36 results on '"Gerasimova TP"'
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2. Structural flexibility of favipiravir and its structural analogues in solutions: experimental and computational insight.
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Gerasimova TP, Zagidullin AA, Nikolaeva AN, Fayzullin RR, Saitova AM, Miluykov VA, Grimme S, and Katsyuba SA
- Abstract
Combined UV-vis and quantum chemical studies of the structural flexibility and tautomerism of 6-R-3-hydroxy-2-pyrazine carboxamides in solutions revealed that their keto-enol transformations are accompanied by the deprotonation of enol tautomers and the formation of the corresponding anionic species. Both the solvent and the 6-R substituent strongly influence the relative abundance of the above forms in solutions. Anions are not formed in 1,2-dichloroethane (DCE), but the probability of deprotonation in neutral water and N , N -dimethylformamide (DMF) increases in the order R = H < F < NO
2 . Only enol tautomers of all solutes are found in DCE. DMF stabilizes keto forms only moderately and assists much strongly in the deprotonation of all three compounds. Water tends to stabilize both keto tautomers and deprotonated anions: the keto form dominates in the case of R = H (antiviral drug T-1105), the anions are found exclusively for R = NO2 , and the aqueous solution of another antiviral drug, favipiravir (R = F), contains both the keto tautomer and the anionic form. The results of quantum chemical free energy calculations are in agreement with the experimental observations.- Published
- 2024
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3. Specificity of hexarhenium cluster anions for synthesis of Mn 2+ -based nanoparticles with lamellar shape and pH-induced leaching for specific organ selectivity in MRI contrasting.
- Author
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Akhmadeev BS, Nizameev IR, Kholin KV, Voloshina AD, Gerasimova TP, Gubaidullin AT, Romashchenko AV, Zavjalov EL, Kashnik IV, Brylev KA, and Mustafina AR
- Subjects
- Mice, Animals, Liver, Anions, Hydrogen-Ion Concentration, Magnetic Resonance Imaging, Nanoparticles chemistry
- Abstract
The present work demonstrates the structure variation of hexarhenium anionic cluster units [{Re
6 S8 }(CN)(6- n ) (OH)n ]4- (n = 0, 2, 4) as the strategy to develop Mn2+ -containing nanoparticles (NPs) exhibiting pH-dependent leaching. The dicyanotetrahydroxo complex [{Re6 S8 }(CN)2 (OH)4 ]4- is the optimal for the synthesis of the Mn2+ -based NPs with a lamellar shape exhibiting the pH-dependent aggregation and magnetic relaxation behavior. The pH-dependent behavior of the NPs derives from the easy protonation of the apical hydroxo ligands of [{Re6 S8 }(CN)2 (OH)4 ]4- cluster, which triggers partial leaching of Mn2+ ions and aggregation of the NPs driven by the surface neutralization. The in vivo MRI scanning of the mice intravenously injected with the NPs indicates the preferable accumulation of the lamellar NPs within mouse intestine over liver and kidneys. This differs from the spherical NPs constructed from [{Re6 Se8 }(CN)6 ]4- units, which provide the preferable brightening of mouse liver over kidneys and intestine., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)- Published
- 2024
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4. Linkage of the Dinuclear Gold(I) Complex Luminescence and Origin of Endocyclic Amino Group of Cyclic P 2 N 2 -Bridging Ligands.
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Strelnik ID, Dayanova IR, Faizullin BA, Mustafina AR, Gerasimova TP, Kolesnikov IE, Islamov DR, Litvinov IA, Voloshina AD, Sapunova AS, Gubaidullin AT, Musina EI, and Karasik AA
- Abstract
Gold(I) complexes of LAu
2 Cl2 composition based on P2 N2 ligands, namely 1,5-diaza-3,7-diphosphacyclooctanes, containing ethylpyridyl substituents at the phosphorus atoms and sp2 - or sp3 -hybridized endocyclic nitrogen atoms were synthesized. The SCXRD analysis indicated the strong impact of the geometry of the nitrogen atom on the structure and conformational flexibility of the complexes. The N -aryl substituted ligand with the planar endocyclic nitrogen atom provides higher flexibility of the complex and an ability to bind the solvent molecules in the "host-guest" mode, whereas that kind of behavior is forbidden for the complex with an N -alkyl substituted ligand with a pyramidal nitrogen atom. The substituents at nitrogen atoms also control the origin of the emission, which is phosphorescence for the N -aryl substituted complex and fluorescence for the N -alkylaryl substituted complex. The phosphorescent gold(I) complex displays high cytotoxicity without selectivity toward the m-HeLa and normal cells, but the core-shell nanoparticles formed on the base of the complex demonstrate reduced cytotoxicity. The luminescence of the NPs allows tracking the complexes in the cell samples.- Published
- 2023
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5. Cobalt(II) coordination to an N 4 -acenaphthene-based ligand and its sodium complex.
- Author
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Khrizanforova VV, Fayzullin RR, Bogomyakov AS, Morozov VI, Batulin RG, Gerasimova TP, Islamov DR, and Budnikova YH
- Abstract
A new bifunctional N
4 -ligand was obtained via the condensation reaction of acenaphthenequinone and 2-picolylamine. A peculiarity of this synthesis is the formation of a new intramolecular C-C bond during the reaction. The structure and redox properties of the ligand were studied. The anion-radical form of the ligand was prepared via the chemical reduction of the latter with metallic sodium as well as in situ via its electrochemical reduction in a solution. The sodium salt prepared was structurally characterized using single-crystal X-ray diffraction (XRD). New cobalt complexes with the ligand in neutral and anion-radical forms were synthesized and further studied. As a result, three new homo- and heteroleptic cobalt(II) complexes were obtained, in which the cobalt atom demonstrates different modes of coordination with the ligand. Cobalt(II) complex CoL2 with two monoanionic ligands was prepared by the electrochemical reduction of a related L2 CoBr2 complex or by treating cobalt(II) bromide with the sodium salt. XRD was used to study the structures of all cobalt complexes prepared. Magnetic and electron paramagnetic resonance studies were performed: CoII ion states with S = 3/2 and S = 1/2 were found for the complexes. A quantum-chemical study confirmed that the spin density is mainly located at the cobalt center.- Published
- 2023
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6. Chemical and Electrochemical Reductions of Monoiminoacenaphthenes.
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Khrizanforova VV, Fayzullin RR, Gerasimova TP, Khrizanforov MN, Zagidullin AA, Islamov DR, Lukoyanov AN, and Budnikova YH
- Subjects
- Oxidation-Reduction, Anions chemistry, Cations chemistry, Sodium
- Abstract
Redox properties of monoiminoacenaphthenes (MIANs) were studied using various electrochemical techniques. The potential values obtained were used for calculating the electrochemical gap value and corresponding frontier orbital difference energy. The first-peak-potential reduction of the MIANs was performed. As a result of controlled potential electrolysis, two-electron one-proton addition products were obtained. Additionally, the MIANs were exposed to one-electron chemical reduction by sodium and NaBH
4 . Structures of three new sodium complexes, three products of electrochemical reduction, and one product of the reduction by NaBH4 were studied using single-crystal X-ray diffraction. The MIANs reduced electrochemically by NaBH4 represent salts, in which the protonated MIAN skeleton acts as an anion and Bu4 N+ or Na+ as a cation. In the case of sodium complexes, the anion radicals of MIANs are coordinated with sodium cations into tetranuclear complexes. The photophysical and electrochemical properties of all reduced MIAN products, as well as neutral forms, were studied both experimentally and quantum-chemically.- Published
- 2023
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7. Synthesis, Structure, and Electrochemical Properties of 2,3,4,5-Tetraphenyl-1-Monophosphaferrocene Derivatives.
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Zagidullin AA, Lakomkina AR, Khrizanforov MN, Fayzullin RR, Kholin KV, Gerasimova TP, Shekurov RP, Bezkishko IA, and Miluykov VA
- Abstract
Heteroleptic 2,3,4,5-tetraphenyl-1-monophosphaferrocene [FeCp(η
5 -PC4 Ph4 )] was obtained at a 62% yield through the reaction of lithium 2,3,4,5-tetraphenyl-1-monophosphacyclopentadienide Li(PC4 Ph4 ) ( 1 ) with [FeCp(η6 -C6 H5 CH3 )][PF6 ]. The structure of 1-monophosphaferrocene 2 and its W(CO)5 -complex 3 were confirmed by multinuclear NMR and single-crystal X-ray diffraction study and further supported by DFT calculations. Cyclic voltammetry demonstrated that [FeCp(η5 -PC4 Ph4 )] 2 has a quasi-reversible oxidation wave. The comparison of the properties of phosphaferrocene 2 with those of W(CO)5 -complex 3 shows the possibility of changing the coordination type during oxidation.- Published
- 2023
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8. Green Emissive Copper(I) Coordination Polymer Supported by the Diethylpyridylphosphine Ligand as a Luminescent Sensor for Overheating Processes.
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Enikeeva KR, Shamsieva AV, Strelnik AG, Fayzullin RR, Zakharychev DV, Kolesnikov IE, Dayanova IR, Gerasimova TP, Strelnik ID, Musina EI, Karasik AA, and Sinyashin OG
- Abstract
Tertiary diethylpyridylphosphine was synthesized by the reaction of pyridylphosphine with bromoethane in a suberbasic medium. The reaction of phosphine with the copper(I) iodide led to the formation of a copper(I) coordination polymer, which, according to the X-ray diffraction data, has an intermediate structure with a copper-halide core between the octahedral and stairstep geometries of the Cu
4 I4 clusters. The obtained coordination polymer exhibits a green emission in the solid state, which is caused by the3 (M+X)LCT transitions. The heating up of the copper(I) coordination polymer to 138.5 °C results in its monomerization and the formation of a new solid-state phase. The new phase exhibits a red emission, with the emission band maximum at 725 nm. According to the experimental data and quantum chemical computations, it was concluded that depolymerization probably leads to a complex that is formed with the octahedral structure of the copper-halide core. The resulting solid-state phase can be backward-converted to the polymer phase via recrystallization from the acetone or DMF. Therefore, the obtained coordination polymer can be considered a sensor or detector for the overheating of processes that should be maintained at temperatures below 138 °C (e.g., engines, boiling liquids, solar heat systems, etc.).- Published
- 2023
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9. Ferrocene-based P -chiral amidophosphinate: stereoselective synthesis and X-ray structural study.
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Shekurov RP, Zagidullin AA, Khrizanforov MN, Islamov DR, Gerasimova TP, Akhmatkhanova FF, and Miluykov VA
- Abstract
Racemic and enantiopure ferrocene-based P -chiral amidophosphinates have been simply and stereoselectively synthesized by ortho -lithiation of rac - or ( R )-Ugi's amine and further reaction with amidochlorophenylphosphinate Cl-P(O)(Ph)NEt
2 . This is the first example of an asymmetric reaction of ortho -lithiated Ugi's amine with tetracoordinated phosphorus(V) chlorides. The structures of rac - and ( R )-Ugi's amine ferrocenyl(phenyl)phosphinic acid N , N -diethylamide have been extensively studied experimentally (NMR, X-ray analysis, electrochemistry). The CV first peak refers to the oxidation of the amine fragment, which is clearly seen when ( R )-Ugi's amine ferrocenyl(phenyl)phosphinic acid N , N -diethylamide reacts with anhydrous acid. The addition of two equivalents of CF3 COOH leads to the protonation of nitrogen atoms, and a classical reversible wave of oxidation of Fe(II) to Fe(III) is observed.- Published
- 2022
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10. Conductive Mediators in Oxidation Based on Ferrocene Functionalized Phosphonium Ionic Liquids.
- Author
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Ermolaev VV, Kadyrgulova LR, Khrizanforov MN, Gerasimova TP, Baembitova GR, Lazareva AA, and Miluykov VA
- Subjects
- Metallocenes, Salts chemistry, Oxidation-Reduction, Ionic Liquids chemistry
- Abstract
Herein, the synthesis of ferrocene-containing salts is presented. Acylation of ferrocene (Fc) according to the Friedel-Crafts method led to ω-bromoacyl ferrocenes. The ω-bromoacyl ferrocenes were subsequently introduced to quaternization reaction with tri- tert -butyl phosphine, which resulted in phosphonium salts. Obtained phosphonium salts were characterized by physical methods. The electrochemical properties of phosphonium salts were studied by cyclic voltammetry (CV). It was found that the replacement of n -butyl fragments at the phosphorus atom by tert -butyl leads to a more anodic potential shift. In contrast to isolobal structures Fc-C(O)(CH
2 )n P+ ( n -Bu)3 X- and Fc-(CH2 )n+1 P+ ( n -Bu)3 X- , the CV curves of Fc-C(O)(CH2 )n P+ ( t -Bu)3 X- and Fc-(CH2 )n+1 P+ ( t -Bu)3 X- did not show a large discrepancy between forward and reverse currents. The transformation of the C=O groups to CH2 fragments had a significant effect on the electrochemical properties of ferrocene salts, the oxidation potential of which is close to that of pure ferrocene.- Published
- 2022
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11. The Phosphinate Group in the Formation of 2D Coordination Polymer with Sm(III) Nodes: X-ray Structural, Electrochemical and Mössbauer Study.
- Author
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Shekurov RP, Khrizanforov MN, Zagidullin AA, Zinnatullin AL, Kholin KV, Ivshin KA, Gerasimova TP, Sirazieva AR, Kataeva ON, Vagizov FG, and Miluykov VA
- Subjects
- Metallocenes, X-Rays, Oxidation-Reduction, Polymers chemistry, Ferric Compounds
- Abstract
A coordination polymer has been synthesized using ferrocene-based ligand-bearing phosphinic groups of 1,1'-ferrocene-diyl-bis( H -phosphinic acid)), and samarium (III). The coordination polymer's structure was studied by both single-crystal and powder XRD, TG, IR, and Raman analyses. For the first time, the Mössbauer effect studies were performed on ferrocenyl phosphinate and the polymer based on it. Additionally, the obtained polymer was studied by the method of cyclic and differential pulse voltammetry. It is shown that it has the most positive potential known among ferrocenyl phosphinate-based coordination polymers and metal-organic frameworks. Using the values of the oxidation potential, the polymer was oxidized and the ESR method verified the oxidized Fe(III) form in the solid state. Additionally, the effect of the size of the phosphorus atom substituent of the phosphinate group on the dimension of the resulting coordination compounds is shown.
- Published
- 2022
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12. Thermodynamics of trans/gauche conformational equilibria and vibrational spectra of 1,2-dihaloethanes in various media.
- Author
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Katsyuba SA and Gerasimova TP
- Subjects
- Reproducibility of Results, Molecular Conformation, Thermodynamics, Solvents, Vibration
- Abstract
The recently developed efficient protocols to implicit [Grimme et al., J. Phys. Chem. A 125, 4039-4054 (2021)] and explicit quantum mechanical modeling of non-rigid molecules in solution [Katsyuba et al., J. Phys. Chem. B 124, 6664-6670 (2020)] are used to describe conformational equilibria of 1,2-dichloroethane and 1,2-dibromoethane in various media. Two approaches for evaluation of trans/gauche free energy differences, ΔG
t-g , are compared: (a) direct ΔGt-g computation in implicit solution; (b) the use, together with experimental intensities, of infrared absorption coefficients and Raman scattering cross sections computed for each explicitly modeled solution. The same cluster model of a solute surrounded by the first solvation shell of solvent molecules was used to simulate both Raman and IR spectra. The good agreement between the two approaches indicates the reliability of both methods. The importance of using correct absorption coefficients and Raman scattering factors for each medium is discussed. The ΔGt-g estimates from both implicit and explicit solvation simulations were combined with experimentally measured enthalpy differences ΔHt-g available in the literature to obtain condensed-state ΔSt-g estimates.- Published
- 2022
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13. Comparison of crystal structure and DFT calculations of triferrocenyl trithiophosphite's conformance.
- Author
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Shekurov RP, Khrizanforov MN, Bezkishko IA, Gerasimova TP, Zagidullin AA, Islamov DR, and Miluykov VA
- Abstract
A triferrocenyl trithiophosphite was studied by X-ray single-crystal diffraction. Triferrocenyl trithiophosphite has nine axes of internal rotation: three P-S bonds, three C-S bonds and three Fe-cyclopentadienyl axes. Rotation around the P-S bonds results in a totally asymmetric structure with three ferrocenylthio groups exhibiting different orientations towards the phosphorus lone electron pair (LEP). A comparison of DFT calculations and X-ray diffraction data is presented, herein we show which conformations are preferred for a given ligand., (Copyright © 2022, Shekurov et al.)
- Published
- 2022
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14. Deep-Blue Emissive Copper(I) Complexes Based on P-Thiophenylethyl-Substituted Cyclic Bisphosphines Displaying Photoinduced Structural Transformations of the Excited States.
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Strelnik ID, Dayanova I, Gerasimova TP, Katsyuba SA, Kolesnikov IE, Kalinichev A, Shmelev A, Islamov DR, Lönnecke P, Hey-Hawkins E, Musina EI, and Karasik AA
- Abstract
A synthetic method for a primary 2-(thiophen-2'-yl)ethylphosphine was developed. The reaction of thiophenylethylphosphine with paraformaldehyde and primary arylamines leads to the formation of cyclic bisphosphines, namely, 1,5-di(aryl)-3,7-bis(thiophenylethyl)-1,5-diaza-3,7-diphosphacyclooctane (aryl = phenyl, p -tolyl). The obtained bisphosphines form cationic bis-P,P-chelate complexes with copper(I) tetrafluoroborate, which were structurally characterized by NMR spectroscopy, mass spectrometry, and elemental and XRD analyses. Surprisingly, the copper(I) complexes display a multiband emission in the solid state with maxima at 355-360, 425-430, and 480-490 nm and nanosecond lifetimes (1.2-1.4 ns) upon a 335 nm excitation. The excitation of the complexes at 360 nm at room temperature results in a deep-blue emission at 425-430 nm and a tail at 460-490 nm. A temperature decrease leads to an increased intensity of the emission band at 480 nm, while the luminescence lifetimes insignificantly increased up to 14 ns. Quantum chemical calculations explain the observed unusual luminescent behavior by the existence of "undistorted" and "flattened" singlet excited states of copper(I) complexes at room temperature and at 77 K, respectively.
- Published
- 2022
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15. Synthesis and electrochemical properties of 3,4,5-tris(chlorophenyl)-1,2-diphosphaferrocenes.
- Author
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Zagidullin AA, Akhmatkhanova FF, Khrizanforov MN, Fayzullin RR, Gerasimova TP, Bezkishko IA, and Miluykov VA
- Abstract
A novel representative of sodium 3,4,5-triaryl-1,2-diphosphacyclopentadienide containing a chloro substituent in the meta -position of the aryl groups was obtained with a high yield based on the reaction of tributyl(1,2,3-triarylcyclopropenyl)phosphonium bromide and sodium polyphosphides. Further reaction of sodium 3,4,5-tris(3-chlorophenyl)-1,2-diphosphacyclopentadienide with [FeCp(η
6 -C6 H5 CH3 )][PF6 ] complex gives a new 3,4,5-tris(3-chlorophenyl)-1,2-diphosphaferrocene. The electrochemical properties of 3,4,5-tris(3-chlorophenyl)-1,2-diphosphaferrocene were studied and compared to 3,4,5-tris(4-chlorophenyl)-1,2-diphosphaferrocene. It was found that the position of the chlorine atom on the aryl fragment has an influence on the reduction potential of 1,2-diphosphaferrocenes, while the oxidation potentials do not change., (Copyright © 2022, Zagidullin et al.)- Published
- 2022
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16. Molecular and Nano-Structural Optimization of Nanoparticulate Mn 2+ -Hexarhenium Cluster Complexes for Optimal Balance of High T 1 - and T 2 -Weighted Contrast Ability with Low Hemoagglutination and Cytotoxicity.
- Author
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Akhmadeev BS, Nizameev IR, Kholin KV, Voloshina AD, Gerasimova TP, Gubaidullin AT, Kadirov MK, Ismaev IE, Brylev KA, Zairov RR, and Mustafina AR
- Abstract
The present work introduces rational design of nanoparticulate Mn(II)-based contrast agents through both variation of the μ
3 (inner) ligands within a series of hexarhenium cluster complexes [{Re6 (μ3 -Q)8 }(CN)6 ]4 - (Re6 Q8 , Q = S2- , Se2- or Te2- ) and interfacial decoration of the nanoparticles (NPs) K4-2x Mnx Re6 Q8 ( x = 1.3 - 1.8) by a series of pluronics (F-68, P-123, F-127). The results highlight an impact of the ligand and pluronic for the optimal colloid behavior of the NPs allowing high colloid stability in ambient conditions and efficient phase separation under the centrifugation. It has been revealed that the K4-2x Mnx Re6 Se8 NPs and those decorated by F-127 are optimal from the viewpoint of magnetic relaxivities r1 and r2 (8.9 and 10.9 mM-1 s-1 , respectively, at 0.47 T) and low hemoagglutination activity. The insignificant leaching of Mn2+ ions from the NPs correlates with their insignificant effect on the cell viability of both M-HeLa and Chang Liver cell lines. The T1 - and T2 -weighted contrast ability of F-127-K4-2x Mnx Re6 Q8 NPs was demonstrated through the measurements of phantoms at whole body 1.5 T scanner.- Published
- 2022
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17. Temperature-sensitive emission of dialkylaminostyrylhetarene dyes and their incorporation into phospholipid aggregates: Applicability for thermal sensing and cellular uptake behavior.
- Author
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Akhmadeev BS, Gerasimova TP, Gilfanova AR, Katsyuba SA, Islamova LN, Fazleeva GM, Kalinin AA, Daminova AG, Fedosimova SV, Amerhanova SK, Voloshina AD, Tanysheva EG, Sinyashin OG, and Mustafina AR
- Subjects
- Fluorescent Dyes, Phosphatidylcholines, Temperature, Water, Coloring Agents, Phospholipids
- Abstract
A series of dialkylaminostyrylhetarene dyes constructed from electron-rich and electron-deficient moieties of various structures connected via vinylene π-bridges are introduced as temperature-sensitive luminophores. The temperature dependent emission of the dyes in the acidified dichloromethane solutions derives from temperature-induced shift of the equilibrium between neutral and protonated forms of the dyes. The heating-induced blue shift and intensification of emission of neutral form of the dyes make them a promising basis for development of nanoparticles exhibiting temperature-sensitivity in aqueous solutions at pH typical of biological liquids. Hydrophobicity-driven incorporation of the water insoluble dyes into L-α-phosphatidylcholine(PC)-based bilayers allows to obtain water dispersible dye-PC aggregates, and to follow their emission in the aqueous solutions. Structure of the dyes has strong impact on the efficacy of the dyes incorporation into the PC-based bilayers, temperature sensitivity of emission of the dye-PC aggregates and its reversibility under the heating/cooling cycles. This enables structural optimization of the dyes in order to obtain the dye-PC species demonstrating maximal temperature dependence and reversibility of their luminescence in aqueous solutions. The selected leader exhibits low cytotoxicity exemplified for M-HeLa and Chang Liver cell lines, while the efficient cell internalization of the dye, manifested in the staining of the cell cytoplasm, opens further opportunities for biosensing applications., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier B.V. All rights reserved.)
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- 2022
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18. Computer-aided simulation of infrared spectra of ethanol conformations in gas, liquid and in CCl 4 solution.
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Katsyuba SA, Gerasimova TP, Spicher S, Bohle F, and Grimme S
- Abstract
The recently developed efficient protocol combining implicit and explicit, accurate quantum-mechanical modeling of the condensed state (Katsyuba et al., J. Chem. Phys. 155, 024507 [2021]) is used to describe the IR spectra of liquid ethanol and its solutions in CCl
4 . The relative abundance of the anti and gauche conformers of ethanol is shown to increase from ~40:60 in the gas phase to ~55:45 in the liquid phase. In spite of a moderate impact of media effects on the conformational composition of the liquid, the solvent strongly influences vibrational frequencies, IR intensities, and normal modes of each conformer, producing qualitatively different spectra compared to the gas phase and CCl4 solution. Further, these solvent effects affecting IR frequencies and intensities depend not only on the conformation of the solvated molecule but also on the solvating species. Nevertheless, vibrational frequencies of anti and gauche conformers of liquid ethanol and its several isotopomers practically coincide with each other. Convenient liquid-state conformational markers in the fingerprint region of IR spectra are revealed for the hydroxyl-deuterated species: CH3 CH2 OD, CH3 CHDOD, CH3 CD2 OD, and CD3 CD2 OD., (© 2021 Wiley Periodicals LLC.)- Published
- 2022
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19. Structure impact on photodynamic therapy and cellular contrasting functions of colloids constructed from dimeric Au(I) complex and hexamolybdenum clusters.
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Faizullin BA, Strelnik ID, Dayanova IR, Gerasimova TP, Kholin KV, Nizameev IR, Voloshina AD, Gubaidullin AT, Fedosimova SV, Mikhailov MA, Sokolov MN, Sibgatullina GV, Samigullin DV, Petrov KA, Karasik AA, and Mustafina AR
- Subjects
- Colloids, Luminescence, Polymers, Water, Photochemotherapy
- Abstract
Electrostatically driven self-assembly of [Au
2 L2 ]2+ (L is cyclic PNNP ligand) with [{Mo6 I8 }(L')6 ]2- (L' = I- , CH3 COO- ) in aqueous solutions is introduced as facile route for combination of therapeutic and cellular contrasting functions within heterometallic colloids (Mo6 -Au2 ). The nature of L' affects the size and aggregation behavior of crystalline Mo6 -Au2 aggregates, which in turn affect the luminescence of the cluster units incorporated into Mo6 -Au2 colloids. The spin trap facilitated electron spin resonance spectroscopy technique indicates that the level of ROS generated by Mo6 -Au2 colloids is also affected by their size. Both (L' = I- , CH3 COO- ) Mo6 -Au2 colloids undergo cell internalization, which is enhanced by their assembly with poly-DL-lysine (PL) for L' = CH3 COO- , but remains unchanged for L' = I- . The colloids PL-Mo6 -Au2 (L' = CH3 COO- ) are visualized as huge crystalline aggregates both outside and inside the cell cytoplasm by confocal microscopy imaging of the incubated cells, while the smaller sized (30-50 nm) PL-Mo6 -Au2 (L' = I- ) efficiently stain the cell nuclei. Quantitative colocalization analysis of PL-Mo6 -Au2 (L' = CH3 COO- ) in lysosomal compartments points to the fast endo-lysosomal escape of the colloids followed by their intracellular aggregation. The cytotoxicity of PL-Mo6 -Au2 differs from that of Mo6 and Au2 blocks, predominantly acting through apoptotic pathway. The photodynamic therapeutic effect of the PL-Mo6 -Au2 colloids on the cancer cells correlates with their intracellular trafficking and aggregation., (Copyright © 2021 Elsevier B.V. All rights reserved.)- Published
- 2021
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20. Revisiting conformations of methyl lactate in water and methanol.
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Katsyuba SA, Spicher S, Gerasimova TP, and Grimme S
- Abstract
The recently developed efficient protocols to implicit [Grimme et al., J. Phys. Chem. A 125, 4039-4054 (2021)] and explicit quantum mechanical modeling of non-rigid molecules in solution [Katsyuba et al., J. Phys. Chem. B 124, 6664-6670 (2020)] are applied to methyl lactate (ML). Building upon this work, a new combination scheme is proposed to incorporate solvation effects for the computation of infrared (IR) absorption spectra. Herein, Boltzmann populations calculated for implicitly solvated single conformers are used to weight the IR spectra of explicitly solvated clusters with a size of typically ten solvent molecules, i.e., accounting for the first solvation shell. It is found that in water and methanol, the most abundant conformers of ML are structurally modified relative to the gas phase, where the major form is ML1, in which the syn conformation of the -OH moiety is stabilized by a OH⋯O=C intramolecular hydrogen bond (HB). In solution, this syn conformation transforms to the gauche form because the intramolecular HB is disrupted by explicit water molecules that form intermolecular HBs with the hydroxyl and carbonyl groups. Similar changes induced by the gas-solution transition are observed for the minor conformers, ML2 and/or ML3, characterized by OH⋯OCH
3 intramolecular HB in the gas phase. The relative abundance of ML1 is shown to decrease from ∼96% in gas to ∼51% in water and ∼92% in methanol. The solvent strongly influences frequencies, IR intensities, and normal modes, resulting in qualitatively different spectra compared to the gas phase. Some liquid-state conformational markers in the fingerprint region of IR spectra are revealed.- Published
- 2021
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21. Assembly of Heterometallic AuICu 2 I 2 Cores on the Scaffold of NPPN-Bridging Cyclic Bisphosphine.
- Author
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Dayanova IR, Shamsieva AV, Strelnik ID, Gerasimova TP, Kolesnikov IE, Fayzullin RR, Islamov DR, Saifina AF, Musina EI, Hey-Hawkins E, and Karasik AA
- Abstract
The row of metallocyclic dinuclear gold(I) complexes with cyclic diphosphines, namely, P-pyridylethyl-substituted 1,5-diaza-3,7-diphosphacyclooctanes, has been obtained. Further interaction of the dinuclear gold(I) complexes with copper(I) iodide gave the first examples of hexanuclear Au
I /CuI complexes containing two unusual trinuclear AuICu2 I2 fragments. The structures of di- and hexanuclear complexes were confirmed by NMR spectroscopy, ESI mass spectrometry, elemental analysis, and single-crystal X-ray diffraction. All of the obtained complexes are moderate emitters in the solid state. Dinuclear gold(I) complexes displayed a greenish emission with the maxima in the emission spectra at ca. 550 nm. The obtained hexanuclear heterobimetallic AuI /CuI complexes are triplet solid-state blue emitters with the maximum in the emission spectra at 463 and 484 nm. According to the TD-DFT calculations, the observed emission of all studied complexes had a triplet origin and was caused by the3 CC or3 (MLCT) T1 → S0 transitions for dinuclear and hexanuclear complexes, respectively.- Published
- 2021
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22. Synthesis, structure, and electrochemical properties of 4,5-diaryl-1,2,3-triphosphaferrocenes and the first example of multi(phosphaferrocene).
- Author
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Petrov AV, Zagidullin AA, Bezkishko IA, Khrizanforov MN, Kholin KV, Gerasimova TP, Ivshin KA, Shekurov RP, Katsyuba SA, Kataeva ON, Budnikova YH, and Miluykov VA
- Abstract
The reaction between aryl substituted sodium 1,2,3-triphospholides or disodium bis(1,2,3-triphospholide) and [Fe(η6-(C6H5CH3)Cp]+[PF6]- in boiling diglyme results in pure 1,2,3-triphosphaferrocenes 1-3 or bis(1,2,3-triphosphaferrocene) 4, respectively, in good yields. The structure of all obtained 1,2,3-triphosphaferrocenes 1-4 has been extensively studied experimentally (NMR, UV-Vis spectroscopy, and X-ray analysis for 1 and 4) and quantum chemically. The electrochemical properties of 1,2,3-triphosphaferrocenes 1-4 in the solid state were studied for the first time and a reversible one-electron oxidation (E1/2 = 0.52-0.92 V vs. Fc+/Fc) was demonstrated for 1, 3, and 4. In the case of 1,4-bis(5-phenyl-4-(1,2,3-triphospaferrocenyl))benzene 4, consecutive oxidation in the solid state is observed in contrast to other 1,2,3-triphosphaferrocenes 1-3. According to the ESR data, the g-factor of the oxidized bis(1,2,3-triphosphaferrocene), 4 (g = 2.12) is different from the g-factors of oxidized 1,2,3-triphosphaferrocenes 1-3 (g = 2.01). This is the first example of multi(ferrocenyl) systems based on the phosphaferrocene motif, which in turn opens up a new fundamental platform for the preparation of compounds with stimuli-responsive properties.
- Published
- 2020
- Full Text
- View/download PDF
23. Triple-bridged helical binuclear copper(i) complexes: Head-to-head and head-to-tail isomerism and the solid-state luminescence.
- Author
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Shamsieva AV, Musina EI, Gerasimova TP, Strelnik ID, Strelnik AG, Kolesnikov IE, Kalinichev AA, Islamov DR, Samigullina AI, Lönnecke P, Katsyuba SA, Hey-Hawkins E, Karasik AA, and Sinyashin OG
- Abstract
A family of helical dinuclear copper(i) pyridylphospholane complexes [Cu
2 L3 X]X (X = BF4 - , Cl- and Br- ) was prepared. The family includes the first examples of this type of complex based on copper(i) chloride and copper(i) bromide. The two isomers typical of this class of compounds, namely head-to-head and head-to-tail complexes, were studied in solution by spectroscopic and optical methods, and in the solid state by X-ray diffraction. Furthermore, the solid-state luminescence of the complexes at different temperatures was studied, and the results were interpreted using quantum-chemical calculations. It was shown that the luminescence of the complexes is attributed to the3 (M + X)LCT transitions.- Published
- 2020
- Full Text
- View/download PDF
24. Fast and Accurate Quantum Chemical Modeling of Infrared Spectra of Condensed-Phase Systems.
- Author
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Katsyuba SA, Spicher S, Gerasimova TP, and Grimme S
- Abstract
An efficient approach for an accurate quantum mechanical (QM) modeling of infrared (IR) spectra of condensed-phase systems is described. An ensemble of energetically low-lying cluster structures of a solute molecule surrounded by an explicit shell of solvent molecules is efficiently generated at the semiempirical tight-binding QM level and then reoptimized at the density functional theory level of theory. The IR spectrum of the solvated molecule is obtained as a thermodynamic average of harmonically computed QM spectra for all significantly populated cluster structures. The accuracy of such simulations in comparison to experimental data for some organic compounds and their solutions is shown to be the same or even better than the corresponding QM computations of the gas-phase IR spectrum for the isolated molecule.
- Published
- 2020
- Full Text
- View/download PDF
25. Synthesis, structure-activity relationship and biological evaluation of tetracationic gemini Dabco-surfactants for transdermal liposomal formulations.
- Author
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Pashirova TN, Sapunova AS, Lukashenko SS, Burilova EA, Lubina AP, Shaihutdinova ZM, Gerasimova TP, Kovalenko VI, Voloshina AD, Souto EB, and Zakharova LY
- Subjects
- Administration, Cutaneous, Anti-Bacterial Agents pharmacokinetics, Aza Compounds chemistry, Bacterial Outer Membrane Proteins, Cell Line, Cell Survival, Cyclooctanes chemistry, Dose-Response Relationship, Drug, Fungi drug effects, Gram-Negative Bacteria drug effects, Gram-Positive Bacteria drug effects, Humans, Hydrophobic and Hydrophilic Interactions, Liposomes chemistry, Liposomes pharmacokinetics, Micelles, Microbial Sensitivity Tests, Particle Size, Piperazines chemical synthesis, Piperazines pharmacokinetics, Skin drug effects, Structure-Activity Relationship, Surface-Active Agents chemistry, Surface-Active Agents pharmacology, Anti-Bacterial Agents pharmacology, Liposomes pharmacology, Piperazines chemistry, Piperazines pharmacology, Technology, Pharmaceutical methods
- Abstract
In this study, we report the relationship between structure, self-assembly behavior and antimicrobial activity of multicationic gemini surfactants and their successful use as stabilizers of a new liposomal formulation for transdermal drug delivery. New surfactants containing natural moiety 1,4-diazabicyclo[2.2.2]octane with four charges and two hydrophobic chains (n-Dabco-s-Dabco-n, where s = 2, 6, 12 and n = 12, 14, 16, 18) were synthesized. A linear dependence of the CMC decrease, with the increase of the number of carbon atoms in alkyl groups (slope 0.23) was shown. The aggregation numbers of n-Dabco-2-Dabco-n are smaller than 30 and they decrease with increasing alkyl chain length. This is in compliance with the larger surface area per n-Dabco-2-Dabco-n molecule. New liposomal formulations loading Rhodamine B phosphatidylcholine (with mean size about 100 nm and increased zeta potential from -7 ± 2 mV to +55 ± 2 mV) have been successfully stabilized by n-Dabco-s-Dabco-n surfactants. These formulations were designed to improve the bioavailability and skin permeation of loaded compound. The antibacterial activity of Dabco-surfactants was shown to be strongly affected by their structure (alkyl chain length and number of charged nitrogen). 12-Dabco-2-Dabco-12 was the most active (MIC = 0.48, 0.98 and 15.6 µg/mL against S. aureus, B. cereus and E. coli, respectively) without hemolytic activity at 3.1 µg/mL concentration. PC/14-Dabco-2-Dabco-14-liposomes were shown to be the best formulation, with the highest antibacterial activity against Sa (MIC = 7.8 μg‧mL
-1 ) and lowest cytotoxicity (IC50 > 125). The modification of liposomes by Dabco-surfactants stabilizes the membrane of the vesicles, preventing the release of rhodamine B and impairing the penetration of the dye across Strat-M® membrane. Cellular uptake of rhodamine B-loaded PC/12-Dabco-2-Dabco-12-liposomes was also reported. This is the first example of cationic mixed liposomes containing Dabco-surfactants of potential interest for transdermal drug delivery., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2019 Elsevier B.V. All rights reserved.)- Published
- 2020
- Full Text
- View/download PDF
26. One-Electron Reduction of Acenaphthene-1,2-Diimine Nickel(II) Complexes.
- Author
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Khrizanforova VV, Fayzullin RR, Morozov VI, Gilmutdinov IF, Lukoyanov AN, Kataeva ON, Gerasimova TP, Katsyuba SA, Fedushkin IL, Lyssenko KA, and Budnikova YH
- Abstract
New nickel-based complexes of 1,2-bis[(2,6-diisopropylphenyl)imino]acenaphthene (dpp-bian) with BF
4 - counterion or halide co-ligands were synthesized in THF and MeCN. The nickel(I) complexes were obtained by using two approaches: 1) electrochemical reduction of the corresponding nickel(II) precursors; and 2) a chemical comproportionation reaction. The structural features and redox properties of these complexes were investigated by using single-crystal X-ray diffraction (XRD), cyclic voltammetry (CV), and electron paramagnetic resonance (EPR) and UV/Vis spectroscopy. The influence of temperature and solvent on the structure of the nickel(I) complexes was studied in detail, and an uncommon reversible solvent-induced monomer/dimer transformation was observed. In the case of the fluoride complex, the unpaired electron was found to be localized on the dpp-bian ligand, whereas all of the other nickel complexes contained neutral dpp-bian moieties., (© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)- Published
- 2019
- Full Text
- View/download PDF
27. Intriguing Near-Infrared Solid-State Luminescence of Binuclear Silver(I) Complexes Based on Pyridylphospholane Scaffolds.
- Author
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Shamsieva AV, Musina EI, Gerasimova TP, Fayzullin RR, Kolesnikov IE, Samigullina AI, Katsyuba SA, Karasik AA, and Sinyashin OG
- Abstract
A series of novel charged disilver(I) complexes with pyridyl-containing phospholanes was synthesized. These complexes were characterized using a range of spectroscopic techniques and single-crystal and powder X-ray diffraction. The complexes demonstrate solid-state near-infrared (NIR) luminescence (765-902 nm) that is unique for dinuclear Ag
I complexes. Combined spectroscopic/quantum chemical analysis suggests that the NIR luminescence of complexes 4-6 in the solid state is mainly due to crystal packing effects.- Published
- 2019
- Full Text
- View/download PDF
28. The Assembly of Unique Hexanuclear Copper(I) Complexes with Effective White Luminescence.
- Author
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Strelnik ID, Dayanova IR, Kolesnikov IE, Fayzullin RR, Litvinov IA, Samigullina AI, Gerasimova TP, Katsyuba SA, Musina EI, and Karasik AA
- Abstract
The unique L
2 Cu6 I6 complexes containing two Cu3 I3 units have been obtained via reaction of 1,5-diaza-3,7-diphosphacyclooctanes bearing ethylpyridyl substituents at phosphorus atoms with an excess of copper iodide. The structure of one of the complexes was confirmed by X-ray diffraction. It was shown that the complexes can exist in two crystalline phases with different parameters of the unit cell, which were detected by the PXRD data analyses. The solvent-free crystalline phases of the complexes display rare solid-state white emission at room temperature, which is observed due to the presence of two broad bands in the emission spectra with maxima at 464 and 610 nm. Quantum chemical computations show that the high-energy band has3 (M+X)LCT origin, whereas the low-energy band is interpreted as3 CC. The quantum yields of white luminescence of complexes reach 15-20%.- Published
- 2019
- Full Text
- View/download PDF
29. [Immunomodulating activity of adhesive dental film containing chlorhexidine and ketoprofen in serum of patients with chronic periodontitis].
- Author
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Ushakov RV, Gerasimova TP, and Nikolaev VA
- Subjects
- Chlorhexidine, Dental Cements, Humans, Luminol, Chronic Periodontitis, Ketoprofen
- Abstract
The study was carried out in series of preclinical tests of new adhesive dental film developed for local treatment of inflammatory periodontal disease and containing chlorhexidine bigluconate and ketoprofen. The aim of the work was to determine film's effect on the activity of blood neutrophils in healthy individuals and in patients with chronic periodontitis using luminol-dependent chemiluminescence method. The investigated dental film showed modulating influence on blood phagocytes methabolism depending on their initial functional state. Immunomodulating activity revealed is associated with the polymer base and is potentiated by ketoprofen in case of hyporeactive inflammation.
- Published
- 2019
- Full Text
- View/download PDF
30. The first representatives of tetranuclear gold(i) complexes of P,N-containing cyclophanes.
- Author
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Nikolaeva YA, Balueva AS, Khafizov AA, Strelnik ID, Gerasimova TP, Katsyuba SA, Litvinov IA, Musina EI, Karasik AA, and Sinyashin OG
- Abstract
The first representatives of the tetranuclear gold(i) complexes of P,N-containing cyclophanes with two 1,5-diaza-3,7-diphosphacyclooctane rings incorporated into the macrocyclic core have been obtained. The complexation leads to a change in ligand conformations so that the diazadiphosphacyclooctane fragments of the complexes adopt twist-chair conformations, and two of the four gold(i) ions are located over and under the partially collapsed macrocyclic cavity. The complexes demonstrate moderate solid-state green emission.
- Published
- 2018
- Full Text
- View/download PDF
31. [Mechanisms of tissue destruction in periodontal disease].
- Author
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Ushakov RV and Gerasimova TP
- Subjects
- Bacteria pathogenicity, Biomarkers, Chronic Periodontitis immunology, Chronic Periodontitis microbiology, Humans, Chronic Periodontitis pathology
- Published
- 2017
- Full Text
- View/download PDF
32. Synthesis of novel pyridyl containing phospholanes and their polynuclear luminescent copper(i) complexes.
- Author
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Musina EI, Shamsieva AV, Strelnik ID, Gerasimova TP, Krivolapov DB, Kolesnikov IE, Grachova EV, Tunik SP, Bannwarth C, Grimme S, Katsyuba SA, Karasik AA, and Sinyashin OG
- Abstract
A novel type of cyclic P,N-ligands, pyridyl containing phospholanes, has been synthesized in a moderate yield by the reaction of primary phosphines with 1,4-dichlorobutane in a superbasic medium. A series of homo tetranuclear octahedral Cu4I4L2, dinuclear tetrahedral Cu2I2L3, and dinuclear "head-to-tail" Cu2I2L2 luminescent complexes with these ligands were obtained. All the compounds were characterized using a range of spectroscopic and computational techniques, and in the case of some Cu4I4L2 and Cu2I2L3 complexes, by single crystal X-ray diffraction. The structural diversity of the obtained complexes was reflected in their photophysical properties: phosphorescence spectra of the compounds display emission in broad spectral range of 471-615 nm. TD-DFT computations allow the assignment of a single emission band around 550 nm for Cu2I2L3 complexes and 471 nm for Cu2I2L2 complex to a vertical triplet-singlet transition from a metal-to-ligand and halide-to-ligand charge-transfer (3)(M + X)LCT excited state, whereas a second band at around 600 nm in the spectra of octahedral Cu4I4L2 complexes was assigned predominantly to Cu4I4 cluster-centered ((3)CC) excited state.
- Published
- 2016
- Full Text
- View/download PDF
33. Synthesis and magnetic properties of manganese carbonyl complexes with different coordination modes of 3,4,5-triaryl-1,2-diphospholide ligands.
- Author
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Miluykov VA, Bezkishko IA, Kochetkova LR, Kataeva ON, Gerasimova TP, Katsyuba SA, Sinyashin OG, Lönnecke P, Hey-Hawkins E, Parameswaran A, Krupskaya Y, Kataev V, and Büchner B
- Abstract
The set of complexes bis-(μ:η(1),η(1)-3,4,5-triaryl-1,2-diphosphacyclopentadienyl)-bis-(tetracarbonyl manganese(i)) (aryl = C6H5 (), p-FC6H4 (), p-ClC6H4 ()) undergo an irreversible rearrangement to mononuclear 3,4,5-triaryl-1,2-diphosphacymantrenes (). According to quantum-chemical calculations binuclear complexes can be considered to be products of kinetic control and mononuclear species are thermodynamically favorable compounds. The antiferromagnetic intramolecular interaction observed for complexes can be effectively tuned by using substituents in the para-position of the arene ring, whereas mononuclear 1,2-diphosphacymantrenes are diamagnetic.
- Published
- 2015
- Full Text
- View/download PDF
34. Bipyridine and phenanthroline IR-spectral bands as indicators of metal spin state in hexacoordinated complexes of Fe(II), Ni(II) and Co(II).
- Author
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Gerasimova TP and Katsyuba SA
- Abstract
Possible stable structures of various 2,2'-bipyridine (bpy) and 1,10-phenanthroline (phen) complexes, [Ni(bpy)(3)](2+), [Co(bpy)(3)](2+), [Fe(bpy)(3)](2+) and Fe(phen)(2)(NCS)(2), were optimized for different spin states of the metals, and the spectra computed for every form were compared with the experimental IR spectra of the compounds. It is demonstrated that the changes in spin states of the metals influence both geometry and vibrational spectra of the complexes. Spectral changes are predicted not only in the low frequency range, corresponding to metal-ligand vibrations, but also in the mid-IR range, where ligand vibrations are active. Detailed computational analysis in combination with the corresponding spectroscopic experiment shows that the spectral changes are of a similar character for complexes with the same ligands independent on the central metal and can be used as spectroscopic markers of the electronic state of the latter. Found spectral markers have been validated at a number of complexes of Fe(II), Ni(II), Co(II), Zn(II) and Cu(II) with bpy and phen ligands.
- Published
- 2013
- Full Text
- View/download PDF
35. [Effect of statins on activity of matrix metalloproteases and serum concentration of cystatin C in patients with various risk of development of ischemic heart disease and in patients after coronary artery bypass surgery].
- Author
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Cherkanova MS, Korolenko TA, Bravve IIu, and Gerasimova TP
- Subjects
- Adult, Biomarkers, C-Reactive Protein metabolism, Coronary Vessels metabolism, Coronary Vessels physiopathology, Female, Humans, Inflammation drug therapy, Inflammation metabolism, Male, Middle Aged, Myocardial Ischemia physiopathology, Myocardial Ischemia therapy, Plaque, Atherosclerotic drug therapy, Plaque, Atherosclerotic etiology, Plaque, Atherosclerotic metabolism, Risk Assessment methods, Coronary Artery Bypass methods, Cystatin C blood, Hexosaminidases metabolism, Hydroxymethylglutaryl-CoA Reductase Inhibitors administration & dosage, Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects, Hydroxymethylglutaryl-CoA Reductase Inhibitors metabolism, Metalloproteases metabolism, Myocardial Ischemia metabolism
- Abstract
We compared new non-lipid atherosclerosis indexes related to inflammation and macrophage stimulation (serum concentration of cystatin C, matrix metalloproteases and chitotriosidase activity) with common inflammatory (high sensitivity C reactive protein) and lipid markers in elderly persons and patients with atherosclerosis and ischemic heart disease who have undergone coronary bypass surgery.
- Published
- 2012
36. [The activity of metalloproteinases and concentration of C-reactive protein in the blood of patients with coronary heart disease during the administration of statins and coronary artery bypass surgery].
- Author
-
Cherkanova MS, Korolenko TA, Bravve IIu, and Gerasimova TP
- Subjects
- Adult, Aged, Biomarkers blood, Case-Control Studies, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors administration & dosage, Metalloproteases blood, Middle Aged, Myocardial Ischemia drug therapy, Myocardial Ischemia enzymology, Myocardial Ischemia surgery, Young Adult, Aging blood, C-Reactive Protein analysis, Coronary Artery Bypass, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Metalloproteases metabolism, Myocardial Ischemia blood
- Published
- 2009
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