19 results on '"Genty, Jean Baptiste"'
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2. Indirect effect of impulsivity on suicide risk through self-esteem and depressive symptoms in a population with treatment-resistant depression: A FACE-DR study
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Salles, Juliette, Stephan, Florian, Molière, Fanny, Bennabi, Djamila, Haffen, Emmanuel, Bouvard, Alexandra, Walter, Michel, Allauze, Etienne, Llorca, Pierre Michel, Genty, Jean Baptiste, Leboyer, Marion, Holtzmann, Jérôme, Nguon, Anne Sophie, D'Amato, Thierry, Rey, Romain, Horn, Mathilde, Vaiva, Guillaume, Fond, Guillaume, Richieri, Raphaelle, Hennion, Vincent, Etain, Bruno, El-Hage, Wissam, Camus, Vincent, Courtet, Philippe, Aouizerate, Bruno, and Yrondi, Antoine
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- 2024
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3. Long-term benzodiazepine prescription in treatment-resistant depression: A national FACE-TRD prospective study
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Fond, Guillaume, Faugere, Mélanie, Boyer, Laurent, Peri, Pauline, Stephan, Florian, Moliere, Fanny, Anguill, Loic, Bennabi, Djamila, Haffen, Emmanuel, Bouvard, Alexandra, Walter, Michel, Samalin, Ludovic, Llorca, Pierre Michel, Genty, Jean Baptiste, Leboyer, Marion, Holtzmann, Jérôme, Nguon, Anne Sophie, Rey, Romain, Horn, Mathilde, Vaiva, Guillaume, Hennion, Vincent, Etain, Bruno, El-Hage, Wissam, Camus, Vincent, Courtet, Philippe, Aouizerate, Bruno, Yrondi, Antoine, Lancon, Christophe, and Richieri, Raphaelle
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- 2023
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4. Diurnal symptoms of sleepiness and dysfunction predict future suicidal ideation in a French cohort of outpatients (FACE-DR) with treatment resistant depression: A 1-year prospective study about sleep markers
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Maruani, Julia, Molière, Fanny, Godin, Ophelia, Yrondi, Antoine, Bennabi, Djamila, Richieri, Raphaelle, El-Hage, Wissan, Allauze, Etienne, Anguill, Loic, Bouvard, Alexandra, Camus, Vincent, Dorey, Jean-Michel, Etain, Bruno, Fond, Guillaume, Genty, Jean-Baptiste, Haffen, Emmanuel, Holtzmann, Jérôme, Horn, Mathilde, Kazour, François, Nguon, Anne-Sophie, Petrucci, Jean, Rey, Romain, Stephan, Florian, Vaiva, Guillaume, Walter, Michel, Lejoyeux, Michel, Leboyer, Marion, Llorca, Pierre-Michel, Courtet, Philippe, Aouizerate, Bruno, and Geoffroy, Pierre A.
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- 2023
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5. Recommendations of the treatment-resistant depression expert center network for promoting tobacco smoking cessation based on the results from the real-world FACE-TRD national cohort
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Korchia, Théo, Faugere, Mélanie, Suc, Nicolas, Garosi, Alexandra, Andrieu-Haller, Christelle, Breyton, Martin, Godin, Ophélia, Aouizerate, Bruno, Arbus, Christophe, Bennabi, Djamila, Bellivier, Frank, Bougerol, Thierry, Camus, Vincent, Courtet, Philippe, Doumy, Olivier, El-Hage, Wissam, Genty, Jean-Baptiste, Haffen, Emmanuel, Holtzmann, Jérome, Horn, Mathilde, Leboyer, Marion, Llorca, Pierre-Michel, Maruani, Julia, Moirand, Rémi, Moliere, Fanny, Petrucci, Jean, Rey, Romain, Samalin, Ludovic, Stephan, Florian, Vaiva, Guillaume, Walter, Michel, Yrondi, Antoine, Boyer, Laurent, Lancon, Christophe, Richieri, Raphaelle, and Fond, Guillaume
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- 2022
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6. Childhood Trauma increases suicidal behaviour in a treatment-resistant depression population: a FACE-DR report
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Aouizerate, B., Bennabi, D., Leboyer, M., Haffen, E., Llorca, P.M., Barteau, V., Bensalem, S., Laouamri, H., Souryis, Karmene, Mallet, L., Yon, L., Petrucci, J., Genty, J.B., Yrondi, A., Pierre, D., Schmitt, L., Sarrail, M., Bennabi, Djamila, Ryff, I., Beuchet, E., Tio, G., Cappe, C., Clerc, E., Garnier, M., Honciuc, R.M., Allauze, E., Blanc, O., Bellivier, F., Allaili, N., Nieto, I., Meheust, J., Sunthavy, Y., Maruani, J., Bougerol, T., Polosan, M., Courvoisier, P., Holtzmann, J., Fredembach, B., Foubert-Andreani, S., Camus, V., El Hage, W., D’Amato, T., Haesebaert, F., Dubien, C., Lefebvre, M., Meznad, A., Brunelin, J., Moirand, R., Doumy, O., Lancon, C., Richieri, R., Peri, P., Faugere, M., Faget-Agius, C., Courtet, P., Boulenger, J.P., Moliere, F., Stephan, F., Walter, M., Mesmeur, C., Vaiva, G., Horn, M., Yrondi, Antoine, Vaiva, Guillaume, Walter, Michel, D Amato, Thierry, Bellivier, Frank, Bougerol, Thierry, Camus, Vincent, Doumy, Olivier, Genty, Jean-Baptiste, Haffen, Emmanuel, Holtzmann, Jérôme, Horn, Mathilde, Lançon, Christophe, Leboyer, Marion, Llorca, Pierre-Michel, Maruani, Julia, Moirand, Rémi, Molière, Fanny, Petrucci, Jean, Richieri, Raphaelle, Samalin, Ludovic, Schmitt, Laurent, Stephan, Florian, Courtet, Philippe, El-Hage, Wissam, and Aouizerate, Bruno
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- 2021
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7. Evolution of Cognitive Impairments in Treatment-Resistant Depression: Results from the Longitudinal French Centers of Expertise for Treatment-Resistant Depression (FACE-DR) Cohort
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Vancappel, Alexis, primary, Dansou, Yecodji, additional, Godin, Ophelia, additional, Haffen, Emmanuel, additional, Yrondi, Antoine, additional, Stephan, Florian, additional, Richieri, Raphaelle Marie, additional, Molière, Fanny, additional, Holtzmann, Jérôme, additional, Horn, Mathilde, additional, Allauze, Etienne, additional, Genty, Jean Baptiste, additional, Bouvard, Alex, additional, Dorey, Jean-Michel, additional, Hennion, Vincent, additional, Camus, Vincent, additional, Fond, Guillaume, additional, Peran, Barbara, additional, Walter, Michel, additional, Anguill, Loic, additional, Scotto D’apolina, Charlotte, additional, Vilà, Estelle, additional, Fredembach, Benjamin, additional, Petrucci, Jean, additional, Rey, Romain, additional, Nguon, Anne Sophie, additional, Etain, Bruno, additional, Carminati, Mathilde, additional, Courtet, Philippe, additional, Vaiva, Guillaume, additional, Llorca, Pierre Michel, additional, Leboyer, Marion, additional, Aouizerate, Bruno, additional, Bennabi, Djamila, additional, and El Hage, Wissam, additional
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- 2023
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8. Shared Decision-Making: a Systematic Review Focusing on Mood Disorders
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Samalin, Ludovic, Genty, Jean-Baptiste, Boyer, Laurent, Lopez-Castroman, Jorge, Abbar, Mocrane, and Llorca, Pierre-Michel
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- 2018
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9. Occurrence of Side Effects in Treatment-Resistant Depression: Role of Clinical, Socio-Demographic and Environmental Characteristics
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Levy, Anna, primary, El-Hage, Wissam, additional, Bennabi, Djamila, additional, Allauze, Etienne, additional, Bouvard, Alexandra, additional, Camus, Vincent, additional, Courtet, Philippe, additional, Dorey, Jean-Michel, additional, Etain, Bruno, additional, Fond, Guillaume, additional, Genty, Jean-Baptiste, additional, Holtzmann, Jérôme, additional, Horn, Mathilde, additional, Leboyer, Marion, additional, Llorca, Pierre-Michel, additional, Meyrel, Manon, additional, Molière, Fanny, additional, Nguon, Anne-Sophie, additional, Petrucci, Jean, additional, Rey, Romain, additional, Richieri, Raphaelle, additional, Stephan, Florian, additional, Vaiva, Guillaume, additional, Walter, Michel, additional, Haffen, Emmanuel, additional, Aouizerate, Bruno, additional, and Yrondi, Antoine, additional
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- 2021
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10. Acute Effects Of Static And Dynamic Stretching On Stiffness Index Of Plantar Flexor Muscles: 1931 Board #276 May 28, 2: 00 PM - 3: 30 PM
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Babault, Nicolas, Genty, Jean-Baptiste, Bouvier, Tom, Opplert, Jules, and Deley, Gaëlle
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- 2015
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11. Childhood Trauma increases suicidal behaviour in a treatment-resistant depression population: a FACE-DR report
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Yrondi, Antoine, primary, Vaiva, Guillaume, additional, Walter, Michel, additional, D Amato, Thierry, additional, Bellivier, Frank, additional, Bennabi, Djamila, additional, Bougerol, Thierry, additional, Camus, Vincent, additional, Doumy, Olivier, additional, Genty, Jean-Baptiste, additional, Haffen, Emmanuel, additional, Holtzmann, Jérôme, additional, Horn, Mathilde, additional, Lançon, Christophe, additional, Leboyer, Marion, additional, Llorca, Pierre-Michel, additional, Maruani, Julia, additional, Moirand, Rémi, additional, Molière, Fanny, additional, Petrucci, Jean, additional, Richieri, Raphaelle, additional, Samalin, Ludovic, additional, Schmitt, Laurent, additional, Stephan, Florian, additional, Courtet, Philippe, additional, El-Hage, Wissam, additional, Aouizerate, Bruno, additional, Aouizerate, B., additional, Bennabi, D., additional, Leboyer, M., additional, Haffen, E., additional, Llorca, P.M., additional, Barteau, V., additional, Bensalem, S., additional, Laouamri, H., additional, Souryis, Karmene, additional, Mallet, L., additional, Yon, L., additional, Petrucci, J., additional, Genty, J.B., additional, Yrondi, A., additional, Pierre, D., additional, Schmitt, L., additional, Sarrail, M., additional, Ryff, I., additional, Beuchet, E., additional, Tio, G., additional, Cappe, C., additional, Clerc, E., additional, Garnier, M., additional, Honciuc, R.M., additional, Allauze, E., additional, Blanc, O., additional, Bellivier, F., additional, Allaili, N., additional, Nieto, I., additional, Meheust, J., additional, Sunthavy, Y., additional, Maruani, J., additional, Bougerol, T., additional, Polosan, M., additional, Courvoisier, P., additional, Holtzmann, J., additional, Fredembach, B., additional, Foubert-Andreani, S., additional, Camus, V., additional, El Hage, W., additional, D’Amato, T., additional, Haesebaert, F., additional, Dubien, C., additional, Lefebvre, M., additional, Meznad, A., additional, Brunelin, J., additional, Moirand, R., additional, Doumy, O., additional, Lancon, C., additional, Richieri, R., additional, Peri, P., additional, Faugere, M., additional, Faget-Agius, C., additional, Courtet, P., additional, Boulenger, J.P., additional, Moliere, F., additional, Stephan, F., additional, Walter, M., additional, Mesmeur, C., additional, Vaiva, G., additional, and Horn, M., additional
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- 2021
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12. Treatment-Resistant Depression in a Real-World Setting: First Interim Analysis of Characteristics, Healthcare Resource Use, and Utility Values of the FondaMental Cohort
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Yrondi, Antoine, primary, Bennabi, Djamila, additional, Haffen, Emmanuel, additional, Quelard, Delphine, additional, Samalin, Ludovic, additional, Maruani, Julia, additional, Allauze, Etienne, additional, Pierre, Damien, additional, Bougerol, Thierry, additional, Camus, Vincent, additional, D’Amato, Thierry, additional, Doumy, Olivier, additional, Holtzmann, Jérôme, additional, Lançon, Christophe, additional, Moliere, Fanny, additional, Moirand, Rémi, additional, Nieto, Isabel, additional, Richieri, Raphaëlle, additional, Horn, Mathilde, additional, Schmitt, Laurent, additional, Stephan, Florian, additional, Genty, Jean-Baptiste, additional, Vaiva, Guillaume, additional, Walter, Michel, additional, Courtet, Philippe, additional, Leboyer, Marion, additional, Llorca, Pierre-Michel, additional, Marguet, Sophie, additional, Dennis, Nathalie, additional, Schaetz, Dominique, additional, El-Hage, Wissam, additional, and Aouizerate, Bruno, additional
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- 2020
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13. Association between anhedonia and suicidal events in patients with mood disorders: A 3‐year prospective study
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Ducasse, Déborah, primary, Dubois, Jonathan, additional, Jaussent, Isabelle, additional, Azorin, Jean‐Michel, additional, Etain, Bruno, additional, Gard, Sébastien, additional, Henry, Chantal, additional, Bougerol, Thierry, additional, Kahn, Jean‐Pierre, additional, Aubin, Valérie, additional, Bellivier, Frank, additional, Belzeaux, Raoul, additional, Dubertret, Caroline, additional, Dubreucq, Julien, additional, Llorca, Pierre‐Michel, additional, Loftus, Josephine, additional, Passerieux, Christine, additional, Polosan, Mircea, additional, Samalin, Ludovic, additional, Leboyer, Marion, additional, Yrondi, Antoine, additional, Bennabi, Djamila, additional, Haffen, Emmanuel, additional, Maruani, Julia, additional, Allauze, Etienne, additional, Camus, Vincent, additional, D'Amato, Thierry, additional, Doumy, Olivier, additional, Holtzmann, Jérôme, additional, Lançon, Christophe, additional, Moliere, Fanny, additional, Moirand, Rémi, additional, Richieri, Raphaëlle Marie, additional, Horn, Mathilde, additional, Schmitt, Laurent, additional, Stephan, Florian, additional, Genty, Jean‐Baptiste, additional, Vaiva, Guillaume, additional, Walter, Michel, additional, El‐Hage, Wissam, additional, Aouizerate, Bruno, additional, Olié, Emilie, additional, and Courtet, Philippe, additional
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- 2020
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14. Relationship between Childhood Physical Abuse and Clinical Severity of Treatment-Resistant Depression in a Geriatric Population
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Yrondi, Antoine, primary, Arbus, Christophe, additional, Bennabi, Djamila, additional, D'Amato, Thierry, additional, Bellivier, Frank, additional, Bougerol, Thierry, additional, Camus, Vincent, additional, Courtet, Philippe, additional, Doumy, Olivier, additional, Genty, Jean Baptiste, additional, Holtzmann, Jérôme, additional, Horn, Mathilde, additional, Lancon, Christophe, additional, Leboyer, Marion, additional, Llorca, Pierre-Michel, additional, Maruani, Julia, additional, Moirand, Rémi, additional, Molière, Fanny, additional, Petrucci, Jean, additional, Richieri, Raphaelle, additional, Samalin, Ludovic, additional, Stephan, Florian, additional, Vaiva, Guillaume, additional, Walter, Michel, additional, Haffen, Emmanuel, additional, Aouizerate, Bruno, additional, and El-Hage, Wissam, additional
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- 2020
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15. Prevalence of Metabolic Syndrome and Associated Factors in a Cohort of Individuals With Treatment-Resistant Depression
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Godin, Ophelia, Bennabi, Djamila, Yrondi, Antoine, Richieri, Raphaëlle, D’amato, Thierry, Bellivier, Franck, Bougerol, Thierry, Horn, Mathilde, Camus, Vincent, Courtet, Philippe, Doumy, Olivier, Genty, Jean Baptiste, El-Hage, Wissam, Haesebaert, Frédéric, Holtzmann, Jérôme, Lançon, Christophe, Leboyer, Marion, Llorca, Pierre Michel, Maruani, Julia, Moliere, Fanny, Samalin, Ludovic, Schmitt, Laurent, Stéphan, Florian, Vaiva, Guillaume, Walter, Michel, Aouizerate, Bruno, Haffen, Emmanuel, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Fondation FondaMental [Créteil], Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) (NEURO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Toulouse Neuro Imaging Center (ToNIC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Centre Hospitalier le Vinatier [Bron], Neurobiologie et Psychiatrie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire [Grenoble] (CHU), Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), CHU Toulouse [Toulouse], Hopital de Bohars - CHRU Brest (CHU - BREST ), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Hôpital Charles Perrens, Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (EA 481) (NEURO), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193 (SCALab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Centre hospitalier Charles Perrens [Bordeaux]
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[SCCO]Cognitive science ,Prevalence of metabolic syndrome (MetS) ,[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Treatment-resistant depression (TRD) - Abstract
International audience; BACKGROUND:The aim of this study was to estimate the prevalence of metabolic syndrome (MetS) and its components in a cohort of French patients with treatment-resistant depression (TRD) and to determine correlations with sociodemographic, clinical, and treatment-related factors.METHODS:From 2012 to 2018, 205 patients who met DSM-IV criteria for major depressive episode with moderate-to-severe symptoms (Montgomery-Asberg Depression Rating Scale score ≥ 20), and at least Stage II resistance according to Thase and Rush criteria were enrolled in the FondaMental Advanced Centers of Expertise in Resistant Depression (FACE-DR) cohort. Data on sociodemographic and clinical characteristics, lifestyle information, and treatment and comorbidities were collected, and a blood sample was drawn. MetS was defined according to the criteria of the International Diabetes Federation.RESULTS:Overall, 38% of individuals with TRD met criteria for MetS. The frequency of MetS was significantly higher in men than in women only for patients aged 40 years or older (46.3% vs 35.2%, P = .0427). Moreover, whereas the management for diabetes was good, less than one-third of the patients with high blood pressure or dyslipidemia were treated for these conditions. Multivariate analysis showed that individuals with abnormal plasma c-reactive protein levels had a 3-fold increased risk (95% CI, 1.5-5.2) of having MetS, independent of other potential confounders.CONCLUSION:The prevalence of MetS is higher in patients with TRD than in those with other psychiatric disorders and characterized by a considerable undertreatment of some components of MetS in this population. Diagnosis and treatment of the components of MetS should be systematically performed to prevent the occurrence of cardiovascular diseases in patients with TRD. These findings highlight the need for integrated care, with more interaction and coordination between psychiatrists and primary care providers.
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- 2019
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16. Relationship between childhood physical abuse and clinical severity of treatment-resistant depression in a geriatric population.
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Yrondi, Antoine, Arbus, Christophe, Bennabi, Djamila, D'Amato, Thierry, Bellivier, Frank, Bougerol, Thierry, Camus, Vincent, Courtet, Philippe, Doumy, Olivier, Genty, Jean-Baptiste, Holtzmann, Jérôme, Horn, Mathilde, Lancon, Christophe, Leboyer, Marion, Llorca, Pierre-Michel, Maruani, Julia, Moirand, Rémi, Molière, Fanny, Petrucci, Jean, and Richieri, Raphaelle
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PHYSICAL abuse ,MENTAL depression ,CHILD abuse ,SELF-esteem - Abstract
Introduction: We assessed the correlation between childhood maltreatment (CM) and severity of depression in an elderly unipolar Treatment-Resistant Depression (TRD) sample. Methods: Patients were enrolled from a longitudinal cohort (FACE-DR) of the French Network of Expert TRD Centres. Results: Our sample included 96 patients (33% of the overall cohort) aged 60 years or above, with a mean age of 67.2 (SD = 5.7). The majority of the patients were female (62.5%). The Montgomery and Asberg Depression Rating Scale (MADRS) and Quick Inventory Depression Scale-Self Report (QIDS-SR) mean scores were high, 28.2 (SD = 7.49) [MADRS score range: 0–60; moderate severity≥20, high severity≥35] and 16.5 (SD = 4.94) [IDS-SR score range: 0–27; moderate severity≥11, high severity≥16], respectively. Mean self-esteem scores were 22.47 (SD = 6.26) [range 0–30]. In an age- and sex-adjusted model, we found a positive correlation between childhood trauma (CTQ scores) and depressive symptom severity [MADRS (β = 0.274; p = 0.07) and QIDS-SR (β = 0.302; p = 0.005) scores]. We detected a statistically significant correlation between physical abuse and depressive symptom severity [MADRS (β = 0.304; p = 0.03) and QIDS-SR (β = 0.362; p = 0.005) scores]. We did not observe any significant correlation between other types of trauma and depressive symptom severity. We showed that self-esteem (Rosenberg scale) mediated the effect of physical abuse (PA) on the intensity of depressive symptoms [MADRS: b = 0.318, 95% BCa C.I. [0.07, 0.62]; QIDS-SR: b = 0.177, 95% BCa C.I. [0.04, 0.37]]. Preacher & Kelly's Kappa Squared values of 19.1% (k
2 = 0.191) and 16% (k2 = 0.16), respectively for the two scales, indicate a moderate effect. Conclusion: To our knowledge, this is the first study conducted in a geriatric TRD population documenting an association between childhood trauma (mainly relating to PA) and the intensity of depressive symptoms. [ABSTRACT FROM AUTHOR]- Published
- 2021
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17. Signatures de sélection et évolution d'effecteurs candidats dans des populations pathogènes soumises aux résistances de l'hôte
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Valade, Romain, Ducasse, Aurélie, Genty, Jean-Baptiste, Maisonneuve, Brigitte, Michelmore, R., Neema, Claire, Génétique et Amélioration des Fruits et Légumes (GAFL), Institut National de la Recherche Agronomique (INRA), BIOlogie et GEstion des Risques en agriculture (BIOGER), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Unité de recherche Génétique et amélioration des fruits et légumes (GALF), and AgroParisTech-Institut National de la Recherche Agronomique (INRA)
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[SDV.SA]Life Sciences [q-bio]/Agricultural sciences ,Bremia Lactucae ,Vegetal Biology ,laitue ,lactuca sativa ,plante légumière ,marqueur ssr ,champignon phytopathogène ,gène de résistance ,pression de sélection ,Biologie végétale - Abstract
absent
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- 2011
18. Association between anhedonia and suicidal events in patients with mood disorders: A 3-year prospective study.
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Ducasse D, Dubois J, Jaussent I, Azorin JM, Etain B, Gard S, Henry C, Bougerol T, Kahn JP, Aubin V, Bellivier F, Belzeaux R, Dubertret C, Dubreucq J, Llorca PM, Loftus J, Passerieux C, Polosan M, Samalin L, Leboyer M, Yrondi A, Bennabi D, Haffen E, Maruani J, Allauze E, Camus V, D'Amato T, Doumy O, Holtzmann J, Lançon C, Moliere F, Moirand R, Richieri RM, Horn M, Schmitt L, Stephan F, Genty JB, Vaiva G, Walter M, El-Hage W, Aouizerate B, Olié E, and Courtet P
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- Humans, Mood Disorders epidemiology, Prospective Studies, Risk Factors, Suicide, Attempted, Anhedonia, Suicidal Ideation
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Background: As almost all mental disorders are associated with increased suicidal-related behavior, anhedonia might be a trans-diagnostic dimension to target for suicide prevention., Methods: For this 3-year-long prospective study, 2,839 outpatients with mood disorders were recruited. They were divided in: (a) two groups according to the occurrence or not of suicidal ideation during the follow-up, and (b) two groups according to the occurrence or not of suicide attempts during the follow-up. Anhedonia was assessed using a composite score (the French version of the 14-item Snaith-Hamilton Pleasure Scale and item 13 of the Quick Inventory of Depressive Symptomatology scale) at inclusion and at 6, 12, 24, and 36 months after inclusion., Results: Patients with mood disorders and anhedonia at least at one follow-up visit had a 1.4-fold higher risk of suicidal ideation (adjusted odds ratio = 1.35; 95% confidence interval [1.07, 1.70]), even after adjustment for confounding factors of suicide risk (i.e., bipolar or unipolar disorder, sex, age, marital status, education level, antidepressant intake, personal history of suicide attempt, at least one childhood trauma, and mean of the maximum depression score during the follow-up). Conversely, association between anhedonia and suicide attempt did not remain significant after adjustment., Conclusions: The significant association between anhedonia and suicide ideation in patients with mood disorders stresses the need of targeting hedonia in mood disorders, and of research focusing on the position to pleasure in life through eudaimonia., (© 2020 Wiley Periodicals LLC.)
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- 2021
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19. Prevalence of Metabolic Syndrome and Associated Factors in a Cohort of Individuals With Treatment-Resistant Depression: Results From the FACE-DR Study.
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Godin O, Bennabi D, Yrondi A, Richieri R, D'Amato T, Bellivier F, Bougerol T, Horn M, Camus V, Courtet P, Doumy O, Genty JB, El-Hage W, Haesebaert F, Holtzmann J, Lancon C, Leboyer M, Llorca PM, Maruani J, Molière F, Samalin L, Schmitt L, Stephan F, Vaiva G, Aouizerate MWB, and Haffen E
- Subjects
- Adult, Cohort Studies, Comorbidity, Depressive Disorder, Major diagnosis, Depressive Disorder, Major therapy, Depressive Disorder, Treatment-Resistant diagnosis, Depressive Disorder, Treatment-Resistant therapy, Female, France, Humans, Male, Metabolic Syndrome diagnosis, Metabolic Syndrome therapy, Middle Aged, Prevalence, Risk Factors, Depressive Disorder, Major epidemiology, Depressive Disorder, Treatment-Resistant epidemiology, Metabolic Syndrome epidemiology
- Abstract
Background: The aim of this study was to estimate the prevalence of metabolic syndrome (MetS) and its components in a cohort of French patients with treatment-resistant depression (TRD) and to determine correlations with sociodemographic, clinical, and treatment-related factors., Methods: From 2012 to 2018, 205 patients who met DSM-IV criteria for major depressive episode with moderate-to-severe symptoms (Montgomery-Asberg Depression Rating Scale score ≥ 20), and at least Stage II resistance according to Thase and Rush criteria were enrolled in the FondaMental Advanced Centers of Expertise in Resistant Depression (FACE-DR) cohort. Data on sociodemographic and clinical characteristics, lifestyle information, and treatment and comorbidities were collected, and a blood sample was drawn. MetS was defined according to the criteria of the International Diabetes Federation., Results: Overall, 38% of individuals with TRD met criteria for MetS. The frequency of MetS was significantly higher in men than in women only for patients aged 40 years or older (46.3% vs 35.2%, P = .0427). Moreover, whereas the management for diabetes was good, less than one-third of the patients with high blood pressure or dyslipidemia were treated for these conditions. Multivariate analysis showed that individuals with abnormal plasma c-reactive protein levels had a 3-fold increased risk (95% CI, 1.5-5.2) of having MetS, independent of other potential confounders., Conclusion: The prevalence of MetS is higher in patients with TRD than in those with other psychiatric disorders and characterized by a considerable undertreatment of some components of MetS in this population. Diagnosis and treatment of the components of MetS should be systematically performed to prevent the occurrence of cardiovascular diseases in patients with TRD. These findings highlight the need for integrated care, with more interaction and coordination between psychiatrists and primary care providers., (© Copyright 2019 Physicians Postgraduate Press, Inc.)
- Published
- 2019
- Full Text
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