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2. The effectiveness of coronary computed tomography angiography and functional testing for the diagnosis of obstructive coronary artery disease: results from the individual patient data Collaborative Meta-Analysis of Cardiac CT (COME-CCT)

Author

Schlattmann, Peter, Wieske, Viktoria, Bressem, Keno K., Götz, Theresa, Schuetz, Georg M., Andreini, Daniele, Pontone, Gianluca, Alkadhi, Hatem, Hausleiter, Jörg, Zimmermann, Elke, Gerber, Bernhard, Shabestari, Abbas A., Meijs, Matthijs F. L., Sato, Akira, Øvrehus, Kristian A., Jenkins, Shona M. M., Knuuti, Juhani, Hamdan, Ashraf, Halvorsen, Bjørn A., Mendoza-Rodriguez, Vladimir, Rixe, Johannes, Wan, Yung-Liang, Langer, Christoph, Leschka, Sebastian, Martuscelli, Eugenio, Ghostine, Said, Tardif, Jean-Claude, Sánchez, Alejandra Rodríguez, Haase, Robert, and Dewey, Marc

Published
2024
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4. Impact of early versus class I–triggered surgery on postoperative survival in severe aortic regurgitation: An observational study from the Aortic Valve Insufficiency and Ascending Aorta Aneurysm International Registry

Author

Hanet, Vincent, Schäfers, Hans-Joachim, Lansac, Emmanuel, de Kerchove, Laurent, El Hamansy, Ismail, Vojácek, Jan, Contino, Monica, Pouleur, Anne-Catherine, Beauloye, Christophe, Pasquet, Agnès, Vanoverschelde, Jean-Louis, Vancraeynest, David, and Gerber, Bernhard L.

Published
2024
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5. Long-term course of ambulatory patients with COVID-19 initially treated with enoxaparin vs no anticoagulation: final analysis of the OVID (enoxaparin for outpatients with COVID-19) randomized trial

Author

Barco, Stefano, Voci, Davide, Held, Ulrike, Sebastian, Tim, Bingisser, Roland, Colucci, Giuseppe, Duerschmied, Daniel, Frenk, André, Gerber, Bernhard, Götschi, Andrea, Konstantinides, Stavros V., Mach, François, Robert-Ebadi, Helia, Rosemann, Thomas, Simon, Noemi R., Spechbach, Hervé, Spirk, David, Stortecky, Stefan, Vaisnora, Lukas, Righini, Marc, Kucher, Nils, Zetzsche, Stéphanie Roth, Spescha, Rebecca, Leeger, Claudia, Butscheid, Yulia, Probst, Eliane, Micieli, Evy, Forgo, Gabor, Johner, Fabian, Grigorean, Alexandru, Vatsakis, Georgios, Lang, Dagmar Keller, Speck, Silvana Rampini, Hasse, Barbara, Rueegg, Marco, Arnold, Isabelle, Nickel, Christian, Busch, Jeannette, Blondon, Marc, Glauser, Frédéric, Cittone, Micol G., Kessler, Chiara, Gjermeni, Diona, Olivier, Christoph B., Gauchel, Nadine, Biever, Paul, Hobohm, Lukas, Becker, Dorothea, Schindewolf, Marc, Kuenzi, Arnaud, Ulrich, Silvia, Fumagalli, Riccardo M., Bikdeli, Behnood, Gerardi, Teresa, Klok, Frederikus A., Wolf, Simon, and Wyss, Dörte

Published
2024
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10. Enoxaparin for symptomatic COVID-19 managed in the ambulatory setting: An individual patient level analysis of the OVID and ETHIC trials

Author

Barco, Stefano, Virdone, Saverio, Götschi, Andrea, Ageno, Walter, Arcelus, Juan I., Bingisser, Roland, Colucci, Giuseppe, Cools, Frank, Duerschmied, Daniel, Gibbs, Harry, Fumagalli, Riccardo M., Gerber, Bernhard, Haas, Sylvia, Himmelreich, Jelle C.L., Hobbs, Richard, Hobohm, Lukas, Jacobson, Barry, Kayani, Gloria, Lopes, Renato D., MacCallum, Peter, Micieli, Evy, Righini, Marc, Robert-Ebadi, Helia, Rocha, Ana Thereza, Rosemann, Thomas, Sawhney, Jitendra, Schellong, Sebastian, Sebastian, Tim, Spirk, David, Stortecky, Stefan, Turpie, Alexander G.G., Voci, Davide, Kucher, Nils, Pieper, Karen, Held, Ulrike, and Kakkar, Ajay K.

Published
2023
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12. Bloodstream infections in allogeneic haematopoietic cell recipients from the Swiss Transplant Cohort Study: trends of causative pathogens and resistance rates

Author

Sava, Mihaela, Bättig, Veronika, Gerull, Sabine, Passweg, Jakob R., Khanna, Nina, Garzoni, Christian, Gerber, Bernhard, Mueller, Nicolas J., Schanz, Urs, Berger, Christoph, Chalandon, Yves, van Delden, Christian, Neofytos, Dionysios, Stampf, Susanne, Franzeck, Fabian C., and Weisser, Maja

Published
2023
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16. Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19 (OVID): a randomised, open-label, parallel-group, multicentre, phase 3 trial

Author

Barco, Stefano, Voci, Davide, Held, Ulrike, Sebastian, Tim, Bingisser, Roland, Colucci, Giuseppe, Duerschmied, Daniel, Frenk, André, Gerber, Bernhard, Götschi, Andrea, Konstantinides, Stavros V, Mach, François, Robert-Ebadi, Helia, Rosemann, Thomas, Simon, Noemi R, Spechbach, Hervé, Spirk, David, Stortecky, Stefan, Vaisnora, Lukas, Righini, Marc, Kucher, Nils, Roth Zetzsche, Stéphanie, Spescha, Rebecca, Leeger, Claudia, Butscheid, Yulia, Probst, Eliane, Micieli, Evy, Forgo, Gabor, Johner, Fabian, Grigorean, Alexandru, Vatsakis, Georgios, Keller Lang, Dagmar, Rampini Speck, Silvana, Hasse, Barbara, Rueegg, Marco, Arnold, Isabelle, Nickel, Christian, Busch, Jeannette, Blondon, Marc, Glauser, Frédéric, Cittone, Micol G, Kessler, Chiara, Gjermeni, Diona, Olivier, Christoph B, Gauchel, Nadine, Biever, Paul, Hobohm, Lukas, Becker, Dorothea, Schindewolf, Marc, Kuenzi, Arnaud, and Ulrich, Silvia

Published
2022
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19. Genetic and phenotypic attributes of splenic marginal zone lymphoma

Author

Bonfiglio, Ferdinando, Bruscaggin, Alessio, Guidetti, Francesca, Terzi di Bergamo, Lodovico, Faderl, Martin, Spina, Valeria, Condoluci, Adalgisa, Bonomini, Luisella, Forestieri, Gabriela, Koch, Ricardo, Piffaretti, Deborah, Pini, Katia, Pirosa, Maria Cristina, Cittone, Micol Giulia, Arribas, Alberto, Lucioni, Marco, Ghilardi, Guido, Wu, Wei, Arcaini, Luca, Baptista, Maria Joao, Bastidas, Gabriela, Bea, Silvia, Boldorini, Renzo, Broccoli, Alessandro, Buehler, Marco Matteo, Canzonieri, Vincenzo, Cascione, Luciano, Ceriani, Luca, Cogliatti, Sergio, Corradini, Paolo, Derenzini, Enrico, Devizzi, Liliana, Dietrich, Sascha, Elia, Angela Rita, Facchetti, Fabio, Gaidano, Gianluca, Garcia, Juan Fernando, Gerber, Bernhard, Ghia, Paolo, Gomes da Silva, Maria, Gritti, Giuseppe, Guidetti, Anna, Hitz, Felicitas, Inghirami, Giorgio, Ladetto, Marco, Lopez-Guillermo, Armando, Lucchini, Elisa, Maiorana, Antonino, Marasca, Roberto, Matutes, Estella, Meignin, Veronique, Merli, Michele, Moccia, Alden, Mollejo, Manuela, Montalban, Carlos, Novak, Urban, Oscier, David Graham, Passamonti, Francesco, Piazza, Francesco, Pizzolitto, Stefano, Rambaldi, Alessandro, Sabattini, Elena, Salles, Gilles, Santambrogio, Elisa, Scarfò, Lydia, Stathis, Anastasios, Stüssi, Georg, Geyer, Julia T., Tapia, Gustavo, Tarella, Corrado, Thieblemont, Catherine, Tousseyn, Thomas, Tucci, Alessandra, Vanini, Giorgio, Visco, Carlo, Vitolo, Umberto, Walewska, Renata, Zaja, Francesco, Zenz, Thorsten, Zinzani, Pier Luigi, Khiabanian, Hossein, Calcinotto, Arianna, Bertoni, Francesco, Bhagat, Govind, Campo, Elias, De Leval, Laurence, Dirnhofer, Stefan, Pileri, Stefano A., Piris, Miguel A., Traverse-Glehen, Alexandra, Tzankov, Alexander, Paulli, Marco, Ponzoni, Maurilio, Mazzucchelli, Luca, Cavalli, Franco, Zucca, Emanuele, and Rossi, Davide

Published
2022
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21. Accuracy of Diagnosing Heparin-Induced Thrombocytopenia

Author

Larsen, Emil List, primary, Nilius, Henning, additional, Studt, Jan-Dirk, additional, Tsakiris, Dimitrios A., additional, Greinacher, Andreas, additional, Mendez, Adriana, additional, Schmidt, Adrian, additional, Wuillemin, Walter A., additional, Gerber, Bernhard, additional, Vishnu, Prakash, additional, Graf, Lukas, additional, Kremer Hovinga, Johanna A., additional, Goetze, Jens P., additional, Bakchoul, Tamam, additional, and Nagler, Michael, additional

Published
2024
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22. Circulating tumor DNA for comprehensive noninvasive monitoring of lymphoma treated with ibrutinib plus nivolumab

Author

Bruscaggin, Alessio, di Bergamo, Lodovico Terzi, Spina, Valeria, Hodkinson, Brendan, Forestieri, Gabriela, Bonfiglio, Ferdinando, Condoluci, Adalgisa, Wu, Wei, Pirosa, Maria C., Faderl, Martin R., Koch, Ricardo, Schaffer, Michael, Alvarez, John D., Fourneau, Nele, Gerber, Bernhard, Stussi, Georg, Zucca, Emanuele, Balasubramanian, Sriram, and Rossi, Davide

Published
2021
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23. Markers of Myocardial Damage Predict Mortality in Patients With Aortic Stenosis

Author

Kwak, Soongu, Everett, Russell J., Treibel, Thomas A., Yang, Seokhun, Hwang, Doyeon, Ko, Taehoon, Williams, Michelle C., Bing, Rong, Singh, Trisha, Joshi, Shruti, Lee, Heesun, Lee, Whal, Kim, Yong-Jin, Chin, Calvin W.L., Fukui, Miho, Al Musa, Tarique, Rigolli, Marzia, Singh, Anvesha, Tastet, Lionel, Dobson, Laura E., Wiesemann, Stephanie, Ferreira, Vanessa M., Captur, Gabriella, Lee, Sahmin, Schulz-Menger, Jeanette, Schelbert, Erik B., Clavel, Marie-Annick, Park, Sung-Ji, Rheude, Tobias, Hadamitzky, Martin, Gerber, Bernhard L., Newby, David E., Myerson, Saul G., Pibarot, Phillipe, Cavalcante, João L., McCann, Gerry P., Greenwood, John P., Moon, James C., Dweck, Marc R., and Lee, Seung-Pyo

Published
2021
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24. Diagnosis and risk stratification in hypertrophic cardiomyopathy using machine learning wall thickness measurement: a comparison with human test-retest performance

Author

Augusto, João B, Davies, Rhodri H, Bhuva, Anish N, Knott, Kristopher D, Seraphim, Andreas, Alfarih, Mashael, Lau, Clement, Hughes, Rebecca K, Lopes, Luís R, Shiwani, Hunain, Treibel, Thomas A, Gerber, Bernhard L, Hamilton-Craig, Christian, Ntusi, Ntobeko A B, Pontone, Gianluca, Desai, Milind Y, Greenwood, John P, Swoboda, Peter P, Captur, Gabriella, Cavalcante, João, Bucciarelli-Ducci, Chiara, Petersen, Steffen E, Schelbert, Erik, Manisty, Charlotte, and Moon, James C

Published
2021
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25. Historic characteristics and mortality of patients in the Swiss Amyloidosis Registry

Author

Brouwers, Sofie; https://orcid.org/0000-0002-7081-4881, Heimgartner, Raphael, Laptseva, Natallia, Aguzzi, Adriano; https://orcid.org/0000-0002-0344-6708, Ehl, Niklas F, Fehr, Thomas; https://orcid.org/0000-0003-1668-1800, Hitz, Felicitas; https://orcid.org/0000-0001-5653-5117, Jung, Hans H, Kälin, Joel, Manz, Markus G; https://orcid.org/0000-0002-4676-7931, Müllhaupt, Beat; https://orcid.org/0000-0002-9020-8192, Ruschitzka, Frank; https://orcid.org/0000-0001-5972-0596, Seeger, Harald; https://orcid.org/0000-0003-1552-7983, Stussi, Georg; https://orcid.org/0000-0002-1667-0637, Zweier, Markus; https://orcid.org/0000-0001-8290-0413, Flammer, Andreas J; https://orcid.org/0000-0002-1373-0630, Gerber, Bernhard, Schwotzer, Rahel, Brouwers, Sofie; https://orcid.org/0000-0002-7081-4881, Heimgartner, Raphael, Laptseva, Natallia, Aguzzi, Adriano; https://orcid.org/0000-0002-0344-6708, Ehl, Niklas F, Fehr, Thomas; https://orcid.org/0000-0003-1668-1800, Hitz, Felicitas; https://orcid.org/0000-0001-5653-5117, Jung, Hans H, Kälin, Joel, Manz, Markus G; https://orcid.org/0000-0002-4676-7931, Müllhaupt, Beat; https://orcid.org/0000-0002-9020-8192, Ruschitzka, Frank; https://orcid.org/0000-0001-5972-0596, Seeger, Harald; https://orcid.org/0000-0003-1552-7983, Stussi, Georg; https://orcid.org/0000-0002-1667-0637, Zweier, Markus; https://orcid.org/0000-0001-8290-0413, Flammer, Andreas J; https://orcid.org/0000-0002-1373-0630, Gerber, Bernhard, and Schwotzer, Rahel

Abstract

AIMS OF THE STUDY: Systemic amyloidoses are rare protein-folding diseases with heterogeneous, often nonspecific clinical presentations. To better understand systemic amyloidoses and to apply state-of-the-art diagnostic pathways and treatment, the interdisciplinary Amyloidosis Network was founded in 2013 at University Hospital Zurich. In this respect, a registry was implemented to study the characteristics and life expectancy of patients with amyloidosis within the area covered by the network. Patient data were collected retrospectively for the period 2005–2014 and prospectively from 2015 onwards. METHODS: Patients aged 18 years or older diagnosed with any subtype of systemic amyloidosis were eligible for inclusion if they were treated in one of the four referring centres (Zurich, Chur, St Gallen, Bellinzona). Baseline data were captured at the time of diagnosis. Follow-up data were assessed half-yearly for the first two years, then annually. RESULTS: Between January 2005 and March 2020, 247 patients were screened, and 155 patients with confirmed systemic amyloidosis were included in the present analysis. The most common amyloidosis type was light-chain (49.7%, n = 77), followed by transthyretin amyloidosis (40%, n = 62) and amyloid A amyloidosis (5.2%, n = 8). Most patients (61.9%, n = 96) presented with multiorgan involvement. Nevertheless, single organ involvement was seen in all types of amyloidosis, most commonly in amyloid A amyloidosis (75%, n = 6). The median observation time of the surviving patients was calculated by the reverse Kaplan-Meier method and was 3.29 years (95% confidence interval [CI] 2.33–4.87); it was 4.87 years (95% CI 3.14–7.22) in light-chain amyloidosis patients and 1.85 years (95% CI 1.48–3.66) in transthyretin amyloidosis patients, respectively. The 1-, 3- and 5-year survival rates were 87.0% (95% CI 79.4–95.3%), 68.5% (95% CI 57.4–81.7%) and 66.0% (95% CI 54.6–79.9%) respectively for light-chain amyloidosis patients and 91.2% (95% CI 83

Published
2024

26. Carbohydrate antigen 125: a useful marker of congestion, fibrosis, and prognosis in heart failure with preserved ejection fraction.

Author

Menghoum, Nassiba, Badii, Maria Chiara, Deltombe, Matthieu, Lejeune, Sibille, Roy, Clotilde, Vancraeynest, David, Pasquet, Agnes, Gerber, Bernhard L., Horman, Sandrine, Gruson, Damien, Beauloye, Christophe, and Pouleur, Anne‐Catherine

Subjects
HEART failure, BRAIN natriuretic factor, VENTRICULAR ejection fraction, CARDIAC magnetic resonance imaging, FIBROBLAST growth factors, PROPORTIONAL hazards models
Abstract

Aims: Heart failure (HF) with preserved ejection fraction (HFpEF) is a disease associated with high morbidity and mortality, for which it is difficult to identify patients with the poorest prognosis in routine clinical practice. Carbohydrate antigen 125 (CA 125) has been shown to be a potential marker of congestion and prognosis in HF. We sought to better characterize HFpEF patients with high CA 125 levels by using a multimodal approach. Methods and results: We prospectively enrolled 139 HFpEF patients (78 ± 8 years; 60% females) and 25 controls matched for age and sex (77 ± 5 years; 60% females). They underwent two‐dimensional echocardiography, cardiac magnetic resonance with late gadolinium enhancement [including extracellular volume (ECV) measurement], and serum measurements of CA 125 level. The primary endpoint of the study was a composite of all‐cause mortality or first HF hospitalization. The prognostic impact of CA 125 was determined using Cox proportional hazard models. Median CA 125 levels were significantly higher in HFpEF patients compared with controls [CA 125: 23.5 (14.5–44.7) vs. 14.6 (10.3–21.0) U/mL, P = 0.004]. CA 125 levels were positively correlated with a congestion marker [N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) levels, Pearson's r = 0.37, P < 0.001] and markers of cardiac fibrosis estimated by both ECV (Pearson's r = 0.26, P = 0.003) and fibroblast growth factor 23 levels (Pearson's r = 0.50, P < 0.001). Over a median follow‐up of 49 (22–64) months, 97 HFpEF patients reached the composite endpoint. Even after adjustment for the Meta‐Analysis Global Group in Chronic risk score, a CA 125 level ≥35 U/mL was still a significant predictor of the composite endpoint [hazard ratio (HR): 1.58 (1.04–2.41), P = 0.032] and more particularly of HF hospitalization [HR: 1.81 (1.13–2.92), P = 0.014]. In contrast, NT‐proBNP levels were not an independent predictor. Conclusions: CA 125 levels were significantly higher in HFpEF patients compared with controls matched for age and sex and were associated with markers of congestion and cardiac fibrosis. CA 125 levels were a strong and independent predictor of HF hospitalization in HFpEF patients. These data suggest a potential value of CA 125 as a biomarker for staging and risk prediction in HFpEF. [ABSTRACT FROM AUTHOR]

Published
2024
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27. SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule

Author

Aboubakar, Frank, Acid, Souad, Amini, Nadia, Bailly, Sarah, Beauloye, Christophe, Castanares-Zapatero, Diego, Coche, Emmanuel, Collienne, Christine, Cornette, Pascale, De Brauwer, Isabelle, Dechamps, Mélanie, Dupriez, Florence, Froidure, Antoine, Garnir, Quentin, Gerber, Bernhard, Ghaye, Benoît, Gilard, Isabelle, Gohy, Sophie, Grégoire, Charles, Hantson, Philippe, Jacquet, Luc-Marie, Kabamba, Benoit, Kautbally, Shakeel, Lanthier, Nicolas, Larbaoui, Fatima, Liistro, Giuseppe, Maes, Frédéric, Montiel, Virginie, Mwenge, Benny, Pierard, Sophie, Pilette, Charles, Pouleur, Anne Catherine, Sogorb, Amaury, Starkel, Peter, Rodriguez-Villalobos, Hector, Thoma, Maximilien, Van Caeneghem, Olivier, Vancraeynest, David, Werion, Alexis, Belkhir, Leila, Perrot, Marie, Schmit, Gregory, Aydin, Selda, Chen, Zhiyong, Penaloza, Andrea, De Greef, Julien, Yildiz, Halil, Pothen, Lucie, Yombi, Jean Cyr, Dewulf, Joseph, Scohy, Anais, Gérard, Ludovic, Wittebole, Xavier, Laterre, Pierre-François, Miller, Sara E., Devuyst, Olivier, Jadoul, Michel, and Morelle, Johann

Published
2020
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28. Historic characteristics and mortality of patients in the Swiss Amyloidosis Registry

Author

Brouwers, Sofie, primary, Heimgartner, Raphael, additional, Laptseva, Natallia, additional, Aguzzi, Adriano, additional, Ehl, Niklas F., additional, Fehr, Thomas, additional, Hitz, Felicitas, additional, Jung, Hans H., additional, Kälin, Joel, additional, Manz, Markus G., additional, Müllhaupt, Beat, additional, Ruschitzka, Frank, additional, Seeger, Harald, additional, Stussi, Georg, additional, Zweier, Markus, additional, Flammer, Andreas J., additional, Gerber, Bernhard, additional, and Schwotzer, Rahel, additional

Published
2024
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30. Cardiovascular multimodality imaging in women. A scientific statement of the European Association of Cardiovascular Imaging (EACVI) of the ESC

Author

Almeida, Ana G, primary, Grapsa, Julia, additional, Gemelli, Alessia, additional, Bucciarelli-Ducci, Chiara, additional, Gerber, Bernhard, additional, Ajmone-Marsan, Nina, additional, Bernard, Anne, additional, Donal, Erwan, additional, Dweck, Marc R, additional, Haugaa, Kristina H, additional, Hristova, Krassimira, additional, Maceira, Alicia, additional, Mandoli, Giulia Elena, additional, Mulvagh, Sharon, additional, Morrone, Doralisa, additional, Plonska-Gosciniak, Edyta, additional, Sade, Leyla Elif, additional, Schivalkar, Bharati, additional, Schulz-Menger, Jeanette, additional, Shaw, Leslee, additional, Sitges, Marta, additional, von Kemp, Berlinde, additional, Pinto, Fausto J, additional, Edvardsen, Thor, additional, Petersen, Steffen E, additional, and Cosyns, Bernard, additional

Published
2024
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33. Cardiac structure, function and coronary anatomy 10 years after isolated contemporary adjuvant radiotherapy in breast cancer patients with low cardiovascular baseline risk

Author

Krug, Pauline, primary, Geets, Xavier, additional, Berlière, Martine, additional, Duhoux, François, additional, Beauloye, Christophe, additional, Pasquet, Agnès, additional, Vancraeynest, David, additional, Pouleur, Anne-Catherine, additional, and Gerber, Bernhard L, additional

Published
2023
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36. Assessment of viability

Author

Pierard, Luc A., additional, Gargiulo, Paola, additional, Perrone-Filardi, Pasquale, additional, Gerber, Bernhard, additional, and Selvanayagam, Joseph B., additional

Published
2021
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39. Multiview Machine Learning Using an Atlas of Cardiac Cycle Motion

Author

Puyol-Antón, Esther, Sinclair, Matthew, Gerber, Bernhard, Amzulescu, Mihaela Silvia, Langet, Hélène, De Craene, Mathieu, Aljabar, Paul, Schnabel, Julia A., Piro, Paolo, King, Andrew P., Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Pop, Mihaela, editor, Sermesant, Maxime, editor, Jodoin, Pierre-Marc, editor, Lalande, Alain, editor, Zhuang, Xiahai, editor, Yang, Guang, editor, Young, Alistair, editor, and Bernard, Olivier, editor

Published
2018
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41. Platelet Acetyl-CoA Carboxylase Phosphorylation: A Risk Stratification Marker That Reveals Platelet-Lipid Interplay in Coronary Artery Disease Patients

Author

Kautbally, Shakeel, Lepropre, Sophie, Onselaer, Marie-Blanche, Le Rigoleur, Astrid, Ginion, Audrey, De Meester de Ravenstein, Christophe, Ambroise, Jerome, Boudjeltia, Karim Z., Octave, Marie, Wéra, Odile, Hego, Alexandre, Pincemail, Joël, Cheramy-Bien, Jean-Paul, Huby, Thierry, Giera, Martin, Gerber, Bernhard, Pouleur, Anne-Catherine, Guigas, Bruno, Vanoverschelde, Jean-Louis, Kefer, Joelle, Bertrand, Luc, Oury, Cécile, Horman, Sandrine, and Beauloye, Christophe

Published
2019
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43. Cardiac structure, function, and coronary anatomy 10 years after isolated contemporary adjuvant radiotherapy in breast cancer patients with low cardiovascular baseline risk.

Author

Krug, Pauline, Geets, Xavier, Berlière, Martine, Duhoux, François, Beauloye, Christophe, Pasquet, Agnès, Vancraeynest, David, Pouleur, Anne-Catherine, and Gerber, Bernhard L

Subjects
HEART anatomy, HEART physiology, RISK assessment, CROSS-sectional method, PEARSON correlation (Statistics), RADIOTHERAPY, T-test (Statistics), STATISTICAL significance, RESEARCH funding, BREAST tumors, BLOOD vessels, COMPUTED tomography, RESEARCH evaluation, CARDIOVASCULAR diseases risk factors, TREATMENT effectiveness, MAGNETIC resonance imaging, PEPTIDE hormones, MANN Whitney U Test, CHI-squared test, DESCRIPTIVE statistics, LONGITUDINAL method, PEPTIDES, WALKING, INTRACLASS correlation, CANCER patient psychology, CORONARY angiography, EXERCISE tests, DATA analysis software, TIME, ECHOCARDIOGRAPHY, REGRESSION analysis, INTER-observer reliability
Abstract

Aims The effects of isolated contemporary low-dose breast cancer (BC) radiotherapy (RT) on the heart remain poorly understood. This study aims to assess the long-term impacts of BC-RT on cardiac structure and function. Methods and results Seventy-six women (62 ± 7 years) without history of prior heart disease, who had undergone RT for either first left (n = 36) or right (n = 40) BC, without additional medical oncology therapy apart from hormonal treatment 11 ± 1 years earlier, underwent transthoracic echocardiography, cardiac magnetic resonance imaging (CMR), computed tomography coronary angiography (CTCA), NT-proBNP, and a 6-min walk test (6MWT). They were compared with 54 age-matched healthy female controls. By CTCA, 68% of BC patients exhibited no or very mild coronary disease, while only 11% had moderate stenosis (50–69%) and 3% had significant stenosis (>70%). Despite slightly reduced regional echocardiographic midventricular strains, BC patients exhibited similar global left and right ventricular volumes, ejection fractions, and global strains by echocardiography and CMR as controls. Mitral E/e′ ratios were slightly higher, and mitral deceleration times were slightly lower, but NT-proBNP was similar to controls. Also, 6MWT was normal. None had late gadolinium enhancement, and extracellular volume fraction was similar in BC (28 ± 3 vs. 29 ± 3, P = 0.15) and controls. No differences were observed relative to dose or side of RT. Conclusion Aside from minor alterations of regional strains and diastolic parameters, women who received isolated RT for BC had low prevalence of coronary disease, normal global systolic function, NT-proBNP, and exercise capacity and showed no structural changes by CMR, refuting significant long-term cardiotoxicity in such low-risk patients. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Cardiovascular multimodality imaging in women: a scientific statement of the European Association of Cardiovascular Imaging of the European Society of Cardiology.

Author

Almeida, Ana G, Grapsa, Julia, Gimelli, Alessia, Bucciarelli-Ducci, Chiara, Gerber, Bernhard, Ajmone-Marsan, Nina, Bernard, Anne, Donal, Erwan, Dweck, Marc R, Haugaa, Kristina H, Hristova, Krassimira, Maceira, Alicia, Mandoli, Giulia Elena, Mulvagh, Sharon, Morrone, Doralisa, Plonska-Gosciniak, Edyta, Sade, Leyla Elif, Shivalkar, Bharati, Schulz-Menger, Jeanette, and Shaw, Leslee

Subjects
CARDIOVASCULAR disease diagnosis, CARDIOVASCULAR disease treatment, RISK assessment, CARDIOVASCULAR diseases, DISEASE management, MENOPAUSE, ARTERIAL dissections, CARDIOVASCULAR diseases risk factors, ESTROGEN, TAKOTSUBO cardiomyopathy, DISEASES, WOMEN'S health, PREGNANCY complications
Abstract

Cardiovascular diseases (CVD) represent an important cause of mortality and morbidity in women. It is now recognized that there are sex differences regarding the prevalence and the clinical significance of the traditional cardiovascular (CV) risk factors as well as the pathology underlying a range of CVDs. Unfortunately, women have been under-represented in most CVD imaging studies and trials regarding diagnosis, prognosis, and therapeutics. There is therefore a clear need for further investigation of how CVD affects women along their life span. Multimodality CV imaging plays a key role in the diagnosis of CVD in women as well as in prognosis, decision-making, and monitoring of therapeutics and interventions. However, multimodality imaging in women requires specific consideration given the differences in CVD between the sexes. These differences relate to physiological changes that only women experience (e.g. pregnancy and menopause) as well as variation in the underlying pathophysiology of CVD and also differences in the prevalence of certain conditions such as connective tissue disorders, Takotsubo, and spontaneous coronary artery dissection, which are all more common in women. This scientific statement on CV multimodality in women, an initiative of the European Association of Cardiovascular Imaging of the European Society of Cardiology, reviews the role of multimodality CV imaging in the diagnosis, management, and risk stratification of CVD, as well as highlights important gaps in our knowledge that require further investigation. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Repurposing the β3-Adrenergic Receptor Agonist Mirabegron in Patients With Structural Cardiac Disease

Author

Balligand, Jean-Luc, primary, Brito, Dulce, additional, Brosteanu, Oana, additional, Casadei, Barbara, additional, Depoix, Christophe, additional, Edelmann, Frank, additional, Ferreira, Vanessa, additional, Filippatos, Gerasimos, additional, Gerber, Bernhard, additional, Gruson, Damien, additional, Hasenclever, Dirk, additional, Hellenkamp, Kristian, additional, Ikonomidis, Ignatios, additional, Krakowiak, Bartosz, additional, Lhommel, Renaud, additional, Mahmod, Masliza, additional, Neubauer, Stefan, additional, Persu, Alexandre, additional, Piechnik, Stefan, additional, Pieske, Burkert, additional, Pieske-Kraigher, Elisabeth, additional, Pinto, Fausto, additional, Ponikowski, Piotr, additional, Senni, Michele, additional, Trochu, Jean-Noël, additional, Van Overstraeten, Nancy, additional, Wachter, Rolf, additional, and Pouleur, Anne-Catherine, additional

Published
2023
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50. HL-370 Fragmentóme Profiling Reveals Distinct Molecular Subgroups of Classic Hodgkin Lymphoma

Author

Bergamo, Lodovico Terzi di, Pirosa, Maria Cristina, Bruscaggin, Alessio, Salehi, Matin, Spina, Valeria, Pini, Katia, Bocchetta, Simone, Giordano, Claudia, Condouci, Adalgisa, Forestieri, Gabriela, Piffaretti, Deborah, de Almeida, Joyce Marques, Annunziata, Salvatore, Bergesio, Fabrizio, Borsatti, Eugenio, Bulian, Pietro, Chauvie, Stephane, Cuzzocrea, Marco, Trani, Martina Di, Gerber, Bernhard, Kurlapski, Michal, Moccia, Alden, Moia, Riccardo, Rinaldi, Andrea, Rodari, Marcello, Romanowicz, Grzegorz, Sacchetti, Gian Mauro, Stasia, Alessandra, Stathis, Anastasios, Stuessi, Georg, Zangrilli, Ilaria, Larocca, Luigi Maria, Pinto, Antonello, Santoro, Armando, Cavalli, Franco, Zucca, Emanuele, Gattei, Valter, Zaucha, Jan Maciej, Stella, Carmelo Carlo, Hohaus, Stefan, Gaidano, Gianluca, Ceriani, Luca, and Rossi, Davide

Published
2022
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