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Alzheimer's disease (AD) is a progressive neurodegenerative disease that still has no permanent cure. The drugs prescribed in the present days are only for symptomatic relief for the patients. Many studies correlating the reduction in the incidence of AD with the diet consumed have been published. These studies showed that a diet rich in polyphenols is associated with a decrease in the incidence of AD. The present review is focused on the ability of pomegranate and its bioactive components to ameliorate the progression of AD and their ability to exert a neuroprotective effect. Various studies showing the ability of pomegranate in inhibiting enzymes, reducing reactive oxygen species, inhibition of microglial activation, inhibition of tau protein hyperphosphorylation, maintenance of synaptic plasticity, anti-inflammatory activity and its ability to inhibit Beta secretase-1 (BACE-1) has been reviewed in this article. In spite of the lack of studies on humans, there are compelling evidence indicating that pomegranate can reduce various risk factors involved in the causation of AD and thus can be used as a persistent nutraceutical to slow ageing and for providing neuroprotection for the treatment of AD. Highlights An overview of traditional and pharmacological uses of pomegranate (POM). Potential of POM in the treatment of neurodegenerative diseases especially in AD. Insight into the molecular mechanisms of neuroprotective effects of POM in AD. Clinical evaluation studies involving POM and its bioactive components. [ABSTRACT FROM AUTHOR]

Current research work deals with the design, synthesis and in vitro analysis of some novel 3,4-dihydropyrimidin-2-one derivatives for breast carcinoma. Different analytical methods like UV, FTIR, 1H NMR, 13C NMR and Mass spectrometry were performed to obtain the data regarding the structure of the nine synthesized derivatives. The derivatives designed were then subjected to in silico docking studies using BIOVIA Discovery Studio using the receptor Histone deacetylase protein (5EDU). ADMET analysis and Lipinski rule were performed using Biovia Discovery studio and molinspiration. All the compounds showed good interaction with HDAC protein Compounds were synthesized using three component one pot synthesis. IR spectroscopy of the derivatives showed alkane -CH str, aromatic C=C str, aromatic -CH str, -NH str, C=O str and C-N str in common. No additional peak were found in the spectrum. Number of protons and carbon atoms were confirmed by 1H NMR and 13C NMR and mass spectrometry. The derivatives were then screened for their antioxidant property by using DPPH assay. All the compounds showed moderate antioxidant activity when compared with the standard ascorbic acid. CS8 showed best antioxidant property. The cytotoxicity studies of the derivatives were tested in vitro by using 4T1 cell lines by Alamar blue assay method.CS3 and CS8 derivatives were found to be more effective. From the Cell line studies it have been concluded that the synthesized derivatives CS3 and CS8 inhibited the proliferation of 4T1 breast cancer cell lines at 180 and 360µg/mL at 48th hour. All derivatives synthesized proved to be cancer specific. [ABSTRACT FROM AUTHOR]