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27. Surface-Pt-rich AgPtAu trimetallic nanotrough arrays for boosting alcohol electrooxidation.

Author

Li, Jing-Jing, Geng, Wen-Chao, Jiang, Ling, and Li, Yong-Jun

Subjects
*INTERFACIAL reactions, *CATALYSIS, *ALCOHOL as fuel, *ETHANOL, *FUEL cells, *METHANOL, *ALCOHOL
Abstract

To develop high-performance low-Pt electrocatalysts for direct alcohol fuel cells (DAFCs), we herein propose an interfacial engineering strategy, using interfacial Ag nanowire arrays as a sacrificing template and successfully fabricating a AgPtAu nanotrough array catalyst at water/air interfaces. By adjusting the conditions of interfacial reaction, composition-varied AgPtAu nanotrough arrays can be easily obtained. The formation of a trough-like morphology of AgPtAu can be attributed to the interface-confined Ag nanowire arrays reacting successively with PtCl62− and AuCl4− in the water phase. Optimized surface-Pt-rich Ag11Pt5Au84 nanotrough arrays exhibit ∼2270 and ∼2290 mA mgAu+Pt−1 in the mass activity towards methanol and ethanol electrooxidation, respectively, ∼3 times better than that of commercial Pt/C, and show improved tolerance towards CO-like carbonaceous intermediates. This work suggests that properly combining the positive catalytic effects of morphology and composition may be a possible avenue to tackle the issue of low-Pt electrocatalysts for DAFCs. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Additional file 1 of Coassembly of hypoxia-sensitive macrocyclic amphiphiles and extracellular vesicles for targeted kidney injury imaging and therapy

Author

Cheng, Yuan-Qiu, Yue, Yu-Xin, Cao, Hong-Mei, Geng, Wen-Chao, Wang, Lan-Xing, Hu, Xin-Yue, Li, Hua-Bin, Bian, Qiang, Kong, Xiang-Lei, Liu, Jian-Feng, Kong, De-Ling, Guo, Dong-Sheng, and Wang, Yue-Bing

Abstract

Additional file 1: Figure S1. Synthetic route of C5A. Figure S2. 1H NMR spectrum of 1 in DMSO-d6, 400 MHz, 25 ��C. Figure S3. (a) 1H NMR spectrum of C5A in DMSO-d6, 400 MHz, 25 ��C. (b) 13C NMR spectrum of C5A in DMSO-d6, 100 MHz, 25 ��C. Figure S4. Absorbance of C5A (10 ��M) at 400 nm as a function of time following addition of SDT (2 mM) in PBS buffer (10 mM), and the corresponding fitting curve according to quasi-first order reaction decay model. Figure S5. Mass spectrum of C5A (QFT-ESI). Figure S6. Zeta potential detection of C5A@EVs and Pc/C5A@EVs upon incubation with or without SDT in PBS buffer. (a) Zeta potential measure of C5A@EVs in the absence (blue) or presence of SDT (red) in PBS buffer (10 mM, pH = 7.4) at 25 ���. (b) Zeta potential measure of Pc/C5A@EVs in the absence (blue) or presence of SDT (red) in PBS buffer (10 mM, pH = 7.4) at 25 ���. Figure S7. Representative TEM images of Pc/C5A@EVs on day 1, 3 and 7. Scale bar, 100 nm. Figure S8. In vitro colocalization of Pc/C5A@EVs and EVs with LysoTracker Red in TECs by CLSM. Figure S9. CLSM images of Pc/C5A under hypoxic or normoxic condition. Figure S10. CLSM images of Pc@EVs under hypoxic or normoxic condition. Figure S11. Hemolysis rate of Pc/C5A and Pc/C5A@EVs after incubation with mouse erythrocytes. Figure S12. Body weight changes of the mice with different treatments (n = 5). Figure S13. In vivo imaging of kidney hypoxia via Pc/C5A@EVs and Pc/C5A. (a) Illustration of the imaging tracing strategy after intravenous injection of Pc/C5A@EVs or Pc/C5A in unilateral hypoxic renal injury mice. (b) In vivo fluorescence images of Pc/C5A@EVs and Pc/C5A in unilateral hypoxic renal injury mice. Figure S14. In vivo imaging of hypoxia-injured mice with intravenous injection of Pc, Pc@EVs or PKH26@EVs at different time intervals (n = 3). Figure S15. (a) Ex vivo images of major organs at the designed time points after Pc, Pc@EV or PKH26@EV administration. (b-d) Time-dependent fluorescence intensity changes in major organs at designated time intervals after sacrificing renal hypoxia-injured mice (n = 5). Figure S16. Representative CLSM images of kidney slices from the renal hypoxia-injured mice after administration of Pc/C5A@EVs or Pc/C5A for 24 h. Figure S17. (a) Representative H&E-staining images of kidney sections on day 1, 3 and 7 after injection. Massive necrosis in the proximal tubules with hyaline cast formation (asterisks) was observed, and administration of Pc/C5A@EVs largely prevented histopathologic alterations after hypoxic injury. Scale bar, 50 ��m. (b-c) Quantitative histological assessment of hyaline cast formation (b) and tubular necrosis (c) on day 3 postinjection. Figure S18. RT-qPCR analysis of the expression of apoptosis-related genes on day 7 postinjection. Figure S19. Representative Western blot showing Caspase 8 expression in kidney tissues with different treatments on day 7 postinjection. (a) Representative Western blot images of Caspase 8 in different groups. (b) Quantitative analysis of Western blot. Figure S20. Representative images of Masson trichrome staining in different groups (n = 8). Figure S21. Representative images of immunofluorescence staining of F4/80 (green) and Pc/C5A@EVs or Pc/C5A (red) in the kidney tissues in different groups. Figure S22. The raw data for Western blot in Fig. 2d. Figure S23. The raw data for Western blot in Fig. 6a. Figure S24. The raw data for Western blot in Fig. 6b. Figure S25. The raw data for Western blot in Fig. 6c. Figure S26. The raw data for Western blot in Fig. 7j. Figure S27. The raw data for Western blot in Fig. 8k-l. Table S1 Primers used in the RT-qPCR assay.

Published
2021
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34. Macrocyclic‐Amphiphile‐Based Self‐Assembled Nanoparticles for Ratiometric Delivery of Therapeutic Combinations to Tumors

Author

Zhang, Zhanzhan, primary, Yue, Yu‐Xin, additional, Xu, Lina, additional, Wang, Ying, additional, Geng, Wen‐Chao, additional, Li, Juan‐Juan, additional, Kong, Xiang‐lei, additional, Zhao, Xinzhi, additional, Zheng, Yadan, additional, Zhao, Yu, additional, Shi, Linqi, additional, Guo, Dong‐Sheng, additional, and Liu, Yang, additional

Published
2021
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35. Monitoring Methionine Decarboxylase by a Supramolecular Tandem Assay.

Author

Zheng, Zhe, Ren, Siying, Geng, Wen‐Chao, Cui, Xuexian, Wu, Bian, and Wang, Hong

Subjects
METHIONINE, ESSENTIAL amino acids, ACRIDINE derivatives, ACRIDINE orange
Abstract

Methionine is an essential amino acid involved in many physiological and pathological processes. Methionine starvation caused by methionine decarboxylase (MetDC) degradation becomes a promising strategy for cancer treatment. Multistep colorimetric method, the present approach to monitor the MetDC activity, possesses drawbacks of the complicated process, low accuracy, and poor anti‐interference due to indirect detection. Herein, we report a facile and easy‐to‐use supramolecular tandem assay (STA) with the cucurbit[7]uril and acridine orange reporter pair for the direct and real‐time monitoring of MetDC activity. This strategy not only provides a feasible method for enzymatic activity detection but also establishes the capability of inhibitor screening. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Sensitive fluorescence detection of saliva pepsin by a supramolecular tandem assay enables the diagnosis of gastroesophageal reflux disease.

Author

Zheng, Zhe, Geng, Wen-Chao, Li, Hua-Bin, and Guo, Dong-Sheng

Subjects
*GASTROESOPHAGEAL reflux, *PEPSIN, *SALIVA, *ARTIFICIAL saliva, *FLUORESCENCE, *POINT-of-care testing
Abstract

Gastroesophageal reflux disease (GERD) is a prevalent gastrointestinal disorder with substantial morbidity. However, the reliable, non-invasive, and specific diagnosis of GERD remains a challenge due to the lack of specific symptoms and imaging features. Herein, we report a supramolecular tandem assay through using a reporter pair of sulfonatocalix[4]arene and lucigenin for the sensitive and real-time detection of saliva pepsin, an ideal biomarker for GERD. Moreover, we achieve the detection of pepsin in commercial artificial saliva, demonstrating the potential of this supramolecular approach for point-of-care testing of GERD. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Supramolecular design based activatable magnetic resonance imaging.

Author

Geng, Wen‐Chao, Zheng, Zhe, and Guo, Dong‐Sheng

Abstract

Magnetic resonance imaging (MRI) has been widely used in clinical diagnosis. In recent years, activatable MRI probes responding to specific changes in their microenvironment have been developed. The signal of the MRI probe can be modulated based on supramolecular design, which can include properties such as self‐assembly and molecular recognition. In this review, we summarize the activatable MRI probes based on the design principles of supramolecular chemistry. We also discuss the current challenges and the future perspectives for how activatable MRI can achieve more extensive clinical applications for cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2021
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