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5. Short, medium, and long deferral of umbilical cord clamping compared with umbilical cord milking and immediate clamping at preterm birth: a systematic review and network meta-analysis with individual participant data

Author

Seidler, Anna Lene, Libesman, Sol, Hunter, Kylie E, Barba, Angie, Aberoumand, Mason, Williams, Jonathan G, Shrestha, Nipun, Aagerup, Jannik, Sotiropoulos, James X, Montgomery, Alan A, Gyte, Gillian M L, Tarnow-Mordi, William O, El-Naggar, Walid, Carlo, Waldemar A, Datta, Vikram, Lago, Victor, Sundaram, Venkataseshan, Manoj, Varanattu C, Debray, Thomas P A, Sahoo, Tanushree, Trongkamonthum, Tanai, Hooper, Stuart B, Dias, Sofia, Pratesi, Simone, Badurdeen, Shiraz, Hosono, Shigeharu, Belk, Sheila S, Shekhar, Shashank, Chamnanvanakij, Sangkae, Arsan, Saadet, Knol, Ronny, Simes, Robert John, Riley, Richard D, Pongmee, Pharuhad, Davis, Peter G, Andersson, Ola, Dipak, Niraj K, Nasef, Nehad, Allam, Nahed E, Mangla, Mukul K, Meyer, Michael P, March, Melissa I, Kluckow, Martin, Goya, Maria, de Veciana, Margarita, Gharehbaghi, Manizheh M, Robledo, Kristy P, Murphy, Kellie E, Wallace, Kedra, Fairchild, Karen D, Josephsen, Justin B, Mercer, Judith S, Dorling, Jon S, Kattwinkel, John, Liu, Jiang-Qin, Nour, Islam, Atia, Hytham, Liley, Helen G, Rabe, Heike, Al-Wassia, Heidi K, Carroli, Guillermo, Polglase, Graeme R, Ram Mohan, Govindu, Dempsey, Eugene M, Okulu, Emel, Blank, Douglas A, Chawla, Deepak, Ruangkit, Chayatat, Tanprasertkul, Chamnan, De Paco Matallana, Catalina, Backes, Carl H, Schwaberger, Bernhard, Urlesberger, Berndt, KC, Ashish, te Pas, Arjan B, Katheria, Anup C, Thukral, Anu, George, Anu A, Webster, Angela C, Kugelman, Amir, Tan, Aidan C, Kumar, Aditi, Garg, Aashim, Duley, Lelia, and Askie, Lisa M

Published
2023
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6. Deferred cord clamping, cord milking, and immediate cord clamping at preterm birth: a systematic review and individual participant data meta-analysis

Author

Seidler, Anna Lene, Aberoumand, Mason, Hunter, Kylie E, Barba, Angie, Libesman, Sol, Williams, Jonathan G, Shrestha, Nipun, Aagerup, Jannik, Sotiropoulos, James X, Montgomery, Alan A, Gyte, Gillian M L, Garg, Aashim, Kumar, Aditi, Tan, Aidan C, Kugelman, Amir, Webster, Angela C, George, Anu A, Thukral, Anu, Katheria, Anup C, te Pas, Arjan B, KC, Ashish, Urlesberger, Berndt, Schwaberger, Bernhard, Backes, Carl H, De Paco Matallana, Catalina, Tanprasertkul, Chamnan, Ruangkit, Chayatat, Chawla, Deepak, Blank, Douglas A, Okulu, Emel, Dempsey, Eugene M, Ram Mohan, Govindu, Polglase, Graeme R, Carroli, Guillermo, Al-Wassia, Heidi K, Rabe, Heike, Liley, Helen G, Atia, Hytham, Nour, Islam, Liu, Jiang-Qin, Kattwinkel, John, Dorling, Jon S, Mercer, Judith S, Josephsen, Justin B, Fairchild, Karen D, Wallace, Kedra, Murphy, Kellie E, Robledo, Kristy P, Gharehbaghi, Manizheh M, de Veciana, Margarita, Goya, Maria, Kluckow, Martin, March, Melissa I, Meyer, Michael P, Mangla, Mukul K, Allam, Nahed E, Nasef, Nehad, Dipak, Niraj K, Andersson, Ola, Davis, Peter G, Pongmee, Pharuhad, Riley, Richard D, Simes, Robert John, Knol, Ronny, Arsan, Saadet, Shekhar, Shashank, Belk, Sheila S, Hosono, Shigeharu, Badurdeen, Shiraz, Pratesi, Simone, Dias, Sofia, Hooper, Stuart B, Sahoo, Tanushree, Debray, Thomas P A, Manoj, Varanattu C, Sundaram, Venkataseshan, Lago, Victor, Datta, Vikram, El-Naggar, Walid, Carlo, Waldemar A, Tarnow-Mordi, William O, Duley, Lelia, and Askie, Lisa M

Published
2023
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12. A novel enhanced gain boost converter with low voltage stress.

Author

Joy, Jinsa K., Joy, Ninu, James, Geethu, George, Anu, Joy, Jeena, and Neema, S

Abstract

In recent times, the demand for high gain DC-DC converters is on the rise in various sectors, including portable electronics, energy reserve, telecommunications and ups. The primary source of renewable energy is photovoltaic (PV) systems; however, they typically produce a low output voltage, necessitating the use of high DC voltage for various applications. Achieving high gain using a conventional boost converter operating at a high duty ratio will lead to higher voltage stress and low efficiency. The proposed converter has been engineered to attain significant gain while employing a lower duty ratio and minimizing voltage stress. This configuration is obtained through the adaptation of the conventional switched inductor boost converter (SIBC). It involves the substitution of one diode with a control switch and the addition of a voltage multiplier cell at the rear end, effectively reducing the voltage stress experienced by the switches and thereby decreasing their voltage ratings. Furthermore, the converter exhibits zero source transient current and has a positive output voltage polarity along with common ground. After conducting a detailed analysis of the steady state characteristics and operation of the converter the results have been generated through simulation using MATLAB/Simulink R2017b. Based on the simulation findings, the converter exhibits notable voltage amplification and achieves a peak efficiency of 85%. The hardware prototype with an input of 5V is then implemented using a TMS320F28027F microcontroller and an output of 72V is obtained. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

Author

Yañez, Anahí, Fernández, Marcelo, Tolcachier, Alberto, Belloni, Juan, Taborda, Jorge, De Salvo, Maria, Maspero, Jorge, Victorio, Carlos, Navarta, Miguel Chirino, Grilli, Monica, Rodríguez, Pablo, Otaola, María, Cambursano, Víctor, Malamud, Patricia, Stok, Ana, Arce, German, Roza, Osiris, Scherbovsky, Fernando, Elias, Pedro, Saez, Maria Salazan, Peters, Matthew, Phillips, Martin, Upham, John, Gibson, Peter, Thien, Francis, Douglass, Jo, Thomas, Paul, Bardin, Philip, Sajkov, Dimitar, Hew, Mark, Langton, David, Pez, Andreia, Fritscher, Carlos, Hetzel, Jorge, Mattos, Waldo, Stelmach, Rafael, Antila, Martti, Fernandes, Ana Luisa, Metev, Hristo, Ivanov, Yavor, Bogdanova, Aneliya, Markova, Ana Dancheva, Peneva, Marinka, Veselinova, Rumyana, Petkova, Tatyana, Petrova, Vanushka, Shopova, Elena, Ivanova, Yuliya, Yotsova, Rumyana, Kirkova, Ginka, Petrova, Galina, Dachev, Svetoslav, Sotirova, Kostadinka, Stoyanova, Mariyana, Yakov, Oleg, Ilieva-Fartunova, Vanya, Lemiere, Catherine, Laviolette, Michel, Yang, William, FitzGerald, J Mark, Pek, Bonavuth, Killorn, William Patrick, Poirier, Claude, Chouinard, Guy, Melenka, Lyle, Leigh, Richard, Nair, Parameswaran, Dorscheid, Delbert, Martin, James, Pavie, Juana, Rosenblut, Andres, Cartagena, Claudia, Quilodran, Carlos, Muñoz, Silvia, Malkusova, Ivana, Veverka, Josef, Holub, Stanislav, Mares, Jaroslav, Kozel, Radovan, Kopecka, Daniela, Zindr, Vladimir, Cerva, Pavel, Chanez, Pascal, Bourdin, Arnaud, Devouassoux, Gilles, Taille, Camille, De Blay, Frédéric, Goupil, Francois, Leroyer, Christophe, Gourcerol, Delphine, Didi, Toufik, Didier, Alain, Garcia, Gilles, Bonniaud, Philippe, Vasram, Riazate Rossanaly, Lommatzsch, Marek, Harnest, Ulf, Linnhoff, Anneliese, Keller, Claus, Hoheisel, Gerhard, Förster, Karin, Schultz, Thomas, Schenkenberger, Isabelle, Kirschner, Joachim, Schmoller, Tibor, Zielen, Stefan, Kornmann, Marc, Beck, Ekkehard, Volgmann, Lutz, Dichmann, Rolf, Overlack, Axel, Winkler, Jörg, Mikloweit, Petra, Ballenberger, Sabine, Rolke, Mathias, Korn, Stephanie, Pabel, Helmut, Hoffmann, Martin, Feimer, Jan, Rabe, Klaus, Deckelmann, Regina, Welte, Tobias, Ohbayashi, Hiroyuki, Hozawa, Soichiro, Shimoda, Terufumi, Yoshida, Makoto, Nagakura, Toshikazu, Kamei, Tadashi, Sano, Yasuyuki, Kagami, Shinichiro, Takahashi, Hisaho, Haida, Michiko, Kimura, Goro, Nakamura, Hiroyuki, To, Yasuo, Shinkai, Masaharu, Shimokawaji, Tadasuke, Kudo, Makoto, Shijyubo, Noriharu, Tochigi, Takao, Kato, Motokazu, Tanaka, Akihiko, Gon, Yasuhiro, Sasaki, Norihisa, Ohdaira, Tetsuro, Omori, Chiharu, Takahashi, Toshiki, Takeuchi, Satomi, Nakajima, Kiyotaka, Makita, Hironi, Kaneko, Masahiro, Furuta, Kenjiro, Taniguchi, Masami, Inobe, Yoshito, Miki, Hiroshi, Nakamura, Yoichi, Miyazawa, Naoki, Yano, Shuichi, Iijima, Masayuki, Yamato, Tsuyoshi, Diaz, Javier, Matsuno, Alberto, Felix, Efrain, Guerreros, Alfredo, Daly, Alejandro, Rodriguez Chariarse, Fernando, Salazar, Danilo, Castro, Socorro, Chavez, William, Estrella, Rolando, Aquino, Teresita, Atienza, Tito, Samoro, Ronnie, Isidro, Marie Grace Dawn, Kuna, Piotr, Antczak, Adam, Bednarek, Michał, Mądra-Rogacka, Danuta, Hofman, Teresa, Jutel, Marek, Pisarczyk-Bogacka, Ewa, Kot, Agata, Mróz, Robert, Czupryńska-Borkowska, Małgorzata, Żurowska-Gębala, Małgorzata, Dyczek, Andrzej, Jasieniak-Pinis, Grażyna, Wojnowski, Piotr, Trębas-Pietraś, Ewa, Dobryniewska, Małgorzata, Stobiecki, Marcin, Tarnowska-Matusiak, Marzenna, Magner, Alina, Kolczyński, Andrzej, Kachel, Tomasz, Bartuzi, Zbigniew, Majorek-Olechowska, Bernadetta, Śliwiński, Paweł, Balicka, Violetta, Hajoł, Elżbieta, Stachera, Jacek, Rachel, Marta, Michnar, Marek, Tałałaj, Jarosław, Springer, Ewa, Napora, Piotr, Grzelewski, Tomasz, Bijata-Bronisz, Renata, Świderska, Anna, Mincewicz, Grzegorz, Sankowski, Zbigniew, Fijołek, Tomasz, Kwaśniewski, Artur, Jerzyńska, Joanna, Cygler, Jerzy, Olesiejuk, Ryszard, Von Steiner, Iwona, Machowiak, Wojciech, Filipek, Krzysztof, Piskorz, Piotr, Uhryn, Ewa, Nittner-Marszalska, Marita, Rybicka-Liszewska, Elżbieta, Bodzenta-Łukaszyk, Anna, Chełmińska, Marta, Krupa-Borek, Izabella, Skucha, Wojciech, Płoszczuk, Anna, Mihaescu, Traian, Petrui, Ioan Dorin, Savu, Angelica, Apti, Ghiulten, Toma, Claudia, Trailescu, Ana, Sokurenko, Sergei, Trofimov, Vasiliy, Leshchenko, Igor, Shaporova, Natalia, Ilyashevich, Inna, Stitsenko, Irina, Vizel, Alexander, Ilkovich, Yulia, Tikhanov, Dmitrii, Goncharova, Svetlana, Ezhov, Andrey, Ignatova, Galina, Izmozherova, Nadezhda, Berdnikova, Nadezhda, Goryachkina, Ludmila, Popova, Veronika, Bolieva, Laura, Rebrov, Andrey, Nosov, Vladimir, Magnitskaya, Olga, Nedogoda, Sergey, Abrosimov, Vladimir, Molotkov, Artem, Reshedko, Galina, Smirnov, Mikhail, Osipenko, Marina, Pavlysh, Elena, Myasoedova, Svetlana, Lenskaya, Liudmila, Chistyakov, Valery, Vishneva, Elena, Uon, Liliya, Zateyschikova, Anna, Laleko, Svetlana, Pak, Tatiana, Bruning, Axel, Naidoo, Visvakuren, Reddy, Jeevren, Van Zyl Smit, Richard, Park, Hae-Sim, Cho, Young Joo, Cho, Sang-Heon, Lee, Sang Haak, Lee, Byung Jae, Kim, Ju Sang, Cho, You Sook, Park, Choon-Sik, Kim, Mi-Kyeong, Koh, Young-Il, Kim, Joo-Hee, Lee, Sook Young, Lee, Sang Pyo, Park, Jung Won, Yoo, Kwang Ha, Yoon, Hyoungkyu, Lee, Jaechun, Hur, Gyu-Young, Lee, Soo Keol, Kim, HeeKyoo, Ramos Barbón, David, Laffond Yges, Elena, Martínez Moragón, Eva, Arias Guillen, Miguel, Saura Vinuesa, Alberto, Sánchez-Toril López, Fernando, Velasco Garrido, José Luis, García-Cosio Piqueras, Borja, Pérez de Llano, Luis, Valero Santiago, Antonio Luis, Rubio, Myriam Calle, Bjermer, Leif, Lundbäck, Bo, Gemicioglu, Bilun, Bavbek, Sevim, Ediger, Dane, Erdinc, Munevver, Hanta, Ismail, Nayci, Sibel, Arinc, Sibel, Iashyna, Liudmyla, Mostovoy, Yuriy, Ostrovskyy, Mykola, Kuryk, Lesia, Lemko, Ivan, Ospanova, Tetyana, Moskalenko, Liubov, Korzh, Oleksii, Blazhko, Viktor, Krakhmalova, Olena, Romaniuk, Liliia, Dytyatkovs'ka, Yevgeniya, Yakovenko, Oleh, Gavrysyuk, Volodymyr, Burhan, Hassan, Saralaya, Dinesh, Scott, Stephen, Morice, Alyn, Jackson-Voyzey, Ewart, Win, Thida, Nasser, Shuab, Harrison, Richard, Chaudhuri, Rekha, Nordstrom, Monica, De, Pradip, Masoli, Matthew, Mansur, Adel, Gunstone, Anthony, Niven, Robert, Harrison, Timothy, Babu, Suresh, Bhuchar, Subodh, Kureishy, Shahrukh, Zwetchkenbaum, John, Kaplan, Lawrence, Bleecker, Eugene, Reyes, Santiago, Fakih, Faisal, Heuer, Marvin, Klein, Ryan, Marcus, Michael, Hussain, Iftikhar, Tanus, Tonny, Raissy, Hengameh, Alpizar, Sady, Rodriguez, Hector, Gleich, Gerald, Bridges, Tracy, Pouzar, Joe, Steven, Gary, Matz, Jonathan, Krstevska, Shana, Ziworitin, Dama, Kaplan, Adolfo, Sublett, James, DeAngelo, James, Darter, Amy, Agaiby, John, Hagan, John, Davis, Enrique, Siri, Dareen, Mcevoy, Charlene, Dharma, Chrisette, Karimjee, Najmuddin, Kelsen, Steven, Frade, Manuel, Silverthorn, Amy, Kline, Joel, Averill, Francis, Ruiz, Jose, Robinette, Emory, Shaikh, Zeeshan, Aguilar, Carlos, Nish, William, Alvarez, German, Ismail, Younus, Parikh, Purvi, Leong, Mila, Murphy, Dennis, Garcia, Francisco, Goldsobel, Alan, Blanco, Antonio, Campbell, Edward, Perez, Guido, Chupp, Geoffrey, Bates, Toby, Perez, Vandely, Wenzel, Sally, Shenoy, Kartik, Katial, Rohit, Bernstein, David, Parikh, Neil, Sims, William, Ferguson, Gary, Pham, David, George, Anu, Beasley, Richard, Perez, Gilberto, Garver, Robert, Garcia-Portela, Miriam, Wong, Stephen, Soong, Weily, Guillot, Richard, Hudes, Golda, Arif, Ahmed, Binker, Josefa, Villareal, Manuel, Ziegner, Ulrike, Ojile, Joseph, Goswami, Sanjeev, Piniella, Carlos, Segal, Ilia, Zafra, Heidi, Lee, Mitchell, Tarpay, Martha, Panuto, John, Merchant, Rajan, Springsteen, Peter, Scialla, Timothy, Shapero, Paul, Allen, Karen, Moss, Mark, Cruz, Humberto, Rumbyrt, Jeffrey, Boyd, Amy, Nathan, Robert, Bernstein, Jonathan, Jacobs, Joshua, Ginchansky, Elliot, Johnston, Janice, Baxter, Barbara, Johnson II, Thomas, Apaliski, Stephen, Corder, Clinton, Fuentes, David, Diaz, Joseph, Ngo, Chau, Le, Lan, Busse, William W, Bleecker, Eugene R, Ferguson, Gary T, Barker, Peter, Sproule, Stephanie, Olsson, Richard F, Martin, Ubaldo J, and Goldman, Mitchell

Published
2019
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21. A Novel Large Deletion in the EVER1Gene in a Family With Epidermodysplasia Verruciformis From India

Author

Godfred, Adithya Christopher, Thomas, Zachariah, Peter, Dincy, Joseph, Anjana, Ravichandran, Lavanya, George, Anu Anna, Pulimood, Susanne A., Gaikwad, Pranay, Babu, Ramesh, Thomas, Meera, Thomas, Nihal, and Chapla, Aaron

Abstract

Epidermodysplasia verruciformis (EV) is a rare autosomal recessive genodermatosis due to mutations in EVER1and EVER2genes. The genetic profile of Indian patients with EV has not been previously studied. This report describes the clinical presentation and molecular analysis of a family with EV. Using genomic DNA from two affected probands and healthy controls (two other siblings), conventional polymerase chain reaction (PCR) was conducted with novel primer sets designed to amplify the coding and splice-site regions in the genes EVER1and EVER 2. This revealed no amplification with a primer set for exons 16 to 18 in the EVER1gene of both the probands. Subsequently, long-range PCR spanning the length of exon 15–20 and next-generation sequencing demonstrated a homozygous deletion of 2078 bp in the EVER1gene (EVER1:c.2072_2278del). Screening the family revealed the same homozygous deletion (similar to index cases) in two other affected siblings. The parents and two asymptomatic siblings were heterozygous carriers for the deletion while one healthy sibling was negative. These results were validated with Sanger sequencing. This deletion in exons 17 and 18 of the EVER1gene results in a frameshift, followed by a premature termination resulting in a severe phenotype. The identification and validation of this large deletion was detected using stepwise amplicon-based target enrichment and long-range PCR, respectively. In this family, this simple strategy greatly enhanced genetic counseling as well as early genetic diagnosis and screening. However, functional assays and larger studies are required to characterize and validate the genetic diversity among Indians with EV.

Published
2024
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22. Socio-demographic profile and pattern of meat consumption of the consumers of Thrissur corporation.

Author

Chandran, Aswathy, George, Anu, Jiji, R. S., George, P. Reeja, and Gleeja, V. L.

Subjects
MEAT industry, CONSUMERS, FAMILY size, MEAT quality
Abstract

The present study analysed the socio-demographic profile and the pattern of consumption of meat among consumers in the Thrissur Corporation area of Kerala state, India. A survey research design using a pretested structured schedule was employed among a sample of 150 meat consumers. The results revealed that majority of the respondents were female (65.30 per cent) and belonged to middle age group of 30-50 years (51.3 per cent). More than three-fourth of the consumers had a family size of up to four members (78 per cent). The annual income of majority of the respondents was within the range of one to ten lakh (66.70 per cent) and nearly 40.70 per cent of consumers were graduates. The results of this study indicated that all the respondents preferred to consume chicken when compared to chevon (39.3 per cent), beef (72.6 per cent), pork (37.3 per cent), or rabbit meat (4.7 per cent). Majority of the consumers consumed meat once or twice a week (73.3 per cent) and all the respondents assessed the quality of meat based on its colour. Most of them preferred to purchase meat from the local meat stalls (97.3per cent). Consumers reported that the reason for their preferred place of purchase was the availability of quality and fresh meat. [ABSTRACT FROM AUTHOR]

Published
2024
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23. 724. Prevalence and Risk Factors for Carbapenem Resistant Enterobacterales Colonization on Admission to Two Intensive Care Units in India

Author

Mansoor, Armaghan-e-Rehman, primary, Edathadathil, Fabia, additional, Suresh, Devendhu, additional, Krishna, Yathu, additional, George, Anu, additional, van Rheenen, Jacaranda, additional, Sinclair, Dorothy, additional, Olsen, Margaret A, additional, Vasudevan, Anil K, additional, Kwon, Jennie H, additional, Leekha, Surbhi, additional, Singh, Sanjeev, additional, Warren, David K, additional, and Gandra, Sumanth, additional

Published
2023
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30. Dermoscopy in cutaneous amyloidosis. - A prospective study from India

Author

Peter, C. Dincy, Agarwala, Manoj, George, Leni, Balakrishnan, Nirmal, George, Anu, and Mahabal, Gauri

Subjects
Medical research, Medicine, Experimental, Skin -- Research, Amyloidosis -- Research, Health
Abstract

Byline: C. Dincy Peter, Manoj. Agarwala, Leni. George, Nirmal. Balakrishnan, Anu. George, Gauri. Mahabal Sir, Primary cutaneous amyloidosis includes macular amyloidosis (MA), lichen amyloidosis (LA), and biphasic amyloidosis. A presumptive [...]

Published
2022

32. Epidemiology and preventability of hospital-onset bacteremia and fungemia in 2 hospitals in India

Author

Gandra, Sumanth, primary, Singh, Sanjeev K., additional, Chakravarthy, Murali, additional, Moni, Merlin, additional, Dhekane, Pruthu, additional, Mohamed, Zubair, additional, Shameen, Fathima, additional, Vasudevan, Anil K., additional, Senthil, Priyadarshini, additional, Saravanan, Tejaswini, additional, George, Anu, additional, Sinclair, Dorothy, additional, Stwalley, Dustin, additional, van Rheenen, Jacaranda, additional, Westercamp, Matthew, additional, Smith, Rachel M., additional, Leekha, Surbhi, additional, and Warren, David K., additional

Published
2023
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39. Epidemiology and preventability of hospital-onset bacteremia and fungemia in 2 hospitals in India

Author

Gandra, Sumanth, Singh, Sanjeev K., Chakravarthy, Murali, Moni, Merlin, Dhekane, Pruthu, Mohamed, Zubair, Shameen, Fathima, Vasudevan, Anil K., Senthil, Priyadarshini, Saravanan, Tejaswini, George, Anu, Sinclair, Dorothy, Stwalley, Dustin, van Rheenen, Jacaranda, Westercamp, Matthew, Smith, Rachel M., Leekha, Surbhi, and Warren, David K.

Abstract

AbstractObjective:Studies evaluating the incidence, source, and preventability of hospital-onset bacteremia and fungemia (HOB), defined as any positive blood culture obtained after 3 calendar days of hospital admission, are lacking in low- and middle-income countries (LMICs).Design, setting, and participants:All consecutive blood cultures performed for 6 months during 2020–2021 in 2 hospitals in India were reviewed to assess HOB and National Healthcare Safety Network (NHSN) reportable central-line–associated bloodstream infection (CLABSI) events. Medical records of a convenience sample of 300 consecutive HOB events were retrospectively reviewed to determine source and preventability. Univariate and multivariable logistic regression analyses were performed to identify factors associated with HOB preventability.Results:Among 6,733 blood cultures obtained from 3,558 hospitalized patients, there were 409 and 59 unique HOB and NHSN-reportable CLABSI events, respectively. CLABSIs accounted for 59 (14%) of 409 HOB events. There was a moderate but non-significant correlation (r = 0.51; P= .070) between HOB and CLABSI rates. Among 300 reviewed HOB cases, CLABSIs were identified as source in only 38 (13%). Although 157 (52%) of all 300 HOB cases were potentially preventable, CLABSIs accounted for only 22 (14%) of these 157 preventable HOB events. In multivariable analysis, neutropenia, and sepsis as an indication for blood culture were associated with decreased odds of HOB preventability, whereas hospital stay ≥7 days and presence of a urinary catheter were associated with increased likelihood of preventability.Conclusions:HOB may have utility as a healthcare-associated infection metric in LMIC settings because it captures preventable bloodstream infections beyond NHSN-reportable CLABSIs.

Published
2024
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40. Computational Prediction of Potential Vaccine Candidates From tRNA Encoded peptides (tREP) Using a Bioinformatic Workflow and Molecular Dynamics Validations

Author

Shanthappa, Pallavi M., Verma, Neeraj, George, Anu, Dhar, Pawan K., and Athri, Prashanth

Abstract

Transfer RNAs (tRNA) are non-coding RNAs. Encouraged by biological applications discovered for peptides derived from other non-coding genomic regions, we explore the possibility of deriving epitope-based vaccines from tRNA encoded peptides (tREP) in this study. Epitope-based vaccines have been identified as an effective strategy to mitigate safety and specificity concerns observed in vaccine development. In this study, we explore the potential of tREP as a source for epitope-based vaccines for virus pathogens. We present a computational workflow that uses verified data sources and community-validated predictive tools to produce a ranked list of plausible epitope-based vaccines starting from tRNA sequences. The top epitope, bound to the predicted HLA molecule, for the virus pathogen is computationally validated through 200 ns molecular dynamics (MD) simulations followed by binding free energy calculations. The simulation results indicate that two tRNA encoded epitope-based vaccines, RRHIDIVV and IMVRFSAE for Mamastrovirus 3 and Norovirus GII, respectively, are likely candidates. Peptides originating from tRNAs provide unexplored opportunities for vaccine design. Encouraged by our previous experimental study, which established the inhibitory properties of tREPs against infectious parasites, we have proposed a computationally validated set of peptides derived from tREPs as vaccines for viral pathogens.

Published
2024
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43. Serratia endocarditis, uncommon organism, with significant complications.

Author

George, Anu Anna, Singh, Tejveer, Bhattad, Pradnya Brijmohan, Sherif, Akil A., and Mishra, Ajay Kumar

Subjects
INTRAVENOUS drug abuse, SERRATIA, SERRATIA marcescens, GRAM-negative bacteria, ENDOCARDITIS, INFECTIVE endocarditis
Abstract

Serratia marcescens is an aerobic, Gram-negative bacillus predominantly seen in patients with intravenous drug use, immunosuppression, previous antibiotic exposure, and indwelling catheterization. Gram-negative organism causing infective endocarditis (IE) is rare. Serratia marcescens IE is uncommon and is reported to be seen in 0.14% of all cases. In this report, we discuss in detail about a 38-year-old man with a history of intravenous drug abuse presenting with S. marcescens related prosthetic valve IE. [ABSTRACT FROM AUTHOR]

Published
2023
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46. 2037. Epidemiology and Preventability of Hospital Onset Bacteremia and Fungemia in two Hospitals in India

Author

Gandra, Sumanth, primary, Singh, Sanjeev, additional, Chakravarthy, Murali, additional, Moni, Merlin, additional, Dhekane, Pruthu, additional, Mohamed, Zubair, additional, Kumar, Anil, additional, Kaushik, Arun, additional, Shameen, Fathima, additional, Senthil, Priyadarshini, additional, Saravanan, Tejaswini, additional, George, Anu, additional, Sinclair, Dorothy, additional, Stwalley, Dustin, additional, van Rheenen, Jacaranda, additional, Westercamp, Matthew, additional, Smith, Rachel Mann, additional, Leekha, Surbhi, additional, and Warren, David K, additional

Published
2022
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47. A review of the presentation and outcome of left ventricular thrombus in coronavirus disease 2019 infection

Author

Philip, Anil Mathew, George, Lina James, John, Kevin John, George, Anu Anna, Nayar, Jemimah, Sahu, Kamal Kant, Selvaraj, Vijairam, Lal, Amos, and Mishra, Ajay Kumar

Subjects
coronavirus disease 2019, left ventricular thrombus, coronavirus, coronavirus 2, Review Article, severe acute respiratory syndrome, thromboembolism, echocardiogram, thrombosis, acute coronary syndrome
Abstract

Background: Cardiovascular complications of the coronavirus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2), have been documented both in the acute phase and in convalescence. One such complication is the formation of the left ventricular (LV) thrombus. There is a lack of clarity regarding the incidence, risk factors, and management of this complication. Aim: The aim of the study is to identify the clinical presentation, risk factors and outcome of COVID-19 patients with left ventricular thrombus (LVT). Methods: A literature search was conducted to identify all case reports of COVID-19 with LVT in PubMed/Medline, Embase, Web of Science, and Google Scholar. Results: Among the 65 patients identified, 60 had LVT, either at admission, or during the acute phase of the illness. Six patients with mild symptoms during the acute phase of viral illness had only the COVID-19 antibody test positivity at the time LV thrombus was detected. Few of the patients (23.1%) had no comorbidities. The mean age of the patients was 52.8 years, and the youngest patient was 4 years old. This suggests that LVT formation can occur in young COVID-19 patients with no co-morbid conditions. Most of the patients (69.2%) had more than one site of thrombosis. A mortality rate of 23.1% was observed in our review, and ST-elevation myocardial infarction (STEMI) was diagnosed in 33.3% of those who died. Conclusions: A high degree of suspicion for LVT must be maintained in patients with known cardiac disease and those with new-onset arterial or venous thromboembolism, and such patients may benefit from a screening echocardiography at admission. Relevance for Patients: The patients with preexisting cardiovascular disease must take added precautions to prevent acquiring COVID-19 infection as there is a higher risk of developing LV thrombus. In patients who develop LVT in COVID-19, mortality rate is higher.

Published
2021

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