23 results on '"Genovese, Danilo"'
Search Results
2. Long-term safety and efficacy of frameless subthalamic deep brain stimulation in Parkinson’s disease
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Genovese, Danilo, Bove, Francesco, Rigon, Leonardo, Tufo, Tommaso, Izzo, Alessandro, Calabresi, Paolo, Bentivoglio, Anna Rita, and Piano, Carla
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- 2024
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3. STN-DBS does not increase the risk of sialorrhea in patients with advanced Parkinson’s disease
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Bove, Francesco, Genovese, Danilo, Petracca, Martina, Tufo, Tommaso, Pisani, Danila, Lo Monaco, Maria Rita, Bentivoglio, Anna Rita, Calabresi, Paolo, and Piano, Carla
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- 2022
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4. Movement disorders following mechanical thrombectomy resulting in ischemic lesions of the basal ganglia: An emerging clinical entity
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Rigon, Leonardo, primary, Genovese, Danilo, additional, Piano, Carla, additional, Brunetti, Valerio, additional, Guglielmi, Valeria, additional, Cimmino, Angelo Tiziano, additional, Scala, Irene, additional, Citro, Salvatore, additional, Bentivoglio, Anna Rita, additional, Rollo, Eleonora, additional, Di Iorio, Riccardo, additional, Broccolini, Aldobrando, additional, Morosetti, Roberta, additional, Monforte, Mauro, additional, Frisullo, Giovanni, additional, Caliandro, Pietro, additional, Pedicelli, Alessandro, additional, Caricato, Anselmo, additional, Masone, Giovanna, additional, Calabresi, Paolo, additional, and Marca, Giacomo Della, additional
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- 2024
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5. Movement disorders following mechanical thrombectomy resulting in ischemic lesions of the basal ganglia: An emerging clinical entity
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Rigon, Leonardo, Genovese, Danilo, Piano, Carla, Brunetti, Valerio, Guglielmi, Valeria, Cimmino, Angelo Tiziano, Scala, Irene, Citro, Salvatore, Bentivoglio, Anna Rita, Rollo, Eleonora, Di Iorio, Riccardo, Broccolini, Aldobrando, Morosetti, Roberta, Monforte, Mauro, Frisullo, Giovanni, Caliandro, Pietro, Pedicelli, Alessandro, Caricato, Anselmo, Masone, Giovanna, Calabresi, Paolo, Della Marca, Giacomo, Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Broccolini, Aldobrando (ORCID:0000-0001-8295-9271), Caliandro, Pietro (ORCID:0000-0002-1190-4879), Pedicelli, Alessandro (ORCID:0000-0002-2558-8838), Caricato, Anselmo (ORCID:0000-0001-5929-120X), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Marca, Giacomo Della (ORCID:0000-0001-6914-799X), Rigon, Leonardo, Genovese, Danilo, Piano, Carla, Brunetti, Valerio, Guglielmi, Valeria, Cimmino, Angelo Tiziano, Scala, Irene, Citro, Salvatore, Bentivoglio, Anna Rita, Rollo, Eleonora, Di Iorio, Riccardo, Broccolini, Aldobrando, Morosetti, Roberta, Monforte, Mauro, Frisullo, Giovanni, Caliandro, Pietro, Pedicelli, Alessandro, Caricato, Anselmo, Masone, Giovanna, Calabresi, Paolo, Della Marca, Giacomo, Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Broccolini, Aldobrando (ORCID:0000-0001-8295-9271), Caliandro, Pietro (ORCID:0000-0002-1190-4879), Pedicelli, Alessandro (ORCID:0000-0002-2558-8838), Caricato, Anselmo (ORCID:0000-0001-5929-120X), Calabresi, Paolo (ORCID:0000-0003-0326-5509), and Marca, Giacomo Della (ORCID:0000-0001-6914-799X)
- Abstract
Background and purposePost-stroke movement disorders (PMDs) following ischemic lesions of the basal ganglia (BG) are a known entity, but data regarding their incidence are lacking. Ischemic strokes secondary to proximal middle cerebral artery (MCA) occlusion treated with thrombectomy represent a model of selective damage to the BG. The aim of this study was to assess the prevalence and features of movement disorders after selective BG ischemia in patients with successfully reperfused acute ischemic stroke (AIS).MethodsWe enrolled 64 consecutive subjects with AIS due to proximal MCA occlusion treated with thrombectomy. Patients were clinically evaluated by a movement disorders specialist for PMDs onset at baseline, and after 6 and 12 months.ResultsNone of the patients showed an identifiable movement disorder in the subacute phase of the stroke. At 6 and 12 months, respectively, 7/25 (28%) and 7/13 (53.8%) evaluated patients developed PMDs. The clinical spectrum of PMDs encompassed parkinsonism, dystonia and chorea, either isolated or combined. In most patients, symptoms were contralateral to the lesion, although a subset of patients presented with bilateral involvement and prominent axial signs.ConclusionPost-stroke movement disorders are not uncommon in long-term follow-up of successfully reperfused AIS. Follow-up conducted by a multidisciplinary team is strongly advisable in patients with selective lesions of the BG after AIS, even if asymptomatic at discharge.
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- 2024
6. Prevalence of Obsessive-Compulsive Symptoms in Elderly Parkinson Disease Patients: A Case-Control Study
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Lo Monaco, Maria Rita, Di Stasio, Enrico, Zuccalà, Giuseppe, Petracca, Martina, Genovese, Danilo, Fusco, Domenico, Silveri, Maria Caterina, Liperoti, Rosa, Ricciardi, Diego, Cipriani, Maria Camilla, Laudisio, Alice, and Bentivoglio, Anna Rita
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- 2020
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7. Long-term safety and efficacy of frameless subthalamic deep brain stimulation in Parkinson’s disease
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Genovese, Danilo, primary, Bove, Francesco, additional, Rigon, Leonardo, additional, Tufo, Tommaso, additional, Izzo, Alessandro, additional, Calabresi, Paolo, additional, Bentivoglio, Anna Rita, additional, and Piano, Carla, additional
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- 2023
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8. Basal ganglia ischaemic infarction after thrombectomy: cognitive impairment at acute stage
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Guglielmi, Valeria, primary, Quaranta, Davide, additional, Masone Iacobucci, Giovanna, additional, Citro, Salvatore, additional, Scala, Irene, additional, Genovese, Danilo, additional, Brunetti, Valerio, additional, Marra, Camillo, additional, Calabresi, Paolo, additional, and Della Marca, Giacomo, additional
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- 2023
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9. Art therapy as a comprehensive complementary treatment for Parkinson’s disease
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Ettinger, Tom, primary, Berberian, Marygrace, additional, Acosta, Ikuko, additional, Cucca, Alberto, additional, Feigin, Andrew, additional, Genovese, Danilo, additional, Pollen, Travis, additional, Rieders, Julianne, additional, Kilachand, Rohita, additional, Gomez, Clara, additional, Kaimal, Girija, additional, Biagioni, Milton, additional, Di Rocco, Alessandro, additional, Ghilardi, Felice M., additional, and Rizzo, John-Ross, additional
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- 2023
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10. Basal ganglia ischaemic infarction after thrombectomy: cognitive impairment at acute stage
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Guglielmi, Valeria, Quaranta, Davide, Masone Iacobucci, Giovanna, Citro, Salvatore, Scala, Irene, Genovese, Danilo, Brunetti, Valerio, Marra, Camillo, Calabresi, Paolo, Della Marca, Giacomo, Marra, Camillo (ORCID:0000-0003-3994-4044), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Della Marca, Giacomo (ORCID:0000-0001-6914-799X), Guglielmi, Valeria, Quaranta, Davide, Masone Iacobucci, Giovanna, Citro, Salvatore, Scala, Irene, Genovese, Danilo, Brunetti, Valerio, Marra, Camillo, Calabresi, Paolo, Della Marca, Giacomo, Marra, Camillo (ORCID:0000-0003-3994-4044), Calabresi, Paolo (ORCID:0000-0003-0326-5509), and Della Marca, Giacomo (ORCID:0000-0001-6914-799X)
- Abstract
Background and purpose: After successful mechanical thrombectomy for middle cerebral artery occlusion, basal ganglia infarction is commonly detectable. Whilst the functional outcome of these patients is often good, less knowledge is available about the cognitive outcome. The aim of our study was to assess the presence of cognitive impairment within 1 week after thrombectomy.Methods: In all, 43 subjects underwent a general cognitive assessment using the Montreal Cognitive Assessment and an extensive battery of tests. Patients were classified as cognitively impaired (CImp) or not (noCImp) according to a Montreal Cognitive Assessment score below 18.Results: Cognitively impaired and noCImp subjects did not differ either in their National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) at admittance, or in their Fazekas score and Alberta Stroke Program Early Computed Tomography Score. At discharge, CImp subjects showed higher scores than noCImp subjects on NIHSS (p = 0.002) and mRS (p < 0.001). The percentage of pathological performances on each neuropsychological test in the whole sample and in CImp and noCImp patients shows a similar cognitive profile between the groups.Conclusions: Some patients who underwent thrombectomy experienced a detectable cognitive impairment that probably led to worse NIHSS and mRS. The neuropsychological profile of such cognitive impairment at the acute stage consists of wide deficits in numerous cognitive domains, suggesting that basal ganglia damage may lead to complex functional impairments.
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- 2023
11. Cerebral Fat Embolism: A Rare Cause of Juvenile Stroke
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Nicoletti, Tommaso, Genovese, Danilo, Di Iorio, Riccardo, and Marca, Giacomo
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Fat embolism -- Case studies -- Diagnosis -- Complications and side effects ,Pediatric research ,Neuroimaging -- Methods ,Cerebral embolism -- Case studies -- Diagnosis -- Complications and side effects ,Stroke -- Case studies -- Diagnosis -- Causes of ,Health - Abstract
Byline: Tommaso. Nicoletti, Danilo. Genovese, Riccardo. Di Iorio, Giacomo. Marca A 16-year-old boy presented with encephalopathy and respiratory distress three days after a long-bone fracture repair. Head computed tomography (CT) [...]
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- 2020
12. Developments in the mechanistic understanding and clinical application of deep brain stimulation for Parkinson’s disease
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Bove, Francesco, primary, Genovese, Danilo, additional, and Moro, Elena, additional
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- 2022
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13. Heart Rate Variability during wake and sleep in Huntington’s Disease patients. An observational, cross-sectional, cohort study.
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Marotta, Jessica, primary, Piano, Carla, additional, BRUNETTI, VALERIO, additional, Genovese, Danilo, additional, Bentivoglio, Anna Rita, additional, Calabresi, Paolo, additional, Cortelli, Pietro, additional, and Della Marca, Giacomo, additional
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- 2021
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14. Motor and neurophysiological features of sleep in Huntington disease: A single-center, prospective, cross-sectional, cohort study
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Genovese, Danilo, Piano, Carla, Brunetti, Valerio, Marotta, Jessica, Losurdo, Anna, Bentivoglio, Anna Rita, Calabresi, Paolo, Cortelli, Pietro, and Marca, Giacomo Della
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- 2021
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15. Heart Rate Variability during wake and sleep in Huntington's Disease patients. An observational, cross-sectional, cohort study
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Marotta, Jessica, Piano, Carla, Brunetti, Valerio, Genovese, Danilo, Bentivoglio, Anna Rita, Calabresi, Paolo, Cortelli, P., Della Marca, Giacomo, Marotta J., Piano C., Brunetti V., Genovese D., Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Calabresi P. (ORCID:0000-0003-0326-5509), Della Marca G. (ORCID:0000-0001-6914-799X), Marotta, Jessica, Piano, Carla, Brunetti, Valerio, Genovese, Danilo, Bentivoglio, Anna Rita, Calabresi, Paolo, Cortelli, P., Della Marca, Giacomo, Marotta J., Piano C., Brunetti V., Genovese D., Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Calabresi P. (ORCID:0000-0003-0326-5509), and Della Marca G. (ORCID:0000-0001-6914-799X)
- Abstract
Introduction Autonomic dysfunction has been reported as one of non-motor manifestations of both pre-symptomatic and manifest Huntington's Disease (HD). The aim of our study was to evaluate heart rate variability (HRV) during wake and sleep in a cohort of patients with manifest HD. Methods Thirty consecutive patients with manifest HD were enrolled, 14 men and 16 women, mean age 57.3±12.2 years. All patients underwent full-night attended video-polysomnography. HRV was analyzed during wake, NREM and REM sleep, in time and frequency domain. Results were compared with a control group of healthy volunteers matched for age and sex. Results During wake HD patients presented significantly higher mean heart rate than controls (72.4±9.6 vs 58.1±7.3 bpm; p<0.001). During NREM sleep, HD patients showed higher mean heart rate (65.6±11.1 vs 48.8±4.6 bpm; p<0.001) and greater Low Frequency (LF) component of HRV (52.9±22.6 vs 35.5±17.3 n.u.; p=0.004). During REM sleep, we observed lower standard deviation of the R-R interval (SDNN) in HD subjects (3.4±2.2 vs 3.7±1.3 ms; p=0.015). Conclusion Our results showed that HD patients have higher heart rate than controls, during wake and NREM, but not during REM sleep. Among HRV variability parameters, the most relevant difference regarded the LF component, which reflects, at least partially, the ortho-sympathetic output. Our results confirm the involvement of autonomic nervous system in HD and demonstrate that it is evident during both wake and sleep.
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- 2021
16. Mechanical thrombectomy in patients with stroke due to large vessel occlusion in the anterior circulation and low baseline NIHSS score
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Alexandre, Andrea M, Valente, Iacopo, Frisullo, Giovanni, Morosetti, Roberta, Genovese, Danilo, Bartolo, Andrea, Gigli, Riccardo, Rollo, Claudia, Scarcia, Luca, Carosi, Francesca, Fortunato, Giusy, D'Argento, Francesco, Calabresi, Paolo, Della Marca, Giacomo, Pedicelli, Alessandro, Broccolini, Aldobrando, Calabresi, Paolo (ORCID:0000-0003-0326-5509), Della Marca, Giacomo (ORCID:0000-0001-6914-799X), Pedicelli, Alessandro (ORCID:0000-0002-2558-8838), Broccolini, Aldobrando (ORCID:0000-0001-8295-9271), Alexandre, Andrea M, Valente, Iacopo, Frisullo, Giovanni, Morosetti, Roberta, Genovese, Danilo, Bartolo, Andrea, Gigli, Riccardo, Rollo, Claudia, Scarcia, Luca, Carosi, Francesca, Fortunato, Giusy, D'Argento, Francesco, Calabresi, Paolo, Della Marca, Giacomo, Pedicelli, Alessandro, Broccolini, Aldobrando, Calabresi, Paolo (ORCID:0000-0003-0326-5509), Della Marca, Giacomo (ORCID:0000-0001-6914-799X), Pedicelli, Alessandro (ORCID:0000-0002-2558-8838), and Broccolini, Aldobrando (ORCID:0000-0001-8295-9271)
- Abstract
We sought to verify the benefit of mechanical thrombectomy in patients with acute ischemic stroke due to large vessel occlusion in the anterior circulation and low National Institute of Health stroke scale score at presentation. The prospective database of our stroke center was screened for patients with acute ischemic stroke due to large vessel occlusion and a baseline National Institute of Health stroke scale score <= 5 that had undergone mechanical thrombectomy. Outcome measures were the modified Rankin Scale (mRS) score at 90 days, brain bleeding events and death at 90 days. Out of 459 patients, 17 (12 females, mean age 70 +/- 14 years) with occlusion of M1 or M2 segment of middle cerebral artery and baseline National Institute of Health stroke scale score <= 5 underwent mechanical thrombectomy. Eight patients (47%) were treated within 6 hours from the onset, 5 (29%) were treated beyond 6 hours, and 4 (24%) were wakeup strokes. Effective mechanical thrombectomy was achieved in 16 patients (94%) and associated with excellent functional outcomes at 3 months (mRS 0-1) in 13 (76%). The asymptomatic brain-bleeding event was observed in one patient 4 days after effective mechanical thrombectomy concerning safety issues. One patient died 1 month after mechanical thrombectomy of a cause unrelated to stroke. Our findings favor a potential benefit of mechanical thrombectomy in patients with stroke due to large vessel occlusion and low National Institute of Health stroke scale score at presentation. These patients may also benefit from a prolonged time window for treatment.
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- 2021
17. An Italian Neurology Outpatient Clinic Facing SARS-CoV-2 Pandemic: Data From 2,167 Patients
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Piano, Carla, Di Stasio, Enrico, Primiano, Guido Alessandro, Janiri, Delfina, Luigetti, Marco, Frisullo, Giovanni, Vollono, Catello, Lucchini, Matteo, Brunetti, Valerio, Monforte, Mauro, Guglielmi, Valeria, Della Marca, Giacomo, Evoli Stampanoni-B, Amelia, Marra, Camillo, Mirabella, Massimiliano, Quaranta, Davide, Ricci, Enzo, Servidei, Serenella, Silvestri, Gabriella, Bellavia, Simone, Bortolani, Sara, Bove, Francesco, Di Iorio, Riccardo, Di Paolantonio, Andrea, Genovese, Danilo, Ialongo, Tamara, Lo Monaco, Maria Rita, Marotta, Jessica, Patanella, Agata Katia, Perna, Alessia, Petracca, Martina, Presicce, Giorgia, Riso, Vittorio, Rollo, Eleonora, Romano, Angela, Romozzi, Marina, Sancricca, Cristina, Scala, Irene, Spagni, Gregorio, Solito, Marcella, Tricoli, Luca, Zinzi, Paola, Calabresi, Paolo, Bentivoglio, Anna Rita, Di Stasio, Enrico (ORCID:0000-0003-1047-4261), Primiano, Guido, Luigetti, Marco (ORCID:0000-0001-7539-505X), Lucchini, Matteo (ORCID:0000-0002-0447-2297), Della Marca, Giacomo (ORCID:0000-0001-6914-799X), Evoli, Amelia (ORCID:0000-0003-0282-8787), Marra, Camillo (ORCID:0000-0003-3994-4044), Mirabella, Massimiliano (ORCID:0000-0002-7783-114X), Ricci, Enzo (ORCID:0000-0003-3092-3597), Servidei, Serenella (ORCID:0000-0001-8478-2799), Silvestri, Gabriella (ORCID:0000-0002-1950-1468), Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Piano, Carla, Di Stasio, Enrico, Primiano, Guido Alessandro, Janiri, Delfina, Luigetti, Marco, Frisullo, Giovanni, Vollono, Catello, Lucchini, Matteo, Brunetti, Valerio, Monforte, Mauro, Guglielmi, Valeria, Della Marca, Giacomo, Evoli Stampanoni-B, Amelia, Marra, Camillo, Mirabella, Massimiliano, Quaranta, Davide, Ricci, Enzo, Servidei, Serenella, Silvestri, Gabriella, Bellavia, Simone, Bortolani, Sara, Bove, Francesco, Di Iorio, Riccardo, Di Paolantonio, Andrea, Genovese, Danilo, Ialongo, Tamara, Lo Monaco, Maria Rita, Marotta, Jessica, Patanella, Agata Katia, Perna, Alessia, Petracca, Martina, Presicce, Giorgia, Riso, Vittorio, Rollo, Eleonora, Romano, Angela, Romozzi, Marina, Sancricca, Cristina, Scala, Irene, Spagni, Gregorio, Solito, Marcella, Tricoli, Luca, Zinzi, Paola, Calabresi, Paolo, Bentivoglio, Anna Rita, Di Stasio, Enrico (ORCID:0000-0003-1047-4261), Primiano, Guido, Luigetti, Marco (ORCID:0000-0001-7539-505X), Lucchini, Matteo (ORCID:0000-0002-0447-2297), Della Marca, Giacomo (ORCID:0000-0001-6914-799X), Evoli, Amelia (ORCID:0000-0003-0282-8787), Marra, Camillo (ORCID:0000-0003-3994-4044), Mirabella, Massimiliano (ORCID:0000-0002-7783-114X), Ricci, Enzo (ORCID:0000-0003-3092-3597), Servidei, Serenella (ORCID:0000-0001-8478-2799), Silvestri, Gabriella (ORCID:0000-0002-1950-1468), Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Calabresi, Paolo (ORCID:0000-0003-0326-5509), and Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X)
- Abstract
Objective:Neurological sequelae of SARS-CoV-2 infection have already been reported, but there is insufficient data about the impact of the pandemic on the management of the patients with chronic neurological diseases. We aim to analyze the effect of COVID-19 pandemic and social restriction rules on these fragile patients. Methods:Patients with chronic neurologic diseases routinely followed at the outpatient clinic of Gemelli University Hospital, Rome, were assessed for symptoms suggestive of SARS-CoV-2 infection in the pandemic period, consequences of social restrictions, and neurological disease features, concomitant medical conditions, current medical and disease-specific treatments. Data source: a dedicated telephone survey designed to encompass questions on COVID-19 symptoms and on pandemic effects in chronic neurologic conditions. Results:Overall, 2,167 individuals were analyzed: 63 patients reported contact with COVID-19 positive cases, 41 performed the swab, and 2 symptomatic patients tested positive for COVID-19 (0.09%). One hundred fifty-eight individuals (7%) needed urgent neurological care, deferred due to the pandemic; 641 patients (30%) suspended hospital treatments, physiotherapy or other support interventions; 405 individuals (19%) reported a subjective worsening of neurological symptoms. Conclusions:In our population, the presence of neurological chronic diseases did not increase the prevalence of COVID-19 infection. Nevertheless, the burden of neurological disorders has been worsened by the lockdown.
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- 2020
18. Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter Survey
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Piano, Carla, Bove, Francesco, Tufo, Tommaso, Imbimbo, Isabella, Genovese, Danilo, Stefani, Alessio, Marano, M., Peppe, A., Brusa, L., Cerroni, R., Motolese, F., Di Stasio, Enrico, Mazza, Marianna, Daniele, Antonio, Olivi, Alessandro, Calabresi, Paolo, Bentivoglio, Anna Rita, Piano C., Bove F., Tufo T., Imbimbo I., Genovese D., Stefani A., Di Stasio E. (ORCID:0000-0003-1047-4261), Mazza M., Daniele A. (ORCID:0000-0003-1641-5852), Olivi A. (ORCID:0000-0002-4489-7564), Calabresi P. (ORCID:0000-0003-0326-5509), Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Piano, Carla, Bove, Francesco, Tufo, Tommaso, Imbimbo, Isabella, Genovese, Danilo, Stefani, Alessio, Marano, M., Peppe, A., Brusa, L., Cerroni, R., Motolese, F., Di Stasio, Enrico, Mazza, Marianna, Daniele, Antonio, Olivi, Alessandro, Calabresi, Paolo, Bentivoglio, Anna Rita, Piano C., Bove F., Tufo T., Imbimbo I., Genovese D., Stefani A., Di Stasio E. (ORCID:0000-0003-1047-4261), Mazza M., Daniele A. (ORCID:0000-0003-1641-5852), Olivi A. (ORCID:0000-0002-4489-7564), Calabresi P. (ORCID:0000-0003-0326-5509), and Bentivoglio A. R. (ORCID:0000-0002-9663-095X)
- Abstract
Background: The containment measures taken by Italian government authorities during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic caused the interruption of neurological activities of outpatient clinics. Vulnerable patients, as Parkinson's disease (PD) and dystonic patients with deep brain stimulation (DBS), may have an increased risk of chronic stress related to social restriction measures and may show a potential worsening of motor and psychiatric symptoms. Methods: This cross-sectional multicenter study was carried out during the SARS-CoV-2 pandemic and was based on a structured survey administered during a telephone call. The questionnaire was designed to gather motor and/or psychiatric effects of the lockdown and coronavirus disease 2019 (COVID-19) epidemiologic information in PD and dystonic patients with a functioning DBS implant. Results: One hundred four patients were included in the study, 90 affected by PD and 14 by dystonia. Forty-nine patients reported a subjective perception of worsening of global neurological symptoms (motor and/or psychiatric) related to the containment measures. In the multivariate analysis, having problems with the DBS device was the only independent predictor of motor worsening [odds ratio (OR) = 3.10 (1.22–7.91), p = 0.018]. Independent predictors of psychiatric worsening were instrumental activities of daily living (IADL) score [OR = 0.78 (0.64–0.95), p = 0.012] and problems with DBS [OR = 5.69 (1.95–16.62), p = 0.001]. Only one patient underwent nasopharyngeal swabs, both negative, and no patient received a diagnosis of COVID-19. Conclusions: Lockdown restriction measures were associated with subjective worsening of motor and psychiatric symptoms in PD and dystonic patients treated with DBS, and they may have exacerbated the burden of neurological disease and increased the chronic stress related to the DBS management.
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- 2020
19. An Italian Neurology Outpatient Clinic Facing SARS-CoV-2 Pandemic: Data From 2,167 Patients
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Piano, Carla, primary, Di Stasio, Enrico, additional, Primiano, Guido, additional, Janiri, Delfina, additional, Luigetti, Marco, additional, Frisullo, Giovanni, additional, Vollono, Catello, additional, Lucchini, Matteo, additional, Brunetti, Valerio, additional, Monforte, Mauro, additional, Guglielmi, Valeria, additional, Della Marca, Giacomo, additional, Evoli, Amelia, additional, Marra, Camillo, additional, Mirabella, Massimiliano, additional, Quaranta, Davide, additional, Ricci, Enzo, additional, Servidei, Serenella, additional, Silvestri, Gabriella, additional, Bellavia, Simone, additional, Bortolani, Sara, additional, Bove, Francesco, additional, Di Iorio, Riccardo, additional, Di Paolantonio, Andrea, additional, Genovese, Danilo, additional, Ialongo, Tamara, additional, Lo Monaco, Maria Rita, additional, Marotta, Jessica, additional, Patanella, Agata Katia, additional, Perna, Alessia, additional, Petracca, Martina, additional, Presicce, Giorgia, additional, Riso, Vittorio, additional, Rollo, Eleonora, additional, Romano, Angela, additional, Romozzi, Marina, additional, Sancricca, Cristina, additional, Scala, Irene, additional, Spagni, Gregorio, additional, Solito, Marcella, additional, Tricoli, Luca, additional, Zinzi, Paola, additional, Calabresi, Paolo, additional, and Bentivoglio, Anna Rita, additional
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- 2020
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20. Mechanical thrombectomy in patients with stroke due to large vessel occlusion in the anterior circulation and low baseline NIHSS score.
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Alexandre, Andrea M., Valente, Iacopo, Frisullo, Giovanni, Morosetti, Roberta, Genovese, Danilo, Bartolo, Andrea, Gigli, Riccardo, Rollo, Claudia, Scarcia, Luca, Carosi, Francesca, Fortunato, Giusy, D'Argento, Francesco, Calabresi, Paolo, Della Marca, Giacomo, Pedicelli, Alessandro, and Broccolini, Aldobrando
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THROMBECTOMY ,STROKE patients ,TREATMENT effectiveness ,CEREBRAL arteries ,PATIENT safety - Abstract
We sought to verify the benefit of mechanical thrombectomy in patients with acute ischemic stroke due to large vessel occlusion in the anterior circulation and low National Institute of Health stroke scale score at presentation. The prospective database of our stroke center was screened for patients with acute ischemic stroke due to large vessel occlusion and a baseline National Institute of Health stroke scale score=5 that had undergone mechanical thrombectomy. Outcome measures were the modified Rankin Scale (mRS) score at 90 days, brain bleeding events and death at 90 days. Out of 459 patients, 17 (12 females, mean age 70 ± 14 years) with occlusion of M1 or M2 segment of middle cerebral artery and baseline National Institute of Health stroke scale score =5 underwent mechanical thrombectomy. Eight patients (47%) were treated within 6 hours from the onset, 5 (29%) were treated beyond 6 hours, and 4 (24%) were wakeup strokes. Effective mechanical thrombectomy was achieved in 16 patients (94%) and associated with excellent functional outcomes at 3 months (mRS 0-1) in 13 (76%). The asymptomatic brain-bleeding event was observed in one patient 4 days after effective mechanical thrombectomy concerning safety issues. One patient died 1 month after mechanical thrombectomy of a cause unrelated to stroke. Our findings favor a potential benefit of mechanical thrombectomy in patients with stroke due to large vessel occlusion and low National Institute of Health stroke scale score at presentation. These patients may also benefit from a prolonged time window for treatment. [ABSTRACT FROM AUTHOR]
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- 2021
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21. Prevalence of Impulsive-Compulsive Symptoms in Elderly Parkinson’s Disease Patients
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Monaco, Maria Rita Lo, primary, Petracca, Martina, additional, Weintraub, Daniel, additional, Fusco, Domenico, additional, Liperoti, Rosa, additional, Zuccalà, Giuseppe, additional, Carpia, Domenico La, additional, Vetrano, Davide Liborio, additional, Genovese, Danilo, additional, Pisciotta, Maria Stella, additional, Brandi, Vincenzo, additional, Padua, Luca, additional, Imbimbo, Isabella, additional, Ricciardi, Diego, additional, Bernabei, Roberto, additional, Silveri, Maria Caterina, additional, Laudisio, Alice, additional, and Bentivoglio, Anna Rita, additional
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- 2018
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22. Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter Survey.
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Piano C, Bove F, Tufo T, Imbimbo I, Genovese D, Stefani A, Marano M, Peppe A, Brusa L, Cerroni R, Motolese F, Di Stasio E, Mazza M, Daniele A, Olivi A, Calabresi P, and Bentivoglio AR
- Abstract
Background: The containment measures taken by Italian government authorities during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic caused the interruption of neurological activities of outpatient clinics. Vulnerable patients, as Parkinson's disease (PD) and dystonic patients with deep brain stimulation (DBS), may have an increased risk of chronic stress related to social restriction measures and may show a potential worsening of motor and psychiatric symptoms. Methods: This cross-sectional multicenter study was carried out during the SARS-CoV-2 pandemic and was based on a structured survey administered during a telephone call. The questionnaire was designed to gather motor and/or psychiatric effects of the lockdown and coronavirus disease 2019 (COVID-19) epidemiologic information in PD and dystonic patients with a functioning DBS implant. Results: One hundred four patients were included in the study, 90 affected by PD and 14 by dystonia. Forty-nine patients reported a subjective perception of worsening of global neurological symptoms (motor and/or psychiatric) related to the containment measures. In the multivariate analysis, having problems with the DBS device was the only independent predictor of motor worsening [odds ratio (OR) = 3.10 (1.22-7.91), p = 0.018]. Independent predictors of psychiatric worsening were instrumental activities of daily living (IADL) score [OR = 0.78 (0.64-0.95), p = 0.012] and problems with DBS [OR = 5.69 (1.95-16.62), p = 0.001]. Only one patient underwent nasopharyngeal swabs, both negative, and no patient received a diagnosis of COVID-19. Conclusions: Lockdown restriction measures were associated with subjective worsening of motor and psychiatric symptoms in PD and dystonic patients treated with DBS, and they may have exacerbated the burden of neurological disease and increased the chronic stress related to the DBS management., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2020 Piano, Bove, Tufo, Imbimbo, Genovese, Stefani, Marano, Peppe, Brusa, Cerroni, Motolese, Di Stasio, Mazza, Daniele, Olivi, Calabresi, Bentivoglio and Lazio DBS Study Group.)
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- 2020
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23. Prevalence of Impulsive-Compulsive Symptoms in Elderly Parkinson's Disease Patients: A Case-Control Study.
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Lo Monaco MR, Petracca M, Weintraub D, Fusco D, Liperoti R, Zuccalà G, La Carpia D, Vetrano DL, Genovese D, Pisciotta MS, Brandi V, Padua L, Imbimbo I, Ricciardi D, Bernabei R, Silveri MC, Laudisio A, and Bentivoglio AR
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- Aged, Aged, 80 and over, Case-Control Studies, Compulsive Behavior physiopathology, Consumer Behavior, Female, Humans, Male, Prevalence, Sexual Behavior physiology, Behavioral Symptoms diagnosis, Behavioral Symptoms epidemiology, Behavioral Symptoms etiology, Disruptive, Impulse Control, and Conduct Disorders diagnosis, Disruptive, Impulse Control, and Conduct Disorders epidemiology, Disruptive, Impulse Control, and Conduct Disorders etiology, Impulsive Behavior physiology, Parkinson Disease complications, Parkinson Disease diagnosis, Parkinson Disease epidemiology
- Abstract
Background: Impulse-control disorders (ICDs) are frequently described in patients with Parkinson's disease (PD), particularly among those treated with dopaminergic medications, but data on the prevalence of ICDs in elderly populations are lacking., Objective: The aim of this study was to estimate the prevalence of ICDs by using an Italian validation of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease (QUIP) and to identify associated sociodemographic and clinical factors in a sample of elderly PD patients and in a control group of similarly aged healthy volunteers., Methods: Using the United Kingdom Parkinson's Disease Society Brain Bank diagnostic criteria, we included 115 consecutive PD and 105 healthy controls. They were recruited from June 2014 to December 2015. All participants completed the self-administered QUIP-Anytime for assessment of ICDs occurring any time during the course of PD., Results: Mean ± SD age was 75.7 ± 7.0 years in the PD patients and 76.1 ± 7.0 years in the control group. The mean disease duration was 6.8 years (range, 1-26 years). Among the PD patients, 44.7% (n = 51) had at least 1 ICD or related disorder compared to 25.2% (n = 26) in the control group (between-group difference: P = .003). Hypersexuality and compulsive shopping were significantly more common in the PD group than in the control group (P < .05). The prevalence of other compulsive behaviors was 42.5% in the PD group and 38.9% in the control group (P = NS). The Italian version of the QUIP-Anytime showed high test-retest reliability (κ > 0.70 for all items)., Conclusions: Our data confirm a high prevalence of ICD symptoms in elderly PD patients, approximately twice that seen in the general population., (© Copyright 2018 Physicians Postgraduate Press, Inc.)
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- 2018
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