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205 results on '"Geracioti, Thomas"'

4. Pronounced and Sustained Central Hypernoradrenergic Function in Major Depression with Melancholic Features: Relation to Hypercortisolism and Corticotropin-Releasing Hormone

Author

Wong, Ma-Li, Kling, Mitchel A., Munson, Peter J., Listwak, Samuel, Licinio, Julio, Prolo, Paolo, Karp, Brian, McCutcheon, Ian E., Geracioti,, Thomas D., DeBellis, Michael D., Rice, Kenner C., Goldstein, David S., Veldhuis, Johannes D., Chrousos, George P., Oldfield, Edward H., McCann, Samuel M., and Gold, Philip W.

Published
2000

6. Cerebrospinal Fluid and Plasma Leptin Measurements: Covariability with Dopamine and Cortisol in Fasting Humans*

Author

Hagan, Mary M, Havel, Peter J, Seeley, Randy J, Woods, Stephen C, Ekhator, Nosa N, Baker, Dewleen G, Hill, Kelly K, Wortman, Matthew D, Miller, Andrew H, Gingerich, Ronald L, and Geracioti, Thomas D

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Obesity, Clinical Research, Nutrition, Neurosciences, Metabolic and endocrine, Stroke, Adult, Body Mass Index, Circadian Rhythm, Dopamine, Fasting, Humans, Hydrocortisone, Leptin, Male, Middle Aged, Smoking, Stress Disorders, Post-Traumatic, Clinical Sciences, Paediatrics and Reproductive Medicine, Endocrinology & Metabolism, Clinical sciences
Abstract

Leptin (OB protein) is an important signal in the regulation of energy balance. Leptin levels correlate with adiposity, but also decrease acutely with caloric restriction and increase with refeeding. The brain is an established critical site of leptin function, yet little is known about leptin concentrations in the central nervous system relative to plasma levels, psychiatric diagnoses, and other endocrine parameters. Therefore, using a novel ultrasensitive leptin assay, we explored relationships of human plasma and cerebrospinal fluid (CSF) leptin levels to body mass index, smoking, posttraumatic stress disorder diagnosis, and levels of dopamine, monoamine metabolites, beta-lipotropin, glucocorticoid, and thyroid and cytokine hormones. A strong linear relation between CSF and plasma leptin levels in the am (r = 0.63; P < 0.002) and afternoon (r = 0.90; P < 0.0001) was revealed. CSF and plasma leptin concentrations decreased during a 12- to 20-h period of fasting. A strong association was found between plasma leptin and CSF dopamine levels (r = 0.74; P < 0.01) as well as between CSF leptin levels and urinary free cortisol (r = 0.73; P < 0.01). Both of these parameters covaried with leptin independently of adiposity, as estimated by body mass index. Implications for leptin transport, regulation, and its potential role in therapeutic strategies for obesity and diabetes are discussed.

Published
1999

15. NPY

Author

Baker, Dewleen G, primary, Hauger, Richard L, additional, Bertram, Tobias Moeller, additional, Patel, Piyush M, additional, Barkauskas, Donald A, additional, Clopton, Paul, additional, Geracioti, Thomas D, additional, O'Connor, Daniel T, additional, and Nievergelt, Caroline M, additional

Published
2014
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31. Fasting and postprandial cerebrospinal fluid glucose concentrations in healthy women and in an obese binge eater

Author

Geracioti, Thomas D., Loosen, Peter T., Ebert, Michael H., Schmidt, Dennis, and Ekhator, Nosa N.

Subjects
Cerebrospinal fluid -- Analysis, Glucose metabolism -- Observations, Bulimia -- Research, Food/cooking/nutrition, Psychology and mental health
Abstract

The postprandial cerebrospinal fluid (CSF) glucose concentration remains unchanged in the obese patient with binge eating disorder and bipolar depression studied after consumption of a glucose-rich, mixed liquid meal. The fasting serum glucose level is normal and fasting CSF glucose concentration is lower in the bulimic patient than in normal women. The low level of postprandial passage of glucose in the central nervous system may lead to the binge eating.

Published
1995

37. Regulation of appetite and cholecystokinin secretion in anorexia nervosa

Author

Geracioti, Thomas D., Jr., Liddle, Rodger A., Altemus, Margaret, Demitrack, Mark A., and Gold, Philip W.

Subjects
Anorexia nervosa -- Physiological aspects, cholecystokinin -- Physiological aspects, Appetite -- Physiological aspects, Health, Psychology and mental health
Abstract

Six patients with anorexia nervosa, the same patients after weight normalization, and six healthy control subjects had similar fasting and postprandial plasma cholecystokinin concentrations. These data do not support the hypothesis that low levels of hunger and food intake in anorexic patients reflect hypersecretion of this endogenous hormone, which is thought to inhibit hunger, promote satiety, and reduce feeding. (Am J Psychiatry 1992; 149:958-961)

Published
1992

40. Corrigendum to “Low cerebrospinal fluid and plasma orexin-A (hypocretin-1) concentrations in combat-related posttraumatic stress disorder” [Psychoneuroendocrinology 35 (7) (2010) 1001–1007]

Author

Strawn, Jeffrey R., primary, Pyne-Geithman, Gail J., additional, Ekhator, Nosakhare N., additional, Horn, Paul S., additional, Uhde, Thomas W., additional, Shutter, Lori A., additional, Baker, Dewleen G., additional, and Geracioti, Thomas D., additional

Published
2016
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