11 results on '"Geni F"'
Search Results
2. Sitagliptin treatment at the time of hospitalization was associated with reduced mortality in patients with type 2 diabetes and covid-19: A multicenter case-control retrospective observational study
- Author
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Solerte, S, D'Addio, F, Trevisan, R, Lovati, E, Rossi, A, Pastore, I, Acqua, M, Ippolito, E, Scaranna, C, Bellante, R, Galliani, S, Dodesini, A, Lepore, G, Geni, F, Fiorina, R, Catena, E, Corsico, A, Colombo, R, Mirani, M, Riva De, C, Oleandri, S, Abdi, R, Bonventre, J, Rusconi, S, Folli, F, Sabatino, A, Zuccotti, G, Galli, M, Fiorina, P, Solerte S. B., D'Addio F., Trevisan R., Lovati E., Rossi A., Pastore I., Acqua M. D., Ippolito E., Scaranna C., Bellante R., Galliani S., Dodesini A. R., Lepore G., Geni F., Fiorina R. M., Catena E., Corsico A., Colombo R., Mirani M., Riva De C., Oleandri S. E., Abdi R., Bonventre J. V., Rusconi S., Folli F., Sabatino A. D., Zuccotti G., Galli M., Fiorina P., Solerte, S, D'Addio, F, Trevisan, R, Lovati, E, Rossi, A, Pastore, I, Acqua, M, Ippolito, E, Scaranna, C, Bellante, R, Galliani, S, Dodesini, A, Lepore, G, Geni, F, Fiorina, R, Catena, E, Corsico, A, Colombo, R, Mirani, M, Riva De, C, Oleandri, S, Abdi, R, Bonventre, J, Rusconi, S, Folli, F, Sabatino, A, Zuccotti, G, Galli, M, Fiorina, P, Solerte S. B., D'Addio F., Trevisan R., Lovati E., Rossi A., Pastore I., Acqua M. D., Ippolito E., Scaranna C., Bellante R., Galliani S., Dodesini A. R., Lepore G., Geni F., Fiorina R. M., Catena E., Corsico A., Colombo R., Mirani M., Riva De C., Oleandri S. E., Abdi R., Bonventre J. V., Rusconi S., Folli F., Sabatino A. D., Zuccotti G., Galli M., and Fiorina P.
- Abstract
OBJECTIVE Poor outcomes have been reported in patients with type 2 diabetes and coronavirus disease 2019 (COVID-19); thus, it is mandatory to explore novel therapeutic approaches for this population. RESEARCH DESIGN AND METHODS In a multicenter, case-control, retrospective, observational study, sitagliptin, an oral and highly selective dipeptidyl peptidase 4 inhibitor, was added to standard of care (e.g., insulin administration) at the time of hospitalization in patients with type 2 diabetes who were hospitalized with COVID-19. Every center also recruited at a 1:1 ratio untreated control subjects matched for age and sex. All patients had pneumonia and exhibited oxygen saturation <95% when breathing ambient air or when receiving oxygen support. The primary end points were discharge from the hospital/death and improvement of clinical outcomes, defined as an increase in at least two points on a seven-category modified ordinal scale. Data were collected retrospectively from patients receiving sitagliptin from 1 March through 30 April 2020. RESULTS Of the 338 consecutive patients with type 2 diabetes and COVID-19 admitted in Northern Italy hospitals included in this study, 169 were on sitagliptin, while 169 were on standard of care. Treatment with sitagliptin at the time of hospitalization was associated with reduced mortality (18% vs. 37% of deceased patients; hazard ratio 0.44 [95% CI 0.29–0.66]; P = 0.0001), with an improvement in clinical outcomes (60% vs. 38% of improved patients; P = 0.0001) and with a greater number of hospital discharges (120 vs. 89 of discharged patients; P = 0.0008) compared with patients receiving standard of care, respectively. CONCLUSIONS In this multicenter, case-control, retrospective, observational study of patients with type 2 diabetes admitted to the hospital for COVID-19, sitagliptin treatment at the time of hospitalization was associated with reduced mortality and improved clinical outcomes as compared with standard-of-care treatme
- Published
- 2020
3. Pediatric Cervical Spine Injury: A Three-Year Experience
- Author
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Givens, Timothy G., Polley, Kevin A., Smith, Geni F., and Hardin, William D.
- Published
- 1996
4. Comparison of recidivism rates for a teenage trauma prevention program after the addition of high-fidelity patient simulation
- Author
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Samuel Strachan, Walter T Parker, Dawn Taylor Peterson, Amber Q. Youngblood, Nancy M. Tofil, Geni F. Smith, Marjorie Lee White, Peter A. Sloane, J. Lynn Zinkan, and Ashley Dodd
- Subjects
Male ,Automobile Driving ,Adolescent ,Accident prevention ,Applied psychology ,Risk Assessment ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,High fidelity ,Accident Prevention ,Juvenile delinquency ,Humans ,030212 general & internal medicine ,Young adult ,Patient simulation ,Recidivism ,Public Health, Environmental and Occupational Health ,Accidents, Traffic ,030208 emergency & critical care medicine ,Patient Simulation ,High fidelity simulation ,Juvenile Delinquency ,Female ,Risk assessment ,Psychology ,Safety Research ,Social psychology - Abstract
We evaluated the benefits of adding high-fidelity simulation to a teenage trauma prevention program to decrease recidivism rates and encourage teens to discuss actionable steps toward safe driving.A simulated pediatric trauma scenario was integrated into an established trauma prevention program. Participants were recruited because they were court-ordered to attend this program after misdemeanor convictions for moving violations. The teenage participants viewed this simulation from the emergency medical services (EMS) handoff to complete trauma care. Participants completed a postsimulation knowledge assessment and care evaluation, which included narrative data about the experience. Qualitative analysis of color-coded responses identified common themes and experiences in participants' answers. Court records were reviewed 6 years after course completion to determine short- and long-term recidivism rates, which were then compared to our program's historical rate.One hundred twenty-four students aged 16-20 years participated over a 2-year study period. Narrative responses included general reflection, impressions, and thoughts about what they might change as a result of the course. Participants reported that they would decrease speed (30%), wear seat belts (15%), decrease cell phone use (11%), and increase caution (28%). The recidivism rate was 55% within 6 years. At 6 months it was 8.4%, at 1 year it was 20%, and it increased approximately 5-8% per year after the first year. Compared with our programs, for historical 6-month and 2-year recidivism rates, no significant difference was seen with or without simulation.Adding simulation is well received by participants and leads to positive reflections regarding changes in risk-taking behaviors but resulted in no changes to the high recidivism rates This may be due to the often ineffectiveness of fear appeals.
- Published
- 2017
5. Pediatric firearm injuries: a 10-year single-center experience of 194 patients
- Author
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Richard Keijzer, Geni F. Smith, Oliver J. Muensterer, and Carolin Senger
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medicine.medical_specialty ,Adolescent ,Black People ,Poison control ,Violence ,Suicide prevention ,White People ,Occupational safety and health ,Young Adult ,Injury prevention ,Cluster Analysis ,Humans ,Medicine ,Registries ,Child ,Retrospective Studies ,business.industry ,Incidence ,Incidence (epidemiology) ,Mortality rate ,Trauma center ,Infant ,Retrospective cohort study ,General Medicine ,medicine.disease ,Suicide ,Accidents ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Emergency medicine ,Alabama ,Wounds, Gunshot ,Surgery ,Seasons ,Medical emergency ,business - Abstract
BACKGROUND: The objective was to investigate the relationship of high gun ownership and gun death rate on children and determine predictors influencing the incidence and outcome of pediatric firearm injuries in a major pediatric level 1 trauma center. METHODS: We performed a retrospective review of our trauma registry to identify hospital admissions between April 1999 and March 2010. We extracted demographic and geographic data, seasonal variation, injury type, firearm type, and outcome. RESULTS: We identified 194 firearm injuries. The incidence did not change during the past decade. Most occurred during the second half of the year (61.4%). Mean age was 12.2 ± 4.6 years (range, 0.4-19.2 years). Unintentional shootings accounted for 100 injuries followed by assaults (n = 55) and innocent bystanders (n = 39). African American children were most often injured because of a violent cause (60.3%), whereas white children were shot unintentionally (80.1%). Powder-propelled firearms caused 82.5% of injuries. Overall, 17.5% of children required an operation, and 9.3% died. CONCLUSIONS: The overwhelming majority of children were injured after a gun went off unintentionally, whereas most African American children were shot violently. We identified certain seasonal and geographic clusters. These data can be used to target gun injury prevention programs. Language: en
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- 2011
- Full Text
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6. Use of laparoscopy in the management of pediatric abdominal trauma
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C. M. Harmon, Ahmed I. Marwan, Geni F. Smith, Oliver J. Muensterer, and Keith E. Georgeson
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Male ,medicine.medical_specialty ,Delayed Diagnosis ,Adolescent ,medicine.medical_treatment ,Wounds, Penetrating ,Abdominal Injuries ,Critical Care and Intensive Care Medicine ,Wounds, Nonpenetrating ,Blunt ,Injury Severity Score ,Laparotomy ,medicine ,Humans ,Laparoscopy ,Child ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,General surgery ,medicine.disease ,Surgery ,Endoscopy ,Early Diagnosis ,Treatment Outcome ,Abdominal trauma ,El Niño ,Child, Preschool ,Female ,business ,Penetrating trauma ,Pediatric trauma - Abstract
Background: Anecdotally, laparoscopy has been used for the diagnosis and therapy of pediatric abdominal trauma, but only few studies have been published. We performed a systematic analysis of our experience concerning indications, procedures, and outcomes using laparoscopy in pediatric abdominal trauma patients. Methods: Our trauma database was searched for patients who underwent laparoscopy after being admitted for abdominal trauma. Cases were grouped into diagnostic and therapeutic procedures. Success was defined as attaining the correct diagnosis or as the ability to repair the injury by laparoscopy. Results: Of 4,836 pediatric trauma admissions over a period of 12 years, 92 had open or laparoscopic abdominal explorations for blunt (n = 47) and penetrating (n = 35) injuries. In 21 patients, diagnostic laparoscopic procedures were performed, and 5 of these children also underwent a therapeutic laparoscopy. Nineteen patients were treated in the acute setting and two in a delayed fashion. Overall, 19 of 21 laparoscopies correctly diagnosed the injury, and all the 5 laparoscopic therapeutic procedures were successful. There was a significant difference in success rate of diagnostic laparoscopy between acute and delayed cases (p < 0.01). Retrospectively, laparotomy was avoided in 13 of 21 patients overall and in 10 of 10 patients with penetrating trauma (p = 0.02). Conclusions: Laparoscopy is useful in the management of the hemodynamically stable pediatric patient with abdominal trauma but may be less valuable in cases with delayed presentation. Many intraabdominal injuries are amenable to laparoscopic repair. In patients with penetrating trauma, laparoscopy avoided laparotomy is more likely than in those with blunt abdominal trauma. Laparoscopy is currently underutilized in the management of pediatric abdominal trauma.
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- 2010
7. Use of Laparoscopy in the Management of Pediatric Abdominal Trauma
- Author
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Marwan, Ahmed, primary, Harmon, Carrol M., additional, Georgeson, Keith E., additional, Smith, Geni F., additional, and Muensterer, Oliver J., additional
- Published
- 2010
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8. The first two years' experience with major trauma at a pediatric trauma center
- Author
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Keith E. Georgeson, Geni F. Smith, and Charles W. Breaux
- Subjects
Male ,medicine.medical_specialty ,Resuscitation ,Adolescent ,Poison control ,Traumatology ,Wounds, Penetrating ,Critical Care and Intensive Care Medicine ,Wounds, Nonpenetrating ,Trauma Centers ,Epidemiology ,medicine ,Prevalence ,Humans ,Child ,Coma ,business.industry ,Major trauma ,Incidence (epidemiology) ,Length of Stay ,medicine.disease ,Surgery ,Transportation of Patients ,Alabama ,Wounds and Injuries ,Female ,Seasons ,medicine.symptom ,business ,Burns ,Pediatric trauma - Abstract
We reviewed the records of 233 patients with major trauma admitted to The Children's Hospital of Alabama during the first 2 years of operation of its Pediatric Trauma Center. The male-to-female ratio was 1.7:1. The highest incidence of trauma occurred in the spring (88 patients, 38%) and the lowest in the winter (36 patients, 15%). Most children (184, 79%) were injured between noon and midnight. Blunt mechanisms of injury accounted for 206 patients (88%), penetrating for 17 (7%), and burns for ten (4%). The distribution of injuries by organ system was head/neurologic, 185 patients (79%); musculoskeletal, 83 (36%); thoracic, 57 (24%); abdominal, 29 (12%); major soft-tissue, 26 (11%), genitourinary, 11 (5%); and vascular, 11 (5%). Surgery was required at some point during the hospitalization in 89 patients (38%). Seventy-two patients (31%) experienced 115 complications. The mean length of time spent for resuscitation and stabilization in the trauma room was 49 min. The mean ICU stay was 3.2 days. Total length of hospitalization averaged 11.2 days. Twenty-six patients (11%) died. The Pediatric Trauma Score and the Pediatric Coma Score were found to be predictive of outcome. The organization and function of the trauma team is described, and public health concerns are discussed.
- Published
- 1990
9. EDUCAÇÃO EM DIREITOS HUMANOS E FORMAÇÃO POLICIAL MILITAR: UMA ANÁLISE INTERCULTURAL ENTRE HUMANIZAÇÃO E MILITARIZAÇÃO
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Geni Francinelle Alves
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Education (General) ,L7-991 ,Special aspects of education ,LC8-6691 - Abstract
O presente artigo tem como objetivo promover uma reflexão em torno da relação existente entre a educação voltada para os direitos humanos e a formação policial militar, tendo como principal enfoque a aplicação de uma educação intercultural, que possibilite a emancipação social através de uma formação cidadã. Para tanto, será examinado o Plano Nacional de Educação em Direitos Humanos, buscando-se compreender a interação entre suas diretrizes e a sua consolidação prática nos sistemas de Segurança Pública, com destaque ao locus Policial Militar, tendo como elemento diferenciador a cultura organizacional voltada para a militarização em contraposição à humanização de seus integrantes. Este estudo segue como referencial teórico, o autor Paulo Freire através das obras: Educação e Atualidade Brasileira e Ação Cultural para a Liberdade e outros escritos, utilizando-se como metodologia o materialismo histórico dialético para nortear a análise da temática proposta, buscando-se colaborar para uma compreensão teórico-crítica mais abrangente acerca do assunto, ainda pouco explorado.
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- 2016
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10. Sitagliptin Treatment at the Time of Hospitalization Was Associated With Reduced Mortality in Patients With Type 2 Diabetes and COVID-19: A Multicenter, Case-Control, Retrospective, Observational Study
- Author
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Marco Mirani, Riccardo Colombo, Ida Pastore, Rosalia Bellante, Francesca D'Addio, Angelo Corsico, Alessandro Roberto Dodesini, Cristiana Scaranna, Silvia Galliani, Sebastiano Bruno Solerte, Roberto Trevisan, Elisabetta Lovati, Giuseppe Lepore, Franco Folli, Emanuele Catena, Salvatore Endrio Oleandri, Marco Dell’Acqua, Antonio Rossi, Elio Ippolito, Francesca Geni, Antonio Di Sabatino, Carlo De Riva, Gian Vincenzo Zuccotti, Paolo Fiorina, Roberta Maria Fiorina, Reza Abdi, Massimo Galli, Joseph V. Bonventre, Stefano Rusconi, Solerte, S, D'Addio, F, Trevisan, R, Lovati, E, Rossi, A, Pastore, I, Acqua, M, Ippolito, E, Scaranna, C, Bellante, R, Galliani, S, Dodesini, A, Lepore, G, Geni, F, Fiorina, R, Catena, E, Corsico, A, Colombo, R, Mirani, M, Riva De, C, Oleandri, S, Abdi, R, Bonventre, J, Rusconi, S, Folli, F, Sabatino, A, Zuccotti, G, Galli, M, and Fiorina, P
- Subjects
medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Coronaviru ,Pneumonia, Viral ,Population ,030209 endocrinology & metabolism ,Type 2 diabetes ,Dipeptidyl peptidase-4 inhibitor ,Sitagliptin Phosphate ,03 medical and health sciences ,0302 clinical medicine ,Retrospective Studie ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,030212 general & internal medicine ,education ,Advanced and Specialized Nursing ,education.field_of_study ,Betacoronaviru ,Pandemic ,Emerging Therapies: Drugs and Regimens ,SARS-CoV-2 ,Coronavirus Infection ,business.industry ,Hazard ratio ,COVID-19 ,Retrospective cohort study ,medicine.disease ,Hospitalization ,Italy ,Diabetes Mellitus, Type 2 ,Sitagliptin ,business ,Human ,medicine.drug - Abstract
OBJECTIVE Poor outcomes have been reported in patients with type 2 diabetes and coronavirus disease 2019 (COVID-19); thus, it is mandatory to explore novel therapeutic approaches for this population. RESEARCH DESIGN AND METHODS In a multicenter, case-control, retrospective, observational study, sitagliptin, an oral and highly selective dipeptidyl peptidase 4 inhibitor, was added to standard of care (e.g., insulin administration) at the time of hospitalization in patients with type 2 diabetes who were hospitalized with COVID-19. Every center also recruited at a 1:1 ratio untreated control subjects matched for age and sex. All patients had pneumonia and exhibited oxygen saturation RESULTS Of the 338 consecutive patients with type 2 diabetes and COVID-19 admitted in Northern Italy hospitals included in this study, 169 were on sitagliptin, while 169 were on standard of care. Treatment with sitagliptin at the time of hospitalization was associated with reduced mortality (18% vs. 37% of deceased patients; hazard ratio 0.44 [95% CI 0.29–0.66]; P = 0.0001), with an improvement in clinical outcomes (60% vs. 38% of improved patients; P = 0.0001) and with a greater number of hospital discharges (120 vs. 89 of discharged patients; P = 0.0008) compared with patients receiving standard of care, respectively. CONCLUSIONS In this multicenter, case-control, retrospective, observational study of patients with type 2 diabetes admitted to the hospital for COVID-19, sitagliptin treatment at the time of hospitalization was associated with reduced mortality and improved clinical outcomes as compared with standard-of-care treatment. The effects of sitagliptin in patients with type 2 diabetes and COVID-19 should be confirmed in an ongoing randomized, placebo-controlled trial.
- Published
- 2020
11. Sitagliptin Treatment at the Time of Hospitalization Was Associated With Reduced Mortality in Patients With Type 2 Diabetes and COVID-19: A Multicenter, Case-Control, Retrospective, Observational Study.
- Author
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Solerte SB, D'Addio F, Trevisan R, Lovati E, Rossi A, Pastore I, Dell'Acqua M, Ippolito E, Scaranna C, Bellante R, Galliani S, Dodesini AR, Lepore G, Geni F, Fiorina RM, Catena E, Corsico A, Colombo R, Mirani M, De Riva C, Oleandri SE, Abdi R, Bonventre JV, Rusconi S, Folli F, Di Sabatino A, Zuccotti G, Galli M, and Fiorina P
- Subjects
- Betacoronavirus, COVID-19, Hospitalization, Humans, Italy, Retrospective Studies, SARS-CoV-2, Sitagliptin Phosphate therapeutic use, Coronavirus, Coronavirus Infections, Diabetes Mellitus, Type 2 drug therapy, Pandemics, Pneumonia, Viral
- Abstract
Objective: Poor outcomes have been reported in patients with type 2 diabetes and coronavirus disease 2019 (COVID-19); thus, it is mandatory to explore novel therapeutic approaches for this population., Research Design and Methods: In a multicenter, case-control, retrospective, observational study, sitagliptin, an oral and highly selective dipeptidyl peptidase 4 inhibitor, was added to standard of care (e.g., insulin administration) at the time of hospitalization in patients with type 2 diabetes who were hospitalized with COVID-19. Every center also recruited at a 1:1 ratio untreated control subjects matched for age and sex. All patients had pneumonia and exhibited oxygen saturation <95% when breathing ambient air or when receiving oxygen support. The primary end points were discharge from the hospital/death and improvement of clinical outcomes, defined as an increase in at least two points on a seven-category modified ordinal scale. Data were collected retrospectively from patients receiving sitagliptin from 1 March through 30 April 2020., Results: Of the 338 consecutive patients with type 2 diabetes and COVID-19 admitted in Northern Italy hospitals included in this study, 169 were on sitagliptin, while 169 were on standard of care. Treatment with sitagliptin at the time of hospitalization was associated with reduced mortality (18% vs. 37% of deceased patients; hazard ratio 0.44 [95% CI 0.29-0.66]; P = 0.0001), with an improvement in clinical outcomes (60% vs. 38% of improved patients; P = 0.0001) and with a greater number of hospital discharges (120 vs. 89 of discharged patients; P = 0.0008) compared with patients receiving standard of care, respectively., Conclusions: In this multicenter, case-control, retrospective, observational study of patients with type 2 diabetes admitted to the hospital for COVID-19, sitagliptin treatment at the time of hospitalization was associated with reduced mortality and improved clinical outcomes as compared with standard-of-care treatment. The effects of sitagliptin in patients with type 2 diabetes and COVID-19 should be confirmed in an ongoing randomized, placebo-controlled trial., (© 2020 by the American Diabetes Association.)
- Published
- 2020
- Full Text
- View/download PDF
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