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1,116 results on '"Georgieff, Michael K."'

2. Effect of Malaria and Malaria Chemoprevention Regimens in Pregnancy and Childhood on Neurodevelopmental and Behavioral Outcomes in Children at 12, 24, and 36 Months: A Randomized Clinical Trial

Author

Bangirana, Paul, Conroy, Andrea L, Opoka, Robert O, Semrud-Clikeman, Margaret, Jang, Jeong H, Apayi, Claire, Kakuru, Abel, Muhindo, Mary K, Georgieff, Michael K, Dorsey, Grant M, Kamya, Moses R, Havlir, Diane, and John, Chandy C

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, Behavioral and Social Science, Neurosciences, Mental Health, Prevention, Vector-Borne Diseases, Clinical Trials and Supportive Activities, Infectious Diseases, Malaria, Rare Diseases, Clinical Research, 3.3 Nutrition and chemoprevention, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Prevention of disease and conditions, and promotion of well-being, Reproductive health and childbirth, Good Health and Well Being, Child, Female, Pregnancy, Humans, Antimalarials, Pyrimethamine, Sulfadoxine, Artemisinins, Drug Combinations, Quinolines, Chemoprevention, malaria, chemoprevention, pregnancy, development, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundMalaria in pregnancy has been associated with worse cognitive outcomes in children, but its association with behavioral outcomes and the effectiveness of malaria chemoprevention on child neurodevelopment are not well characterized.MethodsTo determine if more effective malaria chemoprevention in mothers and their children results in better neurodevelopment, 305 pregnant women were randomly assigned to 3 doses of sulfadoxine-pyrimethamine, 3 doses of dihydroartemisinin-piperaquine (DP), or monthly DP during pregnancy, and their 293 children were assigned to DP every 3 months or monthly DP from 2 to 24 months of age. Cognition, language, and motor function were assessed at 12, 24. and 36 months of age, and attention, memory, behavior, and executive function were assessed at 24 and 36 months of age.ResultsChildren of mothers with versus without malaria in pregnancy had worse scores on cognitive, behavioral, and executive function outcomes at 24 months. Clinical malaria in children within the first 12 months was similarly associated with poorer scores in behavior and executive function at 24 months, language at 24 and 36 months, and motor function scores at 36 months. However, more effective malaria chemoprevention in the mothers and children was not associated with better outcomes.ConclusionsMalaria in pregnancy was associated with worse cognitive, behavioral, and executive function scores in affected children, but more effective malaria chemoprevention measures did not result in better outcomes. Malaria chemoprevention prior to and early in gestation and with even higher efficacy in mothers and children may be required to prevent neurodevelopmental impairment in children. Clinical Trials Registration. NCT02557425.

Published
2023

8. RAPIDIRON Trial follow-up study — the RAPIDIRON-KIDS Study: protocol of a prospective observational follow-up study

Author

Derman, Richard J., Bellad, Roopa B., Bellad, Mrutyunjaya B., Bradford-Rogers, Jesse, Georgieff, Michael K., Aghai, Zubair H., Thind, Simal, Auerbach, Michael, Boelig, Rupsa, Leiby, Benjamin E., Short, Vanessa, Yogeshkumar, S., Charantimath, Umesh S., Somannavar, Manjunath S., Mallapur, Ashalata A., Pol, Ramesh, Ramadurg, Umesh, Sangavi, Radha, Peerapur, Basavaraj V., Banu, Nasima, Patil, Praveen S., Patil, Amaresh P., Roy, Subarna, Vastrad, Phaniraj, Wallace, Dennis, Shah, Hemang, and Goudar, Shivaprasad S.

Published
2023
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14. Nutrition and Brain Development

Author

Cusick, Sarah E., Barks, Amanda, Georgieff, Michael K., Geyer, Mark A., Series Editor, Marsden, Charles A., Series Editor, Ellenbroek, Bart A., Series Editor, Barnes, Thomas R. E., Series Editor, Andersen, Susan L., Series Editor, and Paulus, Martin P., Series Editor

Published
2022
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19. Persistent Changes in Stress‐Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol

Author

Sarkar, Dipak K, Gangisetty, Omkaram, Wozniak, Jeffrey R, Eckerle, Judith K, Georgieff, Michael K, Foroud, Tatiana M, Wetherill, Leah, Wertelecki, Wladimir, Chambers, Christina D, Riley, Edward, Zymak‐Zakutnya, Natalya, and Yevtushok, Lyubov

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Brain Disorders, Intellectual and Developmental Disabilities (IDD), Substance Misuse, Genetics, Pediatric, Fetal Alcohol Spectrum Disorders (FASD), Alcoholism, Alcohol Use and Health, Clinical Research, Conditions Affecting the Embryonic and Fetal Periods, Perinatal Period - Conditions Originating in Perinatal Period, Aetiology, 2.2 Factors relating to the physical environment, Reproductive health and childbirth, Cancer, Good Health and Well Being, Adolescent, Adult, Case-Control Studies, Central Nervous System Depressants, Child, Child, Preschool, Choline, DNA Methylation, Dietary Supplements, Epigenesis, Genetic, Ethanol, Female, Fetal Alcohol Spectrum Disorders, Gene Expression Regulation, Humans, Lipotropic Agents, Male, Period Circadian Proteins, Pregnancy, Prenatal Exposure Delayed Effects, Pro-Opiomelanocortin, Gene Expression, FASD, Circadian, Stress Axis, Clinical Sciences, Neurosciences, Psychology, Substance Abuse, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

BackgroundWe have recently shown that binge or heavy levels of alcohol drinking increase deoxyribonucleic acid (DNA) methylation and reduce gene expression of proopiomelanocortin (POMC) and period 2 (PER2) in adult human subjects (Gangisetty et al., Alcohol Clin Exp Res, 43, 2019, 212). One hypothesis would be that methylation of these 2 genes is consistently associated with alcohol exposure and could be used as biomarkers to predict risk of prenatal alcohol exposure (PAE). Results of the present study provided some support for this hypothesis.MethodsWe conducted a series of studies to determine DNA methylation changes in stress regulatory genes proopiomelanocortin (POMC) and period 2 (PER2) using biological samples from 3 separate cohorts of patients: (i) pregnant women who consumed moderate-to-high levels of alcohol or low/unexposed controls, (ii) children with PAE and non-alcohol-exposed controls, and (iii) children with PAE treated with or without choline.ResultsWe found pregnant women who consumed moderate-to-high levels of alcohol and gave birth to PAE children had higher DNA methylation of POMC and PER2. PAE children also had increased methylation of POMC and PER2. The differences in the gene methylation of PER2 and POMC between PAE and controls did not differ by maternal smoking status. PAE children had increased levels of stress hormone cortisol and adrenocorticotropic hormone. Choline supplementation reduced DNA hypermethylation and increased expression of POMC and PER2 in children with PAE.ConclusionsThese data suggest that PAE significantly elevates DNA methylation of POMC and PER2 and increases levels of stress hormones. Furthermore, these results suggest the possibility that measuring DNA methylation levels of PER2 and POMC in biological samples from pregnant women or from children may be useful for identification of a woman or a child with PAE.

Published
2019

24. Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes

Author

Gimbel, Blake A., Anthony, Mary E., Ernst, Abigail M., Roediger, Donovan J., de Water, Erik, Eckerle, Judith K., Boys, Christopher J., Radke, Joshua P., Mueller, Bryon A., Fuglestad, Anita J., Zeisel, Steven H., Georgieff, Michael K., and Wozniak, Jeffrey R.

Published
2022
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28. Contributors

Author

Abrams, Elissa M., primary, Agostoni, Carlo, additional, Andreae, Doerthe A., additional, Berti, Cristiana, additional, Bhutta, Zulfiqar A., additional, Burton, Mark A., additional, Catassi, Carlo, additional, Closa-Monasterolo, Ricardo, additional, Cusick, Sarah E., additional, Dattilo, Anne M., additional, Subias, Joaquin Escribano, additional, Pallas, Natalia Ferré, additional, Fisher, Jennifer Orlet, additional, Fleischer, David M., additional, Georgieff, Michael K., additional, Giannì, Maria Lorella, additional, Godfrey, Keith M., additional, Guz-Mark, Anat, additional, Hart, Tricia L., additional, Iglesia, Edward G.A., additional, Kalhoff, Hermann, additional, Kalliomäki, Marko, additional, Kersting, Mathilde, additional, Kris-Etherton, Penny M., additional, Lafeber, Harrie N., additional, Laitinen, Kirsi, additional, Lassi, Zohra S., additional, Lillycrop, Karen A., additional, Lionetti, Elena, additional, Moreno, Veronica Luque, additional, Mokkala, Kati, additional, Morniroli, Daniela, additional, Mosca, Fabio, additional, Nowak-Wegrzyn, Anna, additional, O’Neill, Lynda M., additional, Oken, Emily, additional, Padhani, Zahra A., additional, Perng, Wei, additional, Petersen, Kristina S., additional, Sundseth Ross, Erin, additional, Ruys, Charlotte A., additional, Saavedra, Jose M., additional, Salam, Rehana A., additional, Salvatore, Silvia, additional, Shamir, Raanan, additional, van de Lagemaat, Monique, additional, van den Akker, Chris H.P., additional, van Goudoever, Johannes B., additional, Vandenplas, Yvan, additional, Vickers, Mark H., additional, and Vizzari, Giulia, additional

Published
2022
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37. Infants of Diabetic Mothers

Author

Osterholm, Erin A., Barthell, Jane E., Georgieff, Michael K., Buonocore, Giuseppe, editor, Bracci, Rodolfo, editor, and Weindling, Michael, editor

Published
2018
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42. Neonatal medical exposures and characteristics of low birth weight hepatoblastoma cases: A report from the Children's Oncology Group

Author

Turcotte, Lucie M, Georgieff, Michael K, Ross, Julie A, Feusner, James H, Tomlinson, Gail E, Malogolowkin, Marcio H, Krailo, Mark D, Miller, Nicole, Fonstad, Rachel, and Spector, Logan G

Subjects
Paediatrics, Biomedical and Clinical Sciences, Clinical Research, Infant Mortality, Cancer, Pediatric Cancer, Prevention, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Preterm, Low Birth Weight and Health of the Newborn, Pediatric Research Initiative, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, 2.4 Surveillance and distribution, Aetiology, Reproductive health and childbirth, Case-Control Studies, Gestational Age, Hepatoblastoma, Humans, Infant, Low Birth Weight, Infant, Newborn, Liver Neoplasms, Parenteral Nutrition, Total, case-control study, exposure, hepatoblastoma, low birth weight, NICU, Clinical Sciences, Oncology and Carcinogenesis, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundHepatoblastoma is a malignancy of young children. Low birth weight is associated with significantly increased risk of hepatoblastoma and neonatal medical exposures are hypothesized as contributors. This study represents the largest case-control study of hepatoblastoma to date and aimed to define the role of neonatal exposures in hepatoblastoma risk among low birth weight children.ProcedureIncident hepatoblastoma cases who were born

Published
2014

43. Differences in Oxygen-Induced Retinopathy Susceptibility Between Two Sprague Dawley Rat Vendors: A Comparison of Retinal Transcriptomes.

Author

Lee, Haeyeon, Molomjamts, Mandkhai, Roehrich, Heidi, Gudvangen, Sydney, Asuncion, Chanel, Georgieff, Michael K., Tran, Phu, McLoon, Linda K., and Ingolfsland, Ellen C.

Subjects
SPRAGUE Dawley rats, TRANSCRIPTOMES, FOCAL adhesion kinase, DIABETIC retinopathy, RETINAL injuries, RETINA
Abstract

To determine the retinal transcriptomic differences underlying the oxygen-induced retinopathy phenotypes between Sprague Dawley rat pups from two commonly used commercial vendors. This will allow us to discover genes and pathways that may be related to differences in disease severity in similarly aged premature babies and suggest possible new treatment approaches. We analyzed retinal vascular morphometry and transcriptomes from Sprague Dawley rat pups from Charles River Laboratories and Envigo (previously Harlan). Room air control and oxygen-induced retinopathy groups were compared. Oxygen-induced retinopathy was induced with the rat 50/10 model. Pups from Charles River Laboratories developed a more severe oxygen-induced retinopathy phenotype, with 3.6-fold larger percent avascular area at P15 and twofold larger % neovascular area at P20 than pups from Envigo. Changes in retinal transcriptomes of rat pups from both vendors were substantial at baseline and in response to oxygen-induced retinopathy. Baseline differences centered on activated pathways of neuronal development in Charles River Laboratories pups. In response to oxygen-induced retinopathy, during the neovascular phase, retinas from Charles River Laboratories pups exhibited activation of pathways regulating necrosis, neuroinflammation, and interferon signaling, supporting the observed increase of neovascularization. Conversely, retinas from Envigo pups showed decreased necrosis and increased focal adhesion kinase signaling, supporting more normal vascular development. Comparing oxygen-induced retinopathy transcriptomes at P15 to those at P20, canonical pathways such as phosphate and tensin homolog, interferon, and coordinated lysosomal expression and regulation element signaling were identified, highlighting potential novel mechanistic targets for future research. Transcriptomic profiles differ substantially between rat pup retinas from Charles River Laboratories and Envigo at baseline and in response to oxygen-induced retinopathy, providing insight into vascular morphologic differences. Comparing transcriptomes identified new pathways for further research in oxygen-induced retinopathy pathogenesis and increased scientific rigor of this model. [ABSTRACT FROM AUTHOR]

Published
2024
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44. 2 Choline as a neurodevelopmental intervention for children with fetal alcohol spectrum disorder: Long-term associations with white matter microstructure and executive function

Author

Gimbel, Blake A., primary, Anthony, Mary E., additional, Ernst, Abigail M., additional, Roediger, Donovan J., additional, de Water, Erik, additional, Eckerle, Judith K., additional, Boys, Christopher J., additional, Radke, Joshua P., additional, Mueller, Bryon A., additional, Fuglestad, Anita J., additional, Zeisel, Steven H., additional, Georgieff, Michael K., additional, and Wozniak, Jeffrey R., additional

Published
2023
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