to high sensitivities (except for skin and heart) and specificities in diagnosing irAEs in patients receiving adjuvant ICI; this could be suggested to be systematically assessed and reported in scan reports. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Ultrasound in the Diagnosis of Non-Expandable Lung: A Prospective Observational Study of M-Mode, B-Mode, and 2D-Shear Wave Elastography

Author

Petersen, Jesper Koefod, primary, Fjaellegaard, Katrine, additional, Rasmussen, Daniel B., additional, Alstrup, Gitte, additional, Høegholm, Asbjørn, additional, Sidhu, Jatinder Singh, additional, Sivapalan, Pradeesh, additional, Gerke, Oke, additional, Bhatnagar, Rahul, additional, Clementsen, Paul Frost, additional, Laursen, Christian B., additional, and Bodtger, Uffe, additional

Published
2024
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