Search

Your search keyword '"Gereau, Robert W"' showing total 450 results
Start Over Author "Gereau, Robert W"
450 results on '"Gereau, Robert W"'

2. A photoswitchable GPCR-based opsin for presynaptic inhibition

Author

Copits, Bryan A, Gowrishankar, Raaj, O'Neill, Patrick R, Li, Jun-Nan, Girven, Kasey S, Yoo, Judy J, Meshik, Xenia, Parker, Kyle E, Spangler, Skylar M, Elerding, Abigail J, Brown, Bobbie J, Shirley, Sofia E, Ma, Kelly KL, Vasquez, Alexis M, Stander, M Christine, Kalyanaraman, Vani, Vogt, Sherri K, Samineni, Vijay K, Patriarchi, Tommaso, Tian, Lin, Gautam, N, Sunahara, Roger K, Gereau, Robert W, and Bruchas, Michael R

Subjects
Neurosciences, Animals, Dopamine, Exocytosis, Fish Proteins, Glutamic Acid, HEK293 Cells, HeLa Cells, Humans, Male, Mice, Neural Inhibition, Optogenetics, Presynaptic Terminals, Receptors, G-Protein-Coupled, Reward, Rod Opsins, Synaptic Transmission, gamma-Aminobutyric Acid, Hela Cells, chemogenetics, inhibitory opsin, neuronal inhibition, optogenetics, synaptic inhibition, Psychology, Cognitive Sciences, Neurology & Neurosurgery
Abstract

Optical manipulations of genetically defined cell types have generated significant insights into the dynamics of neural circuits. While optogenetic activation has been relatively straightforward, rapid and reversible synaptic inhibition has proven more elusive. Here, we leveraged the natural ability of inhibitory presynaptic GPCRs to suppress synaptic transmission and characterize parapinopsin (PPO) as a GPCR-based opsin for terminal inhibition. PPO is a photoswitchable opsin that couples to Gi/o signaling cascades and is rapidly activated by pulsed blue light, switched off with amber light, and effective for repeated, prolonged, and reversible inhibition. PPO rapidly and reversibly inhibits glutamate, GABA, and dopamine release at presynaptic terminals. Furthermore, PPO alters reward behaviors in a time-locked and reversible manner in vivo. These results demonstrate that PPO fills a significant gap in the neuroscience toolkit for rapid and reversible synaptic inhibition and has broad utility for spatiotemporal control of inhibitory GPCR signaling cascades.

Published
2021

4. Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7.

Author

Harty, Breanne L, Coelho, Fernanda, Pease-Raissi, Sarah E, Mogha, Amit, Ackerman, Sarah D, Herbert, Amy L, Gereau, Robert W, Golden, Judith P, Lyons, David A, Chan, Jonah R, and Monk, Kelly R

Subjects
Myelin Sheath, Axons, Sciatic Nerve, Animals, Mice, Inbred C57BL, Mice, Knockout, Mice, Microscopy, Electron, Transmission, Models, Animal, F-Box-WD Repeat-Containing Protein 7, Brain Disorders, Neurosciences, Multiple Sclerosis, Neurodegenerative, Rare Diseases, Neurological
Abstract

In the central nervous system (CNS), oligodendrocytes myelinate multiple axons; in the peripheral nervous system (PNS), Schwann cells (SCs) myelinate a single axon. Why are the myelinating potentials of these glia so fundamentally different? Here, we find that loss of Fbxw7, an E3 ubiquitin ligase component, enhances the myelinating potential of SCs. Fbxw7 mutant SCs make thicker myelin sheaths and sometimes appear to myelinate multiple axons in a fashion reminiscent of oligodendrocytes. Several Fbxw7 mutant phenotypes are due to dysregulation of mTOR; however, the remarkable ability of mutant SCs to ensheathe multiple axons is independent of mTOR signaling. This indicates distinct roles for Fbxw7 in SC biology including modes of axon interactions previously thought to fundamentally distinguish myelinating SCs from oligodendrocytes. Our data reveal unexpected plasticity in the myelinating potential of SCs, which may have important implications for our understanding of both PNS and CNS myelination and myelin repair.

Published
2019

5. Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System

Author

Massaly, Nicolas, Copits, Bryan A, Wilson-Poe, Adrianne R, Hipólito, Lucia, Markovic, Tamara, Yoon, Hye Jean, Liu, Shiwei, Walicki, Marie C, Bhatti, Dionnet L, Sirohi, Sunil, Klaas, Amanda, Walker, Brendan M, Neve, Rachael, Cahill, Catherine M, Shoghi, Kooresh I, Gereau, Robert W, McCall, Jordan G, Al-Hasani, Ream, Bruchas, Michael R, and Morón, Jose A

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Neurosciences, Psychology, Pharmacology and Pharmaceutical Sciences, Mental Health, Drug Abuse (NIDA only), Chronic Pain, Basic Behavioral and Social Science, Substance Misuse, Pain Research, Behavioral and Social Science, Good Health and Well Being, Affect, Animals, Dynorphins, Inflammation, Mice, Mood Disorders, Neural Inhibition, Neuronal Plasticity, Neurons, Nucleus Accumbens, Pain, Rats, Receptors, Opioid, kappa, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Negative affective states affect quality of life for patients suffering from pain. These maladaptive emotional states can lead to involuntary opioid overdose and many neuropsychiatric comorbidities. Uncovering the mechanisms responsible for pain-induced negative affect is critical in addressing these comorbid outcomes. The nucleus accumbens (NAc) shell, which integrates the aversive and rewarding valence of stimuli, exhibits plastic adaptations in the presence of pain. In discrete regions of the NAc, activation of the kappa opioid receptor (KOR) decreases the reinforcing properties of rewards and induces aversive behaviors. Using complementary techniques, we report that in vivo recruitment of NAc shell dynorphin neurons, acting through KOR, is necessary and sufficient to drive pain-induced negative affect. Taken together, our results provide evidence that pain-induced adaptations in the kappa opioid system within the NAc shell represent a functional target for therapeutic intervention that could circumvent pain-induced affective disorders. VIDEO ABSTRACT.

Published
2019

7. A Potential Role for Stress-Induced Microbial Alterations in IgA-Associated Irritable Bowel Syndrome with Diarrhea

Author

Rengarajan, Sunaina, Knoop, Kathryn A., Rengarajan, Arvind, Chai, Jiani N., Grajales-Reyes, Jose G., Samineni, Vijay K., Russler-Germain, Emilie V., Ranganathan, Prabha, Fasano, Alessio, Sayuk, Gregory S., Gereau, Robert W., IV, Kau, Andrew L., Knights, Dan, Kashyap, Purna C., Ciorba, Matthew A., Newberry, Rodney D., and Hsieh, Chyi-Song

Published
2020
Full Text
View/download PDF

9. Symptom Variability and Early Symptom Regression in the MAPP Study: A Prospective Study of Urological Chronic Pelvic Pain Syndrome

Author

Stephens-Shields, Alisa J, Clemens, J Quentin, Jemielita, Thomas, Farrar, John, Sutcliffe, Siobhan, Hou, Xiaoling, Landis, J Richard, Hanno, Philip, Kirkali, Ziya, Kusek, John W, Lucia, M Scott, Moldwin, Robert M, Mullins, Chris, Pontari, Michel A, Klumpp, David J, Schaeffer, Anthony J, Apkarian, Apkar, Cella, David, Farmer, Melissa A, Fitzgerald, Colleen, Gershon, Richard, Griffith, James W, Heckman, Charles J, Jiang, Mingchen, Keefer, Laurie, Marko, Darlene S, Michniewicz, Jean, Parrish, Todd, Tu, Frank, Mayer, Emeran A, Rodríguez, Larissa V, Alger, Jeffry, Ashe-McNalley, Cody P, Ellingson, Ben, Heendeniya, Nuwanthi, Kilpatrick, Lisa, Kulbacki, Cara, Kutch, Jason, Labus, Jennifer S, Naliboff, Bruce D, Randal, Fornessa, Smith, Suzanne R, Kreder, Karl J, Bradley, Catherine S, Eno, Mary, Greiner, Kris, Luo, Yi, Lutgendorf, Susan K, O’Donnell, Michael A, Ziegler, Barbara, Clauw, Daniel J, As-Sanie, Suzie, Berry, Sandra, Grayhack, Clara, Halvorson, Megan E, Harris, Richard, Harte, Steve, Ichesco, Eric, Oldendorf, Ann, Scott, Katherine A, Williams, David A, Buchwald, Dedra, Afari, Niloofar, Krieger, John, Miller, Jane, Richey, Stephanie, Robertson, Kelly, Ross, Susan O, Spiro, Roberta, Sundsvold, TJ, Strachan, Eric, Yang, Claire C, Andriole, Gerald L, Lai, H Henry, Bristol, Rebecca L, Colditz, Graham, Deutsch, Georg, Gardner, Vivien C, Gereau, Robert W, Henderson, Jeffrey P, Hong, Barry A, Hooton, Thomas M, Ness, Timothy J, North, Carol S, Spitznagle, Theresa M, Anger, Jennifer, Freeman, Michael, Kim, Jayoung, Eilber, Karyn, Van Eyk, Jennifer, Yang, Wei, Funari, Vincent, Cha, Jeena, and Barrell, Ted

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Chronic Pain, Pain Research, Clinical Research, Urologic Diseases, Adult, Female, Humans, Male, Prospective Studies, Prostatitis, Symptom Assessment, Time Factors, MAPP Research Network, cystitis, epidemiologic research design, interstitial, pain, prostate, symptom assessment
Abstract

PurposeWe examined symptom variability in men and women with urological chronic pelvic pain syndrome. We describe symptom fluctuations as related to early symptom regression and its effect on estimated 1-year symptom change. We also describe a method to quantify patient specific symptom variability.Materials and methodsSymptoms were assessed biweekly in 424 subjects with urological chronic pelvic pain syndrome during 1 year. To evaluate the impact of early symptom regression subjects were classified as improved, no change or worse according to the rate of change using 1) all data, 2) excluding week 0 and 3) excluding weeks 0 and 2. Patient specific, time varying variability was calculated at each interval using a sliding window approach. Patients were classified as high, medium or low variability at each time and ultimately as high or low variability overall based on the variability for the majority of contacts.ResultsPrior to excluding early weeks to adjust for early symptom regression 25% to 38% and 5% to 6% of patients were classified as improved and worse, respectively. After adjustment the percent of patients who were improved or worse ranged from 15% to 25% and 6% to 9%, respectively. High and low variability phenotypes were each identified in 25% to 30% of participants.ConclusionsPatients with urological chronic pelvic pain syndrome show symptom variability. At study enrollment patients had worse symptoms on average, resulting in a regression effect that influenced the estimated proportion of those who were improved or worse. Prospective studies should include a run-in period to account for regression to the mean and other causes of early symptom regression. Further, symptom variability may be quantified and used to characterize longitudinal symptom profiles of urological chronic pelvic pain syndrome.

Published
2016

11. Relationship between Chronic Nonurological Associated Somatic Syndromes and Symptom Severity in Urological Chronic Pelvic Pain Syndromes: Baseline Evaluation of the MAPP Study

Author

Krieger, John N, Stephens, Alisa J, Landis, J Richard, Clemens, J Quentin, Kreder, Karl, Lai, H Henry, Afari, Niloofar, Rodríguez, Larissa, Schaeffer, Anthony, Mackey, Sean, Andriole, Gerald L, Williams, David A, Hanno, Philip, Kirkali, Ziya, Kusek, John W, Lucia, M Scott, Mullins, Chris, Pontari, Michel A, Klumpp, David J, Schaeffer, Anthony J, Apkarian, Apkar, Cella, David, Farmer, Melissa A, Fitzgerals, Colleen, Gershon, Richard, Griffith, James W, Heckman, Charles J, Jiang, Mingchen, Keeper, Laurie, Parrish, Todd, Tu, Frank, Marko, Darlene S, Mayer, Emeran A, Rodríguez, Larissa V, Alger, Jeffry, Ashe-McNalley, Cody P, Ellingson, Ben, Kilpatrick, Lisa, Kutch, Jason, Labus, Jennifer S, Naliboff, Bruce D, Heendeniya, Nuwanthi, Randal, Fornessa, Smith, Suzanne R, Kreder, Karl J, Bradley, Catherine S, Luo, Yi, Lutgendorf, Susan K, O'Donnell, Michael A, Eno, Mary, Greiner, Kris, Ziegler, Barbara, Clauw, Daniel J, As-Sanie, Suzie, Harris, Richard, Harte, Steve, Oldendorf, Ann, Berry, Sandra, Halvorson, Megan E, Ichesco, Eric, Scott, Katherine A, Buchwald, Dedra, Krieger, John, Miller, Jane, Strachan, Eric, Yang, Claire C, Richey, Stephanie, Ross, Susan O, Spiro, Roberta, Sundsvold, TJ, Bristol, Rebecca L, Gardner, Vivien C, Colditz, Graham, Deutsch, Georg, Gereau, Robert W, Henderson, Jeffrey P, Hone, Barry A, Hooton, Thomas M, Ness, Timothy J, North, Carol S, Sutcliffe, Siobhan, Spitznagle, Theresa M, Robinson, Nancy, Stephens, Alisa, Barrell, Ted, Hou, Xiaoling, Howard, Tamara, Wang, Yanli, and van Bokhoven, Andrie

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Depression, Urologic Diseases, Chronic Pain, Mental Health, Pain Research, Management of diseases and conditions, 7.1 Individual care needs, Chronic Disease, Cross-Sectional Studies, Cystitis, Interstitial, Female, Humans, Interdisciplinary Communication, Male, Pelvic Pain, Severity of Illness Index, Surveys and Questionnaires, Symptom Assessment, Syndrome, urinary bladder, cystitis, interstitial, male, female, questionnaires, MAPP Research Network
Abstract

PurposeWe used MAPP data to identify participants with urological chronic pelvic pain syndromes only or a chronic functional nonurological associated somatic syndrome in addition to urological chronic pelvic pain syndromes. We characterized these 2 subgroups and explored them using 3 criteria, including 1) MAPP eligibility criteria, 2) self-reported medical history or 3) RICE criteria.Materials and methodsSelf-reported cross-sectional data were collected on men and women with urological chronic pelvic pain syndromes, including predominant symptoms, symptom duration and severity, nonurological associated somatic syndrome symptoms and psychosocial factors.ResultsOf 424 participants with urological chronic pelvic pain syndromes 162 (38%) had a nonurological associated somatic syndrome, including irritable bowel syndrome in 93 (22%), fibromyalgia in 15 (4%), chronic fatigue syndrome in 13 (3%) and multiple syndromes in 41 (10%). Of 233 females 103 (44%) had a nonurological associated somatic syndrome compared to 59 of 191 males (31%) (p = 0.006). Participants with a nonurological associated somatic syndrome had more severe urological symptoms and more frequent depression and anxiety. Of 424 participants 228 (54%) met RICE criteria. Of 228 RICE positive participants 108 (47%) had a nonurological associated somatic syndrome compared to 54 of 203 RICE negative patients (28%) with a nonurological associated somatic syndrome (p < 0.001).ConclusionsNonurological associated somatic syndromes represent important clinical characteristics of urological chronic pelvic pain syndromes. Participants with a nonurological associated somatic syndrome have more severe symptoms, longer duration and higher rates of depression and anxiety. RICE positive patients are more likely to have a nonurological associated somatic syndrome and more severe symptoms. Because nonurological associated somatic syndromes are more common in women, future studies must account for this potential confounding factor in urological chronic pelvic pain syndromes.

Published
2015

16. Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia

Author

Bhuiyan, Shamsuddin A., primary, Xu, Mengyi, additional, Yang, Lite, additional, Semizoglou, Evangelia, additional, Bhatia, Parth, additional, Pantaleo, Katerina I., additional, Tochitsky, Ivan, additional, Jain, Aakanksha, additional, Erdogan, Burcu, additional, Blair, Steven, additional, Cat, Victor, additional, Mwirigi, Juliet M., additional, Sankaranarayanan, Ishwarya, additional, Tavares-Ferreira, Diana, additional, Green, Ursula, additional, McIlvried, Lisa A., additional, Copits, Bryan A., additional, Bertels, Zachariah, additional, Del Rosario, John S., additional, Widman, Allie J., additional, Slivicki, Richard A., additional, Yi, Jiwon, additional, Woolf, Clifford J., additional, Lennerz, Jochen K., additional, Whited, Jessica L., additional, Price, Theodore J., additional, Gereau, Robert W., additional, and Renthal, William, additional

Published
2023
Full Text
View/download PDF

20. Intrinsic Homeostatic Plasticity in Mouse and Human Sensory Neurons

Author

McIlvried, Lisa A., Del Rosario, John Smith, Pullen, Melanie Y., Wangzhou, Andi, Sheahan, Tayler D., Shepherd, Andrew J., Slivicki, Richard A., Lemen, John A., Price, Theodore J., Copits, Bryan A., and Gereau, Robert W.

Subjects
Article
Abstract

In response to changes in activity induced by environmental cues, neurons in the central nervous system undergo homeostatic plasticity to sustain overall network function during abrupt changes in synaptic strengths. Homeostatic plasticity involves changes in synaptic scaling and regulation of intrinsic excitability. Increases in spontaneous firing and excitability of sensory neurons are evident in some forms of chronic pain in animal models and human patients. However, whether mechanisms of homeostatic plasticity are engaged in sensory neurons under normal conditions or altered after chronic pain is unknown. Here, we showed that sustained depolarization induced by 30mM KCl induces a compensatory decrease in the excitability in mouse and human sensory neurons. Moreover, voltage-gated sodium currents are robustly reduced in mouse sensory neurons contributing to the overall decrease in neuronal excitability. Decreased efficacy of these homeostatic mechanisms could potentially contribute to the development of the pathophysiology of chronic pain.

Published
2023

22. A TRPV4-dependent neuro-immune axis in the spinal cord promotes neuropathic pain

Author

Hu, Xueming, primary, Du, Lixia, additional, Liu, Shenbin, additional, Lan, Zhou, additional, Zang, Kaikai, additional, Feng, Jing, additional, Zhao, Yonghui, additional, Yang, Xingliang, additional, Xie, Zili, additional, Wang, Peter L., additional, Ver Heul, Aaron M., additional, Chen, Lvyi, additional, Samineni, Vijay K., additional, Wang, Yan-Qing, additional, Lavine, Kory J., additional, Gereau, Robert W., additional, Wu, Gregory F., additional, and Hu, Hongzhen, additional

Published
2023
Full Text
View/download PDF

24. Relationship between Chronic Nonurological Associated Somatic Syndromes and Symptom Severity in Urological Chronic Pelvic Pain Syndromes: Baseline Evaluation of the MAPP Study

Author

Clemens, J. Quentin, Hanno, Philip, Kirkali, Ziya, Kusek, John W., Landis, J. Richard, Lucia, M. Scott, Mullins, Chris, Pontari, Michel A., Klumpp, David J., Schaeffer, Anthony J., Apkarian, Apkar (Vania), Cella, David, Farmer, Melissa A., Fitzgerals, Colleen, Gershon, Richard, Griffith, James W., Heckman, Charles J., II, Jiang, Mingchen, Keeper, Laurie, Parrish, Todd, Tu, Frank, Marko, Darlene S., Mayer, Emeran A., Rodríguez, Larissa V., Alger, Jeffry, Ashe-McNalley, Cody P., Ellingson, Ben, Kilpatrick, Lisa, Kutch, Jason, Labus, Jennifer S., Naliboff, Bruce D., Heendeniya, Nuwanthi, Randal, Fornessa, Smith, Suzanne R., Kreder, Karl J., Bradley, Catherine S., Luo, Yi, Lutgendorf, Susan K., O'Donnell, Michael A., Eno, Mary, Greiner, Kris, Ziegler, Barbara, Clauw, Daniel J., As-Sanie, Suzie, Harris, Richard, Harte, Steve, Oldendorf, Ann, Williams, David A., Berry, Sandra, Halvorson, Megan E., Ichesco, Eric, Scott, Katherine A., Buchwald, Dedra, Afari, Niloofar, Krieger, John, Miller, Jane, Strachan, Eric, Yang, Claire C., Richey, Stephanie, Ross, Susan O., Spiro, Roberta, Sundsvold, T.J., Andriole, Gerald L., Lai, H. Henry, Bristol, Rebecca L., Gardner, Vivien C., Colditz, Graham, Deutsch, Georg, Gereau, Robert W., Henderson, Jeffrey P., Hone, Barry A., Hooton, Thomas M., Ness, Timothy J., North, Carol S., Sutcliffe, Siobhan, Spitznagle, Theresa M., Robinson, Nancy, Stephens, Alisa, Barrell, Ted, Hou, Xiaoling, Howard, Tamara, Wang, Yanli, van Bokhoven, Andrie, Jonscher, Karen R., Osypuk, Andrea A., Dayton, Robert, Jr., Sullivan, Holly T., Wilson, R. Storey, Ehrlich, Garth D., Moses, Marsha A., Briscoe, David, Froehlich, John, Lee, Richard S., Solomon, Keith R., Steen, Hanno, Briscoe, Andrew C., Curatolo, Adam, Sachdev, Monisha, Mackey, Sean, Bagarinao, Epifanio, Johnson, Kevin A., Martucci, Katherine T., Foster, Lauren C., McCue, Rebecca L., Moericke, Rachel R., Nilakantan, Aneesha, Noor, Noorulain, Nickel, J. Curtis, Bavendam, Tamara G., Krieger, John N., Stephens, Alisa J., Kreder, Karl, Rodríguez, Larissa, and Schaeffer, Anthony

Published
2015
Full Text
View/download PDF

25. Cover Image

Author

Slivicki, Richard A., primary, Earnest, Tom, additional, Chang, Yu‐Hsuan, additional, Pareta, Rajesh, additional, Casey, Eric, additional, Li, Jun‐Nan, additional, Tooley, Jessica, additional, Abiraman, Kavitha, additional, Vachez, Yvan M., additional, Wolf, Drew K., additional, Sackey, Jason T., additional, Kumar Pitchai, Dhinesh, additional, Moore, Terrill, additional, Gereau, Robert W., additional, Copits, Bryan A., additional, Kravitz, Alexxai V., additional, and Creed, Meaghan C., additional

Published
2022
Full Text
View/download PDF

26. Wireless, Battery-Free Implants for Electrochemical Catecholamine Sensing and Optogenetic Stimulation

Author

Stuart, Tucker, primary, Jeang, William J., additional, Slivicki, Richard A., additional, Brown, Bobbie J., additional, Burton, Alex, additional, Brings, Victoria E., additional, Alarcón-Segovia, Lilian C., additional, Agyare, Prophecy, additional, Ruiz, Savanna, additional, Tyree, Amanda, additional, Pruitt, Lindsay, additional, Madhvapathy, Surabhi, additional, Niemiec, Martin, additional, Zhuang, James, additional, Krishnan, Siddharth, additional, Copits, Bryan A., additional, Rogers, John A., additional, Gereau, Robert W., additional, Samineni, Vijay K., additional, Bandodkar, Amay J., additional, and Gutruf, Philipp, additional

Published
2022
Full Text
View/download PDF

29. Oral oxycodone self‐administration leads to features of opioid misuse in male and female mice

Author

Slivicki, Richard A., primary, Earnest, Tom, additional, Chang, Yu‐Hsuan, additional, Pareta, Rajesh, additional, Casey, Eric, additional, Li, Jun‐Nan, additional, Tooley, Jessica, additional, Abiraman, Kavitha, additional, Vachez, Yvan M., additional, Wolf, Drew K., additional, Sackey, Jason T., additional, Kumar Pitchai, Dhinesh, additional, Moore, Terrill, additional, Gereau, Robert W., additional, Copits, Bryan A., additional, Kravitz, Alexxai V., additional, and Creed, Meaghan C., additional

Published
2022
Full Text
View/download PDF

30. Author Correction: Wireless multilateral devices for optogenetic studies of individual and social behaviors

Author

Yang, Yiyuan, primary, Wu, Mingzheng, additional, Vázquez-Guardado, Abraham, additional, Wegener, Amy J., additional, Grajales-Reyes, Jose G., additional, Deng, Yujun, additional, Wang, Taoyi, additional, Avila, Raudel, additional, Moreno, Justin A., additional, Minkowicz, Samuel, additional, Dumrongprechachan, Vasin, additional, Lee, Jungyup, additional, Zhang, Shuangyang, additional, Legaria, Alex A., additional, Ma, Yuhang, additional, Mehta, Sunita, additional, Franklin, Daniel, additional, Hartman, Layne, additional, Bai, Wubin, additional, Han, Mengdi, additional, Zhao, Hangbo, additional, Lu, Wei, additional, Yu, Yongjoon, additional, Sheng, Xing, additional, Banks, Anthony, additional, Yu, Xinge, additional, Donaldson, Zoe R., additional, Gereau, Robert W., additional, Good, Cameron H., additional, Xie, Zhaoqian, additional, Huang, Yonggang, additional, Kozorovitskiy, Yevgenia, additional, and Rogers, John A., additional

Published
2022
Full Text
View/download PDF

34. Oral oxycodone self-administration leads to features of opioid addiction in male and female mice

Author

Slivicki, Richard A., primary, Earnest, Tom, additional, Chang, Yu-Hsuan, additional, Pareta, Rajesh, additional, Casey, Eric, additional, Li, Jun-Nan, additional, Tooley, Jessica, additional, Abiraman, Kavitha, additional, Vachez, Yvan M., additional, Wolfe, Drew K., additional, Sackey, Jason T., additional, Gereau, Robert W., additional, Copits, Bryan A., additional, Kravitz, Alexxai V., additional, and Creed, Meaghan C., additional

Published
2022
Full Text
View/download PDF

41. IL-33 signaling in sensory neurons promotes dry skin itch

Author

Trier, Anna M., primary, Mack, Madison R., additional, Fredman, Avery, additional, Tamari, Masato, additional, Ver Heul, Aaron M., additional, Zhao, Yonghui, additional, Guo, Changxiong J., additional, Avraham, Oshri, additional, Ford, Zachary K., additional, Oetjen, Landon K., additional, Feng, Jing, additional, Dehner, Carina, additional, Coble, Dean, additional, Badic, Asima, additional, Joshita, Satoru, additional, Kubo, Masato, additional, Gereau, Robert W., additional, Alexander-Brett, Jennifer, additional, Cavalli, Valeria, additional, Davidson, Steve, additional, Hu, Hongzhen, additional, Liu, Qin, additional, and Kim, Brian S., additional

Published
2022
Full Text
View/download PDF

46. Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors

Author

Tavares-Ferreira, Diana, primary, Shiers, Stephanie, additional, Ray, Pradipta R., additional, Wangzhou, Andi, additional, Jeevakumar, Vivekanand, additional, Sankaranarayanan, Ishwarya, additional, Cervantes, Anna M., additional, Reese, Jeffrey C., additional, Chamessian, Alexander, additional, Copits, Bryan A., additional, Dougherty, Patrick M., additional, Gereau, Robert W., additional, Burton, Michael D., additional, Dussor, Gregory, additional, and Price, Theodore J., additional

Published
2022
Full Text
View/download PDF

50. Oral oxycodone self‐administration leads to features of opioid misuse in male and female mice.

Author

Slivicki, Richard A., Earnest, Tom, Chang, Yu‐Hsuan, Pareta, Rajesh, Casey, Eric, Li, Jun‐Nan, Tooley, Jessica, Abiraman, Kavitha, Vachez, Yvan M., Wolf, Drew K., Sackey, Jason T., Kumar Pitchai, Dhinesh, Moore, Terrill, Gereau, Robert W., Copits, Bryan A., Kravitz, Alexxai V., and Creed, Meaghan C.

Subjects
OPIOID abuse, OXYCODONE, OXYCODONE abuse, DRUG accessibility, VETERINARY drugs
Abstract

Use of prescription opioids, particularly oxycodone, is an initiating factor driving the current opioid epidemic. There are several challenges with modelling oxycodone abuse. First, prescription opioids including oxycodone are orally self‐administered and have different pharmacokinetics and dynamics than morphine or fentanyl, which have been more commonly used in rodent research. This oral route of administration determines the pharmacokinetic profile, which then influences the establishment of drug‐reinforcement associations in animals. Moreover, the pattern of intake and the environment in which addictive drugs are self‐administered are critical determinants of the levels of drug intake, of behavioural sensitization and of propensity to relapse behaviour. These are all important considerations when modelling prescription opioid use, which is characterized by continuous drug access in familiar environments. Thus, to model features of prescription opioid use and the transition to abuse, we designed an oral, homecage‐based oxycodone self‐administration paradigm. Mice voluntarily self‐administer oxycodone in this paradigm without any taste modification such as sweeteners, and the majority exhibit preference for oxycodone, escalation of intake, physical signs of dependence and reinstatement of seeking after withdrawal. In addition, a subset of animals demonstrate drug taking that is resistant to aversive consequences. This model is therefore translationally relevant and useful for studying the neurobiological substrates of prescription opioid abuse. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results