Search

Since the fall of 1956, 1 granulomas of the axillae following the use of a stick type deodorant containing sodium zirconium lactate have been reported in increasing numbers. Their location has been invariably confined to the axillae, and they appear as reddish-brown discrete papules, 1 to 4 mm. in diameter. Shelley and Hurley 2 have recently reviewed 64 cases previously reported and added 6 of their own. To date, there has been no evidence of skin reactions following the use of the insoluble hydrous zirconium oxide which has long been used in large quantities for treatment of Rhus dermatitis. 3 The following report consists of two additional patients with zirconium granulomas, one of which occurred on the glabrous surfaces of both forearms and neck after repeated applications of hydrous zirconium oxide over an 18-month period. Report of Cases Case1.—A 50-year-old Caucasian woman was treated

ALLERGENS causing skin sensitization also can result in allergic contact reactions of mucous membranes including cheilitis, stomatitis, proctitis, and pruritus ani. The present case illustrates an unusual cause of such allergy from the fruit of the female ginkgo tree. Report of a Case A 63-year-old man was observed in the Dermatology Clinic for porphyria cutaneatarda. His urinary uroporphyrins had decreased to 227μg/24 hr with abstinence from alcohol. During a scheduled return visit, perioral erythema and swelling were noted. The patient related a history of burning, tingling, and soreness of his mouth, and a thick feeling in his tongue which began that morning. He denied the ingestion of new foods, new toothpaste, chewing gum, or oral medications. Results of a physical examination showed perioral erythema, swollen lips, and erythema of the buccal mucosa, tongue, and tonsillar pillars. The patient was advised to change toothpaste, avoid chewing gum, gargle with salt water

Distinctive skin lesions with pale halos occurred in Hawaii. The asymptomatic, erythematous macules and papules, located on the face, upper extremities, and neck, resolved sponstaneously in a few days. Clinical and epidemiological evidence implicated thrips, a minute plant-eating insect, as the cause of these bizarre lesions. Thorough medical evaluation of several subjects showed them to be completely normal. Unfortunately, attempts to reproduce the lesions in volunteers were unsuccessful. Awareness of the benign nature of these lesions may prevent over treatment.

In the treatment of deep mycotic infections, amphotericin B has been shown to have a wider spectrum of activity than other antifungal agents now available.1However, the encouraging results reported in the treatment of other deep mycoses2,3have not been uniformly obtained in the treatment of disseminated coccidioidomycosis.4Because of the unusual occurrence of coccidioidal granulomas on the conjunctiva and the striking objective clinical and laboratory results obtained during an eightmonth period of treatment, the following case is reported. Report of Case In December, 1953, this 32-year-old Negro W.A.C. developed a group of nodules in the skin beneath the right breast two months after a trip through the San Joaquin Valley of California. The same month she was admitted to Letterman Army Hospital for surgical excision of the lesions, and a diagnosis of coccidioidomycosis was established histologically and by culture. She was returned to duty and remained

To the Editor:— The following is a case report of Fabry's disease. The report is submitted for the purpose of aiding in establishing the incidence of the malady. The disease is becoming recognized with increasing frequency. Report of a case:— This 24-year-old white man relates that he has had a rash about his leg and inguinal areas since early childhood. The patient has been aware of easy tiring and lack of sweating. In addition, he has described episodes of "bone pain" involving the arm and leg, which are brought about by temperature changes and by exercise and generally are relieved by rest. The patient does not recall any episodes of unexplained fever as a child. The patient's mother, brother, one male cousin, and two great-uncles (one of which died at age 45 of unknown cause) have bone pains and a skin rash allegedly similar to that of the patient. All

The second case of a variant of Kyrle's disease limited to the palmar creases of the hands is presented. Although the histopathologic picture is similar, the clinical features of Kyrle's original description and the present case are markedly different. The role of trauma in producing the disease is discussed.

Amphotericin B is an antifungal antibiotic formed by a species of Streptomyces isolated from a soil sample obtained near the Orinoco River in South America. It has been shown to possess in vivo antifungal activity against experimentally induced coccidioidal infection in mice, and its action is similar to that of nystatin, in which coccidioidocidal activity has been demonstrated in vitro. 1 Although poorly absorbed from the gastrointestinal tract, amphotericin B has been shown to produce measurable blood levels when administered orally 2 and has recently been reported to be effective in the treatment of cutaneous coccidioidal granuloma when given by mouth over a period of three months. 3 Encouraging results were also obtained with the intravenous use of the drug in five stilbamidine-resistant patients having systemic North American blastomycosis. 4 The following report is of a case in which amphotericin B was administered both orally and intravenously

A 3-year-old boy developed anorexia, oliguria, central nervous system (CNS) irritation, and a generalized erythematous desquamation of the skin after application of a medicated talcum powder containing boric acid. Nine months later low urine specific gravity was still present. The subject of boric acid intoxication is reviewed.

Three cases of Mondor's disease (superficial thrombophlebitis of the chest wall) are reported. One case is unusual due to the bilateral chest wall involvement, and its appearance in a man with a systemic lupus erythematosus-like syndrome probably induced by procainamide hydrochloride. Two cases occurred unilaterally in women shortly after breast surgery.