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13 results on '"Gerhard Ditscherlein"'

1. Abstracts of the 15th Congress of the European Society for Urological Research, Istanbul, October 5–7, 2000

Author

E. Van Laecke, Hein Van Poppel, J. Caparros, Dirk-Henrik Zermann, Maria-Edite Rio, L. Costa, Robert J. Goodwin, Vincenzo Serretta, T. Mitsui, Shiv Srivastava, A. M. Petrinelli, Francesco La Rosa, Ahmed Said Zribi, Stefan A. Loening, Takatsugu Okegawa, V. Mastrandrea, J.L.H. Ruud Bosch, T. Koyanagi, R. Hohenfellner, Christopher R. Chapple, Horst Schlechte, Kikuo Nutahara, Dietmar Schnorr, Yassine Nouira, Christer Dahlstrand, Fabrizio Stracci, Ciro Pesce, Birgit Heidenreich, G. Ronquist, Vincenzo Ficarra, K. Minami, Antonio D'Amico, Fethi Attyaoui, Carlos Silva, Richard A. Schmidt, Manabu Ishigooka, Markus D. Sachs, Gerhard Ditscherlein, Lukas Lusuardi, L. Carlsson, L. Lennartsson, Luc Baert, Luciano Musi, J.M. Wolff, Gianni Malossini, C. Errando, Hans Goethuys, U.W. Tunn, Volker S. Lenk, Luc Vanuytsel, Paolo Beltrami, Barbara Fleige, Paola Casucci, Eiji Higashihara, Judd W. Moul, Isabell A. Sesterhenn, Morten Andersen, Clare J. Fowler, B.O. Nilsson, Sebastian Brenner, J.E. Batista, Gaetano Mobilio, Jörg Schubert, S. Nilsson, Imed Kbaier, Paolo Campobasso, Haruhisa Noda, Giorgio Pomara, C. Tallarigo, H. Goeminne, Wim Van de Voorde, P. Hoebeke, Kjetil Høye, Leoluca Zimbardo, Piet Callewaert, P. Arañó, Francisco Cruz, Tomáš Hanuš, Elisa Esposito, H. Morita, Andreas Sesterhenn, J. Vicente, Axel Heidenreich, P De Kuyper, Neil D. Kitchen, K. Everaert, Ali Horchani, Ignazio Rizzo, Michael J. Swinn, and T. Furuno

Subjects
Pediatrics, medicine.medical_specialty, business.industry, Urology, Family medicine, medicine, business
Published
2000
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2. p53 Tumour Suppressor Gene Mutations in Benign Prostatic Hyperplasia and Prostate Cancer

Author

Dietmar Schnorr, Horst Schlechte, Gerhard Ditscherlein, Thomas Löning, Birgit Rudolph, Stefan A. Loening, and Severin V. Lenk

Subjects
Male, Pathology, medicine.medical_specialty, Adenoma, Urology, medicine.medical_treatment, Prostatic Hyperplasia, Adenocarcinoma, urologic and male genital diseases, Polymerase Chain Reaction, Sensitivity and Specificity, Malignant transformation, Diagnosis, Differential, Prostate cancer, Gene Frequency, Reference Values, Prostate, Culture Techniques, medicine, Humans, Point Mutation, Frameshift Mutation, Aged, Aged, 80 and over, Prostatectomy, business.industry, Point mutation, Biopsy, Needle, Prostatic Neoplasms, DNA, Neoplasm, Sequence Analysis, DNA, Middle Aged, Hyperplasia, Genes, p53, medicine.disease, Immunohistochemistry, medicine.anatomical_structure, business, Temperature gradient gel electrophoresis
Abstract

To identify and analyse point mutations in p53 tumour suppressor gene (Tp53) in benign prostatic hyperplasia (BPH) by temperature gradient gel electrophoresis (TGGE) and sequence.141 tissue specimens (approx. 100 mg) after transurethral resection of the prostate (TURP), 12 specimens after needle biopsy. Control samples for genetic analysis were (a) 7 prostate tissues without any sign of BPH and malignancy and (b) 103 prostate cancer (PCa) tissues. DNA of the critical Tp53 exons 5-8 was amplified and run on horizontal polyacrylamide gels under defined temperature conditions (TGGE) to yield specific gel shifts and sets of homo- and heteroduplexes in case of mutation. Sequencing with a laser-fluorescent electrophoresis unit was done from re-amplified mutant and wild-type bands.TGGE screening of 153 BPH samples identified 29 specimens with Tp53 mutations (5 in exon 5, 11 in exon 6, 12 in exon 7, 3 in exon 8; 1 tissue sample showed mutations in 3 exons at a time). The computed mutation frequency was 19.0%. Two patients, with mutation in BPH tissue, developed PCa 2-3 years after TURP. One patient with mutation in BPH tissue developed bladder cancer. Of 118 patients with non-mutated DNA in BPH, none is known to have a urological cancer. The Tp53 mutation frequency in 103 PCa samples was 26.2%. Significant differences of mutation frequency between BPH and PCa were detected only in lower exon 5 mutation counts in BPH.Tp53 mutation in BPH tissue may be a tumour risk factor.

Published
1998
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3. Genetic analysis of Tp53 from urine sediment as a tool for diagnosing recurrence and residual of bladder carcinoma

Author

Volker S. Lenk, Horst Schlechte, Barbara Fleige, Dietmar Schnorr, Stefan A. Loening, Markus D. Sachs, Gerhard Ditscherlein, and Sebastian Brenner

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Urology, DNA Mutational Analysis, Urine, urologic and male genital diseases, Genetic analysis, medicine, Carcinoma, Urine sediment, Humans, neoplasms, Aged, Aged, 80 and over, Carcinoma, Transitional Cell, Bladder cancer, Urinary bladder, business.industry, Middle Aged, medicine.disease, Genes, p53, female genital diseases and pregnancy complications, Transitional cell carcinoma, medicine.anatomical_structure, Urinary Bladder Neoplasms, Mutation, Female, Neoplasm Recurrence, Local, Tumor Suppressor Protein p53, business, Complication
Abstract

Longitudinal study of Tp53 mutation in urine sediments of 26 patients with mutated primary transitional cell carcinoma (TCC) of the urinary bladder at different time periods after transurethral resection of the bladder (TURB), i.e. before and after the first TURB, prior to the control resection and before treatment of a recurrence.DNA of the critical Tp53 exons 5-8 was anaylzed by temperature gradients (TGGE) and sequence.(1) In 11 of 12 patients (91.7%) mutation reoccurred with the detection of recurrence of the disease. The mutation frequency in patients without any recurrence was 1 in 8 (12.5%) after a follow-up period of 4-16 months. (2) In 7 of 10 patients, the mutation was no longer detectable in the urine sediment after TURB. (3) The mutation frequency at the control resection 6 weeks after the first TURB was 5 in 7 (71.4%) in patients found to have residual and 1 in 7 (14.2%) in the tumor-free patients. (4) In 9 of 10 samples identical mutations were found by sequence in the recurrent tumor. These results show a significant correlation between the detection of a Tp53 mutation in the urine sediments and tumor recurrence or residual.(1) Tp53 mutations in the urine sediment could be a useful indicator of tumor recurrence or tumor residual in patients ( approximately 40%) with primary mutated bladder cancer tissue. (2) These results support the monoclonal seeding theory. (3) The finding of identical mutations at different times indicate that the tumor was never totally removed.

Published
2000

4. Curriculum in urology renal failure and andrology

Author

Chin-Hua Yang, Miguel A. Barranco, Yasuo Uchiyama, R. Solà, Atsushi Takahashi, Severin V. Lenk, L. Guirado, Dimitrios Siablis, Antonio Alcaraz, Ricardo Alvarez-Vijande, Kuang-Kuo Chen, Juan Llopis, Pierre Colombeau, Juan M. Corral, Kazunori Hattori, Recep Büyükalpelli, George Nikiforidis, Stefan A. Loening, Stéphane Richard, Jack H. Mydlo, John G. Kral, Patrice Pfeifer, George A. Barbalias, François Labrousse, Taiji Tsukamoto, Pablo Carretero, J. Caparrós, Gerhard Ditscherlein, Franck Salomé, Michael A. Volpe, Véronique Fermeaux, Thomas Löning, J. Martí, Hideyuki Akaza, C. Mallofré, Louis P. Pertschuk, Constantine Axotis, Saban Sarikaya, Toshihiro Hisataki, Richard J. Macchia, A. Collado, S. Yildiz, Dietmar Schnorr, Jean Jacques Moreau, Manel Solé, Masaaki Satoh, Maria J. Ribal, Ramazan Asci, Philippe Cazaux, Alfredo Rodríguez, Luke S. Chang, J. Vicente, Birgit Rudolph, Toru Shimazui, A. Rosales, Katsunori Uchida, Ali Faik Yilmaz, Naoya Masumori, Alex T.L. Lin, Noriomi Miyao, Horst Schlechte, E.N. Liatsikos, Jean Philipes Dumas, and Kenkichi Koiso

Subjects
Andrology, medicine.medical_specialty, business.industry, Urology, Medicine, business, Curriculum
Published
1998

5. Notice of Duplicate Publication

Author

Francesco La Rosa, Takatsugu Okegawa, Luciano Musi, Manabu Ishigooka, Volker S. Lenk, P De Kuyper, Vincenzo Ficarra, Kjetil Høye, Antonio D'Amico, G. Ronquist, Luc Vanuytsel, Paola Casucci, Gaetano Mobilio, Leoluca Zimbardo, Jörg Schubert, Paolo Beltrami, Piet Callewaert, P. Arañó, Luc Baert, C. Errando, Fabrizio Stracci, Christopher R. Chapple, Francisco Cruz, Andreas Sesterhenn, Imed Kbaier, Robert J. Goodwin, Ciro Pesce, Shiv Srivastava, Carlo Tallarigo, Vincenzo Serretta, Giorgio Pomara, Richard A. Schmidt, T. Koyanagi, Maria-Edite Rio, B.O. Nilsson, Dietmar Schnorr, Christer Dahlstrand, L. Carlsson, S. Nilsson, Hans Goethuys, U.W. Tunn, T. Mitsui, Gianni Malossini, A. M. Petrinelli, Eiji Higashihara, Judd W. Moul, Ahmed Said Zribi, E. Van Laecke, J.E. Batista, Stefan A. Loening, Fethi Attyaoui, L. Lennartsson, Hein Van Poppel, Dirk-Henrik Zermann, V. Mastrandrea, Michael J. Swinn, H. Goeminne, J.M. Wolff, Wim Van de Voorde, Barbara Fleige, P. Hoebeke, J. Caparros, J.L.H. Ruud Bosch, R. Hohenfellner, L. Costa, Kikuo Nutahara, Axel Heidenreich, Carlos Silva, Neil D. Kitchen, Birgit Heidenreich, Ignazio Rizzo, Horst Schlechte, Elisa Esposito, H. Morita, K. Everaert, Ali Horchani, J. Vicente, Tomáš Hanuš, Sebastian Brenner, Yassine Nouira, K. Minami, Markus D. Sachs, Gerhard Ditscherlein, T. Furuno, Isabell A. Sesterhenn, Clare J. Fowler, Paolo Campobasso, Haruhisa Noda, Lukas Lusuardi, and Morten Andersen

Subjects
Gynecology, medicine.medical_specialty, Notice, business.industry, Urology, Medicine, Library science, Duplicate publication, business
Published
2000
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7. Punktionsfolgen beim Menschen

Author

Gerhard Ditscherlein

Abstract

Trotz der grosen Zahl von Nierenbiopsiebeurteilungen durch unser Institut verfugen wir im Obduktionsgut nur uber wenige Falle mit vorangegangener Punktion. Daher werden bewust entsprechende Literaturangaben relativ ausfuhrlich zitiert. Wegen der grosen praktischen Bedeutung der klinischen Komplikationen konnen auch diese nicht ubergangen werden.

Published
1969
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12. Punktionsfolgen bei Säugetieren

Author

Gerhard Ditscherlein

Abstract

Die verschiedensten pathologisch-anatomischen Befunde an der Niere von Kaninchen sind in Tabelle 2 zusammengestellt. Wir unterscheiden dabei zwei grose Gruppen.

Published
1969
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13. An adolescent with acute renal failure, thrombocytopenia and femoral vein thrombosis

Author

Jochen H. H. Ehrich, Stefan A. Loening, Gerhard Ditscherlein, Birgit Rudolph, Guido Filler, Tobias Petras, and Miriam Zimmering

Subjects
Hemolytic anemia, medicine.medical_specialty, Adolescent, Femoral vein, Kidney, Immunopathology, medicine, Humans, Ureteral Diseases, Platelet, Inflammation, Transplantation, business.industry, Vascular disease, Thrombosis, Femoral Vein, medicine.disease, Antiphospholipid Syndrome, Surgery, Microscopy, Electron, Nephrology, Hemolytic-Uremic Syndrome, Female, business, Complication, Kidney disease

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