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2. What is the difference in outcomes between the ESD of large colonic and rectal lesions? French multicenter prospective cohort of 3901 procedures (FECCO- NCT04592003)

Author

Jacques, J., additional, Schaefer, M., additional, Wallenhorst, T., additional, Lepilliez, V., additional, Degand, T., additional, Le Baleur, Y., additional, Leclercq, P., additional, Berger, A., additional, Chabrun, E., additional, Brieau, B., additional, Barret, M., additional, Rahmi, G., additional, Legros, R., additional, Rivory, J., additional, Leblanc, S., additional, Geoffroy, V., additional, Zeevaert, J. B., additional, Albouys, J., additional, Perrod, G., additional, Yzet, C., additional, Hugo, L., additional, Chaussade, S., additional, Belle, A., additional, Florian, R., additional, Martin, D., additional, Lupu, A., additional, Chevaux, J. B., additional, and Pioche, M., additional

Published
2024
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3. Prospective Study Evaluating the Feasibility of Fiducial Markers Placement for Treatment of Esophageal or Rectal Cancers (FIDECHO)

Author

Camus, M., additional, Karsenti, D., additional, Levy, J., additional, Moreno-Garcia, M., additional, Coron, E., additional, Esch, A., additional, Williet, N., additional, Wangermez, M., additional, Stéphane, K., additional, Valats, J. C., additional, Pioche, M., additional, Geoffroy, V., additional, Huguet, F., additional, Audureau, E., additional, and Chaput, U., additional

Published
2024
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4. Endoscopic Submucosal Dissection in Inflammatory Bowel Disease Patients for Visible Dysplasia: a French Retrospective Multicentric Study

Author

Anneraud, A., additional, Geyl, S., additional, Stanislas, C., additional, Schaefer, M., additional, Berger, A., additional, Serrero, M., additional, Mathieu, P., additional, Leblanc, S., additional, Wallenhorst, T., additional, Chabrun, E., additional, Chevaux, J. B., additional, Legros, R., additional, Peyrin-Biroulet, L., additional, Seksik, P., additional, Stéphane, K., additional, Dray, X., additional, Barthet, M., additional, Lepilliez, V., additional, Laharie, D., additional, Benezech, A., additional, Yzet, C., additional, Perrod, G., additional, Rahmi, G., additional, Degand, T., additional, Brieau, B., additional, Geoffroy, V., additional, Le Baleur, Y., additional, Vuitton, L., additional, and Jacques, J., additional

Published
2023
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5. Improved screening for duodenoscope contamination after the regulations of 2018 a retrospective multicenter study

Author

Bour, Y., additional, Bertrand, X., additional, Geoffroy, V., additional, Belotti, L. Ehrhard, additional, Lavigne, T., additional, Boivineau, G., additional, Boytchev, I., additional, Jais, B., additional, Guilloux, A., additional, Chaput, U., additional, Rivory, J., additional, Caillol, F., additional, Rouquette, O., additional, Degand, T., additional, Muggeo, E., additional, Ah-Soune, P., additional, Simac, C., additional, Fassler, I., additional, Sakr, C., additional, Plastaras, L., additional, Privat, J., additional, Jezequel, J., additional, Cemachovic, I., additional, Simon, M., additional, Chevaux, J. B., additional, Vuitton, L., additional, and Koch, S., additional

Published
2023
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7. Impact of annual case volume on colorectal endoscopic submucosal dissection procedural outcomes and safety in a large multicentric prospective cohort study.

Author

Alfarone, L., Schaefer, M., Wallenhorst, T., Lepilliez, V., Degand, T., Le Baleur, Y., Leclercq, P., Berger, A., Chabrun, E., Brieau, B., Barret, M., Rahmi, G., Legros, R., Rivory, J., Leblanc, S., Geoffroy, V., Zeevaert, J. B., Albouys, J., Perrod, G., and Yzet, C.

Subjects
LONGITUDINAL method, COHORT analysis, DISSECTION
Abstract

This article discusses the impact of annual case volume on the outcomes and safety of colorectal endoscopic submucosal dissection (ESD) procedures. The study included 3770 colorectal ESDs performed in 13 participating centers. The results showed that high-volume centers had higher rates of en bloc resection, R0 resection, and curative resection compared to middle-volume and low-volume centers. The duration of the procedure was also shorter in high-volume centers. However, the study found that the volume of the center was not a significant risk factor for complications such as perforation. Overall, the study suggests that colorectal ESD can be successfully implemented in non-expert settings, but challenging cases should still be referred to experts. [Extracted from the article]

Published
2024
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11. Defect in the X-lipoyl-containing component of the pyruvate dehydrogenase complex in a patient with a neonatal lactic acidemia

Author

Geoffroy, V., Fouque, F., Benelli, C., Poggi, F., Saudubray, J.M., Lissens, W., Meirleir, L.D., Marsac, C., Lindsay, J.G., and Sanderson, S.J.

Subjects
Birth defects -- Genetic aspects, Lactic acidosis -- Genetic aspects
Abstract

The defect in a newborn with abnormal pyruvate dehydrogenase activity was localized to the X component. Pyruvate dehydrogenase (PDH) is an enzyme complex that is part of the metabolic pathway that extracts energy from carbohydrates. It is composed of three enzymes and a large protein called component X. Component X is believed to form a structure that holds the enzymes in proper orientation. The most common defect is found in enzyme 1. Shortly after birth, the baby developed severe metabolic problems. PDH deficiency was suspected and the baby was placed on a special diet. Enzymatic and genetic analyses of cultured cells found that enzymatic activity was 15% of normal and that the missing component in the complex was the X component. Genetic analysis showed that the gene for enzyme 1 was normal. The mother and father made normal amounts of component X, which suggests a new genetic mutation in the child., Studies of human pyruvate dehydrogenase (PDH) deficiency have shown that defects in the [E.sub.1] component are not common, with only a small number of defects associated specifically with the [E.sub.3], [...]

Published
1996

13. Les souris Aip+/–présentent une hypersécrétion modérée de GH et des anomalies de la production hypothalamique et de la réponse hypophysaire à la GHRH sans phénotype d’acromégalie évident

Author

Lecoq, A.L., primary, Zizzari, P., additional, Hage, M., additional, Clemessy, M., additional, Viengchareun, S., additional, Veldhuis, J.D., additional, Grybek, V., additional, Geoffroy, V., additional, Lombès, M., additional, Tolle, V., additional, Karhu, A., additional, Kappeler, L., additional, Chanson, P., additional, and Kamenicky, P., additional

Published
2015
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14. Calcium aluminate cements 2008 - The Centenary Conference

Author

Geoffroy, V., Bachelet, M., CROVISIER, J. L., Aouad, G., Damidot, D., UMR 7156, Université Louis-Pasteur/CNRS, Pharmacologie Cellulaire, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de géochimie de la surface (CGS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), École des Mines de Douai (Mines Douai EMD), and Institut Mines-Télécom [Paris] (IMT)

Subjects
[INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience; abstract simple

Published
2008

15. Influence de pseudomonas aeruginosa sur la vitesse d'altération de silicates

Author

Aouad, G., CROVISIER, J. L., Meyer, J. M., Stille, P., Damidot, D., Geoffroy, V., Centre for Materials and Processes (CERI MP), Ecole nationale supérieure Mines-Télécom Lille Douai (IMT Lille Douai), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), University of Strasbourg, Génétique moléculaire, génomique, microbiologie (GMGM), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Centre de géochimie de la surface (CGS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), École des Mines de Douai (Mines Douai EMD), Institut Mines-Télécom [Paris] (IMT), and UMR 7156, Université Louis-Pasteur/CNRS

Subjects
[PHYS]Physics [physics], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2007

16. Influence de Pseudomonas aeruginosa sur la dégradation de silicates : incidence sur la stabilité de matrices de confinement de déchets et d'un mâchefer industriel

Author

Aouad, G., CROVISIER, J. L., Geoffroy, V., Meyer, J. M., Stille, P., Damidot, D., Centre de géochimie de la surface (CGS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), UMR 7156, Université Louis-Pasteur/CNRS, École des Mines de Douai (Mines Douai EMD), and Institut Mines-Télécom [Paris] (IMT)

Subjects
[SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; abstract simple

Published
2006

17. Influence de Pseudomonas aeruginosa sur la dégradation de silicates : incidence sur la stabilité de matrices de confinement de 12hets et d'un mâchefer industriel

Author

Aouad, G., CROVISIER, J. L., Geoffroy, V., Meyer, J. M., Stille, P., DAMIDO, D., École des Mines de Douai (Mines Douai EMD), Institut Mines-Télécom [Paris] (IMT), Centre de géochimie de la surface (CGS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), UMR 7156, Université Louis-Pasteur/CNRS, Génétique moléculaire, génomique, microbiologie (GMGM), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
[INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience; abstract simple

Published
2006

18. Permanent N-cadherin overexpression in pre-osteoblasts decreases osteoblast differentiation in vitro and bone mass in vivo by antagonizing Wnt signaling

Author

Eric Hay, Laplantine, E., Frain, M., Geoffroy, V., Mueller, R., Marie, P. J., FRAIN, Monique, Os et articulations, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Génétique moléculaire du développement, Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-IFR36-Institut National de la Santé et de la Recherche Médicale (INSERM), and Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2006

19. Definition of a growth medium to study interactions between Pseudomonas aeruginosa and silicates

Author

Aouad, G., Geoffroy, V., CROVISIER, J. L., Damidot, D., Stille, P., Centre for Materials and Processes (CERI MP), Ecole nationale supérieure Mines-Télécom Lille Douai (IMT Lille Douai), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), UMR 7156, Université Louis-Pasteur/CNRS, University of Strasbourg, École des Mines de Douai (Mines Douai EMD), Institut Mines-Télécom [Paris] (IMT), Centre de géochimie de la surface (CGS), and Institut national des sciences de l'Univers (INSU - CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDE]Environmental Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2005

23. Potential adaptation of Miscanthus x giganteus for the phytoremediation of a former mine site highly contaminated

Author

Pichon, Martin, Hitmi, Adnan (Dr.), Geoffroy, V. (Dr.), Joussein, Emmanuel (Dr.), Schloter, Michael (Prof. Dr.), Schwartz, C. (Prof.), Caner, Laurent (Dr.), Munch, Jean Charles (Prof. Dr. Dr.), Wanat, Nastasia, Pichon, Martin, Hitmi, Adnan (Dr.), Geoffroy, V. (Dr.), Joussein, Emmanuel (Dr.), Schloter, Michael (Prof. Dr.), Schwartz, C. (Prof.), Caner, Laurent (Dr.), Munch, Jean Charles (Prof. Dr. Dr.), and Wanat, Nastasia

Abstract

Contaminated soils such as former mine sites are unsuitable for the food production. Metals and metalloids concentration are usually very high. The main aim of this thesis was the evaluation of the adaptation capacity of a bioenergetic plant, Miscanthus x giganteus, on soils developed from mining wastes contaminated in arsenic (10% in mass concentration) and lead (5%, mass concentration). Despite the contamination, results show that: (i) Miscanthus is able to adapt without any physiological stress, (ii) biomass yield is reduced, (iii) soil to plant transfer of As and Pb is low owing to a specific mineralogy limiting the elements solubilization, (iv) microorganisms involved in nitrate formation are present and (v) M. x giganteus is an excellent plant to phytostabilise the site., Frühere Bergbaustandorte weisen oft belastete Böden auf und sind für die Landwirtschaft nicht nutzbar, da sie eine hohe Konzentration vom Metallen und Halbmetallen (beispielsweise Arsen und Blei) haben. Das Hauptziel dieser Doktorarbeit bestand darin, die Anpassungsfähigkeit der Energiepflanze Miscanthus x giganteus abzuschätzen. Die Ergebnisse der Arbeit zeigen (i) Miscanthus besitzt eine hohe Anpassungsfähigkeit, (ii) Die Biomasse der Pflanze ist auf belasteten Böden reduziert (iii) der Transfer von Arsen und Blei vom Boden in die Pflanze war gering (iv) Mikroorganismen zur Nitrifizierung waren im Boden aktiv und (v) Miscanthus ist eine geeignete Pflanze zur Phytostabilisierung von Böden.

Published
2013

24. Potential adaptation of Miscanthus x giganteus for the phytoremediation of a former mine site highly contaminated

Author

Munch, Jean Charles (Prof. Dr. Dr.), Munch, Jean Charles (Prof. Dr. Dr.);Schwartz, C. (Prof.);Schloter, Michael (Prof. Dr.);Geoffroy, V. (Dr.);Hitmi, Adnan (Dr.);Joussein, Emmanuel (Dr.);Caner, Laurent (Dr.);Pichon, Martin, Wanat, Nastasia, Munch, Jean Charles (Prof. Dr. Dr.), Munch, Jean Charles (Prof. Dr. Dr.);Schwartz, C. (Prof.);Schloter, Michael (Prof. Dr.);Geoffroy, V. (Dr.);Hitmi, Adnan (Dr.);Joussein, Emmanuel (Dr.);Caner, Laurent (Dr.);Pichon, Martin, and Wanat, Nastasia

Abstract

Contaminated soils such as former mine sites are unsuitable for the food production. Metals and metalloids concentration are usually very high. The main aim of this thesis was the evaluation of the adaptation capacity of a bioenergetic plant, Miscanthus x giganteus, on soils developed from mining wastes contaminated in arsenic (10% in mass concentration) and lead (5%, mass concentration). Despite the contamination, results show that: (i) Miscanthus is able to adapt without any physiological stress, (ii) biomass yield is reduced, (iii) soil to plant transfer of As and Pb is low owing to a specific mineralogy limiting the elements solubilization, (iv) microorganisms involved in nitrate formation are present and (v) M. x giganteus is an excellent plant to phytostabilise the site., Frühere Bergbaustandorte weisen oft belastete Böden auf und sind für die Landwirtschaft nicht nutzbar, da sie eine hohe Konzentration vom Metallen und Halbmetallen (beispielsweise Arsen und Blei) haben. Das Hauptziel dieser Doktorarbeit bestand darin, die Anpassungsfähigkeit der Energiepflanze Miscanthus x giganteus abzuschätzen. Die Ergebnisse der Arbeit zeigen (i) Miscanthus besitzt eine hohe Anpassungsfähigkeit, (ii) Die Biomasse der Pflanze ist auf belasteten Böden reduziert (iii) der Transfer von Arsen und Blei vom Boden in die Pflanze war gering (iv) Mikroorganismen zur Nitrifizierung waren im Boden aktiv und (v) Miscanthus ist eine geeignete Pflanze zur Phytostabilisierung von Böden.

Published
2013

25. Targeted high-throughput sequencing for diagnosis of genetically heterogeneous diseases: efficient mutation detection in Bardet-Biedl and Alstrom Syndromes.

Author

Redin, C, Le Gras, S., Mhamdi, O, Geoffroy, V, Stoetzel, C, Vincent, Mc, Chiurazzi, Pietro, Lacombe, D, Ouertani, I, Petit, F, Till, M, Verloes, A, Jost, B, Chaabouni, Hb, Dollfus, H, Mandel, Jl, Muller, J., Chiurazzi, Pietro (ORCID:0000-0001-5104-1521), Redin, C, Le Gras, S., Mhamdi, O, Geoffroy, V, Stoetzel, C, Vincent, Mc, Chiurazzi, Pietro, Lacombe, D, Ouertani, I, Petit, F, Till, M, Verloes, A, Jost, B, Chaabouni, Hb, Dollfus, H, Mandel, Jl, Muller, J., and Chiurazzi, Pietro (ORCID:0000-0001-5104-1521)

Abstract

Background Bardet-Biedl syndrome (BBS) is a pleiotropic recessive disorder that belongs to the rapidly growing family of ciliopathies. It shares phenotypic traits with other ciliopathies, such as Alstro ̈ m syndrome (ALMS), nephronophthisis (NPHP) or Joubert syndrome. BBS mutations have been detected in 16 different genes (BBS1-BBS16) without clear genotypeto-phenotype correlation. This extensive genetic heterogeneity is a major concern for molecular diagnosis and genetic counselling. While various strategies have been recently proposed to optimise mutation detection, they either fail to detect mutations in a majority of patients or are time consuming and costly. Method We tested a targeted exon-capture strategy coupled with multiplexing and high-throughput sequencing on 52 patients: 14 with known mutations as proof-of-principle and 38 with no previously detected mutation. Thirty genes were targeted in total including the 16 BBS genes, the 12 known NPHP genes, the single ALMS gene ALMS1 and the proposed modifier CCDC28B. Results This strategy allowed the reliable detection of causative mutations (including homozygous/ heterozygous exon deletions) in 68% of BBS patients without previous molecular diagnosis and in all proof-ofprinciple samples. Three probands carried homozygous truncating mutations in ALMS1 confirming the major phenotypic overlap between both disorders. The efficiency of detecting mutations in patients was positively correlated with their compliance with the classical BBS phenotype (mutations were identified in 81% of ‘classical’ BBS patients) suggesting that only a few true BBS genes remain to be identified. We illustrate some interpretation problems encountered due to the multiplicity of identified variants. Conclusion This strategy is highly efficient and cost effective for diseases with high genetic heterogeneity, and guarantees a quality of coverage in coding sequences of target genes suited for diagnosis purposes.

Published
2012

41. Effect of pyoverdine supply on cadmium and nickel complexation and phytoavailability in hydroponics.

Author

Ferret, C., Cornu, J., Elhabiri, M., Sterckeman, T., Braud, A., Jezequel, K., Lollier, M., Lebeau, T., Schalk, I., and Geoffroy, V.

Subjects
CADMIUM, NICKEL, PYOVERDINES, POLLUTION, ENVIRONMENTAL sciences
Abstract

Siderophores are chelators with a high selectivity for Fe(III) and a good affinity for divalent metals, including Cd(II) and Ni(II). Inoculation with siderophore-producing bacteria (SPB) has thus been proposed as an alternative to chelator supply in phytoremediation. Accurate assessments of the potential of this association require a dissection of the interaction of siderophores with metals at the soil-root interface. This study focuses on pyoverdine (Pvd), the main siderophore produced by Pseudomonas aeruginosa. We first assessed the ability of Pvd to coordinate Ni(II). The stability constant of Pvd-Ni(II) (log K = 10.9) was found to be higher than that of Pvd-Cd(II) (log K = 8.2). We then investigated the effect of a direct supply of Pvd on the mobilization, speciation, and phytoavailability of Cd and Ni in hydroponics. When supplied at a concentration of 50 μM, Pvd selectively promoted Ni mobilization from smectite. It decreased plant Ni and Cd contents and the free ionic fractions of these two metals, consistent with the free ion activity model. Pvd had a more pronounced effect for Ni than for Cd, as predicted from its coordination properties. Inoculation with P. aeruginosa had a similar effect on Ni phytoavailability to the direct supply of Pvd. [ABSTRACT FROM AUTHOR]

Published
2015
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46. Contribution a l'etude des elements transposables chez Apis mellifica

Author

de Geoffroy, V., Station de recherches de nématologie et de génétique moléculaire des invertébrés, Institut National de la Recherche Agronomique (INRA), and Institut Universitaire de Technologie (IUT), Villeurbanne, FRA.

Subjects
APIS MELLIFICA, [SDV]Life Sciences [q-bio]
Published
1990

47. Influence de Pseudomonas aeruginosasur la vitesse d'altération de silicates

Author

Aouad, G., Crovisier, J.-L., Meyer, J.-M., Stille, P., Damidot, D., Geoffroy, V., Aouad, G., Crovisier, J.-L., Meyer, J.-M., Stille, P., Damidot, D., and Geoffroy, V.

Abstract

Il est désormais bien établi que l'altération des roches, comme celle des matériaux d'origine anthropique, n'est pas le seul fait de l'interaction avec une phase aqueuse purement minérale. Les composés organiques et l'activité des micro-organismes interviennent également, tant dans la dégradation que dans les minéralisations secondaires. Toutefois, compte tenu de la complexité des milieux réactionnels, il n'existe pas de validation convaincante du rôle de certaines bactéries sur la vitesse de dégradation des silicates complexes. L'objectif de ce travail était d'évaluer expérimentalement (pendant 133 jours) l'effet d'une seule bactérie largement répandue dans la nature (Pseudomonas aeruginosa) sur la vitesse de dégradation de quelques silicates d'intérêt environnemental. Les matériaux testés sont un mâchefer résultant de l'incinération d'ordures ménagères (MIOM), un vitrifiât de mâchefer industriel (JAP) et un verre basaltique (Basalte). Les expériences ont été réalisées en milieu stérile et en milieu biotique au cours desquelles le milieu de culture a été périodiquement renouvelé. Les résultats indiquent que les vitesses sont systématiquement plus grandes en milieu stérile qu'en milieu biotique, et cela dans des proportions allant de 40 à 60 % suivant l'élément et le matériau. Des différences sont toutefois constatées selon le matériau considéré. Le MIOM s'altère à une vitesse moyenne de 5,3×10-4g. m-2. j-1en milieu biotique et 7,6×10-4g. m-2. j-1en milieu stérile. La vitesse d'altération du verre JAP en présence de P. aeruginosaest de 7,7×10-4g. m-2. j-1et de 12,8×10-4g. m-2. j-1en l'absence de bactéries. Le Basalte s'altère avec une vitesse égale à 18,3×10-4g. m-2. j-1en biotique et 29,8×10-4g. m-2. j-1en stérile. Contrairement à ce qui a été décrit jusqu'à présent dans la littérature, cette étude montre que les bactéries jouent un rôle protecteur vis-à-vis des matériaux testés.

Published
2006
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