113 results on '"Gerhard Rücker"'
Search Results
2. Screening of brazilian plants for the presence of peroxides
- Author
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D. Manns, Berta Maria Heinzmann, Miriam Falkenberg, Sérgio Augusto de Loreto Bordignon, Marcos Sobral, Nelson Ivo Matzenbacher, Eloir Pedro Schenkel, Gerhard Rücker, and Lilian Auler Mentz
- Subjects
Pharmacology ,chemistry.chemical_compound ,Chloroform ,chemistry ,Reagent ,Botany ,Plant species ,Pharmaceutical Science ,Biology ,Asteraceae ,biology.organism_classification ,Dichloromethane - Abstract
Chloroform or dichloromethane extracts of 357 southern Brazilian plant species were tested for the presence of peroxides by thinlayer chromatography, using the spray reagent from Huber & Frohlke. From the species tested, 71 (20%) showed positive results and most of them (56%) are Asteraceae species. The species tested were mainly from Asteraceae, but 55 more families were screened, in a total of 77 genera surveyed.
- Published
- 2002
3. Screening of brazilian plants for the presence of peroxides Investigação de plantas brasileiras quanto à presença de peróxidos
- Author
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Eloir Pedro Schenkel, Gerhard Rücker, Detlef Manns, Miriam B. Falkenberg, Nelson I. Matzenbacher, Marcos Sobral, Lilian A. Mentz, Sérgio A.L. Bordignon, and Berta M. Heinzmann
- Subjects
lcsh:Pharmacy and materia medica ,Peróxidos ,lcsh:R ,lcsh:Medicine ,lcsh:RS1-441 ,Asteraceae ,Atividade antimalárica ,Peroxides ,Antimalarial activity - Abstract
Chloroform or dichloromethane extracts of 357 southern Brazilian plant species were tested for the presence of peroxides by thinlayer chromatography, using the spray reagent from Huber & Fröhlke. From the species tested, 71 (20%) showed positive results and most of them (56%) are Asteraceae species. The species tested were mainly from Asteraceae, but 55 more families were screened, in a total of 77 genera surveyed.Extratos clorofórmicos ou diclorometânicos de 357 espécies vegetais de ocorrência no sul do Brasil foram testados quanto à presença de peróxidos, através de cromatografia em camada delgada, utilizando o reagente de detecção de Huber & Fröhlke. Das espécies testadas, 71 (20%) apresentaram resultado positivo, a maioria delas (56%) pertencentes à família Asteraceae. A maioria das espécies testadas pertencia a Asteraceae, mas outras 55 famílias foram também testadas, abrangendo um total de 77 gêneros.
- Published
- 2002
4. Synthese der β-D-Glucuronide der O-Desmethyl-Metaboliten des Tramadols: Synthesis of β-D-Glucuronides of O-Demethyl-Metabolites of Tramadol
- Author
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Marlene Franke, S. Goenechea, Gerhard Rücker, and Use Schleiden-Schmid
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chemistry.chemical_classification ,Stereochemistry ,Metabolite ,Analgesic ,Pharmaceutical Science ,Glycoside ,Uronic acid ,Desmethyl ,chemistry.chemical_compound ,chemistry ,Drug Discovery ,medicine ,Tramadol ,Glucuronide ,medicine.drug - Published
- 2010
5. Peroxide Als Pflanzeninhaltsstoffe, 8. Mitt.: Guaianolid-Peroxide Aus Der Schafgarbe, Achillea Millefolium L., Auslöser Der Schafgarbendermatitis
- Author
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Gerhard Rücker, Judith Breuer, and D. Manns
- Subjects
chemistry.chemical_compound ,Achillea millefolium ,chemistry ,Stereochemistry ,Drug Discovery ,medicine ,Pharmaceutical Science ,medicine.disease ,Peroxide ,Allergic contact dermatitis - Abstract
Aus dem Ether-Extrakt der Blutenkopfchen der Schafgarbe (Achillea millefolium L.) wurden zwei Guaianolide (1,2) mit einer Peroxid-Brucke im Cyclopentan-Ring und einer α-Methylen-γ-butyrolacton-Struktur isoliert. Es werden die Bezeichnungen α-Peroxyachifolid (1) und β-Peroxyisoachifolid (2) vorgeschlagen. 1 ist u.a. verantwortlich fur die Schafgarbendermatitis. Peroxides as Plant Constituents, VIII1) Guaianolide-peroxides from Yarrow, Achillea millefolium L., Causing Allergic Contact Dermatitis From the ether extract of the blossoms of yarrow, Achillea millefolium L., two guaianolides (1, 2) with a peroxide bridged cyclopentane ring and an α-methylene-γ-butyrolactone structure have been isolated. For these compounds the names α-peroxyachifolid (1) and β-peroxyisoachifolid (2) are proposed. 1 is responsible for the allergic contact dermatitis caused by yarrow.
- Published
- 2010
6. Triterpenes with a new 9-epi-cucurbitan skeleton from Senecio selloi
- Author
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Rudolf Hartmann, D. Manns, Eloir Paulo Schenkel, Gerhard Rücker, and Berta M Heinzmann
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chemistry.chemical_classification ,biology ,Stereochemistry ,Chemistry ,Plant Science ,General Medicine ,Horticulture ,Asteraceae ,biology.organism_classification ,Biochemistry ,Terpene ,Triterpene ,Senecio selloi ,Molecular Biology - Abstract
From the fresh aerial parts of Senecio selloi (Asteraceae), two diastereomeric triterpenes with a hitherto unknown skeleton have been isolated. The structure has been elucidated mainly by advanced NMR experiments, including inverse techniques, HMQC, HMBC, ROESY.
- Published
- 1999
7. Alkaloids fromThalictrum przewalskii
- Author
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Eberhard Breitmaier, Ralf Mayer, G. L. Zhang, Gerhard Rücker, and Christoph Steinbeck
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Pharmacology ,Pavine ,biology ,Alkaloid ,Organic Chemistry ,Pharmaceutical Science ,Ranunculaceae ,Pharmacognosy ,biology.organism_classification ,Chloride ,Analytical Chemistry ,Thalictrum przewalskii ,chemistry.chemical_compound ,Complementary and alternative medicine ,chemistry ,Drug Discovery ,medicine ,Molecular Medicine ,Organic chemistry ,Benzylisoquinoline ,Magnoflorine ,medicine.drug - Abstract
Nine new alkaloids przewaline, przewalskine, przewalskinine, przewalstine, przewalstinine, przewalstidine, przewalstidinine, przewalidine chloride, and 8-hydroxypseudocoptisine chloride were isolated from Thalictrum przewalskii Maxim., together with the known alkaloids berberinium chloride, magnoflorine chloride, N-methylpalaudinium chloride, thalphenine chloride, and N-methylnantenium chloride. Their structures were determined by spectroscopy including EI-MS, FAB-MS, (1)H-NMR, (13)C-NMR, C,H-COSY, C,H-COLOC, HMQC and HMBC techniques.
- Published
- 1998
8. Allergenic sesquiterpene lactones fromEupatorium cannabinum L. andKaunia rufescens (Lund ex de Candolle)?
- Author
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Ralf Mayer, B. M. Hausen, Gerhard Rücker, D. Manns, Klemens Heiden, and Eloir Paulo Schenkel
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chemistry.chemical_compound ,Eupaformosanin ,biology ,Chemistry ,Botany ,Eupatoriopicrin ,Dehydroleucodin ,Eupatorium cannabinum ,Eupatorium ,Toxicology ,biology.organism_classification ,Sesquiterpene ,Kaunia rufescens - Abstract
From Eupatorium cannabinum L., a hitherto unknown α-methylene-γ-butyrolactone, 3β-peroxyeucannabinolide, was isolated. This compound and eupatoriopicrin from the same plant showed a weak sensitizing capacity in guinea pigs. 2-oxoludartin and dehydroleucodin, isolated from Kaunia rufescens (syn. Eupatorium rufescens), were strong sensitizers in the same sensitizarian procedure. Nat. Toxins 5:223–227, 1997. © 1998 Wiley-Liss, Inc.
- Published
- 1997
9. Peroxides and other constituents from Heterothalamus alienus
- Author
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Gerhard Rücker, Anne Marek, Eloir Paulo Schenkel, Miriam Falkenberg, and Detlef Manns
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Organic peroxide ,biology ,Stereochemistry ,Plant Science ,General Medicine ,Horticulture ,Asteraceae ,biology.organism_classification ,Biochemistry ,chemistry.chemical_compound ,Heterothalamus alienus ,chemistry ,Organic chemistry ,Molecular Biology - Abstract
Three new compounds, docosanoic cinnamate, 7-hydroperoxy-5,6-E-dehydro-6,7-dihydronerol and 2-(3-methylbut-3-enyl)-3-methyl-2,5-dihydrofuran were isolated from the leaves of Heterothalamus alienus and their structures determined by spectroscopical methods.
- Published
- 1996
10. Alkaloids from Hypecoum leptocarpum
- Author
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Gerhard Rücker, G. L. Zhang, Ralf Mayer, and Eberhard Breitmaier
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Traditional medicine ,biology ,Alkaloid ,Plant Science ,General Medicine ,Allocryptopine ,Horticulture ,biology.organism_classification ,Biochemistry ,chemistry.chemical_compound ,chemistry ,Hypecoum leptocarpum ,Papaveraceae ,Protopine ,Dihydrosanguinarine ,Molecular Biology - Abstract
Two new alkaloids, named isohyperectine and leptocarpine, were isolated from the whole plants of Hypecoum leptocarpum, along with the eight known alkaloids, dihydrosanguinarine, 8-acetonyldihydrosanguinarine, 8-methoxydihydrosanguinarine, oxohydrastinine, allocryptopine, protopine, hyperectine and corydamine. All structures were determined by spectroscopic methods.
- Published
- 1995
11. Alkaloids from Dactylicapnos torulosa
- Author
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Ralf Mayer, Eberhard Breitmaier, G. L. Zhang, Martin Nieger, Gerhard Rücker, and Christoph Steinbeck
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Stereochemistry ,Chemistry ,Chemical structure ,Alkaloid ,Plant Science ,General Medicine ,Horticulture ,Pharmacognosy ,Biochemistry ,Nmr data ,Hydrastinine chloride ,Phytochemical ,Dactylicapnos torulosa ,X ray analysis ,Molecular Biology - Abstract
Phytochemical investigation of Dactylicapnos torulosa yielded two known compounds, ( − )- cis - N -methylstylopiumchloride and hydrastinine chloride; and five new alkaloids, dactyline, 8-hydroxydihydrosanguinarine and dactylidine, as well as dactylicapnosine and dactylicapnosinine with novel CNOC moieties. All structures were elucidated by spectroscopical methods. The structure of dactylicapnosine was also determined by single crystal X-ray diffraction analysis.
- Published
- 1995
12. Malariawirksame Verbindungen aus Pflanzen, insbesondere Peroxide [1]
- Author
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Gerhard Rücker
- Subjects
Pharmacology ,Chemistry ,Pharmaceutical Science ,Pharmacology (medical) - Published
- 1995
13. Peroxides as Constituents of Plants, Part 19: A C50-Hydroperoxide fromHypericum perforatum
- Author
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D. Manns, Rudolf Hartmann, Gerhard Rücker, and Ulrike Bonsels
- Subjects
biology ,Chemistry ,Stereochemistry ,Hyperforine ,Pharmaceutical Science ,Hypericum perforatum ,Hypericaceae ,Pharmacognosy ,biology.organism_classification ,Terpenoid ,Hyperforin ,chemistry.chemical_compound ,Drug Discovery ,Two-dimensional nuclear magnetic resonance spectroscopy - Abstract
A new C 50 -hydroperoxide (1) with a hitherto unknown constitution, containing cadinane hydroperoxide and hyperforin (2) as partial structures, was isolated from the stems and leaves of St. John's wort (Hypericum perforatum L., Hypericaceae). The structure was elucidated by high-resolution NMR techniques (1D and 2D NMR experiments).
- Published
- 1995
14. Trennung des Fencamfamins in die Diastereomeren und Synthese einiger seiner Metaboliten
- Author
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Gerhard Vollberg, Gerhard Rücker, and Michael Neugebauer
- Subjects
Chromatographic separation ,chemistry.chemical_compound ,Chemistry ,Stereochemistry ,Metabolite ,Drug Discovery ,Diastereomer ,Pharmaceutical Science ,Chemical synthesis - Abstract
Es wird erstmalig die sc Trennung der Diastereomeren [la, lb] des Fencamfamins INN (1) und die Synthese einiger seiner potentiellen Metaboliten [2a, 2b, 3, 7a, 7b, 8] beschrieben. Separation of Fencamfamine into Diastereomers and Synthesis of Some of its Metabolites The column chromatographic separation of fencamfamine INN (1) into diastereomers 1a, 1b is reported. The synthesis of some of its possible metabolites [2a, 2b, 3, 7a, 7b, 8] is described.
- Published
- 1994
15. Peroxide als Pflanzeninhaltsstoffe, 15. Mitt.: Irreguläre Monoterpenperoxide ausAchillea filipendulina LAM
- Author
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Gerhard Rücker, Nikolaus Korber, Judith Breuer, and D. Manns
- Subjects
Terpene ,chemistry.chemical_compound ,biology ,Stereochemistry ,Chemistry ,Monoterpene ,Drug Discovery ,Santolina ,Pharmaceutical Science ,Asteraceae ,Ascaridole ,biology.organism_classification ,Achillea filipendulina - Abstract
Aus Achillea filipendulina LAM. (Asteraceae) wurden zwei bisher nicht bekannte diastereomere, irregulare acyclische Monoterpenperoxide 5, 6 vom Typ des Santolinatriens isoliert (4α- bzw. 4β-Peroxyachipendol). Die Konstitution von 5 wurde durch Rontgenstrukturanalyse gesichert. 5 und 6 bilden durch Reduktion die in der Lit. beschriebenen Alkohole 8, 9, deren Struktur aufgrund dieser Ergebnisse korrigiert werden mus. Zusatzlich wurden in A. filipendulina Ascaridol (1), trans-Pinocarveylhydroperoxid (2) und Isolyratylhydroperoxid A (3) und B (4) nachgewiesen. Peroxides as Constituents of Plants, XV: Irregular Monoterpene Peroxides from Achillea filipendulina LAM. From Achillea filipendulina LAM. (Asteraceae) two hitherto unknown diastereomeric, irregular acyclic monoterpene peroxides 5, 6 of santolina triene type have been isolated (4α- and 4β-peroxyachipendole). The constitution of 5 was confirmed by X-ray analysis. Reduction of 5 and 6 results in the formation of the alcohols 8 and 9, respectively. Constitutions of 8 and 9, reported in lit., have to be corrected. In addition, ascaridole (1), trans-pinocarveylhydroperoxide (2) and isolyratylhydroperoxide A (3) and B (4) have been found.
- Published
- 1994
16. Bisepoxylignan glycosides from Stauntonia hexaphylla
- Author
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Michael Neugebauer, Gerhard Rücker, Ralf Mayer, and Wang Huai-Bin
- Subjects
chemistry.chemical_classification ,Lignan ,biology ,Stereochemistry ,Chemistry ,Chemical structure ,Glycoside ,Stauntonia hexaphylla ,Plant Science ,General Medicine ,Horticulture ,biology.organism_classification ,Biochemistry ,Lardizabalaceae ,chemistry.chemical_compound ,Glucoside ,Proton NMR ,Spectral analysis ,Molecular Biology - Abstract
Three bisepoxylignan glycosides were isolated from Stauntonia hexaphylla . One is a new compound, (+)-1-hydroxysyringaresinol-1-β- d -glucoside named staunoside C, whilst the other two, (+)-fraxiresinol-1-β- d -glucoside and (+)-1-hydroxypinoresinol-1-β- d -glucoside, are reported in this genus for the first time. Structures were established on the basis of spectroscopic analysis and chemical evidence, and their 1 H NMR signals were assigned in detail by means of 2D-NMR techniques.
- Published
- 1993
17. Triterpenoid glycosides from Stauntonia hexaphylla
- Author
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Ralf Mayer, Gerhard Rücker, and Huai-Bin Wang
- Subjects
Magnetic Resonance Spectroscopy ,Stereochemistry ,Chemical structure ,Molecular Sequence Data ,Saponin ,Plant Science ,Spectrometry, Mass, Fast Atom Bombardment ,Horticulture ,Lardizabalaceae ,Biochemistry ,Terpene ,Triterpene ,Glycosides ,Oleanolic Acid ,Molecular Biology ,chemistry.chemical_classification ,biology ,Chemistry ,Glycoside ,Nuclear magnetic resonance spectroscopy ,General Medicine ,Fast atom bombardment ,Saponins ,biology.organism_classification ,Triterpenes ,carbohydrates (lipids) ,Carbohydrate Sequence ,Drugs, Chinese Herbal - Abstract
On the basis of spectroscopic and chemical methods, the structures of two new bisdesmosidic triterpenoid glycosides, named staunoside D and E, which were isolated from Stauntonia hexaphylla, were established as 3-O-(beta-D-glucopyranosyl(1-->2)-[beta-D- glucopyranosyl(1-->3)]-beta-D-glucopyranosyl)-hederagenin-28- O-[beta-D-glucopyranosyl (1-->6)-beta-D-glucopyranosyl] ester and 28-O-[alpha-L-rhamnopyranosyl (1-->4)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranosyl]ester, respectively. Three known triterpenoid glycosides were also isolated. A new proglycoside was isolated from the cleavage of the ester-glycosidic linkage and its structure characterized.
- Published
- 1993
18. Peroxide als Pflanzeninhaltsstoffe, 14. Mitt.: Über weitere Guaianolid-Peroxide aus der Schafgarbe,Achillea millefolium L
- Author
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Judith Breuer, Gerhard Rücker, and D. Manns
- Subjects
chemistry.chemical_classification ,chemistry.chemical_compound ,Achillea millefolium ,chemistry ,Stereochemistry ,Drug Discovery ,Pharmaceutical Science ,Nuclear magnetic resonance spectroscopy ,Sesquiterpene ,Lactone - Published
- 1993
19. Peroxide als Pflanzeninhaltsstoffe, 12. Mitt.: Peroxide vom Davanon-Typ aus der Eberraute (Artemisia abrotanum) und ihre Darstellung
- Author
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Detlef Manns, Sibylle Wilbert, and Gerhard Rücker
- Subjects
chemistry.chemical_compound ,Organic peroxide ,biology ,Chemistry ,Stereochemistry ,Drug Discovery ,Pharmaceutical Science ,Artemisia ,Asteraceae ,biology.organism_classification ,Peroxide - Abstract
Aus den oberirdischen Teilen der Eberraute (Artemisia abrotanum L., Asteraceae) wurden neben (+)-Davanon (1) und Arteinculton (3) die bekannten Peroxyhalbketale 2, 5 und 7 isoliert. Als neue Peroxide vom Davanon-Typ konnten Epi-Arteinculton (4) und Spiro-Arteinculton (6) durch dc Vergleich in der Pflanze nachgewiesen werden. Bei der Singulett-Sauerstoff-Oxidation von 1 werden 2, 3, 4, 5und 7 gebildet, bei der Triplett-Sauerstoff-Oxidation 2, 3, 5, 6, 7 und Hydroxy-Davanon. Peroxides as Plant Constituents, XII: Davanone Type Peroxides from Artemisia abrotanum and Their Preparation From the aerial parts of Artemisia abrotanum L. (Asteraceae), besides (+)-Davanone (1) and Arteincultone (2), the known peroxy-semiketals 2, 5, and 7 were isolated. In addition, the previously unknown davanone type peroxides epi-arteincultone (4) and spiro-arteincultone (6) were identified in A. abrotanum by TLC. By means of singlet oxygen oxidation of 1, compounds 2, 3, 4, 5, and 7 are formed, by triplet oxygen oxydation compounds 2, 3, 5, 6, 7 as well as hydroxy-davanone.
- Published
- 1993
20. Molluskizid wirksame Spiro-α-methylen-γ-butyrolactone
- Author
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Gerhard Rücker, K. Hostettmann, P. Böken, Werner Gajewski, and M. Löbbert
- Subjects
chemistry.chemical_classification ,chemistry ,biology ,Molluscicide ,Stereochemistry ,Drug Discovery ,Pharmaceutical Science ,Biomphalaria glabrata ,Biological activity ,Ethyl ester ,Reformatsky reaction ,biology.organism_classification ,Lactone - Abstract
Die α-Methylen-γ-butyrolactone 1-28 wurden auf molluskizide Wirkung gegen Biomphalaria glabrata untersucht. Die racem. Verbindung 25 ist am wirksamsten. Die Synthese erfolgte durch modifizierte Reformatzky-Reaktion aus den entspr. Carbonylverbindungen und Brommethylacrylsaureethylester. 7-10, 17 und 22-27 wurden erstmalig synthetisiert. α-Methylene-γ-butyrolactones with Molluscicidal Activity The α-methylene-γ-butyrolactones 1-28 were tested in vitro for molluscicidal activity against Biomphalaria glabrata. The racemic compound 25 shows the best activity. The synthesis was carried out by modified Reformatzky reaction of the corresponding carbonyl compounds and bromomethylacrylic acid ethyl ester. 7-10, 17 and 22-27 have been synthesized for the first time.
- Published
- 1993
21. Synthesis of the β-D-Glucuronides of 2,3-, 3,4-, and 2,6-Dichlorophenol
- Author
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S. Goenechea, Marcus A. Hubert, and Gerhard Rücker
- Subjects
2,6-Dichlorophenol ,chemistry.chemical_compound ,Chemistry ,Drug Discovery ,Pharmaceutical Science ,Organic chemistry ,Uronic acid ,Alkaline hydrolysis (body disposal) ,Cleavage (embryo) ,Glucuronide ,Chemical synthesis - Abstract
The beta-D-glucuronides of 2,3-, 3,4-, and 2,6-dichlorophenol (1-3) were prepared by a modified Koenigs-Knorr synthesis. As the alkaline hydrolysis of perpivaloylated methyl (2,3-dichlorophenyl)-glucuronate 1a led to a dehydrated glucuronide, the preparation of peracetylated methyl dichlorophenylglucuronates with subsequent cleavage of the ester bindings under mild conditions was preferred.
- Published
- 2001
22. Acetylenic Glucosides fromMicroglossa pyrifolia1,*
- Author
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F. Goeltenboth, H. Sakulas, S. Kehrbaum, Gerhard Rücker, and B. Lawong
- Subjects
Pharmacology ,chemistry.chemical_classification ,Folk medicine ,biology ,Stereochemistry ,Organic Chemistry ,Pharmaceutical Science ,Glycoside ,New guinea ,Asteraceae ,biology.organism_classification ,Analytical Chemistry ,chemistry.chemical_compound ,Complementary and alternative medicine ,Glucoside ,chemistry ,Drug Discovery ,Molecular Medicine ,Microglossa pyrifolia ,Antibacterial activity - Abstract
From the leaves of Microglossa pyrifolia Lam. (Asteraceae) four new acetylenic glucosides (1-4) have been isolated. The aglucones 2a and 4a are new polyynes. The aglucone 3a could only be isolated as a mixture of E/Z-isomers in a ratio of 4:1. The structures of 1-4 were elucidated by spectroscopic and biochemical methods. Compound 1 shows antibacterial activity.
- Published
- 1992
23. Cucurbitacins from Wilbrandia ebracteata
- Author
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Eloir Paulo Schenkel, Mareni Rocha Farias, Gerhard Rücker, Ralf Mayer, and Eberhard Breitmaier
- Subjects
Cucurbitacins ,Botany ,Plant Science ,General Medicine ,Horticulture ,Wilbrandia ebracteata ,Biology ,Molecular Biology ,Biochemistry - Abstract
Three new cucurbitacins were isolated from the roots of Wilbrandia ebracteata and their structures established as 16α, 23α-epoxy-2β,3β,20β-trihydroxy-10α,23β-cucurbit-5,24-dien-11-one, 16α,23α-epoxy-2β,3β,20β-trihydroxy- 10α,23α-cucurbit-5,24-dien-11-one and 2β,3β,16α,20,25-pentahydroxy-10α-cucurbit-5,23-dien-11-one, mainly by spectroscopy.
- Published
- 1992
24. Synthese einiger Metaboliten und der Enantiomeren des Prolintans
- Author
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Gerhard Rücker, Dafang Zhong, and Michael Neugebauer
- Subjects
chemistry.chemical_compound ,chemistry ,Stereochemistry ,Drug Discovery ,medicine ,Pharmaceutical Science ,Alcohol ,Prolintane ,Enantiomer ,Aliphatic compound ,medicine.drug - Abstract
Zur Untersuchung des Metabolismus des Kreislauftonikums Prolintan (1) (Katovit®) wurden 15 potentielle Metaboliten synthetisiert. Auserdem wird uber die Synthese der Enantiomeren von 1, ausgehend von R-(+)- bzw. S-(-)-Phenylalaninol berichtet. Synthesis of Possible Metabolites and the Enantiomers of Prolintane. The synthesis of 15 possible metabolites of prolintane (1) (Katovit®) which is used in the treatment of blood pressure disregulations is described. Furthermore, the preparation of the enantiomers of 1 is reported, starting with R-(+)- and S-(-)-phenylalaninol respectively.
- Published
- 1992
25. Medicinal Plants from Papua New Guinea: Graniline-Esters and Germacranolides fromBlumea arfakiana
- Author
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F. Goeltenboth, G. Paulini, Gerhard Rücker, B. Lawong, and H. Sakulas
- Subjects
Pharmacology ,Stigmasterol ,biology ,Organic Chemistry ,Pharmaceutical Science ,New guinea ,Blumea arfakiana ,Asteraceae ,biology.organism_classification ,Analytical Chemistry ,chemistry.chemical_compound ,Complementary and alternative medicine ,chemistry ,Drug Discovery ,Botany ,Molecular Medicine ,Medicinal plants - Abstract
From the leaves of BLUMEA ARFAKIANA Martelli (Asteraceae), used in traditional medicine in Papua New Guinea, besides stigmasterol and beta-eudesmol, four graniline esters ( 1-4) have been isolated. Furthermore, blumealactone C ( 5), deacetylblumealactone C ( 6), and deoxyblumealactone C ( 7) have been identified.
- Published
- 1991
26. Mass spectrometric identification of unsaturated terpene hydrocarbons by GC–MS after derivatization with trioxo(tert-butylimido)osmium(VIII)
- Author
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B. Daldrup, Michael Neugebauer, and Gerhard Rücker
- Subjects
chemistry.chemical_classification ,Degree of unsaturation ,Double bond ,chemistry.chemical_element ,General Chemistry ,Mass spectrometry ,Chemical reaction ,Hydrocarbon ,chemistry ,Mass spectrum ,Organic chemistry ,Osmium ,Isomerization ,Food Science - Abstract
The mass spectrometric identification of unsaturated mono- and sesquiterpene hydrocarbons during the GC–MS analysis of essential oils is often difficult owing to lack of characteristic fragmentation patterns and because of isomerization and molecular rearrangements. Reaction of mono- and sesquiterpenes containing one or two non-conjugated double bonds with trioxo(tert-butylimido)osmium(VIII) gives vicinal monoamino alcohols, bisamino alcohols and aminotriols after reduction of the intermediate osmate ester amides. These derivatives show characteristic mass spectra which can be used as a ‘fingerprint’ for the identification of the respective parent compound. Moreover, it seems possible to derive some key fragments from the mass spectra, which can indicate the presence of certain types of alkenoic unsaturation in the hydrocarbon. This is true for vicinal disubstituted exocyclic double bonds, isopropenyl double bonds and methylsubstituted endocyclic double bonds.
- Published
- 1990
27. Peroxide als Pflanzeninhaltsstoffe, 7. Mitt.1): Bildung des Sesquiterpenperoxids Nardosinon aus einer Aristolan-Vorstufe
- Author
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Gerhard Rücker, Luo Shide, and Armin Olbrich
- Subjects
chemistry.chemical_classification ,Valerianaceae ,Ketone ,biology ,Autoxidation ,Stereochemistry ,Pharmaceutical Science ,Ether ,biology.organism_classification ,Sesquiterpene ,chemistry.chemical_compound ,chemistry ,Drug Discovery ,Nardosinone ,Phenols ,Enone - Abstract
Der 1,2-Dioxolanring des Sesquiterpenperoxids Nardosinon (1) aus Nardostachys chinensis Batalin (Valerianaceae) wird durch Flussigphasen-Autoxidation aus dem Cyclopropan-Ring des Aristolan-Ketons Gansongon (3) gebildet, welches in der gleichen Pflanze vorkommt. 3 wurde auch aus (−)-9-Aristolen (6) synthetisiert. Als Nebenprodukte der Bildung von 1 wurden die Hydroperoxide 11 und 12 sowie Kanshon C (15) isoliert. Mit p-Benzochinon entsteht aus 3 der Ether 16. Zusatz verschiedener Phenole fuhrt zu einer Erhohung der Ausbeute an 1 bis zu 50%. Der mogliche Reaktionsablauf wird diskutiert. Peroxides as Plant Constituents, VII: Formation of the Sesquiterpeneperoxide Nardesinone from an Aristolane Precursor++) The 1,2-dioxolanering of the sesquiterpeneperoxide nardosinone (1) from Nardostachys chinensis Batalin (Valerianaceae) is formed by liquid-phaseautoxidation of the cyclopropane from the aristolane ketone, gansongone (3), which exists in the same plant. 3 was also obtained synthetically from (−)-9-aristolene (6). Beside 1 the two hydroperoxides 11 and 12 and in addition kanshone C (15) were isolated. Using p-benzoquinone, 3 was converted to the ether 16. In the presence of different phenols, the yield of 1 was increased up to 50%. The possible pathway of the reaction is discussed.
- Published
- 1990
28. Pindrolactone, a lanostane derivative from the leaves of Abies pindrow
- Author
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Vidya B. Pandey, Manju Tripathi, Gerhard Rücker, Luna Jain, and Anil B. Ray
- Subjects
chemistry.chemical_classification ,biology ,Abies pindrow ,Traditional medicine ,Chemistry ,Stereochemistry ,Plant Science ,General Medicine ,Horticulture ,biology.organism_classification ,Biochemistry ,Lanostane ,chemistry.chemical_compound ,Triterpenoid ,Triterpene ,Pinaceae ,Molecular Biology ,Derivative (chemistry) - Abstract
Pindrolactone, a new tetracyclic triterpenoid, has been isolated from the leaves of Abies pindrow and its structure advanced as 3α-hydroxylanosta-7,9(11),22E,24-tetraen-26,23-olide.
- Published
- 1996
29. Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells
- Author
-
Mary W. Davey, Thomas Efferth, Ross A. Davey, Gerhard Rücker, Erich Gebhart, and Armin Olbrich
- Subjects
Daunorubicin ,Immunology ,Pharmacology ,chemistry.chemical_compound ,hemic and lymphatic diseases ,Tumor Cells, Cultured ,Medicine ,Humans ,MTT assay ,Drug Interactions ,ATP Binding Cassette Transporter, Subfamily B, Member 1 ,Artemisinin ,Medicine, Chinese Traditional ,Molecular Biology ,Dose-Response Relationship, Drug ,business.industry ,Bufalin ,Cell Biology ,Hematology ,Drug Resistance, Multiple ,Baicalein ,Cell killing ,chemistry ,Artesunate ,Drug Resistance, Neoplasm ,Homoharringtonine ,Molecular Medicine ,Multidrug Resistance-Associated Proteins ,Drug Screening Assays, Antitumor ,business ,Cell Division ,medicine.drug ,Drugs, Chinese Herbal - Abstract
There is considerable interest among basic and clinical researchers in novel drugs with activity against leukemia. The vast history of experience of traditional Chinese medicine (TCM) with medicinal plants may facilitate the identification of novel antileukemic compounds. In the present investigation, we tested 22 drugs for their activity toward CCRF-CEM cell lines: artesunate, artemisinin, baicalein, baicalin, berberine, bufalin, cantharidin, cephalotaxine, curcumin, daidzein, daidzin, diallyl disulfide, ginsenoside Rh2, glycyrrhizic acid, isonardosinon, homoharringtonine, nardosinon, nardofuran, puerarin, quercetin, tannic acid, and tetrahydronardosinon. As compounds from folk medicinal remedies are sometimes looked upon as alternative medicine with some hesitation or criticism, we investigated only chemically pure compounds and tested the drugs independently in two different laboratories in Germany and Australia. We used CCRF-CEM parental cells and doxorubicin-selected P-glycoprotein (P-gp)/MDR1-expressing CEM/ADR5000, vinblastine-selected P-gp/MDR1-expressing CEM/VLB(100), and epirubicin-selected multidrug resistance-related protein 1 (MRP1)-expressing CEM/E1000 sublines thereof. While CEM/ADR5000, CEM/VLB(100), and CEM/E1000 cells were highly resistant to the corresponding selecting agents, no or only minimal degrees of cross-resistance were observed to TCM drugs in both growth inhibition assay and MTT assay (range from 0.4- to 8-fold). Homoharringtonine, artesunate, and bufalin were most active among this panel of compounds. As shown by flow cytometry, artesunate significantly increased daunorubicin accumulation in CEM/E1000 cells, but not in CEM/VLB(100) or CCRF-CEM parental cells. Bufalin caused a small, but significant increase in daunorubicin accumulation in CEM/VLB(100) and CEM/E1000 cells. As artesunate and bufalin showed both antileukemic activity if applied alone and modulation activity in combination with daunorubicin in multidrug-resistant (MDR) cells, these two drugs may be suitable for novel combination treatment regimens to improve leukemia cell killing.
- Published
- 2002
30. Revised structure and stereochemistry of jatamansic acid
- Author
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Ralf Mayer, Leonore Wiehl, Eberhard Breitmaier, Georg Will, Gerhard Rücker, and Shashikumar K. Paknikar
- Subjects
chemistry.chemical_classification ,Valerianaceae ,biology ,Bicyclic molecule ,Chemistry ,Stereochemistry ,Carboxylic acid ,Nardostachys jatamansi ,Plant Science ,General Medicine ,Horticulture ,biology.organism_classification ,Biochemistry ,Molecule ,Organic chemistry ,Molecular Biology - Abstract
The structure ofjatamansic acid has been revised from 2D-NMR data, an INADEQUATE experiment and X-ray diffraction analysis. The stereochemistry was con
- Published
- 1993
31. Isoachifolidien, eine Vorstufe von Guaianolid-Peroxiden ausAchillea millefolium1
- Author
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A. Kiefer, Gerhard Rücker, and J. Breuer
- Subjects
Pharmacology ,Achillea millefolium ,Complementary and alternative medicine ,Achillea ,Chemical structure ,Organic Chemistry ,Drug Discovery ,Botany ,Pharmaceutical Science ,Molecular Medicine ,Biology ,biology.organism_classification ,Analytical Chemistry - Published
- 1992
32. Triterpensaponine aus der chinesischen Droge 'Daxueteng' (Caulis Sargentodoxae)
- Author
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J.-S. Shin-Kim, R. Mayer, and Gerhard Rücker
- Subjects
Pharmacology ,chemistry.chemical_classification ,Folk medicine ,Traditional medicine ,Chinese drug ,Organic Chemistry ,Saponin ,Pharmaceutical Science ,Catechin ,Pharmacognosy ,Biology ,Analytical Chemistry ,chemistry.chemical_compound ,Sargentodoxa cuneata ,Complementary and alternative medicine ,chemistry ,Triterpene ,Drug Discovery ,Botany ,Molecular Medicine ,Rosamultin - Abstract
From the chinese drug "Daxueteng" (Caulis Sargentodoxae: Sargentodoxa cuneata (Oliv.) Rehd. et Wils.; syn. Holboellia cuneata Oliv.) (Sargentodoxaceae), catechin and two known triterpene saponins, rosamultin (7) and kajiichigoside F1 (8) have been isolated. Some hitherto unknown reaction products of the saponins are described. Both 7 and 8 show haemolytic and in vitro antiviral activity.
- Published
- 1991
33. L
- Author
-
Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow, and A. Kluge
- Published
- 1999
34. Q
- Author
-
Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow, and A. Kluge
- Published
- 1999
35. M
- Author
-
Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow, and A. Kluge
- Published
- 1999
36. P
- Author
-
Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow, and A. Kluge
- Published
- 1999
37. O
- Author
-
Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow, and A. Kluge
- Published
- 1999
38. R
- Author
-
Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow, and A. Kluge
- Published
- 1999
39. U
- Author
-
Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow, and A. Kluge
- Published
- 1999
40. N
- Author
-
Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow, and A. Kluge
- Published
- 1999
41. Z
- Author
-
Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow, and A. Kluge
- Published
- 1999
42. T
- Author
-
Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow, and A. Kluge
- Published
- 1999
43. S
- Author
-
Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow, and A. Kluge
- Published
- 1999
44. X
- Author
-
Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow, and A. Kluge
- Published
- 1999
45. V
- Author
-
Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow, and A. Kluge
- Published
- 1999
46. Y
- Author
-
Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow, and A. Kluge
- Published
- 1999
47. Manshurolide, a sesquiterpene lactone from Aristolochia manshuriensis
- Author
-
Ralf Mayer, Chen Wei Ming, Andrea Güllmann, Georg Will, and Gerhard Rücker
- Subjects
chemistry.chemical_classification ,Stereochemistry ,Carbon skeleton ,Aristolochia manshuriensis ,Plant Science ,General Medicine ,Horticulture ,Biology ,biology.organism_classification ,Sesquiterpene lactone ,Sesquiterpene ,Biochemistry ,Terpenoid ,chemistry.chemical_compound ,chemistry ,Aristolochiaceae ,Organic chemistry ,Molecular Biology ,Lactone - Abstract
A sesquiterpene lactone manshurolide with an hitherto unknown carbon skeleton was isolated from Aristolochia manshuriensis. Its structure was elucidated by spectroscopic means and X-ray analysis.
- Published
- 1990
48. Antimalarial activity of 1,4-epidioxy-bisabola-2,12-diene derivatives
- Author
-
Eberhard Breitmaier, Berta M Heinzmann, Klemens Heiden, Gerhard Rücker, D. Manns, Stephan Seggewies, Walter A. Maier, and Anne Marek
- Subjects
Organic peroxide ,Curcumin ,Magnetic Resonance Spectroscopy ,Bicyclic molecule ,biology ,Diene ,Photochemistry ,Pharmaceutical Science ,Plasmodium falciparum ,Mice, Inbred Strains ,Sesquiterpene ,biology.organism_classification ,Chemical synthesis ,In vitro ,chemistry.chemical_compound ,Antimalarials ,Mice ,chemistry ,In vivo ,Drug Discovery ,Organic chemistry ,Animals ,Female ,Sesquiterpenes - Abstract
1,4-Epidioxy-bisabola-2,12-diene (3) and aromatic hydroperoxides (4, 5) were prepared by photoxidation of gamma-curcumene (1). Reduction and esterification of 6 and 7 afforded compounds 9 to 10. All compounds were tested in vitro for antimalarial activity. The activity could not be increased significantly, compared with 3. The most active compounds, 3 and 9, did not show in vivo antimalarial activity in mice.
- Published
- 1997
49. Acetylated Aurone Glucosides from Microglossa pyrifolia1
- Author
-
F. Goeltenboth, S. Kehrbaum, B. Lawong, Gerhard Rücker, and H. Sakulas
- Subjects
Pharmacology ,Folk medicine ,biology ,Traditional medicine ,Organic Chemistry ,Pharmaceutical Science ,Microglossa ,Pharmacognosy ,biology.organism_classification ,Analytical Chemistry ,chemistry.chemical_compound ,Complementary and alternative medicine ,chemistry ,Glucoside ,Acetylation ,Drug Discovery ,Aurone ,Botany ,Molecular Medicine ,Microglossa pyrifolia - Published
- 1994
50. T
- Author
-
Margitta Albinus, Gudrun Amschler, Uwe Amschler, Erwin von Angerer, Wolfgang Barthel, Andrea Bauer, Kurt Bauer, Jürgen Beckmann, Winfried Beil, Jürgen Beitz, Petra Berscht, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bracher, Helmut Bräunlich, Kerstin Brinkmann, Franz von Bruchhausen, Kay Brune, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Siegfried Ebel, Kurt Eger, Peter Emig, Thomas Erker, Maria S. Fernandez-Alfonso, August Wilhelm Frahm, Margarete Frahm, Klaus-Jürgen Freundt, Detlef Geffken, Ulrich Geis, Erika Glusa, Berthold Göber, Jochen Gödicke, Margarete Goppelt-Strübe, Wilhelm Gössling, Annette Graul, Sibylle Greiner, Adolf Grisk, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Axel Haberkorn, Eberhard Hackenthal, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Andreas Hensel, Sibylle Hoedt-Schmidt, Hermann Hoffmann, Ute Hoffmann-Schollmayer, Ulrike Holzgrabe, Martin Hug, Wolfgang Ibrom, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Nasser Khudeir, Werner Kiefer, Doris Kleinsorge, Christoph Klett, Stephanie Klett, Martin Klingmüller, H.-P. Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, Gottfried Kreutz, Reinhard Kroker, Dorothea Landsiedel-Maier, Jochen Lehmann, Marion Sylvia Lehner, Stefan Leiner, Hans Löwe, Johannes Mann, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Hans-Jürgen Mest, Frank Peter Meyer, J. Mollière, Rudolf Morgenstern, Wolfgang Morick, Joachim Mössner, Christa Müller, Daniel Müller, Klaus Müller, Walter Müller, Alexander Mülsch, Tilo Netzer, Michael Neugebauer, Ulf Niemeyer, Peter Nuhn, Bernd Nürnberg, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Martina Pickert, Andreas Pies, Klaus Pietrzik, Detlef Preiss, Helmut Priewer, Olaf Queckenberg, Eberhard Reimann, Jörg Remien, Rainer Rettig, Andreas Reymann, Joachim Richter, Hans Rommelspacher, Ulrich Rose, Gerhard Rücker, Klaus Schaefer, Helmut Schlager, Werner Schleicher, Hildegard Schleinitz, Wolfgang Schlichter, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Helmut Schwilden, Monika Serke, Gisela Skopp, Marcus Spohn, Ralf Stahlmann, Johannes-Peter Stasch, Christian Steffen, Jürgen Steinmeyer, Karl-Heinz Surborg, Ulf Sürig, Istvan Szelenyi, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Franz-Josef Volk, Heinz Walther, Horst Weber, Judith Wede, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Hilke Winterhoff, Reinhold Wintersteiger, Frauke Woltmann, Diaa Youssef, and A. Ziegler
- Published
- 1994
Catalog
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