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2. S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (EADV)

Author

Antiga, Emiliano, Bech, Rikke, Maglie, Roberto, Genovese, Giovanni, Borradori, Luca, Bockle, Barbara, Caproni, Marzia, Caux, Frédéric, Chandran, Nisha Suyien, Corrà, Alberto, D'Amore, Francesco, Daneshpazhooh, Maryam, De, Dipankar, Didona, Dario, Dmochowski, Marian, Drenovska, Kossara, Ehrchen, Jan, Feliciani, Claudio, Goebeler, Matthias, Groves, Richard, Günther, Claudia, Handa, Sanjeev, Hofmann, Silke C, Horvath, Barbara, Ioannidis, Dimitrios, Jedlickova, Hana, Kowalewski, Cezary, Kridin, Khalaf, Joly, Pascal, Lim, Yen Loo, Marinovic, Branka, Maverakis, Emanual, Meijer, Joost, Patsatsi, Aikaterini, Pincelli, Carlo, Prost, Catherine, Setterfield, Jane, Sprecher, Eli, Skiljevic, Dusan, Tasanen, Kaisa, Uzun, Soner, Van Beek, Nina, Vassileva, Snejina, Vorobyev, Artem, Vujic, Igor, Wang, Gang, Wang, Mingyue, Wozniak, Katarzyna, Yayli, Savas, Zambruno, Giovanna, Hashimoto, Takashi, Schmidt, Enno, Mascarò, José Manuel, and Marzano, Angelo Valerio

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Hematology, Autoimmune Disease, Animals, Rats, Autoimmune Diseases, Neoplasms, Paraneoplastic Syndromes, Paraneoplastic Syndromes, Nervous System, Societies, Medical, Dermatology & Venereal Diseases, Clinical sciences
Abstract

BackgroundParaneoplastic pemphigus (PNP), also called paraneoplastic autoimmune multiorgan syndrome (PAMS), is a rare autoimmune disease with mucocutaneous and multi-organ involvement. PNP/PAMS is typically associated with lymphoproliferative or haematological malignancies, and less frequently with solid malignancies. The mortality rate of PNP/PAMS is elevated owing to the increased risk of severe infections and disease-associated complications, such as bronchiolitis obliterans.ObjectivesThese guidelines summarize evidence-based and expert-based recommendations (S2k level) for the clinical characterization, diagnosis and management of PNP/PAMS. They have been initiated by the Task Force Autoimmune Blistering Diseases of the European Academy of Dermatology and Venereology with the contribution of physicians from all relevant disciplines. The degree of consent among all task force members was included.ResultsChronic severe mucositis and polymorphic skin lesions are clue clinical characteristics of PNP/PAMS. A complete assessment of the patient with suspected PNP/PAMS, requiring histopathological study and immunopathological investigations, including direct and indirect immunofluorescence, ELISA and, where available, immunoblotting/immunoprecipitation, is recommended to achieve a diagnosis of PNP/PAMS. Detection of anti-envoplakin antibodies and/or circulating antibodies binding to the rat bladder epithelium at indirect immunofluorescence is the most specific tool for the diagnosis of PNP/PAMS in a patient with compatible clinical and anamnestic features. Treatment of PNP/PAMS is highly challenging. Systemic steroids up to 1.5 mg/kg/day are recommended as first-line option. Rituximab is also recommended in patients with PNP/PAMS secondary to lymphoproliferative conditions but might also be considered in cases of PNP/PAMS associated with solid tumours. A multidisciplinary approach involving pneumologists, ophthalmologists and onco-haematologists is recommended for optimal management of the patients.ConclusionsThese are the first European guidelines for the diagnosis and management of PNP/PAMS. Diagnostic criteria and therapeutic recommendations will require further validation by prospective studies.

Published
2023

7. Gliptin-associated bullous pemphigoid shows peculiar features of anti-BP180 and -BP230 humoral response: Results of a multicenter study

Author

Salemme, Adele, Fania, Luca, Scarabello, Alessandra, Caproni, Marzia, Marzano, Angelo Valerio, Cozzani, Emanuele, Feliciani, Claudio, De Simone, Clara, Papini, Manuela, Satta, Rosanna Rita, Parodi, Aurora, Mariotti, Feliciana, Lechiancole, Stefania, Genovese, Giovanni, Passarelli, Francesca, Festa, Francesca, Bellei, Barbara, Provini, Alessia, Sordi, Donatella, Pallotta, Sabatino, Abeni, Damiano, Mazzanti, Cinzia, Didona, Biagio, and Di Zenzo, Giovanni

Published
2022
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11. The clinical spectrum of COVID-19–associated cutaneous manifestations: An Italian multicenter study of 200 adult patients

Author

Marzano, Angelo Valerio, Genovese, Giovanni, Moltrasio, Chiara, Gaspari, Valeria, Vezzoli, Pamela, Maione, Vincenzo, Misciali, Cosimo, Sena, Paolo, Patrizi, Annalisa, Offidani, Annamaria, Quaglino, Pietro, Arco, Renato, Caproni, Marzia, Rovesti, Miriam, Bordin, Giorgio, Recalcati, Sebastiano, Potenza, Concetta, Guarneri, Claudio, Fabbrocini, Gabriella, Tomasini, Carlo, Sorci, Mariarita, Lombardo, Maurizio, Gisondi, Paolo, Conti, Andrea, Casazza, Giovanni, Peris, Ketty, Calzavara-Pinton, Piergiacomo, and Berti, Emilio

Published
2021
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13. An emerging role for BAG3 in gynaecological malignancies

Author

De Marco, Margot, Falco, Antonia, Iaccarino, Roberta, Raffone, Antonio, Mollo, Antonio, Guida, Maurizio, Rosati, Alessandra, Chetta, Massimiliano, Genovese, Giovanni, De Caro, Francesco, Capunzo, Mario, Turco, Maria Caterina, Uversky, Vladimir N., and Marzullo, Liberato

Published
2021
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14. Safety of Adjuvanted Recombinant Herpes Zoster Virus Vaccination in Fragile Populations: An Observational Real-Life Study.

Author

Costantino, Maria, Giudice, Valentina, Moccia, Giuseppina, Longanella, Walter, Caruccio, Simona, Tremiterra, Giuliana, Sinopoli, Pio, Benvenuto, David, Serio, Bianca, Malatesta, Francesca, Pecoraro, Nadia, Vozzella, Emilia Anna, Rossiello, Riccardo, Genovese, Giovanni, and De Caro, Francesco

Subjects
HERPES zoster vaccines, VARICELLA-zoster virus, VACCINE hesitancy, COMMUNICABLE diseases, TRANSPLANTATION of organs, tissues, etc.
Abstract

Background: Vaccination is the most effective strategy for preventing infectious diseases and related complications, and proving its efficacy is crucial for its success and adherence, especially for newly introduced vaccines, such as adjuvanted recombinant herpes zoster virus vaccination (RZV). In this observational real-life study, we recorded adverse effects following immunization (AEFIs) after RZV administration in frail populations. Methods: A total of 271 subjects underwent RZV at Vaccination Center, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy. Most subjects were solid organ transplant recipients (kidney, 77.1%; liver, 4.8%). Demographics, clinical data, and AEFIs (type, duration, and medications used) were recorded. Results: Overall, 37% of participants reported at least one AEFI following the first dose, predominantly pain at the injection site (60%), while 41% did so after the second dose (pain at the injection site in 62% of cases). Medications were more frequently used for AEFI treatment after the second dose (28%) rather than after the first dose (13%) (p = 0.01). After stratification by sex, females experienced AEFIs more frequently than males, particularly local skin reactions. Conclusions: Our study added evidence of safety and tolerability of the adjuvanted recombinant RZV in frail adults. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Cognitive effects of brief and intensive neurofeedback treatment in schizophrenia: a single center pilot study.

Author

Turiaco, Fabrizio, Iannuzzo, Fiammetta, Genovese, Giovanni, Lombardo, Clara, Silvestri, Maria Catena, Celebre, Laura, Muscatello, Maria Rosaria Anna, and Bruno, Antonio

Abstract

Background: Schizophrenia is characterized by significant cognitive impairments and affects up to 98% of patients. Neurofeedback (NF) offers a means to modulate neural network function through cognitive processes such as learning and memorization, with documented structural changes in the brain, most notably an increase in grey matter volume in targeted regions. Methods: The present 2-week, open-label, preliminary study aims to evaluate the efficacy on cognition of an adjunctive short and intensive (8 daily sessions lasting 30 minutes) alpha/theta NF training in a sample of subjects affected by schizophrenia on stabilized treatment with atypical antipsychotic drugs. The efficacy was measured at baseline and at the end of the study by the Brief Neuropsychological Examination 2 (ENB 2), the Mini Mental State Examination (MMSE), and the Stroop color-word interference test; the clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). Results: A final sample of nine patients completed the study. Regarding the cognitive performance, at the final assessment (week 2), the NF treatment significantly improved the performance in the "Story Recall Immediate" (p = 0.024), "Story Recall Delayed" (p = 0.007), "Interference Memory 30 s" (p = 0.024), "Clock Test" (p = 0.014) sub-tests, and the ENB2 Total Score (p = 0.007). Concerning the clinical symptoms, no significant changes were observed in the PANSS subscales and the PANSS Total score. Conclusions: NF could represent an adjunctive treatment strategy in the therapeutic toolbox for schizophrenia cognitive symptoms. [ABSTRACT FROM AUTHOR]

Published
2024
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25. A sweet fever

Author

Tiraboschi, Silvia, Marzano, Angelo Valerio, Lombardi, Rosa, Genovese, Giovanni, Boccoli, Giovanni, Fargion, Silvia, and Fracanzani, Anna Ludovica

Published
2019
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26. Corrigendum: S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (EADV)

Author

Antiga, Emiliano, primary, Bech, Rikke, additional, Maglie, Roberto, additional, Genovese, Giovanni, additional, Borradori, Luca, additional, Bockle, Barbara, additional, Caproni, Marzia, additional, Caux, Frédéric, additional, Chandran, Nisha Suyien, additional, Corrà, Alberto, additional, D'Amore, Francesco, additional, Daneshpazhooh, Maryam, additional, De, Dipankar, additional, Didona, Dario, additional, Dmochowski, Marian, additional, Drenovska, Kossara, additional, Ehrchen, Jan, additional, Feliciani, Claudio, additional, Goebeler, Matthias, additional, Groves, Richard, additional, Günther, Claudia, additional, Handa, Sanjeev, additional, Hofmann, Silke C., additional, Horvath, Barbara, additional, Ioannidis, Dimitrios, additional, Jedlickova, Hana, additional, Kowalewski, Cezary, additional, Kridin, Khalaf, additional, Joly, Pascal, additional, Lim, Yen Loo, additional, Marinovic, Branka, additional, Maverakis, Emanual, additional, Meijer, Joost, additional, Patsatsi, Aikaterini, additional, Pincelli, Carlo, additional, Prost, Catherine, additional, Setterfield, Jane, additional, Sprecher, Eli, additional, Skiljevic, Dusan, additional, Tasanen, Kaisa, additional, Uzun, Soner, additional, Van Beek, Nina, additional, Vassileva, Snejina, additional, Vorobyev, Artem, additional, Vujic, Igor, additional, Wang, Gang, additional, Wang, Mingyue, additional, Wozniak, Katarzyna, additional, Yayli, Savas, additional, Zambruno, Giovanna, additional, Hashimoto, Takashi, additional, Schmidt, Enno, additional, Mascarò, José Manuel, additional, and Marzano, Angelo Valerio, additional

Published
2023
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32. S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (EADV)

Author

Yaylı, Savaş (ORCID 0000-0001-9402-940X & YÖK ID 151352), Antiga, Emiliano; Bech, Rikke; Maglie, Roberto; Genovese, Giovanni; Borradori, Luca; Bockle, Barbara; Caproni, Marzia; Caux, Frédéric; Chandran, Nisha Suyien; Corrà, Alberto; D'Amore, Francesco; Daneshpazhooh, Maryam; De, Dipankar; Didona, Dario; Dmochowski, Marian; Drenovska, Kossara; Ehrchen, Jan; Feliciani, Claudio; Goebeler, Matthias; Groves, Richard; Günther, Claudia; Handa, Sanjeev; Hofmann, Silke C.; Horvath, Barbara; Ioannidis, Dimitrios; Jedlickova, Hana; Kowalewski, Cezary; Kridin, Khalaf; Joly, Pascal; Lim, Yen Loo; Marinovic, Branka; Maverakis, Emanual; Meijer, Joost; Patsatsi, Aikaterini; Pincelli, Carlo; Prost, Catherine; Setterfield, Jane; Sprecher, Eli; Skiljevic, Dusan; Tasanen, Kaisa; Uzun, Soner; Van Beek, Nina; Vassileva, Snejina; Vorobyev, Artem; Vujic, Igor; Wang, Gang; Wang, Mingyue; Wozniak, Katarzyna; Zambruno, Giovanna; Hashimoto, Takashi; Schmidt, Enno; Mascarò, José Manuel; Marzano, Angelo Valerio, School of Medicine, Yaylı, Savaş (ORCID 0000-0001-9402-940X & YÖK ID 151352), Antiga, Emiliano; Bech, Rikke; Maglie, Roberto; Genovese, Giovanni; Borradori, Luca; Bockle, Barbara; Caproni, Marzia; Caux, Frédéric; Chandran, Nisha Suyien; Corrà, Alberto; D'Amore, Francesco; Daneshpazhooh, Maryam; De, Dipankar; Didona, Dario; Dmochowski, Marian; Drenovska, Kossara; Ehrchen, Jan; Feliciani, Claudio; Goebeler, Matthias; Groves, Richard; Günther, Claudia; Handa, Sanjeev; Hofmann, Silke C.; Horvath, Barbara; Ioannidis, Dimitrios; Jedlickova, Hana; Kowalewski, Cezary; Kridin, Khalaf; Joly, Pascal; Lim, Yen Loo; Marinovic, Branka; Maverakis, Emanual; Meijer, Joost; Patsatsi, Aikaterini; Pincelli, Carlo; Prost, Catherine; Setterfield, Jane; Sprecher, Eli; Skiljevic, Dusan; Tasanen, Kaisa; Uzun, Soner; Van Beek, Nina; Vassileva, Snejina; Vorobyev, Artem; Vujic, Igor; Wang, Gang; Wang, Mingyue; Wozniak, Katarzyna; Zambruno, Giovanna; Hashimoto, Takashi; Schmidt, Enno; Mascarò, José Manuel; Marzano, Angelo Valerio, and School of Medicine

Abstract

Background: paraneoplastic pemphigus (PNP), also called paraneoplastic autoimmune multiorgan syndrome (PAMS), is a rare autoimmune disease with mucocutaneous and multi-organ involvement. PNP/PAMS is typically associated with lymphoproliferative or haematological malignancies, and less frequently with solid malignancies. The mortality rate of PNP/PAMS is elevated owing to the increased risk of severe infections and disease-associated complications, such as bronchiolitis obliterans. Objectives: these guidelines summarize evidence-based and expert-based recommendations (S2k level) for the clinical characterization, diagnosis and management of PNP/PAMS. They have been initiated by the Task Force Autoimmune Blistering Diseases of the European Academy of Dermatology and Venereology with the contribution of physicians from all relevant disciplines. The degree of consent among all task force members was included. Results: chronic severe mucositis and polymorphic skin lesions are clue clinical characteristics of PNP/PAMS. A complete assessment of the patient with suspected PNP/PAMS, requiring histopathological study and immunopathological investigations, including direct and indirect immunofluorescence, ELISA and, where available, immunoblotting/immunoprecipitation, is recommended to achieve a diagnosis of PNP/PAMS. Detection of anti-envoplakin antibodies and/or circulating antibodies binding to the rat bladder epithelium at indirect immunofluorescence is the most specific tool for the diagnosis of PNP/PAMS in a patient with compatible clinical and anamnestic features. Treatment of PNP/PAMS is highly challenging. Systemic steroids up to 1.5 mg/kg/day are recommended as first-line option. Rituximab is also recommended in patients with PNP/PAMS secondary to lymphoproliferative conditions but might also be considered in cases of PNP/PAMS associated with solid tumours. A multidisciplinary approach involving pneumologists, ophthalmologists and onco-haematologists is recommended f, Open Access Funding provided by Universita degli Studi di Firenze within the CRUI-CARE Agreement.

Published
2023

33. Hyper-IgD syndrome and hidradenitis suppurativa: An intriguing link.

Author

Calabrese, Laura, Vitale, Antonio, Moltrasio, Chiara, Genovese, Giovanni, Romagnuolo, Maurizio, Marzano, Angelo V., Maglie, Roberto, Rubegni, Pietro, and Cantarini, Luca

Subjects
HIDRADENITIS suppurativa, SYNDROMES, BEHCET'S disease, MEDICAL sciences, MEVALONATE kinase
Abstract

This article discusses the case of a 44-year-old woman with hyperimmunoglobulinemia D periodic fever syndrome (HIDS) who also developed hidradenitis suppurativa (HS). HIDS is a rare autoinflammatory disorder caused by mutations in the MVK gene, while HS is a chronic skin disease characterized by recurrent nodules, abscesses, and scars. The article suggests that the coexistence of HIDS and HS may provide insights into the molecular pathways underlying autoinflammation and could potentially lead to new therapeutic strategies for both conditions. [Extracted from the article]

Published
2024
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34. Hidradenitis suppurativa and adalimumab in the COVID-19 era

Author

Marzano, Angelo Valerio, Moltrasio, Chiara, Genovese, Giovanni, Muratori, Simona, Dapavo, Paolo, Fabbrocini, Gabriella, Patrizi, Annalisa, Sechi, Andrea, Micali, Giuseppe, Pellegrino, Michele, Gisondi, Paolo, Dini, Valentina, Bianchi, Luca, Fania, Luca, Offidani, Annamaria, Prignano, Francesca, Atzori, Laura, Miraglia, Emanuele, Cannavò, Serafinella Patrizia, Bettoli, Vincenzo, Stingeni, Luca, Balestri, Riccardo, Venturini, Marina, and Peris, Ketty

Published
2020
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41. A LC-MS/MS based methodology for the environmental monitoring of healthcare settings contaminated with antineoplastic agents

Author

Charlier, Bruno, primary, Coglianese, Albino, additional, De Rosa, Federica, additional, Cozzolino, Armando, additional, Boccia, Giovanni, additional, Borrelli, Anna, additional, Capunzo, Mario, additional, Genovese, Giovanni, additional, De Caro, Francesco, additional, Filippelli, Amelia, additional, Dal Piaz, Fabrizio, additional, and Izzo, Viviana, additional

Published
2023
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43. SARS-CoV-2 Detection by Digital Polymerase Chain Reaction and Immunohistochemistry in Skin Biopsies from 52 Patients with Different COVID-19-Associated Cutaneous Phenotypes

Author

Marzano, Angelo V., primary, Moltrasio, Chiara, additional, Genovese, Giovanni, additional, De Andrea, Marco, additional, Caneparo, Valeria, additional, Vezzoli, Pamela, additional, Morotti, Denise, additional, Sena, Paolo, additional, Venturini, Marina, additional, Battocchio, Simonetta, additional, Caputo, Valentina, additional, Rizzo, Nathalie, additional, Maronese, Carlo Alberto, additional, Venegoni, Luigia, additional, Boggio, Francesca Laura, additional, Rongioletti, Franco, additional, Calzavara-Pinton, Piergiacomo, additional, and Berti, Emilio, additional

Published
2023
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44. S2K guidelines on the management of paraneoplastic pemphigus/ paraneoplastic autoim-mune multiorgan syndrome initiated by the European Academy of Dermatology and Vene-reology (EADV)

Author

Antiga, Emiliano, Bech, Rikke, Maglie, Roberto, Genovese, Giovanni, Borradori, Luca, Bockle, Barbara, Caproni, Marzia, Caux, Frederic, Chandran, Nisha S., Corrà, Alberto, d'Amore, Francesco Annibale, Daneshpazhoo, Maryam, Dipankar, D., Didona, Dario, Drenovska, Marian D. K., Ehrchen, Jan, Feliciani, Claudio, Goebeler, Matthias, Günther, Claudia, Handa, Sanjeev, Hofmann, Silke, Horvath, Barbara, Ioannidis, Dimitrios, Jedlickova, Hana, Kowaleski, Cezary, Kridin, Khalaf, Joly, Pascal, Loo, Lim Yen, Marinovic, Branka, Maverakis, Emmanual, Meijer, Joost, Patsatsi, Aikaterini, Pincelli, Carlo, Prost, Catherine, Setterfield, Jane, Specher, Eli, Skiljevic, Dusan, Tasanen-Maatta, Kaisa, Uzun, Soner, Beek, Nina Van, Vassileva, Snejina, Vorobyev, Artem, Vujic, Igor, Wang, Gang, Wang, Mingyue, Yayli, Katarzyna W. S., Zambruno, Giovanna, Hashimoto, Takashi, Schmidt, Enno, Mascarò, José M., and Marzano, Angelo Valerio

Published
2023

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