Search

Your search keyword '"Genovese, Leonard D."' showing total 9 results
Start Over Author "Genovese, Leonard D."
9 results on '"Genovese, Leonard D."'

1. Cardiac Reverse Remodeling Mediated by HeartMate 3 Left Ventricular Assist Device: Comparison to Older Generation Devices

Author

Yin, Michael Yaoyao, Maneta, Eleni, Kyriakopoulos, Christos P., Michaels, Alexander T., Genovese, Leonard D., Indaram, Mahathi B., Wever-Pinzon, Omar, Singh, Ramesh, Tseliou, Eleni, Taleb, Iosif, Nemeh, Hassan W., Alharethi, Rami, Tang, Daniel G., Goldstein, Jake, Hanff, Thomas C., Selzman, Craig H., Cowger, Jennifer, Kanwar, Manreet, Shah, Palak, and Drakos, Stavros G.

Published
2024
Full Text
View/download PDF

3. Chronic Stress-Related Neural Activity Associates With Subclinical Cardiovascular Disease in Psoriasis: A Prospective Cohort Study

Author

Goyal, Aditya, Dey, Amit K., Chaturvedi, Abhishek, Elnabawi, Youssef A., Aberra, Tsion M., Chung, Jonathan H., Belur, Agastya D., Groenendyk, Jacob W., Lerman, Joseph B., Rivers, Joshua P., Rodante, Justin A., Harrington, Charlotte L., Varghese, Nevin J., Sanda, Gregory E., Baumer, Yvonne, Sorokin, Alexander V., Teague, Heather L., Genovese, Leonard D., Natarajan, Balaji, Joshi, Aditya A., Playford, Martin P., Bluemke, David A., Chen, Marcus Y., Alavi, Abass, Pitman, Roger K., Powell-Wiley, Tiffany M., Tawakol, Ahmed, Gelfand, Joel M., and Mehta, Nehal N.

Published
2020
Full Text
View/download PDF

4. Association of aortic vascular uptake of 18FDG by PET/CT and aortic wall thickness by MRI in psoriasis: a prospective observational study

Author

Groenendyk, Jacob W., Shukla, Parag, Dey, Amit K., Elnabawi, Youssef A., Aksentijevich, Milena, Choi, Harry, Genovese, Leonard D., Harrington, Charlotte L., Natarajan, Balaji, Goyal, Aditya, Reddy, Aarthi S., Rodante, Justin, Kabbany, Mohammad Tarek, Sadek, Ahmed, Al Najafi, Mina, Playford, Martin P., Joshi, Aditya A., Ahlman, Mark A., Gelfand, Joel M., Bluemke, David A., and Mehta, Nehal N.

Published
2019
Full Text
View/download PDF

6. Chronic Stress-Related Neural Activity Associates With Subclinical Cardiovascular Disease in Psoriasis: A Prospective Cohort Study

Author

Goyal, Aditya, Dey, Amit K., Chaturvedi, Abhishek, Elnabawi, Youssef A., Aberra, Tsion M., Chung, Jonathan H., Belur, Agastya D., Groenendyk, Jacob W., Lerman, Joseph B., Rivers, Joshua P., Rodante, Justin A., Harrington, Charlotte L., Varghese, Nevin J., Sanda, Gregory E., Baumer, Yvonne, Sorokin, Alexander V., Teague, Heather L., Genovese, Leonard D., Natarajan, Balaji, Joshi, Aditya A., Playford, Martin P., Bluemke, David A., Chen, Marcus Y., Alavi, Abass, Pitman, Roger K., Powell-Wiley, Tiffany M., Tawakol, Ahmed, Gelfand, Joel M., and Mehta, Nehal N.

Subjects
Adult, Male, Single Photon Emission Computed Tomography Computed Tomography, Computed Tomography Angiography, Hematopoietic System, Anti-Inflammatory Agents, Comorbidity, Coronary Angiography, Article, Fluorodeoxyglucose F18, Predictive Value of Tests, Risk Factors, Multidetector Computed Tomography, Humans, Psoriasis, Prospective Studies, Aged, Middle Aged, Amygdala, United States, Cross-Sectional Studies, Treatment Outcome, Cardiovascular Diseases, Case-Control Studies, Asymptomatic Diseases, Chronic Disease, Female, Radiopharmaceuticals, Stress, Psychological
Abstract

This study hypothesized that there is an association between chronic stress (as indexed by resting amygdalar activity [AmygA]), hematopoietic system activity (HMPA), and subclinical cardiovascular indexes (aortic vascular inflammation [VI] and noncalcified coronary plaque burden [NCB]) in psoriasis (PSO). The study also hypothesized that treatment of PSO would improve these parameters.PSO is a stress-related chronic inflammatory condition that is associated with increased prevalence of subclinical cardiovascular disease (CVD). In individuals without PSO, stress has been linked to CVD through a serial biological pathway that involves the amygdala, hematopoietic tissues, and atherosclerotic plaques.A total of 164 consecutive patients with PSO and 47 healthy volunteers underwent 18-fluorodeoxyglucose positron emission tomography/computed tomography scans for assessment of AmygA, HMPA, and VI, as well as coronary computed tomography angiography scans for quantifying NCB. Furthermore, a consecutive subset of 30 patients with severe PSO (Psoriasis Area Severity Index Score10) were followed at 1 year to assess the relationship between skin disease improvement and AmygA, HMPA, VI, and NCB.The PSO cohort was middle-aged (mean age: 50 years), had low cardiovascular risk (Framingham risk score: median: 3) and had mild to moderate PSO activity (median Psoriasis Area Severity Index Score: 5.6). AmygA was higher in patients with PSO compared to volunteer participants. AmygA was associated with HMPA (bone marrow activity: β = 0.20, p = 0.01) and subclinical CVD (VI: β = 0.31, p 0.001; NCB: β = 0.27, p 0.001) The AmygA-CVD association was in part mediated by HMPA (VI: 20.9%, NCB: 36.7%). Following 1 year of PSO treatment in those with severe disease, improvement in skin disease was accompanied by a reduction in AmygA, bone marrow activity, and VI, with no progression of NCB.In PSO, a chronic inflammatory disease state, AmygA, which is a manifestation of chronic stress, substantially contributes to the risk of subclinical CVD. Additional studies that use psychometric measures of stress are required to explore therapeutic impact.

Published
2018

7. Abstract 549: Improvement in Large Density HDL Particle Number by NMR is Associated with Reduction in Coronary Soft Plaque Burden by Coronary Computed Tomography Angiography in Psoriasis

Author

Elnabawi, Yousssef A, primary, Dey, Amit K, additional, Goyal, Aditya, additional, Groenendyk, Jacob W, additional, Genovese, Leonard D, additional, Belur, Agastya D, additional, Rodante, Justin A, additional, Chen, Marcus Y, additional, Bluemke, David A, additional, Remaley, Alan T, additional, Playford, Martin P, additional, and Mehta, Nehal N, additional

Published
2018
Full Text
View/download PDF

8. Association of aortic vascular uptake of 18FDG by PET/CT and aortic wall thickness by MRI in psoriasis: a prospective observational study.

Author

Groenendyk, Jacob W., Shukla, Parag, Dey, Amit K., Elnabawi, Youssef A., Aksentijevich, Milena, Choi, Harry, Genovese, Leonard D., Harrington, Charlotte L., Natarajan, Balaji, Goyal, Aditya, Reddy, Aarthi S., Rodante, Justin, Kabbany, Mohammad Tarek, Sadek, Ahmed, Al Najafi, Mina, Playford, Martin P., Joshi, Aditya A., Ahlman, Mark A., Gelfand, Joel M., and Bluemke, David A.

Subjects
PSORIASIS, LONGITUDINAL method, WAIST-hip ratio, AUTORADIOGRAPHY, FLUORODEOXYGLUCOSE F18, CAROTID intima-media thickness, SCIENTIFIC observation
Abstract

Background: The contribution of inflammation to the incidence of cardiovascular disease (CVD) has been increasingly recognized in recent years. We investigated the relationship of aortic vascular uptake of 18F-FDG by PET/CT and aortic wall thickness (AWT) by MRI in psoriasis, a chronic inflammatory disease with increased incidence of CVD. One hundred sixty-five patients with plaque psoriasis participated in an ongoing longitudinal cohort study. Subclinical atherosclerosis was assessed as aortic uptake of 18F-FDG by PET/CT reported as target-to-background ratio (TBR) and AWT by MRI reported as maximal thickness. Results: Patients with psoriasis were middle aged, predominantly male, and had mild CV risk by traditional risk factors. Psoriasis severity as measured by PASI score was a notable determinant of AWT (ρ = 0.20, p = 0.01). Moreover, aortic vascular uptake of 18F-FDG associated with AWT by MRI at baseline in unadjusted analysis (β = 0.27 p = 0.001) and following adjustment for traditional cardiovascular risk factors, waist-to-hip ratio, and statin use (β = 0.21 p = 0.01). Finally, following 1 year of psoriasis treatment, a decrease in aortic vascular uptake of 18F-FDG was associated with a reduction in AWT in fully adjusted models (β = 0.33, p = 0.02). Conclusion: In conclusion, we demonstrate that psoriasis severity and aortic vascular uptake of 18F-FDG in the aorta were associated with AWT. Following treatment of psoriasis, a decrease in aortic vascular uptake of 18F-FDG was associated with a reduction in AWT at 1 year. These findings suggest that aortic vascular uptake of 18F-FDG is associated with early evidence of vascular disease assessed by aortic wall thickness. Prospective studies in larger populations including other inflammatory diseases are warranted. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results