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Your search keyword '"Genital diseases, Male -- Risk factors"' showing total 20 results
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20 results on '"Genital diseases, Male -- Risk factors"'

1. New Nanoparticles Study Results Reported from National Center for Scientific Research (CNRS) (Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review)

Subjects
Nanomedicine -- Materials -- Complications and side effects, Nanoparticles -- Physiological aspects -- Health aspects, Silver -- Physiological aspects -- Health aspects, Genital diseases, Male -- Risk factors, Health
Abstract

2023 JAN 28 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on nanoparticles. According to news originating from the [...]

Published
2023

2. Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments

Author

Arzuaga, Xabier, Smith, Martyn T., Gibbons, Catherine F., Skakkeboek, Niels E., Yost, Erin E., Beverly, Brandiese E.J., Hotchkiss, Andrew K., Hauser, Russ, Pagani, Rodrigo L., Schrader, Steven M., Zeise, Lauren, and Prins, Gail S.

Subjects
Xenobiotics -- Identification and classification -- Health aspects, Teratogenic agents -- Identification and classification, Genital diseases, Male -- Risk factors, Environmental issues, Health
Abstract

Background: Assessing chemicals for their potential to cause male reproductive toxicity involves the evaluation of evidence obtained from experimental, epidemiological, and mechanistic studies. Although mechanistic evidence plays an important role in hazard identification and evidence integration, the process of identifying, screening and analyzing mechanistic studies and outcomes is a challenging exercise due to the diversity of research models and methods and the variety of known and proposed pathways for chemical-induced toxicity. Ten key characteristics of carcinogens provide a valuable tool for organizing and assessing chemical-specific data by potential mechanisms for cancer-causing agents. However, such an approach has not yet been developed for noncancer adverse outcomes. OBJECTIVES: The objective in this study was to identify a set of key characteristics that are frequently exhibited by exogenous agents that cause male reproductive toxicity and that could be applied for identifying, organizing, and summarizing mechanistic evidence related to this outcome. DISCUSSION: The identification of eight key characteristics of male reproductive toxicants was based on a survey of known male reproductive toxicants and established mechanisms and pathways of toxicity. The eight key characteristics can provide a basis for the systematic, transparent, and objective organization of mechanistic evidence relevant to chemical-induced effects on the male reproductive system. https://doi.org/10.1289/EHP5045, Introduction Exogenous Chemicals and Altered Male Reproductive Health There has been a decline in sperm counts (Levine et al. 2017) and a simultaneous rise in the incidence of testicular cancer [...]

Published
2019
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3. Synergistic disruption of external male sex organ development by a mixture of four antiandrogens

Author

Christiansen, Sofie, Scholze, Martin, Dalgaard, Majken, Vinggaard, Anne Marie, Axelstad, Marta, Kortenkamp, Andreas, and Hass, Ulla

Subjects
Antiandrogens -- Health aspects, Antiandrogens -- Research, Genital diseases, Male -- Risk factors, Genital diseases, Male -- Research, Reproductive organs, Male -- Physiological aspects, Reproductive organs, Male -- Research
Abstract

BACKGROUND: By disrupting the action of androgens during gestation, certain chemicals present in food, consumer products, and the environment can induce irreversible demasculinization and malformations of sex organs among male [...]

Published
2009

4. Phthalates impair germ cell development in the human fetal testis in vitro without change in testosterone production

Author

Lambrot, Romain, Muczynski, Vincent, Lecureuil, Charlotte, Angenard, Gaelle, Coffigny, Herve, Pairault, Catherine, Moison, Dephine, Frydman, Rene, Habert, Rene, and Rouiller-Fabre, Virginie

Subjects
Phthalates -- Health aspects, Phthalates -- Research, Genital diseases, Male -- Research, Genital diseases, Male -- Environmental aspects, Genital diseases, Male -- Risk factors, Testis -- Research, Testosterone -- Research, Germ cells -- Research
Abstract

BACKGROUND: Several studies have described an increasing frequency of male reproductive disorders, which may have a common origin in fetal life and which are hypothesized to be caused by endocrine [...]

Published
2009

5. Reproductive outcomes in male childhood cancer survivors: a linked-cancer-birth registry analysis

Author

Chow, Eric J., Kamineni, Aruna, Daling, Janet R., Fraser, Alison, Wiggins, Charles L., Mineau, Geraldine P., Hamre, Merlin R., Severson, Richard K., Drews-Botsch, Carolyn, and Mueller, Beth A.

Subjects
Cancer survivors -- Physiological aspects, Cancer survivors -- Health aspects, Cancer survivors -- Research, Genital diseases, Male -- Risk factors, Genital diseases, Male -- Demographic aspects, Genital diseases, Male -- Research, Cancer in children -- Patient outcomes, Cancer in children -- Research, Cancer -- Care and treatment, Cancer -- Patient outcomes, Cancer -- Demographic aspects, Cancer -- Research, Health
Published
2009

9. Diethylstilbestrol revisited: a review of the long-term health effects

Author

Giusti, Ruthann M., Iwamoto, Kumiko, and Hatch, Elizabeth E.

Subjects
Diethylstilbestrol -- Health aspects, Genital diseases, Female -- Risk factors, Genital diseases, Male -- Risk factors, Health
Abstract

* Purpose: To review the literature on the long-term health effects of exposure to diethylstilbestrol (DES) among women prescribed DES during pregnancy (DES mothers), among their children exposed in utero to the drug (DES sons and daughters) and among the progeny of these exposed sons and daughters (DES grandchildren). * Data Sources: English-language articles were identified through MEDLINE and CANCERLIT searches and through review of the bibliographies of identified articles. * Study Selection: All human studies relevant to long-term health effects of exposure to DES were reviewed. * Data Extraction: Descriptive data on existing DES cohorts were extracted from early publications. Risk estimates for health effects were extracted from published reports. * Data Synthesis: An estimated 5 to 10 million Americans received DES during pregnancy or were exposed to the drug in utero. Exposure to DES has been associated with an increased risk for breast cancer in DES Mothers (relative risk, * Conclusions: Further research is needed to define long-term health effects related to DES exposure. Such research would provide a basis for counseling persons exposed to DES and would further understanding of environmental and pharmacologic compounds similar to DES., Studies document serious long-term adverse effects in women who took diethylstilbestrol (DES) during pregnancy and in their daughters and sons. Women who took DES have about twice the risk of breast cancer compared with unexposed women. Women exposed to DES in the womb have a risk of between 1 in 1,000 to 1 in 10,000 between birth and age 34 for cervico-vaginal clear-cell adenoma, an extremely rare cancer. Abnormal cervical and vaginal cells are frequently observed, but the connection with cancer is unknown. One study found 3.6 times the risk of ovarian cancer. DES daughters often have developmental abnormalities of the reproductive tract, and they are more likely to be infertile and to have ectopic pregnancies, miscarriages, and preterm births. One study showed an increased lifetime risk for autoimmune disease. DES sons may have an increased risk of testicular cancer and urogenital abnormalities.

Published
1995

10. Windows of opportunity: a holistic approach to men's health

Author

Holden, Carol A., Allan, Carolyn A., and McLachlan, Robert I.

Subjects
Genital diseases, Male -- Risk factors, Type 2 diabetes -- Risk factors, Heart diseases -- Risk factors, Men -- Health aspects, Men -- Research, Health promotion, Health
Abstract

Evidence has ensured the associations between male reproductive health disorders and chronic diseases such as coronary heart disease and type 2 diabetes. MenEs health research is required in Australia in order to guide policy, innovative health promotion and clinical practice.

Published
2010

11. Genital Ulcers: Physical Clues Are No Substitute for Lab Tests

Subjects
Genital diseases, Male -- Risk factors, Genital diseases, Male -- Diagnosis, Genital diseases, Male -- Research, Sexually transmitted diseases -- Complications and side effects, Sexually transmitted diseases -- Research, Health
Abstract

Genital Ulcers: Physical Clues Are No Substitute for Lab Tests Source: DiCarlo RP, Martin DH. Clin Infect Dis 1997;25:292-298. Dicarlo and martin from new Orleans investigated the sensitivity of key [...]

Published
1997

12. Painkillers

Subjects
Analgesics -- Dosage and administration -- Complications and side effects, Pregnant women -- Drug use, Genital diseases, Male -- Risk factors, Biological sciences, Health
Abstract

Nov 8 Heavy usage of painkillers during pregnancy might lead to a host of male reproductive disorders in humans. A study of more than 2,500 infant boys in Denmark and [...]

Published
2010

13. The yin and yang of exposure: chemical combinations may explain feminization of wild fish

Author

Barrett, Julia R.

Subjects
Endocrine disruptors -- Health aspects, Fish populations -- Physiological aspects, Fish populations -- Environmental aspects, Fish populations -- Research, Genital diseases, Male -- Risk factors, Genital diseases, Male -- Research, Statistical models -- Usage, Feminization -- Research, Feminization -- Environmental aspects
Abstract

More than 100,000 substances occur in wastewater effluent, including an array of endocrine disruptors such as human and veterinary pharmaceuticals, natural and synthetic hormones, detergents, and industrial chemicals. Studies have [...]

Published
2009

14. Developmental picture window

Author

Barrett, Julia R.

Subjects
Endocrine disruptors -- Analysis, Endocrine disruptors -- Health aspects, Genital diseases, Male -- Risk factors, Genital diseases, Female -- Risk factors
Abstract

The concept of endocrine disruption emerged in the early 1990s with the observation that natural and industrial compounds were interfering with sex hormone signaling, thereby adversely affecting male and female [...]

Published
2009

15. Flour mill fathers have fewer sons

Author

Dooley, Erin E.

Subjects
Genital diseases, Male -- Risk factors, Genital diseases, Male -- Analysis, Pesticides -- Complications and side effects, Pesticides -- Environmental aspects, Pesticides -- Analysis, Workers -- Health aspects
Abstract

A body of research has shown that exposures to a number of chemicals can affect men's reproductive health as well the survival of male fetuses. Now a study in the [...]

Published
2008

17. Environmental Chemicals May Affect Male Reproduction; European study finds more evidence in areas where more men have problems

Subjects
Breast milk -- Health aspects, Breast milk -- Research, Endocrine disruptors -- Health aspects, Endocrine disruptors -- Research, Genital diseases, Male -- Risk factors, Genital diseases, Male -- Research
Abstract

THURSDAY, Sept. 24 (HealthDay News) -- High levels of persistent environmental chemicals are found in the breast milk of women in countries with high rates of male reproductive problems, say [...]

Published
2009

18. Agencies review plastic bottles

Author

Howell, Elizabeth

Subjects
Bisphenol-A -- Complications and side effects, Genital diseases, Female -- Risk factors, Genital diseases, Male -- Risk factors
Abstract

Health Canada is conducting a review of scientific literature to determine whether it should revise its threshold for the use of the chemical bisphenol A in food containers, particularly tin [...]

Published
2008

19. Common chemicals linked to male reproductive disorders

Author

Buckley, Liz

Subjects
Hazardous substances -- Health aspects, Genital diseases, Male -- Risk factors, Business, Chemicals, plastics and rubber industries, Environmental services industry, Food and beverage industries, Risk factors, Health aspects
Abstract

Exposure to various chemicals may be linked to adverse reproductive effects in males, according to a Colorado State University professor. 'It's been a difficult task to trace the impact of [...]

Published
2008

20. Association of CD4 Cell Depletion and Elevated Blood and Seminal Plasma Human Immunodeficiency Virus Type 1 (HIV-1) RNA Concentrations with Genital Ulcer Disease in HIV-1 Infected Men in Malawi.Journal of Infectious Diseases, January 1998;177(1):224-227

Subjects
Genital diseases, Male -- Risk factors, HIV infection -- Complications, Malawi -- Health aspects
Abstract

According to the authors' abstract of an article published in Journal of Infectious Diseases, "CD4 cell counts and blood plasma and seminal plasma human immunodeficiency virus type 1 (HIV-1) concentrations [...]

Published
1998

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