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1. Association of Renin Angiotensin Aldosterone System Inhibitors and Outcomes of Hospitalized Patients With COVID-19

Author

Gupta, Neha, Settle, Lisa, Brown, Brent R, Armaignac, Donna L, Baram, Michael, Perkins, Nicholas E, Kaufman, Margit, Melamed, Roman R, Christie, Amy B, Danesh, Valerie C, Denson, Joshua L, Cheruku, Sreekanth R, Boman, Karen, Bansal, Vikas, Kumar, Vishakha K, Walkey, Allan J, Domecq, Juan P, Kashyap, Rahul, Aston, Christopher E, Mesland, Jean-Baptiste, Henin, Pierre, Petre, Hélène, Buelens, Isabelle, Gerard, Anne-Catherine, Clevenbergh, Philippe, Granado, Rolando Claure-Del, Mercado, Jose A, Vega-Terrazas, Esdenka, Iturricha-Caceres, Maria F, Garza, Ruben, Chu, Eric, Chan, Victoria, Gavidia, Oscar Y, Pachon, Felipe, Sanchez, Yeimy A, knežević, Danijel, Kassas, Mohamed El, Badr, Mohamed, Tawheed, Ahmed, Yahia, Hend, Kantas, Dimitrios, Koulouras, Vasileios, Pineda, Estela, Guillen, Gabina María Reyes, Soto, Helin Archaga, Lizardo, Ana Karen Vallecillo, Kopitkó, Csaba, Bencze, Ágnes, Méhész, István, Gerendai, Zsófia, Doddaga, Phaneendra, Chandra, Neethi, Segu, Smitha S, Chakraborty, Tuhin, Joyce, Epcebha, Vadgaonkar, Girish, Ediga, Rekha, Basety, Shilpa, Dammareddy, Shwetha, Kasumalla, Phani Sreeharsha, Raju, Umamaheswara, Manduva, Janaki, Kolakani, Naresh, Sripathi, Shreeja, Chaitanya, Sheetal, Cherian, Anusha, Parameswaran, Sreejith, Parthiban, Magesh, A., Menu Priya, Prabhu, Madhav, Jakati, Vishal, Rijhwani, Puneet, Jain, Ashish, Gupta, Aviral, Jaiswal, Ram Mohan, Tyagi, Ambika, Mathur, Nimish, Daga, Mradul Kumar, Agarwal, Munisha, Rohtagi, Ishan, Papani, Sridhar, Kamuram, Mahesh, Agrawal, Kamlesh Kumar, Baghel, Vijendra, Patel, Kirti Kumar, Mohan, Surapaneni Krishna, Jyothisree, Ekambaram, Petrolwala, Mukur, Ladva, Bharat, Dalili, Nooshin, Nafa, Mohsen, Matsuda, Wataru, Suzuki, Reina, Tahara, Shu, Sanui, Masamitsu, Horikita, Sho, Itagaki, Yuki, and Kodate, Akira

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Coronaviruses, Emerging Infectious Diseases, Infectious Diseases, Good Health and Well Being, Adult, Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Humans, Hypertension, Male, Middle Aged, Renin-Angiotensin System, Retrospective Studies, COVID-19 Drug Treatment, Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group, Nursing, Public Health and Health Services, Emergency & Critical Care Medicine, Clinical sciences
Abstract

ObjectivesTo determine the association of prior use of renin-angiotensin-aldosterone system inhibitors (RAASIs) with mortality and outcomes in hospitalized patients with COVID-19.DesignRetrospective observational study.SettingMulticenter, international COVID-19 registry.SubjectsAdult hospitalized COVID-19 patients on antihypertensive agents (AHAs) prior to admission, admitted from March 31, 2020, to March 10, 2021.InterventionsNone.Measurements and main resultsData were compared between three groups: patients on RAASIs only, other AHAs only, and those on both medications. Multivariable logistic and linear regressions were performed after controlling for prehospitalization characteristics to estimate the effect of RAASIs on mortality and other outcomes during hospitalization. Of 26,652 patients, 7,975 patients were on AHAs prior to hospitalization. Of these, 1,542 patients (19.3%) were on RAASIs only, 3,765 patients (47.2%) were on other AHAs only, and 2,668 (33.5%) patients were on both medications. Compared with those taking other AHAs only, patients on RAASIs only were younger (mean age 63.3 vs 66.9 yr; p < 0.0001), more often male (58.2% vs 52.4%; p = 0.0001) and more often White (55.1% vs 47.2%; p < 0.0001). After adjusting for age, gender, race, location, and comorbidities, patients on combination of RAASIs and other AHAs had higher in-hospital mortality than those on RAASIs only (odds ratio [OR] = 1.28; 95% CI [1.19-1.38]; p < 0.0001) and higher mortality than those on other AHAs only (OR = 1.09; 95% CI [1.03-1.15]; p = 0.0017). Patients on RAASIs only had lower mortality than those on other AHAs only (OR = 0.87; 95% CI [0.81-0.94]; p = 0.0003). Patients on ACEIs only had higher mortality compared with those on ARBs only (OR = 1.37; 95% CI [1.20-1.56]; p < 0.0001).ConclusionsAmong patients hospitalized for COVID-19 who were taking AHAs, prior use of a combination of RAASIs and other AHAs was associated with higher in-hospital mortality than the use of RAASIs alone. When compared with ARBs, ACEIs were associated with significantly higher mortality in hospitalized COVID-19 patients.

Published
2022

2. Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study

Author

Elshorbagy, Amany, Lyons, Alexander R.M., Vallejo-Vaz, Antonio J., Stevens, Christophe A.T., Dharmayat, Kanika I., Brandts, Julia, Catapano, Alberico L., Freiberger, Tomas, Hovingh, G. Kees, Mata, Pedro, Raal, Frederick J., Santos, Raul D., Soran, Handrean, Watts, Gerald F., Abifadel, Marianne, Aguilar-Salinas, Carlos A., Alhabib, Khalid F., Alkhnifsawi, Mutaz, Almahmeed, Wael, Alonso, Rodrigo, Al-Rasadi, Khalid, Al-Sarraf, Ahmad, Ashavaid, Tester F., Banach, Maciej, Binder, Christoph J., Bourbon, Mafalda, Brunham, Liam R., Chlebus, Krzysztof, Corral, Pablo, Cruz, Diogo, Davletov, Kairat, Descamps, Olivier S., Ezhov, Marat, Gaita, Dan, Groselj, Urh, Harada-Shiba, Mariko, Holven, Kirsten B., Kayikcioglu, Meral, Khovidhunkit, Weerapan, Lalic, Katarina, Latkovskis, Gustavs, Laufs, Ulrich, Liberopoulos, Evangelos, Lima-Martinez, Marcos M., Lin, Jie, Maher, Vincent, Marais, A. David, März, Winfried, Mirrakhimov, Erkin, Miserez, André R., Mitchenko, Olena, Nawawi, Hapizah, Nordestgaard, Børge G., Panayiotou, Andrie G., Paragh, György, Petrulioniene, Zaneta, Pojskic, Belma, Postadzhiyan, Arman, Reda, Ashraf, Reiner, Željko, Reyes, Ximena, Sadiq, Fouzia, Sadoh, Wilson E., Schunkert, Heribert, Shek, Aleksandr B., Stroes, Erik, Su, Ta-Chen, Subramaniam, Tavintharan, Susekov, Andrey V., Tilney, Myra, Tomlinson, Brian, Truong, Thanh-Huong, Tselepis, Alexandros D., Tybjærg-Hansen, Anne, Vázquez, Alejandra C., Viigimaa, Margus, Vohnout, Branislav, Wang, Luya, Yamashita, Shizuya, Arca, Marcello, Averna, Maurizio, Schreier, Laura, Pang, Jing, Ebenbichler, Christoph, Dieplinger, Hans, Innerhofer, Reinhold, Winhofer-Stöckl, Yvonne, Greber-Platzer, Susanne, Krychtiuk, Konstantin, Speidl, Walter, Toplak, Hermann, Widhalm, Kurt, Stulnig, Thomas, Huber, Kurt, Höllerl, Florian, Rega-Kaun, Gersina, Kleemann, Lucas, Mäser, Martin, Scholl-Bürgi, Sabine, Säly, Christoph, Mayer, Florian J., Sperone, Alexandra, Tanghe, Chloé, Gérard, Anne-Catherine, Pojskic, Lamija, Sisic, Ibrahim, Durak Nalbantic, Azra, Ejubovic, Malik, Jannes, Cinthia E., Pereira, Alexandre C., Krieger, Jose E., Petrov, Ivo, Goudev, Assen, Nikolov, Fedya, Tisheva, Snejana, Yotov, Yoto, Tzvetkov, Ivajlo, Baass, Alexis, Bergeron, Jean, Bernard, Sophie, Brisson, Diane, Cermakova, Lubomira, Couture, Patrick, Francis, Gordon A., Gaudet, Daniel, Hegele, Robert A., Khoury, Etienne, Mancini, G.B. John, McCrindle, Brian W., Paquette, Martine, Ruel, Isabelle, Iatan, Iulia, Cuevas, Ada, Wang, Xumin, Meng, Kang, Song, Xiantao, Yong, Qiang, Jiang, Tao, Liu, Ziyou, Duan, Yanyu, Hong, Jing, Ye, Pucong, Chen, Yan, Qi, Jianguang, Liu, Zesen, Li, Yuntao, Zhang, Chaoyi, Peng, Jie, Yang, Ya, Yu, Wei, Wang, Qian, Yuan, Hui, Cheng, Shitong, Jiang, Long, Chong, Mei, Jiao, Jian, Wu, Yue, Wen, Wenhui, Xu, Liyuan, Zhang, Ruiying, Qu, Yichen, He, Jianxun, Fan, Xuesong, Wang, Zhenjia, Chow, Elaine, Pećin, Ivan, Perica, Dražen, Symeonides, Phivos, Vrablik, Michal, Ceska, Richard, Soska, Vladimir, Tichy, Lukas, Adamkova, Vera, Franekova, Jana, Cifkova, Renata, Kraml, Pavel, Vonaskova, Katerina, Cepova, Jana, Dusejovska, Magdalena, Pavlickova, Lenka, Blaha, Vladimir, Rosolova, Hana, Nussbaumerova, Barbora, Cibulka, Roman, Vaverkova, Helena, Cibickova, Lubica, Krejsova, Zdenka, Rehouskova, Katerina, Malina, Pavel, Budikova, Milena, Palanova, Vaclava, Solcova, Lucie, Lubasova, Alena, Podzimkova, Helena, Bujdak, Juraj, Vesely, Jiri, Jordanova, Marta, Salek, Tomas, Urbanek, Robin, Zemek, Stanislav, Lacko, Jan, Halamkova, Hana, Machacova, Sona, Mala, Sarka, Cubova, Eva, Valoskova, Katerina, Burda, Lukas, Benn, Marianne, Bendary, Ahmed, Daoud, Ihab, Emil, Sameh, Elbahry, Atef, Rafla, Samir, Sanad, Osama, Kazamel, Ghada, Ashraf, Dr Mohamed, Sobhy, Mohamed, El-Hadidy, Amro, Shafy, Mohamed Abdoul, Kamal, Saif, Bendary, Mohamed, Talviste, Grete, Christmann, Jutta, Dressel, Alexander, Fath, Felix, Ferraro, Chiara, Frenzke, Lydia, Gopon, Alica, Klein, Isabel, Pienkowska, Dominika, Sietmann, Tobias, Sonntag, Antonia, Adjan, Omar, Bahrmann, Philipp, Baessler, Andrea, Barkowski, Rasmus, Beckerdjian, Raffi, Berr, Christina, Birkenfeld, Andreas, Böll, Gereon, Carstensen, Avisha, Demuth, Ilya, Finkernagel, Holger, Gouni-Berthold, Ioanna, Hahmann, Harry, Hamerle, Michael, Halder, Julian, Heide, Maria, Julius, Ulrich, Kassner, Ursula, Katzmann, Julius L, Kirschbaum, Anja, Klose, Gerald, Könemann, Stephanie, König, Christel, König, Wolfgang, Krämer, Bernhard, Kuprat, Gerrit, Koschker, Ann-Cathrin, Kilic, Özlem, Lindenmeier, Gerd, Van de Loo, Iris, Lorenz, Babette, Lorenz, Elke, Löhr, Birgit, McChord, Johanna, Maslarska, Mariya, Methe, Heiko, Merkel, Martin, Moussaoui, Zineb, Müller-Kozarez, Irina, Olivier, Christoph B, Ong, Peter, Otte, Britta, Parhofer, Klaus, Partsch, Carl-Joachim, Paulus, Michael, Pehlivanli, Sinan, Pflederer, Tobias, Pusl, Thomas, Richter, Veronika, Rosner, Stefanie, Sanin, Veronika, Schäfer, Sebastian, Schäfer, Christoph, Schatz, Ulrike, Schirmer, Stephan, Schmidt, Christine, Seeger, Wolfgang, Sisovic, Snezna, Spens, Antje, Jablonski, Ksenija Stach, Stadelmann, Alexander, Steinhagen-Thiessen, Elisabeth, Stürzebecher, Paulina, Tafelmeier, Maria, Tillack, Dörthe, Tselmin, Sergey, Tünnemann-Tarr, Adrienn, Vogt, Anja, Beckerath, Jens von, Wilke, Andreas, Wolf, Ulrich, Zemmrich, Claudia, Rizos, Christos V., Skoumas, Ioannis, Tziomalos, Konstantinos, Rallidis, Loukianos, Kotsis, Vasileios, Doumas, Michalis, Athyros, Vasileios, Skalidis, Emmanouil, Kolovou, Genovefa, Kolovou, Vana, Garoufi, Anastasia, Bilianou, Eleni, Koutagiar, Iosif, Kiouri, Estela, Antza, Christina, Zacharis, Evangelos, Attilakos, Achilleas, Sfikas, George, Koumaras, Charalambos, Anagnostis, Panagiotis, Anastasiou, Georgia, Liamis, George, Koutsogianni, Amalia-Despoina, Petkou, Ermioni, Milionis, Haralambos, Koulouri, Anastasia, Prodromiadou, Elisavet, Karányi, Zsolt, Harangi, Mariann, Bajnok, László, Audikovszky, Mária, Márk, László, Benczúr, Béla, Reiber, István, Nagy, Gergely, Nagy, András, Reddy, Lakshmi Lavanya, Shah, Swarup A. V, Ponde, Chandrashekhar K., Dalal, Jamshed J., Sawhney, Jitendra P.S., Verma, Ishwar C., Altaey, Mays, Al-Jumaily, Khalid, Rasul, Dilshad, Abdalsahib, Ali Fawzi, Jabbar, Amer Abdl, Al-ageedi, Mohanad, Dhamin, Mohammed, AlFil, Sarmad, Khadhim, Foad, Miahy, Sabah, Agar, Ruth, Catapano, Alberico Luigi, Calandra, Sebastiano, Tarugi, Patrizia, Casula, Manuela, Galimberti, Federica, Olmastroni, Elena, Sarzani, Riccardo, Ferri, Claudio, Repetti, Elena, Piro, Salvatore, Suppressa, Patrizia, Meregalli, Giancarla, Borghi, Claudio, Muntoni, Sandro, Calabrò, Paolo, Cipollone, Francesco, Purrello, Francesco, Pujia, Arturo, Passaro, Angelina, Marcucci, Rossella, Pecchioli, Valerio, Pisciotta, Livia, Mandraffino, Giuseppe, Pellegatta, Fabio, Mombelli, Giuliana, Branchi, Adriana, Fiorenza, Anna Maria, Pederiva, Cristina, Werba, Josè Pablo, Parati, Gianfranco, Carubbi, Francesca, Iughetti, Lorenzo, Fortunato, Giuliana, Iannuzzi, Arcangelo, Iannuzzo, Gabriella, Cefalù, Angelo Baldassare, Biasucci, Giacomo, Zambon, Sabina, Pirro, Matteo, Sbrana, Francesco, Trenti, Chiara, D'Erasmo, Laura, Federici, Massimo, Ben, Maria Del, Bartuli, Andrea, Giaccari, Andrea, Pipolo, Antonio, Citroni, Nadia, Guardamagna, Ornella, Lia, Salvatore, Benso, Andrea, Biolo, Gianni, Maroni, Lorenzo, Lupi, Alessandro, Bonanni, Luca, Rinaldi, Elisabetta, Zenti, Maria Grazia, Matsuki, Kota, Hori, Mika, Ogura, Masatsune, Masuda, Daisaku, Kobayashi, Takuya, Nagahama, Kumiko, Al-Jarallah, Mohammed, Radovic, Mirjana, Lunegova, Olga, Bektasheva, Erkayim, Abilova, Saamay, Erglis, Andrejs, Gilis, Dainus, Nesterovics, Georgijs, Saripo, Vita, Meiere, Ruta, Skudrina, Gunda, Terauda, Elizabete, Jambart, Selim, Ayoub, Carine, Ghaleb, Youmna, Aliosaitiene, Urte, Kutkiene, Sandra, Abdul Kadir, Siti Hamimah Sheikh, Kasim, Noor Alicezah Mohd, Nor, Noor Shafina Mohd, Abdul Hamid, Hasidah, Abdul Razak, Suraya, Al-Khateeb, Alyaa, Abd Muid, Suhaila, Abdul Rahman, Thuhairah, Kasim, Sazzli Shahlan, Radzi, Ahmad Bakhtiar Md, Ibrahim, Khairul Shafiq, Rosli, Marshima Mohd, Razali, Rafezah, Chua, Yung An, Razman, Aimi Zafira, Nazli, Sukma Azureen, Aziz, Nazirul, Rosman, Azhari, Abdul Murad, NorAzian, Jalaludin, Mohd Amin, Abdul Latif, Ahmad Zubaidi, Azzopardi, C., Mehta, Roopa, Martagon, Alexandro J., Ramirez, Gabriela A. Galan, Villa, Neftali E Antonio, Vazquez, Arsenio Vargas, Elias-Lopez, Daniel, Retana, Gustavo Gonzalez, Rodriguez, Betsabel, Macías, Jose J. Ceballos, Zazueta, Alejandro Romero, Alvarado, Rocio Martinez, Portano, Julieta D. Morales, Lopez, Humberto Alvares, Sauque-Reyna, Leobardo, Herrera, Laura G. Gomez, Mendia, Luis E. Simental, Aguilar, Humberto Garcia, Cooremans, Elizabeth Ramirez, Aparicio, Berenice Peña, Zubieta, Victoria Mendoza, Gonzalez, Perla A. Carrillo, Ferreira-Hermosillo, Aldo, Portilla, Nacu Caracas, Dominguez, Guadalupe Jimenez, Garcia, Alinna Y. Ruiz, Cazares, Hector E. Arriaga, Gonzalez, Jesus R., Valencia, Carla V. Mendez, Padilla, Francisco G., Prado, Ramon Madriz, Ibarra, Manuel O. De los Rios, Villicaña, Ruy D. Arjona, Rivera, Karina J. Acevedo, Carrera, Ricardo Allende, Alvarez, Jose A., Martinez, Jose C. Amezcua, Bustillo, Manuel de los Reyes Barrera, Vargas, Gonzalo Carazo, Chacon, Roberto Contreras, Andrade, Mario H. Figueroa, Ortega, Ashanty Flores, Alcala, Hector Garcia, de Leon, Laura E. Garcia, Guzman, Berenice Garcia, Garcia, Jose J. Garduño, Cuellar, Juan C. Garnica, Cruz, Jose R. Gomez, Garcia, Anell Hernandez, Almada, Jesus R. Holguin, Herrera, Ursulo Juarez, Sobrevilla, Fabiola Lugo, Rodriguez, Eduardo Marquez, Sibaja, Cristina Martinez, Rodriguez, Alma B. Medrano, Oyervides, Jose C. Morales, Vazquez, Daniel I. Perez, Rodriguez, Eduardo A. Reyes, Osorio, Ma. Ludivina Robles, Saucedo, Juan Rosas, Tamayo, Margarita Torres, Talavera, Luis A. Valdez, Arroyo, Luis E. Vera, Carrillo, Eloy A. Zepeda, Stroes, Erik S, Defesche, J, Zuurbier, L, Reeskamp, L, Ibrahim, S, Roeters van Lennep, Jeanine, Wiegman, Albert, Isara, Alphonsus, Obaseki, Darlington E., Al-Waili, Khalid, Al-Zadjali, Fahad, Al-Zakwani, Ibrahim, Al-Kindi, Mohammed, Al-Mukhaini, Suad, Al-Barwani, Hamida, Rana, Asim, Shah, Lahore Saeed Ullah, Al-Nouri, Fahad, Starostecka, Ewa, Konopka, Agnieszka, Bielecka-Dabrowa, Agata, Lewek, Joanna, Sosnowska, Bozena, Gąsior, Mariusz, Dyrbuś, Krzysztof, Jóźwiak, Jacek, Pajkowski, Marcin, Romanowska-Kocejko, Marzena, Żarczyńska-Buchowiecka, Marta, Chmara, Magdalena, Wasąg, Bartosz, Stróżyk, Aneta, Michalska-Grzonkowska, Aleksandra, Medeiros, Ana Margarida, Alves, Ana Catarina, Silva, Francisco, Lobarinhas, Goreti, Palma, Isabel, de Moura, Jose Pereira, Rico, Miguel Toscano, Rato, Quitéria, Pais, Patrícia, Correia, Susana, Moldovan, Oana, Virtuoso, Maria João, Araujo, Francisco, Salgado, Jose Miguel, Colaço, Ines, Dumitrescu, Andreea, Lengher, Calin, Mosteoru, Svetlana, Meshkov, Alexey, Ershova, Alexandra, Rozhkova, Tatiana, Korneva, Victoria, Yu, Kuznetsova T., Zafiraki, Vitaliy, Voevoda, Mikhail, Gurevich, Victor, Duplyakov, Dmitry, Ragino, Yulia, Chubykina, Uliana, Shaposhnik, Igor, Alkaf, Fahmi, Khudari, Alia, Rwaili, Nawal, Al-Allaf, Faisal, Alghamdi, Mohammad, Batais, Mohammed A, Almigbal, Turky H, Kinsara, Abdulhalim, AlQudaimi, Ashraf Hammouda Ahmed, Awan, Zuhier, Elamin, Omer A, Altaradi, Hani, Popovic, Ljiljana, Singh, Sandra, Rasulic, Iva, Petakov, Ana, Lalic, Nebojsa M., Lam, Carolyn, Le, Tan Ju, Siang, Eric Lim Tien, Dissanayake, Sanjaya, I-Shing, Justin Tang, Shyong, Tai E, Jin, Terrance Chua Siang, Ting, Sharon Pek Li, Ming, Jeremy Hoe Kian, Drum, Chester Lee, Nastar, Fathima Ashna, Jia, Loh Wann, Ya, Natalie Koh Si, Jie, Marvin Chua Wei, Dalan, Rinkoo, Wei, Yong Quek, sian, Tiong Yee, Keong, Yeo Khung, Rong, Siau Kai, Jin, Darren Seah Ee, Ming, Ian Koh Jan, Chang, Tan Hong, Peng, Fabian Yap Kok, Vasanwala, Rashida Farhad, Raslova, Katarina, Balinth, Karin, Buganova, Ingrid, Fabryova, Lubomira, Kadurova, Michaela, Klabnik, Alexander, Kozárová, Miriam, Sirotiakova, Jana, Battelino, Tadej, Cevc, Matija, Debeljak, Marusa, Torkar, Ana Drole, Fras, Zlatko, Jug, Borut, Cugalj, Barbara Kern, Kovac, Jernej, Mlinaric, Matej, Sikonja, Jaka, Pilcher, Gillian Joan, Blom, D J, Wolmarans, K H, Brice, B C, Muñiz-Grijalvo, Ovidio, Díaz-Díaz, Jose Luis, de Isla, Leopoldo Pérez, Fuentes, Francisco, Badimon, Lina, Martin, François, Miserez, Eleonore B., Shipton, Janine L., Ganokroj, Poranee, Chattranukulchai, Pairoj, Jiamjarasrungsi, Wiroj, Thongtang, Nuntakorn, Krittayaphong, Rungroj, Vathesatogkit, Prin, Sriphrapradang, Chutintorn, Phimphilai, Mattabhorn, Leelawattana, Rattana, Anthanont, Pimjai, Suraamornkul, Swangjit, Deerochanawong, Chaicharn, Senthong, Vichai, Torpongpun, Artit, Suteerayongprasert, Panuwat, Pengpong, Nawarat, Sathavarodom, Nattapol, Sunanta, Usanee, Porntharukchareon, Thachanun, Kiatpanabhikul, Phatharaporn, Kaewkrasaesin, Chatchon, Kongkit, Jaruwan, Umphonsathien, Mongkontida, Akbulut, Mehmet, Alici, Gökhan, Bayram, Fahri, Can, Levent Hürkan, Celik, Ahmet, Ceyhan, Ceyhun, Coskun, Fatma Yilmaz, Demir, Mesut, Demircan, Sabri, Dogan, Volkan, Durakoglugil, Emre, Dural, İbrahim Etem, Gedikli, Omer, Hacioglu, Aysa, Ildizli, Muge, Kilic, Salih, Kirilmaz, Bahadir, Kutlu, Merih, Oguz, Aytekin, Ozdogan, Oner, Onrat, Ersel, Ozer, Savas, Sabuncu, Tevfik, Sahin, Tayfun, Sivri, Fatih, Sonmez, Alper, Temizhan, Ahmet, Topcu, Selim, Tokgozoglu, Lale, Tuncez, Abdullah, Vural, Mirac, Yenercag, Mustafa, Yesilbursa, Dilek, Yigit, Zerrin, Yildirim, Aytul Belgi, Yildirir, Aylin, Yilmaz, Mehmet Birhan, Atallah, Bassam, Traina, Mahmoud, Sabbour, Hani, Abdul Hay, Dana, Luqman, Neama, Elfatih, Abubaker, Abdulrasheed, Arshad, Manla, Yosef, Kwok, See, DellOca, Nicolas, Alieva, Rano B., Fozilov, Khurshid G., Hoshimov, Shavkat U., Nizamov, Ulugbek I., Kan, Liliya E., Kim, Andrey R., Abdullaeva, Guzal J., Abdullaev, Alisher A., Do, Doan Loi, Nguyen, Mai Ngoc Thi, Kim, Ngoc Thanh, Le, Thanh Tung, Le, Hong An, and Ray, Kausik K.

Published
2024
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3. Variation in Sedative and Analgesic Use During the COVID-19 Pandemic and Associated Outcomes

Author

Mesland, Jean-Baptiste, Henin, Pierre, Petre, Hélène, Buelens, Isabelle, Gerard, Anne-Catherine, Markotić, Dragana, Bošnjak, Ivana, Garza, Ruben, Chu, Eric, Chan, Victoria, Gavidia, Oscar Y., Pachon, Felipe, El Kassas, Mohamed, Tawheed, Ahmed, Matsuda, Wataru, Itagaki, Yuki, Kodate, Akira, Suzuki, Reina, Takahashi, Yuki, Moriki, Koyo, Amer, Marwa Ridha, Bawazeer, Mohammed Abdullah, Dahhan, Talal I., Kseibi, Eiad, Butt, Abid Shahzad, Khurshid, Syed Moazzum, Rabee, Muath, Abujazar, Mohammed, Alghunaim, Razan, Abualkhair, Maal, AlFirm, Abeer Turki, Almazyad, Mohammed A., Alarifi, Mohammed I., Macarambon, Jara M., Bukhari, Ahmad Abdullah, Albahrani, Hussain A., Asfina, Kazi N., Aldossary, Kaltham M., Bojicic, Jovana, Kovacevic, Bojan, Predrag, Stevanovic, Stojakov, Dejan S., Ignjatovic, Duska K., Bojic, Suzana C., Bobos, Marina M., Nenadic, Irina B., Zaric, Milica S., Djuric, Marko D., Djukic, Vladimir R., Teruel, Santiago Y., Martin, Belen C., Kharbanda, Anmol, Jhajhria, Sunil, Fyffe, Zachary, Capizzi, Stephen, Alicie, Bethany, Green, Martha, Crockarell, Lori, Drennan, Amelia, Dubuque, Kathleen, Fambrough, Tonya, Gasaway, Nikole, Krantz, Briana, Nebi, Peiman, Orga, Jan, Serfass, Margaret, Simion, Alina, Warren, Kimberly, Wheeler, Cassie, Woolman, C.J., Christie, Amy B., Ashley, Dennis W., Adiga, Rajani, Newsome, Andrea Sikora, Forehand, Christy C., Bruning, Rebecca, Jones, Timothy W., Walkey, Allan J., Waikar, Sushrut S., Garcia, Michael A., Colona, Mia, Kibbelaar, Zoe, Leong, Michael, Wallman, Daniel, Soni, Kanupriya, Maccarone, Jennifer, Gilman, Joshua, Devis, Ycar, Chung, Joseph, Paracha, Munizay, Lumelsky, David N., DiLorenzo, Madeline, Abdurrahman, Najla, Johnson, Shelsey, Tirupathi, Raghavendra, Tang, Alymer, Safi, Arshad, Green, Cindy, Newell, Jackie, Ramani, Naga, Ganti, Bhavani Harika, Daugherty, Steven K., Atkinson, Sam, Shrimpton, Kelly, Smalls, Norma, Reilkoff, Ronald A., Heneghan, Julia A., Eichen, Sarah, Goertzen, Lexie, Rajala, Scott, Feussom, Ghislaine, Tang, Ben, Cartin-Ceba, Rodrigo, Sen, Ayan, Talaei, Fahimeh, Kashyap, Rahul, Domecq, Juan Pablo, Gajic, Ognjen, Bansal, Vikas, Tekin, Aysun, Lal, Amos, O'Horo, John C., Deo, Neha N., Sharma, Mayank, Qamar, Shahraz, Singh, Romil, Valencia Morales, Diana J., Sharma, Nikhil, Khan, Syed Anjum, Jain, Nitesh Kumar, Koritala, Thoyaja, Khedr, Anwar M., Mushtaq, Hisham A., Jama, Abbas B., Venkata, Chakradhar, Engemann, Miriam, Mantese, Annamarie, Aulakh, Bhagat S., Tripathi, Sandeep, Bandy, Jennifer A., Kreps, Lisa M., Bollinger, Dawn R., Stienecker, Roger Scott, Melendez, Andre G., Brunner, Tressa A., Budzon, Sue M., Heffernan, Jessica L., Souder, Janelle M., Miller, Tracy L., Maisonneuve, Andrea G., Vilella, Antonia L., Kutner, Sara B., Clark, Kacie, Moore, Danielle, Zaren, Howard A., Smith, Stephanie J., Lewis, Grant C., Seames, Lauren, Farlow, Cheryl, Miller, Judy, Broadstreet, Gloria, Martinez, Anthony, Allison, Micheal, Mittal, Aniket, Ruiz, Rafael, Skaanland, Aleta, Ross, Robert, Bernstein, Michael A., Goff, Ian K., Naftilan, Matthew, Mathew, Amal, Williams, Deborah, Murdock, Sue, Ducey, Maryanne, Nelson, Kerianne, Gupta, Neha, Jones, Tracy L., Ayers, Shonda C., Harrell, Amy B., Brown, Brent R., Malone, Kassidy, Sinko, Lauren A., Settle, Lisa M., Sears, Taylor J., McGonagill, Patrick W., Galet, Colette, Hubbard, Janice, Wang, David, Allan, Lauren, Badheka, Aditya, Chegondi, Madhuradhar, Stapleton, Renee D., Dixon, Anne E., Johnson, Olivia, Ardren, Sara S., Burns, Stephanie, Raymond, Anna, Gonyaw, Erika, Hodgdon, Kevin, Housenger, Chloe, Lin, Benjamin, McQuesten, Karen, Pecott-Grimm, Heidi, Sweet, Julie, Ventrone, Sebastian, Khanna, Ashish K., Harris, Lynnette, Cusson, Bruce, Reeves, Brandon, Fanelli, Jessica, Disher, Nataya, Samant, Anusha, DeGroot, Chritian, Youshock, Evan, Ligon, R. Miller, McCartney, Katherine, Garcia, Julio, Iloabachie, Chidi, Flores, Kelsey, VanEenenaam, David, Sands, Lauren, Robinson, Samuel, Sweatt, Nia, Fowler, Jacob, Fram, Madeline, Howard, Easton, Johnson, Kathleen, Udoh, Imoh, Nosow, Lillian, Howard, Lucy Winesett, Minh Pham, Quan Duc, Irfanullah, Aman, Ong, Tiffany, Enwezor, Chukwunyelu Henry, Dabagian, Hannah, Mendoza, Rafael, Rucci, Justin M., Law, Anica C., Bolesta, Scott, Quinn, Emily K., Boman, Karen, Yus, Santiago, Goodspeed, Valerie M., and Kumar, Vishakha

Published
2024
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4. Variation in Sedative and Analgesic Use During the COVID-19 Pandemic and Associated Outcomes

Author

Rucci, Justin M., primary, Law, Anica C., additional, Bolesta, Scott, additional, Quinn, Emily K., additional, Garcia, Michael A., additional, Gajic, Ognjen, additional, Boman, Karen, additional, Yus, Santiago, additional, Goodspeed, Valerie M., additional, Kumar, Vishakha, additional, Kashyap, Rahul, additional, Walkey, Allan J., additional, Mesland, Jean-Baptiste, additional, Henin, Pierre, additional, Petre, Hélène, additional, Buelens, Isabelle, additional, Gerard, Anne-Catherine, additional, Markotić, Dragana, additional, Bošnjak, Ivana, additional, Garza, Ruben, additional, Chu, Eric, additional, Chan, Victoria, additional, Gavidia, Oscar Y., additional, Pachon, Felipe, additional, El Kassas, Mohamed, additional, Tawheed, Ahmed, additional, Matsuda, Wataru, additional, Itagaki, Yuki, additional, Kodate, Akira, additional, Suzuki, Reina, additional, Takahashi, Yuki, additional, Moriki, Koyo, additional, Amer, Marwa Ridha, additional, Bawazeer, Mohammed Abdullah, additional, Dahhan, Talal I., additional, Kseibi, Eiad, additional, Butt, Abid Shahzad, additional, Khurshid, Syed Moazzum, additional, Rabee, Muath, additional, Abujazar, Mohammed, additional, Alghunaim, Razan, additional, Abualkhair, Maal, additional, AlFirm, Abeer Turki, additional, Almazyad, Mohammed A., additional, Alarifi, Mohammed I., additional, Macarambon, Jara M., additional, Bukhari, Ahmad Abdullah, additional, Albahrani, Hussain A., additional, Asfina, Kazi N., additional, Aldossary, Kaltham M., additional, Bojicic, Jovana, additional, Kovacevic, Bojan, additional, Predrag, Stevanovic, additional, Stojakov, Dejan S., additional, Ignjatovic, Duska K., additional, Bojic, Suzana C., additional, Bobos, Marina M., additional, Nenadic, Irina B., additional, Zaric, Milica S., additional, Djuric, Marko D., additional, Djukic, Vladimir R., additional, Teruel, Santiago Y., additional, Martin, Belen C., additional, Kharbanda, Anmol, additional, Jhajhria, Sunil, additional, Fyffe, Zachary, additional, Capizzi, Stephen, additional, Alicie, Bethany, additional, Green, Martha, additional, Crockarell, Lori, additional, Drennan, Amelia, additional, Dubuque, Kathleen, additional, Fambrough, Tonya, additional, Gasaway, Nikole, additional, Krantz, Briana, additional, Nebi, Peiman, additional, Orga, Jan, additional, Serfass, Margaret, additional, Simion, Alina, additional, Warren, Kimberly, additional, Wheeler, Cassie, additional, Woolman, C.J., additional, Christie, Amy B., additional, Ashley, Dennis W., additional, Adiga, Rajani, additional, Newsome, Andrea Sikora, additional, Forehand, Christy C., additional, Bruning, Rebecca, additional, Jones, Timothy W., additional, Waikar, Sushrut S., additional, Colona, Mia, additional, Kibbelaar, Zoe, additional, Leong, Michael, additional, Wallman, Daniel, additional, Soni, Kanupriya, additional, Maccarone, Jennifer, additional, Gilman, Joshua, additional, Devis, Ycar, additional, Chung, Joseph, additional, Paracha, Munizay, additional, Lumelsky, David N., additional, DiLorenzo, Madeline, additional, Abdurrahman, Najla, additional, Johnson, Shelsey, additional, Tirupathi, Raghavendra, additional, Tang, Alymer, additional, Safi, Arshad, additional, Green, Cindy, additional, Newell, Jackie, additional, Ramani, Naga, additional, Ganti, Bhavani Harika, additional, Daugherty, Steven K., additional, Atkinson, Sam, additional, Shrimpton, Kelly, additional, Smalls, Norma, additional, Reilkoff, Ronald A., additional, Heneghan, Julia A., additional, Eichen, Sarah, additional, Goertzen, Lexie, additional, Rajala, Scott, additional, Feussom, Ghislaine, additional, Tang, Ben, additional, Cartin-Ceba, Rodrigo, additional, Sen, Ayan, additional, Talaei, Fahimeh, additional, Domecq, Juan Pablo, additional, Bansal, Vikas, additional, Tekin, Aysun, additional, Lal, Amos, additional, O'Horo, John C., additional, Deo, Neha N., additional, Sharma, Mayank, additional, Qamar, Shahraz, additional, Singh, Romil, additional, Valencia Morales, Diana J., additional, Sharma, Nikhil, additional, Khan, Syed Anjum, additional, Jain, Nitesh Kumar, additional, Koritala, Thoyaja, additional, Khedr, Anwar M., additional, Mushtaq, Hisham A., additional, Jama, Abbas B., additional, Venkata, Chakradhar, additional, Engemann, Miriam, additional, Mantese, Annamarie, additional, Aulakh, Bhagat S., additional, Tripathi, Sandeep, additional, Bandy, Jennifer A., additional, Kreps, Lisa M., additional, Bollinger, Dawn R., additional, Stienecker, Roger Scott, additional, Melendez, Andre G., additional, Brunner, Tressa A., additional, Budzon, Sue M., additional, Heffernan, Jessica L., additional, Souder, Janelle M., additional, Miller, Tracy L., additional, Maisonneuve, Andrea G., additional, Vilella, Antonia L., additional, Kutner, Sara B., additional, Clark, Kacie, additional, Moore, Danielle, additional, Zaren, Howard A., additional, Smith, Stephanie J., additional, Lewis, Grant C., additional, Seames, Lauren, additional, Farlow, Cheryl, additional, Miller, Judy, additional, Broadstreet, Gloria, additional, Martinez, Anthony, additional, Allison, Micheal, additional, Mittal, Aniket, additional, Ruiz, Rafael, additional, Skaanland, Aleta, additional, Ross, Robert, additional, Bernstein, Michael A., additional, Goff, Ian K., additional, Naftilan, Matthew, additional, Mathew, Amal, additional, Williams, Deborah, additional, Murdock, Sue, additional, Ducey, Maryanne, additional, Nelson, Kerianne, additional, Gupta, Neha, additional, Jones, Tracy L., additional, Ayers, Shonda C., additional, Harrell, Amy B., additional, Brown, Brent R., additional, Malone, Kassidy, additional, Sinko, Lauren A., additional, Settle, Lisa M., additional, Sears, Taylor J., additional, McGonagill, Patrick W., additional, Galet, Colette, additional, Hubbard, Janice, additional, Wang, David, additional, Allan, Lauren, additional, Badheka, Aditya, additional, Chegondi, Madhuradhar, additional, Stapleton, Renee D., additional, Dixon, Anne E., additional, Johnson, Olivia, additional, Ardren, Sara S., additional, Burns, Stephanie, additional, Raymond, Anna, additional, Gonyaw, Erika, additional, Hodgdon, Kevin, additional, Housenger, Chloe, additional, Lin, Benjamin, additional, McQuesten, Karen, additional, Pecott-Grimm, Heidi, additional, Sweet, Julie, additional, Ventrone, Sebastian, additional, Khanna, Ashish K., additional, Harris, Lynnette, additional, Cusson, Bruce, additional, Reeves, Brandon, additional, Fanelli, Jessica, additional, Disher, Nataya, additional, Samant, Anusha, additional, DeGroot, Chritian, additional, Youshock, Evan, additional, Ligon, R. Miller, additional, McCartney, Katherine, additional, Garcia, Julio, additional, Iloabachie, Chidi, additional, Flores, Kelsey, additional, VanEenenaam, David, additional, Sands, Lauren, additional, Robinson, Samuel, additional, Sweatt, Nia, additional, Fowler, Jacob, additional, Fram, Madeline, additional, Howard, Easton, additional, Johnson, Kathleen, additional, Udoh, Imoh, additional, Nosow, Lillian, additional, Howard, Lucy Winesett, additional, Minh Pham, Quan Duc, additional, Irfanullah, Aman, additional, Ong, Tiffany, additional, Enwezor, Chukwunyelu Henry, additional, Dabagian, Hannah, additional, and Mendoza, Rafael, additional

Published
2024
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5. Hospital Variation in Management and Outcomes of Acute Respiratory Distress Syndrome Due to COVID-19

Author

Johnson, Shelsey W., Garcia, Michael A., Sisson, Emily K. Q., Sheldrick, Christopher R., Kumar, Vishakha K., Boman, Karen, Bolesta, Scott, Bansal, Vikas, Lal, Amos, Domecq, J. P., Melamed, Roman R., Christie, Amy B., Husain, Abdurrahman, Yus, Santiago, Gajic, Ognjen, Kashyap, Rahul, Walkey, Allan J., Gavidia, Oscar Y., Pachon, Felipe, Sanchez, Yeimy A., Kassas, Mohamed El, Badr, Mohamed, Tawheed, Ahmed, Tawheed, Ahmed, Yahia, Hend, Matsuda, Wataru, Suzuki, Reina, Suzuki, Reina, Sanui, Masamitsu, Horikita, Sho, Itagaki, Yuki, Kodate, Akira, Suzuki, Reina, Kodate, Akira, Takahashi, Yuki, Moriki, Koyo, Sohaib, Muhammad, Syed, Asghar Mashaal, Anosh, Syed, Naqvi, Ali, Zabolotskikh, Borisovich, Zybin, Konstantin Dmitrievich, Sinkov, Sergey Vasilevich, Musaeva, Tatiana Sergeevna, Almazyad, Mohammed A., Alarifi, Mohammed I., Macarambon, Jara M., Bukhari, Ahmad Abdullah, Albahrani, Hussain A., Asfina, Kazi N., Aldossary, Kaltham M., Zdravkovic, Marija, Todorovic, Zoran, Popadic, Viseslav, Klasnja, Slobodan, Stevanovic, Predrag D., Stojakov, Dejan S., Ignjatovic, Duska K., Bojic, Suzana C., Bobos, Marina M., Nenadic, Irina B., Zaric, Milica S., Djuric, Marko D., Djukic, Vladimir R., Yus, Santiago, Martin, Belen C., Sili, Uluhan, Bilgin, Huseyin, Ay, Pinar, Melamed, Roman R., Tierney, David M., Patel, Love A., Raj, Vino S., Dawud, Barite U., Mazumder, Narayana, Sidebottom, Abbey, Guenther, Alena M., Krehbiel, Benjamin D., Schmitz, Nova J., Jepsen, Stacy L., Sipsey, Lynn, Schulte, Anna, Wunderlich, Whitney, Hoyt, Cecely, Dodd, Kenneth W., Goodmanson, Nicholas, Hesse, Kathleen, Bird, Paige, Weinert, Chauncey, Schoenrade, Nathan, Altaher, Abdulrahman, Mayar, Esmael, Aronson, Matthew, Cooper, Tyler, Logan, Monica, Miner, Brianna, Papo, Gisele, Al-Fares, Abdulrahman, Kharbanda, Anmol, Jhajhria, Sunil, Fyffe, Zachary, Christie, Amy B., Ashley, Dennis W., Adiga, Rajani, Newsome, Andrea Sikora, Forehand, Christy C., Bruning, Rebecca, Jones, Timothy W., Sabov, Moldovan, Zaidi, Fatema, Tissavirasingham, Fiona, Malipeddi, Dhatri, Banner-Goodspeed, Valerie M., Bose, Somnath, Kelly, Lauren E., Joseph, Melisa, McGourty, Marie, Capers, Krystal, Hoenig, Benjamin, Karamourtopoulos, Maria C., Law, Anica C., Baedorf Kassis, Elias N., Walkey, Allan J., Waikar, Sushrut S., Garcia, Michael A., Colona, Mia, Kibbelaar, Zoe, Leong, Michael, Wallman, Daniel, Soni, Kanupriya, Maccarone, Jennifer, Gilman, Joshua, Devis, Ycar, Chung, Joseph, Paracha, Munizay, Lumelsky, David N., DiLorenzo, Madeline, Abdurrahman, Najla, Johnson, Shelsey, Zammit, Kimberly, McGrath, Patrick J., Loeffler, William, Chilbert, Maya R., Mesland, Jean-Baptiste, Henin, Pierre, Petre, Hélène, Buelens, Isabelle, Gerard, Anne-Catherine, Ihle, Rayan E., Martin, Shelda A., Davis, Elaine A., Surani, Salim, White, Joshua, Khan, Aftab, Dhahwal, Rahul, Cheruku, Sreekanth, Ahmed, Farzin, Deonarine, Christopher, Jones, Ashley, Shaikh, Mohammad-Ali, Preston, David, Chin, Jeanette, Daugherty, Steven K., Atkinson, Sam, Shrimpton, Kelly, Bartz, Raquel R., Krishnamoorthy, Vijay, Kraft, Bryan, Pulsipher, Aaron, Friedman, Eugene, Mehta, Sachin, Yamane, David P., Benjenk, Ivy, Prasanna, Nivedita, Nault, Katharine, Reilkoff, Ronald A., Heneghan, Julia A., Eichen, Sarah, Goertzen, Lexie, Rajala, Scott, Feussom, Ghislaine, Tang, Ben, Arizona, Mayo Clinic, Cartin-Ceba, Rodrigo, Sen, Ayan, Palacios, Amanda, Mahdi, Giyth M., Kashyap, Rahul, Gajic, Ognjen, Bansal, Vikas, Tekin, Aysun, Lal, Amos, O’Horo, John C., Deo, Neha N., Sharma, Mayank, Qamar, Shahraz, Domecq, Juan Pablo, Singh, Romil, Niven, Alex, Clinic, Mayo, Claire, Eau, La Nou, Abigail T., Bogojevic, Marija, Mullen, Barbara, Sanghavi, Devang, Guru, Pramod, Franco, Pablo Moreno, Gnanapandithan, Karthik, Saunders, Hollie, Fleissner, Zachary, Garcia, Juan, Yu Lee Mateus, Alejandra, Yarrarapu, Siva Naga, Kaur, Nirmaljot, Giri, Abhisekh, Khan, Syed Anjum, Jain, Nitesh Kumar, Koritala, Thoyaja, Venkata, Chakradhar, Engemann, Miriam, Mantese, Annamarie, Tarabichi, Yasir, Perzynski, Adam, Wang, Christine, Kotekal, Dhatri, Aulakh, Bhagat S., Tripathi, Sandeep, Bandy, Jennifer A., Kreps, Lisa M., Bollinger, Dawn R., Bandy, Jennifer A., Stienecker, Roger Scott, Melendez, Andre G., Brunner, Tressa A., Budzon, Sue M., Heffernan, Jessica L., Souder, Janelle M., Miller, Tracy L., Maisonneuve, Andrea G., Vilella, Antonia L., Kutner, Sara B., Clark, Kacie, Moore, Danielle, Anderson, Harry L., III, Rajkumar, Dixy, Abunayla, Ali, Heiter, Jerrilyn, Zaren, Howard A., Smith, Stephanie J., Lewis, Grant C., Seames, Lauren, Farlow, Cheryl, Miller, Judy, Broadstreet, Gloria, Martinez, Anthony, Allison, Micheal, Mittal, Aniket, Ruiz, Rafael, Skaanland, Aleta, Ross, Robert, Gupta, Neha, Jones, Tracy L., Ayers, Shonda C., Harrell, Amy B., Brown, Dr. Brent R., Husain, Abdurrahman, Malhotra, Atul, Zawaydeh, Qais, Markotić, Dragana, Bošnjak, Ivana, Vail, Emily A., Nicholson, Susannah, Jonas, Rachelle B., Dement, AnnaRose E., Tang, William, DeRosa, Mark, Villarreal, Robert E., McGonagill, Patrick W., Galet, Colette, Hubbard, Janice, Wang, David, Allan, Lauren, Badheka, Aditya, Chegondi, Madhuradhar, Alvarez, Roger A., Alarcon-Calderon, Amarilys, Sosa, Marie Anne, Mahabir, Sunita K., Patel, Mausam J., Shah, Faraaz Ali, Chuan, Byron, Rawal, Sagar L., Piracha, Manal, Tonna, Joseph E., Levin, Nicholas M., Suslavich, Kayte, Tsolinas, Rachel, Fica, Zachary T., Skidmore, Chloe R., Stapleton, Renee D., Dixon, Anne E., Johnson, Olivia, Ardren, Sara S., Burns, Stephanie, Raymond, Anna, Gonyaw, Erika, Hodgdon, Kevin, Housenger, Chloe, Lin, Benjamin, McQuesten, Karen, Pecott-Grimm, Heidi, Sweet, Julie, Ventrone, Sebastian, Akhter, Murtaza, Rahman, Rania Abdul, Mulrow, Mary, Khanna, Ashish K., Harris, Lynne, Cusson, Bruce, Fowler, Jacob, Vaneenenaam, David, McKinney, Glen, Udoh, Imoh, Johnson, Kathleen, Pattan, Vishwanath, Papke, Jessica, Jimada, Ismail, Mhid, Nida, and Chakola, Samuel

Published
2022
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6. Role of caveolin-1 in thyroid phenotype, cell homeostasis, and hormone synthesis: in vivo study of caveolin-1 knockout mice

Author

Senou, Maximin, Costa, Maria Jose, Massart, Claude, Thimmesch, Matthieu, Khalifa, Celine, Poncin, Sylvie, Boucquey, Marie, Gerard, Anne-Catherine, Audinot, Jean-Nicolas, Dessy, Chantal, Ruf, Jean, Feron, Olivier, Devuyst, Olivier, Guiot, Yves, Dumont, Jacques Emile, Van Sande, Jacqueline, and Many, Marie-Christine

Subjects
Homeostasis -- Physiological aspects, Homeostasis -- Genetic aspects, Homeostasis -- Research, Oxidative stress -- Physiological aspects, Oxidative stress -- Control, Oxidative stress -- Research, Thyroid hormones -- Physiological aspects, Thyroid hormones -- Genetic aspects, Thyroid hormones -- Research, Biological sciences
Abstract

In human thyroid, caveolin-1 is localized at the apex of thyrocytes, but its role there remains unknown. Using immunohistochemistry, [sup.127]I imaging, transmission electron microscopy, immunogold electron microscopy, and quantification of [H.sub.2][O.sub.2], we found that in caveolin-1 knockout mice thyroid cell homeostasis was disrupted, with evidence of oxidative stress, cell damage, and apoptosis. An even more striking phenotype was the absence of thyroglobulin and iodine in one-half of the follicular lumina and their presence in the cytosol, suggesting that the iodide organification and binding to thyroglobukin were intracellular rather than at the apical membrane/ extracellular colloid interface. The latter abnormality may be secondary to the observed mislocalization of the thyroid hormone synthesis machinery (dual oxidases, thyroperoxidase) in the cytosol. Nevertheless, the overall uptake of radioiodide, its organification, and secretion as thyroid hormones were comparable to those of wild-type mice, suggesting adequate compensation by the normal TSH retrocontrol. Accordingly, the levels of free thyroxine and TSH were normal. Only the levels of free triiodothyronine showed a slight decrease in caveolin-1 knockout mice. However, when TSH levels were increased through low-iodine chow and sodium perchlorate, the induced goiter was more prominent in caveolin-1 knockout mice. We conclude that caveolin-1 plays a role in proper thyroid hormone synthesis as well as in cell number homeostasis. Our study demonstrates for the first time a physiological function of caveolin-1 in the thyroid gland. Because the expression and subcellular localization of caveolin-1 were similar between normal human and murine thyroids, our findings in caveolin-1 knockout mice may have direct relevance to the human counterpart. dual oxidase; thyroperoxidase; iodination; thyrocytes; hydrogen peroxide; oxidative stress; thyroid hormone synthesis; iodide

Published
2009

7. Iodide deficiency-induced angiogenic stimulus in the thyroid occurs via HIF-and ROS-dependent VEGF-A secretion from thyrocytes

Author

Gerard, Anne-Catherine, Poncin, Sylvie, Audinot, Jean-Nicolas, Denef, Jean-Francois, and Colin, Ides M.

Subjects
Iodides -- Physiological aspects, Iodides -- Research, Thyroid gland -- Physiological aspects, Thyroid gland -- Research, Vascular endothelial growth factor -- Physiological aspects, Vascular endothelial growth factor -- Research, Biological sciences
Abstract

Vascular supply is an obvious requirement for all organs. In addition to oxygen and nutrients, blood flow also transports essential trace elements. Iodine, which is a key element in thyroid hormone synthesis, is one of them. An inverse relationship exists between the expansion of the thyroid microvasculature and the local availability of iodine. This microvascular trace element-dependent regulation is unique and contributes to keep steady the iodide delivery to the thyroid. Signals involved in this regulation, such as VEGF-A, originate from thyrocytes as early TSH-independent responses to iodide scarcity. The question raised in this paper is how thyrocytes, facing an acute drop in intracellular stores of iodine, generate angiogenic signals acting on adjacent capillaries. Using in vitro models of rat and human thyroid cells, we show for the first time that the deficit in iodine is related to the release of VEGF-A via a reactive oxygen species/hypoxia-inducible factor-1-dependent pathway. thyroid function; angiogenesis; vascular endothelial growth factor A; oxidative stress; hypoxia-inducible factor; reactive oxygen species

Published
2009

8. Expression of TPO and ThOXs in human thyrocytes is downregulated by IL-1[alpha]/IFN-[gamma], an effect partially mediated by nitric oxide

Author

Gerard, Anne-Catherine, Boucquey, Marie, van den Hove, Marie-France, and Colin, Ides M.

Subjects
Thyroiditis -- Research, Nitric oxide -- Properties, Biological sciences
Abstract

Morphological and functional alterations in Hashimoto's thyroiditis (HT) are predominantly mediated by Th1 cytokines through apoptotic cell death. This ultimate step could be preceded by functional injuries in thyroid hormone synthesis. The action of two Th1 cytokines (IL-1[alpha]/ IFN-[gamma]) on thyroperoxidase (TPO) and thyroid oxidase (ThOXs) expression was tested in human thyrocytes isolated from normal tissues, Graves' disease (GD) tissues, and autonomous toxic nodules. There was no evidence of cell death. Nitric oxide (NO) release was induced by cytokines but was absent when [N.sup.G]-nitro-L-arginine methyl ester (L-NAME) was coincubated. When thyrotropin (TSH)-incubated normal and GD thyrocytes were treated with IL-1[alpha]/IFN-[alpha], TPO and ThOXs protein and mRNA expression dropped, a decrease partially prevented by L-NAME, suggesting that NO acts as a mediator of Th1 effects. In thyrocytes from autonomous toxic nodules, the high level of TPO and ThOXs protein expression was not influenced by TSH or by cytokines, a finding partially reproduced when normal thyrocytes were treated with increasing concentrations of TSH. In conclusion, incubation of normal or GD thyrocytes with Th1 cytokines induces a significant reduction in TSH-increased expression of both TPO and ThOXs, an effect partially mediated by NO. The thyroid cell function can therefore be severely affected in HT, even when cells remain viable. In autonomous toxic nodules, cells become partially insensitive to exogenous Th1 cytokines. Th1 cytokines; Hashimoto's thyroiditis; thyroid oxidase; thyroperoxidase; interleukin-1[alpha]; interferon-[gamma] doi:10.1152/ajpendo.00439.2005

Published
2006

11. Iodine deficiency-induced long lasting angiogenic reaction in thyroid cancers occurs via a VEGF-HIF-1, but not a ROS dependent pathway.

Author

Gerard, Anne-Catherine, primary, Humblet, Kevin, additional, Wilvers, Cindy, additional, Poncin, Sylvie, additional, Derradji, Hanane, additional, de Ville de Goyet, Christine, additional, Abou-el-Ardat, Khalil, additional, Baatout, Sarah, additional, Sonveaux, Pierre, additional, Denef, Jean-François, additional, and Colin, Ides M, additional

Published
2012
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12. Expression of TPO and ThOXs in human thyrocytes is downregulated by IL-1α/IFN-γ, an effect partially mediated by nitric oxide.

Author

Gerard, Anne-Catherine, Boucquey, Marie, Van Den Hove, Marie-France, and Cohn, Ides M.

Subjects
*AUTOIMMUNE thyroiditis, *AUTOIMMUNE diseases, *CYTOKINES, *CELL death, *MESSENGER RNA, *APOPTOSIS, *NITRIC oxide
Abstract

Morphological and functional alterations in Hashimoto's thyroiditis (HT) are predominantly mediated by Th1 cytokines through apoptotic cell death. This ultimate step could be preceded by functional injuries in thyroid hormone synthesis. The action of two Th1 cytokines (IL-1α/IFN-γ) on thyroperoxidase (TPO) and thyroid oxidase (ThOXs) expression was tested in human thyrocytes isolated from normal tissues, Graves' disease (GD) tissues, and autonomous toxic nodules. There was no evidence of cell death. Nitric oxide (NO) release was induced by cytokines but was absent when NG-nitro-L-arginine methyl ester (L-NAME) was coincubated. When thyrotropin (TSH)-incubated normal and GD thyrocytes were treated with IL-1α/IFN-γ, TPO and ThOXs protein and mRNA expression dropped, a decrease partially prevented by L-NAME, suggesting that NO acts as a mediator of Th1 effects. In thyrocytes from autonomous toxic nodules, the high level of TPO and ThOXs protein expression was not influenced by TSH or by cytokines, a finding partially reproduced when normal thyrocytes were treated with increasing concentrations of TSH. In conclusion, incubation of normal or GD thyrocytes with Th1 cytokines induces a significant reduction in TSH-increased expression of both TPO and ThOXs, an effect partially mediated by NO. The thyroid cell function can therefore be severely affected in HT, even when cells remain viable. In autonomous toxic nodules, cells become partially insensitive to exogenous Th1 cytokines. [ABSTRACT FROM AUTHOR]

Published
2006
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