Search

Your search keyword '"George, Nancy"' showing total 436 results
Start Over Author "George, Nancy"
436 results on '"George, Nancy"'

1. A framework for developing a knowledge management platform

Author

Mendoza, Marie Lisandra Zepeda, Agarwal, Sonali, Blackshaw, James A., Bol, Vanesa, Fazzi, Audrey, Fiorini, Filippo, Foreman, Amy Louise, George, Nancy, Johnson, Brett R., Martin, Brian, McComb, Dave, Mutasa-Gottgens, Euphemia, Parkinson, Helen, Romacker, Martin, Russell, Rolf, Ségard, Valérien, Tan, Shawn Zheng Kai, Teh, Wei Kheng, Winstanley, F. P., Wong, Benedict, and Smith, Adrian M.

Subjects
Computer Science - Databases
Abstract

Knowledge management (KM) involves collecting, organizing, storing, and disseminating information to improve decision-making, innovation, and performance. Implementing KM at scale has become essential for organizations to effectively leverage vast accessible data. This paper is a compilation of concepts that emerged from KM workshops hosted by EMBL-EBI, attended by SMEs and industry. We provide guidance on envisioning, executing, evaluating, and evolving knowledge management platforms. We emphasize essential considerations such as setting knowledge domain boundaries and measuring success, as well as the importance of making knowledge accessible for downstream applications and non-computational users and highlights necessary personal and organizational skills for success. We stress the importance of collaboration and the need for convergence on shared principles and commitment to provide or seek resources to advance KM. The community is invited to join the journey of KM and contribute to the advancement of the field by applying and improving on the guidelines described., Comment: 18 pages, 1 figure

Published
2024

14. Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly.

Author

Li, Hongjie, Janssens, Jasper, De Waegeneer, Maxime, Kolluru, Sai Saroja, Davie, Kristofer, Gardeux, Vincent, Saelens, Wouter, David, Fabrice PA, Brbić, Maria, Spanier, Katina, Leskovec, Jure, McLaughlin, Colleen N, Xie, Qijing, Jones, Robert C, Brueckner, Katja, Shim, Jiwon, Tattikota, Sudhir Gopal, Schnorrer, Frank, Rust, Katja, Nystul, Todd G, Carvalho-Santos, Zita, Ribeiro, Carlos, Pal, Soumitra, Mahadevaraju, Sharvani, Przytycka, Teresa M, Allen, Aaron M, Goodwin, Stephen F, Berry, Cameron W, Fuller, Margaret T, White-Cooper, Helen, Matunis, Erika L, DiNardo, Stephen, Galenza, Anthony, O'Brien, Lucy Erin, Dow, Julian AT, FCA Consortium§, Jasper, Heinrich, Oliver, Brian, Perrimon, Norbert, Deplancke, Bart, Quake, Stephen R, Luo, Liqun, Aerts, Stein, Agarwal, Devika, Ahmed-Braimah, Yasir, Arbeitman, Michelle, Ariss, Majd M, Augsburger, Jordan, Ayush, Kumar, Baker, Catherine C, Banisch, Torsten, Birker, Katja, Bodmer, Rolf, Bolival, Benjamin, Brantley, Susanna E, Brill, Julie A, Brown, Nora C, Buehner, Norene A, Cai, Xiaoyu Tracy, Cardoso-Figueiredo, Rita, Casares, Fernando, Chang, Amy, Clandinin, Thomas R, Crasta, Sheela, Desplan, Claude, Detweiler, Angela M, Dhakan, Darshan B, Donà, Erika, Engert, Stefanie, Floc'hlay, Swann, George, Nancy, González-Segarra, Amanda J, Groves, Andrew K, Gumbin, Samantha, Guo, Yanmeng, Harris, Devon E, Heifetz, Yael, Holtz, Stephen L, Horns, Felix, Hudry, Bruno, Hung, Ruei-Jiun, Jan, Yuh Nung, Jaszczak, Jacob S, Jefferis, Gregory SXE, Karkanias, Jim, Karr, Timothy L, Katheder, Nadja Sandra, Kezos, James, Kim, Anna A, Kim, Seung K, Kockel, Lutz, Konstantinides, Nikolaos, Kornberg, Thomas B, Krause, Henry M, Labott, Andrew Thomas, Laturney, Meghan, Lehmann, Ruth, Leinwand, Sarah, Li, Jiefu, and Li, Joshua Shing Shun

Subjects
FCA Consortium§, Cell Nucleus, Animals, Drosophila melanogaster, Drosophila Proteins, Transcription Factors, Gene Expression Regulation, Sex Characteristics, Genes, Insect, Databases, Genetic, Female, Male, Gene Regulatory Networks, Single-Cell Analysis, Transcriptome, RNA-Seq, Biotechnology, Genetics, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, General Science & Technology
Abstract

For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula Drosophilae, that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types. We provide an in-depth analysis of cell type-related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whole animal. Analysis of common cell types between tissues, such as blood and muscle cells, reveals rare cell types and tissue-specific subtypes. This atlas provides a valuable resource for the Drosophila community and serves as a reference to study genetic perturbations and disease models at single-cell resolution.

Published
2022

18. Vision, challenges and opportunities for a Plant Cell Atlas

Author

Ahmed, Jahed, Alaba, Oluwafemi, Ameen, Gazala, Arora, Vaishali, Arteaga-Vazquez, Mario A, Arun, Alok, Bailey-Serres, Julia, Bartley, Laura E, Bassel, George W, Bergmann, Dominique C, Bertolini, Edoardo, Bhati, Kaushal Kumar, Blanco-Touriñán, Noel, Briggs, Steven P, Brumos, Javier, Buer, Benjamin, Burlaocot, Adrien, Cervantes-Pérez, Sergio Alan, Chen, Sixue, Contreras-Moreira, Bruno, CORPAS, Francisco J, Cruz-Ramirez, Alfredo, Cuevas-Velazquez, Cesar L, Cuperus, Josh T, David, Lisa I, de Folter, Stefan, Denolf, Peter H, Ding, Pingtao, Dwyer, William P, Evans, Matthew MS, George, Nancy, Handakumbura, Pubudu P, Harrison, Maria J, Haswell, Elizabeth S, Herath, Venura, Jiao, Yuling, Jinkerson, Robert E, John, Uwe, Joshi, Sanjay, Joshi, Abhishek, Joubert, Lydia-Marie, Katam, Ramesh, Kaur, Harmanpreet, Kazachkova, Yana, Raju, Sunil K Kenchanmane, Khan, Mather A, Khangura, Rajdeep, Kumar, Ajay, Kumar, Arun, Kumar, Pankaj, Kumar, Pradeep, Lavania, Dhruv, Lew, Tedrick Thomas Salim, Lewsey, Mathew G, Lin, Chien-Yuan, Liu, Dianyi, Liu, Le, Liu, Tie, Lokdarshi, Ansul, Luong, Ai My, Macaulay, Iain C, Mahmud, Sakil, Mähönen, Ari Pekka, Malukani, Kamal Kumar, Marand, Alexandre P, Martin, Carly A, McWhite, Claire D, Mehta, Devang, Martín, Miguel Miñambres, Mortimer, Jenny C, Nikolov, Lachezar A, Nobori, Tatsuya, Nolan, Trevor M, Ogden, Aaron J, Otegui, Marisa S, Ott, Mark-Christoph, Palma, José M, Paul, Puneet, Rehman, Atique U, Romera-Branchat, Maida, Romero, Luis C, Roth, Ronelle, Sah, Saroj K, Shahan, Rachel, Solanki, Shyam, Song, Bao-Hua, Sozzani, Rosangela, Stacey, Gary, Stepanova, Anna N, Taylor, Nicolas L, Tello-Ruiz, Marcela K, Tran, Tuan M, Tripathi, Rajiv Kumar, Vadde, Batthula Vijaya Lakshmi Vadde, Varga, Tamas, Vidovic, Marija, Walley, Justin W, Wang, Zhiyong, Weizbauer, Renate A, and Whelan, James

Subjects
Plant Biology, Biological Sciences, Agriculture, Chlamydomonas reinhardtii, Chloroplasts, Computational Biology, Image Processing, Computer-Assisted, Plant Cells, Plant Development, Plants, Zea mays, Plant Cell Atlas Consortium, 4D imaging, A. thaliana, Plant Cell Atlas, cell biology, chlamydomonas reinhardtii, location-to-function, maize, science forum, single-cell omics, translational research, Biochemistry and Cell Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

With growing populations and pressing environmental problems, future economies will be increasingly plant-based. Now is the time to reimagine plant science as a critical component of fundamental science, agriculture, environmental stewardship, energy, technology and healthcare. This effort requires a conceptual and technological framework to identify and map all cell types, and to comprehensively annotate the localization and organization of molecules at cellular and tissue levels. This framework, called the Plant Cell Atlas (PCA), will be critical for understanding and engineering plant development, physiology and environmental responses. A workshop was convened to discuss the purpose and utility of such an initiative, resulting in a roadmap that acknowledges the current knowledge gaps and technical challenges, and underscores how the PCA initiative can help to overcome them.

Published
2021

22. Guidelines for reporting single-cell RNA-Seq experiments

Author

Füllgrabe, Anja, George, Nancy, Green, Matthew, Nejad, Parisa, Aronow, Bruce, Clarke, Laura, Fexova, Silvie Korena, Fischer, Clay, Freeberg, Mallory Ann, Huerta, Laura, Morrison, Norman, Scheuermann, Richard H., Taylor, Deanne, Vasilevsky, Nicole, Gehlenborg, Nils, Marioni, John, Teichmann, Sarah, Brazma, Alvis, and Papatheodorou, Irene

Subjects
Quantitative Biology - Genomics
Abstract

Single-cell RNA-Sequencing (scRNA-Seq) has undergone major technological advances in recent years, enabling the conception of various organism-level cell atlassing projects. With increasing numbers of datasets being deposited in public archives, there is a need to address the challenges of enabling the reproducibility of such data sets. Here, we describe guidelines for a minimum set of metadata to sufficiently describe scRNA-Seq experiments, ensuring reproducibility of data analyses.

Published
2019
Full Text
View/download PDF

33. A proteomics sample metadata representation for multiomics integration and big data analysis

Author

Dai, Chengxin, Füllgrabe, Anja, Pfeuffer, Julianus, Solovyeva, Elizaveta M., Deng, Jingwen, Moreno, Pablo, Kamatchinathan, Selvakumar, Kundu, Deepti Jaiswal, George, Nancy, Fexova, Silvie, Grüning, Björn, Föll, Melanie Christine, Griss, Johannes, Vaudel, Marc, Audain, Enrique, Locard-Paulet, Marie, Turewicz, Michael, Eisenacher, Martin, Uszkoreit, Julian, Van Den Bossche, Tim, Schwämmle, Veit, Webel, Henry, Schulze, Stefan, Bouyssié, David, Jayaram, Savita, Duggineni, Vinay Kumar, Samaras, Patroklos, Wilhelm, Mathias, Choi, Meena, Wang, Mingxun, Kohlbacher, Oliver, Brazma, Alvis, Papatheodorou, Irene, Bandeira, Nuno, Deutsch, Eric W., Vizcaíno, Juan Antonio, Bai, Mingze, Sachsenberg, Timo, Levitsky, Lev I., and Perez-Riverol, Yasset

Published
2021
Full Text
View/download PDF

35. Investigating the mechanism of cell competition in mESCs

Author

George, Nancy and Rodriguez, Tristan

Subjects
610
Abstract

Cell competition is a type of cell-cell interaction first described in Drosophila by Morato and Ripoll (1976), whereupon the co-existence of two cell populations with different metabolic properties or growth rates results in the growth of the stronger population at the expensive of the weaker one. BMP2 and 4 are the Drosophila homologues of Decapentaplegic which has been shown to have roles in cell competition. Based on data from studies on Drosophila models of cell competition, the lab generated mESCs null for Bmpr1a and investigated their behaviour when co-cultured with wild-type mESCs as a mammalian model of cell competition. This report further investigates changes in proliferation and apoptosis among competing cells and begins to investigate the signalling pathways which drive loser cells to initiate apoptosis. We report that apoptosis is caspase-dependent and possibly mediated by ERK and Wnt signalling as modulating these pathways changes the dynamics of competing cells. The report utilises a transwell growth system to demonstrate that cell competition is mediated by unknown signalling factors, an observation which has also been described in models of competing cells in Drosophila. The report shows that differentiation of mESCs is an important inducing factor for cell competition as naïve mESCs do not compete. Lastly this study shows that cell competition is a general mechanism of maintaining stem cell quality as other mutations which incur a growth or metabolic disadvantage as mESCs with defects in autophagy or are tetraploid are also eliminated by cell competition when co-cultured with wild-type cells.

Published
2014
Full Text
View/download PDF

36. Purification of ursolic acid and β-sitosterol from endophytic Alternaria alternatafor their alpha-amylase inhibitory activity

Author

Dwibedi, Vagish, Mishra, Shashank Shekher, George, Nancy, Joshi, Mahavir, Kaur, Gursharan, Gupta, Mukul, and Rath, Santosh Kumar

Abstract

AbstractFungal endophytes are a known warehouse of bioactive compounds with multifarious applications. In the present investigation two compounds, β-Sitosterol (1) and ursolic acid (2), were isolated from Alternaria alternata, an endophytic fungus associated with Morus albaLinn for the first time. The structure of the compounds was elucidated on the basis of comprehensive spectral analysis (UV, IR, 1 H-, 13 C- and 2D-NMR, as well as HRESI–MS). In the in vitroalpha amylase inhibitory assay both compounds (1) and (2) show potent antidiabetic activity. In support, Docking studies indicate significant binding affinity of the isolated compounds. Hence from the present study, it can be concluded that endophytic fungi in Morus albaLinn can find use in antidiabetic drug development in the medicinal industry.Communicated by Ramaswamy H. Sarma

Published
2024
Full Text
View/download PDF

37. Teaching Evidence-Based Practice to MSN, DNP and PhD students: Lessons Learned.

Author

McNeill, Cynthera, George, Nancy, Stephens, Umeika, and Walker, Tara

Subjects
*EVIDENCE-based nursing, *CURRICULUM, *QUALITATIVE research, *DIFFUSION of innovations, *GRADUATE students, *DOCTORAL students, *EDUCATIONAL outcomes, *QUESTIONNAIRES, *NURSING education, *TEACHING methods, *QUANTITATIVE research, *DESCRIPTIVE statistics, *PRE-tests & post-tests, *LABOR demand, *LEARNING strategies, *STUDENT attitudes, *NURSING students
Abstract

Background: An evidence-based practice (EBP) course containing Master of Nursing (MSN), Doctor of Nursing Practice (DNP) and Doctor of Philosophy (PhD) nursing students (N=76) was offered during a 12-week Spring/Summer semester. The intent of this evaluation is to assess the effectiveness and feasibility of a combined graduate level EBP course. Method: A pre-posttest design was used. Anonymous, de-identified demographic questions and the Student Evidence Based Practice Questionnaire (SEBPQ) were used for data collection. Results: The results indicated a significant difference pre vs post course in the areas of EBP use (Sig <0.001; F 15.806), EBP Skill (Sig <0.001, F 43.250) and EBP Communication (Sig <0.001; F 27.566). However, 22 out of the 24 students that reported feeling overwhelmed by the course were MSN students (91.7%). Conclusion: The facilitation, evaluation, and redesign of EBP curriculum need to be informed by data gathered from formal assessments. [ABSTRACT FROM AUTHOR]

Published
2024

38. Expression Atlas update: insights from sequencing data at both bulk and single cell level

Author

George, Nancy, primary, Fexova, Silvie, additional, Fuentes, Alfonso Munoz, additional, Madrigal, Pedro, additional, Bi, Yalan, additional, Iqbal, Haider, additional, Kumbham, Upendra, additional, Nolte, Nadja Francesca, additional, Zhao, Lingyun, additional, Thanki, Anil S, additional, Yu, Iris D, additional, Marugan Calles, Jose C, additional, Erdos, Karoly, additional, Vilmovsky, Liora, additional, Kurri, Sandeep R, additional, Vathrakokoili-Pournara, Anna, additional, Osumi-Sutherland, David, additional, Prakash, Ananth, additional, Wang, Shengbo, additional, Tello-Ruiz, Marcela K, additional, Kumari, Sunita, additional, Ware, Doreen, additional, Goutte-Gattat, Damien, additional, Hu, Yanhui, additional, Brown, Nick, additional, Perrimon, Norbert, additional, Vizcaíno, Juan Antonio, additional, Burdett, Tony, additional, Teichmann, Sarah, additional, Brazma, Alvis, additional, and Papatheodorou, Irene, additional

Published
2023
Full Text
View/download PDF

40. PSII-6 Computational Tools and Resources for Analysis and Exploration of Single-Cell Rnaseq Data in Agriculture

Author

Kapoor, Muskan, primary, Tuggle, Christopher K, additional, Burdett, Tony, additional, Tickle, Timothy, additional, Harrison, Peter, additional, Elsik, Christine, additional, Provart, Nicholas, additional, Libault, Marc, additional, Warren, Wes, additional, Koltes, James E, additional, Sokolov, Alexey, additional, Ventura, Enrique Sapena, additional, Yordanova, Galabina, additional, Papatheodorou, Irene, additional, George, Nancy, additional, Ware, Doreen, additional, Kumari, Sunita, additional, Daharsh, Lance, additional, and Cole, Benjamin, additional

Published
2023
Full Text
View/download PDF

41. Systems and Strategies at the University of Technology, Jamaica to Strengthen the Education/Industry Interface.

Author

Al-Zubaidy, Sarim and George, Nancy A.

Abstract

Since 1995, when the College of Arts, Science, and Technology (CAST) became the University of Technology, Jamaica (UTech), it has been working to integrate the best features of CAST's polytechnic tradition with the academic and research culture necessary in a university. Central to CAST's success has been its partnerships with business and industry. UTech is in the process of refining and strengthening the Program Advisory Committee system, the workplace training component of its undergraduate programs, its linkages with other training institutions (both technical and vocational education and training and tertiary) and like-minded external institutions. To these existing institutions, UTech is adding the Jamaica Teaching Company Scheme and a Technology Innovation Center, a business incubator for Jamaica. As the UTech undergoes this cultural transition, it is faced with myriad challenges, such as gaining the trust of industry, assisting staff inherited from CAST in making the cultural leap to UTech, creating the kind of environment in which people want to perform outstandingly, and helping students caught in the transition gain rather than lose in the process. (YLB)

Published
2000

42. Guidelines for reporting single-cell RNA-seq experiments

Author

Füllgrabe, Anja, George, Nancy, Green, Matthew, Nejad, Parisa, Aronow, Bruce, Fexova, Silvie Korena, Fischer, Clay, Freeberg, Mallory Ann, Huerta, Laura, Morrison, Norman, Scheuermann, Richard H., Taylor, Deanne, Vasilevsky, Nicole, Clarke, Laura, Gehlenborg, Nils, Kent, Jim, Marioni, John, Teichmann, Sarah, Brazma, Alvis, and Papatheodorou, Irene

Published
2020
Full Text
View/download PDF

46. Optical detection of heavy metal contaminants: advancements with bio-functionalized gold nanoparticles in environmental monitoring.

Author

Gupta, Subhi, George, Nancy, Yadav, Mohini, and Dwibedi, Vagish

Abstract

Heavy metal pollution has toxic repercussions on humans as well as on the environment, and these metals when retained in the environment significantly alter the biological and ecological cycles. The need of the hour is to design an approach for targeted sensing of heavy metal ions present in water bodies. The unique plasmonic and optical properties of gold nanoparticles serve as a foundation for the development of sensitive, selective, and analytical AuNP-based biosensing instruments. Modification/functionalization of AuNPs with different biomolecules such as DNA/DNAzymes, oligonucleotides, aptamers, and peptides serves as linking and capping agents for AuNPs. Functionalization with biomolecules offers biocompatibility, stability, enhanced catalytic activity, low toxicity, and selective binding and sensing to AuNPs. These biomolecules demonstrate distinct recognition skills and unique binding affinities with AuNPs. Bio-functionalized AuNP-based sensors have lately intrigued a significant research interest since they offer a practical use in environmental remediation through the sensing of harmful metal ions along with other pollutants. This review focuses on the new advancements in the development of nano-biosensors based on bio-based surface-functionalized AuNPs as probes, employed in heavy metal ions sensing. The mechanism of functionalization of AuNPs and the development of various optical sensors using bio-functionalized AuNPs have been discussed in depth. Finally, we have discussed the research priorities in this field that will help researchers for further investigations to develop promising future tools serving as "lab-on-chip" sensing devices. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

47. Expression Atlas update: insights from sequencing data at both bulk and single cell level.

Author

George, Nancy, Fexova, Silvie, Fuentes, Alfonso Munoz, Madrigal, Pedro, Bi, Yalan, Iqbal, Haider, Kumbham, Upendra, Nolte, Nadja Francesca, Zhao, Lingyun, Thanki, Anil S, Yu, Iris D, Marugan Calles, Jose C, Erdos, Karoly, Vilmovsky, Liora, Kurri, Sandeep R, Vathrakokoili-Pournara, Anna, Osumi-Sutherland, David, Prakash, Ananth, Wang, Shengbo, and Tello-Ruiz, Marcela K

Published
2024
Full Text
View/download PDF

48. User-friendly, scalable tools and workflows for single-cell RNA-seq analysis

Author

Moreno, Pablo, Huang, Ni, Manning, Jonathan R., Mohammed, Suhaib, Solovyev, Andrey, Polanski, Krzysztof, Bacon, Wendi, Chazarra, Ruben, Talavera-López, Carlos, Doyle, Maria A., Marnier, Guilhem, Grüning, Björn, Rasche, Helena, George, Nancy, Fexova, Silvie Korena, Alibi, Mohamed, Miao, Zhichao, Perez-Riverol, Yasset, Haeussler, Maximilian, Brazma, Alvis, Teichmann, Sarah, Meyer, Kerstin B., and Papatheodorou, Irene

Published
2021
Full Text
View/download PDF

50. Nystart eller omstart? : Vilken information får ämneslärare i svenska om läs- och skrivsvårigheter, när de tar emot elever från åk 6?

Author

George, Nancy, Sneitz, Ulrika, George, Nancy, and Sneitz, Ulrika

Abstract

Syftet i denna kvalitativa studie är att undersöka hur elever med läs- och skrivsvårigheter beskrivs i samband med överlämningen till årskurs 7. Vi valde en tematisk metod för att analysera intervjudata. En teoriansats utifrån Bronfenbrenners ekologiska utvecklingsmodell har använts för att titta på hela den sociala interaktionen som äger rum runt ett barn. Sex ämneslärare i svenska, tre speciallärare och två specialpedagoger intervjuades. Resultatet visar att det är viktigt att det finns rutiner i samband med elevers övergångar och att samarbetet mellan överlämnande och mottagande skola är välfungerande. Tidiga stödinsatser är en förutsättning för att elever med läs- och skrivsvårigheter ska lyckas. Informanterna lyfter även fram att det finns ett behov av informativa ämnesbeskrivningar, det vill säga information om elevernas kunskapsutveckling. Ämneslärare i svenska föredrar att inte få förhandsinformation om elever medan speciallärare och specialpedagoger anser att förhandsinformationen är mycket viktig för att kunna ge stöd till elever med behov. Slutsatsen som dras från denna studie är baserad på våra egna tolkningar utifrån insamlat material.

Published
2023

Catalog

Books, media, physical & digital resources
See catalog results