1. Where youth matters—clinicopathologic characteristics and emerging trends in treatment and outcomes in young Irish women with breast cancer
- Author
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Jennifer Kielty, Janice M. Walshe, Cecily Quinn, John Crown, Enda W. McDermott, Niamh Coleman, Megan Greally, Lynda M McSorley, Giuseppe Gullo, Christina Malouf, Catherine M. Kelly, Geoffrey Das, Geoffrey Watson, and Ruth Prichard
- Subjects
Adult ,medicine.medical_specialty ,Receptor, ErbB-2 ,medicine.medical_treatment ,Breast Neoplasms ,Triple Negative Breast Neoplasms ,Disease ,030204 cardiovascular system & hematology ,Cohort Studies ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,030212 general & internal medicine ,Lymph node ,Pathological ,Mastectomy ,Neoadjuvant therapy ,Neoplasm Staging ,Chemotherapy ,business.industry ,Mortality rate ,General Medicine ,medicine.disease ,Combined Modality Therapy ,Neoadjuvant Therapy ,Treatment Outcome ,medicine.anatomical_structure ,Receptors, Estrogen ,Axilla ,Lymph Node Excision ,Women's Health ,Female ,Lymph Nodes ,Neoplasm Recurrence, Local ,business ,Ireland - Abstract
Young women with breast cancer (YWBC) represent 7–12% of breast cancer diagnoses and ostensibly have more biologically aggressive subtypes with higher relapse and mortality rates. We studied the clinical and pathological characteristics in YWBC and examined how outcomes and treatment have evolved. YWBC were identified from pathology databases at two tertiary centers. Patients were divided into two cohorts: those diagnosed from 2000 to 2005 (C1) and from 2006 to 2015 (C2). Data were retrieved from clinical, radiology, and histology databases. Statistical analysis was performed using R® (V3.2.0). We identified 345 patients. Median age was 36 years (23–39 years). Mastectomy was performed in 232 patients (67.2%) and axillary lymph node clearance (ALNC) in 207 patients (60% [C1 82.7 vs. C2: 49.4%, p
- Published
- 2018
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